CN109453347A - It is a kind of for treating the Chinese medicine composition of kidney - Google Patents

It is a kind of for treating the Chinese medicine composition of kidney Download PDF

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CN109453347A
CN109453347A CN201811203142.2A CN201811203142A CN109453347A CN 109453347 A CN109453347 A CN 109453347A CN 201811203142 A CN201811203142 A CN 201811203142A CN 109453347 A CN109453347 A CN 109453347A
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chinese medicine
medicine composition
radix
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吴蓓莉
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/06—Fungi, e.g. yeasts
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Abstract

The invention discloses a kind of for treating the Chinese medicine composition of kidney, which is exterior-applied formulation.The Chinese medicine composition includes following traditional Chinese medicinal components: cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, evodia rutaecarpa, rhizoma zingiberis, wide perfume, cortex cinnamomi, Radix Astragali, monkshood, psoralea corylifolia, poria cocos, turmeric, Radix Codonopsis, Herba Cistanches, Poria cocos, Radix Glycyrrhizae, monkshood, Rhizoma Atractylodis Macrocephalae, asarum, radix rehmanniae preparata, radix saposhnikoviae and rhizoma atractylodis, the Chinese medicine composition has the function of kidney-nourishing qi-restoratives, activating microcirculation and removing stasis medicinal, removes obstruction in channels to relieve pain, blood-enrich and clearing heat and detoxicating, can effectively treat kidney.

Description

It is a kind of for treating the Chinese medicine composition of kidney
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of for treating the Chinese medicine composition of kidney.
Background technique
Kidney is common one of the tumour of urinary system, accounts for about 2% one the 3% of whole body malignant tumour, it is fallen ill in recent years Rate is in rising trend, and most patients with renal cell carcinoma have been advanced stages when medical, and rehabilitation is difficult, has been to threaten human life and health One big killer.
Modern Western medicine treatment tumour mostly uses chemotherapy or radiation therapy, while killing cancer cell, is also permitted human body More normal cells are eliminated together, have very big side effect, while cure rate is low, bring huge pain and psychology to press to patient Power.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of for treating the Chinese medicine composition of kidney, can effectively treat kidney Cancer and conditioning engine body improve conditions of patients and reduce patient suffering.
In order to solve the above-mentioned technical problem, a kind of for treating the Chinese medicine composition of kidney, which is characterized in that the Chinese medicine Composition includes following traditional Chinese medicinal components: cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, prestige It is medicine xiaolingxian, evodia rutaecarpa, rhizoma zingiberis, wide perfume, cortex cinnamomi, Radix Astragali, monkshood, psoralea corylifolia, poria cocos, turmeric, Radix Codonopsis, Herba Cistanches, Poria cocos, sweet Grass, monkshood, Rhizoma Atractylodis Macrocephalae, asarum, radix rehmanniae preparata, radix saposhnikoviae and rhizoma atractylodis.
Further, the Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight:
Further, the Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight:
Further, the Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight:
Further, the Chinese medicine composition is exterior-applied formulation, and the exterior-applied formulation includes by immersion, attaches, spraying And any one insecticide-applying way in sprinkling is that the Chinese medicine composition is applied to patient's waist kidney area and renal cancer tumor turn Move position.
Further, the traditional Chinese medicinal components that the Chinese medicine composition includes are corresponding Chinese medicine raw medicine respectively through overcritical CO2Extract the Chinese medical extract obtained.
Further, the Chinese medicine composition further includes medicinal material and pharmaceutically acceptable auxiliary material, and the auxiliary material includes solidifying Jelly, moisturizer, preservative, antioxidant, emulsifier, thickener, any one or a few in skin penetration enhancer.
Further, the exterior-applied formulation be patch, the Chinese medicine composition mixed with the auxiliary material be attached to papery or On cloth substrate.
Further, the auxiliary material includes gelling agent, and the gelling agent includes xanthan gum and sodium carboxymethylcellulose, described The weight ratio of xanthan gum and the sodium carboxymethylcellulose is 10:1~1:1.
Further, the auxiliary material includes moisturizer, and the moisturizer is glycerol, the weight of the glycerol and the gelling agent Amount is than being 10:1~4:1.
The technical effects of the invention are that: Chinese medicine thinks that kidney mostly because liver feritin loses or anxiety and rage, is mutually burnt in fire, Liver Channel Blood is dry, and fire-evil pent-up forms, provided by the invention a kind of for treating the Chinese medicine composition of kidney, has kidney-nourishing qi-restoratives, promoting blood circulation Stagnation resolvation is removed obstruction in channels to relieve pain, blood-enrich and clearing heat and detoxicating effect, can effectively treat kidney, while outside the traditional chinese medicine composition of the invention With administration, application is convenient, and effective component can be absorbed rapidly by skin, position needed for targeting reaches, compared with radiation and chemotherapy to people Body Small side effects reduce patient's pain.
Specific embodiment
The present invention is further explained in the light of specific embodiments, so that those skilled in the art can be better Understand the present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
The present invention provides a kind of for treating the Chinese medicine composition of kidney, which is characterized in that the Chinese medicine composition is Exterior-applied formulation, the Chinese medicine composition include following traditional Chinese medicinal components: cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, river Rhizome of chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, evodia rutaecarpa, rhizoma zingiberis, wide perfume, cortex cinnamomi, Radix Astragali, monkshood, psoralea corylifolia, poria cocos, turmeric, party Ginseng, Herba Cistanches, Poria cocos, Radix Glycyrrhizae, monkshood, Rhizoma Atractylodis Macrocephalae, asarum, radix rehmanniae preparata, radix saposhnikoviae and rhizoma atractylodis.
Wherein, cimicifugae foetidae, which has, delivers promoting eruption, and clearing heat and detoxicating, the effect of lifting disease is analyzed through modern technologies, main containing liter Snippings stem is containing cimicifugine, salicylic acid, tannin, resin, caffeic acid, ferulic acid, isoferulic acid, cimicifugoside and cimigenol xyloside etc. Ingredient.
Rhizoma Et Radix Notopterygii is warm-natured, acrid flavour is bitter, enters bladder, kidney channel, has the function of scattered exterior cold, wind-damp dispelling, sharp joint, and main component is Volatile oil and cumarin.
Radix Angelicae Pubescentis has the function of wind-dispelling, wins wet, cold dispelling, analgesic, analyzes through modern technologies, mainly contains bitter scholar's Coumarins Compound, columbianetin and its caproate, osthole, different imperatorin, bergapten, xanthotoxin, dihydro mountain The ingredients such as celery alcohol angelate, columbianetin glycoside, Angelica pubescens alcohol, angelol, γ-aminobutyric acid and volatile oil.
The root of Dahurain angelica has wind-damp dispelling, apocenosis of invigorating blood circulation, and the effect of myogenic pain relieving is analyzed through modern technologies, mainly contains volatile oil, fragrant Legumin and its derivative, such as angelicin, Bai Danggui ether, Imperatoria ostruthium B prime, angelicotoxin, 3- methylene -6- cyclohexene, 11 charcoals The ingredients such as alkene -4, elemene, hexadecanoic acid, nonenol.
Ramulus cinnamomi has the function of sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, analyzes through modern technologies, mainly contains volatile oil, volatile oil Ingredient has cinnaldehydrum, Ergol, cinnamyl acetate, β-cadinene, Chang Pu's alkene, coumarin etc..
The effect of Chinese ephedra has inducing sweat and dispelling exogenous evils, freeings lung and relieving asthma, inducing diuresis for removing edema, through modern medical analysis, main component is more Kind alkaloid, such as ephedrine, d-pseudo-ephedrine, ephedine, separately containing volatile oil and flavone compound etc..
Radix Salviae Miltiorrhizae has the function of promoting blood circulation, calming heart and tranquilizing mind, apocenosis, analgesic, analyzes through modern technologies, mainly contains Radix Salviae Miltiorrhizae The ingredients such as ketone, isotanshinone, Cryptotanshinone, different Cryptotanshinone, methyltanshinone, hydroxyl tanshinone.
Rhizoma Chuanxiong has the function of that promote breath and open depression, method wind-dryness be wet, promoting blood circulation and stopping pain, analyzes through modern technologies, mainly contains Rhizoma Chuanxiong Piperazine, loline, Ligustilide, Rhizoma Chuanxiong naphthalene furan lactone, 3- butylidenephthalide, 3- butylidene -7- hydroxyl phthalide, butylphthalide, (3S) -3- normal-butyl -4- hydroxyl phthalide, 3- normal-butyl -3,6,7- trihydroxy -4,5,6,7- tetrahydro phthalides, new ligustilide, Senkyunolide, foreign Rhizoma Chuanxiong quinone, 2- methoxyl group -4- (3- methoxyl group -1- acrylic) phenol, 2- valeryl-benzene methyl, 4- hydroxyl Base -3- methoxybenzene alkene, 4-HBA, vanillic acid, caffeic acid, protocatechuic acid, ferulic acid, Chrysophanol, sedanonic acid, L- isoleucyl--Valine acid anhydride, L- valyl-Valine acid anhydride, loline, chuanxingol, urea pyrimidine, trimethylamine hydrochloride, Choline chloride, palmitinic acid, vanillic aldehyde, 1- acyl-B-carboline, spainulenol, cupreol, dilinoleic acid tripalmitin Equal ingredients.
Dried lacquer plays the role of broken silt, disperse accumulation, and through modern medical analysis, dried lacquer is effect of the laccol in raw lacquer in laccase Under, the black resin shape substance of generation is aoxidized in air.
Radix cyathulae has the function of diuresis of blood circulation promoting, through modern medical analysis, mainly look for the ketone that continues containing cup, 5- table cup look for stay ketone, Headdress flower cup look at stay ketone, dish of looking at stay beautiful, decortication that heir, beet is stayed the ingredients such as to cry out.
The root of Chinese clematis has the function of wind-damp dispelling, degrading the channel, dissolving phlegm saliva, dissipating the hypochondriac lump, analyzes through modern technologies, mainly contains original Anemonin often sees rattan sapogenin, table hederagenin, oleanolic acid, the root of Chinese clematis -23-O- arabinose saponin, Wheeling Celestial monosaccharide saponin, root of Chinese clematis disaccharides saponin, root of Chinese clematis trisaccharide saponin, three fine saponin of the root of Chinese clematis, root of Chinese clematis tetrose saponin, the root of Chinese clematis Pentasaccharides saponin, Cheng Lingxian -23-O- glucose saponin component.
Evodia rutaecarpa has warm in pain, the effect of supporing yang antidiarrheal, through modern medical analysis, main component containing evodene, Evodol, limonin, rutaecarpin, Rutaecarpine, evocarpine, hydroxyevodiamine, evodia rutaecarpa because Alkali, ocimenum, evodinone, evogin, evodine, 7- carboxyl rutaecarpin, dihydro Rutaecarpine, 14- first Sour Rutaecarpine, -4 (1H)-quinolone of 1- methyl -2- nonyl, primary colours amine, N- methyl anthranilic acid amine, synephrine, Dehydroevodiamine, evodiamide, demethyl evodiamide, 6a- acetic acid oxygroup -5- table limonin, 6 β-acetyl oxygen Base -5- table limonin, obakunone, Luo Danmei lactide, evodine acetic acid esters, 12a- hydroxyl evodol, Wu Zhu The ingredients such as cornel fruit amide I and evodia rutaecarpa fruit amide II.
Rhizoma zingiberis has effects that warming spleen and stomach for dispelling cold, recover Yang and smooth venation, and through modern medical analysis, main component includes α-zingiberene, β- Bisabolence, nerol, 1, 8-Cineole, alpha-terpineol, borneol, β-phellandrene, linalool, methyl nonyl ketone, lauro lene, lemon Alkene, sesquiphellandrene, α-curcumene and acetic acid Meng ester, the peppery alcohol of 6- ginger, 6- gingerone, the peppery ketenes of 8- ginger, the peppery glycol of 6-, 6- ginger Peppery glycol -5- acetic acid esters, the peppery glycol -3- acetic acid esters of 6- ginger, different ginger ketenes B, hexahydrocurcumin and ginger sugar rouge A, B, C.
Wide perfume has the effect of promoting qi circulation and relieving pain, reinforcing spleen to promote digestion, and through modern medical analysis, main component is containing in costen Ester, dehydro-α-curcumene, laurene, to P-cymene, linalool, beta-elemene, cloves alkene, cedrene, alpha, beta-lonone, cypress Another name for, α-costol, aplotaxene and constuslactone etc. also contain a variety of amino acid, betulin, stigmasterol and alkaloid Deng.
Cortex cinnamomi has effects that warming meridians and promoting circulation of qi, mends fire supporing yang, and through modern medical analysis, main component includes cinnaldehydrum, second Sour cassia bark ester, ethyl cinnamate, Ergol, benzaldehyde, coumarin, β-cadinene, calamus alkene and beta-elemene etc..
Radix Astragali has enhancing immune, liver protection diuresis, anti-aging resisting stress and widely antibacterial action, through modern medical analysis, Radix Astragali main component has formononetin, 3'- hydroxyl formononetin and its glycoside, 2', 3'- dihydroxy -7,4'- diformazan Oxygroup isoflavones, 7,2'- dihydroxy -3', 4'- dimethoxy isoflavan and its glycoside, 7,3'- dihydroxy -4', 5'- bis- Methoxyl group isoflavan, 3-hydroxy-9,10-dimethoxy pterocarpane and its glycoside etc..
Psoralea corylifolia has warming kidney and enhancing yang, warming spleen and stopping diarrha effect, and through modern medical analysis, psoralea corylifolia main component contains Psoralen Alicyclic lactone, isopsoralene, Coryfolin, Corylifolinin, bavachromene, Baku's chalcone and different new bus Method chalcone etc..
Poria cocos have effects that row water, dampness removing heat, through modern medical analysis, poria cocos main component include pachymic acid, Pachymic acid methyl esters, 16 Alpha-hydroxy eburicoic acid methyl esters, total triterpenes methyl esters, 3- hydrogenate loose Siberian cocklebur acid, eburicoic acid, dehydroeburicoic acid, Fu Siberian cocklebur eo-acid, pachyman, ergosterol, hendecanoic acid, lauric acid, lauric acid ester, palmitinic acid, dodecylene acid esters and octanoic acid Equal ingredients.
Turmeric has breaking blood and promoting the circulation of qi, inducing meastruation to relieve menalgia effect, and through modern medical analysis, turmeric main component includes turmeric Ketone, dehydroturmerone, also contain phellandrene, Cineole, borneol, curcumin, cupreol, cholesterine, stigmasterol, rape oil at zingiberene Sterol etc..
Radix Codonopsis has strengthening spleen and tonifying lung, the effect of nourishes blood and promotes the production of body fluid, through modern medical analysis, through modern medical analysis, mainly at Divide includes palmitinic acid, australene, borneol, syringin, TangshenosideⅠ, choline, loline etc., sterol and triterpenes components such as Pu Public English match alcohol and its acetic acid esters, freidelin, also containing syringaldehyde, vanillic acid, 5 hydroxymethyl furfural etc..
Herba Cistanches have effects that kidney-replenishing, benefiting essence-blood, and through modern medical analysis, Herba Cistanches main component includes D- sweet dew Alcohol, wheat-based diet, glycine betaine, Syring vulgaris phenolic glycoside, cupreol, boschnaloside, echinacosid and a variety of amino acid etc..
Poria cocos has effects that clearing damp and promoting diuresis, invigorating the spleen calming heart, and through modern medical analysis, Poria cocos main component includes that Poria cocos contains Pachymic acid, block acid, eburicoic acid, loose Siberian cocklebur acid, loose Siberian cocklebur eo-acid, Poria cocos is poly-, acetyl group pachymic acid dehydroeburicoic acid, β-Poria cocos are poly- Sugar, ergosterol, lecithin etc..
Radix Glycyrrhizae has effects that and middle removing toxic substances, coordinating the drug actions of a prescription, and through modern medical analysis, Radix Glycyrrhizae main component includes glycyrrhizin Element, the flavonoids such as triterpenes and glycyrrhizin, isoliquiritigenin, liquiritin, isoliquiritin, Neoliquiritin such as 24- hydroxyl enoxolone, And containing amaroid, resin etc..
Monkshood has the function of recuperating depleted yang, mends fire supporing yang, dispelling cold and removing dampness, analyzes through modern technologies, mainly contains the rhizome of Chinese monkshood Alkali, mesaconitine, Hypaconitine, talastisamine, black amine, coryneine chloride, different delphinine, benzoyl mesaconitine, The peaceful alkali of Xin Wuning alkali, monkshood, septentrionaline, karacoline, deoxyaconitine, Fuzitine alkali, songorine, urine are phonetic The ingredients such as pyridine, river oil aconitine, neojiangyouaconitine, Salsolinol.
There is Rhizoma Atractylodis Macrocephalae the effectiveness of strengthening the spleen and replenishing qi and eliminate dampness and have diuretic effect to have mainly contained α-and β-humulus grass through modern medical analysis Alkene, β-elemol, α curcumene, atractylone, 3 β-acetoxyl group atractylone, celery dienone, eucalyptol, palmitinic acid, hinesol, β-selinene and sesquiterpene lactone, including atractyloide-I ,-II ,-III and 8 β-ethyoxyl atractyloide-II, 14- The trans- Rhizoma Atractylodis Macrocephalae triol of each inner smooth acyl group -8- of the cis- reefing triol of acetyl group -12- climbing groundsel acyl group -8-, 14- acetyl group, 12- thousand In the cis- Rhizoma Atractylodis Macrocephalae triol of light light acyl group -8-, the trans- Rhizoma Atractylodis Macrocephalae triol of 12- climbing groundsel acyl group -8-, 12 Alpha-Methyl bytyry -14- acetyl The cis- Rhizoma Atractylodis Macrocephalae triol of base -8-, the trans- Rhizoma Atractylodis Macrocephalae triol of 12 Alpha-Methyl bytyry -14- acetyl group -8-, 14 Alpha-Methyl bytyry -8- are suitable Formula Rhizoma Atractylodis Macrocephalae triol, the trans- Rhizoma Atractylodis Macrocephalae triol of 14 Alpha-Methyl bytyry -8-, Scopoletin and the immunocompetent mannosan AM-3 of tool etc. Ingredient.
Asarum has effects that expelling wind and clearing away cold, analgesic warm lung, and through modern medical analysis, asarum main component includes that asarum contains Have asarone, methyl eugenol, methyleugenol, safrole, asarone, firpene, lauro lene, asarone, left-handed asarinin, Kakuol, asarum sieboldii volatile oil are containing ingredients such as α-thujene, laurene, α-terpinols.
Radix rehmanniae preparata has effects that nourishing yin and supplementing blood, through modern medical analysis, mainly contains iridoid and its glycoside, such as carpet bugle Alcohol, martynoside, Catalpol, carbohydrate, rehmanin, alkaloid and a variety of amino acid etc..
Radix saposhnikoviae has effects that expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, through modern medical analysis, the main alcohol of the chromone containing radix saposhnikoviae, cimicifugae foetidae Element, bergmot lactones, psoralen, volatile oil, mannitol, bitter taste glycosides etc..
The effect of rhizoma atractylodis are drying damp and strengthening spleen, expelling wind and clearing away cold, through modern medical analysis, main master containing rhizoma atractylodis contains volatile oil, wherein Main component is atractylol, atractylone, alditol and volatile oil, and principal component is hinesol, the ingredients such as β-eucalyptol in oil.
Above-mentioned Chinese medicine composition provided by the invention, through treated in vitro, according to theory of traditional Chinese medical science, each ingredient is made according to corresponding With that can be divided into four kinds of classification of drug of monarch, collaboration plays a role, and adjusts the pharmacological property of various Chinese medicines, have kidney-nourishing qi-restoratives, Activating microcirculation and removing stasis medicinal is removed obstruction in channels to relieve pain, blood-enrich and clearing heat and detoxicating effect, and kidney can be effectively treated.
Further, according to the present invention in Chinese medicine composition each traditional Chinese medicinal components monarch in the composition significance level And the severity for different disease sites, the embodiment of an above-mentioned Chinese medicine composition provided by the invention, the implementation The Chinese medicine composition of mode includes the traditional Chinese medicinal components of following parts by weight: 6~18 parts by weight of cimicifugae foetidae；8~15 parts by weight of Rhizoma Et Radix Notopterygii； 8~15 parts by weight of Radix Angelicae Pubescentis；3~9 parts by weight of the root of Dahurain angelica；3~9 parts by weight Chinese ephedra of ramulus cinnamomi, 8~15 parts by weight；12~28 weight of Radix Salviae Miltiorrhizae Part；6~18 parts by weight of Rhizoma Chuanxiong；10~20 parts by weight of radix cyathulae；10~25 parts by weight of dried lacquer；3~9 parts by weight of the root of Chinese clematis；Wu Zhu 10~25 parts by weight of cornel；6~18 parts by weight of rhizoma zingiberis；6~12 parts by weight of wide perfume；8~15 parts by weight of cortex cinnamomi；10~25 weight of Radix Astragali Measure part；3~9 parts by weight of monkshood；10~25 parts by weight of psoralea corylifolia；8~15 parts by weight of poria cocos；3~9 parts by weight of turmeric；Radix Codonopsis 10~25 parts by weight；10~25 parts by weight of Herba Cistanches；8~15 parts by weight of Poria cocos；8~15 parts by weight of Radix Glycyrrhizae；8~15 weight of monkshood Part；10~25 parts by weight of Rhizoma Atractylodis Macrocephalae；6~18 parts by weight of asarum；8~15 parts by weight of radix rehmanniae preparata；Windproof 8~15 parts by weight and rhizoma atractylodis 10 ~25 parts by weight.
Further, the Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight: 5~15 parts by weight of cimicifugae foetidae；It rises Numb 10~15 parts by weight；9~12 parts by weight of Rhizoma Et Radix Notopterygii；9~12 parts by weight of Radix Angelicae Pubescentis；3~9 parts by weight of the root of Dahurain angelica；3~9 parts by weight of ramulus cinnamomi 9~12 parts by weight of Chinese ephedra；15~25 parts by weight of Radix Salviae Miltiorrhizae；10~15 parts by weight of Rhizoma Chuanxiong；12~18 parts by weight of radix cyathulae；Dried lacquer 15~ 20 parts by weight；3~9 parts by weight of the root of Chinese clematis；15~20 parts by weight of evodia rutaecarpa；10~15 parts by weight of rhizoma zingiberis；6~12 weight of wide perfume Part；9~12 parts by weight of cortex cinnamomi；15~20 parts by weight of Radix Astragali；3~9 parts by weight of monkshood；15~20 parts by weight of psoralea corylifolia；Poria cocos 8~15 parts by weight；3~9 parts by weight of turmeric；15~20 parts by weight of Radix Codonopsis；15~20 parts by weight of Herba Cistanches；9~12 weight of Poria cocos Part；9~12 parts by weight of Radix Glycyrrhizae；9~12 parts by weight of monkshood；15~20 parts by weight of Rhizoma Atractylodis Macrocephalae；10~15 parts by weight of asarum；Radix rehmanniae preparata 9~ 12 parts by weight；Windproof 9~12 parts by weight and 15~20 parts by weight of rhizoma atractylodis.
Further, the Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight: 12 parts by weight of cimicifugae foetidae；Rhizoma Et Radix Notopterygii 10 Parts by weight；10 parts by weight of Radix Angelicae Pubescentis；5 parts by weight of the root of Dahurain angelica；5 parts by weight of ramulus cinnamomi；10 parts by weight of Chinese ephedra；20 parts by weight of Radix Salviae Miltiorrhizae；Rhizoma Chuanxiong 12 Parts by weight；15 parts by weight of radix cyathulae；18 parts by weight of dried lacquer；5 parts by weight of the root of Chinese clematis；18 parts by weight of evodia rutaecarpa；12 parts by weight of rhizoma zingiberis； 8 parts by weight of wide perfume；10 parts by weight of cortex cinnamomi；18 parts by weight of Radix Astragali；5 parts by weight of monkshood；18 parts by weight of psoralea corylifolia；10 weight of poria cocos Measure part；5 parts by weight of turmeric；18 parts by weight of Radix Codonopsis；18 parts by weight of Herba Cistanches；10 parts by weight of Poria cocos；10 parts by weight of Radix Glycyrrhizae；Monkshood 10 parts by weight；18 parts by weight of Rhizoma Atractylodis Macrocephalae；12 parts by weight of asarum；10 parts by weight of radix rehmanniae preparata；Windproof 10 parts by weight and 18 parts by weight of rhizoma atractylodis.
As an alternative embodiment, provided by the present invention for the exterior-applied formulation for the Chinese medicine composition for treating kidney Including by any one insecticide-applying way in immersion, attaching, spraying and sprinkling, the Chinese medicine composition is applied to patient Waist kidney area and renal cancer tumor metastasis site.The medicament of traditional treatment kidney mostly use it is oral, and in the present invention, without oral medicine Object directly grants affected area, does not take orally serious sense of discomfort, while quick, toxic side effect is small.
Further, the traditional Chinese medicinal components that the Chinese medicine composition includes are corresponding Chinese medicine raw medicine respectively through overcritical CO2Extract the Chinese medical extract obtained.Compared to traditionally, medicinal material is used as medicine by decocting for patch or decoction, of the invention The traditional Chinese medicinal components of Chinese medicine composition are that medicinal material passes through supercritical CO respectively2It extracts, active constituent content is high, and by overcritical CO2The traditional Chinese medicinal components of extraction are unfavorable for the material composition of drug absorption, substantially increase the Chinese medicine composition and percutaneously inhale Furthermore the efficiency of receipts also reduces the dosage that Chinese medicine composition is applied to affected part, it is excessive to patient to avoid topical agent dosage Bring sense of discomfort.
Further, the Chinese medicine composition for treating kidney of one embodiment of the invention further include medicinal material and pharmacy can The auxiliary material of receiving, the auxiliary material include gelling agent, moisturizer, preservative, antioxidant, emulsifier, thickener, Transdermal absorption promotion Any one or a few in agent.Chinese medicine composition for treating kidney of the invention, can by adding suitable auxiliary material Improve the formulation characteristic of the Chinese medicine composition.For example, gel preparations can be provided by adding gelling agent.For another example, pass through addition Moisturizer can be dry to avoid the Chinese medicine composition for being attached to skin, caused by avoiding pharmaceutical composition dry in skin surface not Suitable sense.For another example, the pot-life that the Chinese medicine composition can be appropriately extended by adding preservative.
Further, the exterior-applied formulation be patch, the Chinese medicine composition mixed with the auxiliary material be attached to papery or On cloth substrate.
Optionally, auxiliary material includes gelling agent, which includes xanthan gum and sodium carboxymethylcellulose, xanthan gum and carboxylic first The weight ratio of base sodium cellulosate is 10:1~1:1.In the present embodiment, Chinese medicine composition is mixed with the auxiliary material containing gelling agent It is attached on substrate, on the one hand gelling agent can be such that Chinese medicine composition is steadily uniformly adhered on substrate, on the other hand also It can enable in the Chinese medicine composition in use, sustained release extends in this in affected part under the action of Chinese medicine composition is in gelling agent The drug effect of drug composition reduces dressing change frequency, uses convenient for patient.Further, gelling agent include weight ratio be 10:1~ In sodium carboxymethylcellulose, the performances such as the gelling agent viscosity of formation, mobility are suitable for Chinese medicine composition and include the xanthan gum of 1:1 The auxiliary material mixing of the gelling agent is attached on substrate, and attachment thickness is uniform, not easily to fall off.
Still optionally further, moisturizer is glycerol, and the weight ratio of glycerol and gelling agent is 10:1~4:1.By making conduct The glycerol of moisturizer and the total amount ratio of gelling agent are 10:1~4:1, are formed after glycerol and gelling agent can be made to interact good The g., jelly-like form of sense of touch improves comfort level when patient uses.
The traditional Chinese medicinal components of the Chinese medicine composition for treating kidney of following embodiment of the present invention, select commercially available medicinal material liter Fiber crops, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, evodia rutaecarpa, rhizoma zingiberis, wide fragrant, meat Osmanthus, monkshood, psoralea corylifolia, poria cocos, turmeric, Radix Codonopsis, Herba Cistanches, Poria cocos, Radix Glycyrrhizae, monkshood, Rhizoma Atractylodis Macrocephalae, asarum, radix rehmanniae preparata, is prevented Radix Astragali Wind and rhizoma atractylodis are respectively through supercritical CO2It extracts and obtains.
The preparation method of the Chinese medicine composition for treating kidney of following embodiment of the present invention is as follows, weighs formula respectively The traditional Chinese medicinal components and auxiliary material of amount are prepared into the Chinese medicine group for being used to treat kidney of the dosage form according to the preparation method of corresponding dosage form Close object.It should be noted that in the examples below, mainly providing exterior-applied formulation is to attach the implementation used by patch Example, but this will not influence by any one insecticide-applying way in immersion, other attaching modes, spraying and sprinkling and be used to control The drug effect of the Chinese medicine composition of kidney is treated, what the only possible speed for influencing drug effect performance of the difference of insecticide-applying way and user used Degree of convenience and comfort level.
It please refers to shown in table 1, is the formula of the Chinese medicine composition of the embodiment of the present invention 1 to 6.
Clinic chooses 60 patients with renal cell carcinoma, and according to the weight of the kidney state of an illness, be divided into it is light, in, weigh three groups, every group is divided equally For two groups, mild group is administered with the Chinese medicine composition in embodiment 1 and embodiment 4, and middle disease group is with embodiment 2 and embodiment 5 In Chinese medicine composition application, severe group in embodiment 3 and embodiment 6 Chinese medicine composition be administered, application position be kidney Portion and metastases position, wherein patch is administered once daily, and spray is administered twice daily, continuous application one month.
Efficacy evaluation:
Significant in efficacy: patient mental is full, and blood urine, oedema are relieved, and CT shows that tumour knurl atrophy in kidney portion becomes smaller, He does not occur nascent tumor in position.
Effective: preferably, blood urine, oedema are alleviated, and kidney portion tumour has no growth, other portions for middle disease group and severe group spirit Position has no nascent tumor.
Invalid: illness is unchanged, and kidney portion tumour increases or nascent tumor occur in other positions.
Treatment results are shown: two kinds of dosage form therapeutic effect no significant differences, and the traditional Chinese medicine composition for treating kidney curative effect Significantly.Wherein, mild group 10 it is significant in efficacy, 8 effectively；Middle disease group 9 is significant in efficacy, and 10 effectively；Severe group 5 treatments Effect is significant, and 12 effectively, and 3 invalid.
Clinic, which is chosen, passes through kidney portion tumor resection and the similar patient of state of an illness weight 30, is divided into experimental group and control Group, control group are not processed, and experimental group imposes the Chinese medicine composition of the present embodiment 2, and continuous use 1 month, and track 3 months After observe, as a result, it has been found that: 15 patients of experimental group, physical recovery is good, weight gain, complication, while the state of an illness does not occur No relapse；In control group, 2 are restored preferably, and weight increased, 8 loss of appetite, and weight has no significant change, and 5 go out Existing complication.It can be seen that the Chinese medicine composition that the present invention is used to treat kidney shows stronger concertedness, there is nondominant hand The effectiveness of art treatment, it may also be used for firm curative effect prevents complication.
Embodiment described above is only to absolutely prove preferred embodiment that is of the invention and being lifted, protection model of the invention It encloses without being limited thereto.Those skilled in the art's made equivalent substitute or transformation on the basis of the present invention, in the present invention Protection scope within.Protection scope of the present invention is subject to claims.

Claims (10)

1. a kind of for treating the Chinese medicine composition of kidney, which is characterized in that the Chinese medicine composition includes following traditional Chinese medicinal components: Cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, evodia rutaecarpa, rhizoma zingiberis, it is wide fragrant, Cortex cinnamomi, Radix Astragali, monkshood, psoralea corylifolia, poria cocos, turmeric, Radix Codonopsis, Herba Cistanches, Poria cocos, Radix Glycyrrhizae, monkshood, Rhizoma Atractylodis Macrocephalae, asarum, radix rehmanniae preparata, Radix saposhnikoviae and rhizoma atractylodis.
2. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition includes following parts by weight Traditional Chinese medicinal components:
3. Chinese medicine composition according to claim 2, which is characterized in that the Chinese medicine composition includes following parts by weight Traditional Chinese medicinal components:
4. Chinese medicine composition according to claim 3, which is characterized in that the Chinese medicine composition includes following parts by weight Traditional Chinese medicinal components:
5. Chinese medicine composition according to any one of claims 1 to 4, which is characterized in that the Chinese medicine composition is outer With dosage form, the exterior-applied formulation include by any one insecticide-applying way in immersion, attaching, spraying and sprinkling will be described in Drug composition is applied to patient's waist kidney area and renal cancer tumor metastasis site.
6. Chinese medicine composition according to claim 5, which is characterized in that the Chinese medicine group that the Chinese medicine composition includes It is divided into corresponding Chinese medicine raw medicine respectively through supercritical CO2Extract the Chinese medical extract obtained.
7. Chinese medicine composition according to claim 6, which is characterized in that the Chinese medicine composition further includes medicinal material and medicine Acceptable auxiliary material is learned, the auxiliary material includes gelling agent, moisturizer, preservative, antioxidant, emulsifier, thickener, Transdermal absorption Any one or a few in promotor.
8. Chinese medicine composition according to claim 7, which is characterized in that the exterior-applied formulation is patch, the Chinese medicine group Conjunction object is mixed with the auxiliary material to be attached on papery or cloth substrate.
9. Chinese medicine composition according to claim 8, which is characterized in that the auxiliary material includes gelling agent, the gelling agent Including xanthan gum and sodium carboxymethylcellulose, the weight ratio of the xanthan gum and the sodium carboxymethylcellulose is 10:1~1:1.
10. Chinese medicine composition according to claim 8, which is characterized in that the auxiliary material includes moisturizer, the moisturizer For glycerol, the weight ratio of the glycerol and the gelling agent is 10:1~4:1.
CN201811203142.2A 2018-10-16 2018-10-16 It is a kind of for treating the Chinese medicine composition of kidney Pending CN109453347A (en)

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