CN100484542C - Chinese medicinal compound recipe for treating osteoporosis and its preparing process - Google Patents
Chinese medicinal compound recipe for treating osteoporosis and its preparing process Download PDFInfo
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- CN100484542C CN100484542C CNB2004100211210A CN200410021121A CN100484542C CN 100484542 C CN100484542 C CN 100484542C CN B2004100211210 A CNB2004100211210 A CN B2004100211210A CN 200410021121 A CN200410021121 A CN 200410021121A CN 100484542 C CN100484542 C CN 100484542C
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Abstract
The present invention is the recipe and preparation process of osteoporosis treating Chinese medicine, and the medicine features less toxic side effect and safety in use. The medicine is prepared with epimedium 5-50 wt%, drynaria rhizome 5-50 wt%, cnidium fruit 5-50 wt%, and red sag 5-50 wt%. The technological process of preparing the medicine includes thrice extracting dried medicine material with solvent of 6-10 times via heating at the boiling point of the solvent for 1-3 hr each, merging the extractive liquid, concentration, drying and crushing into fine powder. The process is scientific, stable and suitable for industrial production, and the present invention provides one new way for treating osteoporosis.
Description
Technical field:
The present invention relates to medical technical field, exactly it is a kind of tcm small compound prescription that is used for the treatment of osteoporosis and preparation method thereof.
Background technology:
Osteoporosis is to deteriorate to main pathological characters with minimizing of whole body bone amount and osseous tissue microstructure, so that the fragility of bone increases and a kind of general metabolism osteopathia of fracture risk increase, it is mainly seen in middle-aged and elderly people, shortens to main performance with osteodynia, easy fracture, height.Can be divided into primary osteoporosis and secondary osteoporosis two major types at present: primary osteoporosis is to reduce and fracture is a feature with bone mineral content, accounts for more than 95% of sickness rate, is common one type; Insecondary osteoporosis accounts for 5% of sickness rate, is mainly caused as renal osteodystrophy, hyperthyroidism, diabetes and acidosis and iatrogenic disease etc. by various diseases.
Development along with society, the aging trend of world population is more and more obvious, osteoporosis has become global old epidemic diseases of a kind of 21st century, its sickness rate obviously increases, and Chinese gerontology can osteoporosis association forecast China patients with osteoporosis number to 2010 year be about 1.14 hundred million people (accounting for total population 8.2%); Be about 1.51 hundred million people (accounting for total population 9.9%) in 2025.Annual number because of the concurrent fracture of osteoporosis also will remain high with the double-digit growth rate, and the Health and Living quality that this will seriously threaten the old people becomes following medical treatment and social significant problem.
The treatment to osteoporosis at present mainly relies on Drug therapy, but it is found that existing chemicals has much not person of modern times's part of anticipating.As life-time service side effect big (as estrogen etc.), late result (as fluoride etc.), cost an arm and a leg (as active vitamin, calcitonin etc.) etc. uncertainly.Discovery Chinese medicine is compared with Western medicine in the clinical and pharmacological research of Chinese herb prevention osteoporosis, has the advantage of obvious safe, low toxic and side effects.Therefore, advantage how to bring into play Chinese medicine in protect against osteoporosis is a significant problem, and the Chinese medicine of actively developing the treatment osteoporosis is very necessary.
Summary of the invention:
The object of the invention provides a kind of tcm small compound prescription for the treatment of osteoporosis and preparation method thereof.
Pharmaceutical composition of the present invention (tcm small compound prescription) is made up of following Chinese medicine:
Herba Epimedii 5-50 weight portion; Rhizoma Drynariae 5-50 weight portion; Fructus Cnidii 5-50 weight portion; Radix Salviae Miltiorrhizae 5-50 weight portion.
The preparation method of this tcm small compound prescription is as described below:
Take by weighing dry medical material by the prescription proportioning, with extracting solvent extraction, the ratio of material and solvent is 1:6～10 times, calorify under the boiling point condition of solvent for use, and each 1～3 hour, extracts three times, filter three extracting solution of merging, concentrated, drying is ground into fine powder.
Dry medical material in the prescription can extract respectively, each 1～3 hour, extract three times, filter to merge three extracting solution, concentrate, drying, be ground into fine powder after, mixing.
The alcohol that the said extracted thing can further use resin concentration, extract to join water on the resin column and 10% is washed impurity to colourless, and the alcohol that continues with 30～75% carries out eluting, and eluent is concentrated, and drying is ground into fine powder.
Extracting solvent can be that concentration is 10～95% ethanol, propanol, methanol or water; Eluting solvent can be 30～75% methanol or ethanol.
Can also add conventional excipient in the tcm small compound prescription of the present invention as required and make any in tablet, capsule, granule, pill and the masticatory.Excipient is one or more in solvent, disintegrating agent, correctives, antiseptic, adhesive, lubricant, diluent, coloring agent, dispersant and the coating solution.
In the medicament composing prescription of tcm small compound prescription of the present invention, Herba Epimedii Xin Ganwen goes into the Liver and kidney warp.Be apt to invigorating the liver and kidney and strengthening bone and muscle, treatment muscles and bones flaccidity is soft, the disease of numb arthralgia pain.Invigorating the liver and kidney and ask pathological changes this, strengthening bone and muscle, stopping numbness pain and get the mark of pathological changes.A large amount of with it, as monarch drug in the side.The arduous temperature of Fructus Cnidii is gone into the Liver and kidney warp.Be the agent of warming and recuperating the kidney-YANG, control the arthralgia chiefly caused by damp pathogen lumbago again.The bitter temperature of Rhizoma Drynariae is gone into the kidney Liver Channel.Be longer than the kidney invigorating bone strengthening, continue and hinder pain relieving, be the key medicine of Shangke bone-knitting.Also main lumbago due to renal deficiency.Two medicine mutual reinforcements between are usefulness, close and invigorating the liver and kidney, and strengthening bone and muscle ends lumbago.Treating both the principal and secondary aspects of a disease is total to principal drug assistance with Cheng Qigong, ministerial drug in the side of being combined into.The Radix Salviae Miltiorrhizae hardship is slightly cold, and goes into the conscience warp.Kind blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia.Now clear and definite, person in middle and old age see person who suffer from deficiency of kidney Yang, and the change that causes the stasis of blood because of void is whenever arranged, and get the Radix Salviae Miltiorrhizae promoting blood circulation and stopping pain, do making supporting movement to cut off enemy of liver and kidney tonifying, so adjuvant drug in the side of being.
All four flavors of full presciption medicine, property is gentle partially, and the invigorating the liver and kidney of advocating becomes this to cure the disease, dual-purpose bone strengthening pain relieving and manage the mark of symptom.Treating both the principal and secondary aspects of a disease, the principal and subordinate takes into account.Liver and kidney must be mended, and then muscles and bones is able to scholar and supports, and the strong muscle of bone is gentle, and all diseases must be recovered.
The present invention is by organic compatibility of four kinds of Chinese medicines, and treating both the principal and secondary aspects of a disease both can pass through the benefiting action slow down aging, reduces bone loss; Can promote bone trabecula to increase again, bone toughness strengthens; Effectively pain relieving, reduction of patient misery, prevention fracture.The present invention is a Chinese medicine preparation, and toxic and side effects is little, and medication is safer, has more superiority than chemicals and biological preparation.
The present invention through the systematic study to tcm small compound prescription, finds that it has an osteoplastic activity of direct promotion osteoblast external under drug activity is followed the tracks of.Pharmacological action is as follows in its body: select the female rats osteoporosis model due to the bilateral removal ovary for use, after giving the tcm small compound prescription extract, the administration group is compared with the model group rat, the bone density of rat obviously increases, ALP is active obviously to be reduced, serum osteocalcin, estradiol level have the raising (P＜0.05) of significance, and the result shows that this pharmaceutical composition can effectively suppress too high bone turnover rate, promote bone formation and bring into play function of resisting osteoporosis.The bone calcium of administration group rat, bone phosphorus content are compared with model group all significantly to be increased, key weight, degrease dry weight and ash heavily have the trend of remarkable increase, the result shows that this pharmaceutical composition can promote the deposition of bone mineral at bone, improve rat bone mineral content and bone density, and can promote building again of bone structure, improve the internal structure of bone, thereby the bearing capacity of osseous tissue is strengthened and the generation of reduction fracture.
Advantage of the present invention is that this tcm small compound prescription can prevent and treat the other diseases of osteoporosis and initiation thereof, thereby a kind of new treatment approach is provided for the patient of osteoporosis.Extracting method of the present invention, science is stable, is applicable to suitability for industrialized production.
The specific embodiment:
Embodiment 1:
Herba Epimedii (100g), Fructus Cnidii (50g), Rhizoma Drynariae (50g), Radix Salviae Miltiorrhizae (50g)
Get above-mentioned medical material respectively, respectively add 8 times of amount 75% ethanol, soak 12h, heating and refluxing extraction 1h is put coldly, filter, respectively Herba Epimedii, Fructus Cnidii, the extracting solution of Rhizoma Drynariae and Radix Salviae Miltiorrhizae.Medicinal residues respectively add 8 times of amount ethanol again, ditto operate secondary, merge three times the gained extracting solution, concentrate, and drying is ground into fine powder, get the ethanol extract of four Chinese medicine material respectively.With the ethanol extract fine powder mixing of four Chinese medicine material, after sieving, adding appropriate amount of starch, lactose powder are made granule, check, packing, every bag of about 5.0g.
Embodiment 2:
Herba Epimedii (100g), Fructus Cnidii (50g), Rhizoma Drynariae (50g), Radix Salviae Miltiorrhizae (50g)
Get above-mentioned medical material, add 8 times of amount 75% ethanol, soak 12h, heating and refluxing extraction 1h is put coldly, filter, extracting solution.Medicinal residues add 8 times of amount ethanol, ditto operate secondary, merge three times the gained extracting solution, concentrate, and drying is ground into fine powder.The said extracted thing is added to the alcohol of water on the resin column and 10% and washes impurity to colourless, and the alcohol that continues with 50% carries out eluting, and eluent is concentrated, and drying is ground into fine powder.After fine powder sieved, add appropriate amount of starch, lactose, Pulvis Talci and granulate, the hard capsule of packing into, every about 0.5g, check is packed.
Claims (7)
1, the pharmaceutical composition of treatment osteoporosis, it is characterized in that: this pharmaceutical composition is to be made by following raw material medicaments: Herba Epimedii 100g; Rhizoma Drynariae 50g; Fructus Cnidii 50g; Radix Salviae Miltiorrhizae 50g.
2, a kind of preparation of drug combination method of treatment osteoporosis as claimed in claim 1, it is characterized in that: its preparation technology is as follows: take by weighing dry medical material by the prescription proportioning, with extracting solvent extraction, the ratio of material and solvent is 1:6～10 times, calorifies under the boiling point condition of solvent for use, each 1～3 hour, extract three times, filter three extracting solution of merging, concentrate, drying is ground into fine powder.
3, the preparation of drug combination method of treatment osteoporosis according to claim 2 is characterized in that: the dry medical material in the prescription can extract respectively, each 1～3 hour, extract three times, filter three extracting solution of merging, concentrate, drying, be ground into fine powder after, mixing.
4, according to the preparation of drug combination method of claim 2 or 3 described treatment osteoporosis, it is characterized in that: the said extracted thing can further be used resin concentration, extract joins the alcohol of water on the resin column and 10% and washes impurity to colourless, the alcohol that continues with 30～75% carries out eluting, eluent is concentrated, drying is ground into fine powder;
5, the preparation of drug combination method of treatment osteoporosis according to claim 2 is characterized in that: extracting solvent is that concentration is 10～95% ethanol.
6, according to the preparation of drug combination method of claim 2 or 3 described treatment osteoporosis, it is characterized in that: the gained fine powder directly or add pharmaceutically acceptable excipient and make any in tablet, capsule, granule, the pill.
7, the preparation of drug combination method of treatment osteoporosis according to claim 6 is characterized in that: described excipient is one or more in disintegrating agent, correctives, antiseptic, adhesive, lubricant, diluent, coloring agent, dispersant and the coating solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100211210A CN100484542C (en) | 2004-02-09 | 2004-02-09 | Chinese medicinal compound recipe for treating osteoporosis and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100211210A CN100484542C (en) | 2004-02-09 | 2004-02-09 | Chinese medicinal compound recipe for treating osteoporosis and its preparing process |
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| CN1557424A CN1557424A (en) | 2004-12-29 |
| CN100484542C true CN100484542C (en) | 2009-05-06 |
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| CNB2004100211210A Expired - Fee Related CN100484542C (en) | 2004-02-09 | 2004-02-09 | Chinese medicinal compound recipe for treating osteoporosis and its preparing process |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332676C (en) * | 2004-10-11 | 2007-08-22 | 江西本草天工科技有限责任公司 | Preparation for enriching calcium, and preparation method |
| CN1994392B (en) * | 2006-01-06 | 2010-06-23 | 刘子响 | Compound drynaria capsule and tablet and preparation method thereof |
| CN101485722B (en) * | 2009-02-13 | 2012-05-30 | 南京师范大学 | Medicament composition containing drynaria and salvia root, and use thereof |
| CN104666394A (en) * | 2014-09-24 | 2015-06-03 | 普正药业股份有限公司 | Eucommia product having health protection efficacy on osteoporosis and preparation method of eucommia product |
| CN107233563A (en) * | 2017-07-10 | 2017-10-10 | 西藏月王藏药科技有限公司 | Tibetan medicinal composition of the pre- preventing bone rarefaction containing highland barley monascus, preparation, using and preparation method thereof |
-
2004
- 2004-02-09 CN CNB2004100211210A patent/CN100484542C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 中药治疗雇主疏松症的临床研究现状. 田丙坤等.陕西中医学院学报，第22卷第4期. 1999 |
| 中药治疗雇主疏松症的临床研究现状. 田丙坤等.陕西中医学院学报，第22卷第4期. 1999 * |
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| CN1557424A (en) | 2004-12-29 |
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