CN105816831B - A kind of external application application therapy tremble with fear stasis of blood ostalgia Chinese medicine composition and preparation method and application - Google Patents
A kind of external application application therapy tremble with fear stasis of blood ostalgia Chinese medicine composition and preparation method and application Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of Chinese medicine compositions of the cold stasis of blood ostalgia of external application application therapy, it is mainly made of the component of following parts by weight: 10~20 parts of ramulus cinnamomi, 10~20 parts of rhizoma zingiberis, 5~10 parts of flos caryophylli, 10~20 parts of lopseed, 10~20 parts of radix aconiti lateralis preparata, 15~30 parts of olibanum, 15~30 parts of myrrh, 20~40 parts of safflower, 10~20 parts of the root of Chinese clematis, 10~20 parts of Caulis Spatholobi, 20~40 parts of the bletilla striata, 50~100 parts of ginger.The invention also discloses the preparation method of above-mentioned Chinese medicine composition and applications.The Chinese medicine composition of the cold stasis of blood ostalgia of external application application therapy of the invention, treating both manifestation and root cause of disease play warm sun cold extermination, activating microcirculation and removing stasis medicinal altogether, the effect of dispelling wind and eliminating dampness, swelling and pain relieving, external use for curing periarthritis of shoulder, cervical spondylosis, Senile osteoarthritis, osteoporosis, cold pain in waist and lower extremities etc., Small side effects, it is curative for effect.
Description
Technical field
The present invention relates to a kind of Chinese materia medica preparations, and in particular to a kind of external application application therapy tremble with fear stasis of blood ostalgia Chinese medicine composition and
Preparation method and application.
Background technique
Scapulohumeral periarthritis, cervical spondylosis, degenerative osteoarthropathy, cold pain in waist and lower extremities, arthritis, osteoporosis etc., multilist show muscle,
Bone, the cold pain in joint is tingle or has swelling, meet it is cold then weighs, obtain hot, subtract, or be more common in gerontal patient with soreness and weakness of waist and knees etc.,
Chinese medicine thinks to enter old age, the deficiency of yang cannot warm fortune blood, kidney deficiency marrow do not fill and osteoporosis, and healthy energy is insufficient in addition, exogenous disease wind
Cold-dampness is evil, and numbness hinders channels and collaterals, and heresy violates passages through which vital energy circulates, joint, hinders QI-blood circulation, not general rule pain.Such disease is old common disease, multiple
Disease, its quality of life of pain, the unfavorable strong influence of activity, asks doctor numerous.Western medicine analgesic works rapidly, but there are more
Toxic side effect, especially to old and hepatic and kidney function obstacle patient.Point application therapy is in motherland's medicine theory of channels and collaterals
Guidance under, on the basis of diagnosis and treatment, by medicament plaster body surface privileged site, to treat a kind of method of disease.
With the increase of endo-medicine therapy toxicity and drug resistance, point application therapy is increasingly subject to the attention of medical field colleague.
There is the percutaneous absorbtion of drug and pair of meridian point effect according to the meridian point application therapy that Chinese medicine meridian theory proposes
Characteristic is treated again, medicine irritation part meridian point can excite whole body through gas, generate the relative advantage of drug concentration in part,
And conveyed by the absorption of tiny blood vessels, play maximum systemic pharmacologic effect.It is small with toxic reaction, treating both manifestation and root cause of disease excellent
Gesture can improve symptom in acute stage and be improved in chronic phase and paracmasis, to reduce recurrence.But it is curative for effect,
Mature Chinese medicine with strong points is rarely seen.
Currently, western medical treatment is mainly the following mode: (1) antalgesic: Paracetamol can cause fash, granulocyte
And decrease of platelet, long term usage can cause hepatorenal damage；Opium kind analgesics may occur in which according to resistance to additive, need to strictly grasp indication；
(2) non-steroid anti-inflammatory drug: diclofenac can cause to have a stomach upset, fash, dizziness, headache etc., occur acute renal individually
Failure or explosive hepatitis；Selective COX-2 inhibitor such as rofecoxib and celecoxib have research to prompt, and long-term use can be led
Cardia cevent is caused to increase.(3) Limethason or hydrocortisone acetate Caledonia cacaine intraarticular injection, repeatedly
It is precipitated using intra-articular crystalloid is also easy to produce, has detrimental effect to cartilage.Chinese medicine and externally applied ointment at present, from Chinese traditional treatment mechanism
On see, only for wherein a certain link or wind-dispelling or stagnation resolvation or kidney tonifying or fragrance relieve pain, it is difficult to take into account temperature male wind-supplying kidney, ward off the cold
The effect of blood stasis dispersing and deswelling relieves pain.Specific aim is not strong, and uncertain therapeutic efficacy is cut.
Summary of the invention
The technical problem to be solved by the present invention is to be directed to the deficiencies in the prior art, a kind of external application application is provided and is controlled
Treat the Chinese medicine composition of cold stasis of blood ostalgia, with alleviate muscle, bone, the cold pain in joint are tingle, meet it is cold then weigh or have swelling, activity is not
The clinical symptoms of benefit.
The present invention also technical problems to be solved are to provide the preparation method of above-mentioned Chinese medicine composition.
The last technical problems to be solved of the present invention are to provide the application of above-mentioned Chinese medicine composition.
In order to solve the above technical problems, The technical solution adopted by the invention is as follows:
A kind of Chinese medicine composition of the cold stasis of blood ostalgia of external application application therapy, it is mainly made of the component of following parts by weight:
10~20 parts of ramulus cinnamomi, 10~20 parts of rhizoma zingiberis, 5~10 parts of flos caryophylli, 10~20 parts of lopseed, 10~20 parts of radix aconiti lateralis preparata, olibanum 15
~30 parts, 15~30 parts of myrrh, 20~40 parts of safflower, 10~20 parts of the root of Chinese clematis, 10~20 parts of Caulis Spatholobi, 20~40 parts of the bletilla striata,
50~100 parts of ginger.
The Chinese medicine composition of the cold stasis of blood ostalgia of above-mentioned external application application therapy is preferably mainly made of the component of following parts by weight:
10 parts of ramulus cinnamomi, 10 parts of rhizoma zingiberis, 5 parts of flos caryophylli, 10 parts of lopseed, 10 parts of radix aconiti lateralis preparata, 15 parts of olibanum, 15 parts of myrrh, 20 parts of safflower,
10 parts of the root of Chinese clematis, 10 parts of Caulis Spatholobi, 20 parts of the bletilla striata, 50 parts of ginger.
The preparation method of the Chinese medicine composition of the cold stasis of blood ostalgia of above-mentioned external application application therapy, it includes the following steps:
(1) by the radix aconiti lateralis preparata of formula ratio, ramulus cinnamomi, rhizoma zingiberis, flos caryophylli, olibanum, myrrh, lopseed, the root of Chinese clematis, safflower, chicken
Blood rattan and bletilla striata mixing, being ground into fine powder, to cross 80 meshes spare；
(2) ginger of formula ratio is minced plus the water of ten times of weight decocts twice, 30~60 minutes every time, filtered, merge
Filtrate is concentrated to give gingerade；
(3) fine powder for obtaining step (1) is set and is gradually added the gingerade that step (2) obtains in U-shaped mixing channel, then plus
Enter glycerol and maltose is stirred, paste is made until stirring evenly；
(4) by paste made of step (3) be uniformly applied on application film to get.
In step (2), it is concentrated into the gingerade of 2~4 times of ginger weight.
In step (3), the weight ratio of gingerade, glycerol and maltose is 15~30:1~2:5~10.
The Chinese medicine composition of the cold stasis of blood ostalgia of above-mentioned external application application therapy also exists in the application prepared in cure scapulohumeral periarthritis drug
Within protection scope of the present invention.
Application of the Chinese medicine composition of the cold stasis of blood ostalgia of above-mentioned external application application therapy in preparation treatment cervical vertebra medicine also exists
Within protection scope of the present invention.
The Chinese medicine composition of the cold stasis of blood ostalgia of above-mentioned external application application therapy is in preparation treatment Senile osteoarthritis drug
Using also within protection scope of the present invention.
Application of the Chinese medicine composition of the cold stasis of blood ostalgia of external application application therapy in preparation treatment medicine for treating osteoporosis is also at this
Within the protection scope of invention.
Above-mentioned Chinese medicine composition external use for curing periarthritis of shoulder, cervical spondylosis, Senile osteoarthritis, osteoporosis, cold waist-leg
Pain etc..There is the percutaneous absorbtion and meridian point effect of drug according to the meridian point application therapy that Chinese medicine meridian theory proposes
Double treatment characteristic, medicine irritation part meridian point can excite whole body through gas, locally generate the relatively excellent of drug concentration
Gesture, and conveyed by the absorption of tiny blood vessels, play maximum systemic pharmacologic effect.
The Chinese medicine compound prescription of the cold stasis of blood ostalgia of external application application therapy of the invention is brown paste after preparing, each 3-5 grams of smearing
In on dedicated acupuncture point application film, for following through institute's acupoint selection position and pain point.Function: the cold extermination of temperature sun, activating microcirculation and removing stasis medicinal, wind-dispelling remove
It is wet, swelling and pain relieving.For scapulohumeral periarthritis, cervical spondylosis, degenerative osteoarthropathy, cold pain in waist and lower extremities, arthritis, osteoporosis etc..
External application application therapy of the invention is trembled with fear the Chinese medicine compound prescription of stasis of blood ostalgia: in formula in side with radix aconiti lateralis preparata, rhizoma zingiberis, osmanthus
Branch, flos caryophylli mends fire supporing yang cold dispelling, warming meridians and promoting circulation of qi analgesic consolidate cold solidifying to control its deficiency of yang；Olibanum, myrrh, safflower, Caulis Spatholobi are living
Blood and relieving pain, detumescence and promoting granulation, blood-nourishing stagnation resolvation, warming and activating meridian temporary solution dissolving stasis are to control its hematogenous blockage；Lopseed, root of Chinese clematis temporary solution wind-dispelling
Dehumidifying, tonneau channels and collaterals are to control rheumatic arthralgia；Ginger juice temperature leads to cold dispelling, bletilla striata skin care reconciles and adheres to all medicines.Treating both manifestation and root cause of disease plays Wen Yang altogether
The effect of cold extermination, activating microcirculation and removing stasis medicinal, dispelling wind and eliminating dampness, swelling and pain relieving.Wherein:
Radix aconiti lateralis preparata: having significant anti-inflammatory effect, can inhibit rat toes swelling caused by egg white, carrageenan, formaldehyde etc., suppression
Capillary permeability caused by acetic acid processed is hyperfunction, inhibits granuloma formation and adjuvant-induced arthritis.Monkshood anti-inflammatory effect it is main
Effective component is considered as aconitine compounds containing, and the 50 3nhibitory dose for croton oil induced mice ear swelling aconitine is
0.07mg/kg, much better than compared with Indomethacin, 0.05mg/kg intraperitoneal injection is to the foot of rat caused by egg white, carrageenan, formaldehyde etc.
Toe swelling has significant antiphlogistic effects.It is carried out with anti-inflammatory activity of the kinds of experiments model to gun additioner hot water extract (A-ext)
Research.From 5d after the day of injection adjuvant or injection adjuvant, A-ext is continuously taken, to rat level-one joint as caused by adjuvant
Scorching and second level arthritis has apparent inhibiting effect.The experimental results showed that A-ext can inhibit the arthritis of adjuvant induction and have
The effect of allied organization's amine.Monkshood decoction is in obvious antiinflammation to the formaldehyde and swollen joint of rat, has and inhibits blood capillary
Pipe infiltration, inhibits granuloma to be formed, anti-inflammatory and antalgic detumescence effect.
Ramulus cinnamomi: the intraperitoneal injection of ramulus cinnamomi injection, one time a day, each 10ml (containing crude drug 20g), continuous 5d can be to anti-rabbit reality
The skin of the property tested limb paralysis model, muscle, nerve and hemorheology pathological change.Improve tissue blood circulation, eliminates
The oedema of sarcoplasmic reticulum and schwann cell endoplasmic reticulum reverses pathological tissues and repairs.Research finds that cinnaldehydrum in vitro can be obvious
The aggregation for inhibiting blood platelet in the rat plasma of collagen and thrombin induction, after capable of significantly extending mouse docking in vivo
Go out ' clotting time, mitigate rat move 7 venous bypass silk threads on thrombus quality, illustrate cinnaldehydrum have obvious antiplatelet
Aggregation and internal anti thrombotic action its mechanism may be with the formation that inhibit thromboxane element, and then inhibition platelet aggregation is related.
Rhizoma zingiberis, ginger: water, the ether extract of rhizoma zingiberis have apparent anti-inflammatory effect, can inhibit ear caused by dimethylbenzene
Rat paw edema caused by swelling and carrageenan, the dilute ketone of ginger can obviously inhibit histamine and acetic acid induced mice capillary
Permeability increases, and inhibits granulation hyperplasia.And have analgesic activity, it can be reduced acetic acid and cause mouse writhing reaction times, and closed in dose-effect
System.Rhizoma zingiberis water extract has apparent inhibiting effect to the platelet aggregation of ADP, collagen enzyme induction, postpones experimental vein thrombosis,
Ginger ketenes also have inhibiting effect to the generation of Rabbit Blood Platelets peroxidase activity and TXA2.Rhizoma Zingiberis volatile oil also has antithrombotic
The effect of formation, and white bole thromboplastin time can be obviously prolonged.Ginger ethanol extract intraperitoneal administration, can inhibit Irish moss
Rat paw edema and hydroderma caused by glue and serotonin (52HT).
Flos caryophylli: cloves ether extract and water extract stomach-filling reduce the mouse peritoneal capillary permeability that acetic acid improves, suppression
Dimethylbenzene mouse ear swelling processed and Irish moss colloidality rat paw edema inhibit acetic acid to cause mouse writhing reaction, extend mouse
Hot plate reaction incubation period [28].β-cloves alkene is in half diaphragm experiment in vitro of rabbit conjunctival reflex experiment in vivo and rat diaphragm
There is topical pain relief effect to have studied volatile clove oil, Eugenol, warp of the cloves alcohol extract to 5-fluor-uracil (5-Fu)
The transdermally effect of crossing, discovery can be such that the transit dose of 5-Fu increases, the above two effect is slightly strong compared with azone.As a result it prompts, Chinese medicine fourth
Perfume (or spice) is expected to be applied in the Percutaneously administrable preparation of some drugs as transdermal enhancer.
Olibanum: analgesic activity: prove that Olibanum volatile oil has analgesic activity, anti-inflammatory antisepsis: olibanum with hot plate method in mice
Polynuclear leucocyte can be promoted to increase, to swallow dead blood cell and cell, improve metabolism, to play antiinflammation.At random
Double-blind study investigates the curative effect for the rats with arthritis that Olibanum extract induces adjuvant, and Olibanum extract has significant as the result is shown
Anti-inflammatory effect, mechanism may be related with the generation of proinflammatory cytokines is inhibited.It is preclinical to Olibanum extract
The study found that its pain that can mitigate gonitis patient, enhances bending and stretching to reduce the knuckle of joint part simultaneously for Bones and joints
There is repair function.It prompts the extract to cannot be only used for treatment gonitis, other kinds of arthritis can also be treated.
Myrrh: various processed products have significant or highly significant detumescence to make after being applied with to mouse foot swelling caused by wound
With, if with health product myrrh be applied with its blood stasis dispersing and deswelling effect it is then stronger, this may be after processing drug effect because volatilization oil mass reduce
Related, the strong analgesic activity of Myrrha extract may act on opiate receptor in brain as morphine, but without morphine addiction
Side effect.With honey and do not have medicinal powder that paint is made to be externally applied to diabetic foot ulcer infected patient affected part, the next day dressing 1 time, 2 weeks
Discovery inflammation is controlled afterwards, and ulcer surface starts gradually to heal.
Lopseed: the mouse abdominal pain that lopseed Dichlorodiphenyl Acetate induces has apparent analgesic activity, in anti-inflammatory aspect, lopseed
Mouse peritoneal capillary permeability can be reduced significantly, reduce the exudation of dyestuff.Lopseed plant chemical ingredient mainly wraps
The multiple compounds such as alkaloid, organic acid etc., sterol, pyrimidine are included, there is treatment rheumatic arthritis, anti-inflammatory and analgesic effect, control
Treat the Clinical pharmacological efficiencies such as keloid, treatment talagia.Lopseed contains ferulic acid, can inhibit anxious caused by a variety of proinflammatory agents
Capillary permeability increases property, inflammatory exudate increases and tissue edema and inflammation later period granulation tissue hyperplasia etc..
The root of Chinese clematis: analgesic and anti-inflammatory effects root of Chinese clematis injection and its large dosage of decoction have mouse writhing caused by glacial acetic acid
There is inhibiting effect, shows significant analgesic activity.It is demonstrated experimentally that root of Chinese clematis decoction can be bright to pain reaction caused by thermostimulation
The aobvious pain threshold for improving mouse, and it is relatively strong and lasting to the analgesic activity of wine toast product.Its injection can significantly inhibit diformazan
Mice auricle swelling caused by benzene can significantly inhibit the growth of rat granulation tissue caused by the scraps of paper, have and inhibit capillary penetrating
Property effect, large dosage, which gavages, causes scorching model to have certain protective effect in rat paw portion caused by 10% egg white.Root of Chinese clematis preparation
Osteoarthritis can be prevented and treated.It is as follows that it prevents and treats mechanism: the root of Chinese clematis can promote and maintain cartilage cell's synthesis ò Collagen Type VI and albumen more
Sugar helps its anabolism；Inhibit the cell factors such as interleukin-1 B, effectively prevents interleukin-1 B and its downstream molecules to cartilage
Damage effect.
Safflower: there is obvious inhibiting effect to rat formaldehyde foot swelling, and significantly inhibit rat skin hair caused by histamine
Thin vasopermeability increases, and also has obvious inhibiting effect to the formation of rat cotton balls granuloma.Safflower ethyl alcohol is to Prophylactic chemotherapy
Phlebitis has remarkable result, and applying hot soaks artery, vein internal fistula can significantly reduce blood vessel cicatrization and prevention blood vessel stenosis.
The blood stasis model rat whole blood viscosity reduction after Sofflower injection is given in research, and platelet aggregation is suppressed " RBC deformation
Ability is improved.Safflower has certain anti-inflammatory and antalgic activity, and the carthamin yellow and Sydroxy carthamin in safflower are
The main active of its anti-inflammatory and antalgic.Hot-plate analgesic test the result shows that, the large, medium and small dosage of safflower can be different degrees of
Percentage is improved in the threshold of pain and the threshold of pain for improving mouse.The influence of mouse auricular concha swelling is the results show that red caused by paraxylene
Spending the auricular concha swelling of large dosage of paraxylene induced mice has improvement result.Greatly, middle dosage Carrageenan subcutaneous injection is led
The pedal swelling of cause all has certain inhibiting effect, for caused by skin trauma infected with preventing postoperative adhesions, hemostasis, inflammation
Property exudation and promote wound healing, the regenerated effect of induced skin.Safflower can reduce Rats with inflammation vola inflammatory reaction substance
PGE2 is horizontal, has certain anti-inflammatory, analgesic activity, can promoting blood circulation and stopping pain, prevent from infecting, help and promote being cured as early as possible for wound
It closes.
Caulis Spatholobi: the hot water extract of Caulis Spatholobi has strong inhibition on platelet aggregation.Wet weight of thrombus can be reduced, is had
Anti-thrombosis function.Caulis Spatholobi ethanol extract (removing polyphenol compound) with anti-inflammatory effect to having in addition to COX-2
The enzyme of pass all has inhibiting effect, shows that Caulis Spatholobi has certain anti-inflammatory effect.Caulis Spatholobi is to rat ferment nurse foot epidemic disease toe swelling
Influence: rat 18, give two groups of medicine and control, be administered twice by 6g/kg, interval is 12 small right, is measured and is caused with lifting rate method
Sufficient volume that is scorching preceding and causing different time after inflammation.As a result, Caulis Spatholobi different time after proinflammatory agent shows stronger inhibition
Effect.
The bletilla striata: animal experiment is studies have shown that bletilla can be such that rat back incised injury surface of a wound the average healing shifts to an earlier date, together
When can improve hydroxyproline content and protein content in wound tissue, and improve wound macrophage quantity, this may be it
One of the important mechanisms of promoting healing effect.This effect that bletilla has is mainly related with its contained gelling ingredient.By bletilla glue
As Recombinant human epidermal growth factor carrier, the synthesis of surface of a wound superficial cell DNA can be remarkably promoted, improves the increasing of cell
Ability is grown, wound healing time, accelerating wound healing are shortened.
The advantage of the invention is:
Radix aconiti lateralis preparata, ramulus cinnamomi, rhizoma zingiberis, flos caryophylli, ginger juice --- the cold extermination of temperature sun, coronary circulation-promoting pain-relieving；
Olibanum, myrrh --- promoting blood circulation and stopping pain, detumescence and promoting granulation；
Lopseed, the root of Chinese clematis --- dispelling wind and eliminating dampness, promoting menstruation are deep；
Safflower, Caulis Spatholobi --- blood-nourishing stagnation resolvation, warming and activating meridian；
The bletilla striata --- cuticula detumescence adheres to all medicines.
The effect of all medicines close it, there is temperature sun to ward off the cold, activating microcirculation and removing stasis medicinal, dispelling wind and eliminating dampness, swelling and pain relieving, clinical practice proves it
It is arthralgic curative for effect to treat cold stasis of blood type.Effect: clinical observation is controlled after treatment in terms of pain, function of joint, comprehensive score
Treatment group compared with the control group, (scalar quantizations such as pain relief, function of joint activity, synthesis integral), pretherapy and post-treatment symptom integral
Front and back has the difference of significant difference P < 0.01 statistically significant, and treatment group is substantially better than control group, has no apparent side effect.Through
Network point application therapy has the percutaneous absorbtion of drug and the double treatment characteristic of meridian point effect, and medicine irritation locally passes through
Luo-connecting point position can excite whole body through gas, convey in the relative advantage for locally generating drug concentration, and by the absorption of tiny blood vessels,
Play maximum systemic pharmacologic effect.Doctor and patient have been obtained in terms of the pain in waist and lower extremities of person in middle and old age joint by many years clinical use
Consistent favorable comment, dosage is unprecedented soaring year by year, for our hospital's Department of Aged treat person in middle and old age's arthralgia play an important role, have it is good
Good society and economic benefit.
Specific embodiment
According to following embodiments, the present invention may be better understood.However, as it will be easily appreciated by one skilled in the art that real
It applies content described in example and is merely to illustrate the present invention, without sheet described in detail in claims should will not be limited
Invention.
Embodiment 1:
A kind of Chinese medicine composition of the cold stasis of blood ostalgia of external application application therapy, it is mainly made of the component of following parts by weight:
10 parts of ramulus cinnamomi, 10 parts of rhizoma zingiberis, 5 parts of flos caryophylli, 10 parts of lopseed, 10 parts of radix aconiti lateralis preparata, 15 parts of olibanum, 15 parts of myrrh,
20 parts of safflower, 10 parts of the root of Chinese clematis, 10 parts of Caulis Spatholobi, 20 parts of the bletilla striata, 50 parts of ginger.
Specific preparation process:
(1) by the radix aconiti lateralis preparata of formula ratio, ramulus cinnamomi, rhizoma zingiberis, flos caryophylli, olibanum, myrrh, lopseed, the root of Chinese clematis, safflower, chicken
Blood rattan and bletilla striata mixing, being ground into fine powder, to cross 80 meshes spare；
(2) ginger of formula ratio is minced plus the water of ten times of weight decocts twice, 30 minutes every time, filtration, merging filtrate,
It is concentrated into the gingerade of 3 times of ginger weight；
(3) fine powder for obtaining step (1) is set and is gradually added the gingerade that step (2) obtains in U-shaped mixing channel, then plus
Enter glycerol and maltose is stirred, the weight ratio of gingerade, glycerol and maltose is 25:1:8, and paste is made until stirring evenly；
(4) by paste made of step (3) be uniformly applied on application film to get.
Embodiment 2:
A kind of Chinese medicine composition of the cold stasis of blood ostalgia of external application application therapy, it is mainly made of the component of following parts by weight:
20 parts of ramulus cinnamomi, 20 parts of rhizoma zingiberis, 8 parts of flos caryophylli, 20 parts of lopseed, 20 parts of radix aconiti lateralis preparata, 30 parts of olibanum, 25 parts of myrrh,
40 parts of safflower, 20 parts of the root of Chinese clematis, 20 parts of Caulis Spatholobi, 40 parts of the bletilla striata, 100 parts of ginger.
Specific preparation process:
(1) by the radix aconiti lateralis preparata of formula ratio, ramulus cinnamomi, rhizoma zingiberis, flos caryophylli, olibanum, myrrh, lopseed, the root of Chinese clematis, safflower, chicken
Blood rattan and bletilla striata mixing, being ground into fine powder, to cross 80 meshes spare；
(2) ginger of formula ratio is minced plus the water of ten times of weight decocts twice, 60 minutes every time, filtration, merging filtrate,
It is concentrated into the gingerade of 2 times of ginger weight；
(3) fine powder for obtaining step (1) is set and is gradually added the gingerade that step (2) obtains in U-shaped mixing channel, then plus
Enter glycerol and maltose is stirred, the weight ratio of gingerade, glycerol and maltose is 15:2:10, and paste is made until stirring evenly；
(4) by paste made of step (3) be uniformly applied on application film to get.
Embodiment 3:
1 clinical data
1.1 general information
All cases of being included in are to close in gerontology section, Jiangsu TCM Hospital outpatient service bone in December, -2015 in January, 2015
Scorching patient is saved, is divided into 2 groups: treatment group 180, wherein male 100, female 80；Age 56-92 years old, average age (77.57 ±
5.475) year；Course of disease average out to 6.92；Control group 175, wherein male 98, female 77；Age 57-92 years old, average age
(77.24 ± 5.328) year；The course of disease 6.56.2 groups of patients are in gender, age, the course of disease, disease feelings integral contrast no statistical difference
Meaning (P > 0.05), is comparable.
1.2 diagnostic criteria
1.2.1 referring to new Chinese medicine guideline of clinical investigations, " new Chinese medicine treats osteoarthritis to Western medicine diagnostic criteria
Guideline of clinical investigations " in diagnostic criteria.
1.2.2 tcm diagnosis standard: referring to State Administration of Traditional Chinese Medicine promulgate within 1994 " Chinese medical disease diagnoses curative effect mark
Quasi- ﹒ heumatism " diagnostic criteria.Cold-dampness presss from both sides stasis syndrome time standard: long-term arthralgia, activity are unfavorable, and sore spot is fixed, aversion to cold and cold limbs,
Fatigue aggravates, the dark whitish tongue of tongue, deep thready pulse etc..
1.3 are included in standard:
1. meeting Western medicine diagnostic criteria；2. meeting Chinese medicine cold-dampness folder stasis syndrome type；3. the age is greater than 55 years old.
1.4 exclusion criterias:
1. excluding rheumatism, rheumatoid arthritis, gout, joint tuberculosis, pyogenic arthritis, Kaschin-Beck disease；2. affected part skin
Skin is damaged or to Chinese medicine allergic constitution person；3. compliance difference cannot complete tester.
2 methods
2.1 treatment group
It follows to be bitterly acupoint and using lesion as the method for acupoint, it is periarticular swelling, hard to periarticular pain sensitivity point
Knot, tenderness position are as treatment site.Using my self-control side, section cold extermination stagnation resolvation bone pain medicine plaster (embodiment 1 is prepared) in perilesional
It takes 2-4 point to be applied with every time, controls with warm sun cold extermination, activating microcirculation and removing stasis medicinal, dispelling wind and eliminating dampness, swelling and pain relieving.Externally applied Chinese medicine production；In above
Medicine ground 80 meshes, and gingerade and glycerol, maltose are tuned into ointment, manufactured paste are uniformly applied to diameter and is applied for 6cm
On pad pasting, affected area is spread on.The daily time is 8-12 hours, the 7d1 course for the treatment of.
2.2 control group
Using analgesic rheumatoid plaster (Zhejiang Province DingTai Pharmaceutical Co., Ltd), external application one time a day, the 7d1 course for the treatment of, after 1 course for the treatment of
Carry out curative effect evaluation.
2.3 statistical method
For statistical analysis with SPSS17.0 software, data are indicated with mean ± standard deviation, different according to data property, point
It Cai Yong not t inspection, Chi-square Test and non-parametric test.Test statistics and its corresponding P value are provided, using P < 0.05 as having
Statistical significance, using P < 0.01 as there is height statistical significance.
2.4 curative effect determinate standard
1. pain visual imitation assessment method (VAS) evaluates pain degree, made before treatment, after treatment using same method
Scoring.
2. comprehensive therapeutic effect standard is asked using WOM-AC (scoring of Ontario and McMaster university Osteoarthritis Index) investigation
Volume, the calculation Nimodipine method common using clinic: ((pre-treatment score-post treatment integral)/pre-treatment score) ×
100%.(1) fully recover: pretherapy and post-treatment WOMAC integral reduces ﹤ 95%；(2) effective: 70%≤before and after treatment WOMAC integral reduce ﹤
95%；Effectively: 30%≤before and after treatment WOMAC integral reduce ﹤ 70%；(4) invalid: pretherapy and post-treatment WOMAC integral reduces insufficient
﹤ 30%.
3 results
3.1 treatment groups are compared with the VAS of control group scoring.
VAS scoring before two groups of patient's treatments is compared, and no significant difference (P > 0.05) is comparable.2 groups of trouble
VAS scoring is compared after person's treatment, and difference is statistically significant (P ﹤ 0.01), after 2 groups of patient's treatments compared with treating preceding VAS scoring
There is decline, difference is statistically significant (P ﹤ 0.01).Treatment group's compared with the control group is prompted, there is reduction arthralgia
Effect, and treatment group's curative effect is substantially better than control group, is shown in Table 1.
The pretherapy and post-treatment VAS scoring of 1 two groups of cases of table is compared
3.2 treatment groups are compared with the scoring of the WOMAC of control group
WOMAC scoring before two groups of patient's treatments is compared, and no significant difference (P > 0.05) is comparable.Two
WOMAC scoring has decline compared with before treatment after group patient's treatment, and difference is statistically significant (P ﹤ 0.01), but in joint deadlock
Hard aspect, treatment group and control group scoring are compared after treatment, no significant difference (P > 0.05)；Pain, function of joint,
In terms of comprehensive score, compared with the control group, difference is statistically significant (P ﹤ 0.01) for treatment group after treatment.Illustrate two groups for the treatment of knees
Osteoarthritis is effective, and two groups compared in terms of for improving arthralgia, function of joint and comprehensive score, treatment group better than pair
According to group, but the no significant difference in terms of improving anchylosis.It is shown in Table 2.
The pretherapy and post-treatment WOMAC scoring of 2 two groups of cases of table is compared
It discusses:
Into old age, Osteoarthritis lesion is multiple, and Chinese medicine is under the jurisdiction of " heumatism " scope, and pathomechanism thinks that the deficiency of yang cannot
Warm fortune blood, kidney deficiency marrow do not fill and osteoporosis, and healthy energy is insufficient in addition, affection of exogenous wind-cold damp evil, numbness resistance channels and collaterals, heresy criminal passages through which vital energy circulates,
Joint hinders QI-blood circulation, not general rule pain.Cold extermination stagnation resolvation bone pain medicine plaster is derived from the experience external application in Jiangsu TCM Hospital's old age through luo-connecting point
The position side of sticking, by safflower, the bletilla striata, olibanum, myrrh, ramulus cinnamomi, rhizoma zingiberis, lopseed, radix aconiti lateralis preparata, the root of Chinese clematis, Caulis Spatholobi, flos caryophylli etc.
Chinese medicinal composition.With, with radix aconiti lateralis preparata, rhizoma zingiberis, ramulus cinnamomi, flos caryophylli mends fire supporing yang cold dispelling, warming meridians and promoting circulation of qi analgesic is consolidated to control in side in side
Its deficiency of yang is cold solidifying；Olibanum, myrrh, safflower, Caulis Spatholobi promoting blood circulation and stopping pain, detumescence and promoting granulation, blood-nourishing stagnation resolvation, warming and activating meridian temporary solution dissolving stasis with
Control its hematogenous blockage；Lopseed, the dispelling wind and eliminating dampness of root of Chinese clematis temporary solution, tonneau channels and collaterals are to control rheumatic arthralgia；Ginger juice temperature leads to cold dispelling, the bletilla striata
Skin care, which reconciles, adheres to all medicines.Treating both manifestation and root cause of disease, play altogether warm sun ward off the cold, activating microcirculation and removing stasis medicinal, the effect of dispelling wind and eliminating dampness, swelling and pain relieving.Suit
The pathological characteristic for more stasis of bloods of trembling with fear Osteoarthritis in aged more.Clinical random paired observation statistics shows that VAS scoring front and back is compared and controls
Treatment group is substantially better than control group (P < 0.001), and WOMAC scoring front and back is compared wherein arthralgia, function of joint, machine synthesis and commented
Divide is treatment group better than control group (P < 0.001), it was demonstrated that it is arthralgic curative for effect that it treats cold stasis of blood type bone.Acupuncture point is applied
Pasting therapy is under the guidance of motherland's medicine theory of channels and collaterals, on the basis of diagnosis and treatment, by medicament plaster in the specific of body surface
Position, to treat a kind of method of disease.With the increase of endo-medicine therapy toxicity and drug resistance, point application therapy
It is increasingly subject to the attention of medical field colleague.There is the percutaneous of drug according to the meridian point application therapy that Chinese medicine meridian theory proposes
It absorbs and the double treatment characteristic of meridian point effect, medicine irritation part meridian point can excite whole body through gas, in part
The relative advantage of drug concentration is generated, and is conveyed by the absorptions of tiny blood vessels, maximum systemic pharmacologic effect is played, in this
Doctor's characteristic therapy ought to obtain clinical expansion and protection.
Claims (6)
1. a kind of Chinese medicine composition of external application application therapy Senior osteoarthritis, which is characterized in that it is by following parts by weight
Component be made: 10~20 parts of ramulus cinnamomi, 10~20 parts of rhizoma zingiberis, 5~10 parts of flos caryophylli, 10~20 parts of lopseed, radix aconiti lateralis preparata 10~
It is 20 parts, 15~30 parts of olibanum, 15~30 parts of myrrh, 20~40 parts of safflower, 10~20 parts of the root of Chinese clematis, 10~20 parts of Caulis Spatholobi, white
20~40 parts of splendid achnatherum, 50~100 parts of ginger.
2. the Chinese medicine composition of external application application therapy Senior osteoarthritis according to claim 1, which is characterized in that it
It is made of the component of following parts by weight: 10 parts of ramulus cinnamomi, 10 parts of rhizoma zingiberis, 5 parts of flos caryophylli, 10 parts of lopseed, 10 parts of radix aconiti lateralis preparata, cream
It is 15 parts, 15 parts of myrrh, 20 parts of safflower, 10 parts of the root of Chinese clematis, 10 parts of Caulis Spatholobi, 20 parts of the bletilla striata, 50 parts of ginger fragrant.
3. including the preparation side of the drug of the Chinese medicine composition of external application application therapy Senior osteoarthritis described in claim 1
Method, which is characterized in that it includes the following steps:
(1) by the radix aconiti lateralis preparata of formula ratio, ramulus cinnamomi, rhizoma zingiberis, flos caryophylli, olibanum, myrrh, lopseed, the root of Chinese clematis, safflower, Caulis Spatholobi
It is mixed with the bletilla striata, being ground into fine powder, to cross 80 meshes spare；
(2) ginger of formula ratio is minced plus the water of ten times of weight decocts twice, 30~60 minutes every time, filtration, merging filtrate,
It is concentrated to give gingerade；
(3) fine powder for obtaining step (1) is set and is gradually added the gingerade that step (2) obtains in U-shaped mixing channel, adds sweet
Oil and maltose are stirred, and paste is made until stirring evenly；
(4) by paste made of step (3) be uniformly applied on application film to get.
4. preparation method according to claim 3, which is characterized in that in step (2), be concentrated into 2~4 times of ginger weight
Gingerade.
5. the preparation method according to claim 4, which is characterized in that in step (3), the weight of gingerade, glycerol and maltose
Amount is than being 15~30:1~2:5~10.
6. the Chinese medicine composition of external application application therapy Senior osteoarthritis described in claim 1 treats senile bone in preparation
Application in arthritis drug.
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