CN103405708A - Drug for treating chronic enteritis and preparation method thereof - Google Patents

Abstract

The invention discloses a drug for treating chronic enteritis and a preparation method thereof. The drug is mainly prepared from the following crude drugs: radix angelicae, white atractylodes rhizome, radix paeoniae alba, elecampane, fructus amomi, angelica sinensis, astragalus membranaceus, tuckahoe and the like according to a weight ratio. The drug has the functions of regulating qi for strengthening spleen, warming mid-energizer and harmonizing stomach, and moisturizing pathogenic dryness to loosen the bowel, and is used for treating the chronic enteritis.

Description

A kind of medicine for the treatment of chronic enteritis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of chronic enteritis and preparation method thereof, belong to the field of Chinese medicines.

Technical background

The chronic inflammation disease of chronic enteritis general reference intestinal, its cause of disease can be the infected by microbes such as antibacterial, mycete, virus, protozoon, also can be due to the reasons such as allergy, allergy.Clinical manifestation be long-term chronic or repeatedly the outbreak the symptoms such as stomachache, diarrhoea and dyspepsia, severe one can have Mucous Stool or watery stool.Cardinal symptom is intermittent abdominal part dull pain, abdominal distention, diarrhoea, meet cold, the feed greasy or drink after and tired, anxious state of mind causes sx↑.Times of defecation increases, the anus tenesmus, and defecation is not well.Defecate shapeless, the visible Mucous Stool of severe patient is the bloody purulent stool of black even.At present, because Western medicine can't effectively be treated chronic enteritis, and easily recurrence, and a lot of side effect are arranged, therefore, there is very large demand in people to the Chinese medicine of effective treatment chronic enteritis.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and clinical repeatedly test and checking, has finally found the medicine of effective treatment chronic enteritis, thereby has completed the present invention.

Purpose of the present invention just is to provide a kind of composition of medicine that can effectively treat chronic enteritis.

Another object of the present invention just has been to provide the preparation method of this composition of medicine.

Medicine of the present invention selects the Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Aucklandiae, Fructus Amomi, Radix Angelicae Sinensis, the Radix Astragali, Poria, Rhizoma Cyperi, Rhizoma Dioscoreae, Semen Plantaginis, Cortex Fraxini, Cortex Phellodendri, Radix Pseudostellariae, Colla Corii Asini crude drug to combine, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of chronic enteritis.Wherein selecting the Radix Angelicae Dahuricae is that temperature, enter lung, spleen, stomach warp because of its nature and flavor suffering, dispel the wind, and dampness, detumescence, the function of pain relieving, control headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enter spleen, stomach warp, and spleen reinforcing is arranged, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, the asthenia weak breath, deficiency-distension, have loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea uneasiness.Select the Radix Paeoniae Alba to be because its nature and flavor picric acid is cool, enter liver, spleen channel, nourishing blood to suppress the hyperactive liver is arranged, slow middle pain relieving, yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Select the Radix Aucklandiae to be because its nature and flavor are arduous, temperature, enter lung, liver, spleen channel, and promoting the circulation of QI to relieve pain are arranged, and the function of warming middle-JIAO for easing the stomach is controlled the invasion by pathogenic cold stagnation of QI, chest and abdomen swelling and pain, and vomiting, have loose bowels, dysentery tenesmus, colic of cold type.Selecting Fructus Amomi is that temperature, enter spleen, stomach warp because of its nature and flavor suffering, has in the circulation of qi promoting tune, and stomach function regulating, the function of being amusing, control the stomachache painful abdominal mass swollen, and the anorexia dyspepsia, choke every vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, benefiting blood and regulating blood circulation is arranged, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty are just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enter lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting, control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process by the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Poria to be because its property slightly sweet flavor is flat, enter the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming, control dysuria edema distending pain, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select Rhizoma Cyperi to be because the hot micro-hard work of its nature and flavor is flat, enter liver, tri-jiao channel, the resolving depression of regulating the flow of vital energy, the function of pain relieving regulating menstruation, treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.Select Rhizoma Dioscoreae to be because its nature and flavor are sweet, flat, enter lung, spleen, kidney channel, spleen invigorating is arranged, tonifying the lung, reinforce the kidney, and the function of benefit essence, control diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, quench one's thirst, seminal emission, leukorrhagia, frequent micturition.Select Semen Plantaginis to be because its nature and flavor are sweet, cold, enter kidney, urinary bladder channel, diuretic is arranged, heat clearing away, improving eyesight, the function of eliminating the phlegm, control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, the heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.Select Cortex Fraxini to be because its nature and flavor hardship is cold, enter liver, gallbladder meridian, the hot dampness that disappears is arranged, antiasthmatic-antitussive, the function of improving eyesight, control bacillary dysentery, enteritis, leucorrhea, chronic tracheitis, conjunctival congestion and swelling pain, epiphora induced by wind, psoriasis.Select Cortex Phellodendri to be because its nature and flavor hardship is cold, enter lung, stomach, kidney channel, nourishing YIN to lower pathogenic fire is arranged, moisturize the function of laxation, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria.Selecting Radix Pseudostellariae is that tepor, enter the heart, spleen, lung three warps, and the function of tonifying the lung, spleen invigorating is arranged, and controls the cough due to deficiency of the lung because of its nature and flavor sweetness and bitterness, insufficiency of the spleen lack of appetite, and cardiopalmus order antiperspirant, spirit is tired.Select Colla Corii Asini to be because its nature and flavor are sweet flat, enter lung, liver, kidney channel, nourishing YIN and supplementing blood is arranged, antiabortive function, control blood deficiency, and cough due to consumptive disease, is had blood in stool at haematemesis, epistaxis, menoxenia, and metrorrhagia, control leakage.

The specific embodiment

The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope

Radix Angelicae Dahuricae 8-15 gram Rhizoma Atractylodis Macrocephalae 8-15 gram Radix Paeoniae Alba 8-15 gram

Radix Aucklandiae 10-20 gram Fructus Amomi 10-20 gram Radix Angelicae Sinensis 8-15 gram

Radix Astragali 10-20 gram Poria 8-15 gram Rhizoma Cyperi 8-12 gram

Rhizoma Dioscoreae 8-15 gram Semen Plantaginis 8-15 gram Cortex Fraxini 8-12 gram

Cortex Phellodendri 8-15 gram Radix Pseudostellariae 8-15 gram Colla Corii Asini 10-15 gram

Preferable amount is

The Radix Angelicae Dahuricae 10 gram Rhizoma Atractylodis Macrocephalae 10 gram Radix Paeoniae Alba 10 grams

The Radix Aucklandiae 15 gram Fructus Amomi 15 gram Radix Angelicae Sinensis 10 grams

The Radix Astragali 15 gram Poria 10 gram Rhizoma Cyperi 10 grams

Rhizoma Dioscoreae 10 gram Semen Plantaginis 10 gram Cortex Fraxini 10 grams

Cortex Phellodendri 10 gram Radix Pseudostellariae 10 gram Colla Corii Asini 12 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

2, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dry;

3, the Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

4, the Radix Aucklandiae: crude drug in whole is put in clear water and cleaned, pull out, moistening 12-24 hour makes soft, and section, dry;

5, Fructus Amomi: choose decontamination and shell, smash to pieces;

6, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;

7, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

8, Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

9, Rhizoma Cyperi: choose decontamination, be ground into particle, winnow with a dustpan fine, soft fur and smalls;

10, Rhizoma Dioscoreae: choose clean impurity, be soaked in water softening to the Rhizoma Dioscoreae central part, pull out slightly and dry in the air, section is dried or is dried;

11, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;

12, Cortex Fraxini: choose decontamination, clean, run through rear stripping and slicing or cutting, dry;

13, Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;

14, Radix Pseudostellariae: extract fibrous root, dry;

15, Colla Corii Asini: smash use to pieces.

Two, preparation

The Radix Angelicae Dahuricae of described weight, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Aucklandiae, Fructus Amomi, Radix Angelicae Sinensis, the Radix Astragali, Poria, Rhizoma Cyperi, Rhizoma Dioscoreae, Semen Plantaginis, Cortex Fraxini, Cortex Phellodendri, Radix Pseudostellariae, Colla Corii Asini crude drug are put into to the container of boiling medicine, add 8 times of amounts of water, soaked 120 minutes, decoct with high heat boiling 30 minutes, used again slow fire boiling 30 minutes, filter and get final product, medicinal liquid is divided into to 4 doses and takes.

Medicine of the present invention has regulating qi-flowing for strengthening spleen, promoting the circulation of QI to relieve pain, and warming middle-JIAO for easing the stomach, the effect of moisturizing laxation, treatment chronic enteritis instant effect, short treating period, do not recur.

Below by test example, further set forth the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get 40 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, and 20 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, every day 2 times, serve on 7 days, observes the administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation material of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's 160 examples for medical treatment, its male patient's 90 examples, female patient 70 examples.

2, diagnostic criteria

(1) symptom of digestive tract: often presenting discontinuity abdominal part dull pain, abdominal distention, stomachache, diarrhoea is the primary disease main manifestations.Meet the thing cold, that oil-feed is greasy or meet anxious state of mind or tired rear outstanding work.Times of defecation increases, and goes several times day or tens of remaining time, and the anus tenesmus, defecate not well.During the chronic enteritis acute attack, visible high heat, abdominal colic, nausea and vomiting, stool are urgently as water or the sticky hemafecia that freezes.

(2) General Symptoms: be chronic consumption symptom, the lustreless complexion lassitude, deficiency of QI with disinclination to talk, limbs fatigue, the happiness temperature is afraid of cold.As at acute inflammation stage, except heating, visible dehydration, acidosis or the hemorrhage performance of suffering a shock.

(3) sign aspect: long-term abdominal discomfort or few abdominal part have a dull ache, and the visible abdominal part of having a medical check-up, umbilicus week or few abdominal part are main, and mild tenderness, bowel sound hyperaction, proctoptosis are arranged.

3, Therapeutic Method

Select above-mentioned medicament, take to the patient, each serving with 1 dose, every day early, respectively take 1 evening, and 7 days is a course for the treatment of, takes continuously 6 courses for the treatment of.

4, efficacy assessment standard

Produce effects: transference cure, body constitution recover normal, observe 1 year without the recidivist;

Take a turn for the better: symptom is clearly better, and symptom fades away;

Invalid: as not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy patients having chronic intestinal inflammation 160 examples of the present invention, produce effects 150 examples as a result, obvious effective rate is 93.75%, 8 examples that take a turn for the better, improvement rate is 5%, invalid 2 examples, total effective rate is 98.75%.

Claims (3)

1. medicine for the treatment of chronic enteritis, it is characterized in that: it is to be made by the crude drug in following weight range:

Radix Angelicae Dahuricae 8-15 gram Rhizoma Atractylodis Macrocephalae 8-15 gram Radix Paeoniae Alba 8-15 gram

Radix Aucklandiae 10-20 gram Fructus Amomi 10-20 gram Radix Angelicae Sinensis 8-15 gram

Radix Astragali 10-20 gram Poria 8-15 gram Rhizoma Cyperi 8-12 gram

Rhizoma Dioscoreae 8-15 gram Semen Plantaginis 8-15 gram Cortex Fraxini 8-12 gram

Cortex Phellodendri 8-15 gram Radix Pseudostellariae 8-15 gram Colla Corii Asini 10-15 gram.

2. external used medicine according to claim 1, wherein the consumption of each crude drug is:

The Radix Angelicae Dahuricae 10 gram Rhizoma Atractylodis Macrocephalae 10 gram Radix Paeoniae Alba 10 grams

The Radix Aucklandiae 15 gram Fructus Amomi 15 gram Radix Angelicae Sinensis 10 grams

The Radix Astragali 15 gram Poria 10 gram Rhizoma Cyperi 10 grams

Rhizoma Dioscoreae 10 gram Semen Plantaginis 10 gram Cortex Fraxini 10 grams

Cortex Phellodendri 10 gram Radix Pseudostellariae 10 gram Colla Corii Asini 12 grams.

3. according to the preparation method of claim 1 or 2 described medicine, it comprises the following steps:

(1) get the raw materials ready

(1) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

(2) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dry;

(3) Radix Paeoniae Alba: choose decontamination, size separately, be soaked in water to eighty per cant saturating, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, section, drying;

(4) Radix Aucklandiae: crude drug in whole is put in clear water and cleaned, pull out, moistening 12-24 hour makes soft, and section, dry;

(5) Fructus Amomi: choose decontamination and shell, smash to pieces;

(6) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dry in the air when suitable to inside and outside humidity, and section is dried;

(7) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;

(8) Poria: be soaked in water, clean and to pull out, vexed after, cut into slices, dry;

(9) Rhizoma Cyperi: choose decontamination, be ground into particle, winnow with a dustpan fine, soft fur and smalls;

(10) Rhizoma Dioscoreae: choose clean impurity, be soaked in water softening to the Rhizoma Dioscoreae central part, pull out slightly and dry in the air, section is dried or is dried;

(11) Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;

(12) Cortex Fraxini: choose decontamination, clean, run through rear stripping and slicing or cutting, dry;

(13) Cortex Phellodendri: choose decontamination, wash, pull out, run through, section or shredding, dry;

(14) Radix Pseudostellariae: extract fibrous root, dry;

(15) Colla Corii Asini: smash use to pieces;

(2) preparation

The Radix Angelicae Dahuricae of described weight, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, the Radix Aucklandiae, Fructus Amomi, Radix Angelicae Sinensis, the Radix Astragali, Poria, Rhizoma Cyperi, Rhizoma Dioscoreae, Semen Plantaginis, Cortex Fraxini, Cortex Phellodendri, Radix Pseudostellariae, Colla Corii Asini crude drug are put into to the container of boiling medicine, add 8 times of amounts of water, soaked 120 minutes, decoct with high heat boiling 30 minutes, used again slow fire boiling 30 minutes, filter and get final product, medicinal liquid is divided into to 4 doses and takes.