CN105920093A - Medicinal composition for treating eczema - Google Patents

Abstract

The invention discloses a medicinal composition for treating eczema, which is prepared from the following raw material medicines in parts by weight: 14 to 16 parts of panax notoginseng, 14 to 16 parts of ginkgo leaf, 3 to 5 parts of mint, 2 to 4 parts of evening primrose seed oil and 2 to 4 parts of eucalyptus oil. The invention overcomes the defects of an existing medicament for treating eczema and provides the medicinal composition with a good effect of treating eczema.

Description

A kind of pharmaceutical composition treating eczema

Technical field

The present invention relates to technical field of traditional Chinese medicines, be specifically related to a kind of pharmaceutical composition treating eczema.

Background technology

Eczema, is a kind of scytitis reaction of the acute pruritus caused by multiple internal and external factor.Divide anxious Property, three phases subacute, chronic.Acute stage tool oozes out tendency, and chronic phase then infiltrates, plump.Some Patient directly translates into chronic eczema.Skin damages has polymorphy, symmetry, itch and easy recurrent exerbation Etc. feature.The cause of disease, eczematosis, because of complexity, is often internal and external reasons interaction result.Internal cause is the chronicest to disappear Change systemic disease, stress, insomnia, fatigue, emotional change, endocrinopathy, infection, Dysbolisms etc., external cause such as living environment, climate change, food etc. all can affect sending out of eczema Raw.Environmental stimuli such as daylight, cold, be dried, hot, hot water is scalded and various animal skin, Plant, cosmetics, soap, staple fibre etc. all can induce.Be the complicated inside and outside factor cause one Plant delayed allergy.Clinical manifestation, 1. damages performance by skin and is divided into acute, subacute, chronic three Phase.(1) acute eczema skin damages is just the most intensive papule of grain grain size, papulo-vesicle or little water Blister, substrate flush, gradually merge in flakes, owing to scratching, papule, papulo-vesicle or blister top are scratched Ooze out in obvious point-like afterwards and little rotten to the corn face, blur margin.Such as scabies secondary infection, inflammation becomes apparent from, Warts, purulence scab, folliculitis, furuncle etc. can be formed.Conscious violent itch.After being apt to occur in head, ear, Distal limbs, scrotum, crissum etc., many symmetrical issues.(2) subacute eczema acute eczema inflammation After alleviating, skin damages based on little papule, incrustation and the scales of skin that peel off, rarely seen a small amount of papulo-vesicle and erosion.Still have Acutely itch.(3) chronic eczema does not often more transfer to slow because of acute, subacute eczema recurrent exerbation Property eczema；Also can start to be chronic eczema.Show as illing skin to thicken, infiltrate, brownish red or Pigmentation, rough surface, covers the scales of skin that peel off, or forms a scab because scratching.Conscious acute pruritus.It is common in Shank, hand, foot, the fossa cubitalis, nest, vulva, anus etc..The course of disease is indefinite, easily recurs, prolonged Do not heal.2. damage the scope involved according to skin, be divided into limitation eczema and the big class of universal eczema two.(1) Limitation eczema occurs over just privileged site, i.e. can name with position, as wet in hand eczema, cysthus Rash, eczema of scrotum, ear eczema, eczema mammae, perianal eczema, legs eczema etc..(2) general Property eczema skin damage many, general or distribute in the multiple position of whole body.Such as coin eczema, autosensitization Property eczema, weary lipid eczema.

Therefore, research will have important meaning for the Chinese medicine of eczema.

Summary of the invention

The technical problem to be solved in the present invention is the deficiency overcoming existing treatment eczema medicine, it is provided that a kind of The treatment preferable pharmaceutical composition of eczema effect.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries , it is made up of the bulk drug of following weight parts:

Pseudo-ginseng 14-16 part, ginkgo leaf 14-16 part, peppermint 3-5 part, evening primrose oil 2-4 part, eucalyptus Oil 2-4 part.

Preferably, it is made up of the bulk drug of following weight parts:

15 parts of pseudo-ginseng, ginkgo leaf 15 parts, peppermint 4 parts, evening primrose oil 3 parts, volatile oil extracted from eucalyptus' leaves or twigs 3 parts.

The formulation of pharmaceutical composition of the present invention can be that washing lotion, liniment, paste etc. medically can connect The formulation being subject to, their preparation method, supplementary product consumption are carried out by existing common process.

Pharmaceutical composition of the present invention is prepared the most in accordance with the following methods: peppermint is shredded, and uses steamed The method that evaporates extracts volatile oil, and the sealing of volatile oil another device refrigerates, the dregs of a decoction are standby；The dregs of a decoction and pseudo-ginseng, ginkgo leaf Adding 5-10 times of soak by water 2 times, each 1-2 hour, collecting decoction filters, dense, lets cool to phase Between density 1.03-1.10, add evening primrose oil, volatile oil extracted from eucalyptus' leaves or twigs and the volatile oil of extraction, 5% oxybenzene second Ester, stirs and filters after staticly settling 72 hours, and filtrate dispenses, packs, checks, i.e. obtains lotion.

Present invention additionally comprises aforementioned pharmaceutical compositions application in the medicine of preparation treatment eczema.

In pharmaceutical composition side of the present invention, share with pseudo-ginseng, ginkgo leaf, have clearing heat and detoxicating, antibacterial Hemostasis, anticorrosion convergence myogenic effect, be the main ingredient for we；Evening primrose oil, stimulate circulation, Activating aged cells, peppermint, volatile oil extracted from eucalyptus' leaves or twigs share, and have eliminating dampness antipruritic, the merit of expelling pus and promoting granulation, assist main ingredient With disease of curing the disease, therefore it is we's adjuvants.

Pseudo-ginseng, is a jewel in Chinese medicine, remembers in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica Carry: " ginseng qi-tonifying first, pseudo-ginseng enriches blood first, taste with and merit also etc., therefore claim Panax pseudoginseng, for Most precious person in Chinese medicine." nature and flavor: taste is sweet；Micro-hardship；Warm in nature.Gui Jing: return Liver Channel；Stomach warp； The heart channel of Hang-Shaoyin；Lung channel；Large intestine channel.Function: hemostasis；Dissipate blood；Analgesic therapy.Cure mainly: fall flutter the stasis of blood swell, the obstruction of qi in the chest Angina, abdominal mass；Blood stasis is through closing；Dysmenorrhoea；Postpartum, stasis of blood the moon was suffered from abdominal pain；Sore, carbuncle and painful swelling.Usage and dosage: decoct Soup, 3-9 gram；Grind into powder, 1-3 gram；Or enter ball, dissipate.External application: suitable reason, mill juice is coated with；Or grind into powder Dress.Ecological environment: wild under the jungle of hillside, modern cultivates in the foot of the hill of height above sea level 800-1000m more Tiltedly drape over one's shoulders, on mound gentle slope or under artificial cool canopy.Resource distribution: be distributed in Jiangxi, Hubei, Guangdong, The ground such as Guangxi, Sichuan, Yunnan.Wild survivor is the most rare, mostly is cultivation.According to Pharmaceutical Analysis, pseudo-ginseng master Contain six kinds of saponins and sitosterol, Daucosterol, flavone compound.Saponin is the main one-tenth of ginseng Point, to strengthening muscle power, improving Myocardial Oxygen Metabolism, the tolerance improving Animal Anoxia has effect very much.For Monarch drug in a prescription

Ginkgo leaf, for the dry leaf of Ginkgoaceae plant Ginkgo biloba Ginkgo biloba L..Autumn leaf still Gather time green, be dried in time.Generally artificial cultivation.North, cultivation area is to Liaoning, and south reaches Guangdong, From the east of Zhejiang, west reach Shaanxi, Gansu, southwest to Sichuan, Guizhou, the ground such as Yunnan.There is invigorating blood circulation The stasis of blood, removes obstruction in channels to relieve pain, and astringes the lung and relievings asthma, and changes effect of turbid lipopenicillinase.For obstruction of collaterals by blood stasis, chest impediment and cardialgia, Hemiplegia, the deficiency syndrome of the lung coughs and breathes heavily, hyperlipidemia.Medicinal part, the dry leaf of plant.Nature and flavor, sweet, Bitter, puckery, flat.Gui Jing, the thoughts of returning home, lung channel.Effect, promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain, astringe the lung and relieving asthma, Change turbid lipopenicillinase.For ministerial drug

Peppermint, it is pungent cool property sweating antipyretic medicine, external application can control neuralgia, pruitus, fash and Eczema etc..Main component volatile oil, peppermint contains menthol, have antisepsis and sterilization, anti-inflammatory, pain relieving, The effect such as antipruritic.For adjutant.

Evening primrose oil, is the most excellent vegetable oil, and principle active component is unsaturated fat contained by it Linoleic acid plus linolenic acid in acid, total content is about 85%.Evening primrose oil be excellent lubricant and Natural moisture preserving agent.For adjutant.

Volatile oil extracted from eucalyptus' leaves or twigs, for myrtle blue gum Eucalyptus globulus Labill., Lauraceae Plant camphor tree Cinnamomum camphora (L.) Sieb. or above-mentioned two section belongs to other plant warp together The volatile oil that steam distillation obtains.Wind-expelling pain-stopping.For pruitus, neuralgia.For making medicine.

In sum, above all medicines share, and become heat-clearing and damp-drying drug altogether, detoxifying and relieving itching, the agent of expelling pus and promoting granulation, Its mechanism of action is mainly with anti-inflammatory, pain relieving, convergence, anticorrosion, myogenic, clearing heat and detoxicating, antibacterial, only Blood, timid rotten apocenosis etc..

Detailed description of the invention

With specific embodiment, the invention will be further described below, but the invention is not limited in these Embodiment.

Embodiment 1

Pseudo-ginseng 140g, ginkgo leaf 160g, peppermint 110g, evening primrose oil 20g, volatile oil extracted from eucalyptus' leaves or twigs 160g.

Peppermint is shredded, and extracts volatile oil with vapor distillation method, and the sealing of volatile oil another device refrigerates, the dregs of a decoction are standby With；The dregs of a decoction and pseudo-ginseng, ginkgo leaf add 5-10 times of soak by water 2 times, each 1-2 hour, merge and decoct Liquid filters, dense to about 1000ml, lets cool between relative density 1.03-1.10, adds the moon See grass oil, volatile oil extracted from eucalyptus' leaves or twigs and the volatile oil of extraction, the auxiliary material of addition conventional amount used, obtain liniment.

Embodiment 2

Pseudo-ginseng 160g, ginkgo leaf 140g, peppermint 130g, evening primrose oil 40g, volatile oil extracted from eucalyptus' leaves or twigs 140g.

Peppermint is shredded, and extracts volatile oil with vapor distillation method, and the sealing of volatile oil another device refrigerates, the dregs of a decoction are standby With；The dregs of a decoction and pseudo-ginseng, ginkgo leaf add 5-10 times of soak by water 2 times, each 1-2 hour, merge and decoct Liquid filters, dense to about 1000ml, lets cool between relative density 1.03-1.10, adds the moon See grass oil, volatile oil extracted from eucalyptus' leaves or twigs and the volatile oil of extraction, the auxiliary material of addition conventional amount used, obtain paste.

Embodiment 3

Pseudo-ginseng 150g, ginkgo leaf 150g, peppermint 120g, evening primrose oil 30g, volatile oil extracted from eucalyptus' leaves or twigs 150g.

Peppermint is shredded, and extracts volatile oil with vapor distillation method, and the sealing of volatile oil another device refrigerates, the dregs of a decoction are standby With；The dregs of a decoction and pseudo-ginseng, ginkgo leaf add 5-10 times of soak by water 2 times, each 1-2 hour, merge and decoct Liquid filters, dense to about 1000ml, lets cool between relative density 1.03-1.10, adds the moon Seeing grass oil, volatile oil extracted from eucalyptus' leaves or twigs and the volatile oil of extraction, 5% ethyl hydroxy benzoate 5-10ml, it is little that stirring staticly settles 72 Filtering time after, filtrate dispenses, packs, checks, i.e. obtains lotion.

Experimental example 4: the embodiment of the present invention 3 treats eczema clinical observation on the therapeutic effect:

Clinical data: observe patient 38 example altogether.

Observational technique

With this preparation clean and smear affected part, usage and dosage: take lotion 100ml add water 500ml dilution Rear cleaning affected part, clean every time after with undiluted lotion smear affected part (or lotion to soak aseptic dry yarn wet Apply), every day 2 times (the most each 1 time), within 10 days, it is a course for the treatment of, treats 2 courses for the treatment of.

Result

(1), efficacy assessment standard: judge result for the treatment of according to symptom and sign

Recovery from illness: skin damages and recovers normal, does not itches, or has slight gargalesthesia.

Effective: 70% skin damages and recovers normal, and remaining skin damages and gradually takes a turn for the better, with slight itch.

Taking a turn for the better: 30% skin damages and recovers normal, remaining skin damages has plumpness or few liquid to ooze out, with itch Sense, but still can stand.

Invalid: locally skin damages less than improvement standard, or without improving, even deteriorate, symptom is without substantially becoming Change.

(2), result for the treatment of:

Treating eczema 38 example altogether according to above standard, cure 18 examples, effective 12 examples, take a turn for the better 7 examples, Invalid 1 example, total effective rate 97.4%.

Toxic and side effect

The lotion that embodiment 3 obtains during treating patient without significant discomfort.

Conclusion and discussion

By the observation of 38 example patients is treated, prompting: according to above data and clinical observation, this The lotion of invention has notable result for the treatment of to eczema, has easy to use, price in clinical practice The advantage such as cheap, toxic and side effect is little, applied widely, by clinical favorable comment.

As a comparison, present invention applicant is the most respectively to pseudo-ginseng, ginkgo leaf folk prescription, and pseudo-ginseng and silver Contrast test has been done in the combination of apricot leaf, experimental result show the effect of prescription of the present invention considerably beyond more than Contrast experiment's effect.

Claims (3)

1. the pharmaceutical composition treating eczema, it is characterised in that: this pharmaceutical composition be by under The bulk drug stating weight portion is made:

Pseudo-ginseng 14-16 part, ginkgo leaf 14-16 part, peppermint 3-5 part, evening primrose oil 2-4 part, eucalyptus Oil 2-4 part.

The pharmaceutical composition for the treatment of eczema the most according to claim 1, it is characterised in that: should Pharmaceutical composition is made up of the bulk drug of following weight parts:

15 parts of pseudo-ginseng, ginkgo leaf 15 parts, peppermint 4 parts, evening primrose oil 3 parts, volatile oil extracted from eucalyptus' leaves or twigs 3 parts.

3. the pharmaceutical composition according to any one of claim 1-2 is at the medicine of preparation treatment eczema In application.