CN109248297A - It is a kind of for treating the Chinese medicine composition of lung cancer - Google Patents

It is a kind of for treating the Chinese medicine composition of lung cancer Download PDF

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CN109248297A
CN109248297A CN201811141154.7A CN201811141154A CN109248297A CN 109248297 A CN109248297 A CN 109248297A CN 201811141154 A CN201811141154 A CN 201811141154A CN 109248297 A CN109248297 A CN 109248297A
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radix
medicine composition
chinese
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吴蓓莉
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Wu Beili
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a kind of for treating the Chinese medicine composition of lung cancer, the Chinese medicine composition is exterior-applied formulation, and Chinese medicine composition includes following traditional Chinese medicinal components: cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, the seed of cowherb, trigone, curcuma zedoary, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Angelicae Sinensis, the fleece-flower root, radices trichosanthis, monkshood, campanulaceae, the tuber of pinellia, smilax, glutinous rehmannia, Radix Notoginseng, rhizoma anemarrhenae and RADIX PAEONIAE RUBRA.The Chinese medicine composition has the function of kidney-nourishing promoting the dispersing function of the lung, activating microcirculation and removing stasis medicinal, promote breath and open depression, blood-enrich and clearing heat and detoxicating, can effectively treat lung cancer.

Description

It is a kind of for treating the Chinese medicine composition of lung cancer
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of for treating the Chinese medicine composition of lung cancer.
Background technique
Lung cancer betides tunica mucosa bronchiorum epithelium, and the disease incidence of lung cancer significantly increases in the past 50 years, and the disease incidence of lung cancer exists It has ranked first in male tumor, has accounted for the 2nd or the 3rd of women kinds of tumor in women disease incidence, meanwhile, lung cancer early stage is more Asymptomatic, most patients with lung cancer have been advanced stages when medical, and rehabilitation is difficult, have been that the one of threat human life and health is big Killer.
Scopes, the recipes for Saving Lives such as lung cancer category traditional Chinese medicine " lung product ", " breath is beautifully adorned ", " breathing with cough ", " lung cough ", " the lung-distension " are discussed: " breath Ben Zhizhuan, it is multiple as large as cup ... to wheeze to overflowing under right flank, it is for lung product." lung cancer generation, mostly because healthy energy is insufficient, gas Caused by accumulateing in yin deficiency void, phlegm and blood stasis, cancer are malicious.Lung covering other viscera it is dirty, occupy the part of the body cavity above the diaphragm housing the heart and lungs, be easily dry wound intolerant to fever and chills, interior master one The gas of body.Exopathogen invading the interior, resistance is in the heart, and impairment of dispersing and descending function of the lung, functional activity of QI being not smooth blocks train of thought, stops up and be phlegm, phlegm and blood stasis, in cancer poison Accumulate, to form lump.This causes reality because of void to fall ill because of void." difficult through 56 hardly possible ": " product of lung, it is beautifully adorned that name says breath, It under right flank, covers as large as cup, long endlessly, makes us spilling wash rice fever and chills, breath with cough, send out pulmonary abscess ".Song's recipes for Saving Lives is said: " breath Ben Zhizhuan, It under right flank, covers as large as cup, wheezes and run quickly that overflow be to examine its floating pulse and hair, color are white, pathogenic QI in the body is inverse, and gas lack in backache, likes for lung product Forget mesh to close the eyes, skin is cold, pain when in skin, or as lice pecks, or as needle pierces." " product person, be born in the five internal organs yin gas ... ... this by yin-yang Discord, internal organs are weak, and ailment said due to cold or exposure fights it, so be product being to gather." " institute of the gas of sorrow happiness anger, people cannot cross and then hurt without person The five internal organs.Inverse biography gram is not all right when four, is staying knot and being five products.
Lung cancer western medical treatment has surgical intervention, radiotherapy, chemotherapy and immunotherapy, and radiotherapy and chemistry are treated Method is method more universal at present, but patient will be by great pain, while cure rate is low.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of for treating the Chinese medicine composition of lung cancer, can be enhanced and exempts from Epidemic disease, right supporting anticancer improve conditions of patients and reduce patient suffering.
In order to solve the above-mentioned technical problems, the present invention provides a kind of for treating the Chinese medicine composition of lung cancer, feature Be, the Chinese medicine composition includes following traditional Chinese medicinal components: cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, It is radix cyathulae, dried lacquer, the root of Chinese clematis, the seed of cowherb, trigone, curcuma zedoary, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Angelicae Sinensis, the fleece-flower root, radices trichosanthis, attached Son, campanulaceae, the tuber of pinellia, smilax, glutinous rehmannia, Radix Notoginseng, rhizoma anemarrhenae and RADIX PAEONIAE RUBRA.
The Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight in one of the embodiments:
The Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight in one of the embodiments:
The Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight in one of the embodiments:
The Chinese medicine composition is exterior-applied formulation in one of the embodiments, and the exterior-applied formulation includes passing through leaching It steeps, attach, the Chinese medicine composition is applied to patient chest and back by any one insecticide-applying way in spraying and sprinkling Portion.
The traditional Chinese medicinal components that the Chinese medicine composition includes in one of the embodiments, are corresponding Chinese medicine raw medicine Respectively through supercritical CO2Extract the Chinese medical extract obtained.
The Chinese medicine composition further includes medicinal material and pharmaceutically acceptable auxiliary material in one of the embodiments, described Auxiliary material includes gelling agent, moisturizer, preservative, antioxidant, emulsifier, thickener, any one in skin penetration enhancer Or it is several.
The exterior-applied formulation is patch in one of the embodiments, and the Chinese medicine composition mixes attached with the auxiliary material In papery or cloth substrate.
The auxiliary material includes gelling agent in one of the embodiments, and the gelling agent includes that xanthan gum and carboxymethyl are fine The weight ratio of the plain sodium of dimension, the xanthan gum and the sodium carboxymethylcellulose is 10:1~1:1.
The auxiliary material includes moisturizer in one of the embodiments, and the moisturizer is glycerol, the glycerol and institute The weight ratio for stating gelling agent is 10:1~4:1.
The technical effects of the invention are that: it is provided by the invention a kind of for treating the Chinese medicine composition of lung cancer, there is benefit Kidney promoting the dispersing function of the lung, activating microcirculation and removing stasis medicinal, promote breath and open depression, blood-enrich and clearing heat and detoxicating effect, the effect of to reach right supporting anticancer, simultaneously The traditional chinese medicine composition of the invention topical administration, effective component can be absorbed rapidly by skin, position needed for targeting reaches, to human body Small side effects effectively mitigate patient's pain, improve patient's state of an illness.
Specific embodiment
The present invention is further explained in the light of specific embodiments, so that those skilled in the art can be more preferable The understanding present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
The present invention provides a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the Chinese medicine composition is Exterior-applied formulation, the Chinese medicine composition include following traditional Chinese medicinal components: cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, the seed of cowherb, trigone, curcuma zedoary, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Angelicae Sinensis, the fleece-flower root, smallpox Powder, monkshood, campanulaceae, the tuber of pinellia, smilax, glutinous rehmannia, Radix Notoginseng, rhizoma anemarrhenae and RADIX PAEONIAE RUBRA.
Wherein, cimicifugae foetidae, which has, delivers promoting eruption, and clearing heat and detoxicating, the effect of lifting disease is analyzed through modern technologies, mainly contained Cimicifugae foetidae rhizome contains cimicifugine, salicylic acid, tannin, resin, caffeic acid, ferulic acid, isoferulic acid, cimicifugoside, cimigenol xyloside Equal ingredients.
Rhizoma Et Radix Notopterygii is warm-natured, acrid flavour is bitter, enters bladder, kidney channel, has the function of scattered exterior cold, wind-damp dispelling, sharp joint it is necessary to ingredient For volatile oil and cumarin.
Radix Angelicae Pubescentis has the function of wind-dispelling, wins wet, cold dispelling, analgesic, analyzes through modern technologies, mainly contains bitter scholar's coumarin Class compound, columbianetin and its caproate, osthole, different imperatorin, bergapten, xanthotoxin, dihydro The ingredients such as oroselol angelate, columbianetin glycoside, Angelica pubescens alcohol, angelol, γ-aminobutyric acid and volatile oil.
The root of Dahurain angelica has wind-damp dispelling, apocenosis of invigorating blood circulation, and the effect of myogenic pain relieving is analyzed through modern technologies, mainly contains volatile oil, Cumarin and its derivative, such as angelicin, white Radix Angelicae Sinensis ether, Imperatoria ostruthium B prime, angelicotoxin.Also contain volatile oil, volatile oil In the ingredients such as -6- of methylene containing 3- cyclohexene, 11 charcoal alkene -4, elemene, hexadecanoic acid, nonenol.
Ramulus cinnamomi has the function of sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, analyzes through modern technologies, mainly contains volatile oil, volatile oil Ingredient has cinnaldehydrum, Ergol, cinnamyl acetate, β-cadinene, Chang Pu's alkene, coumarin etc..
Chinese ephedra has inducing sweat and dispelling exogenous evils, freeings lung and relieving asthma, inducing diuresis for removing edema, through modern medical analysis, main component is a variety of lifes Alkaloids, such as ephedrine, d-pseudo-ephedrine, ephedine, separately containing volatile oil and flavone compound etc..
Radix Salviae Miltiorrhizae has the function of promoting blood circulation, calming heart and tranquilizing mind, apocenosis, analgesic, analyzes through modern technologies, mainly contains pellet Join the ingredients such as ketone, isotanshinone, Cryptotanshinone, different Cryptotanshinone, methyltanshinone, hydroxyl tanshinone.
Rhizoma Chuanxiong has the function of that promote breath and open depression, method wind-dryness be wet, promoting blood circulation and stopping pain, analyzes through modern technologies, mainly contains Rhizoma Chuanxiong Piperazine, loline, Ligustilide, Rhizoma Chuanxiong naphthalene furan lactone, 3- butylidenephthalide, 3- butylidene -7- hydroxyl phthalide, butylphthalide, (3S) -3- normal-butyl -4- hydroxyl phthalide, 3- normal-butyl -3,6,7- trihydroxy -4,5,6,7- tetrahydro phthalides, new ligustilide, Senkyunolide, foreign Rhizoma Chuanxiong quinone, 2- methoxyl group -4- (3- methoxyl group -1- acrylic) phenol, 2- valeryl-benzene methyl, 4- hydroxyl Base -3- methoxybenzene alkene, 4-HBA, vanillic acid, caffeic acid, protocatechuic acid, ferulic acid, Chrysophanol, plucked instrument pellet ketone Acid, L- isoleucyl--Valine acid anhydride, L- valyl-Valine acid anhydride, loline, chuanxingol, urea pyrimidine, hydrochloric acid front three Amine, choline chloride, palmitinic acid, vanillic aldehyde, 1- acyl-B-carboline, spainulenol, cupreol, dilinoleic acid palmitinic acid The ingredients such as glyceride.
Dried lacquer plays the role of broken silt, disperse accumulation, and through modern medical analysis, dried lacquer is work of the laccol in raw lacquer in laccase Under, the black resin shape substance of generation is aoxidized in air.
Radix cyathulae has the function of diuresis of blood circulation promoting, through modern medical analysis, mainly look for the ketone that continues containing cup, 5- table cup look for stay ketone, Headdress flower cup, which is look at, stays ketone, dish of looking to stay beautiful, decortication that heir, beet is stayed to cry out.
The root of Chinese clematis has the function of wind-damp dispelling, degrading the channel, dissolving phlegm saliva, dissipating the hypochondriac lump, analyzes, mainly contains through modern technologies Protoanemonin often sees rattan sapogenin, table hederagenin, oleanolic acid, the root of Chinese clematis -23-O- arabinose saponin, prestige Medicine xiaolingxian monosaccharide saponin, root of Chinese clematis disaccharides saponin, root of Chinese clematis trisaccharide saponin, three fine saponin of the root of Chinese clematis, root of Chinese clematis tetrose saponin, prestige Medicine xiaolingxian pentasaccharides saponin, at ingredients such as medicine xiaolingxian -23-O- glucose saponin, root of Chinese clematis table disaccharides saponins.
The seed of cowherb has the function of promoting blood circulation and removing obstruction in channels, swelling and pain relieving.Through modern medical analysis, main soap containing the seed of cowherb Glucoside, isosaponaretin, also contains the ingredients such as phytin, phosphatide, stigmasterol at seed of cowherb glycosides displayed.
Trigone has effects that breaking blood and promoting the circulation of qi, clearing stagnation and killing pain, through modern medical analysis, mainly containing benzyl carbinol, to benzene two Phenol, hexadecylic acid, dehydro-α-curcumene, 3,4- dihydro -8- hydroxy-3-methyl -1H2- chromene -4- ketone, 1- hydroxyl -2- second The ingredients such as acyl group -4- methylbenzene, β elemene, 2- furan alcohol, 2- acetyl pyrrole.Contain a variety of organic acids: succinic acid, trigone again Acid, 9-11- octadecadienoic acid, 9-12- octadecadienoic acid, 10- nonadecenoic acid, 11- eicosenoic acid, benzoic acid, 3- benzene- 2- acrylic acid, azelaic acid, decanedioic acid and C8-C10, C12, C14-C20 fatty acid.Also containing formoononetin, stigmasterol, The ingredients such as cupreol, Daucosterol.
The effect of curcuma zedoary promoting the circulation of qi blood-breaking and clearing stagnation and killing pain, through modern medical analysis, the main ketenes of furans containing curcuma zedoary, borneol, Germacrone, nopinene, lauro lene, limonene, terpinene, isoborneol, cloves alkene, curcumene, cloves alkene epoxides, ginger The ingredients such as flavones, ar-turmerone, curdione and Curcumenol, isocurcumenol.
Radix Astragali has enhancing immune function, liver protection diuresis, anti-aging resisting stress and widely antibacterial action, through modern medicine Analysis, Radix Astragali contain flavones, saponin constituents；Wherein flavones ingredient such as formononetin, 3'- hydroxyl formononetin (hair stamen Isoflavones) and its glycoside, 2', 3'- dihydroxy -7,4'- dimethoxy isoflavones, 7,2'- dihydroxy -3', 4'- diformazan Oxygroup isoflavan and its glycoside, 7,3'- dihydroxy -4', 5'- dimethoxy isoflavan, 3- hydroxyl -9,10- dimethoxy The some of them ingredient such as red sandalwood alkane and its glycoside has stronger antioxidant activity.Saponin constituents have astragalus saponin I~ VIII and soyasaponins I；Astragaloside IV (i.e. astragaloside Ⅳ) and Radix Astragali second glucoside.
There is Rhizoma Atractylodis Macrocephalae the effectiveness of strengthening the spleen and replenishing qi and eliminate dampness and have diuretic effect to have mainly contained α-and β-humulus grass through modern medical analysis Alkene, β-elemol, α curcumene, atractylone, 3 β-acetoxyl group atractylone, celery dienone, eucalyptol, palmitinic acid, Mao Shu Alcohol, β-selinene and sesquiterpene lactone, including atractyloide-I ,-II ,-III and 8 β-ethyoxyl atractyloide- II, each inner smooth trans- Rhizoma Atractylodis Macrocephalae three of acyl group -8- of the cis- reefing triol of 14- acetyl group -12- climbing groundsel acyl group -8-, 14- acetyl group Alcohol, the cis- Rhizoma Atractylodis Macrocephalae triol of 12- climbing groundsel light acyl group -8-, the trans- Rhizoma Atractylodis Macrocephalae triol of 12- climbing groundsel acyl group -8-, 12 Alpha-Methyl butyryl The cis- Rhizoma Atractylodis Macrocephalae triol of base -14- acetyl group -8-, the trans- Rhizoma Atractylodis Macrocephalae triol of 12 Alpha-Methyl bytyry -14- acetyl group -8-, 14 Alpha-Methyls The cis- Rhizoma Atractylodis Macrocephalae triol of bytyry -8-, the trans- Rhizoma Atractylodis Macrocephalae triol of 14 Alpha-Methyl bytyry -8-, Scopoletin and tool are immunocompetent sweet Reveal the ingredients such as glycan.
Poria cocos has the effectiveness of invigorating spleen for diuresis and warm kidney calming heart, through modern medical analysis, mainly contains pachymic acid, 16 α-hydroxyl Base eburicoic acid, 3 beta-hydroxies -7.9 (11), 24- wool steroid triolefin -21- acid, pachymic acid methyl esters, 16 Alpha-hydroxy eburicoic acid methyl esters, Total triterpenes methyl esters, 3- hydrogenate loose Siberian cocklebur acid, eburicoic acid, dehydroeburicoic acid, Poria cocos eo-acid, pachyman, the secondary poly-, branch of Poria cocos Callose H11, ergosterol, hendecanoic acid, lauric acid, lauric acid ester, palmitinic acid, dodecylene acid esters and pungent The ingredients such as acid.
Radix Angelicae Sinensis has the function of inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, moisturizing dryness and lubricating intestine, analyzes through modern technologies, mainly contains Aden Base phthalide, the positive the eleventh of the twelve Earthly Branches ketone of adjacent carboxyl benzene, Δ 2, the ingredients such as 4- dihydro acid phthalic anhydride.
The fleece-flower root has the function of active blood-nourishing, strengthening the bones and muscles, nourishing liver and kidney, through modern medical analysis, mainly contains containing anthraquinone Class compound, including rheum emodin, Chrysophanol and Physcion, Rhein, chrysophanic acid anthrone etc.；The chemical combination of class containing stilbene again Object, including resveratrol, piceid, 2,3,5,4 '-tetrahydroxy Stilbene -2-O-D- glycosides, 2,3,5,4'- tetrahydroxys two Styrene -2-O- β-D-Glucose glycosides -2 "-O- gallate, 2,3,5,4 '-tetrahydroxystilbene -2-O- glycosides -3 "-O- Gallate, gallic acid, dextrorotation cachou extract, 3-O- nutgall acyl-cachou extract, 3-O- nutgall acyl-epicatechin, 3- O- nutgall acyl original Cyanidin B-2,3,3 '-two-O- nutgall acyl original Cyanidins and cupreol etc..
Radices trichosanthis have the function of clearing heat-fire, apocenosis detumescence, through modern medical analysis, mainly contain trichosanthin, A variety of amino acid including α hydroxymethylserine, aspartic acid, citrulling, serine, glutamic acid, threonine, glycine, figured silk fabrics Propylhomoserin, tyrosine, phenylalanine, histidine, lysine, arginine, ornithine and peptides, ribose, xylose, arabinose, Glucose etc..
Monkshood has the function of recuperating depleted yang, mends fire supporing yang, dispelling cold and removing dampness, analyzes through modern technologies, mainly contains the rhizome of Chinese monkshood Alkali, mesaconitine, Hypaconitine, talastisamine, black amine, coryneine chloride, different delphinine, benzoyl mesaconitine, The peaceful alkali of Xin Wuning alkali, monkshood, septentrionaline, karacoline, deoxyaconitine, Fuzitine alkali, songorine, urine are phonetic Pyridine, river oil aconitine, neojiangyouaconitine, Salsolinol etc..
Campanulaceae has promoting the dispersing function of the lung, and relieving sore-throat, eliminating the phlegm, the effect of apocenosis, Platycodin A C D, C, D, D2, D3 remove celery glycosyl campanulaceae Raddeanin A, D3,2-O-=acetyl group platycodin D 2,3-O- acetyl group platycodin D 2, senega-saponin D, D2,2-O- acetyl group Senega-saponin D, D2,3-O- acetyl group senega-saponin D, D2, campanulaceae glucoside acid-A methyl esters, 2-O- methyl campanulaceae glucoside acid-A methyl esters, tangerine Obstruct the ingredients such as glucoside acid-A lactone.
The tuber of pinellia has effects that eliminating dampness and eliminating phlegm, dissolving lump and resolving mass and stopping nausea and vomiting by lowering the adverse flow of QI, through modern medical analysis, the tuber of pinellia mainly at Divide includes 3- acetylaminohydroxyphenylarsonic acid 5- methyl isoxazole, butyl vinyl ether, 3- methyl eicosane, hexadeeene diacid(hexadecendioic acid), 2- chloropropene Sour methyl esters, anethole, benzaldehyde, 1,5-PD, 2- methylpyrazine, citral, 1- octene, β elemene, methyln nonyl ketone, 9- heptadecanol, ethyl palmitate, valeraldehyde oxime, sanedrine, choline, cupreol, Daucosterol, alcapton, former catechu The peppery ketenes of aldehyde, ginger, baicalin, baicalein, the peppery alcohol of ginger etc..
Smilax has effects that removing toxic substances dehumidifying, and through modern medical analysis, main component includes astilbin, different Huang The ingredients such as Qi glycosides, daucosterol, succinic acid, matter of mixing, flavones, cupreol.
Glutinous rehmannia has the function of clearing heat and cooling blood and nourishing Yin and clearing heat, and through modern medical analysis, main component is with glucoside, carbohydrate Based on, wherein glucoside is again based on iridoid glycosides, including motherwort glucoside, Aucubin, Catalpol, appropriate double glucosides of U.S. benefit, all Square rafter glucoside, all square rafter glucoside, 8- table vomiting nut glucoside acid, boat bone oxalic acid, 6-O-E- asafoetide acyl group ajugol, 6-O-Z- asafoetide acyl Base ajugol etc.；Carbohydrate include D-Glucose, D- galactolipin, D-Fructose, sucrose, gossypose, stachyose, manninotriose and The ingredients such as verbascose.
Radix Notoginseng has the effect of enriching blood the scattered stasis of blood, and through modern medical analysis, main component includes notoginsenoside, dencichine, three The ingredients such as seven flavones, notoginseng polysaccharide, notoginseng haulm polysaccharide and beta-elemene.
Rhizoma anemarrhenae has effects that nourishing yin and lessening fire, moisturizing dryness and lubricating intestine, and through modern medical analysis, rhizoma anemarrhenae mainly contains smilax saponin The ingredients such as member, markogenin, new branch root of Dahurian angelica sapogenin, choline, niacin, pantothenic acid, mangiferin.
Radix paeoniae rubra has stasis eliminatings, analgesic, cool blood, detumescence.Through modern medical analysis, radix paeoniae rubra main component is Paeoniflorin, oxidation Paeoniflorin, benzoylpaeoniflorin, albiflorin, Paeoniflorin without ketone, nutgall acyl Paeoniflorin, β-pinane -10- alkenyl-β-vicianin, Lactiflorin, paeonilactone A, B, C, cupreol, Daucosterol, benzoic acid and paeonol.
Above-mentioned Chinese medicine composition provided by the invention, through treated in vitro, according to theory of traditional Chinese medical science, each ingredient is according to corresponding Effect can be divided into four kinds of classification of drug of monarch, and collaboration plays a role, and adjusts the pharmacological property of various Chinese medicines, can pass through back Portion and the through lesion of chest strong osmotic, with kidney-nourishing promoting the dispersing function of the lung, activating microcirculation and removing stasis medicinal, promote breath and open depression, blood-enrich and heat-clearing solution The effect of poison, can effectively treat lung cancer.
Further, according to the present invention in Chinese medicine composition each traditional Chinese medicinal components monarch in the composition important journey Degree and for different disease sites severity, the embodiment of an above-mentioned Chinese medicine composition provided by the invention, the reality The Chinese medicine composition for applying mode includes the traditional Chinese medicinal components of following parts by weight: 3~12 parts by weight of cimicifugae foetidae；10~40 weight of Rhizoma Et Radix Notopterygii Part；3~12 parts by weight of Radix Angelicae Pubescentis；5~25 parts by weight of the root of Dahurain angelica；3~12 parts by weight of ramulus cinnamomi；10~40 parts by weight of Chinese ephedra；Radix Salviae Miltiorrhizae 5~ 25 parts by weight；5~30 parts by weight of Rhizoma Chuanxiong；10~40 parts by weight of radix cyathulae；5~25 parts by weight of dried lacquer；5~30 weight of the root of Chinese clematis Part；3~18 parts by weight of the seed of cowherb；5~30 parts by weight of trigone；5~20 parts by weight of curcuma zedoary；10~40 parts by weight of Radix Astragali；Rhizoma Atractylodis Macrocephalae 5~30 parts by weight；5~30 parts by weight of Poria cocos；10~40 parts by weight of Radix Angelicae Sinensis；5~25 parts by weight of the fleece-flower root；Radices trichosanthis 5~30 Parts by weight；5~25 parts by weight of monkshood；10~40 parts by weight of campanulaceae；5~30 parts by weight of the tuber of pinellia；3~18 parts by weight of smilax；Ground Yellow 5~30 parts by weight；3~18 parts by weight of Radix Notoginseng；3~18 parts by weight of 5~30 parts by weight of rhizoma anemarrhenae and RADIX PAEONIAE RUBRA.
Further, the Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight: 5~15 parts by weight of cimicifugae foetidae；It rises Numb 3~9 parts by weight；15~30 parts by weight of Rhizoma Et Radix Notopterygii；3~9 parts by weight of Radix Angelicae Pubescentis；6~18 parts by weight of the root of Dahurain angelica；3~9 parts by weight of ramulus cinnamomi； 15~30 parts by weight of Chinese ephedra；6~18 parts by weight of Radix Salviae Miltiorrhizae；10~20 parts by weight of Rhizoma Chuanxiong；15~30 parts by weight of radix cyathulae；Dried lacquer 6~ 18 parts by weight；3~20 parts by weight of the root of Chinese clematis；5~15 parts by weight of the seed of cowherb；10~20 parts by weight of trigone；10~20 weight of curcuma zedoary Measure part；15~30 parts by weight of Radix Astragali；10~20 parts by weight of Rhizoma Atractylodis Macrocephalae；10~20 parts by weight of Poria cocos；10~30 parts by weight of Radix Angelicae Sinensis；What 6~18 parts by weight of the tuber of multiflower knotweed；10~20 parts by weight of radices trichosanthis；6~18 parts by weight of monkshood；5~25 parts by weight of campanulaceae；The tuber of pinellia 10~ 20 parts by weight；5~15 parts by weight of smilax；10~20 parts by weight of glutinous rehmannia；5~15 parts by weight of Radix Notoginseng；10~20 weight of rhizoma anemarrhenae Part and 5~15 parts by weight of RADIX PAEONIAE RUBRA.
Further, the Chinese medicine composition includes the traditional Chinese medicinal components of following parts by weight: 5 parts by weight of cimicifugae foetidae；Rhizoma Et Radix Notopterygii 20 Parts by weight；5 parts by weight of Radix Angelicae Pubescentis；12 parts by weight of the root of Dahurain angelica；5 parts by weight of ramulus cinnamomi；20 parts by weight of Chinese ephedra；12 parts by weight of Radix Salviae Miltiorrhizae；Rhizoma Chuanxiong 15 Parts by weight；20 parts by weight dried lacquer of radix cyathulae, 12 parts by weight；15 parts by weight of the root of Chinese clematis；10 parts by weight of the seed of cowherb；15 weight of trigone Part；10 parts by weight of curcuma zedoary；20 parts by weight of Radix Astragali；15 parts by weight of Rhizoma Atractylodis Macrocephalae；15 parts by weight of Poria cocos；20 parts by weight of Radix Angelicae Sinensis；The fleece-flower root 12 parts by weight；15 parts by weight of radices trichosanthis；12 parts by weight of monkshood；25 parts by weight of campanulaceae；15 parts by weight of the tuber of pinellia；10 weight of smilax Part；15 parts by weight of glutinous rehmannia；10 parts by weight of Radix Notoginseng；10 parts by weight of 15 parts by weight of rhizoma anemarrhenae and RADIX PAEONIAE RUBRA.
As an alternative embodiment, provided by the present invention for the external preparation for the Chinese medicine composition for treating lung cancer Type includes being applied to the Chinese medicine composition by any one insecticide-applying way in immersion, attaching, spraying and sprinkling Patient chest and back, can be gone directly lesion with strong osmotic.The medicament of traditional treatment lung cancer mostly use it is oral, and in the present invention, Affected area is directly granted without oral drugs, does not take orally important sense of discomfort, while quick, toxic side effect is small.
Further, the traditional Chinese medicinal components that the Chinese medicine composition includes are that corresponding Chinese medicine raw medicine is faced through super respectively Boundary CO2Extract the Chinese medical extract obtained.Compared to traditionally, medicinal material is used as medicine by decocting for patch or decoction, the present invention Chinese medicine composition traditional Chinese medicinal components be medicinal material pass through supercritical CO respectively2It extracts, active constituent content is high, and by super Critical CO2The traditional Chinese medicinal components of extraction are unfavorable for the material composition of drug absorption, substantially increase Chinese medicine composition warp Skin absorb efficiency, furthermore also reduce the dosage that Chinese medicine composition is applied to affected part, avoid topical agent dosage it is excessive to Patient's bring sense of discomfort.
Further, one embodiment of the invention further includes medicinal material and pharmacy for treating the Chinese medicine composition of lung cancer Acceptable auxiliary material, the auxiliary material include gelling agent, moisturizer, preservative, antioxidant, emulsifier, thickener, Transdermal absorption Any one or a few in promotor.Chinese medicine composition for treating lung cancer of the invention, which passes through, adds suitable auxiliary material, The formulation characteristic of the Chinese medicine composition can be improved.For example, gel preparations can be provided by adding gelling agent.For another example, pass through Addition moisturizer can be dry to avoid the Chinese medicine composition for being attached to skin, and pharmaceutical composition is avoided to draw in skin surface drying The sense of discomfort risen.For another example, the pot-life that the Chinese medicine composition can be appropriately extended by adding preservative.
Further, the exterior-applied formulation be patch, the Chinese medicine composition mixed with the auxiliary material be attached to papery or On cloth substrate.
Optionally, auxiliary material includes gelling agent, which includes xanthan gum and sodium carboxymethylcellulose, xanthan gum and carboxylic The weight ratio of sodium carboxymethylcellulose pyce is 10:1~1:1.In the present embodiment, Chinese medicine composition and the auxiliary material containing gelling agent Mixing is attached on substrate, and on the one hand gelling agent can be such that Chinese medicine composition is steadily uniformly adhered on substrate, another party Face can also enable in the Chinese medicine composition in use, sustained release extends in affected part under the action of Chinese medicine composition is in gelling agent The drug effect of the Chinese medicine composition reduces dressing change frequency, uses convenient for patient.Further, gelling agent includes that weight ratio is For the xanthan gum of 10:1~1:1 in sodium carboxymethylcellulose, the performances such as the gelling agent viscosity of formation, mobility are suitable for Chinese traditional medicine composition Object is mixed with the auxiliary material for including the gelling agent and is attached on substrate, and attachment thickness is uniform, not easily to fall off.
Still optionally further, moisturizer is glycerol, and the weight ratio of glycerol and gelling agent is 10:1~4:1.By making conduct The glycerol of moisturizer and the total amount ratio of gelling agent are 10:1~4:1, are formed after glycerol and gelling agent can be made to interact good The g., jelly-like form of sense of touch improves comfort level when patient uses.
The traditional Chinese medicinal components of the Chinese medicine composition for treating lung cancer of following embodiment of the present invention, select commercially available medicinal material: rising Fiber crops, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, the seed of cowherb, trigone, curcuma zedoary, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Angelicae Sinensis, the fleece-flower root, radices trichosanthis, monkshood, campanulaceae, the tuber of pinellia, smilax, glutinous rehmannia, Radix Notoginseng, rhizoma anemarrhenae and radix paeoniae rubra Medicine is respectively through supercritical CO2It extracts and obtains.
The preparation method of the Chinese medicine composition for treating lung cancer of following embodiment of the present invention is as follows, weighs match respectively The traditional Chinese medicinal components and auxiliary material just measured, according to the preparation method of corresponding dosage form be prepared into the dosage form for treating in lung cancer Drug composition.It should be noted that in the examples below, mainly providing exterior-applied formulation and being used by patch attaching Embodiment, but this will not influence by any one insecticide-applying way in immersion, other attaching modes, spraying and sprinkling For treating the drug effect of the Chinese medicine composition of lung cancer, the difference of insecticide-applying way is only possible to influence the speed and use that drug effect plays The degree of convenience and comfort level that family uses.
It please refers to shown in table 1, is the formula of the Chinese medicine composition of the embodiment of the present invention 1 to 6.
Clinic chooses 180 patients with lung cancer, and according to the weight of the lung cancer state of an illness, be divided into it is light, in, severe group, every group 60 Example, every group is divided into 6 groups again, implements the Chinese medicine composition of embodiment 1 to 6 respectively once a day according to patient body situation The chest and back that are applied to patients with lung cancer carry out treatment in one month by a definite date.Treatment results show, either mild group, in The state of an illness of disease group or severe group, patients with lung cancer is alleviated, with the extension for the treatment of time, cough, pectoralgia and hemoptysis Symptom is substantially reduced, and lung function, blood gas analysis index have clear improvement, and tumor portion area is reduced.
Clinic chooses the similar and lung cancer phase patient by operation excision of 120 light and heavy degrees and is divided into 3 groups, suffers between group The physical condition of person is similar, and first group carries out bimestrial treatment by a definite date with patch prepared by embodiment 1, and application is primary daily； Second group carries out bimestrial treatment by a definite date with spray prepared by embodiment 5, and application is primary daily；Third group is without application. Treatment results are shown: first group and second group does not recur, only first group of appearance, 1 complication, and 12 appearance occurs in third group Recurrence, 9 there is complication.It can be seen that the Chinese medicine composition that the present invention is used to treat lung cancer can assist operative treatment, have There is firm curative effect, prevents the effect of complication.
Embodiment described above is only to absolutely prove preferred embodiment that is of the invention and being lifted, protection of the invention Range is without being limited thereto.Those skilled in the art's made equivalent substitute or transformation on the basis of the present invention, in this hair Within bright protection scope.Protection scope of the present invention is subject to claims.

Claims (10)

1. a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the Chinese medicine composition includes following traditional Chinese medicinal components: Cimicifugae foetidae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the root of Dahurain angelica, ramulus cinnamomi, Chinese ephedra, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix cyathulae, dried lacquer, the root of Chinese clematis, the seed of cowherb, trigone, cowherb Art, Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Angelicae Sinensis, the fleece-flower root, radices trichosanthis, monkshood, campanulaceae, the tuber of pinellia, smilax, glutinous rehmannia, Radix Notoginseng, rhizoma anemarrhenae and red Chinese herbaceous peony.
2. according to claim 1 a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the Chinese traditional medicine composition Object includes the traditional Chinese medicinal components of following parts by weight:
3 ~ 12 parts by weight of cimicifugae foetidae；
10 ~ 40 parts by weight of Rhizoma Et Radix Notopterygii；
3 ~ 12 parts by weight of Radix Angelicae Pubescentis；
5 ~ 25 parts by weight of the root of Dahurain angelica；
3 ~ 12 parts by weight of ramulus cinnamomi；
10 ~ 40 parts by weight of Chinese ephedra；
5 ~ 25 parts by weight of Radix Salviae Miltiorrhizae；
5 ~ 30 parts by weight of Rhizoma Chuanxiong；
10 ~ 40 parts by weight of radix cyathulae；
5 ~ 25 parts by weight of dried lacquer；
5 ~ 30 parts by weight of the root of Chinese clematis；
3 ~ 18 parts by weight of the seed of cowherb；
5 ~ 30 parts by weight of trigone；
5 ~ 20 parts by weight of curcuma zedoary；
10 ~ 40 parts by weight of Radix Astragali；
5 ~ 30 parts by weight of Rhizoma Atractylodis Macrocephalae；
5 ~ 30 parts by weight of Poria cocos；
10 ~ 40 parts by weight of Radix Angelicae Sinensis；
5 ~ 25 parts by weight of the fleece-flower root；
5 ~ 30 parts by weight of radices trichosanthis；
5 ~ 25 parts by weight of monkshood；
10 ~ 40 parts by weight of campanulaceae；
5 ~ 30 parts by weight of the tuber of pinellia；
3 ~ 18 parts by weight of smilax；
5 ~ 30 parts by weight of glutinous rehmannia；
3 ~ 18 parts by weight of Radix Notoginseng；
5 ~ 30 parts by weight of rhizoma anemarrhenae；
3 ~ 18 parts by weight of RADIX PAEONIAE RUBRA.
3. according to claim 2 a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the Chinese traditional medicine composition Object includes the traditional Chinese medicinal components of following parts by weight:
3 ~ 9 parts by weight of cimicifugae foetidae；
15 ~ 30 parts by weight of Rhizoma Et Radix Notopterygii；
3 ~ 9 parts by weight of Radix Angelicae Pubescentis；
6 ~ 18 parts by weight of the root of Dahurain angelica；
3 ~ 9 parts by weight of ramulus cinnamomi；
15 ~ 30 parts by weight of Chinese ephedra；
6 ~ 18 parts by weight of Radix Salviae Miltiorrhizae；
10 ~ 20 parts by weight of Rhizoma Chuanxiong；
15 ~ 30 parts by weight of radix cyathulae；
6 ~ 18 parts by weight of dried lacquer；
3 ~ 20 parts by weight of the root of Chinese clematis；
5 ~ 15 parts by weight of the seed of cowherb；
10 ~ 20 parts by weight of trigone；
10 ~ 20 parts by weight of curcuma zedoary；
15 ~ 30 parts by weight of Radix Astragali；
10 ~ 20 parts by weight of Rhizoma Atractylodis Macrocephalae；
10 ~ 20 parts by weight of Poria cocos；
10 ~ 30 parts by weight of Radix Angelicae Sinensis；
6 ~ 18 parts by weight of the fleece-flower root；
10 ~ 20 parts by weight of radices trichosanthis；
6 ~ 18 parts by weight of monkshood；
5 ~ 25 parts by weight of campanulaceae；
10 ~ 20 parts by weight of the tuber of pinellia；
5 ~ 15 parts by weight of smilax；
10 ~ 20 parts by weight of glutinous rehmannia；
5 ~ 15 parts by weight of Radix Notoginseng；
10 ~ 20 parts by weight of rhizoma anemarrhenae；
5 ~ 15 parts by weight of RADIX PAEONIAE RUBRA.
4. according to claim 3 a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the Chinese traditional medicine composition Object includes the traditional Chinese medicinal components of following parts by weight:
5 parts by weight of cimicifugae foetidae；
20 parts by weight of Rhizoma Et Radix Notopterygii；
5 parts by weight of Radix Angelicae Pubescentis；
12 parts by weight of the root of Dahurain angelica；
5 parts by weight of ramulus cinnamomi；
20 parts by weight of Chinese ephedra；
12 parts by weight of Radix Salviae Miltiorrhizae；
15 parts by weight of Rhizoma Chuanxiong；
20 parts by weight of radix cyathulae
12 parts by weight of dried lacquer；
15 parts by weight of the root of Chinese clematis；
10 parts by weight of the seed of cowherb；
15 parts by weight of trigone；
10 parts by weight of curcuma zedoary；
20 parts by weight of Radix Astragali；
15 parts by weight of Rhizoma Atractylodis Macrocephalae；
15 parts by weight of Poria cocos；
20 parts by weight of Radix Angelicae Sinensis；
12 parts by weight of the fleece-flower root；
15 parts by weight of radices trichosanthis；
12 parts by weight of monkshood；
25 parts by weight of campanulaceae；
15 parts by weight of the tuber of pinellia；
10 parts by weight of smilax；
15 parts by weight of glutinous rehmannia；
10 parts by weight of Radix Notoginseng；
15 parts by weight of rhizoma anemarrhenae；
10 parts by weight of RADIX PAEONIAE RUBRA.
5. according to any one of claims 1 to 4 a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that The Chinese medicine composition is exterior-applied formulation, and the exterior-applied formulation includes by any one in immersion, attaching, spraying and sprinkling The Chinese medicine composition is applied to patient chest and back by kind insecticide-applying way.
6. according to claim 5 a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the Chinese traditional medicine composition The traditional Chinese medicinal components that object includes are corresponding Chinese medicine raw medicine respectively through supercritical CO2Extract the Chinese medical extract obtained.
7. according to claim 6 a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the Chinese traditional medicine composition Object further includes medicinal material and pharmaceutically acceptable auxiliary material, and the auxiliary material includes gelling agent, moisturizer, preservative, antioxidant, emulsification Agent, thickener, any one or a few in skin penetration enhancer.
8. according to claim 7 a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the exterior-applied formulation For patch, the Chinese medicine composition is mixed with the auxiliary material to be attached on papery or cloth substrate.
9. according to claim 8 a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the auxiliary material includes Gelling agent, the gelling agent include xanthan gum and sodium carboxymethylcellulose, the xanthan gum and the sodium carboxymethylcellulose Weight ratio is 10:1 ~ 1:1.
10. according to claim 8 a kind of for treating the Chinese medicine composition of lung cancer, which is characterized in that the accessory package Include moisturizer, the moisturizer is glycerol, and the weight ratio of the glycerol and the gelling agent is 10:1 ~ 4:1.
CN201811141154.7A 2018-09-28 2018-09-28 It is a kind of for treating the Chinese medicine composition of lung cancer Pending CN109248297A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103191191A (en) * 2013-04-20 2013-07-10 杨凌无为制药集团有限公司 Preparation method of traditional Chinese medicine composition for treating advanced non-small cell lung cancers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103191191A (en) * 2013-04-20 2013-07-10 杨凌无为制药集团有限公司 Preparation method of traditional Chinese medicine composition for treating advanced non-small cell lung cancers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张然丁，张维博: "《张然丁肿瘤医案选及影像诊断》", 31 January 2017, 山西科学技术出版社 *

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