CN104666545A - External medicine bag for treating lower limb deep venous thrombosis - Google Patents
External medicine bag for treating lower limb deep venous thrombosis Download PDFInfo
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- CN104666545A CN104666545A CN201310635111.5A CN201310635111A CN104666545A CN 104666545 A CN104666545 A CN 104666545A CN 201310635111 A CN201310635111 A CN 201310635111A CN 104666545 A CN104666545 A CN 104666545A
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Abstract
The invention discloses an external medicine bag for treating lower limb deep venous thrombosis. The external medicine bag is prepared from a cotton surrounding applying medicine bag and the following traditional Chinese medicine components and raw materials in parts by weight: 800-1300 parts of mirabilite, 8-12 parts of borneol, 5-15 parts of coptis roots, 15-25 parts of barks of Chinese corktree, 15-25 parts of rhubarb and 0.01-0.02 part of dexamethasone. The raw materials with the proportions are repeatedly stirred uniformly, air-dried, ground, and then put into the cotton medicine bag, the medicine bag is applied to an affected limb by surrounding, and the medicine bag is replaced in time after being moistened to perform external application continuously. The external medicine bag with combination of Chinese and Western medicines, which is used for treating the lower limb deep venous thrombosis, is clinically proved to be quick in response, good in curative effect and convenient in use when being used for treating the lower limb deep venous thrombosis.
Description
Technical field
The present invention relates to a kind of externally used medicine bag for the treatment of deep vein thrombosis of lower extremity.
Background technology
The complication that deep venous thrombosis of lower limbs is operation, the patient that gives a birth is common, patient's vein pressure is high, and cause serious obstruction to veins of lower extremity backflow, oppress artery of lower extremity, the strong spasm of its limb artery, causes limbs blood supply insufficiency simultaneously.Venous thrombosis is in stage acute stage as diagnosis and management not in time, and some patient Ke Yin thrombus breaks loose cause pulmonary infarction.Fail timely processor majority and can not to escape by luck the generation of Chronic thromgbosis sequela, cause the long-term sick pain of patient to affect live and work ability, severe patient can be disabled.Deep vein thrombosis of lower extremity clinically with lower limb obviously slightly swollen, distending pain for feature, eliminate rapidly the emphasis that limb swelling is treatment.
The Topical therapy of current treatment deep vein thrombosis of lower extremity is more, has and encloses dressing treatment method, fumigation-washing therapy etc.And to enclose dressing treatment method be one of common external therapy.But it is undesirable to there is therapeutic effect in the medicine for enclosing dressing treatment method in prior art, the defect that the side effect such as skin allergy and skin eczema is large.Need the better medicine of a kind of therapeutic effect.By the Learning Studies analyzed Chinese medicine traditional theory and Chinese medicine and western medicine pharmaceutical component, invent a kind of Integrated TCM externally used medicine bag for the treatment of deep vein thrombosis of lower extremity, limb swelling can have been alleviated rapidly, improve promoting extremities blood circulation, strengthen curative effect, avoid the toxic and side effects such as drug allergy.
Summary of the invention
For above-mentioned technical background, the invention provides the externally used medicine bag that a kind of therapeutic effect is better used for the treatment of deep vein thrombosis of lower extremity.
A kind of externally used medicine bag for the treatment of deep vein thrombosis of lower extremity of the present invention, is made up of the Chinese medicinal components of following quality proportioning and raw material: Natrii Sulfas 800-1300, Borneolum Syntheticum 8-12, Rhizoma Coptidis 5-15, Cortex Phellodendri 15-25, Radix Et Rhizoma Rhei 15-25, dexamethasone 0.01-0.02.
Described a kind of externally used medicine bag for the treatment of deep vein thrombosis of lower extremity, is characterized in that the optimum weight proportioning composition of Chinese medicinal components and raw material is: Natrii Sulfas 1000, Borneolum Syntheticum 10, Rhizoma Coptidis 10, Cortex Phellodendri 20, Radix Et Rhizoma Rhei 20, dexamethasone 0.01.
Described a kind of externally used medicine bag for the treatment of deep vein thrombosis of lower extremity, is characterized in that: by the Chinese medicinal components of described proportioning and raw material stirring and evenly mixing, airing, grinding repeatedly, seals and make after loading cotton encloses Medicine applying bag.
Using method of the present invention.Being enclosed by medicated bag spreads in suffering limb, after medicated bag soaks, changes in time, continues external application, when until both limbs is fixed a point, all footpaths difference is less than 1cm, can stop using.
A kind of externally used medicine bag for the treatment of deep vein thrombosis of lower extremity of the present invention, pharmacology analysis is as follows: Natrii Sulfas has dehydration.Borneolum Syntheticum can improve cutaneous permeability and can absorptive tissue interstitial fluid rapidly, alleviates limbs tension force, promotes the opening of Doppler flow mapping, extremity vascular is expanded, improves blood circulation, reach the object of extremity repercussive.Rhizoma Coptidis and Cortex Phellodendri have the effect of clearing away heat-damp and promoting diuresis, removing toxic substances and detumescence, and Rhizoma Coptidis and Cortex Phellodendri contain berberine, have the inhibitory action of highly significant to being rich in hematoblastic clot retracts.After suppressing clot retracts, there is obvious facilitation to the clot dissolution that urokinase and streptokinase cause, therefore there is antiplatelet aggregation and thrombolytic effect.Radix Et Rhizoma Rhei has the effect of activating blood circulation to dissipate blood stasis, and it contains anthracene glycoside derivative also containing rhatannin and related substances, as gallic acid, cachou extract and tetrarin etc. can anti-lipid peroxidation thing malonaldehyde, can alleviate injuries of tissues and organs.Western medicine dexamethasone tablet has antiallergic, anti-inflammatory transudation.
The externally used medicine bag for the treatment of deep vein thrombosis of lower extremity of the present invention, has following effect:
1. rapid absorptive tissue interstitial fluid, alleviates limbs tension force, promotes the opening of Doppler flow mapping, extremity vascular is expanded, improves blood circulation.
2. blood vessel dilating, blood circulation promoting, improves microcirculation, obviously can improve the blood circulation of venous system of lower extremity, promotes blood backflow, reduces intravenous congestion, limb swelling is alleviated.Also expansible blood capillary, improves the oxygen concentration in microcirculation, reduces the generation of acidic metabolite.Clinical manifestation be the symptoms such as limb swelling, pain, color of the leather be abnormal be improved significantly, lower limb week footpath obviously reduce.
3. anticoagulant and fibrinolytic is strengthened, the APTT(Activated partial thromboplastic time of reaction intrinsic coagulation system can be made) obviously extend, AT-III (antithrombin-Ⅲ) mobility improves, and illustrates that it has anticoagulation on the whole, the hypercoagulability of blood samples of patients is eased.Promote after treatment that Fibrinolytic tPA (tissue plasminogen activator) significantly increases, suppress Fibrinolytic PAI(Plasminogen activator mortifier) decline to some extent, illustrate that it has certain facilitation to the activity of fibrinolytic system.PLg(plasminogen) reduction of mobility and FIB(Fibrinogen) minimizing then directly describe fibrinolytic activity and increase and Fibrinolytic acceleration.
4. reduce plasma viscosity, reduce platelet aggregation, inhibition thrombosis.Can dilute blood, the hypercoagulability of blood is eased, lowers blood viscosity, reduce hematoblastic gathering, adhesion and release, suppress the formation of thrombosis.
Detailed description of the invention
Embodiment 1
Get Chinese medicinal components and the raw material of following weight portion: by Natrii Sulfas 1000g, Borneolum Syntheticum 10g, Rhizoma Coptidis 10g, the quality proportioning of Cortex Phellodendri 20g, Radix Et Rhizoma Rhei 20g, dexamethasone 10mg, stirring and evenly mixing, airing, grinding repeatedly, loads after the cotton of 60 × 40cm encloses Medicine applying bag and tightly encapsulates.
Embodiment 2
Get Chinese medicinal components and the raw material of following weight portion: by Natrii Sulfas 1200g, Borneolum Syntheticum 12g, Rhizoma Coptidis 12g, the quality proportioning of Cortex Phellodendri 24g, Radix Et Rhizoma Rhei 24g, dexamethasone 20mg, stirring and evenly mixing, airing, grinding repeatedly, loads after the cotton of 70 × 50cm encloses Medicine applying bag and tightly encapsulates.
Embodiment 3
Use embodiment 1 and the medicated bag described in embodiment 2 to carry out clinical experiment, data are as follows:
Subjective symptoms change (x ± s) before and after deep venous thrombosis treated by table 1
Table 1 point system:
Edema: lower limb Zhou Jing is measured at 15cm place below the above 15cm of patella upper limb, patella lower edge, same plane Zhou Jing, than within the large 2cm in strong side, belongs to normal, remembers 0 point; Large 2 ~ 3(is not containing 3) cm is 1 point; Large 3 ~ 4(is not containing 4) cm is 2 points; Large 4 ~ 5(is not containing 5) cm is 3 points; Large 5 ~ 6(is not containing 6) cm is 4 points.The rest may be inferred calculates.
Distending pain: this symptom can be swollen or pain, is normally 0 point; Swollen or pain 1 point after movable; In time, have from swelling or pain 2 points; Persistence distending pain 3 points; Distending pain unbearably, dysphoria is 4 points.
Color of the leather is abnormal: be normally 0 point; Sometimes dark red or pale be 1 point; Persistence is dark red or pale is 2 points; Persistence is livid purple is 3 points.
SPSS17.0 software is used to carry out statistical procedures, before and after the treatment for the treatment of group indices, there were significant differences (P < 0.01), there were significant differences (P < 0.01) at distending pain item for matched group, edema item and color of the leather exception item variant (P < 0.05).
15cm lower limb week footpath change (x ± s) under kneecap to be treated before and after deep venous thrombosis by table 2
| Group | Before treatment | After treatment |
| Treatment group (n=65) | 37.65±3.13 | 33.24±2.15 |
| Matched group (n=61) | 37.02±3.22 | 35.45±2.73 |
SPSS17.0 software is used to carry out statistical procedures, treatment group has notable difference (P < 0.01) before and after the footpath treatment of 15cm lower limb week under kneecap, before and after all footpaths treatment of matched group 15cm lower limb under kneecap variant (P < 0.05).
As can be seen from table 1 and table 2, the various clinical index for the treatment of group is all significantly improved, and illustrates that externally used medicine bag deepens good therapeutical effect for limb swelling, pain, heating and the colour of skin; For improving Deep venou blood flow, eliminate limb swelling, reduce lower limb Zhou Jing and also have obvious effect; Though matched group Visual symptoms makes moderate progress, curative effect is obvious not as treatment group.
Blood clotting change (x ± s) before and after deep venous thrombosis treated by table 3
SPSS17.0 software is used to carry out statistical procedures, the AT-III activity angle value for the treatment of group has significant difference (P < 0.01) before the treatment afterwards, other indices before the treatment after all variant (P < 0.05); Matched group is at PLg mobility variant (P < 0.05), and other indices are rear all zero differences (P > 0.05) before the treatment.
From table 3, externally used medicine bag for clotting system impact clearly, significantly increase after can seeing the tPA treatment promoting fibrinolytic, the PAI of fibrinolytic is suppressed obviously to decline, the APTT of reaction intrinsic coagulation system extends to some extent, AT-III mobility raises, and FIB significantly reduces after the treatment, and PLg activity also weakens to some extent.Illustrate that this medicine has good therapeutical effect to the hypercoagulability alleviating Deep vein post-thrombosis syndrome blood samples of patients.And matched group clotting system change and not obvious, curative effect is more weak.
The change (x ± s, cm) that lower limb color ultrasound before and after deep venous thrombosis shows vein internal diameter treated by table 4
Use SPSS17.0 software to carry out statistical procedures, the indices for the treatment of group before the treatment after all have significant difference (P < 0.01), the indices of matched group before the treatment after equal zero differences (P > 0.05).
As seen from Table 4, after application externally used medicine bag, the internal diameter of patient's veins of lower extremity has reducing in various degree, and after medication is described, the backflow of patient's deep veins of lower limb is improved, and intravenous congestion is eased.In the deep veins of lower limb of matched group congestion not be improved significantly.
Deep venous thrombosis curative effect treated by table 5
Table 5 point system: evaluate curative effect with the mark ratio size before treating rear and treatment, sum of namely scoring after treatment in table 1 is compared with sum of scoring before treating: clinical recovery: be less than 0.3; Effective: 0.3 ~ 0.6(is not containing 0.6); Effective: 0.6 ~ 0.9(is not containing 0.9); Invalid: 0.9 ~ 1(is containing 1); Worsen: be greater than 1.
From table 5, externally used medicine bag reaches 97% for treatment deep venous thrombosis total effective rate, apparently higher than matched group, and has higher clinical cure rate, determined curative effect.Obviously can alleviate the symptom such as limb swelling, pain of deep venous thrombosis of lower, improve the blood circulation of veins of lower extremity, also have certain therapeutical effect to the hypercoagulability of blood samples of patients; Comparatively matched group has more obvious curative effect.
By the observation to 128 routine deep venous thrombosis of lower clinical practices, find matched group, the extremity repercussive time at about 14 days, and uses the externally used medicine bag extremity repercussive time at about 4 days, occurs without eczema and allergic phenomena.
Claims (3)
1. treat an externally used medicine bag for deep vein thrombosis of lower extremity, be made up of the Chinese medicinal components of following quality proportioning and raw material: Natrii Sulfas 800-1300, Borneolum Syntheticum 8-12, Rhizoma Coptidis 5-15, Cortex Phellodendri 15-25, Radix Et Rhizoma Rhei 15-25, dexamethasone 0.01-0.0.02.
2. a kind of externally used medicine bag for the treatment of deep vein thrombosis of lower extremity according to claim 1, is characterized in that the weight proportion composition of Chinese medicinal components and raw material is: Natrii Sulfas 1000, Borneolum Syntheticum 10, Rhizoma Coptidis 10, Cortex Phellodendri 20, Radix Et Rhizoma Rhei 20, dexamethasone 0.01.
3. a kind of externally used medicine bag for the treatment of deep vein thrombosis of lower extremity according to claim 1 and 2, is characterized in that: by the Chinese medicinal components of described proportioning and raw material stirring and evenly mixing, airing, grinding repeatedly, seals and make after loading cotton encloses Medicine applying bag.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310635111.5A CN104666545A (en) | 2013-12-03 | 2013-12-03 | External medicine bag for treating lower limb deep venous thrombosis |
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| CN201310635111.5A CN104666545A (en) | 2013-12-03 | 2013-12-03 | External medicine bag for treating lower limb deep venous thrombosis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109718A (en) * | 2016-08-16 | 2016-11-16 | 赵卫东 | A kind of External-applicationtraditional traditional Chinese medicinal treating lower limb lymphedema |
| CN107551030A (en) * | 2017-09-20 | 2018-01-09 | 邓红玉 | A kind of Chinese medicinal formulae, preparation and the preparation method of anti-venous thronbosis |
Citations (2)
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| CN1269214A (en) * | 1997-08-19 | 2000-10-11 | 黄付堂 | Thrombus dissolving capsule |
| CN101095728A (en) * | 2007-07-12 | 2008-01-02 | 陈军良 | Medicament for treating thromboangitis obliterans and method for producing the same |
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2013
- 2013-12-03 CN CN201310635111.5A patent/CN104666545A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1269214A (en) * | 1997-08-19 | 2000-10-11 | 黄付堂 | Thrombus dissolving capsule |
| CN101095728A (en) * | 2007-07-12 | 2008-01-02 | 陈军良 | Medicament for treating thromboangitis obliterans and method for producing the same |
Non-Patent Citations (3)
| Title |
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| 刘惠洁: "冰硝散外敷治疗下肢深静脉血栓形成患肢水肿的疗效观察", 《中国现代医生》 * |
| 李静等: "京万红与地塞米松联合外用治疗化疗性静脉炎的观察", 《天津护理》 * |
| 陈建华: "中医护理技术之敷药法的临床应用近况", 《四川中医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109718A (en) * | 2016-08-16 | 2016-11-16 | 赵卫东 | A kind of External-applicationtraditional traditional Chinese medicinal treating lower limb lymphedema |
| CN107551030A (en) * | 2017-09-20 | 2018-01-09 | 邓红玉 | A kind of Chinese medicinal formulae, preparation and the preparation method of anti-venous thronbosis |
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