CN101244084B - Sobering-up agent of pearl oyster and preparation thereof - Google Patents

Sobering-up agent of pearl oyster and preparation thereof Download PDF

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Publication number
CN101244084B
CN101244084B CN2008100259538A CN200810025953A CN101244084B CN 101244084 B CN101244084 B CN 101244084B CN 2008100259538 A CN2008100259538 A CN 2008100259538A CN 200810025953 A CN200810025953 A CN 200810025953A CN 101244084 B CN101244084 B CN 101244084B
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agent
pearl oyster
minutes
water
oyster meat
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CN101244084A (en
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章超桦
高加龙
秦小明
洪鹏志
吉宏武
曹文红
刘书成
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Guangdong Ocean University
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Guangdong Ocean University
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention provides a pearl oyster meat disintoxicating agent and the preparation method; wherein, the preparation method comprises the following steps: the pearl oyster meat is added to 4 to 8 time amount of water and is homogenized and ground; then the pH value is adjusted to 5 to 8. One or a plurality of proteinase of 0.2 to 2% pearl oyster meat quality is added; the enzymolysis is made under the temperature of 40 to 65 DEG C in 5 to 8 hours and the stirring is continued in the process; the enzyme is killed in the boiling water for 10 minutes; the extraction is made in hot water of 60 to 100 DEG C for 20 to 40 minutes; the residue is filtered out; the filtered liquid is concentrated and spray dried to powder; the original powder of pearl oyster meat disintoxicating agent is obtained. The powder can be produced into tablet, capsule and oral liquid. The pearl oyster meat disintoxicating agent has the advantage that the alcohol relieving and liver protecting effect is excellent; the product can reduce the intoxication rate of a mouse from 90% to 20%, shorten nearly 200 minutes of the intoxication sleep time of the mouse, and obviously reduce the alcohol concentration in blood of the mouse.

Description

A kind of sobering-up agent of pearl oyster meat and preparation method thereof
Technical field
The present invention relates to a kind of antialcoholism function product and biological enzymolysis preparation method thereof, belong to functional health and biological technical field.
Background technology
According to incompletely statistics, the nearly 300,000,000 wine people of China, and popularity of wine is in rising trend always in recent years.Annual then have and surpass 200,000 people and die from alcoholism.In the face of high alcoholism mortality rate like this, the antidote of seeking to relieve the effect of alcohol safely and effectively has been the present task of top priority of people.
It is generally acknowledged ethanol by two independently metabolic pathway be oxidized to acetaldehyde, acetaldehyde is oxidized to acetic acid through the aldehyde dehydrogenase (ALDH) that is present in the liver cell mitochondria again.Article one, be ethanol dehydrogenase (ADH) approach, this approach is present in the cytoplasm of liver liquid, under the catalysis of ADH, is acetaldehyde with oxidation of ethanol, and this enzyme (is called for short NAD with nicotinamide adenine dinucleotide +) make cofactor.Another is MEOS (MEOS) approach, and this system is present in the hepatomicrosome, needs cytochrome P 450Existence and the participation of nicotinamide-adenine dinucleotide phosphate (NADPH).
Some scientific and technical literatures have been announced the medicine and preparation method thereof that much relieves the effect of alcohol in recent years, as:
1, Chinese patent＜application number〉03106222.9＜denomination of invention〉a kind of relieving the effect of alcohol, medicine of sobering up and preparation method thereof＜applicant〉Zhou Yungang＜summary〉the present invention relates to a kind of relieving the effect of alcohol, medicine of sobering up and preparation method thereof, it is characterized in that by weight with Hovenia acerba Lindl. 10-100 part, Flos puerariae lobatae 8-70 part, Dracontomelon dao 8-70 part or Hovenia acerba Lindl. 10-100 part, Flos puerariae lobatae 8-70 part, Dracontomelon dao 8-70 part, Radix Puerariae 5-60 part, Radix Glycyrrhizae 5-60 part, after Radix Angelicae Sinensis 5-50 part is mixed, with roselle 1-10 part, after making medicinal liquid by the decocting method of Chinese medicine, the weight ratio of pressing medicinal liquid adds suspending agent 0.5-0.8%, sterilization, fill, seal the inversion downwards of back bottleneck and deposit natural cooling.Its advantage is to drink this medicine before drinking, can increase capacity for liquor, drinking this medicine after drinking can relieve the effect of alcohol rapidly, take checking through many people, effect is very remarkable, generally relieves the effect of alcohol substantially after 20-30 minute, and number of people NAOQING is waken up, and this medicine has the stomach function regulating hepatoprotective, dryout, the effect of mediation the five internal organs.Be the crowd's of drinking health care good medicine.
2, Chinese patent＜application number〉02104037.0＜denomination of invention〉a kind of medical composition and its use＜applicant with effects of relieving alcoholism and protecting liver〉Cheng Yanjie; Li Qiang＜summary〉the present invention relates to a kind of have relieve the effect of alcohol, the pharmaceutical composition of hepatoprotective effect, it is a raw material with Fructus Gardeniae, Fructus Chaenomelis, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Semen Vitis viniferae, through being processed into the product of tool effects of relieving alcoholism and protecting liver, this product has the toxicity of the effect of heat-clearing and toxic substances removing, the blood stasis dispelling of stomach function regulating dampness dissipating, QI regulating with system wine.Having through experimentation proof increases the tolerance of human body to ethanol, reduces headache, headache due to the ethanol, feels sick, vomiting, gastric discomfort, reduces ethanol to the formed damage of liver, the effect of treatment fatty liver.Can be made into that tool relieves the effect of alcohol, the medicine of hepatoprotective effect or health food, other based food, health product.
3, Chinese patent＜application number〉02110426.3＜denomination of invention〉relieve the effect of alcohol and preventing drunkenness Chinese medicine preparation and preparation method thereof＜applicant Lei Shichang＜summary the present invention relates to the Chinese medicine health-care preparation, be specifically related to a kind of relieving the effect of alcohol and the preventing drunkenness Chinese medicine preparation; The invention still further relates to the preparation method of this medicine; This relieves the effect of alcohol and comprises Semen Hoveniae (Fructus Hoveniae) or the Caulis Bambusae In Taenia of 3-6 or the Radix Changii of 9-15 of 10-30, the Flos puerariae lobatae of 10-30 or the Radix Puerariae of 10-30, Cortex Moutan 10-30 with the preventing drunkenness Chinese medicine preparation by weight, Radix Glycyrrhizae 3-6, Fructus Crataegi 9-20, Endothelium Corneum Gigeriae Galli 3-12, Fructus Hordei Germinatus 6-20, Rhizoma Phragmitis 15-30, Semen Plantaginis 9-15.It is good that Dealcoholic sobering-up of the present invention is removed the alcoholism effect, is convenient to preserve, carry.
4, Chinese patent＜application number〉95100073.X＜denomination of invention〉a kind of relieving the effect of alcohol and the preparation of preventing drunkenness and preparation method thereof＜applicant〉Yuan Changhai＜summary〉the invention discloses a kind of Chinese medicine preparation that is used to relieve the effect of alcohol etc., said preparation is by refining forming such as Flos puerariae lobatae, Radix Puerariae, Poria, the Radix Aucklandiae, Radix Asparagi, Fructus Amomi, Radix Ginseng, Cortex Moutans, this product prescription is peculiar, and compatibility is precise and appropriate.Rapid, reliable for effect as the Chinese medicine drug effect that relieves the effect of alcohol; Take before the wine and can obviously improve the toleration of people ethanol.Be used for carsick seasick instant effect, do not have drowsiness phenomenon.Preparation of the present invention does not have any toxicity, side effect.
5, Chinese patent＜application number〉02154140.X＜denomination of invention〉vegetable composition Dealcoholic sobering-up electuary and preparation method thereof＜applicant〉Wang Wuding＜summary〉the invention discloses a kind of vegetable composition Dealcoholic sobering-up electuary and preparation method thereof, this electuary is mixed by the micron powder of these six kinds of raw materials of Flos Caryophylli of 25～30% Radix Puerariae, 25～30% Semen Hoveniae (Fructus Hoveniae), 20～25% Poria, 10～15% Fructus Schisandrae Chinensis, 8～10% green tea and 2～3% by weight ratio.The micron powder particle diameter of each raw material is preferable 5～15 microns scope, scope the best of 5～10 microns.Its preparation method may further comprise the steps: at first with Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Poria, Fructus Schisandrae Chinensis, green tea, these six kinds of raw materials of Flos Caryophylli mix homogeneously by weight proportion, be ground into the coarse powder mixture; Then with this coarse powder mixture through the powder body micronizing device processes, make it become the micron powder mixture; Add an amount of excipient, correctives and suspensoid again, conventional granulation, oven dry, granulate; Last packing gets final product.Synergism between its effective ingredient-use rate height, the component is good, can obviously eliminate or alleviate the various ill symptomses of drinking and causing rapidly.
6, Chinese patent＜application number〉03146404.1＜denomination of invention〉relieving alcoholism and protecting the liver liquid product and production method＜applicant thereof〉Yonglongshan Biotechnology Co., Ltd., Zhuji City＜summary〉a kind of relieving alcoholism and protecting the liver liquid product and production method thereof, it mainly comprises following compositions in portion by weight composition: comprehensive vegetables and fruits fermenation raw liquid 40-70 part, chitin poly oligosaccharide stock solution 10-30 part and rice vinegar 10-30 part, this comprehensive vegetables and fruits fermenation raw liquid and chitin poly oligosaccharide fermenation raw liquid are respectively multiple vegetables and fruits and chitosan to be cultivated by probiotic bacteria and yeast inoculation fermentation, produce the fermenation raw liquid and the chitin poly oligosaccharide fermenation raw liquid of comprehensive vegetables and fruits.Effect with effective relieving alcoholism and protecting the liver.
Recognize that from above-mentioned retrieval the medicine that relieves the effect of alcohol mostly is prepared from by Chinese herbal medicine or traditional proved recipe, can the metabolism of acceleration of alcohol in human body, the various malaise symptoms that alleviating drinks causes.But there is bad smell in Chinese herbal medicine, if be difficult to accept as the food consumption person.And the method for utilizing aquatic products to prepare Medicament for Alcoholism is not also reported.
" in the silt at shellfish end because it is dived under water for a long time, sea water more helps it salty-cold, and therefore, shellfish has effects such as clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, tranquillizing and allaying excitement, hard masses softening and resolving and suppressing the hyperactive liver and subsiding YANG mostly." Carnis Margarita is nutritious, the protein content height contains inorganic salt and trace element such as abundant taurine, EPA, DHA and calcium, phosphorus, ferrum, zinc, manganese, magnesium.Utilize the Carnis Margarita exploitation to have the health food and the extraction active constituents of medicine of high nutritive value, very big potentiality to be exploited is arranged.
Summary of the invention
The objective of the invention is mostly to be Chinese herbal medicine greatly at the existing disintoxicating product in current market, and the single characteristics of product variety, adopt biological enzymolysis technology, by-product Carnis Margarita with pearl culture is a raw material, provide a kind of can be by the human body fast Absorption, make rapid antialcoholic sobering-up agent of pearl oyster meat of people and preparation method thereof.
The Medicament for Alcoholism of utilizing the Carnis Margarita preparation of the present invention, its raw material is the by-product Carnis Margarita of pearl culture.Its leaching process is:
1,1 portion of Carnis Margarita adds 4-8 part water, broken homogenate;
2, regulating pH value is 5-8, adds the protease of 0.2-2% shellfish meat quality, in 40-65 ℃ water-bath enzymolysis 2-9 hour, during constantly stir, the boiling water bath enzyme denaturing is 10 minutes then;
3, reuse 60-100 ℃ hot water extraction 20-40 minute, filtration residue;
4, filtered solution is through concentrating, and spraying drying powder-forming is the former powder of Medicament for Alcoholism.
The used enzyme of this Medicament for Alcoholism preparation process is one or more in pepsin, neutral protease, papain, animal proteinum compound enzyme, the trypsin.
The method of described shellfish meat enzymolysis adopts one of following scheme:
1, regulating pH value is 5-8, adds the protease of 0.4-1.0% shellfish meat quality, in 40-65 ℃ water-bath enzymolysis 2-5 hour, during constantly stir, the boiling water bath enzyme denaturing is 10 minutes then; Treat when temperature is reduced to below 40 ℃ to add the another kind of protease of 0.4-1.0% shellfish meat quality, in 40-65 ℃ water-bath enzymolysis 2-5 hour, during constantly stir, the boiling water bath enzyme denaturing is 10 minutes then;
2, regulating pH value is 5-8, the protease that adds 0.4-1.0% shellfish meat quality, in 40-65 ℃ water-bath enzymolysis 2-5 hour, constantly stir during this time, the another kind of protease that adds 0.4-1.0% shellfish meat quality again, in 40-65 ℃ water-bath enzymolysis 2-5 hour, during constantly stir, the boiling water bath enzyme denaturing is 10 minutes then;
3, regulating pH value is 5-8, adds the protease (one or both) of 0.4-2.0% shellfish meat quality, in 40-65 ℃ water-bath enzymolysis 3-6 hour, during constantly stir, the boiling water bath enzyme denaturing is 10 minutes then.
The former powder of this Medicament for Alcoholism is easy to use, can add in a lot of products with multi-form.As: add various adjuvants, can be canned for capsule or be pressed into tablet; Also oral liquid is made in seasoning after the solubilized; Can also add to and make functional food with effects of relieving alcoholism and protecting liver etc. in food, the beverage.
The present invention has following advantage:
1, the Carnis Margarita of the present invention's employing is the by-product of pearl culture, and it is very extensive to originate, and cheap, and production cost is low.
2, Carnis Margarita is nutritious, has hepatoprotective, calms the nerves, effect such as heat-clearing and toxic substances removing.
3, this Medicament for Alcoholism is absorbed by health easily, has no side effect, and is safe; And easy to use, can make the product of various ways.
The specific embodiment
The present invention is described further in conjunction with the implementing process example:
Embodiment 1
1, preparation Medicament for Alcoholism former powder: raw shellfish meat 1000g → add 6000mL water, homogenate → adjusting pH is 7 → add 0.45% animal proteinum compound enzyme, enzymolysis is 4 hours in 55 ℃ of water-baths, constantly stirrings → boiling water bath enzyme denaturing 10 minutes → regulate pH after cooling is 7.8 → adding, 1.5% trypsin, in 45 ℃ of water-baths enzymolysis 2-4 hour, constantly 40 minutes → filtration residue of 10 minutes → 100 ℃ hot water extraction of stirring → boiling water bath enzyme denaturing concentrates filtered solution, the former powder of spray drying → Medicament for Alcoholism.
2, anti-intoxication animal experiment
Test material: high, medium and low dosage " sobering-up agent of pearl oyster meat ", the former powder of Medicament for Alcoholism is dissolved in water is variable concentrations; 56 ° of Red Star strong, colourless liquor distilled from sorghum; Male SPF level mice.
Method: white mice is divided into 4 groups at random by body weight, and 10 every group, irritate " sobering-up agent of pearl oyster meat " of stomach normal saline, high, medium and low dosage respectively, behind the 30min, 4 groups of mices are all irritated stomach with 56 ° Red Star strong, colourless liquor distilled from sorghum.Write down drunk number of elements and mice righting reflex loss time and recovery time, calculate tolerance time (from irritating the time of stomach ethanol) and drunk hold time (from the righting reflex loss to the recovery time) to the righting reflex complete obiteration.
The result: the drunk after drinking rate of negative control group filling of irritating the stomach normal saline is 90%, irritates average after drinking 20.5 minutes righting reflex loss, and on average keeps 413.5 minutes sides and recover righting reflex; Irritate the mice after the stomach Medicament for Alcoholism, the drunk rate of high dose group has been reduced to 20%, in, low dose group has been reduced to 50%; The tolerance time of high dose group has then extended to 77.7 minutes, holds time also to have shortened to about 200 minutes.The result shows that high, medium and low dosage " sobering-up agent of pearl oyster meat " all can reduce drunk number of elements, prolongs tolerance time, and shortens and hold time, and plays the effect of pre-preventing drunkenness.
Embodiment 2
1, preparation Medicament for Alcoholism former powder: raw shellfish meat 1000g → add 7000mL water, homogenate → adjusting pH is 7 → add 0.65% neutral protease, enzymolysis is 4 hours in 50 ℃ of water-baths, constantly stir → add 0.4% papain then, enzymolysis is 3.5 hours in 45 ℃ of water-baths, constantly 30 minutes → filtration residue of 10 minutes → 80 ℃ hot water extraction of stirring → boiling water bath enzyme denaturing concentrates filtered solution, the former powder of spray drying → Medicament for Alcoholism.
2, the animal experiment that relieves the effect of alcohol
Test material: high, medium and low dosage " sobering-up agent of pearl oyster meat ", the former powder of Medicament for Alcoholism is dissolved in water is variable concentrations; 56 ° of Red Star strong, colourless liquor distilled from sorghum; Male SPF level mice.
Method: white mice is divided into 4 groups at random by body weight, and 10 every group, 4 groups of mices are all irritated stomach with the Red Star strong, colourless liquor distilled from sorghum, irritate perfusion immediately after drinking, 4 groups of " sobering-up agent of pearl oyster meat " of irritating stomach normal saline, high, medium and low dosage respectively.Write down drunk number of elements and mice righting reflex loss time and recovery time, calculate tolerance time and drunk holding time.
The result: the drunk after drinking rate of negative control group filling of irritating the stomach normal saline is 90%, irritates average after drinking 10.5 minutes righting reflex loss, and on average keeps 322 minutes sides and recover righting reflex; Mice after the filling stomach Medicament for Alcoholism, the drunk rate of high, middle dosage group has been reduced to 40%, and low dose group has been reduced to 50%; The tolerance time of high dose group has then extended to 73.5 minutes, holds time and has also shortened about 114 minutes than negative control group.The result shows that high, medium and low dosage " sobering-up agent of pearl oyster meat " all can reduce drunk number of elements, prolongs tolerance time, and shortens and hold time, and plays the effect of relieving the effect of alcohol of highly significant.
Embodiment 3
1, preparation Medicament for Alcoholism former powder: raw shellfish meat 1000g → add 8000mL water, homogenate → adjusting pH is 7 → add the enzymolysis of 0.45% neutral protease, 0.65% animal proteinum compound enzyme → in 50 ℃ of water-baths 4 hours, continuous 40 minutes → filtration residue of 10 minutes → 80 ℃ hot water extraction of stirring → boiling water bath enzyme denaturing, concentrate filtered solution, the former powder of spray drying → Medicament for Alcoholism.
2, determining concentration of alcohol in the mouse blood after drinking
Test material: high and low dose " sobering-up agent of pearl oyster meat ", the former powder of Medicament for Alcoholism is dissolved in water is variable concentrations; 56 ° of Red Star strong, colourless liquor distilled from sorghum; Male SPF level mice.
Method: 100 of mices, by body weight random packet, normal saline group, " sobering-up agent of pearl oyster meat " high dose group and " sobering-up agent of pearl oyster meat " low dose group, every group each 30,10 of blank groups.Irritate stomach normal saline, high and low concentration " sobering-up agent of pearl oyster meat " respectively, all irritate 56 ° of Red Star strong, colourless liquor distilled from sorghum of stomach behind the 30min.Respectively get 5 mices from each group and pluck eyeball and get blood from irritating after drinking different time, the blank group is not done any filling stomach and is directly plucked eyeball and get blood.Centrifugal blood is got top serum gas Chromatographic Determination.
Result: 30 minutes after drinking, concentration of alcohol has only about 40% of negative control group in the high dose group mouse blood, low dose group blood determining alcohol has only about 70% of negative control group, prolongation along with the time, in 180 minutes, the blood determining alcohol of high and low dose group is lower than negative control group all the time, and " Medicament for Alcoholism " that high and low dose is described all can significantly reduce the concentration of alcohol in the blood, plays the effect of well relieving the effect of alcohol.
Embodiment 4
1, preparation Medicament for Alcoholism former powder: raw shellfish meat 1000g → add 6000mL water, homogenate → adjusting pH is 7 → add 0.45% neutral protease, enzymolysis is 3.5 hours in 50 ℃ of water-baths, constantly stir → add 0.7% papain then, enzymolysis is 4 hours in 45 ℃ of water-baths, constantly 25 minutes → filtration residue of 10 minutes → 85 ℃ hot water extraction of stirring → boiling water bath enzyme denaturing concentrates filtered solution, the former powder of spray drying → Medicament for Alcoholism.
2, the anti-chmice acute alcoholic liver injury test of " Medicament for Alcoholism "
Test material: high, medium and low dosage " sobering-up agent of pearl oyster meat ", the former powder of sobering-up agent of pearl oyster meat are dissolved in water and are variable concentrations; 56 ° of Red Star strong, colourless liquor distilled from sorghum; Male SPF level mice.
Method: mice is divided into negative control group, high, medium and low dosage group and blank group (normal group).4 groups of mouse except that the blank group, fasting every day be can't help water and irritate stomach Chinese liquor, behind the 0.5h, irritate " sobering-up agent of pearl oyster meat " of stomach normal saline, high, medium and low dosage respectively.Continuous modeling and one week of administration.
After one week mice is plucked eyeball and get blood, be kept in the anticoagulant tube, measure aspartate aminotransferase (AST), alanine aminotransferase (ALT), T-CHOL (CHOL) and the triglyceride (TG) of serum with automatic clinical chemistry analyzer.
Result: each index of the mice serum of analysis of biochemical analysis-e/or determining, (A) compares with negative control group, each administration group mice serum AST, ALT, CHOL, TG index all significantly descend, illustrate and can suppress " sobering-up agent of pearl oyster meat " to drink AST, ALT, CHOL, TG rise in the blood of back to have the effect of good anti-acute alcohol liver damage.

Claims (2)

1. sobering-up agent of pearl oyster meat is characterized in that its leaching process is:
(1) 1 portion of Carnis Margarita adds 4-8 part water, broken homogenate;
(2) regulating pH value is 5-8, adds the protease of 0.4-1.0% shellfish meat quality, in 40-65 ℃ water-bath enzymolysis 2-5 hour, during constantly stir, the boiling water bath enzyme denaturing is 10 minutes then; Treat when temperature is reduced to below 40 ℃ to add the another kind of protease of 0.4-1.0% shellfish meat quality, in 40-65 ℃ water-bath enzymolysis 2-5 hour, during constantly stir, the boiling water bath enzyme denaturing is 10 minutes then;
(3) reuse 60-100 ℃ hot water extraction 20-40 minute, filtration residue;
(4) filtered solution is through concentrating, and spraying drying powder-forming is the former powder of Medicament for Alcoholism, makes the Medicament for Alcoholism of tablet, capsule, drink form with this former powder;
Wherein said protease is a kind of in pepsin, neutral protease, papain, the trypsin.
2. a kind of sobering-up agent of pearl oyster meat according to claim 1 is characterized in that raw material is the by-product Carnis Margarita of pearl culture.
CN2008100259538A 2008-01-16 2008-01-16 Sobering-up agent of pearl oyster and preparation thereof Active CN101244084B (en)

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CN101982114B (en) * 2010-09-26 2012-07-25 广东海洋大学 Method for producing anti-fatigue oral liquids by using Pinctada martensii dunker meats
CN104939095A (en) * 2015-06-12 2015-09-30 蚌埠市丰牧牛羊肉制品有限责任公司 De-alcoholic capsules
CN109691645A (en) * 2018-12-19 2019-04-30 庞雁 A kind of preparation method of the pearl oyster meat breaking-wall cell solution of no triethylamine bad smell
CN111387438A (en) * 2020-03-27 2020-07-10 荣成市敬阳生物科技有限公司 Extraction method and application of active ingredients of marine product by-products

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