CN106176784A - A kind of pharmaceutical composition for dermatitis, application, preparation and preparation method thereof - Google Patents
A kind of pharmaceutical composition for dermatitis, application, preparation and preparation method thereof Download PDFInfo
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- CN106176784A CN106176784A CN201610562866.0A CN201610562866A CN106176784A CN 106176784 A CN106176784 A CN 106176784A CN 201610562866 A CN201610562866 A CN 201610562866A CN 106176784 A CN106176784 A CN 106176784A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
Abstract
The present invention discloses a kind of pharmaceutical composition for dermatitis, and described composition component mark meter by weight includes: matrine 3～20 parts, osthole 1～10 parts, momordin Ic2～15 parts, paeonol 3～20 parts, glycyrrhizic acid 8～40 parts, menthol 10～48 parts, bisabolol 5～30 parts；The present invention has antipruritic, antiinflammation, can be used for treating insect dermatitis, contact dermatitis, and instant effect, short treating period, cure rate are high, easy to use, to skin without sensitization and zest；Mature preparation process, quality controllable.
Description
Technical field
The present invention relates to technical field of Chinese medicines field, be specifically related to a kind of pharmaceutical composition for dermatitis, application, preparation
And preparation method thereof.
Background technology
Dermatitis is the abbreviation of a kind of scytitis reaction, and the factor complexity causing dermatitis is various.Can be divided into: contact skin
Inflammation, insect bite dermatitis, neurodermatitis, daylight sunburn dermatitis, drug eruption, steroid-dependent dermatitis etc..The generally cause of disease is:
Chronic disease infects, and endocrine metabolism changes, food, inhalation (inhalatio) allergy etc..The common sympton thus caused has erythema, edema,
With pimple, vesicle or ooze out.
Wherein, contact dermatitis refers to because skin caused after skin or some extraneous morbid substance of mucosal contact is acute
Inflammatory reaction, it is possible to be gradually transformed into chronic dermatitis.Constitutional can be divided to stimulate (such as strong acid, highly basic etc.) and allergy (as dynamic
Physical property, vegetalitas, chemical) two kinds.Contact dermatitis clinical manifestation is erythema, swelling, pimple, vesicle, even bulla, clinical
Finding is caused a disease as common with chemical substance.Constitutional contact dermatitis is found in anyone, and allergy contact dermatitis is only sent out
In a few peoples.The degree of dermatitis depends on sensitization and the reaction of this material.At present, this disease of western medical treatment is typically adopted
Use oral Loratadine, such as Cyproheptadine, this fourth of imidazoles etc.；Severe one, can give glucocorticoid, such as oral prednisone, song
Anxi dragon or dexamethasone, Diprospan intramuscular injection.Said medicine exists that side effect is big, therapeutic effect is poor, at the bottom of cure rate
Not enough.
Insect dermatitis, also known as lichen urticatus, acute simplex prurigo, has sickness rate height, acute pruritus, easily answers
The feature sent out.Skin lesion often shows as the rubella wheal sample infringement of circle or fusiformis, and can there be the syringe needle vesicle to Semen phaseoli radiati size on top, dissipates
Or cluster distribution.Most morbidities are bitten relevant with mosquito, flea louse etc., and patient is bitten rear animal saliva albumen and other polypides
Albumen causes human body generation anaphylaxis, thus the symptoms such as pruritus, welt, vesicle occurs.At present, this disease of western medical treatment is mainly
Using external ointment preparation, it mostly is hormones ointment.Hormone therapy, has obvious non-specific inhibitory action, though after external
The state of an illness can be made to improve rapidly, but it is short-term relief symptom, suppression inflammatory reaction rather than healing inflammation, it is impossible to from all
The upper treatment cause of disease.The abuse of hormone, it is also possible to cause steroid-dependent dermatitis to occur.Treatment papular urticaria also uses external
Various anti-itching lotions, if volume fraction is 1%～2% carbolic acid Calamine Lotion, compound recipe Alumen lotion, dyclonine Emulsion
Deng, hydryllin, vitamin C for oral administration.Easily make patient produce drug dependence during treatment rash, and easily recur.
Summary of the invention
In view of this, the application provides a kind of pharmaceutical composition for dermatitis, application, preparation and preparation method thereof, institute
State medicine composite for curing contact dermatitis and papular evident in efficacy, cure height, natural gentleness, can be with life-time service.
For solving above technical problem, the technical scheme that the present invention provides is a kind of pharmaceutical composition, and described component is by weight
Amount mark meter includes: matrine 3-20 part, osthole 1～10 parts, momordin Ic2～15 parts, paeonol 3-20 part, sweet
Oxalic acid 8～40 parts, menthol 10～48 parts, bisabolol 5～30 parts.
Preferably, described component mark meter by weight includes: matrine 5～15 parts, osthole 1～6 parts, Fructus Kochiae soap
Glycosides Ic2～10 parts, paeonol 5～15 parts, glycyrrhizic acid 15～30 parts, menthol 25～45 parts, bisabolol 8～25 parts
Preferably, described component mark meter by weight includes: matrine 9 parts, osthole 3 parts, momordin Ic6
Part, paeonol 9 parts, glycyrrhizic acid 24 parts, menthol 36 parts, bisabolol 15 parts.
Preferably, the raw material of described compositions is Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Cortex Moutan, Radix Glycyrrhizae, menthol, opopanax
Alcohol.
Preferably, described matrine is the extract of described Radix Sophorae Flavescentis, and described osthole is the extract of described Fructus Cnidii,
Described momordin Ic is the extract of the described Fructus Kochiae, and described paeonol is the extract of described Cortex Moutan, described Radix Glycyrrhizae
Acid is the extract of described Radix Glycyrrhizae.
Preferably, described matrine be described Radix Sophorae Flavescentis through water or alcohol steep, filtrate is collected by filtration, extract obtained；Institute
State osthole be described Fructus Cnidii through water or alcohol steep, filtrate is collected by filtration, extract obtained；Described momordin Ic
For the described Fructus Kochiae through water or alcohol steep, filtrate is collected by filtration, extract obtained；Described paeonol is that described Cortex Moutan is through water
Or alcohol steep, filtrate is collected by filtration, extract obtained；Described glycyrrhizic acid is that described Radix Glycyrrhizae is received through water or alcohol steep, filtration
Collection filtrate is extract obtained.
Preferably, described matrine be described Radix Sophorae Flavescentis through water or volume fraction be 60～95% ethanol in soak 1h～
5d, is collected by filtration filtrate, extract obtained；Described osthole be described Fructus Cnidii through water or volume fraction be 60～95%
Ethanol soaks 1h～5d, filtrate is collected by filtration, extract obtained；Described momordin Ic is that the described Fructus Kochiae is through water or body
Fraction be 60～95% ethanol in soak 1h～5d, filtrate is collected by filtration, extract obtained；Described paeonol is described male
Cortex Moutan through water or volume fraction be 60～95% ethanol in soak 1h～5d, filtrate is collected by filtration, extract obtained；Described sweet
Oxalic acid be described Radix Glycyrrhizae through water or volume fraction be 60～95% ethanol in soak 1h～5d, filtrate is collected by filtration, gained carries
Take thing.
Preferably, described matrine, for taking Radix Sophorae Flavescentis, adds ethanol, described Radix Sophorae Flavescentis and described ethanol volume ratio be 1:(3～
18), room temperature immersion 1～5 times, each 10～40 hours.Reclaiming described ethanol, dilute with dilute tune pH3～4, ether is washed
Washing 1～5 time, isolate described ether, surplus solution adjusts pH11～15, and the dichloromethane extraction adding 1～2 times of volume is biological
Alkali.Reclaiming described dichloromethane, residue is dissolved in a small amount of chloroform.It is subsequently adding the ether of 5～15 times of volumes, places, filter, filter
Liquid is evaporated, and adds petroleum ether, 30 DEG C～60 DEG C of reflux, extract, reclaims described petroleum ether, filters, residue mother liquor concentrations, crystallize,
Extract obtained.
Preferably, described osthole, through taking Fructus Cnidii, adds the ethanol that volume fraction is 60～95%, described Fructus Cnidii
It is 1:(3～18 with described ethanol volume ratio), filter, place and separate out a large amount of white flock precipitate to extracting solution, filter, dense
Contracting, then filter, it is concentrated into without alcohol taste, adds kieselguhr stirring, extract by petroleum ether, chloroform, ethyl acetate successively, united extraction
Liquid, places and separates out crystallization, extract obtained.
Preferably, described momordin Ic, for taking the Fructus Kochiae, adds the ethanol that volume fraction is 60～95%, described Serpentis
Machine tool and described ethanol volume ratio are 1:(5～20), 75～90 DEG C of low-temperature heat reflux, extract, 3～5 hours, extracting solution is with 2500
～the centrifugation of 3500r min-1 processes 10～20 minutes, take supernatant and be evaporated to without alcohol taste.Add appropriate distillation
Water, arranged below 18～30 hours in 10 DEG C, then process 10～20 minutes with the centrifugation of 2500～3500r min-1, on
Clear liquid, with after petroleum ether extraction defat, uses water saturated n-butanol extraction, reclaims described n-butyl alcohol, extract obtained.
Preferably, described paeonol, for taking Cortex Moutan, adds water, described Cortex Moutan and described water volume ratio be 1:(10～
25), adding volume fraction is 2～10% sodium chloride, warm macerating 1～3 hours, distillation, and distillate refrigerated overnight filters, obtains crystalline solid,
Filtrate adds described sodium chloride, recrystallization again, obtains crystallization.Before and after merging, twice gained crystallization, is dried, gained.
Preferably, described glycyrrhizic acid is extracting liquorice, adds water, and described Radix Glycyrrhizae and described water volume ratio are 1:(3～10), boil
Boiling, repeats to extract 2～5 times, each 1～2 hour, united extraction liquid.Recycling design, adds sulphuric acid, separates out brown precipitate, washes,
It is dried, pulverizing, extract obtained.
Preferably, described glycyrrhizic acid is extracting liquorice, and adding volume fraction is 0.5～1.0% ammonia, described Radix Glycyrrhizae and described ammonia
Water volume ratio is 1:(5～20), reflux, extract, 2～5 times, filter, merging filtrate.Adding volume fraction is 60～95% ethanol, quiet
Putting overnight, filter, filtrate concentrates and cools down, and adjusts pH2～3, precipitation after cooling, and centrifugal, 50 DEG C～60 DEG C are dried.Dried slightly
Body thing is soluble in water, adjusts pH6.4～7.4, crosses AB-8 resin, filters, eluting, collects eluent, concentrates, decolouring, and gained extracts
Thing.
Preferably, calculate by dry product, in described Radix Sophorae Flavescentis extract, matrine mass fraction >=98.0%；By dry product
Calculate, in described Fructus cnidii extract, described osthole mass fraction >=95.0%；Calculate by dry product, the described Fructus Kochiae
In extract, described momordin Ic mass fraction >=87.0%；Calculate by dry product, in described Cortex Moutan extract, press
Dry product calculates, described paeonol mass fraction >=98.0%；Calculate by dry product, in described Radix Glycyrrhizae extract, described Radix Glycyrrhizae
Acid mass fraction >=98.0%.
Preferably, described raw materials by weight portion meter includes: Radix Sophorae Flavescentis 100～500 parts, Fructus Cnidii 50～400 parts, the Fructus Kochiae
50～400 parts, Cortex Moutan 150～1000 parts, Radix Glycyrrhizae 200～2000 parts, menthol 10～48 parts, bisabolol 5～30 parts.
Preferably, described raw materials by weight portion meter includes: Radix Sophorae Flavescentis 150～450 parts, Fructus Cnidii 100～350 parts, Fructus Kochiae
Son 100～350 parts, Cortex Moutan 250～900 parts, Radix Glycyrrhizae 400～1900 parts, menthol 25～45 parts, bisabolol 8～25 parts.
Preferably, described raw materials by weight portion meter includes: Radix Sophorae Flavescentis 200～400 parts, Fructus Cnidii 150～300 parts, Fructus Kochiae
Son 150～300 parts, Cortex Moutan 300～850 parts, Radix Glycyrrhizae 500～1800 parts, menthol 30～42 parts, bisabolol 10～20
Part.
Preferably, described raw materials by weight portion meter includes: Radix Sophorae Flavescentis 360 parts, Fructus Cnidii 225 parts, the Fructus Kochiae 225 parts, male
Cortex Moutan 600 parts, 1200 parts of Radix Glycyrrhizae, menthol 36 parts, bisabolol 15 parts.
The present invention also provides for the application in the medicine of preparation treatment dermatitis of a kind of described compositions.
Preferably, described dermatitis is insect dermatitis, contact dermatitis.
The present invention also provides for a kind of drug combination preparation for dermatitis, by described compositions and pharmaceutically acceptable
Adjuvant make.
Preferably, one or many during described dosage form is gel, tablet, capsule, granule, pill, oral liquid, plaster
Kind.
Preferably, described dosage form is gel.
Preferably, described matrine mass percent in described gel is 0.1%～6.0%；Osthole is described
In gel, mass percent is 0.05%～5.0%；Momordin mass percent in described gel be Ic0.1%～
5.0%；Paeonol mass percent in described gel is 0.1～6.0%；Glycyrrhizic acid extract is quality hundred in described gel
Proportion by subtraction is 0.1～10.0%；Menthol mass percent in described gel is 0.2%～2.0%；Bisabolol is described solidifying
In glue, mass percent is 0.1～8.0%.
Preferably, described matrine mass percent in described gel is 0.1%～3.0%；Osthole is described
In gel, mass percent is 0.05%～2.0%；Momordin mass percent in described gel be Ic0.1%～
2.0%；Paeonol mass percent in described gel is 0.1%～3.0%；Glycyrrhizic acid extract is quality in described gel
Percentage ratio is 0.1%～8.0%；Menthol mass percent in described gel is 0.2%～1.8%；Bisabolol is in institute
Stating mass percent in gel is 0.1%～4.0%.
Preferably, described matrine mass percent in described gel is 0.3%；Osthole is matter in described gel
Amount percentage ratio is 0.1%；Momordin mass percent in described gel is Ic 0.2%；Paeonol is in described gel
Mass percent is 0.3%；Glycyrrhizic acid extract mass percent in described gel is 0.8%；Menthol is at described gel
Middle mass percent is 1.2%；Bisabolol mass percent in described gel is 0.5%.
The present invention also provides for the application in the medicine of preparation treatment dermatitis of a kind of described composite preparation.
Preferably, described dermatitis is insect dermatitis, contact dermatitis.
The present invention also provides for the preparation method of a kind of pharmaceutical composition for dermatitis, in parts by weight, by Radix Sophorae Flavescentis
Alkali 5～15 parts, osthole 1～6 parts, momordin Ic2～10 parts, paeonol 5-15 part, glycyrrhizic acid 15～30 parts, Herba Menthae
Alcohol 25～45 parts, bisabolol 8～25 parts, mix in a solvent, obtain described compositions.
Preferably, described solvent is ethanol.
Preferably, described ethanol is dehydrated alcohol.
Preferably, described ethanol be volume fraction be the ethanol of 95%.
Preferably, in the present invention, parts by weight are in gram.
In herein described technical scheme:
Matrine: be the root by leguminous plant Radix Sophorae Flavescentis, stem, fruit through a kind of alkaloid of the organic solvent extraction such as ethanol,
Belong to the derivant lupin alkaloids of quinolizidine kind；It is dissolved in cold water, ethanol, ether, chloroform and benzene, is insoluble in oil
Ether, dissolubility is more medium and small than at cold water in the hot water；Have antibacterial, relieving asthma, the multiple pharmacological effect such as leukocyte increasing.
Osthole: be a kind of material extracted from the fruit of Umbelliferae annual herb plant Fructus Cnidii, outward
See as yellow green to white crystalline powder；Water insoluble and cold petroleum ether, is soluble in acetone, methanol, ethanol, chloroform, three chloromethanes
Alkane, ethyl acetate, dissolve in the petroleum ether of boiling；Chemical name is osthole；There is spasmolytic, fall
Blood pressure, arrhythmia, enhancing immunologic function and broad-spectrum antibacterial action.
Momordin Ic: for the one-tenth of Chenopodiaceae annual herb plant Fructus Kochiae Kochia scoparia (L.) Schrad
Ripe fruit；Belong to triterpene saponin；There is the effect such as clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.
Paeonol: can be prepared by extracting in Chinese medicine Cortex Moutan and Chinese medicine Radix Cynanchi Paniculati, it is possible to chemosynthesis；Chemical name is 2-
Hydroxyl-4-methoxyacetophenone；Paeonol；2'-hydroxyl-4'-methoxyacetophenone；There is analgesia, antiinflammatory, antipyretic and suppression change
The effect of state reaction；To the pain caused by the pressure physically or chemically factor such as tail, acetic acid, there is obvious analgesic activity；To by angle
The caused inflammatory reactions such as fork dish glue, Ovum Gallus domesticus album, formaldehyde, histamine, 5-hydroxy tryptamine, Kallidin I, dimethylbenzene and endotoxin, have bright
Aobvious inhibitory action；The body temperature causing Typhoid Vaccine, triple vaccine etc. raises, and has obvious refrigeration function.To II, III,
IV allergic reaction type is respectively provided with inhibitory action.
Glycyrrhizic acid: come from root and the rhizome of glycyrrhizic legume, is topmost active component in Radix Glycyrrhizae；White is to micro-Huang
Color crystalline powder, does not has abnormal smells from the patient, has special sweet taste to extract from liquorice root；Chemical name be (3 β, 20
β) the positive olive of-20-carboxyl-11-oxo-30--12-alkene-3-base-2-O-β-D-glycopyranosyl-α-D-glucopyranose aldehyde
Acid；Glycyrrhizic acid has antiinflammatory, antiviral and protecting liver and detoxication and strengthens the effects such as immunologic function；Glycyrrhizic acid has adrenal cortex and swashs
Element sample effect, can suppress capillary permeability, alleviate the symptom of anaphylactic shock, owing to glycyrrhizic acid has glucocorticoid sample medicine
Reason effect and without serious adverse reaction, also there is the functions such as anti-cancer and cancer-preventing, interferon inducer and cell immunomodulator.
Menthol: derive from labiate Herba Menthae Mentho haplocalyx Bing) herb, Herba Lysimachiae Glechoma
Longituba (Nakai) Kupr. herb, point Folium Perillae Perilla frutescens (L.) Britt.var.Acuto (Thunb.)
Kudo leaf.Chemical name: [1R-(1 α, 2 β, 5 α)]-5-methyl-2-(1-Methylethyl) Hexalin；Mentholum；Terpene alcohol-[3]；
To alkane-3-alcohol；[1R-(1A, 2B, 5A)]-5-methyl-2-(1-Methylethyl)；2-isopropyl-5-methyl cyclohexanol.Effect: make
For skin or mucosa, there is refrigerant itching-relieving action；For oral administration can be used for has a headache and nose, pharynx, laryngitis etc..
Bisabolol: a kind of composition being present in Chamomile, is a kind of monocyclic sesquiterpene alcohol, chemical name: α-
4-dimethyl ester-α-(4-methyl ester-3-pentane alcohol)-3-cycloheptanone-1-methanol；Α-bisabolol；Bisabolol, Α-4-diformazan
Ester-Α-(4-methyl ester-3-pentane alcohol)-3-cycloheptanone-1-methanol；Sweet [terpene] alcohol；Bisabolence terpene alcohol；6-methyl-2-
(4-methyl-3-cyclohexene-1-base)-5-heptene-2-alcohol.Effect: antiinflammatory, promotes wound healing, anti-microbial effect.
Radix Sophorae Flavescentis: for the root of pulse family perennial fallen leaves semishrub plant Radix Sophorae Flavescentis Sophora flavescens Ait..Nature and flavor:
Bitter, cold in nature.Return liver, kidney, large intestine, small intestinal, bladder, heart channel.Effect: heat clearing and damp drying；Wind dispelling insecticide.Main damp-heat dysentery；Hemorrhoidal hamorrhage is just
Blood；Jaundice；Dysuria；Edema；Leukorrhagia；Pudendal pruritus；Scabies；Leprosy；Skin pruritus；Noxious dampness skin infection.Matrine has antiinflammatory, anti-
Allergy, immunomodulating, anti-virus sterilizing, calmness, antipruritic, antipyretic, cooling etc. acts on
Fructus Cnidii: for the dry mature fruit of samphire cnidium monnieri Cnidium monnieri (L.) Cuss..Property
Taste: acrid, bitter, warm.Return kidney channel.Effect: warming the kidney to invigorate YANG, dampness, dispel the wind, parasite killing.For sexual impotence, cold womb, cold-damp band
Under, arthralgia chiefly caused by damp pathogen lumbago；External treatment vulval eczema, married woman's pudendal pruritus；Trichomonal vaginitis.
The Fructus Kochiae: for the dry mature fruit of chenopod Fructus Kochiae Kochia scoparia (L.) Schrad..Nature and flavor:
Pungent, bitter, cold.Return kidney, bladder warp.Effect: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema,
Skin pruritus.
Cortex Moutan: for the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor: bitter,
Cool.GUIXIN, liver, kidney, lung meridian.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.
Radix Glycyrrhizae: for dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., swollen fruit
Radix Glycyrrhizae G.inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G.glabra L..Nature and flavor: sweet are flat.Return spleen, stomach, lung meridian.Merit
Effect: QI invigorating invigorating middle warmer；Relieving spasm to stop pain；Nourishing the lung to arrest cough；Eliminating fire and detoxication；Coordinating the actions of various ingredients in a prescription.
Radix Glycyrrhizae: for glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza
Inflata Bat. or the dry root and rhizome of Glycyrrhiza glabra L. Glycyrrhiza glabra L..Spring, season in autumn two excavate, and remove
Fibrous root, dries.Nature and flavor: sweet are flat.Enter spleen, heart stomach, lung meridian, enter sufficient cloudy, lunar, shaoyin channel of fainting.Effect: invigorating the spleen and replenishing QI, heat clearing away solution
Poison, expelling phlegm for arresting cough, clear throat, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, expectorant of coughing
Many, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Compared with prior art, its detailed description is as follows for the application: clinical drug of the present invention uses and shows to have the following advantages:
(1) Chinese herbal medicine selected by the present invention all meets Pharmacopoeia of the People's Republic of China regulation, and according to compatibility, prescription closes
Reason, select YAOJING good, to skin without sensitization and zest, without essence pigment, natural gentleness, can life-time service, formula is applicable to
Infant and adult；
(2) present invention has antipruritic, antiinflammation, provides with insect dermatitis for treatment dermatitis especially contact dermatitis
A kind of new compositions and preparation thereof, and instant effect, short treating period, cure rate is high, easy to use, easily accepted by patient；
(3) mature preparation process of the present invention, quality controllable；
Detailed description of the invention
The invention discloses a kind of pharmaceutical composition for dermatitis, application, preparation and preparation method thereof, art technology
Personnel can use for reference present disclosure, is suitably modified technological parameter and realizes.Special needs to be pointed out is, all similar replacements and changing
Dynamic apparent to those skilled in the art, they are considered as being included in the present invention.The method of the present invention and should
With being described by preferred embodiment, related personnel substantially can be without departing from present invention, spirit and scope
Method described herein and application it is modified or suitably changes and combine, realize and apply the technology of the present invention.
Below in conjunction with embodiment, the present invention it is expanded on further:
Embodiment 1
The present invention provides a kind of described pharmaceutical composition and the preparation method of described composition gels, described composition component
Mark meter by weight includes: matrine 9 parts, osthole 3 parts, momordin Ic6 part, paeonol 9 parts, glycyrrhizic acid 24 parts,
Menthol 36 parts, bisabolol 15 parts；Parts by weight are in gram；
1, said components is dissolved in appropriate dehydrated alcohol, makes settled solution, obtain described compositions；
2, the described settled solution 1050 parts of PEG-50 castor oil hydrogenated with 55-70 DEG C, nonyl phenol polyethers-14 are mixed also
Stirring, obtains emulsified dose and is rolled into clear oil thing；
3, by propylene glycol and distilled water by after 5 parts of carbomer composition moistenings, place so that carbomer is the most swelling, formed
Aquation colloid；
4, by step 2) in clear oil thing mix homogeneously with distilled water, formed and watery stablize solution；
5, when stirring, by step 4) in aqueous stabilizing solutions be slowly added into step 3) in aquation colloid
In, make 3000 parts of gluey mixture；
6, in colloidal mixture, adding triethanolamine modulation pH value is 6.5, and uniform gel, to obtain final product.
Embodiment 2～5
The present embodiment 2～5 is with the difference of embodiment 1: described pharmaceutical composition component formula is shown in Table 1.
Table 1 pharmaceutical composition of the present invention component formula
Embodiment 6～12
The raw material that embodiment 6 compositions of the present invention uses is Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Cortex Moutan, Radix Glycyrrhizae, thin
Lotus alcohol, bisabolol；Wherein, described osthole, described momordin Ic, described paeonol, described glycyrrhizic acid are respectively
Described Radix Sophorae Flavescentis, described Fructus Cnidii, the described Fructus Kochiae, described Cortex Moutan, the extract of described Radix Glycyrrhizae, parts by weight in gram, institute
State composition of raw materials and be shown in Table 2.
Table 2 pharmaceutical composition of the present invention composition of raw materials
Embodiment 13
The extracting method of pharmaceutical composition component of the present invention is:
Taking Radix Sophorae Flavescentis decoction pieces, add ethanol, described Radix Sophorae Flavescentis decoction pieces and described ethanol volume ratio are 1:8, room temperature immersion 3 times, often
Secondary 24 hours.Reclaiming described ethanol, dilute with dilute tune pH3～4, ether washs 2 times, isolates described ether, residue
Solution adds NaOH and adjusts pH12～14, adds the dichloromethane extraction alkaloid of 1 times of volume.Reclaim described dichloromethane, residue
It is dissolved in a small amount of chloroform.Being subsequently adding the ether of 10 times of volumes, place, filter, filtrate is evaporated, and adds petroleum ether, 30 DEG C～60
DEG C reflux, extract, reclaims described petroleum ether, filters, and remains mother liquor concentrations, crystallize, obtains extract；
Take Fructus Cnidii decoction pieces, add concentration be volume fraction be the ethanol of 95%, described Fructus Cnidii decoction pieces and described ethanol
Volume ratio is 1:8, filters, and places and separates out a large amount of white flock precipitate to extracting solution, filters, and concentrates, then filters, is concentrated into nothing
Alcohol taste, adds kieselguhr stirring, extracts by petroleum ether, chloroform, ethyl acetate successively, united extraction liquid, place and separate out crystallization, obtain
Extract；
Take Fructus Kochiae decoction pieces coarse powder, add concentration be isopyknic volume fraction be 95% ethanol be 75% with volume fraction
Ethanol, described Fructus Cnidii decoction pieces and described ethanol cumulative volume than for 1:10,85 DEG C of low-temperature heat reflux, extract, 4 hours, extracting solution
With 3000r min-1Centrifugation process 15 minutes, take supernatant and be evaporated to without alcohol taste.Add appropriate distilled water, in
10 DEG C are arranged below 24 hours, then with 3000r min-1Centrifugation process 15 minutes, supernatant petroleum ether extraction defat
After, use water saturated n-butanol extraction, reclaim described n-butyl alcohol, obtain extract；
Taking Cortex Moutan decoction pieces, add water, described Cortex Moutan decoction pieces and described water volume ratio are 1:15, and adding volume fraction is 5%
Sodium chloride, warm macerating 2 hours, distillation, distillate refrigerated overnight, filter, obtain crystalline solid, filtrate adds described sodium chloride again, recrystallization,
Must crystallize.Twice clean crystalline substance of gained before and after merging, is dried, obtains extract；
Extracting liquorice decoction pieces coarse powder, adds water, and described licorice piece coarse powder and described water volume ratio are 1:6, boil, and repeats to extract
6 times, each 1 hour, united extraction liquid.Recycling design, to original volume 1/3rd, adds concentrated sulphuric acid, separates out brown precipitate, washes,
60 DEG C of temperature below are dried, and pulverizing obtains extract.
Embodiment 14
The present embodiment is with the difference of embodiment 13: described glycyrrhizic acid is extracting liquorice decoction pieces coarse powder, adds volume fraction and is
0.5% ammonia, described licorice piece coarse powder and described ammonia volume ratio are 1:10, reflux, extract, 2 times, filter, merging filtrate.Add
Volume fraction is 95% ethanol, stands overnight, filter, filtrate concentrates and cools down, add after cooling 3.5mol/L sulphuric acid tune pH2～
3, precipitation, centrifugal, 50 DEG C～60 DEG C are dried.Dried runic thing is soluble in water, adjusts pH6.4～7.4, crosses AB-8 resin, depends on
Secondary water, ethanol elution, collect alcohol eluen, concentrates, activated carbon decolorizing, obtains extract.
Embodiment 15
Antiinflammatory experiment (Inhibition test of xylol of the present invention cause mice auricle swelling)
1, medicament:
1.1 experimental grouies: composition gels described in embodiment 1 to embodiment 5, difference numbered 1～5；
1.2 positive controls: commercially available fluocinonide cream.2, animal: KM (Kunming kind) mice is big by Chengdu Chinese medicine
Experimental Animal Center provides.
3, experimental technique: select the healthy mice 70 of body weight 18 22g, all-male, be randomly divided into 7 groups by body weight, specifically
It is divided into blank group, experimental group 1～experimental group 5, positive controls.Being administered by table 3, often group mouse right ear embrocates medicinal liquid, often
Secondary 0.1mL, every day 2 times, each 1 time of upper and lower noon, continuous 4 days, 30min after last coating, smears dimethylbenzene by often organizing mouse right ear
50 μ L cause inflammation, carry out test processes after causing scorching 50min.
4, experimental result: calculate swelling and suppression ratio, the results are shown in Table 3.
Table 3 xylol of the present invention causes the Inhibition test result of mice auricle swelling
| Packet | Number of animals (only) | Medicament | Swelling (mg) | Suppression ratio (%) |
| Blank group | 10 | Distilled water | 34.30±12.65 | — |
| Experimental group 1 | 10 | Embodiment 1 | 18.80±5.56 | 45.19 |
| Experimental group 2 | 10 | Embodiment 2 | 14.80±6.76 | 56.85 |
| Experimental group 3 | 10 | Embodiment 3 | 18.60±7.70 | 45.77 |
| Experimental group 4 | 10 | Embodiment 4 | 16.80±5.46 | 51.02 |
| Experimental group 5 | 10 | Embodiment 5 | 19.80±6.55 | 42.27 |
| Positive controls | 10 | FUQINGSONG RUGAO | 9.20±1.70 | 73.18 |
As can be seen from the above table, real experimental group 1～experimental group 5 xylol cause mice auricle swelling have well suppression
Effect, positive controls, although its suppression ratio is higher, but positive controls medicament FUQINGSONG RUGAO is hormones ointment, is
According to patience therapeutant, using child and have side effect, easily there is dependence facial dermatitis in life-time service, and local pigment is calm,
The symptoms such as hirsutism.And the application uses pure Chinese medicinal components, there is no hormone, dependence will not be produced, be free from side effects.
Embodiment 16 antiinflammatory experiment (present invention Inhibition test to carrageenin cause rat paw edema)
1, medicament:
1.1 experimental grouies: composition gels described in embodiment 1 to embodiment 5, respectively numbered A～E.；
1.2 positive controls: commercially available fluocinonide cream.
2, animal: SD rat, is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.
3, experimental technique: select the healthy rat 70 of body weight 120 180g, all-male, be randomly divided into 7 groups by body weight, tool
Body is divided into blank group, experimental group A～experimental group E, positive controls.Being administered by table 4, often the group right sufficient sole of the foot of mice is coated with and applies medicinal lotion or ointment
Liquid, each 0.1mL, every day 2 times, at each 1 time of upper and lower noon, continuous 4 days, 30min after last coating, in Rat Right metapedes plantar aponeurosis
Hemostasis 1% carrageenin 0.05ml causes inflammation, use rat foot claw volume measuring apparatus measure cause scorching before and cause after inflammation 1,2,4,6,
8h rat's foot volume.
4, experimental result: calculate each time point rat paw edema rate, the results are shown in Table 4.
Table 4 embodiment 6 present invention causes the Inhibition test result of rat paw edema to carrageenin
As can be seen from the above table, experimental group A～experimental group E has well suppression to carrageenin cause rat paw edema
Effect, for commercially available matched group, although its suppression ratio is higher, but commercially available matched group medicament FUQINGSONG RUGAO is amcinonide
Cream, is according to patience therapeutant, uses child and have side effect, dependence facial dermatitis, and local pigment easily occurs in life-time service
The symptoms such as calmness, hirsutism.And the application uses pure Chinese medicinal components, there is no hormone, dependence will not be produced, be free from side effects.
(suppression that xylol of the present invention causes the increase of mouse web portion capillary permeability is real for the experiment of embodiment 17 antiinflammatory
Test)
1, medicament
1.1 experimental grouies: composition gels described in embodiment 1 to embodiment 5, respectively numbered a～e；
1.2 positive controls: commercially available fluocinonide cream.
2, animal: KM (Kunming kind) mice, is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.
3, experimental technique: select the healthy mice 70 of body weight 18 22g, all-male, be randomly divided into 7 groups by body weight, specifically
It is divided into blank group, experimental group a～experimental group e, positive controls.It is administered by table 5, is often coated with on group mouse web portion skin of unhairing
Apply medicinal lotion or ointment liquid, each 0.4ml/ only, every day 2 times, each 1 time of upper and lower noon, continuous 4 days, last be administered after after 30min, quiet through mouse tail
Arteries and veins injects 0.5% azovan blue normal saline solution 0.1ml/10gB.W., immediately on position, mouse web portion skin of unhairing center
Melted paraxylene 0.03ml/ only, carries out agent treated after 20min, measure A value (absorbance) after 3 days.
4, experimental result: test A value and suppression ratio, the results are shown in Table 5.
Table 5 xylol of the present invention causes the Inhibition test result that mouse web portion capillary permeability increases
| Packet | Number of animals (only) | Medicament | A value | Suppression ratio (%) |
| Blank group | 10 | Distilled water | 0.66±0.18 | — |
| Experimental group a | 10 | Embodiment 1 | 0.27±0.09 | 59.09 |
| Experimental group b | 10 | Embodiment 2 | 0.27±0.08 | 60.06 |
| Experimental group c | 10 | Embodiment 3 | 0.39±0.09 | 40.90 |
| Experimental group d | 10 | Embodiment 4 | 0.33±0.11 | 50.00 |
| Experimental group e | 10 | Embodiment 5 | 0.29±0.08 | 56.06 |
| Positive controls | 10 | FUQINGSONG RUGAO | 0.15±0.03 | 77.27 |
As can be seen from the above table, experimental group a～experimental group e xylol cause mouse web portion capillary permeability increases tool
There is good inhibition, for commercially available matched group, although its suppression ratio is higher, but commercially available matched group medicament FUQINGSONG RUGAO
For hormones ointment, being according to patience therapeutant, use child and have side effect, easily there is dependence facial dermatitis in life-time service, with
And the symptom such as local pigment calmness, hirsutism.And the application uses pure Chinese medicinal components, there is no hormone, dependence will not be produced, there is no pair
Effect.
Embodiment 18 antiinflammatory experiment (present invention causes, to histamine, the Inhibition test that mouse skin capillary permeability increases)
1, medicament:
1.1 experimental grouies: composition gels described in embodiment 1 to embodiment 5, difference numbered I～V；
1.2 positive controls: commercially available cyproheptadine hydrochloride cream.
2, animal: SD rat, is provided by Chengdu University of Traditional Chinese Medicine's Experimental Animal Center.
3, experimental technique: select the healthy SD rat 70 of body weight 180 220g, all-male, be randomly divided into 7 groups by body weight,
It is specifically divided into blank group, group I～experimental group V, positive controls.Being administered by table 6, often group rat carries on the back in its unhairing
Medicinal liquid is embrocated in portion, each 0.4ml/, every day 2 times, each 1 time of upper and lower noon, continuous 4 days.30min after last administration, tail vein is noted
Penetrate 1% azovan blue normal saline solution 0.4ml/10gB.W., immediately at position, back coating center intradermal injection 0.1% phosphorus
Acid histamine 0.1ml/ only, carries out agent treated after 30min, measure A value (absorbance) after 3 days.
4, experimental result: test A value and suppression ratio, the results are shown in Table 6.
Table 6 present invention causes, to histamine, the Inhibition test result that mouse skin capillary permeability increases
| Packet | Number of animals (only) | Medicament | A value | Suppression ratio (%) |
| Blank group | 10 | Distilled water | 0.48±0.11 | — |
| Group I | 10 | Embodiment 1 | 0.20±0.08 | 43.33 |
| Experimental group II | 10 | Embodiment 2 | 0.36±0.17 | 55.06 |
| Experimental group III | 10 | Embodiment 3 | 0.23±0.10 | 52.08 |
| Experimental group IV | 10 | Embodiment 4 | 0.28±0.11 | 41.67 |
| Experimental group V | 10 | Embodiment 5 | 0.22±0.08 | 54.17 |
| Positive controls | 10 | Cyproheptadine hydrochloride cream | 0.14±0.03 | 70.83 |
As can be seen from the above table, group I～experimental group V cause mouse skin capillary permeability to histamine increases tool
There is good inhibition, for commercially available matched group, although its suppression ratio is higher, but commercially available matched group medicament cyproheptadine hydrochloride
Emulsifiable paste is hormones ointment, is according to patience therapeutant, uses child and have side effect, and dependency skin easily occurs in life-time service
Inflammation, and the symptom such as local pigment calmness, hirsutism.And the application uses pure Chinese medicinal components, there is no hormone, dependence will not be produced,
It is free from side effects.
The antipruritic experiment of embodiment 19 (present invention causes the impact experiment reacted of itching to histamine phosphate)
1, medicament:
1.1 experimental grouies: composition gels described in embodiment 1 to embodiment 5, difference numbered I～5；
1.2 positive controls: commercially available cyproheptadine hydrochloride cream.
2, animal: Cavia porcellus (Britain's kind), is provided by plant of laboratory animal special commission of Sichuan Province.
3, experimental technique: select the healthy guinea pig 70 of body weight 250 300g, male and female half and half, be randomly divided into 7 by body weight
Group, is specifically divided into blank group, experimental group 1～experimental group 5, positive controls.Being administered by table 7, before experiment, often group Cavia porcellus is right
Rear instep shaving, area 1cm2, embrocate medicinal liquid every day 2 times, the upper and lower noon is each once, continuous 4 days, and experiment is wiped when daily coarse sandpaper
Hinder behind the right side at the shaving of instep, be allowed to rubescent, but with the most hemorrhage for degree, local coating twice again, it is spaced 1 hour, after last coating
10min, starts only to be coated with 0.01% histamine phosphate 50 μ L/ at wound surface, and the most every 3min passs according to 0.02%, 0.03%, 0.04%
Enrichment degree, is only 50 μ L/, until occurring that Cavia porcellus gives the total amount of histamine phosphate when later licking right metapedes is that cause is itched every time
Threshold.The results are shown in Table 7.
Table 7 present invention on histamine phosphate cause itch reaction affect experimental result
| Packet | Number of animals (only) | Medicament | Itch-threshold (μ g) |
| Blank group | 10 | Distilled water | 0.13±0.09 |
| Experimental group 1 | 10 | Embodiment 1 | 0.46±0.18 |
| Experimental group 2 | 10 | Embodiment 2 | 0.51±0.43 |
| Experimental group 3 | 10 | Embodiment 3 | 0.48±0.30 |
| Experimental group 4 | 10 | Embodiment 4 | 0.50±0.28 |
| Experimental group 5 | 10 | Embodiment 5 | 0.45±0.09 |
| Positive controls | 10 | Cyproheptadine hydrochloride cream | 0.71±0.40 |
As can be seen from the above table, histamine phosphate is caused to itch in reaction by experimental group 1～experimental group 5, and its itch-threshold is the highest,
For commercially available matched group, although its itch-threshold is higher, but commercially available matched group medicament cyproheptadine hydrochloride cream is hormones ointment,
Being according to patience therapeutant, use child and have side effect, easily there is dependence facial dermatitis in life-time service, and local pigment sinks
, the symptom such as hirsutism.And the application uses pure Chinese medicinal components, there is no hormone, dependence will not be produced, be free from side effects.
Embodiment 20 skin allergy is tested
1, medicament:
1.1 experimental grouies: composition gels described in embodiment 1 to embodiment 5, difference numbered I～5；
1.2 positive controls: 2,4-dinitro-chloro-benzene.
2, animal: Cavia porcellus (white Britain kind), is provided by plant of laboratory animal special commission of Sichuan Province.
3, experimental technique: select the healthy guinea pig 70 of body weight 250 300g, male and female half and half, be randomly divided into 7 by body weight
Group, is specifically divided into positive controls (give 2,4-dinitro-chloro-benzene), experimental group 1～experimental group 5 and (gives embodiment 1 to reality
Execute preparation described in example 5), blank group (giving distilled water).Experiment proxima luce (prox. luc), by skin shaving (area on the right side of guinea pig back
For 3cm2), test the same day, at shaving district, right side daubing medicament 0.2mL, then cover with one layer of oilpaper and two-layer gauze, then with
Non-stimulated immobilization with adhesive tape, continues to wash away for 6 hours medicine, and observed the situations such as skin allergy in hereafter 24,48,72 hours.
4, calculating sensitization rate, experimental result is shown in Table 8.
Table 8 embodiment 8 skin allergy experimental result
| Packet | Number of animals (only) | Medicament | Sensitization rate (%) |
| Blank group | 10 | Distilled water | 0 |
| Experimental group 1 | 10 | Embodiment 1 | 0 |
| Experimental group 2 | 10 | Embodiment 2 | 0 |
| Experimental group 3 | 10 | Embodiment 3 | 0 |
| Experimental group 4 | 10 | Embodiment 4 | 0 |
| Experimental group 5 | 10 | Embodiment 5 | 0 |
| Positive controls | 10 | 2,4-dinitro-chloro-benzene | 100 |
More than 21 skin irritation test of embodiment
1, medicament: composition gels described in embodiment 1 to embodiment 5, difference numbered I～5.
2, animal: rabbit, Japan large ear rabbit, male and female half and half, plant of laboratory animal special commission of Sichuan Province provide.
3, experimental technique: select healthy rabbits 15, be randomly divided into 5 groups, be specifically divided into experimental group (1 5), use self
Left and right sides compares.With 8% sodium sulfide be in rabbit back depilation, each 3cm × 3cm of unhairing scope arranged on left and right sides.Check before being administered and go
Fur skin is injured because of unhairing, and injured skin should not be tested, and next day is at depilation district, back daubing medicament, wherein left
Side skin distilled water compares, and right side gives preparation described in embodiment 1 to embodiment 5, once a day, continuous 14 days, every time
Smearing rear 4h, wash away residue with warm water, after observing drug withdrawal, there are the feelings of erythema and edema in 1,24,48,72 hours skin of back
Condition.
4, experimental result is shown in Table 7.
Table 7 embodiment 9 skin irritation test result
Note: "None" is to occur without erythema edema.
The medicine composite for curing example that embodiment 22 present invention provides
Case 1:
Name: Zhao, sex: man, the age: 31 years old, consultation time on 07 26th, 2014, occupation: Kuai Xiao product enterprise pin
Vender manages, area: Chongqing, symptom: external application muscular soreness plaster, and there is an intensive pimple at back, local skin flushing, companion's swelling,
Skin Lightening, superficial makings disappear, and examine as contact dermatitis, use the pharmaceutical composition gel that the embodiment of the present invention 1 provides, and 1
Day 3 times, uniform application is in dermatitis happening part, and after 1 day, symptom alleviates, and swelling is substantially disappeared, and fully recovers after 3 days, the most remaining skin lesion trace
Mark.
Case 2:
Name: Zhang, sex: female, the age: 28 years old, consultation time on 07 11st, 2015, occupation: mall shopping, ground
District: Kweiyang, Guizhou, symptom: external application use traumatic injury plaster, back lumbar part plaster viscose local occur boundary more clearly color of the leather flushing,
Swelling, around there is the pimple being dispersed in, use the pharmaceutical composition gel that the embodiment of the present invention 2 provides, 3 times on the 1st, symptom after 1 day
Alleviating, recovery from illness on the 2nd, without skin lesion vestige.
Case 3:
Name: remaining certain, sex: man, the age: 40 years old, consultation time on 06 08th, 2015, occupation: decoration worker, ground
District: Sichuan Meishan, symptom: premorbid has a paint contact history, local swelling, erubescence, see have intensive pimple, local to burn
Heat, examines as contact dermatitis.Using the pharmaceutical composition gel that the embodiment of the present invention 3 provides, 3 times on the 1st, the same day, symptom alleviated,
Fully recover after one week, without skin lesion vestige.
Case 4:
Name: Liu, sex: man, the age: 19 years old, consultation time on 01 17th, 2016, occupation: certain colleges and universities big are learned
Raw, area: Chengdu, Sichuan, symptom: after using adhesive bandage, boundary more clearly color of the leather flushing occurs in viscose local, the scorchinggest hot,
Pruritus, examines as contact dermatitis.Using the pharmaceutical composition gel that the embodiment of the present invention 4 provides, 3 times on the 1st, the same day, symptom subtracted
Gently, fully recover after 2 days, without skin lesion vestige.
Case 5
Name: revive certain, sex: female, the age: 22 years old, consultation time December in 2015 17 days, occupation: public institution civilian,
Area: Chengdu, Sichuan, symptom: have skin allergy history, belongs to sensitive skin, and after using newly purchased leather glove, skin of dorsum of hand occurs
Color of the leather flushing, the scorchinggest hot, pruritus, examine as contact dermatitis.The pharmaceutical composition gel that the use embodiment of the present invention 5 provides, 1
Day 3 times, after 1 day, symptom alleviates, and fully recovers, without skin lesion vestige after 3 days.
Case 6
Name: revive certain, sex: female, the age: 2 years old half, consultation time on 05 10th, 2016, area: zhuzhou,hunan, disease
Shape: multiple subfusiform welts occur in trunk, both legs, there are little pimple, violent pruritus in indivedual welt central authorities, and children's's scratching does not stops,
Examining as insect bite dermatitis, use the pharmaceutical composition gel that the embodiment of the present invention 1 provides, 5 to 6 times on the 1st, welt local, after 2 days
Symptom alleviates, and fully recovers, have deeper skin lesion vestige after one week.After following up a case by regular visits to 3 months, skin lesion vestige disappears.
Case 7
Name: field, sex: female, the age: 10 years old, consultation time on June 10th, 2015, area: Deyang, Sichuan, symptom:
Occur in wire outside arm or streak redness, above have intensive pimple, conscious scorching hot, pain, examine as (rove beetle) insect bite
Property dermatitis, use the embodiment of the present invention 2 provide pharmaceutical composition gel, local use 5 to 6 times on the 1st, the same day, symptom alleviated,
Fully recover after one week, have deeper skin lesion vestige.
Case 8
Name: Liu, sex: man, the age: 31 years old, consultation time on June 15th, 2016, area: Chengdu, Sichuan, symptom:
There are multiple subfusiform welts in the region such as the left hand back of the body, shoulder, waist, has swelling, accompanies violent pruritus, examines as insect bite dermatitis,
Using the pharmaceutical composition gel that the embodiment of the present invention 3 provides, local to use 5 to 6 times on the 1st, symptom alleviated on 2nd, reduced after 4 days
For middle finger size erythema, fully recover after one week, have deeper skin lesion vestige.
Case 9
Name: Wang, sex: man, the age: 27 years old, consultation time on August 01st, 2015, area: Chongqing, symptom: shank
There are multiple Semen Glycines size pimples in tripe region, accompanies violent pruritus, examines as insect bite dermatitis, uses the embodiment of the present invention 4 to provide
Pharmaceutical composition gel, local uses 5 to 6 times on the 1st, and symptom alleviated at that time, and the same day fully recovers, and leaves minimum red papules sample skin
Damage, follow up a case by regular visits to pimple sample skin lesion and disappear after 5 days.
Case 10
Name: Zhao, sex: female, the age: 23 years old, consultation time on 06 28th, 2016, area: Suining, Sichuan, disease
, there is the most intensive subfusiform, red papules not of uniform size, accompanies violent pruritus, examine as insect bite skin in shape: both feet at ankle
Inflammation, uses the pharmaceutical composition gel that the embodiment of the present invention 5 provides, local to use 5 to 6 times on the 1st, and symptom alleviated at that time, one week
Rear recovery from illness, leaves minimum red papules sample skin lesion, follows up a case by regular visits to pimple sample skin lesion and disappears after two weeks.
Below it is only the preferred embodiment of the present invention, it is noted that it is right that above-mentioned preferred implementation is not construed as
The restriction of the present invention, protection scope of the present invention should be as the criterion with claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, it is also possible to make some improvements and modifications, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (10)
1. the pharmaceutical composition for dermatitis, it is characterised in that described composition component mark meter by weight includes: Radix Sophorae Flavescentis
Alkali 3-20 part, osthole 1～10 parts, momordin Ic2～15 parts, paeonol 3～20 parts, glycyrrhizic acid 8～40 parts, Herba Menthae
Alcohol 10～48 parts, bisabolol 5～30 parts.
Pharmaceutical composition the most according to claim 1, it is characterised in that described component mark meter by weight includes: Radix Sophorae Flavescentis
Alkali 5～15 parts, osthole 1～6 parts, momordin Ic2～10 parts, paeonol 5-15 part, glycyrrhizic acid 15～30 parts, Herba Menthae
Alcohol 25～45 parts, bisabolol 8～25 parts.
Pharmaceutical composition the most according to claim 1, it is characterised in that the raw material of described compositions be Radix Sophorae Flavescentis, Fructus Cnidii,
The Fructus Kochiae, Cortex Moutan, Radix Glycyrrhizae, menthol, bisabolol.
Pharmaceutical composition the most according to claim 3, it is characterised in that described matrine is the extract of described Radix Sophorae Flavescentis,
Described osthole is the extract of described Fructus Cnidii, and described momordin Ic is the extract of the described Fructus Kochiae, described pellet
Skin phenol be the extract of described Cortex Moutan, described glycyrrhizic acid be the extract of described Radix Glycyrrhizae.
Pharmaceutical composition the most according to claim 3, it is characterised in that described raw materials by weight portion meter includes: Radix Sophorae Flavescentis
100～500 parts, Fructus Cnidii 50～400 parts, the Fructus Kochiae 50～400 parts, Cortex Moutan 150～1000 parts, Radix Glycyrrhizae 200～2000 parts,
Menthol 10～48 parts, bisabolol 5～30 parts.
6. according to compositions described in any one of Claims 1 to 5 preparation treatment dermatitis medicine in application.
Application the most according to claim 6, it is characterised in that described dermatitis is insect dermatitis, contact dermatitis.
8. the preparation for the pharmaceutical composition of dermatitis, it is characterised in that combined by described in any one of Claims 1 to 5
Thing and pharmaceutically acceptable adjuvant are made.
9. the preparation method for the pharmaceutical composition of dermatitis, it is characterised in that in parts by weight, by matrine 5
～15 parts, osthole 1～6 parts, momordin Ic2～10 parts, paeonol 5-15 part, glycyrrhizic acid 15～30 parts, menthol
25～45 parts, bisabolol 8～25 parts, mix in a solvent, obtain described compositions.
Preparation method the most according to claim 9, it is characterised in that described solvent is ethanol.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497353A (en) * | 2015-12-25 | 2016-04-20 | 成都爱可依生物科技有限公司 | Chinese herbal preparation for preventing and controlling children dermatosis and preparing method and application thereof |
| CN110917058A (en) * | 2019-12-30 | 2020-03-27 | 福州百草堂医药科技有限公司 | Cosmetic agent for relieving skin irritation and preparation method thereof |
| CN112843113A (en) * | 2021-03-23 | 2021-05-28 | 南京医科大学 | A preparation for treating contact dermatitis |
| CN113144037A (en) * | 2021-03-03 | 2021-07-23 | 上海沐芙乐医疗科技有限公司 | A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000271A (en) * | 2010-11-10 | 2011-04-06 | 胡广芹 | Oral medicament for removing acne |
| CN105687432A (en) * | 2016-03-16 | 2016-06-22 | 烟台市华文欣欣医药科技有限公司 | Application of traditional Chinese medicine composition in preparation of medicines for treating eczema |
-
2016
- 2016-07-18 CN CN201610562866.0A patent/CN106176784B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000271A (en) * | 2010-11-10 | 2011-04-06 | 胡广芹 | Oral medicament for removing acne |
| CN105687432A (en) * | 2016-03-16 | 2016-06-22 | 烟台市华文欣欣医药科技有限公司 | Application of traditional Chinese medicine composition in preparation of medicines for treating eczema |
Non-Patent Citations (2)
| Title |
|---|
| 邱海荣: ""红没药醇和姜醇的协同抗炎性研究"", 《万方学位论文》 * |
| 齐红艺等: ""薄荷醇促渗透作用的研究进展"", 《时珍国医国药》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105497353A (en) * | 2015-12-25 | 2016-04-20 | 成都爱可依生物科技有限公司 | Chinese herbal preparation for preventing and controlling children dermatosis and preparing method and application thereof |
| CN110917058A (en) * | 2019-12-30 | 2020-03-27 | 福州百草堂医药科技有限公司 | Cosmetic agent for relieving skin irritation and preparation method thereof |
| CN113144037A (en) * | 2021-03-03 | 2021-07-23 | 上海沐芙乐医疗科技有限公司 | A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema |
| CN112843113A (en) * | 2021-03-23 | 2021-05-28 | 南京医科大学 | A preparation for treating contact dermatitis |
| CN112843113B (en) * | 2021-03-23 | 2022-02-01 | 南京医科大学 | A preparation for treating contact dermatitis |
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| CN106176784B (en) | 2019-01-29 |
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