CN109453336A - It is a kind of for treating the Chinese medicine composition of wet disease - Google Patents

It is a kind of for treating the Chinese medicine composition of wet disease Download PDF

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CN109453336A
CN109453336A CN201811203131.4A CN201811203131A CN109453336A CN 109453336 A CN109453336 A CN 109453336A CN 201811203131 A CN201811203131 A CN 201811203131A CN 109453336 A CN109453336 A CN 109453336A
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chinese medicine
medicine composition
radix
weight
chinese
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吴蓓莉
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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    • A61K36/06—Fungi, e.g. yeasts
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Abstract

The present invention provides a kind of for treating the Chinese medicine composition of wet disease, the Chinese medicine composition is exterior-applied formulation, the Chinese medicine composition includes following traditional Chinese medicinal components: cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, radix scutellariae, the root bark of tree peony, poria cocos, rhizoma alismatis, kuh-seng, the coptis, Cortex Phellodendri, Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, Cortex Magnoliae Officinalis, cortex dictamni, curcuma zedoary, Caulis Spatholobi, tuber fleeceflower stem, radix paeoniae rubra, smilax, the fleece-flower root and Radix Rehmanniae, the Chinese medicine composition is invigorated blood circulation with inducing diaphoresis, it is clearing heat and detoxicating, expelling wind and clearing away cold, heat-clearing and damp-drying drug, the effect of strengthening the spleen and replenishing qi, wet disease can effectively be treated.

Description

It is a kind of for treating the Chinese medicine composition of wet disease
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of for treating the Chinese medicine composition of wet disease.
Background technique
Wet disease is a kind of common allergic inflammation dermatoses.It is symmetrical, violent itch, anti-with fash diversity Recurrence is made, easily evolves into chronic be characterized.Can betide any age, any position, any season, but often in winter recurrence or Aggravation.Wet disease clinical symptoms change multiterminal show difference according to the skin lesion in pathogenic process, are divided into acute, subacute and chronic Three types.The damage pleomorphism of acute wet disease, initial stage are erythema, conscious scorching hot, itch.Followed by occur being dispersed in erythema or After intensive papule or phlysis, scratching or friction, scratches and form rotten to the corn, sepage face.With the passing of time or treatment after acute inflammation Mitigate, skin lesion drying, incrustation, the scales of skin that peel off, and enters subacute stage.
The generation of wet disease, Chinese medicine think inside and outside because having it concurrently, internal cause mainly with constitution, feelings will, the dirty functional disturbance of internal organs It is related；External cause mainly to exogenous disease wind, wet, heat evil and improper diet related.The wet disease interpretation of the cause, onset and process of an illness can be summarized as exopathogen attack table, it is damp and hot in Accumulate, the dry wind victory of blood, spleen asthenia and dampness retention.
Summary of the invention
For treating the Chinese medicine composition of wet disease, toxic side effect is small the technical problem to be solved in the present invention is to provide a kind of, Wet disease can effectively be treated.
In order to solve the above-mentioned technical problems, the present invention provides a kind of for treating the Chinese medicine composition of wet disease, feature Be, the Chinese medicine composition includes following traditional Chinese medicinal components: cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix cyathulae, dried lacquer, the root of Chinese clematis, radix scutellariae, the root bark of tree peony, poria cocos, rhizoma alismatis, kuh-seng, the coptis, Cortex Phellodendri, Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, Cortex Magnoliae Officinalis, shaggy-fruited dittany Skin, curcuma zedoary, Caulis Spatholobi, tuber fleeceflower stem, radix paeoniae rubra, smilax, the fleece-flower root and Radix Rehmanniae.
The Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight in one of the embodiments:
The Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight in one of the embodiments:
The Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight in one of the embodiments:
In one of the embodiments, the Chinese medicine composition be exterior-applied formulation, the exterior-applied formulation include by patch, Any one of paint and liniment dosage form, application position are disease affected part.
The traditional Chinese medicinal components that the Chinese medicine composition includes in one of the embodiments, are corresponding Chinese medicine raw medicine point The Chinese medical extract not obtained through supercritical CO_2 extraction.
The Chinese medicine composition further includes medicinal material and pharmaceutically acceptable auxiliary material in one of the embodiments, described Auxiliary material includes gelling agent, moisturizer, preservative, antioxidant, emulsifier, thickener, any one in skin penetration enhancer Or it is several.
The Chinese medicine composition is paint in one of the embodiments,.
The auxiliary material includes gelling agent in one of the embodiments, and the gelling agent includes that xanthan gum and carboxymethyl are fine The weight ratio of the plain sodium of dimension, the xanthan gum and the sodium carboxymethylcellulose is 10:1~1:1.
The auxiliary material includes moisturizer in one of the embodiments, the moisturizer be glycerol, the glycerol with it is described The weight ratio of gelling agent is 10:1~4:1.
The technical effects of the invention are that: it is provided by the invention a kind of for treating the Chinese medicine composition of wet disease, there is solution The effect of removing toxic substances of table activating blood and clearing heat, expelling wind and clearing away cold, heat-clearing and damp-drying drug, strengthening the spleen and replenishing qi, it can effectively treat wet disease；The present invention simultaneously Chinese medicine composition topical administration, directly acts on lesion, and effect faster, and to human body Small side effects, effectively mitigates patient's pain.
Specific embodiment
The present invention is further explained in the light of specific embodiments, so that those skilled in the art can be better Understand the present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
The present invention provides a kind of for treating the Chinese medicine composition of wet disease, and the Chinese medicine composition is exterior-applied formulation, institute Stating Chinese medicine composition includes following traditional Chinese medicinal components: cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, Dried lacquer, the root of Chinese clematis, radix scutellariae, the root bark of tree peony, poria cocos, rhizoma alismatis, kuh-seng, the coptis, Cortex Phellodendri, Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, Cortex Magnoliae Officinalis, cortex dictamni, curcuma zedoary, Caulis Spatholobi, tuber fleeceflower stem, radix paeoniae rubra, smilax, the fleece-flower root and Radix Rehmanniae.
Wherein, cimicifugae foetidae, which has, delivers promoting eruption, clearing heat and detoxicating, the effect of lifting disease.It is analyzed through modern technologies, it is main containing liter Snippings stem is containing cimicifugine, salicylic acid, tannin, resin, caffeic acid, ferulic acid, isoferulic acid, cimicifugoside, cimigenol xyloside etc. Ingredient.
Rhizoma Et Radix Notopterygii is warm-natured, acrid flavour is bitter, enters bladder, kidney channel, has the function of scattered exterior cold, wind-damp dispelling, sharp joint.Through modern medicine Analysis.Rhizoma Et Radix Notopterygii ingredient is volatile oil and cumarin.
Radix Angelicae Pubescentis has the function of wind-dispelling, wins wet, cold dispelling, analgesic.It is analyzed through modern technologies, mainly contains bitter scholar's Coumarins Compound, columbianetin and its caproate, osthole, different imperatorin, bergapten, xanthotoxin, dihydro mountain The ingredients such as celery alcohol angelate, columbianetin glycoside, Angelica pubescens alcohol, angelol, γ-aminobutyric acid and volatile oil.
The root of Dahurain angelica has wind-damp dispelling, apocenosis of invigorating blood circulation, the effect of myogenic pain relieving.It is analyzed through modern technologies, mainly contains volatile oil, it is fragrant Legumin and its derivative, such as angelicin, Bai Danggui ether, Imperatoria ostruthium B prime, angelicotoxin.Also contain volatile oil, has 3- in oil The ingredients such as methylene -6- cyclohexene, 11 charcoal alkene -4, elemene, hexadecanoic acid, nonenol.
Ramulus cinnamomi has the function of sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi.It is analyzed through modern technologies, mainly contains volatile oil, volatile oil Ingredient has cinnaldehydrum, Ergol, cinnamyl acetate, β-cadinene, Chang Pu's alkene, coumarin etc..
The effect of Chinese ephedra has inducing sweat and dispelling exogenous evils, freeings lung and relieving asthma, inducing diuresis for removing edema.Through modern medical analysis, main component is more Kind alkaloid, such as ephedrine, d-pseudo-ephedrine, ephedine, separately contain volatile oil, flavone compound etc..
Radix Salviae Miltiorrhizae has the function of promoting blood circulation, calming heart and tranquilizing mind, apocenosis, analgesic.It is analyzed through modern technologies, mainly contains Radix Salviae Miltiorrhizae The ingredients such as ketone, isotanshinone, Cryptotanshinone, different Cryptotanshinone, methyltanshinone, hydroxyl tanshinone.
Rhizoma Chuanxiong has the function of that promote breath and open depression, method wind-dryness be wet, promoting blood circulation and stopping pain.It is analyzed through modern technologies, mainly contains Rhizoma Chuanxiong Piperazine, loline, Ligustilide, Rhizoma Chuanxiong naphthalene furan lactone, 3- butylidenephthalide, 3- butylidene -7- hydroxyl phthalide, butylphthalide, (3S) -3- normal-butyl -4- hydroxyl phthalide, 3- normal-butyl -3,6,7- trihydroxy -4,5,6,7- tetrahydro phthalides, new ligustilide, Senkyunolide, foreign Rhizoma Chuanxiong quinone, 2- methoxyl group -4- (3- methoxyl group -1- acrylic) phenol, 2- valeryl-benzene methyl, 4- hydroxyl Base -3- methoxybenzene alkene, 4-HBA, vanillic acid, caffeic acid, protocatechuic acid, ferulic acid, Chrysophanol, sedanonic acid, L- isoleucyl--Valine acid anhydride, L- valyl-Valine acid anhydride, loline, chuanxingol, urea pyrimidine, trimethylamine hydrochloride, Choline chloride, palmitinic acid, vanillic aldehyde, 1- acyl-B-carboline, spainulenol, cupreol, dilinoleic acid tripalmitin Equal ingredients.
Radix cyathulae has the function of diuresis of blood circulation promoting.Through modern medical analysis, mainly look for the ketone that continues containing cup, 5- table cup look for stay ketone, Headdress flower cup, which is look at, stays ketone, dish of looking to stay beautiful, decortication that heir, beet is stayed to cry out.
Dried lacquer plays the role of broken silt, disperse accumulation.Through modern medical analysis, dried lacquer is effect of the laccol in raw lacquer in laccase Under, the black resin shape substance of generation is aoxidized in air.
The root of Chinese clematis has the function of wind-damp dispelling, degrading the channel, dissolving phlegm saliva, dissipating the hypochondriac lump.It is analyzed through modern technologies, mainly contains original Anemonin often sees rattan sapogenin, table hederagenin, oleanolic acid, the root of Chinese clematis -23-O- arabinose saponin, Wheeling Celestial monosaccharide saponin, root of Chinese clematis disaccharides saponin, root of Chinese clematis trisaccharide saponin, root of Chinese clematis tetrose saponin, root of Chinese clematis pentasaccharides saponin, Cheng Ling The ingredients such as celestial being -23-O- glucose saponin.
Radix scutellariae has effects that restrain calmness, diuresis, Hepatoprotective cholagogue.Through modern medical analysis, main component includes Huang Ketone, tannin, baicalin etc..
The root bark of tree peony has the function of clearing heat and cooling blood, promoting blood circulation to remove blood stasis, enters ying blood, febrile virulent maculae, night fever abating at dawn, lossless bone for heat Steaming, amenorrhea and algomenorrhea, the pain of injury caused by falling and tumbling, carbuncle sore tumefacting virus.Through modern medical analysis, main component includes paeonol, and paeonoside is male Red phenol original glycosides and the new glycosides of paeonol also contain Paeoniflorin, oxypaeoniflorin, benzoylpaeoniflorin, hydroxypaeoniflorin, benzoxy Change Paeoniflorin and tannin etc..
Poria cocos has effects that row water, dampness removing heat.Through modern medical analysis, poria cocos main component include pachymic acid, Pachymic acid methyl esters, 16 Alpha-hydroxy eburicoic acid methyl esters, total triterpenes methyl esters, 3- hydrogenate loose Siberian cocklebur acid, eburicoic acid, dehydroeburicoic acid, Fu Siberian cocklebur eo-acid, pachyman, ergosterol, hendecanoic acid, lauric acid, lauric acid ester, palmitinic acid, dodecylene acid esters and octanoic acid Equal ingredients.
Rhizoma alismatis has effects that diuresis heat-clearing.Through modern medical analysis, main component includes rhizoma alismatis containing a variety of Fourth Rings three Terpene acetol derivative alisol A, B, C and its acetic acid esters, epialisol A, alismoxide, lecithin, choline, furfural, biology Alkali, resin, asparagine etc., and the alcohol of kind containing rhizoma alismatis, rhizoma alismatis glycosides, big Mang bicyclogermacrene, rheum emodin, cupreol and its stearate Deng.
Kuh-seng has effects that heat-clearing and damp-drying drug, wind dispelling insecticide, main damp-heat dysentery, hematochezia, jaundice, difficult urination, water Swollen, pruritus vulvae, scabies, leprosy, pruitus and wet poison sore.Through modern medical analysis, kuh-seng main component includes matrine, oxygen Change matrine, N- oxidation sophocarpine, Sophoridine, the other matrine of dextrorotation, dextrorotation Iosmatrine, dextrorotation sophoranl, left-handed sophocarpine, Left-handed sophoramine, dextrorotation-N-Methylcytisine, left-handed anagyrine, bap-iifoline, kuh-seng saponin and a variety of flavonoids Object, including the new alcohol of kuh-seng, kuh-seng chalcone, kuh-seng chalcone alcohol.
The coptis has the function of purging intense heat, eliminating dampness, removing toxic substances, desinsection.It is analyzed through modern technologies, mainly contains jamaicin, the coptis The ingredients such as alkali, worenine, palm leaf coculine, jateorrhizine, obakunone, obakulactone.
Cortex Phellodendri has the function of heat-clearing.It is analyzed through modern technologies, mainly contains jamaicin, jateorrhizine, magnoflorine, Cortex Phellodendri Alkali, candicine, palmatine, Dauricine, obakunone, obakulactone, Dictamnolide, obacunonic acid, green firefly The ingredients such as light acid, 7- dehydrogenation stigmasterol, cupreol, campesterol.
Rhizoma Atractylodis Macrocephalae has the effectiveness of strengthening the spleen and replenishing qi and eliminate dampness and have diuretic effect.Through modern medical analysis, α-and β-humulus grass are mainly contained Alkene, β-elemol, α curcumene, atractylone, 3 β-acetoxyl group atractylone, celery dienone, eucalyptol, palmitinic acid, hinesol, β-selinene and sesquiterpene lactone, including atractyloide-I ,-II ,-III and 8 β-ethyoxyl atractyloide-II, The trans- Rhizoma Atractylodis Macrocephalae triol of each inner smooth acyl group -8- of the cis- reefing triol of 14- acetyl group -12- climbing groundsel acyl group -8-, 14- acetyl group, 12- The cis- Rhizoma Atractylodis Macrocephalae triol of climbing groundsel light acyl group -8-, the trans- Rhizoma Atractylodis Macrocephalae triol of 12- climbing groundsel acyl group -8-, 12 Alpha-Methyl bytyry -14- second The cis- Rhizoma Atractylodis Macrocephalae triol of acyl group -8-, the trans- Rhizoma Atractylodis Macrocephalae triol of 12 Alpha-Methyl bytyry -14- acetyl group -8-, 14 Alpha-Methyl bytyry -8- Cis- Rhizoma Atractylodis Macrocephalae triol, the trans- Rhizoma Atractylodis Macrocephalae triol of 14 Alpha-Methyl bytyry -8-, Scopoletin and the immunocompetent mannosan of tool etc. at Point.
Rhizoma atractylodis have effects that drying damp and strengthening spleen, expelling wind and clearing away cold.Through modern medical analysis, rhizoma atractylodis main component be atractylol, Atractylone, alditol and volatile oil, the main component of volatile oil are hinesol, sagittol etc..
Cortex Magnoliae Officinalis has eliminating dampness dissolving phlegm, the effect of lower gas removes full, in humidity hysteresis wound, abdominal swelling and diarrhea, stagnation of QI due to dyspepsia, abdominal distension just Secret, sputum cough.Through modern medical analysis, main component be magnolol, honokiol, the new phenol of magnolia obovata, 6 '-O- methyl and Magnolol, Cortex Magnoliae Officinalis aldehyde, Taiwan sassafrases aldehyde, peppery menthyl magnolol, double peppery menthyl magnolols, peppery menthyl honokiol, dragon Born of the same parents' base magnolol, magnocurarine and salicifoline etc..
Cortex dictamni have dispel pathogenic wind and remove dampness, clearing heat and detoxicating effect, control wind-heat sore, scabies, itchy skin eruption, rheumatic arthralgia, Jaundice.Through modern medical analysis, main component includes containing psoralen, xanthotoxin, Scopoletin, Quercetin, isoquercitrin Element, dictamine, γ-fagarine, preceding skimmianine, skimmianine, dasycarpamin, trigonelline, choline, O- ethyl-drop-dictamine, Evodine, shaggy-fruited dittany alcohol, pregnene acid ketone, fraxinellon, obakunone, limonin, cupreol, Lay oil sterol and saponin Deng.
The effect of curcuma zedoary promoting the circulation of qi blood-breaking and clearing stagnation and killing pain.Through modern medical analysis, the main ketenes of furans containing curcuma zedoary, borneol, Nopinene, lauro lene, limonene, terpinene, isoborneol, cloves alkene, curcumene, cloves alkene epoxides, turmerone, fragrant turmeric The ingredients such as ketone, curdione and Curcumenol, isocurcumenol.
Caulis Spatholobi has the effect of activating blood and relaxing tendons, nourishing blood for regulating menstruation.Through modern medical analysis, mainly contain freidelin, 3 β-nothing Bridle terpene alcohol, taraxerol, campesterol, stigmasterol and sitosterol etc..
Tuber fleeceflower stem has effects that mental-tranquilization, wind-dispelling, dredging collateral.Main insomnia, dreaminess, deficiency of blood bodily pain, numbness, rheumatism Numbness pain, rubella itch.Through modern medical analysis, main component includes Anthraquinones, predominantly rheum emodin, Chrysophanol or rheum emodin Methyl ether, also contains anthraquinone analog compound, Physcion, rheum emodin -8-O-5-O- xyloside, β-at luteolin -5-O- xyloside Sitosterol and tannin.
Radix paeoniae rubra has effects that stasis eliminatings analgesic, cool blood detumescence.Through modern medical analysis, radix paeoniae rubra main component be Paeoniflorin, Oxidized paeoniflorin glycosides, benzoylpaeoniflorin, albiflorin, Paeoniflorin are without ketone, nutgall acyl Paeoniflorin, β-pinane -10- alkenyl-β-common vetch Glucoside, lactiflorin and paeonilactone A, B, C, cupreol, Daucosterol and volatile oil, volatile oil are mainly benzoic acid and male Red phenol.
Smilax has effects that removing toxic substances dehumidifying.Through modern medical analysis, main component includes astilbin, different astragalus The ingredients such as glycosides, daucosterol, succinic acid, matter of mixing, flavones, cupreol.
The fleece-flower root has the function of active blood-nourishing, strengthening the bones and muscles, nourishing liver and kidney.Through modern medical analysis, mainly contain containing anthraquinone Class compound, including rheum emodin, Chrysophanol and Physcion, Rhein, chrysophanic acid anthrone；Contain stilbene compound, packet again Include resveratrol, piceid, 2,3,5,4 '-tetrahydroxy Stilbene -2-O-D- glycosides, 2,3,5,4'- tetrahydroxy hexichol second Alkene -2-O- β-D-Glucose glycosides -2 "-O- gallate, 2,3,5,4 '-tetrahydroxystilbene -2-O- glycosides -3 "-O- is not eaten Sub- acid esters, gallic acid, dextrorotation cachou extract, 3-O- nutgall acyl-cachou extract, 3-O- nutgall acyl original Cyanidin B-2, β- Sitosterol and lecithin etc..
Radix Rehmanniae has effects that clearing heat and cooling blood, promotes the production of body fluid.Through modern medical analysis, main component includes alcohol, glutinous rehmannia purple sieve The ingredients such as blue glycosides, glutinous rehmannia hardship glycosides, rehmanin, glutinous rehmannia glycan, Dihuang polysaccharide, palmitinic acid and amino acid.
Above-mentioned Chinese medicine composition provided by the invention, through treated in vitro, according to theory of traditional Chinese medical science, each ingredient is made according to corresponding With that can be divided into four kinds of classification of drug of monarch, collaboration plays a role, and adjusts the pharmacological property of various Chinese medicines, there is inducing diaphoresis to invigorate blood circulation, The effect of clearing heat and detoxicating, expelling wind and clearing away cold, heat-clearing and damp-drying drug, strengthening the spleen and replenishing qi, can effectively treat wet disease.
Further, according to the present invention in Chinese medicine composition each traditional Chinese medicinal components monarch in the composition significance level And the severity for different disease sites, the embodiment of an above-mentioned Chinese medicine composition provided by the invention, the implementation The Chinese medicine composition of mode includes the traditional Chinese medicinal components of following parts by weight: 8~18 parts by weight of cimicifugae foetidae；4~15 parts by weight of Rhizoma Et Radix Notopterygii； 8~18 parts by weight of Radix Angelicae Pubescentis；8~18 parts by weight of the root of Dahurain angelica；4~15 parts by weight of ramulus cinnamomi；4~15 parts by weight of Chinese ephedra；4~15 weight of Radix Salviae Miltiorrhizae Measure part；10~20 parts by weight of Rhizoma Chuanxiong；4~15 parts by weight of radix cyathulae；3~10 parts by weight of dried lacquer；12~25 parts by weight of the root of Chinese clematis； 8~18 parts by weight of radix scutellariae；12~25 parts by weight of the root bark of tree peony；8~18 parts by weight of poria cocos；4~15 parts by weight of rhizoma alismatis；Kuh-seng 12~ 25 parts by weight；12~25 parts by weight of the coptis；8~18 parts by weight of Cortex Phellodendri；10~20 parts by weight of Rhizoma Atractylodis Macrocephalae；8~18 parts by weight of rhizoma atractylodis； 4~15 parts by weight of Cortex Magnoliae Officinalis；12~25 parts by weight of cortex dictamni；8~18 parts by weight of curcuma zedoary；4~15 parts by weight of Caulis Spatholobi；Tuber fleeceflower stem 8 ~18 parts by weight；4~15 parts by weight of radix paeoniae rubra；10~20 parts by weight of smilax；4~15 weight of 4~15 parts by weight of the fleece-flower root and Radix Rehmanniae Measure part.
Further, the Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight: 10~15 weight of cimicifugae foetidae Part；6~12 parts by weight of Rhizoma Et Radix Notopterygii；10~15 parts by weight of Radix Angelicae Pubescentis；10~15 parts by weight of the root of Dahurain angelica；6~12 parts by weight of ramulus cinnamomi；Chinese ephedra 6~ 12 parts by weight；6~12 parts by weight of Radix Salviae Miltiorrhizae；12~18 parts by weight of Rhizoma Chuanxiong；6~12 parts by weight of radix cyathulae；5~9 parts by weight of dried lacquer； 15~21 parts by weight of the root of Chinese clematis；10~15 parts by weight of radix scutellariae；15~21 parts by weight of the root bark of tree peony；10~15 parts by weight of poria cocos；Rhizoma alismatis 6~12 parts by weight；15~21 parts by weight of kuh-seng；15~21 parts by weight of the coptis；10~15 parts by weight of Cortex Phellodendri；12~18 weight of Rhizoma Atractylodis Macrocephalae Measure part；10~15 parts by weight of rhizoma atractylodis；6~12 parts by weight of Cortex Magnoliae Officinalis；15~21 parts by weight of cortex dictamni；10~15 parts by weight of curcuma zedoary；Chicken 6~12 parts by weight of blood rattan；10~15 parts by weight of tuber fleeceflower stem；6~12 parts by weight of radix paeoniae rubra；12~18 parts by weight of smilax；The fleece-flower root 6 6~12 parts by weight of~12 parts by weight and Radix Rehmanniae.
Further, the Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight: 12 parts by weight of cimicifugae foetidae；Rhizoma Et Radix Notopterygii 9 parts by weight；12 parts by weight of Radix Angelicae Pubescentis；12 parts by weight of the root of Dahurain angelica；9 parts by weight of ramulus cinnamomi；9 parts by weight of Chinese ephedra；9 parts by weight of Radix Salviae Miltiorrhizae；Rhizoma Chuanxiong 15 Parts by weight；9 parts by weight of radix cyathulae；6 parts by weight of dried lacquer；18 parts by weight of the root of Chinese clematis；12 parts by weight of radix scutellariae；18 parts by weight of the root bark of tree peony；It is red 12 parts by weight of Poria cocos；9 parts by weight of rhizoma alismatis；18 parts by weight of kuh-seng；18 parts by weight of the coptis；12 parts by weight of Cortex Phellodendri；15 weight of Rhizoma Atractylodis Macrocephalae Part；12 parts by weight of rhizoma atractylodis；9 parts by weight of Cortex Magnoliae Officinalis；18 parts by weight of cortex dictamni；12 parts by weight of curcuma zedoary；9 parts by weight of Caulis Spatholobi；Tuber fleeceflower stem 12 parts by weight；10 parts by weight of radix paeoniae rubra；15 parts by weight of smilax；10 parts by weight of 9 parts by weight of the fleece-flower root and Radix Rehmanniae.
As an alternative embodiment, provided by the present invention for the exterior-applied formulation for the Chinese medicine composition for treating wet disease Including any one of patch, paint and liniment, application position is disease affected part.The medicament of the wet disease of traditional treatment mostly uses mouth Clothes, and in the present invention, patient is directly granted without oral drugs, does not take orally important sense of discomfort, while is quick, and poison is secondary to be made With small.
The traditional Chinese medicinal components that Chinese medicine composition provided by the present invention for treating wet disease includes are corresponding Chinese medicine raw medicine point Not through supercritical CO2Extract the Chinese medical extract obtained.Compared to traditionally, medicinal material is used as medicine by decocting for patch or soup Agent, the traditional Chinese medicinal components of Chinese medicine composition of the invention are that medicinal material passes through supercritical CO respectively2It extracting, active constituent content is high, and And pass through supercritical CO2The traditional Chinese medicinal components of extraction are unfavorable for the material composition of drug absorption, substantially increase the Chinese medicine Furthermore the efficiency of composition percutaneous absorbtion also reduces the dosage that Chinese medicine composition is applied to affected part, avoid topical agent use It measures excessive to patient's bring sense of discomfort.
One embodiment of the invention further includes medicinal material and pharmaceutically acceptable auxiliary for treating the Chinese medicine composition of wet disease Material, auxiliary material includes gelling agent, moisturizer, preservative, antioxidant, emulsifier, thickener, any one in skin penetration enhancer Kind is several.Chinese medicine composition for treating wet disease of the invention can improve the Chinese medicine group by adding suitable auxiliary material Close the formulation characteristic of object.For example, gel preparations can be provided by adding gelling agent.For another example, it can be kept away by adding moisturizer The Chinese medicine composition for exempting to be attached to skin is dry, sense of discomfort caused by avoiding pharmaceutical composition dry in skin surface.For another example, lead to Spend the pot-life that the Chinese medicine composition can be appropriately extended in addition preservative.
Further optionally, the exterior-applied formulation of an embodiment of the present invention is paint.
Optionally, auxiliary material includes gelling agent, which includes xanthan gum and sodium carboxymethylcellulose, xanthan gum and carboxylic first The weight ratio of base sodium cellulosate is 10:1~1:1.In the Chinese medicine composition in use, Chinese medicine composition can be in the work of gelling agent With lower sustained release in affected part, extends the drug effect of the Chinese medicine composition, reduce dressing change frequency, used convenient for patient.Further, it coagulates Jelly includes xanthan gum that weight ratio is 10:1~1:1 in sodium carboxymethylcellulose, the property such as the gelling agent viscosity of formation, mobility It can be adapted to Chinese medicine composition.
Still optionally further, moisturizer is glycerol, and the weight ratio of glycerol and gelling agent is 10:1~4:1.By making conduct The glycerol of moisturizer and the total amount ratio of gelling agent are 10:1~4:1, are formed after glycerol and gelling agent can be made to interact good The g., jelly-like form of sense of touch improves comfort level when patient uses.
The traditional Chinese medicinal components of the Chinese medicine composition for treating wet disease of following embodiment of the present invention, select commercially available medicinal material liter Fiber crops, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, radix scutellariae, the root bark of tree peony, poria cocos, pool It rushes down, kuh-seng, the coptis, Cortex Phellodendri, Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, Cortex Magnoliae Officinalis, cortex dictamni, curcuma zedoary, Caulis Spatholobi, tuber fleeceflower stem, radix paeoniae rubra, smilax, the fleece-flower root And Radix Rehmanniae, it is obtained respectively through supercritical CO_2 extraction.
The preparation method of the Chinese medicine composition for treating wet disease of following embodiment of the present invention is as follows, weighs formula respectively The traditional Chinese medicinal components and auxiliary material of amount are prepared into the Chinese medicine group for being used to treat wet disease of the dosage form according to the preparation method of corresponding dosage form Close object.It should be noted that in the examples below, mainly providing exterior-applied formulation includes liniment and paint, and application dosage form is not The drug effect that will affect the Chinese medicine composition for being used to treat wet disease is administered the only possible speeds for influencing drug effects and playing of difference of dosage form And the degree of convenience that uses of user and comfort level.
Clinic chooses 50 wet disease patients as experimental group, is divided into five groups according to illness weight situation, every group 10, applies With the Chinese medicine composition in Examples 1 to 5, daily medication twice, continuous use two weeks；Optionally take 10 as a control group, And control group and experimental group patient body situation, age situation are similar with disease condition, and control group is not administered during test.
Criterion of therapeutical effect:
Cure: skin lesion restores normal, does not itch, or have slight gargalesthesia.
Effective: 70% skin lesion restores normal, and remaining skin lesion gradually improves, with slight itch.
Improve: 30% skin lesion restores normal, and remaining skin lesion has plump or few liquid exudation, with scratchiness, but Shang Nengren By.
Invalid: local skin lesion is less than improvement standard, or without improvement, or even deteriorates.
Treatment results are shown: in 50 patients of experimental group, being cured 24, effective 12, improved 8, invalid 6, always have Efficiency 88%；In control group, 0 is cured, effective 0, is improved 1, no effect 9, total effective rate 10%.
Conclusion: the Chinese medicine composition is significant in efficacy.
Clinic chooses 20 wet disease patients, is divided into the first and second two groups and two groups of patient ages, physical conditions are similar, apply respectively With the Chinese medicine composition in embodiment 3 and embodiment 6, daily medication twice, continuous use two weeks.Treatment results show first group 5 are cured, effective 3, is improved 1, invalid 1；Second group cures 4, effective 4, improves 1, invalid 1.Treatment results No significant difference.Therefore curative effect is unrelated with form of Chinese drug.
Embodiment described above is only to absolutely prove preferred embodiment that is of the invention and being lifted, protection model of the invention It encloses without being limited thereto.Those skilled in the art's made equivalent substitute or transformation on the basis of the present invention, in the present invention Protection scope within.Protection scope of the present invention is subject to claims.

Claims (10)

1. a kind of for treating the Chinese medicine composition of wet disease, which is characterized in that the Chinese medicine composition includes following traditional Chinese medicinal components: Cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, radix scutellariae, the root bark of tree peony, poria cocos, Rhizoma alismatis, kuh-seng, the coptis, Cortex Phellodendri, Rhizoma Atractylodis Macrocephalae, rhizoma atractylodis, Cortex Magnoliae Officinalis, cortex dictamni, radix cyathulae, curcuma zedoary, Caulis Spatholobi, tuber fleeceflower stem, radix paeoniae rubra, soil Fu Siberian cocklebur, the fleece-flower root and Radix Rehmanniae.
2. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition includes following parts by weight Traditional Chinese medicinal components:
3. Chinese medicine composition according to claim 2, which is characterized in that the Chinese medicine composition includes following parts by weight； Several traditional Chinese medicinal components:
4. Chinese medicine composition according to claim 3, which is characterized in that the Chinese medicine composition includes following parts by weight； Several traditional Chinese medicinal components:
5. Chinese medicine composition according to any one of claims 1 to 4, which is characterized in that the Chinese medicine composition is outer With dosage form, the exterior-applied formulation includes any one application dosage form of patch, paint and liniment, and application position is patient's sufferer Place.
6. Chinese medicine composition according to claim 5, which is characterized in that the Chinese medicine group that the Chinese medicine composition includes It is divided into the Chinese medical extract that corresponding Chinese medicine raw medicine is obtained through supercritical CO_2 extraction respectively.
7. Chinese medicine composition according to claim 6, which is characterized in that the Chinese medicine composition further includes medicinal material and medicine Acceptable auxiliary material is learned, the auxiliary material includes gelling agent, moisturizer, preservative, antioxidant, emulsifier, thickener, Transdermal absorption Any one or a few in promotor.
8. Chinese medicine composition according to claim 7, which is characterized in that the Chinese medicine composition is paint.
9. Chinese medicine composition according to claim 7, which is characterized in that the auxiliary material includes gelling agent, the gelling agent Including xanthan gum and sodium carboxymethylcellulose, the weight ratio of the xanthan gum and the sodium carboxymethylcellulose is 10:1~1:1.
10. Chinese medicine composition according to claim 7, which is characterized in that the auxiliary material includes moisturizer, the moisturizer For glycerol, the weight ratio of the glycerol and the gelling agent is 10:1~4:1.
CN201811203131.4A 2018-10-16 2018-10-16 It is a kind of for treating the Chinese medicine composition of wet disease Pending CN109453336A (en)

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Application publication date: 20190312