CN104940840A - Preparation for treating alopecia totalis and preparation method thereof - Google Patents

Abstract

The invention discloses a preparation for treating alopecia totalis. The preparation for treating the alopecia totalis is prepared by the following main raw materials of, by weight, 9-17 parts of cistanche salsa, 11-18 parts of ziziphora clinopodioides lam, 8-15 parts of Szechwan lovage rhizome, 10-17 parts of fructus ligustri lucidi, 8-12 parts of mulberries, 11-17 parts of honeysuckle, 9-14 parts of the root bark of white mulberry, 10-16 parts of holly seeds, 7-13 parts of siegesbeckia, 10-15 parts of roots of red-rooted salvia, 8-17 parts of Chinese honeylocust leaves, 9-13 parts of vernonia patula, 11-16 parts of turmeric root tubers, 8-13 parts of Indian quassiawood, 10-14 parts of densefruit pittany root-bark, 7-16 parts of oriental sesame flowers and 9-12 parts of membranous milk vetch roots. The preparation for treating the alopecia totalis is refined by the adoption of pure natural herbal traditional Chinese medicine unique prescription and technology based on the summary of experience of former researchers, the preparation for treating the alopecia totalis can achieve the functions of promoting blood circulation to remove blood stasis, dredging venation, improving hair follicle nutrition, stimulating hair follicle growth and promoting fresh hair regeneration, and the effect is remarkable. The medicinal herb resources are easy to obtain, the cost is low, and the load of patients can be relieved.

Description

A kind of preparation for the treatment of alopecia totalis and preparation method thereof

Technical field

The present invention relates to traditional Chinese medicine field.Particularly relate to a kind of preparation for the treatment of alopecia totalis and preparation method thereof.

Background technology

Alopecia totalis refers to that hair all comes off, and not only brings spiritual misery to patient, and affects work and life.The psychology that alopecia totalis causes to patient hit can think and, many patient's lassitude all day whole face woeful expression, have even all day long hide dare not go out at home is shown in people, and physical and mental health is had a strong impact on.

The pathology more complicated of alopecia totalis, ancient times are recorded few, and Tang ancestor sea cloud " though after sending out blood, blood is from gasification actually ", the reason of its alopecia, all belongs to the deficiency of blood, gas, essence.The growth of hair depends on blood, and blood is nutrient delivery to hair, and therefore in the green then hair is also vigorous.Meanwhile, QI and blood homology, mutually can transform between QI and blood, interact.Therefore, for alopecia, the traditional Chinese medical science can go to consider from asthenia of qi and blood, the angle of suffering from a deficiency of the kidney.Motherland's medical science thinks that alopecia totalis mostly is cold and hinders skin, occlusion of the pores of skin, or depressed emotion, and qi depression to blood stasis, makes vein stasis blocking, caused by hair mistake is supported.Say in errors in Medicine Corrected: " alopecia after typhoid fever, epidemic febrile disease, the outer blood stasis of flesh side meat blocks blood network, and painstaking effort can not hair care, and clothes are dealt with; Anosis alopecia is also blood stasis." " anemia is dried and withered hairs then for blood stored in the liver, hair is the sign of blood condition.The kidney being the origin of congenital constitution, the source of essence and blood, its Hua Fa." growth of hair comes off, often can react the prosperity and decline of kidney qi, kidney qi is vigorous, then hair is dense pitch-black glossy.Asthenia of renal qi, then asthenia of essence and blood, cause hair to lack nutrition supply, then hypotrichosis easily comes off or the tarnish that bleaches.Modern medicine thinks that body's immunity disorder is the reason of its morbidity, simultaneously relevant in Neuropsychical facto, vasomotoricity, heredity etc.

Application publication number CN103860947A(application number 201410135389.0) Chinese invention patent document disclose a kind of medicament for the treatment of alopecia totalis and alopecia universalis, be made up of the material of following weight proportioning: Herba Anagallidis Arvensis 10 parts, Folium Rhododendri Mucronati 10 parts, Radix seu herba Heteropogonis Contorti 15 parts, Semen Ciceris Arietini 10 parts, Herba Commelinae Diffusae 10 parts, when medicine 6 parts, Arillus Longan 10 parts, Radix Stephaniae hemandifoliae 10 parts, Ilex purpurea Hassk.[I.chinensis Sims 15 parts, Fructus Averrhoae Carambolae 20 parts, fernleaf hedge bamboo 10 parts, the Radix Pulsatillae 10 parts, Herba Iresines Herbstii 15 parts, Herba Blumeae Lacerae 10 parts, Radix Maesae Japonicae 15 parts, Rabdosia rubescens 30 parts, Herba Glechomae 15 parts, Radix et Rhizoma Iridis Sanguineae 10 parts, Radix seu Herba Pegaeophytonis Scapiflori 3 parts, Herba Polygalae Japonicae 15 parts, Herba suadeae glaucae 6 parts, Rhizoma Imperatae 10 parts, the Fructus Kochiae 10 parts, Diplazium lanceum (Thunb) 15 parts, Folium Sauropi 10 parts, Herba Agrimoniae 5 parts, Herba Euphorbiae Humifusae 10 parts, Cacumen Tamaricis 3 parts, Radix Cynanchi Atrati 5 parts, Caulis Bambusae In Taenia 5 parts, Semen Cassiae 10 parts, 3 parts, Pericarpium Zanthoxyli, Herba Lycopodii 5 parts, Ophicalcitum 5 parts, Herba abutili indici 10 parts, Flos Celosiae Cristatae 6 parts, Celastrus gemmatus Loes. 10 parts and 3 parts, Pericarpium Citri Reticulatae Viride.Application publication number CN 104667230 A(application number 201310638850.X) Chinese invention patent document disclose a kind of Chinese medicine for alopecia, be made up of the raw material of following parts by weight: Conch Meretricis seu Cyclinae 2-6, Umbillcaria esculenta 3-8, Rhizoma Zingiberis Recens 2-8, white bandit 1-5, Radix Angelicae Sinensis 1-5, Fructus Mori 5-10, Radix Paeoniae 10-20, Fructus Ligustri Lucidi 5-10, Radix Aconiti Lateralis Preparata 5-10, Cortex Cinnamomi 4-10, Radix Ginseng 1-5, Flos Carthami 3-7.Application publication number CN 103768375 A(application number 201210416791.7) Chinese invention patent document disclose a kind of medicine of hair growth, be made up of the raw material of following parts by weight: Herba Ecliptae 4-9, Radix Angelicae Sinensis 15-25, Semen Sesami Nigrum 50-75, Flos Carthami 13-20, Poria 11-19, Radix Glycyrrhizae 4-10, Radix Polygoni Multiflori 20-40, Fructus Ligustri Lucidi 25-45, Fructus Lycii 11-20, Radix Ophiopogonis 10-15.

The medicine of the symptoms such as current hair growth, is mostly Western medicine, can bring certain toxic and side effects in patient's use procedure, therapeutic effect is not good, fundamentally can not solve the disease of patient, and drug dependence is larger, long-term taking easily causes body damage, immunity degradation.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide a kind of preparation effectively can treating alopecia totalis, adopts medical material comparatively common in the localities as raw material, with low cost.There is therapeutic effect good, have no side effect, the advantage that treatment cost is low.Another object of the present invention is just to provide the preparation method of the preparation of above-mentioned treatment alopecia totalis.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Treat a preparation for alopecia totalis, be prepared from by the primary raw material of following weight proportion: Herba Cistanches 9-17; Lip Rhizoma et radix valerianae 11-18; Rhizoma Chuanxiong 8-15; Fructus Ligustri Lucidi 10-17; Fructus Mori 8-12; Flos Lonicerae 11-17; Cortex Mori 9-14; Fructus Ilicis Cornutae 10-16; Herba Siegesbeckiae 7-13; Radix Salviae Miltiorrhizae 10-15; Folium Gleditsiae 8-17; Herba Vernoniae Patulae 9-13; Radix Curcumae 11-16; Radix Celastri Angulati 8-13; Cortex Dictamni 10-14; Flos Sesami 7-16; Radix Astragali 9-12.

In preferred scheme, Herba Cistanches 11-15; Lip Rhizoma et radix valerianae 13-16; Rhizoma Chuanxiong 10-13; Fructus Ligustri Lucidi 12-15; Fructus Mori 9-11; Flos Lonicerae 12.5-15.5; Cortex Mori 10.5-12.5; Fructus Ilicis Cornutae 12-14; Herba Siegesbeckiae 9-11; Radix Salviae Miltiorrhizae 11.5-13.5; Folium Gleditsiae 11-14; Herba Vernoniae Patulae 10-12; Radix Curcumae 12-15; Radix Celastri Angulati 9.5-11.5; Cortex Dictamni 11-13; Flos Sesami 9-14; Radix Astragali 10-11.

Be more preferably, Herba Cistanches 13; Lip Rhizoma et radix valerianae 14.5; Rhizoma Chuanxiong 11.5; Fructus Ligustri Lucidi 13.5; Fructus Mori 10; Flos Lonicerae 14; Cortex Mori 11.5; Fructus Ilicis Cornutae 13; Herba Siegesbeckiae 10; Radix Salviae Miltiorrhizae 12.5; Folium Gleditsiae 12.5; Herba Vernoniae Patulae 11; Radix Curcumae 13.5; Radix Celastri Angulati 10.5; Cortex Dictamni 12; Flos Sesami 11.5; The Radix Astragali 10.5.

Treat a preparation for alopecia totalis, be made into pharmaceutically acceptable decoction, preparation method is as follows:

(1) Herba Cistanches is placed in Chinese liquor and soaks 5-8 hour (be preferably placed in Chinese liquor soak 6.5 hours), and take out, brush away surface impurity, break into two with one's hands from center, remove tunica albuginea, turn in steamer, steam to well-done, taking-up is dried, for subsequent use; Fructus Mori are smashed to pieces, are placed in fine sand cloth, and extruding, gets its juice, for subsequent use;

(2) Cortex Mori, Radix Celastri Angulati and Cortex Dictamni are chopped up silk respectively, be placed in parch container, slow fire stir-fries to golden yellow, and taking-up cools, and is ground into fine powder, for subsequent use; Fructus Ilicis Cornutae and Fructus Ligustri Lucidi, in 68-80 DEG C of dry 25-45 minute (being preferable over 74 DEG C of dryings 35 minutes), taking out, grind to form fine powder, mix, sieve for subsequent use with Cortex Mori, Radix Celastri Angulati and Cortex Dictamni powder;

(3) Herba Cistanches after step (1) being processed and lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Flos Lonicerae, Herba Siegesbeckiae, Radix Salviae Miltiorrhizae, Folium Gleditsiae, Herba Vernoniae Patulae, Radix Curcumae, Flos Sesami and the Radix Astragali are together placed in Chinese medicine pan, add cold water soak 2-3 hour the cold water soak of 7 times of medical material amounts (preferably add 2.5 hours) of 5.5-8.5 times of medical material amount, then the clear water (preferably adding the clear water of 2 times of medical material amounts) of 1-3 times of medical material amount is added, intense fire heated and boiled, turn slow fire boiling three times, first time decocts 40-50 minute (preferably first time decocts 45 minutes), second time decocts 24-38 minute (preferably second time decocts 30 minutes), third time decocts 10-20 minute (preferably third time decocts 15 minutes), merge three decocting liquids, filter, filtrate is for subsequent use,

(4) mixed powder after step (2) being processed joins in above-mentioned filtrate, slow fire heating decocts 18-34 minute (preferred slow fire heating decoction 26 minutes), three layers of cotton cloth filter, step (1) gained Fructus Mori liquid is added in filtrate, stirring makes it mix homogeneously, be cooled to room temperature, encapsulation, to obtain final product.

Above-mentioned a kind of preparation method for the treatment of the decoction of alopecia totalis, preferred scheme is, in step (1), the number of degrees of Chinese liquor are 40 °-60 ° (number of degrees of preferred Chinese liquor are 45 °-55 °, and the number of degrees of the Chinese liquor be more preferably are 50 °).

Above-mentioned a kind of preparation method for the treatment of the decoction of alopecia totalis, preferred scheme is, the middle 85-135 mesh sieve excessively of step (2) (preferred 100-120 mesh sieve excessively, mistake 110 mesh sieve be more preferably).

The preparation method of described tablet is:

(1) Fructus Ligustri Lucidi and yellow wine are mixed thoroughly (Fructus Ligustri Lucidi: yellow wine=6:1), vexed 8-12 minute (preferably vexed 10 minutes), take out, put in food steamer, and moderate heat heating is steamed 3-6 hour (preferred moderate heat heating steaming 4.5 hours), takes out dry, grinds for subsequent use; Herba Cistanches brushes away surface impurity, and hands is torn into small pieces, in 45-55 DEG C of dry 2.5-5.5 hour (being preferable over 50 DEG C of dryings 4 hours) to exsiccator, takes out and is ground into fine powder, for subsequent use;

(2) by lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Cortex Mori, Herba Siegesbeckiae, Radix Salviae Miltiorrhizae, Herba Vernoniae Patulae, Radix Curcumae, Radix Celastri Angulati, Cortex Dictamni and the Radix Astragali are placed in pulverizer and are together ground into coarse powder, then be placed in percolator, with the ethanol of 30% and the pure water of 70% for solvent, percolation is carried out according to percolation, when the percolate collected is the 22-26 times of raw material medicated powder amount (preferably when the percolate collected is 24 times of raw material medicated powder amount) stop percolation, filter, reclaim ethanol, being evaporated to 78 DEG C of relative densities is the thick paste of 1.18-1.20, drying gets dry extract powder, cool, porphyrize, for subsequent use,

(3) Fructus Mori, Flos Lonicerae, Fructus Ilicis Cornutae, Folium Gleditsiae and Flos Sesami are placed in marmite, add cold water to powder 2-3cm, slow fire heating decoction twice, each respectively decoction 18-30 minute (preferably each each decoction 24 minutes), filtration, filtrate reduced in volume to 85 DEG C relative density is the thick paste of 1.30-1.33, the dried cream powders such as spraying dry, cooling, porphyrize, for subsequent use;

(4) the raw material medicated powder mixing after being processed step (1)-(3), add amylum pregelatinisatum and magnesium stearate (mixed powder: amylum pregelatinisatum: magnesium stearate=6:0.9:0.45), stir, cross 80 mesh sieves, tabletting, to obtain final product.

Above-mentioned a kind of preparation method for the treatment of the tablet of alopecia totalis, preferred scheme is, in step (2), the mass concentration of ethanol is the mass concentration of the preferred ethanol of 80%-100%(is 85%-95%, and the mass concentration of the ethanol be more preferably is 90%).

The preparation method of described pill is:

(1) Flos Lonicerae and Flos Sesami are cleaned respectively, dry, and are placed in parch container, and slow fire heats, and fry to dusky, taking-up cools, and grinds to the powder, for subsequent use; Fructus Ligustri Lucidi and Fructus Ilicis Cornutae are fully dry, porphyrize powder, for subsequent use;

(2) Herba Cistanches, Herba Siegesbeckiae, Folium Gleditsiae and Herba Vernoniae Patulae are placed in medicine pot, the clear water adding 4-8 times of raw material dose soaks 30-50 minute (clear water preferably adding 6 times of raw material doses soaks 40 minutes under room temperature) under room temperature, then slow fire heating decoction twice, first time decocts 24-40 minute (preferably first time decocts 32 minutes), second time decocts 14-30 minute (preferably second time decocts 22 minutes), merges twice decocting liquid, filters, filtrate reduced in volume is to paste, for subsequent use;

(3) by lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Cortex Mori, Radix Salviae Miltiorrhizae, Radix Curcumae, Radix Celastri Angulati, Cortex Dictamni and the Radix Astragali are placed in Chinese medicament extracting device, the mass concentration adding 4-6 times amount is the ethanol of 50%-80% (mass concentration preferably adding 5 times amount is the ethanol of 65%), heating and refluxing extraction twice, reflux, extract, 36-52 minute first time (preferred reflux, extract, for the first time 45 minutes), second time reflux, extract, 20-34 minute (preferably second time reflux, extract, 27 minutes), merge twice alcohol extract, filter, filtrate reduced in volume to 65 DEG C relative density is the thick paste of 1.22-1.25, for subsequent use,

(4) by step (2) and the mixing of step (3) gained thick paste, add the Fructus Mori smashed to pieces, mix thoroughly, add the raw material medicated powder after step (1) process, mechanical agitation, add simultaneously mass fraction be 9.5% sucrose fine and mass fraction be the microcrystalline Cellulose of 5%, mix homogeneously, make the pill of Semen Firmianae size, to obtain final product.

The preparation method of described thick paste agent is:

(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae grind to form fine powder respectively, for subsequent use; Flos Lonicerae, Folium Gleditsiae and Flos Sesami are placed in traditional Chinese medicine drying device in 55-65 DEG C of dry 32-48 minute (being preferable over 60 DEG C of dryings 40 minutes), take out, are placed in pulverizer and are together ground into fine powder, for subsequent use;

(2) Cortex Mori, Radix Celastri Angulati and Cortex Dictamni are chopped up silk respectively, be placed in parch container, slow fire stir-fries to golden yellow, and taking-up cools, and is ground into fine powder, and the raw material medicated powder after processing with step (1) mixes, and is placed in penetrating bag, for subsequent use;

(3) crude drug except step (1) and (2) is placed in Chinese medicine pan, add clear water and do not have powder 4-5cm, soak under room temperature 1-3 hour (soaking 2 hours under preferred room temperature), then add the penetrating bag of step (2) gained, slow fire heating decoction three times, each respectively decoction 22-36 minute (preferably each each decoction 30 minutes), after decoction terminates, merges three decocting liquids, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.25-1.28, and dry heat sterilization, to obtain final product.

The pharmacological effect of each crude drug is respectively:

Herba Cistanches: base is former: be the fleshy stem of orobanchaceae plant cistanche or Herba Cistanches, fan's Herba Cistanches etc.Chemical analysis: Herba Cistanches contains Alkaloid and knot moral character neutral substance.Fan's Herba Cistanches contains alkaloid.Pharmacological action: Herba Cistanches Diluted Alcohol extractum adds in drinking-water raises young rat, and it is fast that its body weight increases comparatively matched group.Water logging agent, alcohol-water leachate and alcohol leaching liquid are tested in anesthetized animals such as Canis familiaris L., cat and rabbits, prove hypotensive activity.Herba Cistanches has promotion salivation and respiratory paralysis effect to mice, and promote that the composition of salivation is certain organic acid sample material, the composition of respiratory paralysis can ability glycoside.Nature and flavor: sweet acid is salty, temperature.Gui Jing: enter kidney, large intestine channel.Function cures mainly: the kidney invigorating, and benefit essence, moisturizes, laxation.Control impotence in male, infertilitas feminis, leukorrhagia, metrorrhagia, chills and pain of the waist and kness, blood depletion constipation.

Lip Rhizoma et radix valerianae: base is former: Labiatae lip Rhizoma et radix valerianae, is used as medicine with Herb.Chemical analysis: aerial parts is containing flavone: gloomy rhinoceros grass element, obscure flower glycoside, 7-methyl 5,7,4'-trihydroxy-6,8,3'-trimethoxyflavone, chrysin-7-O-rutinoside and caffeic acid, 4-hydroxyl-3,5-dimethoxy p-methyl, oleanolic acid, daflon.Oil is containing australene and pulegone.Nature and flavor: oil is pungent; Cool in nature.Function cures mainly: mind tranquilizing and the heart calming; Diuretic heat clearing away.Main cardiopalmus; Insomnia; Edema; Cold, fever; Conjunctival congestion and swelling pain; Sore swollen toxin.

Rhizoma Chuanxiong: base is former: this product is the dry rhizome of samphire Rhizoma Chuanxiong.Character: this product is irregular nodular pattern fist shape agglomerate.Surface yellowish-brown, coarse shrinkage, have the wheel of most parallel ridges to save, there is the similar round stem trace of depression on top, and downside and wheel joint have most little warty root trace.Matter is solid, not frangibility, section yellow-white or lark, and the loose grease chamber having yellowish-brown, cambium ring is wavy.Nature and flavor: pungent, temperature.Gui Jing: return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.Curing mainly: for menoxenia. amenorrhea dysmenorrhea, mass in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache.Rheumatic arthralgia.

Fructus Ligustri Lucidi: base is former: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.Composition: fruit is containing triterpenes: oleanolic acid, acetyloleanolic acid, ursolic acid, acetyl ursolic acid; Phenolic glycoside class: p-hydroxyphenylethanol, Hydroxytyrosol, nuzhenide, oleuropein, Fructus Ligustri Lucidi fruit glycosides, Fructus Ligustri Lucidi acid, Fructus Ligustri Lucidi thuja acid etc.The property of medicine: sweet, bitter, cold.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.Compatibility and incompatibility of drugs: Deficiency and coldness of spleen and stomach is had loose bowels and the careful clothes of yang deficiency person.

Fructus Mori: base is former: be the fruit ear of moraceae plants Mulberry.Chemical analysis: sugary, acid of mixing, malic acid and vitamin B1, B2, C and carotene.The fatty acid of Fructus Mori oil is primarily of the composition such as stearic acid, oleic acid of linoleic acid and amount.Nature and flavor: sweet, cold.Gui Jing: enter liver, kidney channel.Function cures mainly: tonifying liver, and kidney tonifying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.

Flos Lonicerae: base is former: be the alabastrum of caprifoliaceae plant Radix Ophiopogonis.Chemical analysis: flower is containing luteolin, inositol about 1% and Saponin, tannin etc.Nature and flavor: sweet, cold.Gui Jing: enter lung, stomach warp.Function cures mainly: heat clearing away, removing toxic substances.Control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.

Cortex Mori: base is former: be moraceae plants Radix Mori skin.Chemical analysis: containing flavones ingredient: Sang Su, mulberrochromene, cyclomulberrin, ring dyeing alkene, Morusin, ring Morusin, compound, oxidation dihydro Morusin, Phellinus igniarius (L. ex Fr.) Quel. ketone moracenin, sanggenon.Again containing Mulberry color furan, umbelliferone, scopoletin, the acetylcholine analog composition of Mulberry glucoproteid and tool hypotensive effect.Pharmacological action: 1. diuresis and catharsis effect; 2. the multiple molten coal extract such as effect Cortex Mori decoct and water, ethanol, n-butyl alcohol or ether of pair cardiovascular system, through intravenous injection, duodenal administration or oral, to normal dogs, rabbit, rat or hypertension animal, all there is hypotensive effect in various degree, and relatively more lasting, and with bradycardia.3. the effect dog experiment of pair smooth muscle shows, n-butanol extract 50mg/kg intravenous injection obviously can increase GI tract activity; Water extract is then without this effect.4. pair neural effect: (1) calm and stable effect; (2) anticonvulsant action; (3) analgesic activity; (4) n-butanol extract mouse peritoneal injection of lowering the temperature has cooling effect; (5) antibacterial action 100% decoct has inhibitory action to staphylococcus aureus, Bacillus typhi, shigella flexneri.Also inhibitory action is had to Trichophyton.Nature and flavor: sweet; Pungent; Cold in nature.Gui Jing: lung; Spleen channel.Function cures mainly: eliminating pathogen from the lung for relieving asthma; Inducing diuresis to remove edema.Main lung-heat breathes heavily expectorant; Diseases caused by retention of fluid stops lung; Distension dyspnea with rapid respiration; Edema; Foot gas; Dysuria.

Fructus Ilicis Cornutae: base is former: be the fruit of holly plant Ilex cornuta Lindl..Chemical analysis: in Fructus Ilicis Cornutae fatty oily 9.84%.Man is another containing alkaloid, Saponin, tannin.Nature and flavor: bitter; Puckery; Tepor.Gui Jing: liver; Kidney channel.Function cures mainly: invigorating the liver and kidney; Strong muscle is active; The astringent or styptic treatment for spontaneous sweating part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels.Main not empty low grade fever; Bones and muscles pain; Metrorrhagia; Leukorrhagia; Have loose bowels.

Herba Siegesbeckiae: base is former: be the aerial parts of composite family Zhi Wu Herba Siegesbeckiae, Herba Siegesbeckiae or siegesbeckia glabrescens Makino.Pharmacological action: 1. antiinflammatory action: Xian bitterness alkyd, every day 50mg/kg, po10 days, proves there is antiinflammatory action by albumen Heat probe coagulation and rat swelling of the feet method.2. hypotensive effect and vasorelaxation action.3. on the impact of white mice immunologic function.4. on the thrombotic impact of rabbit.5. on the impact of mice Mesentery microcirculation.6. antibacterial and Antimalarial.Nature and flavor: bitter in the mouth; Pungent; Cold in nature; Mild toxicity.Gui Jing: return liver; Kidney channel.Function cures mainly: wind-damp dispelling; The meridian dredging; Poison is striven in heat clearing away.Main air pain of dampness syndrome; Stiffness of the muscle and joint; Weakness of the waist and knees; It is unsuccessful partly to penetrate; Hypertension; Malaria; Jaundice; Carbuncle; Sore; Rubella eczema; Insect and animal biting.

Radix Salviae Miltiorrhizae: base is former: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Chemical analysis: containing TANSHINONES, iso tanshinone, cryptotanshinone, different cryptotanshinone, methyltanshinone, hydroxyl TANSHINONES etc.Character: this product rhizome is short and thick, top is residual stem foot sometimes.Radical bar, elongated cylindrical, slightly bending, some branches tool must shape radicula.Nature and flavor: bitter, are slightly cold.Gui Jing: GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.Cure mainly: for menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Folium Gleditsiae: base is former: be the leaf of leguminous plant Fructus Gleditsia.Chemical analysis: leaf is containing flavonoid glycoside: luteolin-7-glycoside, Isoquercitrin, vitexin, isovitexin, orientin, isorientin.Nature and flavor: pungent; Temperature.Gui Jing: lung meridian.Function cures mainly: removing toxic substances of dispeling the wind; Hair growth promoting.Main air herpes simplex tinea; Hair not life.

Herba Vernoniae Patulae: base is former: be the herb of feverfew Herba Vernoniae Patulae.Chemical analysis: root is containing flavonoid glycoside, triterpene, plant sterol, volatile oil, aminoacid, organic acid.Nature and flavor: bitter in the mouth; Pungent; Property is put down.Function cures mainly: fresh breeze heat clearing away; Eliminating damp, detoxifying; Dissipating blood stasis for subsidence of swelling.Main cold, fever; Malaria; Close pain; Hypertension; Have loose bowels; Dysentery; Rheumatic arthralgia; Eczema; Herba Urticae Cannabinae is examined; Furuncle; Mastitis; The tuberculosis of cervical lymph nodes; Traumatic injury.

Radix Curcumae: base is former: be the tuber of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary, Rhizoma Curcumae or RADIX CURCUMAE from Sichuan of China.Chemical analysis: Radix Curcumae tuber is containing volatile oil 6.1%, wherein camphene 0.8%, and Camphora 2.5%, sesquiterpene 65.5%, main is curcumene, sesquiterpene alcohols 22% etc.Also containing curcumin 0.3%, demethoxycurcumin, bisdemethoxycurcumin, turmerone and aryl turmerone.Another starch-containing 30-40%, fatty oil 3%, rubber, weld, Eucarvone and phellandrene.Its effective ingredient is p-tolyl-methyl methylol curcumin.Nature and flavor: acrid in the mouth; Bitter; Cold in nature.Gui Jing: the heart; Liver; Gallbladder meridian.Function cures mainly: only invigorate blood circulation can; Promoting QI circulation for relieving depression; Clear away heart-fire removing heat from blood; Depressed liver-energy dispersing and function of gallbladder promoting.The all pains of main breast abdomen side of body rib; Dysmenorrhes; Amenorrhea; Lump in the abdomen lumps; Calentura coma; Demented; Infantile convulsion; Spit blood; Be defeated in battle standby; Stranguria with blood; Sand Stranguria; Jaundice.

Radix Celastri Angulati: base is former: be root or the root bark of Celastraceae plant Celastrus angulatus.Chemical analysis: contain Celastrus angulatus in root and root bark, protein, tannin, cupreol, dulcitol, 1a-nicotinylsalicylic oxygen-2a, 6 β diacetoxy-9 β-furoyl Oxy-1 1-(2-methyl) butyryl acyloxy-4 beta-hydroxy dihydro-β-agarofuran, 1a-cigarette acyloxy-2a, 6 β-diacetoxy-9 β-furoyl Oxy-1 1-isobutyl acyloxy-4 beta-hydroxy dihydro-β-agarofuran, 1a-nicotinylsalicylic oxygen-2a, 6 β, 11-triacetoxyl group-9 β-bran acyloxy-4 beta-hydroxy dioxy-β-agarofuran, 1a-nicotinylsalicylic oxygen-2a, 6 β-diacetoxy-9 β-benzoic acid Oxy-1 1-acetoxyl group-4 beta-hydroxy dihydro-β-agarofuran.Nature and flavor: pungent; Bitter; Cool; Mild toxicity.Gui Jing: lung; Liver; Kidney channel.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation to restore menstrual flow; Removing toxic substances parasite killing.Main air pain of dampness syndrome; Fracture is grieved; Amenorrhea; Skin infection festers; Tinea capitis; Pudendal pruritus.

Cortex Dictamni: base is former: be the root bark of rutaceae shaggy-fruited dittany.Chemical analysis: root is containing dictamine, dictamnolactone, sitosterol, obacunonic acid, trigonelline, choline, Ash skin ketone.Still containing campesterol .beta.-fagarine, γ-.gamma.-fagarine, dasycarpamin.Nature and flavor: bitter salty, cold.Gui Jing: enter spleen, stomach warp.Function cures mainly: dispel the wind, dampness, heat clearing away, removing toxic substances.Control wind heat sore, scabies, itchy skin eruption, rheumatic arthralgia, jaundice.

Flos Sesami: base is former: be the flower of Pedaliaceae plant sesame.Function cures mainly: control alopecia, chilblain.

The Radix Astragali: base is former: this product is the dry root of leguminous plant Radix Astagali or Radix Astragali.Nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cure mainly: weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Scientific formula provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:

1,product of the present invention is on the basis of summing up forefathers' experience, and employing pure natural draft Chinese medicine unique formula and technique are refined and formed, and can play blood circulation promoting and blood stasis dispelling, promotion of blood circulation, improve hair follicle nutrition, hair follicle stimulating grows, promote new effect regenerated, Be very effective.

2,selected materials is all Chinese medicine material, through dialectical compatibility, thus effective effect playing its promotion hair growth promoting, safe and effective, have no side effect;

3,medicine source is easy to get, with low cost, can relieve patient ' s burden.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1treat a preparation for alopecia totalis, be prepared from (60g/ part) by the primary raw material of following weight proportion: Herba Cistanches 9 parts; Lip Rhizoma et radix valerianae 11 parts; Rhizoma Chuanxiong 8 parts; Fructus Ligustri Lucidi 10 parts; 8 parts, Fructus Mori; Flos Lonicerae 11 parts; Cortex Mori 9 parts; Fructus Ilicis Cornutae 10 parts; Herba Siegesbeckiae 7 parts; Radix Salviae Miltiorrhizae 10 parts; Folium Gleditsiae 8 parts; Herba Vernoniae Patulae 9 parts; Radix Curcumae 11 parts; Radix Celastri Angulati 8 parts; Cortex Dictamni 10 parts; Flos Sesami 7 parts; The Radix Astragali 9 parts.

A kind of preparation method for the treatment of the decoction of alopecia totalis is:

(1) Herba Cistanches is placed in 40 ° of Chinese liquor immersions 5 hours, and take out, brush away surface impurity, break into two with one's hands from center, remove tunica albuginea, turn in steamer, steam to well-done, taking-up is dried, for subsequent use; Fructus Mori are smashed to pieces, are placed in fine sand cloth, and extruding, gets its juice, for subsequent use;

(2) Cortex Mori, Radix Celastri Angulati and Cortex Dictamni are chopped up silk respectively, be placed in parch container, slow fire stir-fries to golden yellow, and taking-up cools, and is ground into fine powder, for subsequent use; Fructus Ilicis Cornutae and Fructus Ligustri Lucidi, in 68 DEG C of dryings 25 minutes, take out, grind to form fine powder, mix with Cortex Mori, Radix Celastri Angulati and Cortex Dictamni powder, cross 85 mesh sieves, for subsequent use;

(3) Herba Cistanches after step (1) being processed and lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Flos Lonicerae, Herba Siegesbeckiae, Radix Salviae Miltiorrhizae, Folium Gleditsiae, Herba Vernoniae Patulae, Radix Curcumae, Flos Sesami and the Radix Astragali are together placed in Chinese medicine pan, add the cold water soak 2 hours of 5.5 times of medical material amounts, then add the clear water of 1 times of medical material amount, intense fire heated and boiled, turn slow fire boiling three times, first time decocts 40 minutes, second time decocts 24 minutes, and third time decocts 10 minutes, merges three decocting liquids, filter, filtrate is for subsequent use;

(4) mixed powder after step (2) being processed joins in above-mentioned filtrate, and slow fire heating decoction 18 minutes, three layers of cotton cloth filter, and add step (1) gained Fructus Mori liquid in filtrate, stir and make it mix homogeneously, be cooled to room temperature, and encapsulation, to obtain final product.

The instructions of taking of gained decoction of the present invention is: twice daily, each 150-200mL, warmly takes, 30 days courses for the treatment of.

Model case: old XX, female, 30 years old, the new village people in Henan.Patient carrys out my institute's treatment on October 3rd, 2010.Patient's readme: alopecia is had a surplus for 3 years, and hair all comes off, at various big hospital multi-treatment, in, Western medicine attempted tens kinds, be showed no and be clearly better.Now because the reason of alopecia, feel to feel oneself inferior, be unwilling to go out.Have the attitude of trying afterwards upon somebody's introduction in arms, come my institute and check treatment.Check: patient's hair all comes off, scalp itch, susceptible to lose temper due to restlessness, irritable uneasy, red tongue, yellow and thin fur, wiry and frequent pulse.Lab testing liver function is normal.

Take a kind of decoction for the treatment of alopecia totalis of gained of the present invention, instructions of taking: twice daily, each 150-200mL, warmly to take, 30 days courses for the treatment of.After treating a course for the treatment of, patient's alopecia director makes new advances and sends out, and scalp itch is by it, and the mental status can.After treating three courses for the treatment of, patient's alopecia place all grows new sending out, root of hair and color development the same with normal hair quality.Patient's self-induction is fully recovered.Pay a return visit after half a year, patient's kainogenesis is better long, not alopecia again.

embodiment 2treat a preparation for alopecia totalis, be prepared from (20g/ part) by the primary raw material of following weight proportion: Herba Cistanches 17 parts; Lip Rhizoma et radix valerianae 18 parts; Rhizoma Chuanxiong 15 parts; Fructus Ligustri Lucidi 17 parts; 12 parts, Fructus Mori; Flos Lonicerae 17 parts; Cortex Mori 14 parts; Fructus Ilicis Cornutae 16 parts; Herba Siegesbeckiae 13 parts; Radix Salviae Miltiorrhizae 15 parts; Folium Gleditsiae 17 parts; Herba Vernoniae Patulae 13 parts; Radix Curcumae 16 parts; Radix Celastri Angulati 13 parts; Cortex Dictamni 14 parts; Flos Sesami 16 parts; The Radix Astragali 12 parts.

A kind of preparation method for the treatment of the tablet of alopecia totalis is:

(1) Fructus Ligustri Lucidi and yellow wine are mixed thoroughly (Fructus Ligustri Lucidi: yellow wine=6:1), vexed 10 minutes, take out, put in food steamer, and moderate heat heating steaming 4.5 hours, takes out dry, grind for subsequent use; Herba Cistanches brushes away surface impurity, and hands is torn into small pieces, in 50 DEG C of dryings 4 hours to exsiccator, takes out and is ground into fine powder, for subsequent use;

(2) lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Cortex Mori, Herba Siegesbeckiae, Radix Salviae Miltiorrhizae, Herba Vernoniae Patulae, Radix Curcumae, Radix Celastri Angulati, Cortex Dictamni and the Radix Astragali are placed in pulverizer and are together ground into coarse powder, then be placed in percolator, mass concentration with 30% is the ethanol of 90% and the pure water of 70% is solvent, percolation is carried out according to percolation, percolation is stopped when the percolate collected is 24 times of raw material medicated powder amount, filter, reclaim ethanol, being evaporated to 78 DEG C of relative densities is the thick paste of 1.18-1.20, drying gets dry extract powder, cool, porphyrize, for subsequent use;

(3) Fructus Mori, Flos Lonicerae, Fructus Ilicis Cornutae, Folium Gleditsiae and Flos Sesami are placed in marmite, add cold water to powder 2-3cm, slow fire heating decoction twice, each each decoction 24 minutes, filter, filtrate reduced in volume to 85 DEG C relative density is the thick paste of 1.30-1.33, the dried cream powders such as spraying dry, cooling, porphyrize, for subsequent use;

(4) the raw material medicated powder mixing after being processed step (1)-(3), add amylum pregelatinisatum and magnesium stearate (mixed powder: amylum pregelatinisatum: magnesium stearate=6:0.9:0.45), stir, cross 80 mesh sieves, tabletting, to obtain final product.

The instructions of taking of gained tablet of the present invention is: every day three times, each 4-5 sheet, and warm water takes, 30 days courses for the treatment of.

embodiment 3treat a preparation for alopecia totalis, be prepared from (50g/ part) by the primary raw material of following weight proportion: Herba Cistanches 11 parts; Lip Rhizoma et radix valerianae 13 parts; Rhizoma Chuanxiong 10 parts; Fructus Ligustri Lucidi 12 parts; 9 parts, Fructus Mori; Flos Lonicerae 12.5 parts; Cortex Mori 10.5 parts; Fructus Ilicis Cornutae 12 parts; Herba Siegesbeckiae 9 parts; Radix Salviae Miltiorrhizae 11.5 parts; Folium Gleditsiae 11 parts; Herba Vernoniae Patulae 10 parts; Radix Curcumae 12 parts; Radix Celastri Angulati 9.5 parts; Cortex Dictamni 11 parts; Flos Sesami 9 parts; The Radix Astragali 10 parts.

A kind of preparation method for the treatment of the pill of alopecia totalis is:

(1) Flos Lonicerae and Flos Sesami are cleaned respectively, dry, and are placed in parch container, and slow fire heats, and fry to dusky, taking-up cools, and grinds to the powder, for subsequent use; Fructus Ligustri Lucidi and Fructus Ilicis Cornutae are fully dry, porphyrize powder, for subsequent use;

(2) Herba Cistanches, Herba Siegesbeckiae, Folium Gleditsiae and Herba Vernoniae Patulae are placed in medicine pot, the clear water adding 6 times of raw material doses soaks 40 minutes under room temperature, then slow fire heating decoction twice, first time decocts 32 minutes, second time decocts 22 minutes, merges twice decocting liquid, filters, filtrate reduced in volume is to paste, for subsequent use;

(3) lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Cortex Mori, Radix Salviae Miltiorrhizae, Radix Curcumae, Radix Celastri Angulati, Cortex Dictamni and the Radix Astragali are placed in Chinese medicament extracting device, the mass concentration adding 5 times amount is the ethanol of 65%, heating and refluxing extraction twice, reflux, extract, 45 minutes for the first time, second time reflux, extract, 27 minutes, merges twice alcohol extract, filters, filtrate reduced in volume to 65 DEG C relative density is the thick paste of 1.22-1.25, for subsequent use;

(4) by step (2) and the mixing of step (3) gained thick paste, add the Fructus Mori smashed to pieces, mix thoroughly, add the raw material medicated powder after step (1) process, mechanical agitation, add simultaneously mass fraction be 9.5% sucrose fine and mass fraction be the microcrystalline Cellulose of 5%, mix homogeneously, make the pill of Semen Firmianae size, to obtain final product.

The instructions of taking of gained pill of the present invention is: every day three times, each 8-10 ball, and warm water takes, 30 days courses for the treatment of.

Model case: Zhao XX, man, 45 years old, people from Jining.Patient is to our hospital on April 17th, 2012.Patient's readme: occurred alopecia symptom without obvious inducement before 2 years.Just started to think what operating pressure caused greatly, have a rest after have adjusted a period of time and find still alopecia, root of hair is fragile, slightly will drop greatly hair with hands combing, period once used anticreep shampoo, also once took the treatment of various folk prescription, but did not obtain remarkable result.Just all drop less than 1 year hair.Introduce my institute through friend afterwards and attempt treatment.Check: patient's scalp itch, fat secretion is more prosperous, and face is dispersed in inflamed papules, the difficult peace of sleep, yellow urine, red tongue, yellow and greasy fur, slippery and rapid pulse.Lab testing routine blood test and liver function normal.

Take a kind of pill for the treatment of alopecia totalis of the present embodiment gained, instructions of taking: every day three times, each 8-10 ball, warm water takes, 30 days courses for the treatment of.After treating two courses for the treatment of, patient grows fine fleece and newly sends out, and scalp itch disappears, and fat secretion reduces, and after treating three courses for the treatment of, scalp all grows new sending out, and hair quality is normal, without alopecia symptom, and the conscious basic healing of patient.Drug withdrawal is paid a return visit after half a year, and patient's hair is dense, and alopecia symptom thoroughly disappears without recurrence.

embodiment 4treat a preparation for alopecia totalis, be prepared from (30g/ part) by the primary raw material of following weight proportion: Herba Cistanches 15 parts; Lip Rhizoma et radix valerianae 16 parts; Rhizoma Chuanxiong 13 parts; Fructus Ligustri Lucidi 15 parts; 11 parts, Fructus Mori; Flos Lonicerae 15.5 parts; Cortex Mori 12.5 parts; Fructus Ilicis Cornutae 14 parts; Herba Siegesbeckiae 11 parts; Radix Salviae Miltiorrhizae 13.5 parts; Folium Gleditsiae 14 parts; Herba Vernoniae Patulae 12 parts; Radix Curcumae 15 parts; Radix Celastri Angulati 11.5 parts; Cortex Dictamni 13 parts; Flos Sesami 14 parts; The Radix Astragali 11 parts.

A kind of preparation method for the treatment of the thick paste agent of alopecia totalis is:

(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae grind to form fine powder respectively, for subsequent use; Flos Lonicerae, Folium Gleditsiae and Flos Sesami are placed in traditional Chinese medicine drying device in 60 DEG C of dryings 40 minutes, take out, are placed in pulverizer and are together ground into fine powder, for subsequent use;

(2) Cortex Mori, Radix Celastri Angulati and Cortex Dictamni are chopped up silk respectively, be placed in parch container, slow fire stir-fries to golden yellow, and taking-up cools, and is ground into fine powder, and the raw material medicated powder after processing with step (1) mixes, and is placed in penetrating bag, for subsequent use;

(3) crude drug except step (1) and (2) is placed in Chinese medicine pan, add clear water and do not have powder 4-5cm, soak 2 hours under room temperature, then add the penetrating bag of step (2) gained, slow fire heating decoction three times, each each decoction 30 minutes, decocts after terminating, merges three decocting liquids, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.25-1.28, and dry heat sterilization, to obtain final product.

The instructions of taking of gained thick paste of the present invention agent is: twice daily, and each 3-4 spoon is put in warm water and is taken after mixing with liquid, 30 days courses for the treatment of.

embodiment 5treat a preparation for alopecia totalis, be prepared from (40g/ part) by the primary raw material of following weight proportion: Herba Cistanches 13 parts; Lip Rhizoma et radix valerianae 14.5 parts; Rhizoma Chuanxiong 11.5 parts; Fructus Ligustri Lucidi 13.5 parts; 10 parts, Fructus Mori; Flos Lonicerae 14 parts; Cortex Mori 11.5 parts; Fructus Ilicis Cornutae 13 parts; Herba Siegesbeckiae 10 parts; Radix Salviae Miltiorrhizae 12.5 parts; Folium Gleditsiae 12.5 parts; Herba Vernoniae Patulae 11 parts; Radix Curcumae 13.5 parts; Radix Celastri Angulati 10.5 parts; Cortex Dictamni 12 parts; Flos Sesami 11.5 parts; The Radix Astragali 10.5 parts.

A kind of preparation method for the treatment of the decoction of alopecia totalis is:

(1) Herba Cistanches is placed in 50 ° of Chinese liquor immersions 6.5 hours, and take out, brush away surface impurity, break into two with one's hands from center, remove tunica albuginea, turn in steamer, steam to well-done, taking-up is dried, for subsequent use; Fructus Mori are smashed to pieces, are placed in fine sand cloth, and extruding, gets its juice, for subsequent use;

(2) Cortex Mori, Radix Celastri Angulati and Cortex Dictamni are chopped up silk respectively, be placed in parch container, slow fire stir-fries to golden yellow, and taking-up cools, and is ground into fine powder, for subsequent use; Fructus Ilicis Cornutae and Fructus Ligustri Lucidi take out in 74 DEG C of dryings for 35 minutes, grind to form fine powder, mix with Cortex Mori, Radix Celastri Angulati and Cortex Dictamni powder, cross 110 mesh sieves, for subsequent use;

(3) Herba Cistanches after step (1) being processed and lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Flos Lonicerae, Herba Siegesbeckiae, Radix Salviae Miltiorrhizae, Folium Gleditsiae, Herba Vernoniae Patulae, Radix Curcumae, Flos Sesami and the Radix Astragali are together placed in Chinese medicine pan, add the cold water soak 2.5 hours of 7 times of medical material amounts, then add the clear water of 2 times of medical material amounts, intense fire heated and boiled, turn slow fire boiling three times, first time decocts 45 minutes, second time decocts 30 minutes, and third time decocts 15 minutes, merges three decocting liquids, filter, filtrate is for subsequent use;

(4) mixed powder after step (2) being processed joins in above-mentioned filtrate, and slow fire heating decoction 26 minutes, three layers of cotton cloth filter, and add step (1) gained Fructus Mori liquid in filtrate, stir and make it mix homogeneously, be cooled to room temperature, and encapsulation, to obtain final product.

The instructions of taking of gained decoction of the present invention is: twice daily, each 150-200mL, warmly takes, 30 days courses for the treatment of.

test example:a kind of clinical practice for the treatment of the preparation (embodiment 5) of alopecia totalis of gained of the present invention:

Choose in July, 2009 in JIUYUE ,-2013 and come alopecia totalis patient totally 289 examples of my institute treatment, wherein male patient's totally 210 examples, female patient is totally 79 examples, the age 36-66 year.All patients are divided into experimental group 185 example and matched group 104 example at random.Two groups of patients are through statistical procedures in sex, age, the course of disease, and no statistical significance (P > 0.05), has comparability.Wherein experimental group takes a kind of decoction for the treatment of alopecia totalis of gained of the present invention, instructions of taking: twice daily, each 150-200mL, warmly takes, 30 days courses for the treatment of.Matched group, with under experimental group identical time and environment, uses the product of other hair growth promotings (as YANGXUE SHENGFA JIAONANG, the hair-growth ballet that reinforces the kidney, Six-element phalacrosis prevention and hair generation tincture etc.).Observe three courses for the treatment of of treatment altogether.Curative effect situation criterion: recovery from illness: new sending out all grows, densely distributed, hair thickness, color and luster pain normal hair, alopecia transference cure; Effective: new sending out grows more than 50%, has more fine hair on birds or animals hair thicker hardening; Effective: new sending out grows more than 30%, but poor growth.Invalid: to grow less than 30% without newly sending out to grow or newly send out.Total effective rate=cure rate+obvious effective rate+effective percentage.

Result is as shown in the table:

Table 1

efficacy analysis:as can be seen from Table 1, use a kind of experimental group cure rate for the treatment of the preparation of alopecia totalis of gained of the present invention to be 69.7%, inefficiency is 1.1%.And using the matched group cure rate of other conventional product for improving hair-growing to be only 48.1%, inefficiency is up to 22.1%.Experiment shows that a kind of preparation for the treatment of alopecia totalis of gained of the present invention is compared with other conventional product for improving hair-growing, and its curative effect increases substantially, and cure rate significantly promotes, and inefficiency significantly reduces.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat a preparation for alopecia totalis, it is characterized in that, be prepared from by the primary raw material of following weight proportion: Herba Cistanches 9-17; Lip Rhizoma et radix valerianae 11-18; Rhizoma Chuanxiong 8-15; Fructus Ligustri Lucidi 10-17; Fructus Mori 8-12; Flos Lonicerae 11-17; Cortex Mori 9-14; Fructus Ilicis Cornutae 10-16; Herba Siegesbeckiae 7-13; Radix Salviae Miltiorrhizae 10-15; Folium Gleditsiae 8-17; Herba Vernoniae Patulae 9-13; Radix Curcumae 11-16; Radix Celastri Angulati 8-13; Cortex Dictamni 10-14; Flos Sesami 7-16; Radix Astragali 9-12.

2. a kind of preparation for the treatment of alopecia totalis as claimed in claim 1, it is characterized in that, the primary raw material getting following weight proportion is prepared from: Herba Cistanches 11-15; Lip Rhizoma et radix valerianae 13-16; Rhizoma Chuanxiong 10-13; Fructus Ligustri Lucidi 12-15; Fructus Mori 9-11; Flos Lonicerae 12.5-15.5; Cortex Mori 10.5-12.5; Fructus Ilicis Cornutae 12-14; Herba Siegesbeckiae 9-11; Radix Salviae Miltiorrhizae 11.5-13.5; Folium Gleditsiae 11-14; Herba Vernoniae Patulae 10-12; Radix Curcumae 12-15; Radix Celastri Angulati 9.5-11.5; Cortex Dictamni 11-13; Flos Sesami 9-14; Radix Astragali 10-11.

3. a kind of preparation for the treatment of alopecia totalis as claimed in claim 1, it is characterized in that, the primary raw material getting following weight proportion is prepared from: Herba Cistanches 13; Lip Rhizoma et radix valerianae 14.5; Rhizoma Chuanxiong 11.5; Fructus Ligustri Lucidi 13.5; Fructus Mori 10; Flos Lonicerae 14; Cortex Mori 11.5; Fructus Ilicis Cornutae 13; Herba Siegesbeckiae 10; Radix Salviae Miltiorrhizae 12.5; Folium Gleditsiae 12.5; Herba Vernoniae Patulae 11; Radix Curcumae 13.5; Radix Celastri Angulati 10.5; Cortex Dictamni 12; Flos Sesami 11.5; The Radix Astragali 10.5.

4. a kind of preparation for the treatment of alopecia totalis as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:

(1) Herba Cistanches is placed in Chinese liquor and soaks 5-8 hour (be preferably placed in Chinese liquor soak 6.5 hours), and take out, brush away surface impurity, break into two with one's hands from center, remove tunica albuginea, turn in steamer, steam to well-done, taking-up is dried, for subsequent use; Fructus Mori are smashed to pieces, are placed in fine sand cloth, and extruding, gets its juice, for subsequent use;

(2) Cortex Mori, Radix Celastri Angulati and Cortex Dictamni are chopped up silk respectively, be placed in parch container, slow fire stir-fries to golden yellow, and taking-up cools, and is ground into fine powder, for subsequent use; Fructus Ilicis Cornutae and Fructus Ligustri Lucidi, in 68-80 DEG C of dry 25-45 minute (being preferable over 74 DEG C of dryings 35 minutes), taking out, grind to form fine powder, mix, sieve for subsequent use with Cortex Mori, Radix Celastri Angulati and Cortex Dictamni powder;

(3) Herba Cistanches after step (1) being processed and lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Flos Lonicerae, Herba Siegesbeckiae, Radix Salviae Miltiorrhizae, Folium Gleditsiae, Herba Vernoniae Patulae, Radix Curcumae, Flos Sesami and the Radix Astragali are together placed in Chinese medicine pan, add cold water soak 2-3 hour the cold water soak of 7 times of medical material amounts (preferably add 2.5 hours) of 5.5-8.5 times of medical material amount, then the clear water (preferably adding the clear water of 2 times of medical material amounts) of 1-3 times of medical material amount is added, intense fire heated and boiled, turn slow fire boiling three times, first time decocts 40-50 minute (preferably first time decocts 45 minutes), second time decocts 24-38 minute (preferably second time decocts 30 minutes), third time decocts 10-20 minute (preferably third time decocts 15 minutes), merge three decocting liquids, filter, filtrate is for subsequent use,

(4) mixed powder after step (2) being processed joins in above-mentioned filtrate, slow fire heating decocts 18-34 minute (preferred slow fire heating decoction 26 minutes), three layers of cotton cloth filter, step (1) gained Fructus Mori liquid is added in filtrate, stirring makes it mix homogeneously, be cooled to room temperature, encapsulation, to obtain final product.

5. a kind of preparation method for the treatment of the decoction of alopecia totalis according to claim 4, is characterized in that, in step (1), the number of degrees of Chinese liquor are 40 °-60 ° (number of degrees of preferred Chinese liquor are 45 °-55 °, and the number of degrees of the Chinese liquor be more preferably are 50 °).

6. a kind of preparation method for the treatment of the decoction of alopecia totalis according to claim 4, is characterized in that, the middle 85-135 mesh sieve excessively of step (2) (preferred 100-120 mesh sieve excessively, mistake 110 mesh sieve be more preferably).

7. a kind of preparation for the treatment of alopecia totalis as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:

(1) Fructus Ligustri Lucidi and yellow wine are mixed thoroughly (Fructus Ligustri Lucidi: yellow wine=6:1), vexed 8-12 minute (preferably vexed 10 minutes), take out, put in food steamer, and moderate heat heating is steamed 3-6 hour (preferred moderate heat heating steaming 4.5 hours), takes out dry, grinds for subsequent use; Herba Cistanches brushes away surface impurity, and hands is torn into small pieces, in 45-55 DEG C of dry 2.5-5.5 hour (being preferable over 50 DEG C of dryings 4 hours) to exsiccator, takes out and is ground into fine powder, for subsequent use;

(2) by lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Cortex Mori, Herba Siegesbeckiae, Radix Salviae Miltiorrhizae, Herba Vernoniae Patulae, Radix Curcumae, Radix Celastri Angulati, Cortex Dictamni and the Radix Astragali are placed in pulverizer and are together ground into coarse powder, then be placed in percolator, with the ethanol of 30% and the pure water of 70% for solvent, percolation is carried out according to percolation, when the percolate collected is the 22-26 times of raw material medicated powder amount (preferably when the percolate collected is 24 times of raw material medicated powder amount) stop percolation, filter, reclaim ethanol, being evaporated to 78 DEG C of relative densities is the thick paste of 1.18-1.20, drying gets dry extract powder, cool, porphyrize, for subsequent use,

(3) Fructus Mori, Flos Lonicerae, Fructus Ilicis Cornutae, Folium Gleditsiae and Flos Sesami are placed in marmite, add cold water to powder 2-3cm, slow fire heating decoction twice, each respectively decoction 18-30 minute (preferably each each decoction 24 minutes), filtration, filtrate reduced in volume to 85 DEG C relative density is the thick paste of 1.30-1.33, the dried cream powders such as spraying dry, cooling, porphyrize, for subsequent use;

(4) the raw material medicated powder mixing after being processed step (1)-(3), add amylum pregelatinisatum and magnesium stearate (mixed powder: amylum pregelatinisatum: magnesium stearate=6:0.9:0.45), stir, cross 80 mesh sieves, tabletting, to obtain final product.

8. a kind of preparation method for the treatment of the tablet of alopecia totalis according to claim 7, it is characterized in that, in step (2), the mass concentration of ethanol is the mass concentration of the preferred ethanol of 80%-100%(is 85%-95%, and the mass concentration of the ethanol be more preferably is 90%).

9. a kind of preparation for the treatment of alopecia totalis as described in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:

(1) Flos Lonicerae and Flos Sesami are cleaned respectively, dry, and are placed in parch container, and slow fire heats, and fry to dusky, taking-up cools, and grinds to the powder, for subsequent use; Fructus Ligustri Lucidi and Fructus Ilicis Cornutae are fully dry, porphyrize powder, for subsequent use;

(2) Herba Cistanches, Herba Siegesbeckiae, Folium Gleditsiae and Herba Vernoniae Patulae are placed in medicine pot, the clear water adding 4-8 times of raw material dose soaks 30-50 minute (clear water preferably adding 6 times of raw material doses soaks 40 minutes under room temperature) under room temperature, then slow fire heating decoction twice, first time decocts 24-40 minute (preferably first time decocts 32 minutes), second time decocts 14-30 minute (preferably second time decocts 22 minutes), merges twice decocting liquid, filters, filtrate reduced in volume is to paste, for subsequent use;

(3) by lip Rhizoma et radix valerianae, Rhizoma Chuanxiong, Cortex Mori, Radix Salviae Miltiorrhizae, Radix Curcumae, Radix Celastri Angulati, Cortex Dictamni and the Radix Astragali are placed in Chinese medicament extracting device, the mass concentration adding 4-6 times amount is the ethanol of 50%-80% (mass concentration preferably adding 5 times amount is the ethanol of 65%), heating and refluxing extraction twice, reflux, extract, 36-52 minute first time (preferred reflux, extract, for the first time 45 minutes), second time reflux, extract, 20-34 minute (preferably second time reflux, extract, 27 minutes), merge twice alcohol extract, filter, filtrate reduced in volume to 65 DEG C relative density is the thick paste of 1.22-1.25, for subsequent use,

(4) by step (2) and the mixing of step (3) gained thick paste, add the Fructus Mori smashed to pieces, mix thoroughly, add the raw material medicated powder after step (1) process, mechanical agitation, add simultaneously mass fraction be 9.5% sucrose fine and mass fraction be the microcrystalline Cellulose of 5%, mix homogeneously, make the pill of Semen Firmianae size, to obtain final product.

10. a kind of preparation for the treatment of alopecia totalis as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable thick paste agent, preparation method is as follows:

(1) Fructus Ligustri Lucidi, Fructus Ilicis Cornutae grind to form fine powder respectively, for subsequent use; Flos Lonicerae, Folium Gleditsiae and Flos Sesami are placed in traditional Chinese medicine drying device in 55-65 DEG C of dry 32-48 minute (being preferable over 60 DEG C of dryings 40 minutes), take out, are placed in pulverizer and are together ground into fine powder, for subsequent use;

(2) Cortex Mori, Radix Celastri Angulati and Cortex Dictamni are chopped up silk respectively, be placed in parch container, slow fire stir-fries to golden yellow, and taking-up cools, and is ground into fine powder, and the raw material medicated powder after processing with step (1) mixes, and is placed in penetrating bag, for subsequent use;

(3) crude drug except step (1) and (2) is placed in Chinese medicine pan, add clear water and do not have powder 4-5cm, soak under room temperature 1-3 hour (soaking 2 hours under preferred room temperature), then add the penetrating bag of step (2) gained, slow fire heating decoction three times, each respectively decoction 22-36 minute (preferably each each decoction 30 minutes), after decoction terminates, merges three decocting liquids, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.25-1.28, and dry heat sterilization, to obtain final product.