CN104435207A - Traditional Chinese medicine granule for assistance on blood lipid reduction - Google Patents
Traditional Chinese medicine granule for assistance on blood lipid reduction Download PDFInfo
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- CN104435207A CN104435207A CN201410759033.4A CN201410759033A CN104435207A CN 104435207 A CN104435207 A CN 104435207A CN 201410759033 A CN201410759033 A CN 201410759033A CN 104435207 A CN104435207 A CN 104435207A
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- 150000002632 lipids Chemical class 0.000 title abstract description 9
- 230000009467 reduction Effects 0.000 title abstract description 3
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- AWUCVROLDVIAJX-UHFFFAOYSA-N glycerol 1-phosphate Chemical compound OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
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- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
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- 230000003442 weekly effect Effects 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/64—Orobanchaceae (Broom-rape family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a traditional Chinese medicine granule for assistance on blood lipid reduction. The traditional Chinese medicine granule is prepared from the following Chinese medicine raw materials in parts by weight: 2-5 parts of silkworm chrysalis compound amino acid powder, 6-20 parts of radix pseudostellariae, 10-15 parts of radix achyranthis bidentatae, 12-20 parts of honey-fried licorice root, 6-20 parts of mushroom, 8-16 parts of Chinese hawthorn leaves, 2-8 parts of herba cistanche, 8-12 parts of panax japonicas, 3-12 parts of hericium erinaceus, 6-9 parts of tortoise shell and 2-3 parts of polygonum multiflorum. According to the traditional Chinese medicine granule, traditional Chinese herbal medicines of China are perfectly matched with a basic substance amino acid for a human body, so that the blood lipid of the human body can be effectively lowered.
Description
Technical field
The present invention relates to Chinese medicine health-care technical field, especially relate to a kind of can the instant particles as Chinese medicine of auxiliary antilipemic.
Background technology
Research auxiliary function for lowering blood pressure food object is not be to reduce patients' blood merely, and emphasis is to improve hypertension symptom, promotes the recovery of the heart, brain, kidney, blood vessel pathological change.Modern medicine study proves, doctor trained in Western medicine depressor and traditional Chinese medical science depressor respectively have its pluses and minuses.Western medicine the unresolved pathological factor causing blood pressure to raise, the rising once drug withdrawal blood pressure will rebound very soon, makes patient take medicine all the life; Though the antihypertensive effect of Chinese medicine is not as Western medicine, by its adjustment to internal organs function, improve the pathological factor that causes blood pressure to raise and reach the effect of control blood pressure rising.And the traditional Chinese medical science thinks that Diet cures more than the doctors, the ideal chose of the hyperpietic especially of the medicine with medicine-food two-purpose.Research shows, antihypertensive function food functional component mainly contains flavone (rutin etc.), saponin, unsaturated fatty acid, crude polysaccharides, oligosaccharides, vitamin, potassium magnesium selenium and other trace elements.
At present, market has the health food of kind more than 60 " aided blood pressure-lowering " function, product mostly and the function such as auxiliary antilipemic, improving water flood, antioxidation, auxiliary hyperglycemic arrange in pairs or groups, most aided blood pressure-lowering material also has the function of blood fat reducing.Dosage form, be that the capsule of raw material, tea-drinking, extract electuary are the most common with Chinese herbal medicine.
Summary of the invention
For the problems referred to above that prior art exists, the applicant provides a kind of instant particles as Chinese medicine of auxiliary antilipemic.Advantage of the present invention is according to traditional Chinese herbal medicine with reducing blood pressure and blood fat, coordinates the aminoacid that can regulate and control blood fat and blood pressure to reach the two effect of falling of blood pressure blood fat.
Technical scheme of the present invention is as follows:
An instant particles as Chinese medicine for auxiliary antilipemic, is made up of the herbal raw material of following parts by weight: 2 ~ 5 parts, silkworm compound amino acid powder, Radix Pseudostellariae 6 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts, Radix Glycyrrhizae Preparata 12 ~ 20 parts, 6 ~ 20 parts, Lentinus Edodes, Folium Crataegi 8 ~ 16 parts, Herba Cistanches 2 ~ 8 parts, Rhizoma Panacis Japonici 8 ~ 12 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 3 ~ 12 parts, Carapax Et Plastrum Testudinis 6 ~ 9 parts, Radix Polygoni Multiflori 2 ~ 3 parts.
Described instant particles as Chinese medicine is obtained by following step:
(1) take Radix Pseudostellariae, Radix Glycyrrhizae Preparata, Folium Crataegi, Rhizoma Panacis Japonici according to parts by weight, add in the water of 10 times of weight and decoct 2 ~ 10h, filter, filtrate is condensed into thick paste;
(2) in step (1) gained thick paste, add the sucrose relative to thick paste 0.5 ~ 1 times, the dextrin of 0.5 ~ 2 times, and by surplus stock silkworm compound amino acid powder, Radix Achyranthis Bidentatae, Lentinus Edodes, Herba Cistanches, Hericium erinaceus (Bull. Ex Fr.) Pers., Carapax Et Plastrum Testudinis, Ganoderma, join in thick paste, stir, lyophilization, is ground into fine powder, obtained mixed powder;
(3) mixed powder of step (2) gained is placed on fluid bed granulator granulates, pack, obtained described instant particles as Chinese medicine.
Described herbal raw material is dried powder, and cross 80 mesh sieves, water content is 10 ~ 15%.
In described step (2), the relative density of thick paste is 1.35 ~ 1.5.
In described step (2), cryodesiccated condition is freezing 6 ~ 12h at-5 ~-2 DEG C.
In described step (3), the specification of pack is 7 ± 0.33 grams/bag.
The production process of described step (1) ~ (3) all operates under 300,000 grades of production clean area conditions.
The technique effect that the present invention is useful is:
1, Radix Glycyrrhizae Preparata, Radix Polygoni Multiflori and Folium Crataegi in electuary of the present invention are the Chinese herbal medicine of the effect with reducing blood pressure and blood fat.
2, in electuary of the present invention, Lentinus Edodes is high protein, low-fat nutritional health food, and lentinan (β ~ 1,3 glucosans) can strengthen cell immunocompetent, thus the growth of anticancer; Lentinus Edodes contains more than 40 kind of enzyme of six large enzymes, can correct human chitinase deficiency disease; Institute's fatty acids, reduces blood fat to human body useful.
3, in electuary of the present invention, Hericium erinaceus (Bull. Ex Fr.) Pers., containing unsaturated fatty acid, can reduce cholesterolemia and content of triglyceride, adjusting blood lipid, be beneficial to blood circulation; Ganoderma can coronary artery dilator, increases coronary flow, reduces cholesterolemia, lipoprotein and triglyceride, the formation of prevention of arterial atherosclerotic plaque.
4, the Chinese herbal medicine playing effect for reducing fat in electuary of the present invention coordinates the amino acid whose silkworm compound amino acid with 18 kinds of needed by human, in reducing blood pressure and blood fat, there is remarkable result, coordinate the Chinese herbal medicine of other number taste vigorate qi and replenish the blood, strengthening the tendons and bones, while raising human mechanism, better can play effect of reducing blood pressure and blood fat.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is specifically described.
Embodiment 1
An instant particles as Chinese medicine for auxiliary antilipemic, is obtained by following step:
(1) take Radix Pseudostellariae 6 parts, Radix Glycyrrhizae Preparata 20 parts, Folium Crataegi 12, Rhizoma Panacis Japonici 10 parts according to parts by weight, add in the water of 10 times of weight and decoct 2h, filter, filtrate is condensed into thick paste (relative density is 1.35);
(2) in step (1) gained thick paste, add the sucrose relative to thick paste 0.5 times, the dextrin of 2 times, and by 5 parts, surplus stock silkworm compound amino acid powder, Radix Achyranthis Bidentatae 10 parts, 20 parts, Lentinus Edodes, Herba Cistanches 2 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 3 parts, Carapax Et Plastrum Testudinis 9 parts, Radix Polygoni Multiflori 3 parts, join in thick paste, stir, lyophilization, is ground into fine powder, obtained mixed powder; Cryodesiccated condition is freezing 6h at being-5 DEG C;
(3) mixed powder of step (2) gained is placed on fluid bed granulator granulates, pack (7 ± 0.33 grams/bag), obtained described instant particles as Chinese medicine.
Described herbal raw material is dried powder, and cross 80 mesh sieves, water content is 10%.
The production process of described step (1) ~ (3) all operates under 300,000 grades of production clean area conditions.
Embodiment 2
An instant particles as Chinese medicine for auxiliary antilipemic, is obtained by following step:
(1) take Radix Pseudostellariae 20 parts, Radix Glycyrrhizae Preparata 12 parts, Folium Crataegi 8, Rhizoma Panacis Japonici 8 parts according to parts by weight, add in the water of 10 times of weight and decoct 8h, filter, filtrate is condensed into thick paste (relative density is 1.4);
(2) in step (1) gained thick paste, add the sucrose relative to thick paste 1 times, the dextrin of 0.5 times, and by 4 parts, surplus stock silkworm compound amino acid powder, Radix Achyranthis Bidentatae 15 parts, 6 parts, Lentinus Edodes, Herba Cistanches 6 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 12 parts, Carapax Et Plastrum Testudinis 8 parts, Radix Polygoni Multiflori 3 parts, join in thick paste, stir, lyophilization, is ground into fine powder, obtained mixed powder; Cryodesiccated condition is freezing 12h at being-2 DEG C;
(3) mixed powder of step (2) gained is placed on fluid bed granulator granulates, pack (7 ± 0.33 grams/bag), obtained described instant particles as Chinese medicine.
Described herbal raw material is dried powder, and cross 80 mesh sieves, water content is 12%.
The production process of described step (1) ~ (3) all operates under 300,000 grades of production clean area conditions.
Embodiment 3
An instant particles as Chinese medicine for auxiliary antilipemic, is obtained by following step:
(1) take Radix Pseudostellariae 12 parts, Radix Glycyrrhizae Preparata 18 parts, Folium Crataegi 16, Rhizoma Panacis Japonici 12 parts according to parts by weight, add in the water of 10 times of weight and decoct 10h, filter, filtrate is condensed into thick paste (relative density is 1.5);
(2) in step (1) gained thick paste, add the sucrose relative to thick paste 0.7 times, the dextrin of 1 times, and by 2 parts, surplus stock silkworm compound amino acid powder, Radix Achyranthis Bidentatae 12 parts, 15 parts, Lentinus Edodes, Herba Cistanches 8 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 8 parts, Carapax Et Plastrum Testudinis 6 parts, Radix Polygoni Multiflori 2 parts, join in thick paste, stir, lyophilization, is ground into fine powder, obtained mixed powder; Cryodesiccated condition is freezing 8h at being-3 DEG C;
(3) mixed powder of step (2) gained is placed on fluid bed granulator granulates, pack (7 ± 0.33 grams/bag), obtained described instant particles as Chinese medicine.
Described herbal raw material is dried powder, and cross 80 mesh sieves, water content is 10%.
The production process of described step (1) ~ (3) all operates under 300,000 grades of production clean area conditions.
Test example:
Laboratory animal and grouping: SPF level Kunming kind female mice, body weight 18g ~ 22g, by east, Changsha Kaifu District, wound experimental animal science service portion provides, and production licence number is SCXK (Hunan) 2009-0012.Feedstuff is provided by same unit.Under experimental enviroment, mice feeds normal feedstuff 5d, gets fasting blood, measure its Triglycerides in Serum, cholesterol, HDL-C respectively through eye socket.Consider the level of triglyceride according to blood cholesterol level, be divided into 4 groups at random, often organize 10, be respectively high fat matched group, basic, normal, high dosage group, often group is unified feeds high lipid food.
Test method: the instant particles as Chinese medicine that embodiment 1 ~ 3 is obtained, each adult often takes 2 times day by day, each 1 bag (7 ± 0.33 grams), convert according to adult human body weight 50kg, be equivalent to 0.14g/kg, while nursing high lipid food, give basic, normal, high dosage group mice embodiment 3 obtained electuary of the present invention by the amount of its 5 times (0.7g/kg), 10 times (1.4g/kg), 30 times (4.2g/kg) respectively, orally to give, every day 2 times; High fat matched group only gives high lipid food and does not do other process.Test period is 28d, and therebetween, weigh in weekly, 28d gets blood through eye socket, measures triglyceride, cholesterol, HDL-C.Triglyceride phosphoglycerol oxidizing process, cholesterol enzyme assay, the HDL-C sedimentation method.Test result is as shown in table 1,2.
More than measure with Lisa 500Plus automatic clinical chemistry analyzer, adopt the SPINREACT test kit that SPAIN provides.
Table 1
Note: " * " compares with high fat matched group, P < 0.05.
Table 2
Note: " * " compares with high fat matched group, P < 0.05.
With the continuous 28d of the dosage of 0.7g/kg, 1.4g/kg, 4.2g/kg respectively oral give basic, normal, high Dose Groups Study mice after, lipid determination is carried out to it.Can be found out by result in table 1, in basic, normal, high dosage group Mouse Blood, triglyceride and cholesterol level are all starkly lower than high fat matched group, and wherein the cholesterol levels of basic, normal, high dosage group is respectively 27.2%, 35.6%, 40.1% relative to the reduction amplitude of high fat matched group.
As can be seen from institute's column data in table 2, high dose group HDL-C content is apparently higher than high fat matched group, and elevation amplitude is 41.0%, shows that product has regulating blood lipid action.
Claims (7)
1. an instant particles as Chinese medicine for auxiliary antilipemic, is characterized in that being made up of the herbal raw material of following parts by weight: 2 ~ 5 parts, silkworm compound amino acid powder, Radix Pseudostellariae 6 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts, Radix Glycyrrhizae Preparata 12 ~ 20 parts, 6 ~ 20 parts, Lentinus Edodes, Folium Crataegi 8 ~ 16 parts, Herba Cistanches 2 ~ 8 parts, Rhizoma Panacis Japonici 8 ~ 12 parts, Hericium erinaceus (Bull. Ex Fr.) Pers. 3 ~ 12 parts, Carapax Et Plastrum Testudinis 6 ~ 9 parts, Radix Polygoni Multiflori 2 ~ 3 parts.
2. instant particles as Chinese medicine according to claim 1, is characterized in that being obtained by following step:
(1) take Radix Pseudostellariae, Radix Glycyrrhizae Preparata, Folium Crataegi, Rhizoma Panacis Japonici according to parts by weight, add in the water of 10 times of weight and decoct 2 ~ 10h, filter, filtrate is condensed into thick paste;
(2) in step (1) gained thick paste, add the sucrose relative to thick paste 0.5 ~ 1 times, the dextrin of 0.5 ~ 2 times, and by surplus stock silkworm compound amino acid powder, Radix Achyranthis Bidentatae, Lentinus Edodes, Herba Cistanches, Hericium erinaceus (Bull. Ex Fr.) Pers., Carapax Et Plastrum Testudinis, Ganoderma, join in thick paste, stir, lyophilization, is ground into fine powder, obtained mixed powder;
(3) mixed powder of step (2) gained is placed on fluid bed granulator granulates, pack, obtained described instant particles as Chinese medicine.
3. instant particles as Chinese medicine according to claim 1, is characterized in that described herbal raw material is dried powder, and cross 80 mesh sieves, water content is 10 ~ 15%.
4. instant particles as Chinese medicine according to claim 2, is characterized in that the relative density of thick paste in described step (2) is 1.35 ~ 1.5.
5. instant particles as Chinese medicine according to claim 2, is characterized in that in described step (2), cryodesiccated condition is freezing 6 ~ 12h at-5 ~-2 DEG C.
6. instant particles as Chinese medicine according to claim 2, is characterized in that the specification of pack in described step (3) is 7 ± 0.33 grams/bag.
7. instant particles as Chinese medicine according to claim 2, is characterized in that the production process of described step (1) ~ (3) all operates under 300,000 grades of production clean area conditions.
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| CN101406295A (en) * | 2008-09-08 | 2009-04-15 | 赵兴坤 | Total nutrient silkworm chrysalis peptide functional foodstuff and preparation method thereof |
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| CN103652879A (en) * | 2013-11-29 | 2014-03-26 | 青岛海发利粮油机械有限公司 | Health-care food with blood lipid reducing function |
| CN103751591A (en) * | 2014-01-05 | 2014-04-30 | 张磊 | Preparation method of traditional Chinese medicine for treating hyperlipemia caused by deficiency of both yin and yang |
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| CN101406295A (en) * | 2008-09-08 | 2009-04-15 | 赵兴坤 | Total nutrient silkworm chrysalis peptide functional foodstuff and preparation method thereof |
| CN102106957A (en) * | 2011-03-24 | 2011-06-29 | 于庆德 | Chinese medicinal composition for treating hyperlipidemia |
| CN103652879A (en) * | 2013-11-29 | 2014-03-26 | 青岛海发利粮油机械有限公司 | Health-care food with blood lipid reducing function |
| CN103751591A (en) * | 2014-01-05 | 2014-04-30 | 张磊 | Preparation method of traditional Chinese medicine for treating hyperlipemia caused by deficiency of both yin and yang |
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