CN102872314A - Drug for treating gout and preparation method for drug - Google Patents

Drug for treating gout and preparation method for drug Download PDF

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CN102872314A
CN102872314A CN2012104166219A CN201210416621A CN102872314A CN 102872314 A CN102872314 A CN 102872314A CN 2012104166219 A CN2012104166219 A CN 2012104166219A CN 201210416621 A CN201210416621 A CN 201210416621A CN 102872314 A CN102872314 A CN 102872314A
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radix
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fructus
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CN102872314B (en
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牛健坤
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牛健坤
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Abstract

The invention discloses a drug for treating gout and a preparation method for the drug. The drug for treating the gout is mainly prepared from the following traditional Chinese medicines in a certain weight ratio: frankincense, liquorice, pawpaw, monkshood, ephedra, fructus forsythia, Red Paeony Root, radix achyranthis bidentatae, Angelica sinensis, rhizoma anemarrhenae, jasmine, radix paeoniae alba, rhizoma alismatis, radix sophorae flavescentis, radix aconiti sinensis and the like. The drug for treating the gout has functions of clearing internal heat due to yin deficiency and hectic fever due to yin deficiency and dispelling wind and removing obstruction in the meridians, is fast in effect when being used for treating the gout, and is low in cost, short in course of treatment and high in cure rate.

Description

A kind of medicine for the treatment of gout and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of gout and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Gout claims again " hyperuricemia ", and the purine metabolism obstacle belongs to arthritis a kind of.Gout is that the metabolism of the material of purine in the human body gets muddled, and the synthetic increase of uric acid or discharge reduce, and cause hyperuricemia, when serum Uric Acid Concentration is too high, uric acid is deposited in joint, cartilage and the kidney with the form of sodium salt, causes to organize foreign body inflammatory reaction, i.e. gout.At present gout treatment mainly be according to clinical symptoms for administration, mainly be to eat colchicine in stage of attack to add analgesic so that fast antiinflammatory, remove painfully, the intermission is eaten the medicine uric acid reducing such as other purine, prevention is outbreak again.Basically, the used Western medicine of gout all has serious side effect at present, and cures the symptoms, not the disease.Take the uric acid resisting Western medicine in the intermission in addition, not only the drug withdrawal bounce-back is very fast, and often causes the outbreak of transitivity gout because the uric acid dissolving is too fast.The most fearful is, has Western medicine for a long time, has been doomed to eat bad the Liver and kidney spleen, and the gout that causes reversing is aggravated outbreak repeatedly.This also is that a lot of ward mates would rather bear the reason that severe pain also be unwilling to have Western medicine.Gout has affected daily study, work and life, brings greatly body and mind misery to patient.Therefore, there is great demand in people to the Chinese medicine of effective treatment gout.
Summary of the invention
The inventor has finally found the medicine of effective treatment gout, thereby has finished the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just provides a kind of composition of medicine that can treat gout.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicine of the present invention selects Olibanum, Radix Glycyrrhizae, Fructus Chaenomelis, Radix Aconiti Lateralis Preparata, Herba Ephedrae, Fructus Forsythiae, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Fructus Gardeniae, the Radix Paeoniae Alba, Rhizoma Alismatis, Radix Sophorae Flavescentis, Radix Aconiti, Cortex Phellodendri, Cortex Moutan, Rhizoma Cimicifugae, Fructus Liquidambaris, Herba Violae, Flos Carthami, Squama Manis, Radix Clematidis, Semen Plantaginis, Lumbricus, Radix Rehmanniae, Herba Asari, Semen Vaccariae and Myrrha to make up, with these drug regimens so that each efficacy of drugs produces synergism, thereby recurrence that can the fast treating gout.Wherein select Olibanum to be because its nature and flavor are arduous, temperature enters the heart, liver, spleen channel, and regulating qi and activating blood is arranged, and analgesic therapy chases after malicious function, controls coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Select Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, detoxifcation, the function of coordinating the actions of various ingredients in a prescription is processed usefulness, controls weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, cardiopalmus , Jing Epilepsy; Give birth to usefulness, control laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.Select Fructus Chaenomelis to be because its nature and flavor are sour, temperature enters liver, spleen channel, and suppressing the hyperactive liver and easing the stomach is arranged, and the function of the Shujin that dries being controlled the convulsion of vomiting and diarrhoea, arthralgia chiefly caused by damp pathogen, beriberi, edema, dysentery.Selecting Radix Aconiti Lateralis Preparata is because of its property acrid-sweet flavor, and heat is poisonous, enter the heart, spleen, kidney channel, have recuperating depleted YANG to mend fire, the function of dispelling cold and removing dampness, control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted contrary, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema, children's's intermittent infantile convulsion, the contracture of anemofrigid-damp arthralgia , Wei lame, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.Select Herba Ephedrae to be because its nature and flavor are arduous, temperature enters lung, urinary bladder channel, and diaphoresis is arranged, and relievings asthma, the function of diuretic, the cold table that cures the wound is real, and fever with chills is lossless, headache is had a stuffy nose, arthralgia, cough and asthma, edema due to wind pathogen edema; dysuria, ailment said due to cold or exposure insensitive impediment, munbness, rubella pruritus.Select Fructus Forsythiae to be because its nature and flavor are bitter, cold enters the heart, liver, gallbladder meridian, and heat clearing away is arranged, detoxifcation, eliminating stagnation, the function of detumescence, control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Select Radix Paeoniae Rubra to be because its nature and flavor are bitter, be slightly cold, return Liver Channel, clearing away heat and cooling blood is arranged, the function of eliminating stasis to stop pain is controlled warm poison and is gone mad, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea , Epilepsy abdominal mass stomachache, injury from falling down, carbuncle skin infection.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, give birth to and use dissipating blood stasis blood, subduing inflammation is controlled gonorrhea, hematuria, amenorrhea , mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury is ripely used invigorating the liver and kidney, and bone and muscle strengthening is controlled waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Selecting Radix Angelicae Sinensis is that temperature enters the heart, liver, spleen channel, and benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation because of the sweet suffering of its nature and flavor, control menoxenia, amenorrhea stomachache , mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, and be heavy after the bloody dysentery, ulcer sores, incised wound, injury from falling down.Select the Rhizoma Anemarrhenae to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Fructus Gardeniae to be because its nature and flavor are bitter, cold, enter the heart, liver, lung, stomach warp, heat clearing away is arranged, pathogenic fire purging, the function of removing heat from blood is controlled the calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea is quenched one's thirst, conjunctival congestion, pharyngalgia is spitted blood, epistaxis, dysentery, hematuria, pathopyretic ulcer is sprained and is swollen and ache.Selecting the Radix Paeoniae Alba is that cold enters liver, spleen channel, and nourishing blood to suppress the hyperactive liver is arranged because of its nature and flavor picric acid, slow middle pain relieving, and yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select Rhizoma Alismatis to be because its nature and flavor are sweet, cold, enter urinary bladder channel, diuretic is arranged, eliminating dampness by diuresis, the function that expels the heat-evil is controlled dysuria, and the edema anus is full, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select Radix Sophorae Flavescentis to be because its nature and flavor are bitter, cold, enter liver, kidney, large intestine, small intestine meridian, heat clearing away is arranged, dampness, the function of parasite killing is controlled toxic-heat and blood stasis, discharging fresh blood stool, jaundice, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, anal fistula, proctoptosis, skin pruritus, erosion of vulva pruritus due to damp pathogen, scrofula is scalded.Select Radix Aconiti, its nature and flavor are hot, and heat is poisonous, enters spleen, the gate of vitality's two warps, and dispelling cold and dampness is arranged, loose ailment said due to cold or exposure, and warming the meridian, the function of pain relieving is controlled anemofrigid-damp arthralgia, severe and migratory arthralgia pain, spasm of the limbs, hemiplegia, wind syndrome of head headache, trusted subordinate's cold type of pain, carbuncle of yin nature toxic swelling.Select Cortex Phellodendri to be because its nature and flavor are bitter, cold, enter lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Select Cortex Moutan to be because its nature and flavor are arduous, cold enters the heart, liver, kidney channel, and heat clearing away is arranged, removing heat from blood, and blood, and the function of repercussive is controlled the pathogenic heat attacking blood system in febrile diseases, sends out speckle , Jing Epilepsy, and tell, be defeated in battle, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, amenorrhea , mass in the abdomen, carbuncle and ulcer is pounced on damage.Selecting Rhizoma Cimicifugae is that cold enters lung, spleen, stomach warp, and yang invigorating is arranged, and delivers rash because of the little hardship of the sweet suffering of its nature and flavor, the function of detoxifcation is controlled seasonal epidemic pathogens epidemic disease labor, the headache cold and heat, and laryngalgia, aphtha scar, macule are not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus tenesmus, carbuncle sore tumefacting virus.Select Fructus Liquidambaris to be because its nature and flavor are bitter flat, current 12 warps have dispelling wind and removing obstruction in the collateral, and the function of promoting urination to remove dampness is harnessed the river swollen, distension, and amenorrhea, breast is few, contracture of the limbs.Select Herba Violae to be because its nature and flavor are bitter, hot, cold, GUIXIN, Liver Channel have heat-clearing and toxic substances removing, and the function of removing heat from blood detumescence is controlled furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.Select Flos Carthami to be because its nature and flavor are hot, temperature enters the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged, and the function of blood stasis removing pain relieving is controlled amenorrhea , mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Squama Manis to be because its nature and flavor are salty, cold enters liver, stomach warp, and the routed carbuncle of detumescence is arranged, and searches wind active, and the function of the stimulating milk secretion of stimulating the menstrual flow is controlled the carbuncle skin ulcer swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, external hemostasis.Select Radix Clematidis to be because its nature and flavor suffering is salty, temperature, poisonous, enter urinary bladder channel, wind-damp dispelling is arranged, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump is controlled gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria , lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select Semen Plantaginis to be because its nature and flavor are sweet, cold, enter kidney, urinary bladder channel, diuretic is arranged, heat clearing away makes eye bright, and the function of eliminating the phlegm is controlled urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, the heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Select Lumbricus to be because its nature and flavor are salty, cold, enter liver, spleen, lung meridian, heat clearing away is arranged, suppressing the hyperactive liver, Zhichuan, the function of collateral dredging, control height fanatical hot-tempered, convulsion with spasms, headache due to pathogenic wind-heat, conjunctival congestion, apoplexy and hemiplegia is panted, sore throat, arthralgia, bleeding from the gum, urinary obstruction, scrofula, mumps, skin infection.Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid is controlled the calentura excessive thirst, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Select Herba Asari to be because its nature and flavor are hot, temperature enters lung, kidney channel, dispel the wind, and cold expelling, row water is opened the function of stealing, and controls air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Select Semen Vaccariae to be because its nature and flavor are bitter flat, enter liver, stomach warp, have promoting the circulation of blood to stimulate the menstrual flow, expedite the emergence of stimulating milk secretion, the function of detumescence sore is controlled women's amenorrhea, galactostasis, and difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.Select Myrrha to be because its nature and flavor are bitter, flat, enter Liver Channel, loose blood blood stasis removing is arranged, the function of subduing swelling and relieving pain is controlled and is fallen damage, incised wound, muscles and bones, all Tong , of trusted subordinate mass in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.
The specific embodiment
The drug dose of component of the present invention also is that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope
Olibanum 10-25 gram Radix Glycyrrhizae 4-12 gram Fructus Chaenomelis 8-18 gram
Radix Aconiti Lateralis Preparata 8-12 gram Herba Ephedrae 2-8 gram Fructus Forsythiae 15-28 gram
Radix Paeoniae Rubra 10-22 gram Radix Achyranthis Bidentatae 8-20 gram Radix Angelicae Sinensis 10-20 gram
Rhizoma Anemarrhenae 10-20 gram Fructus Gardeniae 5-12 gram Radix Paeoniae Alba 5-18 gram
Rhizoma Alismatis 10-25 gram Radix Sophorae Flavescentis 10-22 gram Radix Aconiti 12-22 gram
Cortex Phellodendri 8-20 gram Cortex Moutan 14-22 gram liter fiber crops 4-12 gram
Fructus Liquidambaris 8-18 gram Herba Violae 10-22 gram Flos Carthami 6-12 gram
Squama Manis 10-20 gram Radix Clematidis 10-30 gram Semen Plantaginis 10-20 gram
Lumbricus 10-20 gram Radix Rehmanniae 10-20 gram Herba Asari 8-12 gram
Semen Vaccariae 20-40 gram Myrrha 8-22 gram
Wherein, be preferably
Olibanum 15 gram Radix Glycyrrhizaes 8 gram Fructus Chaenomeliss 12 grams
Radix Aconiti Lateralis Preparata 10 gram Herba Ephedraes 5 gram Fructus Forsythiaes 20 grams
Radix Paeoniae Rubra 15 gram Radix Achyranthis Bidentataes 10 gram Radix Angelicae Sinensis 15 grams
The Rhizoma Anemarrhenae 20 gram Fructus Gardeniaes 10 gram Radix Paeoniae Albas 10 grams
Rhizoma Alismatis 20 gram Radix Sophorae Flavescentiss 15 gram Radix Aconitis 20 grams
Cortex Phellodendri 10 gram Cortex Moutans 20 gram liters fiber crops 8 grams
Fructus Liquidambaris 12 gram Herba Violaes 12 gram Flos Carthamis 8 grams
Squama Manis 15 gram Radix Clematidis 25 gram Semen Plantaginiss 15 grams
Lumbricus 12 gram Radix Rehmanniae 14 gram Herba Asaris 10 grams
Semen Vaccariae 30 gram Myrrhas 12 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Olibanum: choose the sub-impurity of shakeout;
2, Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, dry;
3, Fructus Chaenomelis: clear water is cleaned, and slightly soaks, and moistening is to thoroughly, puts in the food steamer to cook, and takes advantage of fervent sheet, weather exposure, take by the red atropurpureus that turns as degree;
4, Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section is dried;
5, Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after little profit, drying;
6, Fructus Forsythiae: choose clean impurity, stranding is opened, except discarding stalk;
7, Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping is cleaned, runs through, and shave, drying, sieve removes chip;
8, Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting is dried;
9, Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
10, the Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, moistens softly, and section is dried;
11, Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
12, the Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
13, Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is dried;
14, Radix Sophorae Flavescentis: choose clean impurity, remove residual stem, clean earth, be soaked in water, pull out, run through, section is dried;
15, Radix Aconiti: choose decontamination, clean the ash bits, dry;
16, Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding are dried;
17, Cortex Moutan: choose decontamination, remove core, clean, run through, section is dried;
18, Rhizoma Cimicifugae: choose decontamination, slightly bubble is cleaned, and pulls out, runs through, and section is dried;
19, Fructus Liquidambaris: remove impurity, clean, dry;
20, Herba Violae: get crude drug, remove impurity, clean, slightly dry in the air cutting, drying;
21, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
22, Squama Manis: get the Squama Manis sheet of choosing clean, separately size is put sand in addition and is fried in the pot to easily, adds the Squama Manis sheet, fries to heaving when being golden yellow, takes out, and sieve shakeout cools;
23, Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting is dried;
24, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
25, Lumbricus: choose decontamination, water rinses, and in time pulls out, dries cutting;
26, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit is cut sheet, drying, and sieve removes chip;
27, Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;
28, Semen Vaccariae: the clean impurity of winnowing with a dustpan, put in the pot, take out when spending six, seventy percent with the slow fire stir-fry in vain to popping, cool;
29, Myrrha: choose decontamination, break into fragment.
Two, preparation
1, Olibanum, Radix Glycyrrhizae, Fructus Chaenomelis, Radix Aconiti Lateralis Preparata, Herba Ephedrae, Fructus Forsythiae, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Fructus Gardeniae, the Radix Paeoniae Alba, Rhizoma Alismatis, Radix Sophorae Flavescentis, Radix Aconiti, Cortex Phellodendri, Cortex Moutan, Rhizoma Cimicifugae, Fructus Liquidambaris, Herba Violae, Flos Carthami, Squama Manis, Radix Clematidis, Semen Plantaginis, Lumbricus, Radix Rehmanniae, Herba Asari, Semen Vaccariae, the Myrrha with described weight adds 6 times of water gagings, soaked 60 minutes, intense fire decocts boiling 20 minutes, used again slow fire boiling 15 minutes, and filtered and namely get for the first time decoction liquor.
2, the medicinal residues that filter are added 3 times of amounts of water, intense fire boils, and uses slow fire boiling 20 minutes again, filters to get decoction liquor for the second time.
3, twice decoction liquor merged, intense fire boils, and uses slow fire boiling 10 minutes again, namely gets and takes medicinal liquid, will take medicinal liquid and be divided into 4 doses.
Medicine of the present invention has the treatment yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, and the function of dispelling wind and removing obstruction in the collateral is used for the treatment of the gout instant effect, and short treating period does not recur, and cure rate is high.
Below further set forth the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg divides two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, serve on 7 days every day twice, observes the administration reaction every day, and the result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's 150 examples for medical treatment.
2, diagnostic criteria
Gout can be divided into four-stage clinically: the phase I is the metabolic arthritis disease phase, and patient the clinical symptoms of gout do not occur except blood uric acid raises; Second stage is that gout is early stage, and the blood uric acid persistence increases, and causes acute gouty arthritis to break out, and first position often is the halluces of foot, redness and swelling of joints, scorching hot swelling; Phase III is gout mid-term, a toe joint when just beginning to fall ill, feed through to gradually the whole body joints such as finger, toe, wrist, ankle, knee joint, and then soft tissue on every side and sclerotin also suffer in various degree destruction and dysfunction, uric acid crystal constantly deposits, formed at leisure the same " tophus " of calculus, at this moment, normal renal function or show as slight decline; The quadravalence section is late gout, patient's joint deformity and dysfunction are day by day serious, tophus increases, volume increases, easily ulceration flows out white urate crystal, the clinical prompting renal functioies such as edema, oliguria, albuminuria, nocturia increase, hypertension, anemia that occur suffer damage, and renal function obviously goes down.
3, Therapeutic Method
Select above-mentioned medicament, each 1 dose, 10 days is a course for the treatment of, takes continuously 4 courses for the treatment of.Period in a medicine will be noted life, diet wants rule.
4, efficacy assessment standard
Produce effects: clinical symptom disappearance after the treatment, blood uric acid is down to normally, has no recurrence in 1~1.5 year
Take a turn for the better: clinical symptoms is obviously improved, and blood uric acid descends, and the outbreak gap phase obviously prolongs;
Invalid: clinical partial symptoms disappears or without change, does not reach improvement standard person.
5, therapeutic outcome
In above-mentioned treatment, with Drug therapy patient with gout 150 examples of the present invention, produce effects 145 examples as a result, obvious effective rate is 96.67%, 3 examples that take a turn for the better, improvement rate is 2%, invalid 2 examples, total effective rate is 98.67%.

Claims (3)

1. medicine for the treatment of gout, it is characterized in that: it is to be made by the crude drug in the following weight scope:
Olibanum 10-25 gram Radix Glycyrrhizae 4-12 gram Fructus Chaenomelis 8-18 gram
Radix Aconiti Lateralis Preparata 8-12 gram Herba Ephedrae 2-8 gram Fructus Forsythiae 15-28 gram
Radix Paeoniae Rubra 10-22 gram Radix Achyranthis Bidentatae 8-20 gram Radix Angelicae Sinensis 10-20 gram
Rhizoma Anemarrhenae 10-20 gram Fructus Gardeniae 5-12 gram Radix Paeoniae Alba 5-18 gram
Rhizoma Alismatis 10-25 gram Radix Sophorae Flavescentis 10-22 gram Radix Aconiti 12-22 gram
Cortex Phellodendri 8-20 gram Cortex Moutan 14-22 gram liter fiber crops 4-12 gram
Fructus Liquidambaris 8-18 gram Herba Violae 10-22 gram Flos Carthami 6-12 gram
Squama Manis 10-20 gram Radix Clematidis 10-30 gram Semen Plantaginis 10-20 gram
Lumbricus 10-20 gram Radix Rehmanniae 10-20 gram Herba Asari 8-12 gram
Semen Vaccariae 20-40 gram Myrrha 8-22 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Olibanum 15 gram Radix Glycyrrhizaes 8 gram Fructus Chaenomeliss 12 grams
Radix Aconiti Lateralis Preparata 10 gram Herba Ephedraes 5 gram Fructus Forsythiaes 20 grams
Radix Paeoniae Rubra 15 gram Radix Achyranthis Bidentataes 10 gram Radix Angelicae Sinensis 15 grams
The Rhizoma Anemarrhenae 20 gram Fructus Gardeniaes 10 gram Radix Paeoniae Albas 10 grams
Rhizoma Alismatis 20 gram Radix Sophorae Flavescentiss 15 gram Radix Aconitis 20 grams
Cortex Phellodendri 10 gram Cortex Moutans 20 gram liters fiber crops 8 grams
Fructus Liquidambaris 12 gram Herba Violaes 12 gram Flos Carthamis 8 grams
Squama Manis 15 gram Radix Clematidis 25 gram Semen Plantaginiss 15 grams
Lumbricus 12 gram Radix Rehmanniae 14 gram Herba Asaris 10 grams
Semen Vaccariae 30 gram Myrrhas 12 grams.
3. the preparation method of described medicine according to claim 1 and 2, it is characterized in that: it comprises the following steps:
(1) gets the raw materials ready
(1) Olibanum: choose the sub-impurity of shakeout;
(2) Radix Glycyrrhizae: choose decontamination, clean, be soaked in water to eighty per cant thoroughly the time, pull out, run through section, dry;
(3) Fructus Chaenomelis: clear water is cleaned, and slightly soaks, and moistening is to thoroughly, puts in the food steamer to cook, and takes advantage of fervent sheet, weather exposure, take by the red atropurpureus that turns as degree;
(4) Radix Aconiti Lateralis Preparata: be soaked in water, pull out, section is dried;
(5) Herba Ephedrae: choose decontamination, remove most woody stems and undesirable root, wash, cutting after little profit, drying;
(6) Fructus Forsythiae: choose clean impurity, stranding is opened, except discarding stalk;
(7) Radix Paeoniae Rubra: get crude drug, remove impurity, big or small stepping is cleaned, runs through, and shave, drying, sieve removes chip;
(8) Radix Achyranthis Bidentatae: choose decontamination, clean, moisten softly, go reed, cutting is dried;
(9) Radix Angelicae Sinensis: choose decontamination, clean, moistening slightly dries in the air when suitable to inside and outside humidity, and section is dried;
(10) Rhizoma Anemarrhenae: choose clean impurity, water hits to be washed, and pulls out, moistens softly, and section is dried;
(11) Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
(12) Radix Paeoniae Alba: choose decontamination, size separately is soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;
(13) Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water to eighty per cant saturating, pulls out, shines coolly, and moistening is even to inside and outside humidity, and section is dried;
(14) Radix Sophorae Flavescentis: choose clean impurity, remove residual stem, clean earth, be soaked in water, pull out, run through, section is dried;
(15) Radix Aconiti: choose decontamination, clean the ash bits, dry;
(16) Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding are dried;
(17) Cortex Moutan: choose decontamination, remove core, clean, run through, section is dried;
(18) Rhizoma Cimicifugae: choose decontamination, slightly bubble is cleaned, and pulls out, runs through, and section is dried;
(19) Fructus Liquidambaris: remove impurity, clean, dry;
(20) Herba Violae: get crude drug, remove impurity, clean, slightly dry in the air cutting, drying;
(21) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(22) Squama Manis: get the Squama Manis sheet of choosing clean, separately size is put sand in addition and is fried in the pot to easily, adds the Squama Manis sheet, fries to heaving when being golden yellow, takes out, and sieve shakeout cools;
(23) Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting is dried;
(24) Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
(25) Lumbricus: choose decontamination, water rinses, and in time pulls out, dries cutting;
(26) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit is cut sheet, drying, and sieve removes chip;
(27) Herba Asari: Ex-all impurity, water spray profit, in time cutting is dried;
(28) Semen Vaccariae: the clean impurity of winnowing with a dustpan, put in the pot, take out when spending six, seventy percent with the slow fire stir-fry in vain to popping, cool;
(29) Myrrha: choose decontamination, break into fragment;
(2) preparation
(1) Olibanum, Radix Glycyrrhizae, Fructus Chaenomelis, Radix Aconiti Lateralis Preparata, Herba Ephedrae, Fructus Forsythiae, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Fructus Gardeniae, the Radix Paeoniae Alba, Rhizoma Alismatis, Radix Sophorae Flavescentis, Radix Aconiti, Cortex Phellodendri, Cortex Moutan, Rhizoma Cimicifugae, Fructus Liquidambaris, Herba Violae, Flos Carthami, Squama Manis, Radix Clematidis, Semen Plantaginis, Lumbricus, Radix Rehmanniae, Herba Asari, Semen Vaccariae, the Myrrha with described weight adds 6 times of water gagings, soaked 60 minutes, intense fire decocts boiling 20 minutes, used again slow fire boiling 15 minutes, and filtered and namely get for the first time decoction liquor;
(2) medicinal residues that filter are added 3 times of amounts of water, intense fire boils, and uses slow fire boiling 20 minutes again, filters to get decoction liquor for the second time;
(3) twice decoction liquor merged, intense fire boils, and uses slow fire boiling 10 minutes again, namely gets and takes medicinal liquid.
CN201210416621.9A 2012-10-28 2012-10-28 Drug for treating gout and preparation method for drug Expired - Fee Related CN102872314B (en)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103263655A (en) * 2013-06-03 2013-08-28 石欣 Chinese medicine composition for treating gouty arthritis
CN103735671A (en) * 2013-12-27 2014-04-23 南宁市品迪生物工程有限公司 Medicament for treating gout
CN104208307A (en) * 2014-08-18 2014-12-17 赖彧 Chinese patent medicine treating gout
CN104398608A (en) * 2014-12-01 2015-03-11 高德龙 Deer sinew gout healthcare wine
CN105435187A (en) * 2015-12-29 2016-03-30 余勇 Medicine for treating xerosis and preparation method thereof
CN105434952A (en) * 2015-12-29 2016-03-30 余勇 Medicine for treating scarlatina and preparation method thereof

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CN1401346A (en) * 2001-08-23 2003-03-12 邢良国 Numbness- and pain-eliminating capsule and preparing method thereof
CN1457820A (en) * 2002-05-14 2003-11-26 常顶峰 Pill for eliminating stagnation and pains
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103263655A (en) * 2013-06-03 2013-08-28 石欣 Chinese medicine composition for treating gouty arthritis
CN103735671A (en) * 2013-12-27 2014-04-23 南宁市品迪生物工程有限公司 Medicament for treating gout
CN103735671B (en) * 2013-12-27 2016-01-27 南宁市品迪生物工程有限公司 A kind of medicine for the treatment of gout
CN104208307A (en) * 2014-08-18 2014-12-17 赖彧 Chinese patent medicine treating gout
CN104398608A (en) * 2014-12-01 2015-03-11 高德龙 Deer sinew gout healthcare wine
CN105435187A (en) * 2015-12-29 2016-03-30 余勇 Medicine for treating xerosis and preparation method thereof
CN105434952A (en) * 2015-12-29 2016-03-30 余勇 Medicine for treating scarlatina and preparation method thereof

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