CN104208534A - Anti-scurf pharmaceutical composition and preparation method thereof - Google Patents
Anti-scurf pharmaceutical composition and preparation method thereof Download PDFInfo
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- CN104208534A CN104208534A CN201410487652.2A CN201410487652A CN104208534A CN 104208534 A CN104208534 A CN 104208534A CN 201410487652 A CN201410487652 A CN 201410487652A CN 104208534 A CN104208534 A CN 104208534A
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- pharmaceutical composition
- dandruff
- scurf
- radix sophorae
- sophorae flavescentis
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Abstract
The invention discloses an anti-scurf pharmaceutical composition. The anti-scurf pharmaceutical composition is composed of, by weight ratio, 10-13 of honey, 12-20 of saponin, 10-13 parts of cortex mori radicis, 15-20 of polygonum cuspidatum, 15-20 parts of radix sophorae flavescentis and 10-13 parts of rhizoma smilacis glabrae. The preparation method of the anti-scurf pharmaceutical composition comprises selecting, drying, smashing, screening and uniformly mixing the saponin, the cortex mori radicis, the polygonum cuspidatum, the radix sophorae flavescentis and the rhizoma smilacis glabrae; dissolving the mixture inside alcohol, performing heated reflux extraction for half an hour, and performing filtering to obtain filter liquor; adding the honey into the filter liquor and performing uniform mixing to obtain the anti-scurf pharmaceutical composition. The anti-scurf pharmaceutical composition is made of crude drugs and accordingly is a safe drug. The anti-scurf pharmaceutical composition has the advantages of being convenient to use and obvious in effects and can be applied to head itch elimination and scurf removal.
Description
Technical field
The present invention relates to pharmaceutical product, particularly relate to external used medicine, relate to the pharmaceutical composition removing dandruff furthermore.
Background technology
Dandruff refers to that scalp corneocyte comes off with the exception of white or Lycoperdon polymorphum Vitt squama form, and this squama come off is the dandruff.Dandruff Producing reason is divided into physiological and pathologic usually, mainly contains: 1. scalp epithelial cell paraplasm causes scalp to come off too fast formation dandruff; 2. head oils and fats too much makes the Epithelial Cell Adhesion that normally comes off, forms dandruff; 3. fungus causes fat secretion too much in scalp surface growth, and scalp growth and the quickening that comes off, form dandruff.In order to eliminate dandruff, there are some anti-dandruff agent products market, common are degrease product, antimicrobial product and cytostatic agent.These anti-dandruff agent are obvious at use initial performances, but stop using or dandruff regenerating easily after life-time service, usually show drug resistance.
Relate in Chinese patent database and remove the application part of dandruff and have: No. 2005101139900 " the decoction bag hairdressing of hair growth promoting, hair color, anti-dandruff loose and preparation method ", No. ZL2012101278509 " a kind of antidandruff agent compositions and preparation method thereof ", No. 2013101559776 " a kind of treat the too much medicine of dandruff ", No. 2013106682847 " a kind of external application Chinese medicine lotion of dispelling dandruff and scalp pomade ".These technical schemes no doubt have the effect of certain anti-dandruff, but how effect there is no from understanding, so people still upgrade in exploration, more effective anti-dandruff medicine.
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition removing dandruff, enable people keep the clean of hair better, quality of making the life better.
Another object of the present invention is to provide the preparation method of the pharmaceutical composition of above-mentioned removal dandruff, enables to realize suitability for industrialized production.
Of the present invention opening one's minds is that multiple antimicrobial component wherein effectively prevent the drug resistance of scalp fungus, the probability reduction that dandruff regenerate from antibacterial, dredging many-sided combined effect such as head pore and nutrition scalp in dandruff.Inventor selects the medicine that can realize this thinking, and raw medicinal material component and the quality proportioning thereof of the pharmaceutical composition of the removal dandruff provided are as follows:
Mel 10 ~ 13, Fructus Gleditsia 15 ~ 20, Cortex Mori 10 ~ 13, Rhizoma Polygoni Cuspidati 15 ~ 20, Radix Sophorae Flavescentis 15 ~ 20, Rhizoma Smilacis Glabrae 10 ~ 13.
In above-mentioned raw materials, the honey of nectar brew in Nidus Vespae that Mel (honey) is insecticide Apis to be adopted from the spending of flowering plant, sweet in the mouth, property is put down, energy invigorating middle warmer, moisturize, pain relieving, removing toxic substances (compiling " Chinese medicine voluminous dictionary " 2481 pages see the new medical college in Zhejiang); Fructus Gleditsia, namely Fructus Gleditsia is that the band pod of leguminous plant Fructus Gleditsia (Gleditsia sinensis) is real, and acrid in the mouth is warm in nature, searches wind, draws out pus by applying a plaster to the affected part, subsides a swelling, evacuation of pus effect (see " Chinese medicine voluminous dictionary " 1144 pages); Cortex Mori, for moraceae plants Mulberry (Morus alba) removes the root bark of cork, sweet in the mouth, cold in nature, there is eliminating pathogen from the lung for relieving asthma, the effect (see " Chinese medicine voluminous dictionary " 1968 pages) of line water detumescence; Rhizoma Polygoni Cuspidati is the rhizome of polygonaceae plant Rhizoma Polygoni Cuspidati (Reynoutria japonica), bitter in the mouth, and property is put down, and can dispel the wind, dampness removing, and removing blood stasis with potent drugs, stimulate the menstrual flow (see " Chinese medicine voluminous dictionary " 1329 pages); Radix Sophorae Flavescentis is the root of leguminous plant Radix Sophorae Flavescentis (Sophora flavescens), and bitter in the mouth is cold in nature, energy heat clearing and damp drying, parasite killing diuresis (see " Chinese medicine voluminous dictionary " 1283 pages); Rhizoma Smilacis Glabrae is the rhizome of liliaceous plant Rhizoma Smilacis Glabrae (Smilax glabra), slightly sweet flavor, and property is put down, and can detoxify, dehumidifying, sharp joint (see " Chinese medicine voluminous dictionary " 91 pages).
Above-mentioned medical material should meet the regulation in " Chinese Pharmacopoeia " nineteen ninety-five version one under each medical material item.
The pharmaceutical composition preparation method of the removal dandruff that inventor provides is: get Fructus Gleditsia, Cortex Mori, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae 5 kinds of medical materials by selected, dry, pulverizing, mix after sieving, add dissolve with ethanol, heating and refluxing extraction half an hour, filter and obtain filtrate; In filtrate, add Mel and mix, the medicine of dandruff must be removed.
The mass fraction of above-mentioned ethanol is 70%.
The temperature of above-mentioned heating and refluxing extraction is 80 DEG C.
In the medicine of above-mentioned removal dandruff, the content of effective ingredient is 20% ~ 60%.
The using method of the pharmaceutical composition of removal dandruff of the present invention is the raw material directly using or be used as to produce anti-dandruff shampoo.
For verifying the antibacterial effect of pharmaceutical composition of the present invention, inventors performed following antibacterial experiment: pharmaceutical composition distilled water of the present invention is diluted the trial target that 2 times, 5 times obtain mass fraction 50% and 20% respectively, prepare 5 groups altogether, often organize 2 SDA culture medium containing 4% olive oil, when being cooled to 40 DEG C ~ 50 DEG C, add by 1: 10 trial target, distilled water, 30% ethanol (in order to dilute extracting solution) that mass fraction is 100%, 50% and 20% respectively, after mixing, make plating medium.Often organize the Malassezia furfur and Pichia sp. of on average smearing inoculation dilution activation respectively.37 DEG C of hatching 24h, observe total plate count, result is as follows:
Table 1: antibacterial experiment result
Result shows pharmaceutical composition of the present invention has better inhibitory action to Malassezia furfur.
Then, inventor has carried out clinical trial again: choose dandruff patient 30 example on probation, wherein men and women respectively accounts for 15 people respectively.People on probation used every two days, and male patient gets this product 4ml, and female patient is got this product 8ml and is applied in moistening root of hair place, and massages 2min gently, followed up a case by regular visits to record before and after all patients use, and used two weeks continuously, Estimating curative effect.
Evaluation criterion: (dandruff disappears in recovery from illness, without pruritus), effectively (dandruff disappears, and substantially substantially disappears, without scratchiness without scratchiness or dandruff), onset (dandruff minimizing, pruritus alleviates), invalid (, without minimizing, pruritus is without alleviating for dandruff).
Table 2: clinical trial result
Result show, the present invention to dandruff patient improvement rate 70.0%, take effect rate 86.7%.
After this pharmaceutical composition Clinical practice, successful.Effective percentage more than 80%.
Typical example is as follows:
Case one: Zhang, man, 45 years old, the long-term dandruff, once used the shampoo of multiple dandruff, as health king, Head&Shoulders etc. all to no effect, use successful after this product 3 times after being introduced instead, rear continuation use 3 months, the dandruff thoroughly disappears, and within 2 years more than a year now, does not recur.
Case two: Wang Mei, female, 32 years old, because the dandruff perplexs more than 10 year, used the multiple dandruff product such as Rejoice, olive oil shampoo, and did not only have effect, wash more and more on the contrary, go to hospital to see and also do not cure.She had the attitude of having a try this product fortnight in arms afterwards, and situation is clearly better, and continues to have used half a year, and the dandruff disappears.Use other shampoos instead and also do not occur the dandruff again.
Case three: thank certain, female, 20 years old, Xian Shang Wuhan South-Center University For Nationalities, within 17 years old, when being in high school, because learning pressure is large, often may feel scalp pruritus, under the wafing as a stingy dandruff picture snows, also with alopecia, all some disliked and avoided her to classmate at one's side.Washed 20 days by this product to her afterwards, afterwards, she feels to have itched before head is, thing like snowflake also without, then use 1 month, dandruff disappears completely.Pass by 3 years now, appointed and change clothes to flood to wash and all no longer include dandruff.
Case four: Li Shiming, man, 28 years old, do manual work in present Guangdong.Winter in 2009, feel head pruritus after haircut, the dandruff is a lot, first thinks it is irritated to shampoo, in a few days will be good; I had never expected that it is all the same for having changed a variety of shampoo; The product that TV is advertised he buy use, got well a period of time, changed other shampoo dandruffs and come again.Introducing through friend has afterwards used this product after two months, and change other shampoo use, head is not itched, and the dandruff disappears, and has thoroughly taken leave of the dandruff.
Case five: inventor suffers from the dandruff in the past, within one day, wash once head, do not wash and just can't stand, when wearing the clothes of black, the dandruff to drop on clothes clearly, see that people is too shy, used a variety of dandruff product all thoroughly not remove, afterwards, inventor works out this product, the Reusability experiment several years.Now, the dandruff without, head has not also been itched.
The pharmaceutical composition of removal dandruff provided by the invention, makes with crude drug, is a kind of safe drugs.It has advantage that is easy to use, successful.Can be used for eliminating head pruritus, removing the dandruff.
Detailed description of the invention
Embodiment gets Fructus Gleditsia, Cortex Mori, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae 5 taste medical material, and selected removal impurity, puts into calorstat successively, pulverizes at 100 DEG C after dry 5min with pulverizer, and screening fineness is respectively 40 object powder; Then get Fructus Gleditsia 180g, Cortex Mori 120g, Rhizoma Polygoni Cuspidati 180g, Radix Sophorae Flavescentis 180g, Rhizoma Smilacis Glabrae 120g mix, add the dissolve with ethanol of mass fraction 70%, be heated to 80 DEG C of reflux, extract, 30min, filter and obtain filtrate; In filtrate, add Mel 120g and mix, obtaining the medicine of removal dandruff of the present invention, wherein the mass content of effective ingredient is 50% ± 10%.
Claims (5)
1. remove a pharmaceutical composition for dandruff, it is characterized in that the raw medicinal material component of this pharmaceutical composition and quality proportioning as follows:
Mel 10 ~ 13, Fructus Gleditsia 15 ~ 20, Cortex Mori 10 ~ 13, Rhizoma Polygoni Cuspidati 15 ~ 20, Radix Sophorae Flavescentis 15 ~ 20, Rhizoma Smilacis Glabrae 10 ~ 13.
2. prepare the method for pharmaceutical composition described in claim 1, it is characterized in that getting Fructus Gleditsia, Cortex Mori, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Rhizoma Smilacis Glabrae 5 kinds of medical materials by selected, dry, pulverizing, mix after sieving, add dissolve with ethanol, heating and refluxing extraction half an hour, filter and obtain filtrate; In filtrate, add Mel and mix, the pharmaceutical composition of dandruff must be removed.
3. method as claimed in claim 2, is characterized in that the mass fraction of described ethanol is 70%.
4. method as claimed in claim 2, is characterized in that the temperature of described heating and refluxing extraction is 80 DEG C.
5. method as claimed in claim 2, is characterized in that the mass content of effective ingredient in the pharmaceutical composition of described removal dandruff is 20% ~ 60%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410487652.2A CN104208534A (en) | 2014-09-22 | 2014-09-22 | Anti-scurf pharmaceutical composition and preparation method thereof |
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| CN201410487652.2A CN104208534A (en) | 2014-09-22 | 2014-09-22 | Anti-scurf pharmaceutical composition and preparation method thereof |
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| CN104208534A true CN104208534A (en) | 2014-12-17 |
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| CN201410487652.2A Pending CN104208534A (en) | 2014-09-22 | 2014-09-22 | Anti-scurf pharmaceutical composition and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107550977A (en) * | 2017-07-31 | 2018-01-09 | 刘作龙 | The Chinese medicine composition for the treatment of of dandruff |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095799A (en) * | 2006-06-30 | 2008-01-02 | 黄振华 | Liquor preparations for removing dandruff and method for preparing the same |
| CN102614102A (en) * | 2012-04-27 | 2012-08-01 | 昆明远方生物制品有限公司 | Dandruff-removing medicinal composition and preparation method thereof |
-
2014
- 2014-09-22 CN CN201410487652.2A patent/CN104208534A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095799A (en) * | 2006-06-30 | 2008-01-02 | 黄振华 | Liquor preparations for removing dandruff and method for preparing the same |
| CN102614102A (en) * | 2012-04-27 | 2012-08-01 | 昆明远方生物制品有限公司 | Dandruff-removing medicinal composition and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 李会周: "中药巧治头皮屑", 《卫生与生活报》 * |
| 李湘奇: "止痒汤临床运用举隅", 《新疆中医药》 * |
| 陈淑君等: "头皮屑的研究进展", 《国外医学皮肤性病学分册》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107550977A (en) * | 2017-07-31 | 2018-01-09 | 刘作龙 | The Chinese medicine composition for the treatment of of dandruff |
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Address after: 622550, 2 building, emergency center, Longgang Town, Pingwu County, Mianyang, Sichuan Applicant after: Xu Dadong Applicant after: Gong Chuanrui Address before: 622550, 2 building, emergency center, Longgang Town, Pingwu County, Mianyang, Sichuan Applicant before: Gong Chuanrui Applicant before: Xu Dadong |
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Inventor after: Xu Dadong Inventor after: Gong Chuanrui Inventor before: Gong Chuanrui Inventor before: Xu Dadong |
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Free format text: CORRECT: APPLICANT; FROM: GONG CHUANRUI TO: XU DADONG Free format text: CORRECT: INVENTOR; FROM: GONG CHUANRUI XU DADONG TO: XU DADONG GONG CHUANRUI |
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Address after: Mianyang City, Sichuan Province town of longan 622550 Pingwu County Emergency Center 2 floor Applicant after: Xu Dadong Applicant after: Gong Chuanrui Address before: 622550, 2 building, emergency center, Longgang Town, Pingwu County, Mianyang, Sichuan Applicant before: Xu Dadong Applicant before: Gong Chuanrui |
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Application publication date: 20141217 |