CN106109718A

CN106109718A - A kind of External-applicationtraditional traditional Chinese medicinal treating lower limb lymphedema

Info

Publication number: CN106109718A
Application number: CN201610672448.7A
Authority: CN
Inventors: 赵卫东; 侯燕; 赵旖旎
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-08-16
Filing date: 2016-08-16
Publication date: 2016-11-16

Abstract

A kind of External-applicationtraditional traditional Chinese medicinal treating lower limb lymphedema, relate to the field of Chinese medicines, it includes the raw material of following component, is by weight: Natrii Sulfas 1900 ~ 2100g, Borneolum Syntheticum 18 ~ 22g, Radix Et Rhizoma Rhei 18 ~ 22g, Rhizoma Coptidis 18 ~ 22g, Cortex Phellodendri 18 ~ 22g, Herba Artemisiae Annuae 13 ~ 17g, Flos Buddlejae 13 ~ 17g, Xi 13 ~ 17g, Folium Nandinae domesticae 13 ~ 17g, Radix Phytolaccae 13 ~ 17g, Flos Genkwa 8 ~ 12g, dish 8 ~ 12g, Radix Zanthoxyli Avicennae 8 ~ 12g, Radix Kansui 8 ~ 12g.The present invention directly acts on affected part, there is the effects such as diaphoresis, diuresis, removing water retention by purgation, reduce water retention, have and improve blood circulation, promote absorption and the machine of edema, endocrine regulation systems etc. act on, medicine by Cutaneous permeation to subcutaneous tissue, produces the relative potence of drug level in affected part in local, alleviates the inflammatory reaction of local, promote the tissue fluid circulation of local, reach to eliminate the purpose of edema.

Description

A kind of External-applicationtraditional traditional Chinese medicinal treating lower limb lymphedema

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to a kind of External-applicationtraditional traditional Chinese medicinal treating lower limb lymphedema.

Background technology

Edema be due to ailment said due to cold or exposure, heresy that sore, water are wet is outer attacks, eating and drinking without temperance, innate deficiency, prolonged illness overstrain, causes internal Water retention, spreads unchecked skin, and show eyelid, head, extremity, that abdomen carries on the back the class that even anasarca is main clinical characteristics is sick Card.The basic pathogenesis of edema be lung lose logical adjust, spleen lose open entire, qiactivity of triple energizer is unfavorable, water retention.Lower limb lymphedema many because of Damp and hot heresy dipping skin, multiple abscess lower limb, or insufficiency of the spleen water retention, wet hold back mechanism of qi, it is swollen for causing QI and blood blocking barrier, excessive of water Tianjin Swollen.The course of disease is remote, healthy energy damage, blood stasis due to qi deficiency, obstruction of collaterals by blood stasis then sends out the diseases such as skin is coarse, hard.

Lower limb lymphedema be lymph fluid reflux obstacle, make lymph fluid subcutaneous tissue accumulation and cause fibroplasia, Adiposclerosis, later stage limb swelling, and also pachyderma, coarse, hard such as Corium elephatis.The western medical treatment method of lower limb lymphedema Having non-operative treatment and operative therapy, non-operative treatment includes lifting affected limb, wears stretch socks, restriction water salt absorption, use diuresis Agent, prevention are infected and binding therapy, and operation method includes whole bark excision+skin grafting, dermal skin flap Burying, Pedunculated greater omentum Transplantation, lymphatic vessel-anastomosis of veins or lymph node-anastomosis of veins.Lower limb lymphedema is as one clinically often See disease, frequently-occurring disease, there is no curative effect at present and preferably treat the Traditional Chinese Medicine for external application of lower limb lymphedema.

Summary of the invention

The invention provides a kind of External-applicationtraditional traditional Chinese medicinal treating lower limb lymphedema, its effective ingredient is rapid By pore, skin absorption, eliminate lower limbs edema, and ingredient is without liver, portal system, it is to avoid the head of liver Cross effect, decrease the generation of untoward reaction.

The technical solution used in the present invention is: the External-applicationtraditional traditional Chinese medicinal of a kind for the treatment of lower limb lymphedema, bag Include the raw material of following component, be by weight: Natrii Sulfas 1900 ~ 2100g, Borneolum Syntheticum 18 ~ 22g, Radix Et Rhizoma Rhei 18 ~ 22g, Rhizoma Coptidis 18 ~ 22g, Huang Cypress 18 ~ 22g, Herba Artemisiae Annuae 13 ~ 17g, Flos Buddlejae 13 ~ 17g, Xi 13 ~ 17g, Folium Nandinae domesticae 13 ~ 17g, Radix Phytolaccae 13 ~ 17g, Flos Genkwa 8 ~ 12g, dish 8 ~ 12g, Radix Zanthoxyli Avicennae 8 ~ 12g, Radix Kansui 8 ~ 12g.

A kind of External-applicationtraditional traditional Chinese medicinal for the treatment of lower limb lymphedema, optimum ratio, former including following component Material, be by weight: Natrii Sulfas 2000g, Borneolum Syntheticum 20g, Radix Et Rhizoma Rhei 20g, Rhizoma Coptidis 20g, Cortex Phellodendri 20g, Herba Artemisiae Annuae 15g, Flos Buddlejae 15g, Xi 15g, Folium Nandinae domesticae 15g, Radix Phytolaccae 15g, Flos Genkwa 10g, dish 10g, Radix Zanthoxyli Avicennae 10g, Radix Kansui 10g.

A kind of External-applicationtraditional traditional Chinese medicinal for the treatment of lower limb lymphedema, optimum ratio, former including following component Material, be by weight: Natrii Sulfas 1900g, Borneolum Syntheticum 18g, Radix Et Rhizoma Rhei 18g, Rhizoma Coptidis 18g, Cortex Phellodendri 18g, Herba Artemisiae Annuae 13g, Flos Buddlejae 13g, Xi 13g, Folium Nandinae domesticae 13g, Radix Phytolaccae 13g, Flos Genkwa 8g, dish 8g, Radix Zanthoxyli Avicennae 8g, Radix Kansui 8g.

A kind of External-applicationtraditional traditional Chinese medicinal for the treatment of lower limb lymphedema, optimum ratio, former including following component Material, be by weight: Natrii Sulfas 2100g, Borneolum Syntheticum 22g, Radix Et Rhizoma Rhei 22g, Rhizoma Coptidis 22g, Cortex Phellodendri 22g, Herba Artemisiae Annuae 17g, Flos Buddlejae 17g, Xi 17g, Folium Nandinae domesticae 17g, Radix Phytolaccae 17g, Flos Genkwa 12g, dish 12g, Radix Zanthoxyli Avicennae 12g, Radix Kansui 12g.

Usage and dosage: weighting raw materials by weight, pulverizes and mixes, and loads in cloth bag and is directly externally applied to suffering limb, every 24 little Shi Genghuan once, 1 week is a course for the treatment of.

In the present invention, each composition herbal pharmacology is as follows:

Natrii Sulfas (Natrii Sulfas), another name: Mirabilitum, Mirabilitum, air slaking nitre.Source: Sulfates mineral Natrii Sulfas race Natrii Sulfas Mirabilite, processed refined crystalline solid.Main component: the main sodium Han aqueous sulfuric acid, and be often mingled with trace sodium chloride, The impurity such as calcium sulfate and magnesium sulfate.This product is permeability purgatives medicine, forms hypertonic salt solution state, promote intestinal after being administered orally in intestinal Wriggle and diarrhea inducing in road.Prescription based on Natrii Sulfas has significant antiinflammatory, antibacterial and dissolving cholelithiasis effect.Medicinal Materials Characters: prism Shape, rectangle or irregularly crystallize, two ends are irregular, not of uniform size.Water white transparency, there is straight rib on surface, then table in exposure air Face gradually air slaking and cover one layer of white powder.Tool hyaloid gloss.Matter is crisp, frangible, streak white.Fracture is irregular.Odorless, taste Bitter, salty.Meridian distribution of property and flavor: cold in nature, salty in the mouth, hardship.Return stomach warp, large intestine channel.Effect and effect: purging heat to relax the bowels, moistening for dryness and softening hard mass, relieving inflammation or internal heat disappears Swollen.Belong to the cathartic drug of purgatives medicine subordinate classification.Clinical practice: consumption 6～12 grams, does not the most enter decoct, until decoction decoct after, molten Enter in decoction and take；Suitable amount used externally.With controlling excess-heat constipation, constipation due to dry stool, stagnant stomachache, acute appendicitis swell and ache, acute mastitis, swelling and pain of hemorrhoid. Use taboo: should not use same with Rhizoma Sparganii, anemia of pregnant woman disable.

Borneolum Syntheticum (Borneolum Syntheticum), another name: Borneolum Syntheticum, Blumeae preparatum Tabellae, Bigpian.Source: feverfew Herba Blumeae Balsamiferae The leaf of Blumea balsamifera. DC. crystallizes in extract, practises and claim " Blumeae preparatum Tabellae ".Spore density Borneolum Syntheticum The processed goods of Dryobalanops aromatica Gaertn.f. resin, practises and claims " borneol ".Except this, synthetic ice Sheet, also known as " BORNEOLUM SYNTHETICUM " or " Bigpian ", is through being chemically synthesized with Camphora, Oleum Terebinthinae etc..Main component: topical application pair Sensory nerve has slight stimulation, has certain pain relieving and antisepsis；Blood brain barrier can be run through after clothes enter Nerve centre plays a role；Can significantly extend mouse sleep time and pentobarbital generation synergism that pentobarbital causes, And mice hypoxia endurance time can be extended；The Borneolum Syntheticum (0.5%) of higher concentration has inhibitory action to various bacteria；Centering, late pregnancy Mice has induced labor effect.Medicinal Materials Characters: translucent crystallization, diameter 2 ~ 8 millimeters, thick 2 ~ 3 millimeters, white.Gas delicate fragrance, acrid in the mouth is cool dense Strong.After distillation, form translucent bulk, flaky crystal.Combustion have dark smoke.Meridian distribution of property and flavor: cold in nature, acrid in the mouth, hardship.GUIXIN Warp, spleen channel, lung meridian.Effect and effect: refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Belong to awaking drug.Clinical practice: consumption 0.03 ~ 0.1 gram.Outward With in right amount.With closing in controlling heat-blockage coma, expectorant heat, summer-heat soldier faints, infantile convulsion and various sore, carbuncle and painful swelling, burst after do not hold back, burn and scald, Laryngopharynx swelling and pain, sore throat, conjunctival congestion and swelling pain, aphtha of the mouth and tongue etc..Use taboo: anemia of pregnant woman is cautious use of.

Radix Et Rhizoma Rhei (Rhei Radix Et Rhizoma), another name: general, RADIX ET RHIZOMA RHEI OFFICILALIS, cow tongue Radix Et Rhizoma Rhei.Source: polygonaceae plant Sorrel Rheum palmatum, L., Rheum tanguticum Rheum tanguticum Maxim. ex Balf. or medicinal are greatly The dry root of yellow Rheumoj-flcinale Baill. and rhizome.Main component: this product mainly containing aloe-emodin, chrysophanol, The compositions such as physcione, chrysophanic acid, rheum emodin.Medicinal Materials Characters: class is cylindrical, cone, oval or irregularly block, long 3 ~ 17 centimetres, diameter 3 ~ 10 centimetres.Ex-all crust person surface yellowish-brown to rufous, the visible off-white color reticular texture having, residual The crust sepia stayed, many tool cord hole and thick wrinkle.Matter is solid, and some centers are the softest, the light red brown of section or yellowish-brown, aobvious Graininess；Rhizome marrow broadness has punctate opacity of the cornea circular row or is dispersed in；Root woody part is flourishing, has radial texture, and cambium layer is obvious, without star Point.Gas delicate fragrance, bitter in the mouth and micro-puckery, that chews sticks to one's teeth, and has grains of sand sense.Meridian distribution of property and flavor: cold in nature, bitter in the mouth.Return spleen channel, stomach warp, large intestine channel, Liver Channel, pericardium channel.Effect and effect: purging heat to relax the bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Belong to the cathartic drug of purgatives medicine subordinate classification.Face Bed application: consumption 3 ~ 30 grams, decoction.With controlling that excess-heat constipation, stagnant stomachache, dysentery be not well, jaundice due to damp-heat, heat in blood tell nosebleed, conjunctival congestion, Pharyngeal swelling, acute appendicitis furuncle, blood stasis amenorrhea, traumatic injury.Suitable amount used externally, controls burn due to hot liquid or fire, upper gastrointestinal hemorrhage.Use taboo: all Exterior syndrome is not stopped, and blood deficiency gas is weak, Deficiency and coldness of spleen and stomach, without before excess-heat, stagnant, stasis, and tire, puerperal, will careful take, Radix Et Rhizoma Rhei takes orally It may happen that the side reaction such as Nausea and vomiting, stomachache, can alleviate after general drug withdrawal.

Rhizoma Coptidis (Coptidis Rhizoma), another name: Rhizoma Coptidis, Wang Lian, taste company, Rhizoma Coptidis, Rhizoma Coptidis.Source: Ranunculaceae is planted The rhizome of thing Rhizoma Coptidis Coptis chinensis Franch..Main component: containing berberine, and containing coptisine, 13-methyl-.psi.-coptisine., Palmatine, berberrubine, epiberberine, coptisine, palmatine, jateorhizine etc..Huang can be differentiated with hydrogen nuclear magnetic resonance spectroscopy The true and false even.Berberine is principle active component in Rhizoma Coptidis.Medicinal Materials Characters: gather cluster, often bends more, shape such as chicken feet, Dan Zhi Rhizome length 3～6 centimetres, diameter 0.3～0.8 centimetre.Surface lark or yellowish-brown, coarse, there are irregular nodular pattern protuberance, palpus Root and fibrous root residue, some internode left sides are smooth such as stem stalk, habit title " gap bridge ".Top many residuals brown scale leaf, top is often left Remaining stem or petiole.Matter is hard, and section is irregular, and skin zone is orange red or burgundy, woody part foresythia or orange-yellow, radially Arrangement, the hollow that marrow has.Feeble QI, taste is the most bitter.Meridian distribution of property and flavor: cold in nature, bitter in the mouth.GUIXIN warp, spleen channel, stomach warp, Liver Channel, gallbladder meridian, Large intestine channel.Effect and effect: heat clearing and damp drying, eliminating fire and detoxication.Belong to the heat clearing and dampness removing medicine of antipyretic subordinate classification.Clinical practice: use Measure 2～5 grams, decoction.With controlling damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, heat in blood tell nosebleed, mesh Red, have a toothache, quench one's thirst, carbuncle furuncle.Suitable amount used externally, controls eczema, eczema, auditory meatus are suppurated.Use taboo: insufficiency of stomach vomiting and nausea, insufficiency of the spleen let out Rush down, just before dawn the kidney person of rushing down, the most careful clothes.

Cortex Phellodendri (Phellodendri Chinensis Cortex), another name: Cortex Phellodendri, bark of amur corktree, Cortex clausenae lansii.Source: The bark of rutaceae wampee Phellodendron chinense Schneid..Main component: containing berberine, and contain The multiple alkaloid such as magnoline, phellodendrine and lactone, sterol, lymphatic temperament etc..Pharmacological evaluation shows, has antibacterial, hypotensive effect. It addition, central nervous system there to be inhibitory action, and pancreatic secretion there is facilitation.Medicinal Materials Characters: en plaque or shallow slot shape, Length and width differ, thick 3 ~ 6 millimeters.Outer surface yellowish-brown or yellowish-brown, smooth or tool longitudinal furrow stricture of vagina, the visible hole skin trace having and remaining Taupe rough bark.Inner surface dark yellow or light brown, have fine and closely woven vertical rib.Body is light, and matter is hard, and section fibrous, in splintery Layering, buff.Feeble QI, taste is the most bitter, and that chews has stickiness.Meridian distribution of property and flavor: cold in nature, bitter in the mouth.Return kidney channel, bladder warp.Effect and work With: heat clearing and damp drying, pathogenic fire purging are except steaming, detoxification sore treatment.Belong to the heat clearing and dampness removing medicine of antipyretic subordinate classification.Clinical practice: consumption 3 ~ 12 Gram, decoction or enter ball dissipate；Suitable amount used externally, grinds into powder and dresses or decoct water retting affected part.With control damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, Hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission；Sore swollen toxin, eczema pruritus.Use taboo: diarrhea due to hypofunction of the spleen, stomach weak lack of appetite person avoids clothes.

Herba Artemisiae Annuae (Artemisiae Annuae Herba), another name: grass Artemisia, smelly Artemisia, smelly Herba Artemisiae Annuae, Conyza bonariensis (L.) Crong., wine cake grass.Come Source: the aerial parts of feverfew Herba Artemisiae annuae Artemisia annuaL.Main component: main containing multiple sesquiterpene lactones, flavone Class, Coumarins, volatile oil etc..Another containing arteannuin, artemisinol, artelinic acid, methyl arteannuate, Quercetin, fenchone, artemisia The compositions such as coumarin.Medicinal Materials Characters: stem is cylindrical, top multi-branched；Surface yellow green or brown color, the vertical crest line of tool；Matter is slightly hard, Frangibility, has marrow in the middle part of section.Leaf alternate, dirty-green or brown-green, crispatura frangible, and complete person is 3 times pinniform drastic cracks after flattening, Sliver and lobelet square be circular or oblong, and two sides is by undercoat.Gas perfume (or spice) is special, mildly bitter flavor.Meridian distribution of property and flavor: cold in nature, bitter in the mouth, Pungent.Return gallbladder meridian, Liver Channel.Effect and effect: heat-clearing and toxic substances removing, except hectic fever due to YIN-deficiency, preventing the attack (or recurrence) of malaria.Belong to the deficient heat clearing drug of classification under antipyretic.Clinical Application: consumption 6～12 grams, decoction, enter decoct preferably after under.With control epidemic febrile disease, summer-heat, hectic fever due to YIN-deficiency consumptive fever, pathogenic summer-heat heating, malaria, dysentery, Fever due to yin deficiency, skin ulcer are itched, jaundice due to damp-heat etc..Use taboo: puerperal blood deficiency, endogenous cold rushes down, and the retention of food and drink person of having loose bowels, and does not use.

Flos Buddlejae (Buddlejae Flos), another name: old Flos Buddlejae, Shui Jinhua, sheep spring bar, yellow meal flower, Flos Buddlejae, Oryza glutinosa Flower.Source: the alabastrum of loganiaceae plant Flos Buddlejae Buddleja officinalis Maxim. and inflorescence thereof.Main component: contain The compositions such as Flos Buddlejae glycosides, buddleo-glucoside, Syring vulgaris phenolic glycoside, Flos Buddlejae glycosides A, Flos Buddlejae glycosides B.Medicinal Materials Characters: mostly be alabastrum close poly- Inflorescence branchlet, in irregular roundness taper, long 1.5～3 centimetres.Surface lark or brown color, close by fine hair.Alabastrum is short Bar-shaped, upper end is bigger, long 0.3～0.1 centimetre, diameter 0.1～0.2 centimetre；Calyx mitriform, tip 4 fissure；Corolla tubular, with Calyx is isometric or the longest, and tip 4 splits, and sliver is avette；4 pieces of stamen, raw in the middle part of corolla pipe.Matter is soft.Feeble QI is fragrant, mildly bitter flavor, Pungent.Meridian distribution of property and flavor: cold nature, sweet in the mouth.Return Liver Channel.Effect and effect: heat clearing away nourishing the liver pathogenic fire purging, improving acuity of vision and removing nebula.Belong to antipyretic subordinate The heat clearing and fire purging medicine of classification.Clinical practice: consumption 3～9 grams, is decocted in water for oral dose.With controlling conjunctival congestion and swelling pain, many tear photophobia, nebula of looking unfamiliar film, liver Empty mesh is dark, blurring of vision.Use taboo: mesh disease belongs to the yang deficiency careful clothes of endogenous cold person.

Xi (Thlaspi Herba), another name: big shepherd's purse, floral leaf shepherd's purse, Lao Gucao, HERBA THALASPIS, folding loud, high-pitched sound (Tibetan name).Source: The dry aerial parts (band seed) of crucifer Xi Thlaspi arvetse L..Main component: seed contains black mustard Glycoside, sinigrin, potassium myronate generates different sulphuric acid propylene, lecithin, myosin enzyme after enzyme hydrolysis.And fatty oil, leaf, All containing vitamin C in root, fruit.Another containing compositions such as volatile oil (mustard oil), protein, sucrose, lecithin and myrosases.Medical material Shape: stem is cylinder, long 20～40 centimetres, diameter 0.2～0.5 centimetre；Surface yellow green or lark, have thin vertical crest line；Matter Crisp, frangibility, section marrow white.Leaf alternate, lanceolar, base portion leaf mostly is down lanceolar, comes off more.Total shape infructescence is born in stem Branch top and axil, fruit oval and flat, diameter 0.5～1.3 centimetres；Surface lark or celadon, center swells, There is wing at edge, wide about 0.2 centimetre, is respectively arranged with 1 vertical crest line in the middle of two sides, and first concave end, base portion has thin carpopodium, is about 1 centimetre；Really Point Room 2 in real, there are mediastinum film, every room seed 5～7 in centre.The flat oval of seed.Feeble QI, lightly seasoned.Meridian distribution of property and flavor: cold nature, Acrid in the mouth.Return Liver Channel, stomach warp, large intestine channel.Effect and effect: liver heat removing and eyesight improving, and middle dampness removing, removing toxic substances and promoting subsidence of swelling.Belong under damp-clearing drug Belong to the edema-alleviating diuretic of classification.Clinical practice: consumption 9～15 grams, fresh goods doubles.Treatment conjunctival congestion and swelling pain, abdominal distention, hypochondriac pain, Acute appendicitis, edema, leukorrhagia, furuncle carbuncle.Use taboo: be still not clear.

Folium Nandinae domesticae (Nanadinae Folium), another name: mao bamboo leaf, sky Folium Bambusae.Source: Berberidaceae plant Fructus Nandinae Domesticae The dried leaves of Nandina domestica Thunb..Main component: mainly containing magnoflorine, vitamin C, Fructus Nandinae Domesticae cyanogen glycosides, The compositions such as amentoflavone, Fructus Nandinae Domesticae glycosides A.Medicinal Materials Characters: leaf is two to three times winglike compound leaves, the pinnule of most end has lobule 3～5 pieces, lobule ellipticity lanceolar, long 3～10 centimetres, wide 0.5～1 centimetre, tip is tapering, base portion wedge shape, Quan Yuan, surface Bottle green or redness.Keratin.Feeble QI, bitter in the mouth.Meridian distribution of property and flavor: cold in nature, bitter in the mouth.Gui Jingwu.Effect and effect: clearing away heat-damp and promoting diuresis, rush down Fire, removing toxic substances.Belong to the heat clearing and fire purging medicine of classification under antipyretic.Clinical practice: for oral administration: decoct soup, consumption 9～15 grams.External: appropriate, Mash coating, or decoct washing.Cure mainly cough due to lung-heat, pertussis, pyretic stranguria, hematuria, conjunctival congestion and swelling pain, carbuncle sore, scrofula.Use and avoid: It is still not clear.

Radix Phytolaccae (Phytolaccae Radix), another name: RADIX PHYTOLACCAE, JIANZHONGXIAO, Radix Phytolaccae, Radix phytolaccae.Source: Phytolaccaceae The root of plant pokeweed Phytolacca acinosa Roxb..Main component: containing esculentoside E, phytolaccatoxin, alkaloid, △ '-stigmasterol, hitodesterol, Radix Phytolaccae kind glycosides A, Radix Phytolaccae kind glycosides B, Radix Phytolaccae kind glycosides C, Radix Phytolaccae kind glycosides D, pokeroot saponin A, Radix Phytolaccae Plant the compositions such as acid, Radix Phytolaccae kind aglycon, the acid of 2-hydroxyl Radix Phytolaccae kind, Radix seu Folium Phytolaccae americanae toxin, Radix seu Folium Phytolaccae americanae glycosides E, esculentoside.Medicinal Materials Characters: Crosscutting or the irregular block sheet of rip cutting, thickness.Crust lark or taupe brown.Transverse section bending injustice, edge shrinkage, directly Footpath 2～8 centimetres；Tangent plane light yellowish brown or yellow-white, woody part is swelled, and forms the proper alignment ring wheel of several projection.Longitudinal section bends Or curling, long 5～8 centimetres, wide 1～2 centimetre, woody part is equality strip projection.Matter is hard.Feeble QI, taste is micro-sweet, chews fiber crops tongue for a long time.Property Taste return through: cold in nature, bitter in the mouth.Poisonous.Return lung meridian, spleen channel, kidney channel, large intestine channel.Effect and effect: relieve oedema or abdominal distension through diuresis or purgation detumescence, smoothening secretion, solution Poison eliminating stagnation.Belong to the drastically purgating water drug of purgatives medicine subordinate classification.Clinical practice: consumption 3～9 grams, decocts soup and takes orally.With swelling of harnessing the river Full, constipation and anuresis；Suitable amount used externally, fresh goods is mashed or dry product grinds coating affected part into powder, with controlling carbuncle sore tumefacting virus.Use and avoid: insufficiency of the spleen water Swell and be not taken by pregnant women.Preferably from the beginning of in a small amount.This product has a stimulation to gastrointestinal tract, therefore preferably taking medicine after meal.Excess poisoning, may occur in which evil The heart is vomitted, abdominal pain diarrhea, tachycardia, breathes frequency, and continue then slurred speech, restless, twitches, severe patient blood pressure drops, stupor, Platycoria, heart beating or respiratory arrest and dead.

Flos Genkwa (Genkwa Flos), another name: Yuan, red Yuan, Yuan barriness, lose flower, headache flower, Flos syringae persicae flower.Source: winter daphne The dry flower of section plant Flos Genkwa Daphne genkwa Sieb.et Zucc..Main component: flower and alabastrum ortho esters Han diterpene Compounds, flavone compound, containing abundant fatty acid in volatile oil, Palmic acid, oleic acid and linoleic acid content are higher, account for total The 60% of oil mass.Another containing compositions such as Flos Genkwa ester, genkwanol, genkwanin, daphnetin, lariciresinols.Medicinal Materials Characters: normal 3～7 Bunch being born on short floral axis, base portion has bract 1～2, comes off for single more.Dan Duocheng wooden club shape, bends more, long 1～1.7 li Rice, diameter about 1.5 millimeters, perianth tube surface lavender or celadon, close by pubescence, tip 4 splits, sliver lavender or yellowish-brown Color, matter is soft.Feeble QI, sweet in the mouth, micro-pungent.Meridian distribution of property and flavor: warm in nature, bitter in the mouth, pungent.Return lung meridian, spleen channel, kidney channel.Effect and effect: removing water retention by purgation By drink, external parasite killing treats skin ulcer.Belong to the drastically purgating water drug of purgatives medicine subordinate classification.Clinical practice: consumption 1.5～3 grams.Stir-baked FLOS GENKWA with vinegar grinds End is swallowed, one time 0.6～0. 9 gram, 1 time on the one.Suitable amount used externally., chest and abdomen hydrops, phlegm retention accumulation full with swelling of harnessing the river, QI rising in reverse order are coughed Breathe heavily, difficulty in urination and defecation, external treatment scabies tinea alba, carbuncle, chilblain.Use taboo: have a delicate constitution, or have adverse cardiac, Peptic Ulcers, disappear Change gastrointestinal hemorrhage and anemia of pregnant woman prohibits clothes；Consumption is preferably light, is gradually increased, and middle disease is i.e. stopped, and can not take for a long time.Should not be with Radix Glycyrrhizae with using.

Dish (Herba Rorippae), another name: sarson, wild mustard grass, Du Gencai.Source: crucifer dish The dry herb of Rorippa indica (L.) Hiern.Main component: this product is mainly containing dish element, organic acid, flavonoid The composition such as compound and Alkaloid.Medicinal Materials Characters: this product is irregular section, root, stem, leaf, flower, fruit mixing, root is elongated, table Face is faint yellow, has irregular longitudinal grin；Matter is crisp, frangibility；Section skin zone off-white color, woody part yellow.Stem is very thin, the vertical wrinkle of tool, table Face light green or band purple.Leaf is crispaturaed more, broken, and complete person is the most avette in oblong after flattening, blade the biggest head plumage Splitting, long 5～7 centimetres, wide 1～2.5 centimetre, top sliver is relatively big, and edge has irregular sawtooth, yellow green.The total shape of inflorescence, flower Little, yellow.Angle fruit is thin circular, bronzing, and seed is most.Feeble QI, lightly seasoned.Meridian distribution of property and flavor: slightly warm in nature, acrid in the mouth, hardship.Return lung meridian, Liver Channel.Effect and effect: expelling phlegm for arresting cough, relieving exterior syndrome and dispelling cold, promoting blood circulation and detoxication, dampness removing jaundice eliminating.The pungent temperature belonging to diaphoretic medicine subordinate classification solves Medicine administered to bring out the cold.Clinical practice: for oral administration: decocting soup, 10～30 grams, fresh goods doubles；Or smash strand juice clothes.External: appropriate, smashes deposited.Cure mainly cough Phlegm dyspnea, cold, fever, measles without adequate eruption, rheumatic arthralgia, laryngopharynx swelling and pain, furuncle pain is swollen, dermatitis rhus, amenorrhea, and traumatic injury is yellow Subcutaneous ulcer, edema.Use taboo: excessive use may occur in which the phenomenons such as slight xerostomia, stomach discomfort, but does not affect continual cure.

Radix Zanthoxyli Avicennae (Radix Zanthoxyli Avicennae), another name: muscle olive root, seed of Zanthoxylum armatum DC.(Z.Planispinum Sieb.et Zucc.) root, Ramulus Kalopanacis seu Araliae.Source: The root of rutaceae (strangling party) Zanthoxylum avicenn, ae (Lam.) DC..Main component: root bark olive in muscle Alkali, dihydro muscle olive alkali, chelerythrine, nitidine, magnoline, candicine, Teng Bo its times alkali, Hesperidin, Di Aoming, eagle are not Pool lactone alcohol.Medicinal Materials Characters: irregular inclined section is block.Cork buff, coarse, have longitudinal crack, matter is loose, easy to fall off.Remove In yellowish-brown after cork, skin zone is thin, can peel off with woody part, inner surface pitchy, and matter is tough, indulges and tears in threadiness.Woody part is pale yellow in vain Color, matter is solid, and section cambium layer is obvious.Gas is fragrant, and the acrid in the mouth that root bark is chewed is peppery and bitter.Meridian distribution of property and flavor: slightly warm in nature, bitter in the mouth, pungent.Return lung Warp, stomach warp.Effect and effect: dispel the wind detumescence, promoting the circulation of QI to relieve pain, dampness removing jaundice eliminating.Belong to the inducing diuresis to remove edema of damp-clearing drug subordinate classification Medicine.Clinical practice: consumption 9 ~ 15 grams, decoction.By dispelling the wind and dampness pathogens osteodynia, peratodynia, traumatic injury stasis of blood pain, moist edema.Use taboo: pregnant Woman is cautious use of.

Radix Kansui (Kansui Radix), another name: cat's eye, swollen hands flower, headache flower, sweet.Source: euphorbia plant Radix Kansui The tuber of Euphorbia kansui T.N.Liou ex T.P.Wang.Main component: this product contains euphadienol, α-Radix Euphorbiae Pekinensis Alcohol, tirucallol, γ-Radix Cirsii Japonici sterol, tirucallol, α-Radix Cirsii Japonici sterol.Separately having been reported that, root still deoxygenates naboom terpene alcohol containing 20- Derivant (I), (II), the derivant (III) of naboom terpene alcohol, the derivant (IV) of 13-oxidation naboom terpene alcohol, Radix Kansui terpene ester A And Radix Kansui terpene ester B, mentioned component is the most toxic, separately containing cupreol.Medicinal Materials Characters: oval, elongated cylindrical or beaded, long 1～5 centimetre, diameter 0.5～2.5 centimetres.Surface off-white color or yellow-white, recess has brown crust to remain.Matter is crisp, easy to break Disconnected, section mealiness, white, woody part shows radial texture；Oval column person's fibroid is stronger.Feeble QI, taste is micro-sweet and peppery.Nature and flavor are returned Warp: cold in nature, bitter in the mouth.Return lung meridian, kidney channel, large intestine channel.Effect and effect: removing fluid-retention by purgation, dispersing swelling and dissipating binds.Belong to purgatives medicine subordinate classification Drastically purgating water drug.Clinical practice: consumption 0.5～1.5 grams, big gun enters ball more and dissipates use after processing；Suitable amount used externally, raw use.Swollen with harnessing the river The accumulation of distension, chest and abdomen hydrops, phlegm retention, QI rising in reverse order are breathed with cough, difficulty in urination and defecation.Use taboo: poisonous, the deficiency of vital energy, cloudy wound, taste languisher and Anemia of pregnant woman disables, should not be with Radix Glycyrrhizae with using.

In the above-mentioned all medicines of the present invention, with Natrii Sulfas as principal agent, with other all medicines as accessory drugs, Natrii Sulfas and Radix Et Rhizoma Rhei all have cold and cool it Property, all can capture and purge heat, and Natrii Sulfas is longer than softening mass and moistening dryness, and Radix Et Rhizoma Rhei is longer than and cleanses intestinal internal organs, two medicine compatibilities, can strengthen purges heat attack long-pending it Merit, more increases the effect of detumescence of relieving oedema or abdominal distension through diuresis or purgation.Borneolum Syntheticum and Radix Et Rhizoma Rhei all can heat clearing away, Borneolum Syntheticum has the effect of inducing menstruation to relieve menalgia concurrently, and Radix Et Rhizoma Rhei has removing blood stasis solution concurrently The effect of poison, two medicine compatibilities, removing blood stasis is not forgotten to stimulate the menstrual flow, is played the effect of reducing swelling and alleviating pain altogether.It is that main compatibility is big with Rhizoma Coptidis, the Cortex Phellodendri of heat clearing away Yellow descending with heat conduction, the effect of clearing away heat-fire can be strengthened, evanescence of heat water is from disappearing.Herba Artemisiae Annuae, Flos Buddlejae are all cold and cool property with Folium Nandinae domesticae, Herba Artemisiae Annuae heat-clearing and toxic substances removing, Flos Buddlejae heat clearing away nourishing the liver pathogenic fire purging, Folium Nandinae domesticae clearing away heat-damp and promoting diuresis, pathogenic fire purging, removing toxic substances, in addition dish slightly warm in nature, solve Table cold expelling, promoting blood circulation and detoxication, dampness removing jaundice eliminating, four medicine compatibilities strengthen the effect of clearing heat, detoxicating, dispelling dampness.Xi, Radix Phytolaccae and Radix Kansui are all cold in nature Medicine, Xi and middle dampness removing, removing toxic substances and promoting subsidence of swelling, Radix Phytolaccae relieves oedema or abdominal distension through diuresis or purgation detumescence, smoothening secretion, detoxicating and resolving stagnation of pathogens, Radix Kansui removing fluid-retention by purgation, Sweeling-eliminating medicine powder Knot, Flos Genkwa is warm in nature with both Radix Zanthoxyli Avicennaes, Flos Genkwa removing fluid-retention by purgation, and Radix Zanthoxyli Avicennae dispels the wind detumescence, promoting the circulation of QI to relieve pain, and dampness removing jaundice eliminating, all medicines are joined 5 strengthen and middle dampness removing, removing toxic substances and promoting subsidence of swelling, the effect of detumescence of relieving oedema or abdominal distension through diuresis or purgation.

The present invention directly acts on affected part, has the effects such as diaphoresis, diuresis, removing water retention by purgation, reduces water retention, has and change The effects such as kind blood circulation, promotes absorption and the machine of edema, endocrine regulation system, medicine is in affected part by Cutaneous permeation extremely Subcutaneous tissue, produces the relative potence of drug level in local, alleviates the inflammatory reaction of local, promotes that the tissue fluid of local follows Ring, reaches to eliminate the purpose of edema.It is simple that the present invention has manufacturing process, lower cost for material, the feature easily promoted the use of.

Detailed description of the invention

In conjunction with specific embodiment, the present invention is further elaborated:

The technical solution used in the present invention is: a kind for the treatment of lower limb lymphedema External-applicationtraditional traditional Chinese medicinal, including under The raw material of row component, be by weight: Natrii Sulfas 1900 ~ 2100g, Borneolum Syntheticum 18 ~ 22g, Radix Et Rhizoma Rhei 18 ~ 22g, Rhizoma Coptidis 18 ~ 22g, Cortex Phellodendri 18 ~ 22g, Herba Artemisiae Annuae 13 ~ 17g, Flos Buddlejae 13 ~ 17g, Xi 13 ~ 17g, Folium Nandinae domesticae 13 ~ 17g, Radix Phytolaccae 13 ~ 17g, Flos Genkwa 8 ~ 12g, Dish 8 ~ 12g, Radix Zanthoxyli Avicennae 8 ~ 12g, Radix Kansui 8 ~ 12g.

The clinical data of the present invention is as follows with method:

1, clinical data:

Choose 598 example lower limb lymphedema patients, be randomly divided into two groups, wherein treatment group 299 example, matched group 299 example.Comparison In group, male 150 examples, female 149 example；In treatment group, male 152 examples, female 147 example.Use External-applicationtraditional traditional Chinese medicinal of the present invention and other Drug therapy, carries out clinical observation to therapeutic effect, and compares result.

2, Therapeutic Method:

Treatment group: diosmin sheet 0.9g po bid and Aspirin Enteric-coated Tablets 75mg po qn, 0.9%NS 250ml+ compound recipe Radix Salviae Miltiorrhizae Injection 20ml ivdrip qd.Be by weight Natrii Sulfas 1900 ~ 2100g, Borneolum Syntheticum 18 ~ 22g, Radix Et Rhizoma Rhei 18 ~ 22g, Rhizoma Coptidis 18 ~ 22g, Cortex Phellodendri 18 ~ 22g, Herba Artemisiae Annuae 13 ~ 17g, Flos Buddlejae 13 ~ 17g, Xi 13 ~ 17g, Folium Nandinae domesticae 13 ~ 17g, Radix Phytolaccae 13 ~ 17g, Flos Genkwa 8 ~ 12g, dish 8 ~ 12g, Radix Zanthoxyli Avicennae 8 ~ 12g, Radix Kansui 8 ~ 12g pulverize and mix, and load in cloth bag and are directly externally applied to suffering limb, Within every 24 hours, change once, within 1 week, be a course for the treatment of.

Matched group: diosmin sheet 0.9g po bid and Aspirin Enteric-coated Tablets 75mg po qn, 0.9%NS 250ml+ FUFANG DANSHEN ZHUSHEYE 20ml ivdrip qd, 50% magnesium sulfate 500g hot-wet compress suffering limb, each 30 minutes, every day 2 times, 1 week It it is a course for the treatment of.

3, efficacy evaluation:

Judge according to People's Republic of China's traditional Chinese medicine industry standard disease Standardization of diagnosis and curative effect (ZY/T001.1-94): with Within 1 week, it is section observing time, the 2nd, 3,4 week Clinical efficacy comparison:

Curing: edema all disappears, other transference cures, lab testing recovers normal；

Take a turn for the better: edema and other symptoms alleviate, and lab testing has improvement；

Do not heal: edema and other symptoms and lab testing are unchanged.

4, therapeutic outcome:

Group	Number (example)	Cure (example)	Take a turn for the better (example)	Invalid (example)	Cure rate (%)
						Treatment group	299	291	6	2	97.3
Matched group	299	198	95	6	66.2

Being shown by upper table treatment situation, after two groups of patient treatments, clinical total effects is compared, and two groups all effective, but treatment group is cured Rate is substantially better than matched group.

Model case:

Case 1: shut out so-and-so, male, 84 years old, main suit: bilateral lower limbs edema 2 years, increases the weight of 2 months, AD: bilateral lower limb drench Bar edema Tinea Pedis.By weight by Natrii Sulfas 2100g, Borneolum Syntheticum 22g, Radix Et Rhizoma Rhei 22g, Rhizoma Coptidis 22g, Cortex Phellodendri 22g, Herba Artemisiae Annuae 17g, Flos Buddlejae 17g, Xi 17g, Folium Nandinae domesticae 17g, Radix Phytolaccae 17g, Flos Genkwa 12g, dish 12g, Radix Zanthoxyli Avicennae 12g, Radix Kansui 12g pulverize also Mixing, loads and is directly externally applied to suffering limb in cloth bag, within every 24 hours, changes once, and after treating 1 week, lower limbs edema substantially alleviates, and continues Treatment, after 2 weeks, bilateral lower limbs edema is wholly absent.

Case 2: king so-and-so, women, 52 years old, main suit: left lower extremity is red and swollen, 10 days companion's left lower extremity edema of pain 2 days, is admitted to hospital and examines Disconnected: left lower extremity erysipelas lymphedema.Give conventional antiinflammatory treatment, simultaneously by weight by Natrii Sulfas 1900g, Borneolum Syntheticum 18g, Radix Et Rhizoma Rhei 18g, Rhizoma Coptidis 18g, Cortex Phellodendri 18g, Herba Artemisiae Annuae 13g, Flos Buddlejae 13g, Xi 13g, Folium Nandinae domesticae 13g, Radix Phytolaccae 13g, Flos Genkwa 8g, dish 8g, Radix Zanthoxyli Avicennae 8g, Radix Kansui 8g pulverize and mix, and load and are directly externally applied to suffering limb in cloth bag, within every 24 hours, change once, after 1 week Left lower extremity edema is wholly absent.

Case 3: east so-and-so, male, 65 years old, main suit: right lower extremity swelling companion's pain 5 days, increase the weight of 1 day, AD: right Deep venous thrombosis of lower limbs lymphedema.Give the conventional therapies such as anticoagulant, simultaneously by weight by Natrii Sulfas 2000g, Borneolum Syntheticum 20g, Radix Et Rhizoma Rhei 20g, Rhizoma Coptidis 20g, Cortex Phellodendri 20g, Herba Artemisiae Annuae 15g, Flos Buddlejae 15g, Xi 15g, Folium Nandinae domesticae 15g, Radix Phytolaccae 15g, Yuan Flower 10g, dish 10g, Radix Zanthoxyli Avicennae 10g, Radix Kansui 10g pulverize and mix, and load in cloth bag and are directly externally applied to suffering limb, and every 24 hours more Changing once, within 1 week, rear right lower limbs edema substantially alleviates, and continues to observe treatment, and within 3 weeks, rear right lower limbs edema is wholly absent.

Claims

1. the External-applicationtraditional traditional Chinese medicinal treating lower limb lymphedema, it is characterised in that include the raw material of following component, press Weight is: Natrii Sulfas 1900 ~ 2100g, Borneolum Syntheticum 18 ~ 22g, Radix Et Rhizoma Rhei 18 ~ 22g, Rhizoma Coptidis 18 ~ 22g, Cortex Phellodendri 18 ~ 22g, Herba Artemisiae Annuae 13 ~ 17g, Flos Buddlejae 13 ~ 17g, Xi 13 ~ 17g, Folium Nandinae domesticae 13 ~ 17g, Radix Phytolaccae 13 ~ 17g, Flos Genkwa 8 ~ 12g, dish 8 ~ 12g, Radix Zanthoxyli Avicennae 8 ~ 12g, Radix Kansui 8 ~ 12g.

The External-applicationtraditional traditional Chinese medicinal of a kind for the treatment of lower limb lymphedema the most according to claim 1, its feature exists In, including the raw material of following component, it is by weight: Natrii Sulfas 2000g, Borneolum Syntheticum 20g, Radix Et Rhizoma Rhei 20g, Rhizoma Coptidis 20g, Cortex Phellodendri 20g, Herba Artemisiae Annuae 15g, Flos Buddlejae 15g, Xi 15g, Folium Nandinae domesticae 15g, Radix Phytolaccae 15g, Flos Genkwa 10g, dish 10g, Radix Zanthoxyli Avicennae 10g, Radix Kansui 10g.

The External-applicationtraditional traditional Chinese medicinal of a kind for the treatment of lower limb lymphedema the most according to claim 1, its feature exists In, including the raw material of following component, it is by weight: Natrii Sulfas 1900g, Borneolum Syntheticum 18g, Radix Et Rhizoma Rhei 18g, Rhizoma Coptidis 18g, Cortex Phellodendri 18g, Herba Artemisiae Annuae 13g, Flos Buddlejae 13g, Xi 13g, Folium Nandinae domesticae 13g, Radix Phytolaccae 13g, Flos Genkwa 8g, dish 8g, Radix Zanthoxyli Avicennae 8g, Radix Kansui 8g.

The External-applicationtraditional traditional Chinese medicinal of a kind for the treatment of lower limb lymphedema the most according to claim 1, its feature exists In, including the raw material of following component, it is by weight: Natrii Sulfas 2100g, Borneolum Syntheticum 22g, Radix Et Rhizoma Rhei 22g, Rhizoma Coptidis 22g, Cortex Phellodendri 22g, Herba Artemisiae Annuae 17g, Flos Buddlejae 17g, Xi 17g, Folium Nandinae domesticae 17g, Radix Phytolaccae 17g, Flos Genkwa 12g, dish 12g, Radix Zanthoxyli Avicennae 12g, Radix Kansui 12g.