CN113144037A - A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema - Google Patents
A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema Download PDFInfo
- Publication number
- CN113144037A CN113144037A CN202110234605.7A CN202110234605A CN113144037A CN 113144037 A CN113144037 A CN 113144037A CN 202110234605 A CN202110234605 A CN 202110234605A CN 113144037 A CN113144037 A CN 113144037A
- Authority
- CN
- China
- Prior art keywords
- parts
- herbal medicine
- chinese herbal
- pwp300
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/76—Salicaceae (Willow family), e.g. poplar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a skin external preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components, which comprises the following components: PWP 300: 18-36 parts; olive oil: 30-50 parts; the Chinese herbal medicine comprises the following components: 9-18 parts; the second Chinese herbal medicine composition: 9-18 parts. The external skin preparation for improving atopic dermatitis and infantile eczema based on the PWP300 plant components is prepared from green, non-toxic and side-effect-free Chinese herbal medicine components, has broad-spectrum anti-inflammatory and anti-redness and skin barrier repair effects, does not cause side effects such as immunosuppression and hormone-dependent dermatitis after long-term use, has undoubtedly better effect when being used for treating dry and itching skin diseases compared with the existing medicine, is coordinated by adding the olive oil into the preparation, has the effects of moistening the skin and removing wrinkles, can enable the skin to be smoother and more comfortable, is added with the first Chinese herbal medicine component and the second Chinese herbal medicine component, and is assisted by selecting the Chinese herbal medicine with the effects of diminishing inflammation, resisting bacteria, relieving itching, inhibiting inflammation and the like.
Description
Technical Field
The invention relates to the field of dermatitis, in particular to a skin external preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components.
Background
In recent years, with the accelerated progress of industrialization, urbanization and aging in China, the prevalence rate of various chronic inflammatory dermatosis is in a continuous and rapid increasing trend. Atopic Dermatitis (AD) is the most common chronic, recurrent inflammatory skin disease in adolescent children, manifested as systemic dryness, severe itching. The morbidity of developed countries in Europe and America reaches 10% -20%, national morbidity data is not available in China, but the prevalence rate of AD of children is gradually increased along with the deepening of industrialization. The questionnaire survey in 11 provinces of China in 1998 consistently found that the prevalence rate of AD at that time was 0.69%, while the survey of 2010 by Xu et al on 10436 preschool children suggested that the prevalence rate of AD in Shanghai was 8.3%. AD is often accompanied by severe pruritus and sleep disturbance, is easy to chronically prolong and repeatedly attack, and seriously affects the personal and family life quality of patients.
For the explanation of PWP300, PWP is a plant complex extract, specifically purslane extract, white willow bark extract, peony root bark extract, several acronyms for the main ingredients, and 300 is a code number.
Clinically, the first-line external medicament for treating atopic dermatitis is glucocorticoid cream, but long-term external application of the glucocorticoid cream can cause various side effects such as skin atrophy, folliculitis, hormone system absorption and the like.
In view of the above, there is a strong need in the art to develop an effective ingredient containing plant extracts as main ingredients, which can alleviate dryness and itching of atopic dermatitis, without side effects.
Disclosure of Invention
The present invention has been made to solve the above problems occurring in the background art, and an object of the present invention is to provide a skin external preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components.
In order to achieve the purpose, the invention provides the following technical scheme:
a skin external preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components, comprising:
PWP 300: 18-36 parts;
olive oil: 30-50 parts;
the Chinese herbal medicine comprises the following components: 9-18 parts;
the second Chinese herbal medicine composition: 9-18 parts.
As a further scheme of the invention: the PWP300 is composed of purslane extract, white willow bark extract, peony root bark extract and ferulic acid.
As a still further scheme of the invention: the ratio of the herba portulacae extract, the white willow bark extract, the peony root bark extract and the ferulic acid component is 2:2:2: 1.
As a still further scheme of the invention: the preparation process of the PWP300 is as follows:
the method comprises the following steps: selecting fresh stems and leaves of purslane without wormholes, extracting the stems and leaves of the purslane by adopting a low-temperature extraction method to obtain an extract with biological activity, and dissolving the extract in a butanediol solution with a certain concentration to obtain a purslane extract;
step two: selecting weeping willow of fifteen years, taking off tree slices without wormholes from the weeping willow, drying the tree slices, grinding the tree slices after drying, and sieving the tree slices through a 200-mesh sieve after grinding to obtain a white willow bark extract;
step three: selecting root bark of medicinal parts of peony root bark, cortex moutan and peony root, cleaning, drying, grinding after drying, and sieving by a 200-mesh sieve to obtain a peony root bark extract;
step four: extracting ferulic acid from cell wall of Ferula plant;
step five: mixing the purslane extract, the white willow bark extract, the peony root bark extract and the ferulic acid obtained in the first step, the second step, the third step and the fourth step according to the ratio of 2:2:2:1, and putting the mixture into a stirring kettle for stirring to obtain the PWP 300.
As a still further scheme of the invention: the Chinese herbal medicine component I comprises 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of tuber fleeceflower stem, 28 parts of common camptotheca bark, 25 parts of coptis chinensis, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts of erythrina bark and 300 parts of components.
As a still further scheme of the invention: the preparation process of the herbal medicine component I is as follows:
the method comprises the following steps: selecting the following raw materials for later use: 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of Japanese climbing fern vine, 28 parts of common camptotheca bark, 25 parts of coptis root, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts and 300 parts of erythrina bark;
step two: the prepared fructus cnidii 10 parts, the broom cypress fruit saponin Ic15 parts, the tuber fleeceflower stem 15 parts, the cortex ilicis chinensis 28 parts, the coptis chinensis 25 parts, the houttuynia cordata 25 parts, the platycodon grandiflorum 15 parts and the erythrina bark 25 parts are poured into 300 parts of spring water to be soaked for 48 hours, and a solid-liquid mixture A is obtained;
step three: pouring the solid-liquid mixture A prepared in the step two into a decocting pot, decocting the mixture for 1.5 hours with strong fire, pouring out the medicinal liquid to obtain medicinal liquid A, adding 300 parts of spring water into the decocting pot again, and decocting the mixture for 2 hours with strong fire again to obtain medicinal liquid B;
step four: mixing the medicinal liquid A and the medicinal liquid B prepared in the three steps, uniformly stirring, and concentrating for 3 hours to obtain a medicinal liquid A;
step five: filtering the liquid medicine A prepared in the four steps by a filter screen of 220 meshes, and filtering out dregs of decoction to obtain the Chinese herbal medicine component I.
As a still further scheme of the invention: the second Chinese herbal medicine component consists of 20 parts of matrine, 48 parts of menthol and 30 parts of bisabolol.
As a still further scheme of the invention: the preparation process of the Chinese herbal medicine component II comprises the following steps:
the method comprises the following steps: selecting dried radix Sophorae Flavescentis, pulverizing, extracting, and extracting with ethanol to obtain matrine;
step two: selecting aerial parts of herba Menthae, such as stems, branches, leaves and inflorescences, performing steam distillation to obtain crude oil of herba Menthae, and then obtaining menthol from the crude oil of herba Menthae;
step three: selecting chamomile flowers as raw materials, and extracting bisabolol from the chamomile flowers;
step four: and (3) mixing the matrine and the menthol bisabolol prepared in the first step, the second step and the third step according to the proportion of 20 parts: 48 parts of: pouring 30 parts of the mixture into a stirring kettle, stirring and mixing the mixture, and preparing the Chinese herbal medicine component II after uniformly stirring the mixture.
As a still further scheme of the invention: the preparation process comprises the following steps:
the method comprises the following steps: preparing the following raw materials for later use: PWP 300: 18-36 parts of olive oil: 30-50 parts of a first Chinese herbal medicine component: 9-18 parts of Chinese herbal medicine composition II: 9-18 parts;
step two: introducing all the raw materials prepared in the step one into a stirring kettle for stirring, wherein the stirring time is 3 hours, and the rotating speed of the stirring kettle is 500r/min, so as to prepare a raw material finished product;
step three: performing spot inspection on the raw material finished product prepared in the step two, and checking whether the raw material finished product is qualified;
step four: and if the spot inspection in the third step is qualified, packaging and sterilizing the product.
Compared with the prior art, the invention has the beneficial effects that:
1. the traditional Chinese medicine composition is prepared from green, non-toxic and side-effect-free Chinese herbal medicine components, has broad-spectrum anti-inflammatory, red-fading and skin barrier repairing effects, does not cause side effects such as immunosuppression and hormone-dependent dermatitis after long-term use, has better effect when being used for treating dry and itching skin diseases undoubtedly compared with the existing medicines, is extracted from green pure natural plants, and is also suitable for treating infantile eczema.
2. The olive oil is added into the medicament for coordination, and the olive oil has the effects of moistening the skin and removing wrinkles, so that the skin is smoother and more comfortable.
3. According to the invention, through the addition of the Chinese herbal medicine component I and the Chinese herbal medicine component II, Chinese herbal medicines with the effects of diminishing inflammation, resisting bacteria, relieving itching, inhibiting inflammation and the like are selected for assistance, so that the using effect of the medicament is improved, and the bisabolol is beneficial to increasing the penetrability of components in the medicament and further is beneficial to improving the using effect of the medicament.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
The first embodiment is as follows:
a skin external preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components, comprising:
PWP 300: 18 parts of a mixture;
olive oil: 30 parts of (1);
the Chinese herbal medicine comprises the following components: 9 parts of (1);
the second Chinese herbal medicine composition: 9 parts.
PWP300 is composed of purslane extract, white willow bark extract, peony root bark extract and ferulic acid component.
The ratio of the herba portulacae extract, the white willow bark extract, the peony root bark extract and the ferulic acid component is 2:2:2: 1.
The preparation procedure of PWP300 is as follows:
the method comprises the following steps: selecting fresh stems and leaves of purslane without wormholes, extracting the stems and leaves of the purslane by adopting a low-temperature extraction method to obtain an extract with biological activity, and dissolving the extract in a butanediol solution with a certain concentration to obtain a purslane extract;
step two: selecting weeping willow of fifteen years, taking off tree slices without wormholes from the weeping willow, drying the tree slices, grinding the tree slices after drying, and sieving the tree slices through a 200-mesh sieve after grinding to obtain a white willow bark extract;
step three: selecting root bark of medicinal parts of peony root bark, cortex moutan and peony root, cleaning, drying, grinding after drying, and sieving by a 200-mesh sieve to obtain a peony root bark extract;
step four: extracting ferulic acid from cell wall of Ferula plant;
step five: mixing the purslane extract, the white willow bark extract, the peony root bark extract and the ferulic acid obtained in the first step, the second step, the third step and the fourth step according to the ratio of 2:2:2:1, and putting the mixture into a stirring kettle for stirring to obtain the PWP 300.
The first Chinese herbal medicine component consists of 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of tuber fleeceflower stem, 28 parts of camptotheca acuminata peel, 25 parts of coptis chinensis, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts of erythrina bark and 300 parts of components.
The preparation process of the first herbal medicine component is as follows:
the method comprises the following steps: selecting the following raw materials for later use: 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of Japanese climbing fern vine, 28 parts of common camptotheca bark, 25 parts of coptis root, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts and 300 parts of erythrina bark;
step two: the prepared fructus cnidii 10 parts, the broom cypress fruit saponin Ic15 parts, the tuber fleeceflower stem 15 parts, the cortex ilicis chinensis 28 parts, the coptis chinensis 25 parts, the houttuynia cordata 25 parts, the platycodon grandiflorum 15 parts and the erythrina bark 25 parts are poured into 300 parts of spring water to be soaked for 48 hours, and a solid-liquid mixture A is obtained;
step three: pouring the solid-liquid mixture A prepared in the step two into a decocting pot, decocting the mixture for 1.5 hours with strong fire, pouring out the medicinal liquid to obtain medicinal liquid A, adding 300 parts of spring water into the decocting pot again, and decocting the mixture for 2 hours with strong fire again to obtain medicinal liquid B;
step four: mixing the medicinal liquid A and the medicinal liquid B prepared in the three steps, uniformly stirring, and concentrating for 3 hours to obtain a medicinal liquid A;
step five: filtering the liquid medicine A prepared in the four steps by a 220-mesh filter screen, and filtering out dregs to obtain the Chinese herbal medicine component I.
The second Chinese herbal medicine component consists of 20 parts of matrine, 48 parts of menthol and 30 parts of bisabolol.
The preparation process of the Chinese herbal medicine component II comprises the following steps:
the method comprises the following steps: selecting dried radix Sophorae Flavescentis, pulverizing, extracting, and extracting with ethanol to obtain matrine;
step two: selecting aerial parts of herba Menthae, such as stems, branches, leaves and inflorescences, performing steam distillation to obtain crude oil of herba Menthae, and then obtaining menthol from the crude oil of herba Menthae;
step three: selecting chamomile flowers as raw materials, and extracting bisabolol from the chamomile flowers;
step four: and (3) mixing the matrine and the menthol bisabolol prepared in the first step, the second step and the third step according to the proportion of 20 parts: 48 parts of: pouring 30 parts of the mixture into a stirring kettle, stirring and mixing the mixture, and preparing the Chinese herbal medicine component II after uniformly stirring the mixture.
A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema is prepared by the following steps:
the method comprises the following steps: preparing the following raw materials for later use: PWP 300: 18 parts, olive oil: 30 parts of Chinese herbal medicine component one: 9 parts of Chinese herbal medicine composition II: 9 parts of (1);
step two: introducing all the raw materials prepared in the step one into a stirring kettle for stirring, wherein the stirring time is 3 hours, and the rotating speed of the stirring kettle is 500r/min, so as to prepare a raw material finished product;
step three: performing spot inspection on the raw material finished product prepared in the step two, and checking whether the raw material finished product is qualified;
step four: and if the spot inspection in the third step is qualified, packaging and sterilizing the product.
Example two:
a skin external preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components, comprising:
PWP 300: 27 parts of (1);
olive oil: 40 parts of a mixture;
the Chinese herbal medicine comprises the following components: 13.5 parts;
the second Chinese herbal medicine composition: 13.5 parts.
PWP300 is composed of purslane extract, white willow bark extract, peony root bark extract and ferulic acid component.
The ratio of the herba portulacae extract, the white willow bark extract, the peony root bark extract and the ferulic acid component is 2:2:2: 1.
The preparation procedure of PWP300 is as follows:
the method comprises the following steps: selecting fresh stems and leaves of purslane without wormholes, extracting the stems and leaves of the purslane by adopting a low-temperature extraction method to obtain an extract with biological activity, and dissolving the extract in a butanediol solution with a certain concentration to obtain a purslane extract;
step two: selecting weeping willow of fifteen years, taking off tree slices without wormholes from the weeping willow, drying the tree slices, grinding the tree slices after drying, and sieving the tree slices through a 200-mesh sieve after grinding to obtain a white willow bark extract;
step three: selecting root bark of medicinal parts of peony root bark, cortex moutan and peony root, cleaning, drying, grinding after drying, and sieving by a 200-mesh sieve to obtain a peony root bark extract;
step four: extracting ferulic acid from cell wall of Ferula plant;
step five: mixing the purslane extract, the white willow bark extract, the peony root bark extract and the ferulic acid obtained in the first step, the second step, the third step and the fourth step according to the ratio of 2:2:2:1, and putting the mixture into a stirring kettle for stirring to obtain the PWP 300.
The first Chinese herbal medicine component consists of 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of tuber fleeceflower stem, 28 parts of camptotheca acuminata peel, 25 parts of coptis chinensis, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts of erythrina bark and 300 parts of components.
The preparation process of the first herbal medicine component is as follows:
the method comprises the following steps: selecting the following raw materials for later use: 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of Japanese climbing fern vine, 28 parts of common camptotheca bark, 25 parts of coptis root, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts and 300 parts of erythrina bark;
step two: the prepared fructus cnidii 10 parts, the broom cypress fruit saponin Ic15 parts, the tuber fleeceflower stem 15 parts, the cortex ilicis chinensis 28 parts, the coptis chinensis 25 parts, the houttuynia cordata 25 parts, the platycodon grandiflorum 15 parts and the erythrina bark 25 parts are poured into 300 parts of spring water to be soaked for 48 hours, and a solid-liquid mixture A is obtained;
step three: pouring the solid-liquid mixture A prepared in the step two into a decocting pot, decocting the mixture for 1.5 hours with strong fire, pouring out the medicinal liquid to obtain medicinal liquid A, adding 300 parts of spring water into the decocting pot again, and decocting the mixture for 2 hours with strong fire again to obtain medicinal liquid B;
step four: mixing the medicinal liquid A and the medicinal liquid B prepared in the three steps, uniformly stirring, and concentrating for 3 hours to obtain a medicinal liquid A;
step five: filtering the liquid medicine A prepared in the four steps by a 220-mesh filter screen, and filtering out dregs to obtain the Chinese herbal medicine component I.
The second Chinese herbal medicine component consists of 20 parts of matrine, 48 parts of menthol and 30 parts of bisabolol.
The preparation process of the Chinese herbal medicine component II comprises the following steps:
the method comprises the following steps: selecting dried radix Sophorae Flavescentis, pulverizing, extracting, and extracting with ethanol to obtain matrine;
step two: selecting aerial parts of herba Menthae, such as stems, branches, leaves and inflorescences, performing steam distillation to obtain crude oil of herba Menthae, and then obtaining menthol from the crude oil of herba Menthae;
step three: selecting chamomile flowers as raw materials, and extracting bisabolol from the chamomile flowers;
step four: and (3) mixing the matrine and the menthol bisabolol prepared in the first step, the second step and the third step according to the proportion of 20 parts: 48 parts of: pouring 30 parts of the mixture into a stirring kettle, stirring and mixing the mixture, and preparing the Chinese herbal medicine component II after uniformly stirring the mixture.
A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema is prepared by the following steps:
the method comprises the following steps: preparing the following raw materials for later use: PWP 300: 27 parts, olive oil: 40 parts of Chinese herbal medicine component A: 13.5 parts of Chinese herbal medicine composition II: 13.5 parts;
step two: introducing all the raw materials prepared in the step one into a stirring kettle for stirring, wherein the stirring time is 3 hours, and the rotating speed of the stirring kettle is 500r/min, so as to prepare a raw material finished product;
step three: performing spot inspection on the raw material finished product prepared in the step two, and checking whether the raw material finished product is qualified;
step four: and if the spot inspection in the third step is qualified, packaging and sterilizing the product.
Example three:
a skin external preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components, comprising:
PWP 300: 36 parts of (A);
olive oil: 50 parts of a mixture;
the Chinese herbal medicine comprises the following components: 18 parts of a mixture;
the second Chinese herbal medicine composition: and 18 parts.
PWP300 is composed of purslane extract, white willow bark extract, peony root bark extract and ferulic acid component.
The ratio of the herba portulacae extract, the white willow bark extract, the peony root bark extract and the ferulic acid component is 2:2:2: 1.
The preparation procedure of PWP300 is as follows:
the method comprises the following steps: selecting fresh stems and leaves of purslane without wormholes, extracting the stems and leaves of the purslane by adopting a low-temperature extraction method to obtain an extract with biological activity, and dissolving the extract in a butanediol solution with a certain concentration to obtain a purslane extract;
step two: selecting weeping willow of fifteen years, taking off tree slices without wormholes from the weeping willow, drying the tree slices, grinding the tree slices after drying, and sieving the tree slices through a 200-mesh sieve after grinding to obtain a white willow bark extract;
step three: selecting root bark of medicinal parts of peony root bark, cortex moutan and peony root, cleaning, drying, grinding after drying, and sieving by a 200-mesh sieve to obtain a peony root bark extract;
step four: extracting ferulic acid from cell wall of Ferula plant;
step five: mixing the purslane extract, the white willow bark extract, the peony root bark extract and the ferulic acid obtained in the first step, the second step, the third step and the fourth step according to the ratio of 2:2:2:1, and putting the mixture into a stirring kettle for stirring to obtain the PWP 300.
The first Chinese herbal medicine component consists of 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of tuber fleeceflower stem, 28 parts of camptotheca acuminata peel, 25 parts of coptis chinensis, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts of erythrina bark and 300 parts of components.
The preparation process of the first herbal medicine component is as follows:
the method comprises the following steps: selecting the following raw materials for later use: 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of Japanese climbing fern vine, 28 parts of common camptotheca bark, 25 parts of coptis root, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts and 300 parts of erythrina bark;
step two: the prepared fructus cnidii 10 parts, the broom cypress fruit saponin Ic15 parts, the tuber fleeceflower stem 15 parts, the cortex ilicis chinensis 28 parts, the coptis chinensis 25 parts, the houttuynia cordata 25 parts, the platycodon grandiflorum 15 parts and the erythrina bark 25 parts are poured into 300 parts of spring water to be soaked for 48 hours, and a solid-liquid mixture A is obtained;
step three: pouring the solid-liquid mixture A prepared in the step two into a decocting pot, decocting the mixture for 1.5 hours with strong fire, pouring out the medicinal liquid to obtain medicinal liquid A, adding 300 parts of spring water into the decocting pot again, and decocting the mixture for 2 hours with strong fire again to obtain medicinal liquid B;
step four: mixing the medicinal liquid A and the medicinal liquid B prepared in the three steps, uniformly stirring, and concentrating for 3 hours to obtain a medicinal liquid A;
step five: filtering the liquid medicine A prepared in the four steps by a 220-mesh filter screen, and filtering out dregs to obtain the Chinese herbal medicine component I.
The second Chinese herbal medicine component consists of 20 parts of matrine, 48 parts of menthol and 30 parts of bisabolol.
The preparation process of the Chinese herbal medicine component II comprises the following steps:
the method comprises the following steps: selecting dried radix Sophorae Flavescentis, pulverizing, extracting, and extracting with ethanol to obtain matrine;
step two: selecting aerial parts of herba Menthae, such as stems, branches, leaves and inflorescences, performing steam distillation to obtain crude oil of herba Menthae, and then obtaining menthol from the crude oil of herba Menthae;
step three: selecting chamomile flowers as raw materials, and extracting bisabolol from the chamomile flowers;
step four: and (3) mixing the matrine and the menthol bisabolol prepared in the first step, the second step and the third step according to the proportion of 20 parts: 48 parts of: pouring 30 parts of the mixture into a stirring kettle, stirring and mixing the mixture, and preparing the Chinese herbal medicine component II after uniformly stirring the mixture.
A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema is prepared by the following steps:
the method comprises the following steps: preparing the following raw materials for later use: PWP 300: 36 parts, olive oil: 50 parts of Chinese herbal medicine component one: 18 parts of Chinese herbal medicine composition II: 18 parts of a mixture;
step two: introducing all the raw materials prepared in the step one into a stirring kettle for stirring, wherein the stirring time is 3 hours, and the rotating speed of the stirring kettle is 500r/min, so as to prepare a raw material finished product;
step three: performing spot inspection on the raw material finished product prepared in the step two, and checking whether the raw material finished product is qualified;
step four: and if the spot inspection in the third step is qualified, packaging and sterilizing the product.
The working principle of the invention is as follows:
when in use, the medicine is directly smeared on the skin and is prepared by adopting green Chinese herbal medicine components without toxicity and side effects, the medicine has broad-spectrum anti-inflammatory and redness-removing and skin barrier repairing effects, meanwhile, the side effects such as immunosuppression and hormone-dependent dermatitis can not be caused after long-term use, compared with the existing medicine, the medicine has better effects when being used for treating dry and itching skin diseases, green and purely natural plant extraction is also suitable for treating infantile eczema, the olive oil is added into the medicine for coordination, the olive oil has the effects of moistening the skin and removing wrinkles, the skin can be smoother and more comfortable, the Chinese herbal medicine component I and the Chinese herbal medicine component II are added, and Chinese herbal medicines with the effects of diminishing inflammation, resisting bacteria, relieving itching, inhibiting inflammation and the like are selected for assistance so as to improve the using effect of the medicine, and the bisabolol is beneficial to improving the penetrability of the ingredients in the medicament, thereby being beneficial to improving the using effect of the medicament.
Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that various changes, modifications, equivalents, improvements and the like can be made therein without departing from the spirit and scope of the invention.
Claims (9)
1. A skin external preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components, characterized in that: the method comprises the following steps:
PWP 300: 18-36 parts;
olive oil: 30-50 parts;
the Chinese herbal medicine comprises the following components: 9-18 parts;
the second Chinese herbal medicine composition: 9-18 parts.
2. The external skin preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components as claimed in claim 1, wherein: the PWP300 is composed of purslane extract, white willow bark extract, peony root bark extract and ferulic acid component.
3. The external skin preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components as claimed in claim 2, wherein: the ratio of the herba portulacae extract, the white willow bark extract, the peony root bark extract and the ferulic acid component is 2:2:2: 1.
4. The external skin preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components as claimed in claim 3, wherein: the preparation process of the PWP300 is as follows:
the method comprises the following steps: selecting fresh stems and leaves of purslane without wormholes, extracting the stems and leaves of the purslane by adopting a low-temperature extraction method to obtain an extract with biological activity, and dissolving the extract in a butanediol solution with a certain concentration to obtain a purslane extract;
step two: selecting weeping willow of fifteen years, taking off tree slices without wormholes from the weeping willow, drying the tree slices, grinding the tree slices after drying, and sieving the tree slices through a 200-mesh sieve after grinding to obtain the white willow bark extract;
step three: selecting root bark of medicinal parts of peony root bark, cortex moutan and salvia miltiorrhiza, cleaning, drying, grinding after drying, and sieving by a 200-mesh sieve to obtain a peony root bark extract;
step four: extracting ferulic acid from cell wall of Ferula plant;
step five: mixing the purslane extract, the white willow bark extract, the peony root bark extract and the ferulic acid obtained in the first step, the second step, the third step and the fourth step according to the ratio of 2:2:2:1, and putting the mixture into a stirring kettle for stirring to obtain the PWP 300.
5. The external skin preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components as claimed in claim 1, wherein: the Chinese herbal medicine component I comprises 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of tuber fleeceflower stem, 28 parts of common camptotheca bark, 25 parts of coptis chinensis, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts of erythrina bark and 300 parts of components.
6. The external skin preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components according to claim 5, which is characterized in that: the preparation process of the herbal medicine component I is as follows:
the method comprises the following steps: selecting the following raw materials for later use: 10 parts of common cnidium fruit, 15 parts of broom cypress fruit saponin Ic, 15 parts of tuber fleeceflower stem, 28 parts of common camptotheca bark, 25 parts of coptis root, 25 parts of heartleaf houttuynia herb, 15 parts of platycodon grandiflorum, 25 parts and 300 parts of erythrina bark;
step two: the prepared fructus cnidii 10 parts, the broom cypress fruit saponin Ic15 parts, the tuber fleeceflower stem 15 parts, the common camptotheca bark 28 parts, the coptis chinensis 25 parts, the houttuynia cordata 25 parts, the platycodon grandiflorum 15 parts and the erythrina bark 25 parts are poured into 300 parts of spring water to be soaked for 48 hours, and a solid-liquid mixture A is obtained;
step three: pouring the solid-liquid mixture A prepared in the step two into a decocting pot, decocting over strong fire for 1.5 hours, pouring out the medicinal liquid to obtain medicinal liquid A, adding 300 parts of spring water into the decocting pot again, and decocting over strong fire for 2 hours again to obtain medicinal liquid B;
step four: mixing the medicinal liquid A and the medicinal liquid B prepared in the three steps, uniformly stirring, and concentrating for 3 hours to obtain a medicinal liquid A;
step five: filtering the liquid medicine A prepared in the four steps by a filter screen of 220 meshes, and filtering out dregs of decoction to obtain the Chinese herbal medicine component I.
7. The external skin preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components as claimed in claim 1, wherein: the second Chinese herbal medicine component consists of 20 parts of matrine, 48 parts of menthol and 30 parts of bisabolol.
8. The external skin preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components as claimed in claim 7, wherein: the preparation process of the Chinese herbal medicine component II comprises the following steps:
the method comprises the following steps: selecting dried radix Sophorae Flavescentis, pulverizing, extracting, and extracting with ethanol to obtain matrine;
step two: selecting aerial parts of herba Menthae, such as stems, branches, leaves and inflorescences, performing steam distillation to obtain crude oil of herba Menthae, and then obtaining menthol from the crude oil of herba Menthae;
step three: selecting chamomile flowers as raw materials, and extracting bisabolol from the chamomile flowers;
step four: and (3) mixing the matrine and the menthol bisabolol prepared in the first step, the second step and the third step according to the proportion of 20 parts: 48 parts of: pouring 30 parts of the mixture into a stirring kettle, stirring and mixing the mixture, and preparing the Chinese herbal medicine component II after uniformly stirring the mixture.
9. The external skin preparation for improving atopic dermatitis and infantile eczema based on PWP300 plant components as claimed in claim 1, wherein: the preparation process comprises the following steps:
the method comprises the following steps: preparing the following raw materials for later use: PWP 300: 18-36 parts of olive oil: 30-50 parts of Chinese herbal medicine component I: 9-18 parts of Chinese herbal medicine composition II: 9-18 parts;
step two: introducing all the raw materials prepared in the step one into a stirring kettle for stirring, wherein the stirring time is 3 hours, and the rotating speed of the stirring kettle is 500r/min, so as to prepare a raw material finished product;
step three: performing spot inspection on the raw material finished product prepared in the step two, and checking whether the raw material finished product is qualified;
step four: and if the spot inspection in the third step is qualified, packaging and sterilizing the product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110234605.7A CN113144037A (en) | 2021-03-03 | 2021-03-03 | A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110234605.7A CN113144037A (en) | 2021-03-03 | 2021-03-03 | A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113144037A true CN113144037A (en) | 2021-07-23 |
Family
ID=76884027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110234605.7A Pending CN113144037A (en) | 2021-03-03 | 2021-03-03 | A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113144037A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617151A (en) * | 2014-10-27 | 2016-06-01 | 周子童 | Powder boiling type traditional Chinese medicine antibacterial and anti-inflammatory agent, preparation method and applications thereof |
| CN106176784A (en) * | 2016-07-18 | 2016-12-07 | 成都爱可依生物科技有限公司 | A kind of pharmaceutical composition for dermatitis, application, preparation and preparation method thereof |
| CN108744016A (en) * | 2018-07-27 | 2018-11-06 | 望江汇通纺织有限公司 | A kind of preparation method of the medical adhesive-bonded fabric dressing of moisture absorption anti-inflammatory |
-
2021
- 2021-03-03 CN CN202110234605.7A patent/CN113144037A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617151A (en) * | 2014-10-27 | 2016-06-01 | 周子童 | Powder boiling type traditional Chinese medicine antibacterial and anti-inflammatory agent, preparation method and applications thereof |
| CN106176784A (en) * | 2016-07-18 | 2016-12-07 | 成都爱可依生物科技有限公司 | A kind of pharmaceutical composition for dermatitis, application, preparation and preparation method thereof |
| CN108744016A (en) * | 2018-07-27 | 2018-11-06 | 望江汇通纺织有限公司 | A kind of preparation method of the medical adhesive-bonded fabric dressing of moisture absorption anti-inflammatory |
Non-Patent Citations (2)
| Title |
|---|
| 崔秀梅，等: "湿疹平治疗血虚风燥型湿疹42例临床研究", 《中国中西医结合皮肤性病学杂志》 * |
| 臧绥平: "浅谈湿疹的中医辨证治疗", 《中外医疗》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104306908A (en) | Health-care composition for preventing respiratory system diseases caused by haze, and preparation method thereof | |
| CN103919711A (en) | Oolong anti-aging whitening cream and preparation method thereof | |
| CN104815191A (en) | Processing method of rhizoma gastrodiae decoction pieces | |
| CN104887563A (en) | Snow chrysanthemum tea anti-allergy mask cream and preparing method thereof | |
| CN104814912A (en) | Hand cream containing camellia oil | |
| CN105078803A (en) | Application of callicarpa plant extract | |
| CN105125470A (en) | Hydrogel microcapsule for oil control and acne removal | |
| CN113730479A (en) | Composition with health care function and preparation method and application thereof | |
| CN102293931B (en) | Traditional Chinese medicinal composition, clinical preparation and preparation methods thereof | |
| CN113144037A (en) | A skin external preparation based on PWP300 plant components for improving atopic dermatitis and infantile eczema | |
| CN101507699B (en) | Chinese herbal medicine cosmetic active composite and preparation method of cosmetic containing the composite | |
| CN106389252A (en) | Health-care rhizome gastrodiae toothpaste | |
| CN103565686A (en) | Permanent plant hair dye and preparation method thereof | |
| CN109771344A (en) | Hormone face remediation composition and preparation method thereof | |
| CN107898749A (en) | A kind of topical composition with skin-care effect and preparation method thereof | |
| CN105558192A (en) | Production method of composite tea made of folium ilicis hainanensis extract and gynostemma pentaphyllum extract | |
| CN107364906B (en) | A kind of environment protection sewage inorganic agent | |
| CN111631966A (en) | Essence for moistening and tendering skin and preparation method thereof | |
| CN111558022A (en) | Foot bath product with blood circulation promoting and uterus warming health care functions and preparation method thereof | |
| CN105616298A (en) | Natural moisturizing skin-care composition and application thereof in cosmetics | |
| CN111700948A (en) | External traditional Chinese medicine for preventing and treating new coronary pneumonia and preparation method thereof | |
| KR20190025863A (en) | Cosmetic or phamaceutical composition comprising herb extract and method for preparing the same | |
| CN111631990A (en) | Vitex negundo repair liquid and preparation method and application thereof | |
| CN115177557B (en) | Jellyfish moisturizing and soothing mask liquid composition and product thereof | |
| KR100987563B1 (en) | External compositions for atopic dermatitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210723 |