CN105012396A - Liniment for treating leucoderma and preparing method - Google Patents
Liniment for treating leucoderma and preparing method Download PDFInfo
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- CN105012396A CN105012396A CN201510485552.0A CN201510485552A CN105012396A CN 105012396 A CN105012396 A CN 105012396A CN 201510485552 A CN201510485552 A CN 201510485552A CN 105012396 A CN105012396 A CN 105012396A
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Abstract
The invention discloses liniment for treating leucoderma and a preparing method. The liniment mainly comprises, by weight, 9 parts to 15 parts of fineleaf schizonepeta herbs, 8 parts to 12 parts of jasminum elongatum, 6 parts to 11 parts of lichen of parmelia saxitilis, 7 parts to 12 parts of lithargyrum, 9 parts to 14 parts of herba tripterospermi, 8 parts to 15 parts of fir fruits, 10 pars to 14 parts of Chinese mosla herbs, 12 parts to 17 parts of semen cuscutae, 8 parts to 13 parts of siegesbeckia orientalis, 6 parts to 12 parts of cubeba, 9 parts to 16 parts of lithospermum, 7 parts to 14 parts of abrus cantoniensis hances and 10 parts to 15 parts of notopterygium roots. The liniment treats both symptoms and root causes and is safe, free of side effects, remarkable in curative effect, high in cure rate and low in treatment cost, and relapses are not prone to occurrence.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat leukodermic liniment and method for making.
Background technology
Vitiligo is that a kind of common posteriority limit office property or general property skin pigment depigmentation are sick.Melanocyte function due to skin disappears and causes, but mechanism is not clear.The each position of whole body can occur, and is common in and refers to the back of the body, wrist, forearm, face, neck and surrounding genital etc.Recent study thinks relevant with following factor: 1. theory of heredity.Vitiligo can appear in twins and family, illustrates that heredity plays an important role in vitiligo morbidity.Research thinks that vitiligo has incomplete penetrance, gene has multiple pathogenic sites.2. theory of autoimmunity.Vitiligo can merge autoimmune disease, as thyroid disease, diabetes, chronic adrenal hypofunction, pernicious anemia, rheumatic arthritis, malignant melanoma etc.The specific antibody of multiple organ can also be detected, as anti-thyroid antibody, anti-gastric parietal cell antibody, antiadrenal antibody, anti-parathyroid gland antibody, smooth muscle antibody, anti-melanocyte antibody etc. in serum.3. spirit and neuro chemistry theory.Nervous and Mental Factors and leukodermic morbidity closely related, most patient is in onset or skin lesion developmental stage spiritedness wound, hypertonicity, depressed or dejected.White macula place teleneuron has degeneration, also supports neuro chemistry theory.4. melanocyte autoclasia theory.Antibody and T lymphocyte can be produced in patients with vitiligo body, illustrate that immunoreation may cause melanocyte to be destroyed.And the toxicity melanocyte precursor of cell synthesis itself and some cause the chemical substance of skin depigmentation also may selectively destruction to melanocyte.5. trace element deficiency theory.In patients with vitiligo blood and skin, copper or ceruloplasmin concentrations reduce, and cause tyrosinase activity to reduce, thus affect the metabolism of melanocyte.6. other factors.Wound, solar exposure and some photosensitive medicines also can bring out vitiligo.
Leukodermic clinical manifestation: sex no significant difference, each age group all can be fallen ill, but sends out well with teenager.Skin lesion is depigmentation speckle, and be often milky, also can be lightpink, smooth surface is without erythra.White macula boundary is clear, and edge pigment compared with normal skin increases, and in white macula, hair is normal or bleach.Pathological changes is apt to occur in irradiates and damage by friction position by sunlight, and how symmetrical disease damage is.White macula is also often pressed nerve segment distribution and is zonation.Except skin lesion, inside lip, labia, glans penis and foreskin, mucosa is also often got involved.The many no conscious symptons of primary disease, small number of patients is at premorbid or have local, affected part scratchiness simultaneously.Vitiligo often accompanies other autoimmune diseasees, as diabetes, thyroid disease, adrenal insufficiency, scleroderma, atoipc dermatitis, alopecia areata etc.Concrete typing is as follows: 1. topical type.(1) focal type.One place or many places white macula are confined to a region, but the not distribution in sections; (2) one-sided type (segmental pattern).One place or many places white macula are sections distribution, suddenly disappear in midline; (3) mucosa type.Only involve mucosa.2. be dispersed in type.(1) homeliness type.Extensively and be dispersed in the white macula of distribution; (2) facial acra type.Be distributed in face and extremity; (3) mixed type.Segmental pattern, facial acra type and/or homeliness type mixed distribution.3. general hair style.Depigmentation all or almost all.The vitiligo of more than 90% is dispersed in type, and in remaining vitiligo, topical type is more than general hair style.This disease can be divided into perfect form and forme fruste two kinds again according to disease damage place depigmentation situation.
Treatment: 1. Drug therapy.(1) psoralen and derivant thereof.Rear irradiation ultraviolet radiation as oral in methoxsalen.(2) megavitamin.As vitamin B complex, vitamin C, Citrin long-term taking.(3) treatment such as medicine of useful cupric.As oral in 0.5% copper-bath.(4) immunomodulator.Levamisole is oral, lyophilized bacillus calmette-guerin vaccine (BCG) intramuscular injection, oral Bovine Placenta etc.(5) skin irritant local is embrocated.Skin is inflamed reaction, and impel pigment hypertrophy, dust head has 30% psoralea tincture, chlormethine ethanol, phenol (pure carbolic acid), 25% ~ 50% trichloroacetic acid, Mylabris tincture etc.This method is only applicable to small pieces skin lesion, and after being coated with, skin lesion place can occur bulla.(6) corticosteroid hormone.Various corticosteroid hormone is as local package treatments such as propanoic acid beclometasone ointment, halometasone cream, omcilon carbamide ointments.2. operative treatment.Skin lesion stablizes the feasible AUTOEPIDERMIC GRAFTING operation of the patient got nowhere.3. decolouring therapy.Be applicable to skin lesion area large, exceed body surface area person over half, put on the skin outside available 3% ~ 20% hydroquinone list methyl phenyl ethers anisole frost.4. physiotherapy.Adopt narrow ripple ultraviolet, long wave ultraviolet or 308nm excimer laser treatment.
Application publication number CN 103040992 A(application number 201210596515.3) Chinese patent literature disclose one and treat leukodermic external used medicine, be made up of the crude drug of following weight portion, Moschus 10g, Radix Angelicae Dahuricae 25g, Caulis Polygoni Multiflori 35g, Flos Carthami 24g, imperial tail 25g, Cortex Dictamni 55g, overgrown with weeds blue or green 25g, Radix Paeoniae Rubra 18g, Radix Saposhnikoviae 55g, the sub-20g in river, Myrrha 24g, Flos Campsis 18g.Application publication number CN 104083584 A(application number 201410385953.4) Chinese patent literature disclose one and treat leukodermic external application Chinese medicine, be made up of the Chinese crude drug of following weight portion: Herba Fici Simplicissimae 120-160 part, Radix achyranthis asperae (Herba Achyranthis Asperae) 20-40 part, Herba Verbenae 20-40 part, Folium Apocyni Veneti 3-9 part, Herba pterocephali 3-9 part, Folium et Cacumen Rhododendri Mariae 3-9 part, Folium Elaeagni 3-9 part, Flos Mume 3-9 part, Radix Sambuci Chiensis 1-5 part, Radix Inulae 1-5 part, Rhizoma dioscoreae 1-5 part, Radix Ranunculi Ternati 1-3 part, Cortex Syingae Amurensis 1-3 part.Application publication number CN 102266488 A(application number 201110213257.1) Chinese patent literature disclose one and treat leukodermic medicine, it is the medicament be made up of the crude drug of following weight proportioning: Fructus Ligustri Lucidi 100 ~ 150 parts, ecliptae herba 100 ~ 150 parts, Rhizoma Et Radix Notopterygii 40 ~ 80 parts, Fructus Psoraleae 30 ~ 50 parts, Radix Polygoni Multiflori Preparata 30 ~ 60 parts, Semen Sinapis Albae (stir-fry) 20 ~ 40 parts, Radix Notoginseng 80 ~ 120 parts, Rhizoma Chuanxiong 100 ~ 150 parts, Caulis Spatholobi 50 ~ 100 parts, Cortex Moutan 50 ~ 100 parts, Radix Achyranthis Bidentatae 40 ~ 80 parts, Rhizoma Cyperi 40 ~ 80 parts, Cortex Magnoliae Officinalis 40 ~ 80 parts, Ramulus Uncariae Cum Uncis 100 ~ 150 parts, Radix Polygalae 100 ~ 150 parts, Fructus Atriplicis Sibiricae 30 ~ 60 parts, the Radix Angelicae Dahuricae 30 ~ 60 parts, Radix Saposhnikoviae 30 ~ 60 parts, Periostracum Cicadae 50 ~ 100 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 40 ~ 80 parts, Cortex Dictamni 40 ~ 80 parts, Radix Platycodonis 40 ~ 80 parts, Radix Angelicae Pubescentis 40 ~ 80 parts, Caulis Polygoni Multiflori 50 ~ 100 parts, Cortex Acanthopancis 50 ~ 100 parts, Herba Taxilli 50 ~ 100 parts,
Pyritum 10 ~ 20 parts, 30 ~ 60 parts, Radix Glycyrrhizae.
At present, doctor trained in Western medicine is not yet clear and definite to the leukodermic cause of disease, western medical treatment vitiligo mainly uses hormone and immunosuppressant treatment or supplementary melanin, there is certain curative effect at initial stage, but hormone and immunosuppressant can not fundamentally solve leukodermic problem, may " control more random and more random " because immune system is interfered on the contrary, and use this kind of medicine, once drug withdrawal, how long have more than is needed, the state of an illness not only can reappear, and may also can " retaliatory " increase the weight of, and hormone and immunosuppressant also easily cause multiple serious side effect.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide one and treat leukodermic liniment and method for making.Treating both the principal and secondary aspects of a disease of the present invention, not easily recurs, and safely, has no side effect, and evident in efficacy, cure rate is high, and medical expense is low.
Technical scheme of the present invention is:
Treat leukodermic liniment, take off the primary raw material medicine stating weight proportion and be prepared from: Herba Schizonepetae 9-15, Herba Oxalidis strictae 8-12, Parmelia saxatilis Ach. 6-11, Lithargyrum 7-12, gold line 9-14, China fir tower 8-15, Herba Moslae 10-14, Semen Cuscutae 12-17 ， Herba Siegesbeckiae 8-13, Fructus Litseae 6-12, Radix Arnebiae (Radix Lithospermi) 9-16, Herba Abri 7-14, Rhizoma Et Radix Notopterygii 10-15.
Treat leukodermic liniment, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Herba Schizonepetae 11-14, Herba Oxalidis strictae 9-11, Parmelia saxatilis Ach. 8-10, Lithargyrum 8-11, gold line 11-13, China fir tower 10-13, Herba Moslae 11-13, Semen Cuscutae 13-15 Herba Siegesbeckiae 9-12, Fructus Litseae 7-10, Radix Arnebiae (Radix Lithospermi) 11-14, Herba Abri 9-12, Rhizoma Et Radix Notopterygii 11-13.
Treat leukodermic liniment, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Herba Schizonepetae 13, Herba Oxalidis strictae 10, Parmelia saxatilis Ach. 9, Lithargyrum 10, gold line 12, China fir tower 11, Herba Moslae 12, Semen Cuscutae 14 Herba Siegesbeckiae 10, Fructus Litseae 9, Radix Arnebiae (Radix Lithospermi) 12, Herba Abri 11, Rhizoma Et Radix Notopterygii 12.
The preparation method of the leukodermic liniment of above-mentioned treatment is:
(1) Lithargyrum is ground into fine powder, crosses No. seven sieves;
(2) get Fructus Litseae, add yellow wine and mix thoroughly, the amount of yellow wine is the 1/6-1/2 of Fructus Litseae weight, and moistening 70-150 minute, puts into the container of ceramic, add a cover, stewing out of water 3.5-6 hour, takes out, dries, be ground into fine powder, crosses No. seven sieves;
(3) Semen Cuscutae is loaded in gauze bag, tighten bag mouth, and put into pot together with all the other 10 taste crude drug except Lithargyrum of Fructus Litseae, add 11 taste crude drug gross weight 7-10 water doubly, soak 40 minutes, intense fire boils fire of larding speech with literary allusions to boiling and boils 48-64 minute, leaches medicinal liquid;
(4) fill in the pot of medicinal residues to step (3) and add 11 taste crude drug gross weight 5.5-8 water doubly, intense fire boils fire of larding speech with literary allusions to boiling and boils 40-56 minute, leaches medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be concentrated into the ointment that relative density is 1.31-1.35, add step (1) and step (2) gained, stir, add vaseline again, the weight of vaseline is 3-5 times of step (1) and step (2) gained gross weight, mixes well into paste and get final product.
Preferably be in step (2), described yellow wine is glutinous rice wine, rice yellow wine or Monas cuspurpureus Went yellow wine.
Preferably be that, in step (2), the amount of yellow wine is the 1/5-1/3 of Fructus Litseae weight.
Preferably be in step (2), moistening 90-130 minute.
Preferably be in step (2), stewing out of water 4-5.5 hour.
Preferably be in step (3), add 11 taste crude drug gross weight 8-9 water doubly.
Preferably be in step (3), intense fire boils fire of larding speech with literary allusions to boiling and boils 52-60 minute.
Preferably be in step (4), fill in the pot of medicinal residues to step (3) and add 11 taste crude drug gross weight 6-7.5 water doubly.
Preferably be in step (4), intense fire boils fire of larding speech with literary allusions to boiling and boils 44-52 minute.
Preferably be, in step (5), to be concentrated into the ointment that relative density is 1.32-1.34.
Preferably be in step (5), the weight of vaseline is 3.4-4.2 times of step (1) and step (2) gained gross weight.
Be more preferably, described in step (2), yellow wine is rice yellow wine.
Be more preferably, in step (2), the amount of yellow wine is 1/4 of Fructus Litseae weight.
Be more preferably, moistening 115 minutes in step (2).
Be more preferably, stewing out of water 5 hours in step (2).
Be more preferably, in step (3), add the water of 11 taste crude drug gross weight 8.5 times.
Be more preferably, intense fire boils fire of larding speech with literary allusions to boiling and boils 57 minutes in step (3).
Be more preferably, in step (4), fill in the pot of medicinal residues the water adding 11 taste crude drug gross weight 6.8 times to step (3).
Be more preferably, intense fire boils fire of larding speech with literary allusions to boiling and boils 48 minutes in step (4).
Be more preferably, in step (5), be concentrated into the ointment that relative density is 1.33.
Be more preferably, in step (5), the weight of vaseline is 3.8 times of step (1) and step (2) gained gross weight.
The leukodermic liniment scientific formula for the treatment of provided by the invention, preparation method is simple, easy to use.In addition, excellent results of the present invention also shows:
1, evident in efficacy, not easily recur;
, have no side effect 2, safely;
3, more rate is high, and medical expense is low;
4, medicine source extensively and price is lower;
5, there is effect of nourishing the liver and kidney, clearing away heat-damp and promoting diuresis, dispelling wind and removing obstruction in the collateral, promoting blood circulation to remove blood stasis, focus nutrition can be strengthened, improve immunity, reach the object for the treatment of both the principal and secondary aspects of a disease.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat leukodermic liniment, the primary raw material medicine getting following weight parts is prepared from (every part is 740g): Herba Schizonepetae 9 parts, Herba Oxalidis strictae 8 parts, Parmelia saxatilis Ach. 6 parts, Lithargyrum 7 parts, gold line 9 parts, 8 parts, China fir tower, Herba Moslae 10 parts, Semen Cuscutae 12 Fen ， Herba Siegesbeckiae 8 parts, Fructus Litseae 6 parts, Radix Arnebiae (Radix Lithospermi) 9 parts, Herba Abri 7 parts, Rhizoma Et Radix Notopterygii 10 parts.
The preparation method of the leukodermic liniment of above-mentioned treatment is:
(1) Lithargyrum is ground into fine powder, crosses No. seven sieves;
(2) get Fructus Litseae, add glutinous rice wine and mix thoroughly, the amount of glutinous rice wine is 1/6 of Fructus Litseae weight, and moistening 70 minutes, puts into the container of ceramic, add a cover, stewing out of water 3.5 hours, takes out, dries, be ground into fine powder, crosses No. seven sieves;
(3) Semen Cuscutae is loaded in gauze bag, tighten bag mouth, and put into pot together with all the other 10 taste crude drug except Lithargyrum of Fructus Litseae, add the water of 11 taste crude drug gross weight 7 times, soak 40 minutes, intense fire boils fire of larding speech with literary allusions to boiling and boils 48 minutes, leaches medicinal liquid;
(4) fill in the pot of medicinal residues the water adding 11 taste crude drug gross weight 5.5 times to step (3), intense fire boils fire of larding speech with literary allusions to boiling and boils 40 minutes, leaches medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be concentrated into the ointment that relative density is 1.31, add step (1) and step (2) gained, stir, add vaseline again, the weight of vaseline is 3 times of step (1) and step (2) gained gross weight, mixes well into paste and get final product.
The using method that gained of the present invention treats leukodermic liniment is: external, by affected part warm water cleaning, dries, and gets gained of the present invention and treats leukodermic liniment uniform application in affected part, be massaged into and absorb completely, every day 2 times.
embodiment 2treat leukodermic liniment, the primary raw material medicine getting following weight parts is prepared from (every part is 740g): Herba Schizonepetae 15 parts, Herba Oxalidis strictae 12 parts, Parmelia saxatilis Ach. 11 parts, Lithargyrum 12 parts, gold line 14 parts, 15 parts, China fir tower, Herba Moslae 14 parts, Semen Cuscutae 17 Fen ， Herba Siegesbeckiae 13 parts, Fructus Litseae 12 parts, Radix Arnebiae (Radix Lithospermi) 16 parts, Herba Abri 14 parts, Rhizoma Et Radix Notopterygii 15 parts.
The preparation method of the leukodermic liniment of above-mentioned treatment is:
(1) Lithargyrum is ground into fine powder, crosses No. seven sieves;
(2) get Fructus Litseae, add glutinous rice wine and mix thoroughly, the amount of glutinous rice wine is 1/2 of Fructus Litseae weight, and moistening 150 minutes, puts into the container of ceramic, add a cover, stewing out of water 6 hours, takes out, dries, be ground into fine powder, crosses No. seven sieves;
(3) Semen Cuscutae is loaded in gauze bag, tighten bag mouth, and put into pot together with all the other 10 taste crude drug except Lithargyrum of Fructus Litseae, add the water of 11 taste crude drug gross weight 10 times, soak 40 minutes, intense fire boils fire of larding speech with literary allusions to boiling and boils 64 minutes, leaches medicinal liquid;
(4) fill in the pot of medicinal residues the water adding 11 taste crude drug gross weight 8 times to step (3), intense fire boils fire of larding speech with literary allusions to boiling and boils 56 minutes, leaches medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be concentrated into the ointment that relative density is 1.35, add step (1) and step (2) gained, stir, add vaseline again, the weight of vaseline is 5 times of step (1) and step (2) gained gross weight, mixes well into paste and get final product.
model case one:yellow XX, female, 25 years old.Main suit: white patch on the face more than 1 year.Before more than 1 year, Finding case white patch on the face, once used the multiple method treatment such as oral medicine, medicine for external use, without taking a turn for the better, then to our hospital.Face lamellar white macula, smooth surface, clear border, depigmentation is serious.Be diagnosed as vitiligo.Use the present embodiment gained to treat leukodermic liniment, external, by affected part warm water cleaning, dry, get gained of the present invention and treat leukodermic liniment uniform application in affected part, be massaged into and absorb completely, every day 2 times.Use 2 months, white macula partial remission.Continue use 1 month, white macula all disappears, and recovers normal skin tone, recovery from illness.Follow up a case by regular visits to vitiligo not recur.
embodiment 3treat leukodermic liniment, the primary raw material medicine getting following weight parts is prepared from (every part is 740g): Herba Schizonepetae 11 parts, Herba Oxalidis strictae 9 parts, Parmelia saxatilis Ach. 8 parts, Lithargyrum 8 parts, gold line 11 parts, 10 parts, China fir tower, Herba Moslae 11 parts, Semen Cuscutae 13 Fen ， Herba Siegesbeckiae 9 parts, Fructus Litseae 7 parts, Radix Arnebiae (Radix Lithospermi) 11 parts, Herba Abri 9 parts, Rhizoma Et Radix Notopterygii 11 parts.
The preparation method of the leukodermic liniment of above-mentioned treatment is:
(1) Lithargyrum is ground into fine powder, crosses No. seven sieves;
(2) get Fructus Litseae, add Monas cuspurpureus Went yellow wine and mix thoroughly, the amount of Monas cuspurpureus Went yellow wine is 1/5 of Fructus Litseae weight, and moistening 90 minutes, puts into the container of ceramic, add a cover, stewing out of water 4 hours, takes out, dries, be ground into fine powder, crosses No. seven sieves;
(3) Semen Cuscutae is loaded in gauze bag, tighten bag mouth, and put into pot together with all the other 10 taste crude drug except Lithargyrum of Fructus Litseae, add the water of 11 taste crude drug gross weight 8 times, soak 40 minutes, intense fire boils fire of larding speech with literary allusions to boiling and boils 52 minutes, leaches medicinal liquid;
(4) fill in the pot of medicinal residues the water adding 11 taste crude drug gross weight 6 times to step (3), intense fire boils fire of larding speech with literary allusions to boiling and boils 44 minutes, leaches medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be concentrated into the ointment that relative density is 1.32, add step (1) and step (2) gained, stir, add vaseline again, the weight of vaseline is 3.4 times of step (1) and step (2) gained gross weight, mixes well into paste and get final product.
model case two:xiao XX, man, 24 years old.Main suit: abdominal part white macula more than 2 years.Before 2 years, there is white macula in patient's abdominal part, rear enlarged areas, and once use multi-medicament treatment, effect does not show.Under the introduction of friend, front to our hospital.Check that patient's abdominal part has not of uniform size, the irregular white macula of form, obscure boundary Chu, is diagnosed as vitiligo.Use the present embodiment gained to treat leukodermic liniment, external, by affected part warm water cleaning, dry, get gained of the present invention and treat leukodermic liniment uniform application in affected part, be massaged into and absorb completely, every day 2 times.Use 1 month, white macula disappears to some extent.Continue use 2 months, white macula all disappears, and recovers normal skin tone, recovery from illness.Follow up a case by regular visits to and do not recur.
embodiment 4treat leukodermic liniment, the primary raw material medicine getting following weight parts is prepared from (every part is 740g): Herba Schizonepetae 14 parts, Herba Oxalidis strictae 11 parts, Parmelia saxatilis Ach. 10 parts, Lithargyrum 11 parts, gold line 13 parts, 13 parts, China fir tower, Herba Moslae 13 parts, Semen Cuscutae 15 Fen ， Herba Siegesbeckiae 12 parts, Fructus Litseae 10 parts, Radix Arnebiae (Radix Lithospermi) 14 parts, Herba Abri 12 parts, Rhizoma Et Radix Notopterygii 13 parts.
The preparation method of the leukodermic liniment of above-mentioned treatment is:
(1) Lithargyrum is ground into fine powder, crosses No. seven sieves;
(2) get Fructus Litseae, add Monas cuspurpureus Went yellow wine and mix thoroughly, the amount of Monas cuspurpureus Went yellow wine is 1/3 of Fructus Litseae weight, and moistening 130 minutes, puts into the container of ceramic, add a cover, stewing out of water 5.5 hours, takes out, dries, be ground into fine powder, crosses No. seven sieves;
(3) Semen Cuscutae is loaded in gauze bag, tighten bag mouth, and put into pot together with all the other 10 taste crude drug except Lithargyrum of Fructus Litseae, add the water of 11 taste crude drug gross weight 9 times, soak 40 minutes, intense fire boils fire of larding speech with literary allusions to boiling and boils 60 minutes, leaches medicinal liquid;
(4) fill in the pot of medicinal residues the water adding 11 taste crude drug gross weight 7.5 times to step (3), intense fire boils fire of larding speech with literary allusions to boiling and boils 52 minutes, leaches medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be concentrated into the ointment that relative density is 1.34, add step (1) and step (2) gained, stir, add vaseline again, the weight of vaseline is 4.2 times of step (1) and step (2) gained gross weight, mixes well into paste and get final product.
model case three:soviet Union XX, female, 30 years old.Main suit: suffer from vitiligo more than 3 years.Before 3 years, place's white macula on Finding case volume, developed afterwards gradually, to stretch expansion to two buccals.Be diagnosed as vitiligo in local hospital inspection, be in hospital undergoing treatment, the state of an illness fails to control.Then to our hospital.Check affected part have the large a slice white macula of palm, form is irregular, white macula smooth surface without scurf, thin fur, normal pulse.Be diagnosed as vitiligo.Use the present embodiment gained to treat leukodermic liniment, external, by affected part warm water cleaning, dry, get gained of the present invention and treat leukodermic liniment uniform application in affected part, be massaged into and absorb completely, every day 2 times.Use 1 month, white macula disappears to some extent.Continue use 2 months, white macula all disappears, recovery from illness.Follow up a case by regular visits to and do not recur.
embodiment 5treat leukodermic liniment, the primary raw material medicine getting following weight parts is prepared from (every part is 740g): Herba Schizonepetae 13 parts, Herba Oxalidis strictae 10 parts, Parmelia saxatilis Ach. 9 parts, Lithargyrum 10 parts, gold line 12 parts, 11 parts, China fir tower, Herba Moslae 12 parts, Semen Cuscutae 14 Fen ， Herba Siegesbeckiae 10 parts, Fructus Litseae 9 parts, Radix Arnebiae (Radix Lithospermi) 12 parts, Herba Abri 11 parts, Rhizoma Et Radix Notopterygii 12 parts.
The preparation method of the leukodermic liniment of above-mentioned treatment is:
(1) Lithargyrum is ground into fine powder, crosses No. seven sieves;
(2) get Fructus Litseae, strengthen cream-coloured wine and mix thoroughly, the amount of rice yellow wine is 1/4 of Fructus Litseae weight, and moistening 115 minutes, puts into the container of ceramic, add a cover, stewing out of water 5 hours, takes out, dries, be ground into fine powder, crosses No. seven sieves;
(3) Semen Cuscutae is loaded in gauze bag, tighten bag mouth, and put into pot together with all the other 10 taste crude drug except Lithargyrum of Fructus Litseae, add the water of 11 taste crude drug gross weight 8.5 times, soak 40 minutes, intense fire boils fire of larding speech with literary allusions to boiling and boils 57 minutes, leaches medicinal liquid;
(4) fill in the pot of medicinal residues the water adding 11 taste crude drug gross weight 6.8 times to step (3), intense fire boils fire of larding speech with literary allusions to boiling and boils 48 minutes, leaches medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be concentrated into the ointment that relative density is 1.33, add step (1) and step (2) gained, stir, add vaseline again, the weight of vaseline is 3.8 times of step (1) and step (2) gained gross weight, mixes well into paste and get final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Schizonepetae: base is former: be stem and leaf and the spica of lip section plant Schizonepeta tenuifolia and many lobed leaf Herba Schizonepetae.The property of medicine: pungent, micro-hardship, micro-wet.Return lung, Liver Channel.Function cures mainly: dispel the wind, and induces sweat, rash, hemostasis.Main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, epistaxis, spits blood, has blood in stool, metrorrhagia, puerperal blood faints.
Herba Oxalidis strictae: base is former: be the branch and leaf of Oleaceae plants Herba Oxalidis strictae.The property of medicine: micro-hardship; Cool in nature.Function cures mainly: heat clearing away, dampness removing, removing toxic substances.Main damp-heat dysentery, stomachache tenesmus, beriberoid pyretic arthralgia, extremity swell and ache, pestilence scrofula, skin ulcer scabies.
Parmelia saxatilis Ach.: base is former: be the thallus of Parmeliaceae phytobezoar prunus mume (sieb.) sieb.et zucc. clothing.The property of medicine: sweet; Property is put down.Return liver, kidney channel.Function cures mainly: invigrating kidney; Improving eyesight; Hemostasis, eliminating damp, detoxifying.Main blurred vision; Lumbocrural pain; Spit blood; Metrorrhagia jaundice, skin ulcer tinea.
Lithargyrum: base is former: for crude oxidation is plumbous.The property of medicine: salty; Pungent; Flat; Poisonous.Return liver, spleen channel.Function cures mainly: dampness; Parasite killing; Convergence; Anticorrosion; Removing toxic substances.Main skin infection festers and does not restrain for a long time; Aphtha; Scabies; Bromhidrosis; Tinea versicolor; (black dry) is dim; Wine Zha nose; Burn and scald; Eczema.
Gold line: base is former: be the herb of gentianaceae plant Hong Kong Tripterospermum affine.The property of medicine: sweet; Pungent; Cold in nature.Function cures mainly: heat-clearing and toxic substances removing; Cough-relieving; Hemostasis.Main cough due to lung-heat; Spitting of blood; Lung abscess; Urine leaching is puckery; Acute mastitis; Furuncle furuncle and phyma; Traumatic hemorrhage.
Shan Ta: base is former: be the cone of Taxodiaceae Cunninghamia plant Lignum seu Ramulus Cunninghamiae Lanceolatae.The property of medicine: pungent, tepor.Function cures mainly: warming the kidney to invigorate YANG, parasite killing detoxify, mind calming, cough-relieving.Cure mainly seminal emission, sexual impotence, vitiligo, acute mastitis, cardiopalmus, cough.
Herba Moslae: base is former: be whole herb with root or the aerial parts of labiate Mosla chinensis Maxim.cv.Jiangxiangru or ofMosla Chinensis Maxim.The property of medicine: pungent, tepor.Attach to the lung and stomach meridians.Function cures mainly: relieving the exterior syndrome by diaphoresis, and middle dampness removing.For the wet flu of body, fever with aversion to cold, has a headache lossless, and stomachache is vomited and diarrhoea, dysuria.
Semen Cuscutae: base is former: be the dry mature seed of convolvulus cuscuta plant.The property of medicine: sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down, externally treating leucoderma.
Herba Siegesbeckiae: base is former: be the aerial parts of composite family Zhi Wu Herba Siegesbeckiae, Herba Siegesbeckiae or siegesbeckia glabrescens Makino.The property of medicine: bitter in the mouth; Pungent; Cold in nature; Mild toxicity.Return liver, kidney channel.Function cures mainly: wind-damp dispelling; The meridian dredging; Heat-clearing and toxic substances removing.Main air pain of dampness syndrome; Stiffness of the muscle and joint; Weakness of the waist and knees; It is unsuccessful partly to penetrate; Hypertension; Malaria; Jaundice; Carbuncle; Sore; Rubella eczema; Insect and animal biting.
Fructus Litseae: base is former: be the fruit of Piperaceae plant Fructus Litseae.The property of medicine: pungent; Temperature.Return spleen, kidney, stomach, urinary bladder channel.Function cures mainly: warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Warming the kidney.Main cold syndrome of the stomach vomiting; Distension and fullness in the abdomen cold type of pain; Increased borborygmus and diarrhea; Colic of cold type is suffered from abdominal pain; Cold-damp dribbling urination is muddy.
Radix Arnebiae (Radix Lithospermi): base is former: be the root of comfrey Radix Arnebiae (Radix Lithospermi), the false Radix Arnebiae (Radix Lithospermi) in Xinjiang-Tibet or Onosma paniculatum.The property of medicine: bitter; Cold.GUIXIN, Liver Channel.Function cures mainly: removing heat from blood, invigorates blood circulation, rash, removing toxic substances.Main macule, measles, spits blood, epistaxis, hematuria, purpura, jaundice, and carbuncle is scalded.
Herba Abri: base is former: be the herb of leguminous plant Guangdong Semen Abri Precatorii.The property of medicine: sweet, bitter; Cool; Nontoxic.GUIXIN, lung, liver, stomach, kidney channel.Function cures mainly: clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main icterohepatitis, stomachache, rheumatic ostalgia, traumatic injury stasis of blood pain, mastalgia.
Rhizoma Et Radix Notopterygii: base is former: be dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii.The property of medicine: pungent, bitter, temperature.Return bladder, kidney channel.Function cures mainly: cold expelling, dispels the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
test examplegained of the present invention treats the clinical practice of leukodermic liniment (embodiment 5): in January, 2008, in December, 2009, screens 306 routine patients with vitiligo in 3 hospitals, man 172 example, female 134 example, age 14-68 year.Be divided into experimental group and matched group at random, often organize 153 examples.Experimental group man 86 example, female 67 example; 15 ~ 66 years old age, average 38.4 years old; The course of disease 3 months-9 years, average 5.2 years.Matched group man 86 example, female 67 example; 14 ~ 68 years old age, average 39.2 years old; The course of disease 4 months-8.5 years, average 5 years.Two groups of patient's physical data compare, and no significant difference (P > 0.05), has comparability.
Therapeutic Method: experimental group uses the present invention to treat leukodermic liniment, using method: by affected part warm water cleaning, dry; getting gained of the present invention and treat leukodermic liniment uniform application in affected part; be massaged into and absorb completely, every day 2 times, 1 month is a course for the treatment of.Matched group uses the Drug therapys such as psoralea tincture, Sublimed Sulfur ammoniated mercury lotion, BAIDIANJING, within 1 month, is a course for the treatment of.After two groups of cases all treat three courses for the treatment of, carry out comparitive study.
Curative effect situation criterion: recovery from illness: white macula all disappears, recovers normal skin tone; Effective: white macula partial remission or reduce, the area recovering normal skin tone accounts for skin lesion area >=50%; Take a turn for the better: white macula partial remission or reduce, the area recovering normal skin tone accounts for skin lesion < 50% and >=10%; Invalid: white macula is unchanged or reduce, recover the area of normal skin tone and account for skin lesion area < 10% or without change.Total effective rate comprises healing, effective and improvement, and result is as shown in table 1.
Table 1: gained of the present invention treats leukodermic liniment compliance test result
efficacy analysis:as can be seen from Table 1, it is 110 people that the experimental group using gained of the present invention to treat leukodermic liniment cures number of cases, effective number of cases is 27 people, improvement number of cases is 13 people, only have 3 people invalid, and the healing number of cases of matched group is only 40 people, effective number of cases is 40 people, improvement number of cases is 32 people, and invalid number of cases is up to 41 people.The total effective rate of experimental group reaches 98.04%, and the total effective rate of matched group is 73.2%.Test shows, experimental group total effective rate is obviously better than matched group, and its curative effect increases substantially, and cure rate significantly promotes, and inefficiency significantly reduces, and two groups of comparing differences have significance.
The present invention is primary raw material medicine with Herba Schizonepetae, Herba Oxalidis strictae, Parmelia saxatilis Ach. and Lithargyrum etc., makes the leukodermic liniment for the treatment of.In side, Herba Schizonepetae is dispeled the wind, and induces sweat, rash, hemostasis.Herba Oxalidis strictae heat clearing away, dampness removing, removing toxic substances.Parmelia saxatilis Ach. invigrating kidney; Improving eyesight; Hemostasis, eliminating damp, detoxifying.Lithargyrum dampness; Parasite killing; Convergence; Anticorrosion; Removing toxic substances.Gold line heat-clearing and toxic substances removing; Cough-relieving; Hemostasis.China fir tower warming the kidney to invigorate YANG, parasite killing detoxify, mind calming, cough-relieving.Herba Moslae relieving the exterior syndrome by diaphoresis, and middle dampness removing.Semen Cuscutae nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.Herba Siegesbeckiae wind-damp dispelling; The meridian dredging; Heat-clearing and toxic substances removing.Fructus Litseae warming spleen and stomach for dispelling cold; Promoting the circulation of QI to relieve pain; Warming the kidney.Radix Arnebiae (Radix Lithospermi) removing heat from blood, invigorates blood circulation, rash, removing toxic substances.Herba Abri clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Rhizoma Et Radix Notopterygii cold expelling, dispels the wind, dehumidifying, pain relieving.Many medicines share, and mutually coordinate, play effect of nourishing the liver and kidney, clearing away heat-damp and promoting diuresis, dispelling wind and removing obstruction in the collateral, promoting blood circulation to remove blood stasis altogether, can strengthen focus nutrition, improve immunity, reach the object for the treatment of both the principal and secondary aspects of a disease.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat leukodermic liniment, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Herba Schizonepetae 9-15, Herba Oxalidis strictae 8-12, Parmelia saxatilis Ach. 6-11, Lithargyrum 7-12, gold line 9-14, China fir tower 8-15, Herba Moslae 10-14, Semen Cuscutae 12-17 Herba Siegesbeckiae 8-13, Fructus Litseae 6-12, Radix Arnebiae (Radix Lithospermi) 9-16, Herba Abri 7-14, Rhizoma Et Radix Notopterygii 10-15.
2. the leukodermic liniment for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Herba Schizonepetae 11-14, Herba Oxalidis strictae 9-11, Parmelia saxatilis Ach. 8-10, Lithargyrum 8-11, gold line 11-13, China fir tower 10-13, Herba Moslae 11-13, Semen Cuscutae 13-15 Herba Siegesbeckiae 9-12, Fructus Litseae 7-10, Radix Arnebiae (Radix Lithospermi) 11-14, Herba Abri 9-12, Rhizoma Et Radix Notopterygii 11-13.
3. the leukodermic liniment for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Herba Schizonepetae 13, Herba Oxalidis strictae 10, Parmelia saxatilis Ach. 9, Lithargyrum 10, gold line 12, China fir tower 11, Herba Moslae 12, Semen Cuscutae 14 Herba Siegesbeckiae 10, Fructus Litseae 9, Radix Arnebiae (Radix Lithospermi) 12, Herba Abri 11, Rhizoma Et Radix Notopterygii 12.
4. the preparation method of the leukodermic liniment for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, step is as follows:
(1) Lithargyrum is ground into fine powder, crosses No. seven sieves;
(2) get Fructus Litseae, add yellow wine and mix thoroughly, the amount of yellow wine is the 1/6-1/2 of Fructus Litseae weight, and moistening 70-150 minute, puts into the container of ceramic, add a cover, stewing out of water 3.5-6 hour, takes out, dries, be ground into fine powder, crosses No. seven sieves;
(3) Semen Cuscutae is loaded in gauze bag, tightens bag mouth, and put into pot together with all the other 10 taste crude drug except Lithargyrum of Fructus Litseae, add 11 taste crude drug gross weight 7-10 water doubly (preferred, add 11 taste crude drug gross weight 8-9 water doubly; Be more preferably, add the water of 11 taste crude drug gross weight 8.5 times), soak 40 minutes, intense fire boils fire of larding speech with literary allusions to boiling and boils 48-64 minute (preferred, intense fire boils fire of larding speech with literary allusions to boiling and boils 52-60 minute; Be more preferably, intense fire boils fire of larding speech with literary allusions to boiling and boils 57 minutes), leach medicinal liquid;
(4) fill in the pot of medicinal residues to step (3) water adding 11 taste crude drug gross weight 5.5-8 times and (preferably, fill in the pot of medicinal residues the water adding 11 taste crude drug gross weight 6-7.5 times to step (3); Be more preferably, fill in the pot of medicinal residues the water adding 11 taste crude drug gross weight 6.8 times to step (3)), intense fire boils fire of larding speech with literary allusions to boiling and boils 40-56 minute (preferred, intense fire boils fire of larding speech with literary allusions to boiling and boils 44-52 minute; Be more preferably, intense fire boils fire of larding speech with literary allusions to boiling and boils 48 minutes), leach medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be concentrated into the ointment that relative density is 1.31-1.35, add step (1) and step (2) gained, stir, add vaseline again, the weight of vaseline is 3-5 times of step (1) and step (2) gained gross weight, mixes well into paste and get final product.
5. the preparation method of the leukodermic liniment for the treatment of as claimed in claim 4, is characterized in that, yellow wine described in step (2) is glutinous rice wine, rice yellow wine or Monas cuspurpureus Went yellow wine (preferred described yellow wine is rice yellow wine).
6. the preparation method of the leukodermic liniment for the treatment of as claimed in claim 4, is characterized in that, in step (2), the amount of yellow wine is the amount of the preferred yellow wine of 1/5-1/3(of Fructus Litseae weight is 1/4 of Fructus Litseae weight).
7. the preparation method of the leukodermic liniment for the treatment of as claimed in claim 4, is characterized in that, in step (2) moistening 90-130 minute (preferred moistening 115 minutes).
8. the preparation method of the leukodermic liniment for the treatment of as claimed in claim 4, is characterized in that, in step (2) stewing out of water 4-5.5 hour (preferred stewing out of water 5 hours).
9. the preparation method of the leukodermic liniment for the treatment of as claimed in claim 4, is characterized in that, be concentrated into the ointment (being preferably concentrated into the ointment that relative density is 1.33) that relative density is 1.32-1.34 in step (5).
10. the preparation method of the leukodermic liniment for the treatment of as claimed in claim 4, it is characterized in that, in step (5), the weight of vaseline is 3.4-4.2 times (weight of preferred vaseline is 3.8 times of step (1) and step (2) gained gross weight) of step (1) and step (2) gained gross weight.
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| CN101244221A (en) * | 2007-02-13 | 2008-08-20 | 汪建国 | Composition for external application and preparation method |
| CN104147496A (en) * | 2014-08-08 | 2014-11-19 | 徐辉 | Drug for treating leucoderma and preparation method thereof |
| CN104740222A (en) * | 2013-12-27 | 2015-07-01 | 孔祥军 | Traditional Chinese medicine for treating leucoderma |
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| CN101244221A (en) * | 2007-02-13 | 2008-08-20 | 汪建国 | Composition for external application and preparation method |
| CN104740222A (en) * | 2013-12-27 | 2015-07-01 | 孔祥军 | Traditional Chinese medicine for treating leucoderma |
| CN104147496A (en) * | 2014-08-08 | 2014-11-19 | 徐辉 | Drug for treating leucoderma and preparation method thereof |
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