CN109157569A - A kind of temperature pain is relaxed plastics and preparation method - Google Patents

A kind of temperature pain is relaxed plastics and preparation method Download PDF

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Publication number
CN109157569A
CN109157569A CN201811350723.9A CN201811350723A CN109157569A CN 109157569 A CN109157569 A CN 109157569A CN 201811350723 A CN201811350723 A CN 201811350723A CN 109157569 A CN109157569 A CN 109157569A
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pain
menthol
plastics
temperature
borneol
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李洋洋
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254—Acanthopanax or Eleutherococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268—Asarum (wild ginger)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/7007—Drug-containing films, membranes or sheets
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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Abstract

The invention belongs to technical field of traditional Chinese medicines, discloses a kind of temperature pain and relax plastics and preparation method；Component are as follows: ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, safflower 25g, root of Chinese clematis 15g, radix saposhnikoviae 15g, cortex acanthopanacis 15g, asarum 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Fructus Liquidambaris 10g, bombyx batryticatus 10g, menthol 3g, borneol 0.8g；In addition to menthol, borneol, add water spirit of vinegar tune pH value, decoct three times, herb liquid is mixed and filtered, and adds ethyl alcohol that alcohol content is made to reach 60%, is stood overnight, and is filtered.Polyvinyl alcohol separately is taken, appropriate amount of ethanol is added to dissolve, reserve liquid is added, adds menthol and glycerol, stirs evenly, adds ethyl alcohol to adjust total amount to 1000ml, the warm plastics that relax bitterly is made.The present invention is for blood stasis and swelling pain caused by traumatic injury, bruise etc.；DOMS；Rheumatic arthritis, scapulohumeral periarthritis, wind-cold-dampness arthralgia etc. be affected by the cold it is wet caused by local pain.

Description

A kind of temperature pain is relaxed plastics and preparation method
Technical field
The invention belongs to technical field of traditional Chinese medicines more particularly to a kind of easypro plastics of temperature pain and preparation methods.
Background technique
Currently, the prior art commonly used in the trade is such that
Rheumatic disease is a kind of common autoimmune disease, and major lesions position is joint, muscle, blood vessel, skin Skin and connective tissue, how indefinite the cause of disease is, clinical change multiterminal, with hereditary, immune, infection, metabolism, endocrine and environment etc. Factor is related, has the characteristics that multi viscera involvement and recurrent exerbation.Clinical manifestation often has fever, arthralgia, arthritis, easily accidentally It examines, fail to pinpoint a disease in diagnosis, illness rate is high, and crippling strong, treatment is difficult.
Patient with rheumatic disease has Tou Tong ﹑ Fa Re ﹑ Wei Han ﹑ E Feng ﹑ Shen Chong ﹑ little, and just the joint Bu Li ﹑ Suan Tong ﹑ cannot The symptoms such as bend and stretch, arthropathy in addition to having pain also with swelling and moving obstacle, in breaking-out with alleviate the alternate chronic course of disease. Since the blood circulation of patient is poor, nutrition required for leading to muscle or organizing can not be conveyed by blood circulation, be caused Patient muscle lacks nutrition and accelerated ageing becomes stiff, serious to will lead to patient muscle and blood vessel die back, and some patientss can Appearance joint is disabled and viscera function exhaustion.The drug for being used to alleviate arthralgia at present is various, though Western medicine is quick, It is big for the side effect of stomach, and have dependence, once be discontinued will recall pain, be used to the Chinese medicine of link arthralgia at present Pain relieving ointment effect is bad, and slow effect, action time is short, increases pain to patient.
In conclusion problem of the existing technology is:
(1) Western medicine has very big side effect to stomach, and easily forms dependence；Long-term Oral drug easily causes hepatic and renal function Damage.
(2) existing Chinese medicine pain relieving ointment slow effect, action time are shorter；For the surface bulges position such as joint, common plaster Moulding is difficult, it is difficult to make efficacy of a drug uniformly penetrating, absorb.
Summary of the invention
In view of the problems of the existing technology, the present invention provides a kind of easypro plastics of temperature pain and preparation methods.
The plastics the invention is realized in this way a kind of temperature pain is relaxed, component is ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, Safflower 25g, root of Chinese clematis 15g, radix saposhnikoviae 15g, cortex acanthopanacis 15g, asarum 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Fructus Liquidambaris 10g, bombyx batryticatus 10g, menthol 3g, borneol 0.8g.
Another object of the present invention is to provide the preparation method of the easypro plastics of warm pain, preparation step is as follows:
Step 1: high-quality genunie medicinal materials are chosen: ramulus cinnamomi, folium artemisiae argyi, lopseed, safflower, the root of Chinese clematis, radix saposhnikoviae, cortex acanthopanacis, thin Pungent, schizonepeta, myrrh, turpentine, Fructus Liquidambaris, bombyx batryticatus, menthol, borneol；
Step 2: precise ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, safflower 25g, root of Chinese clematis 15g, radix saposhnikoviae 15g, five Add skin 15g, asarum 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Fructus Liquidambaris 10g, bombyx batryticatus 10g, menthol 3g, borneol 0.8g；
Step 3: by ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, safflower 25g, root of Chinese clematis 15g, radix saposhnikoviae 15g, cortex acanthopanacis 15g, asarum 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Fructus Liquidambaris 10g, bombyx batryticatus 10g add suitable quantity of water, with spirit of vinegar tune Ph value To 4~5；
Step 4: three times by above-mentioned mixing decocting for Chinese herbal medicine, boiling one hour or so every time, and the herb liquid obtained every time is mixed And filter, filtrate is concentrated into 1.15, adds ethyl alcohol that alcohol content is made to reach 60% (to measuring optimum content), stands overnight, and filters It crosses, it is spare；
Step 5: separately taking polyvinyl alcohol 100g, add 50% appropriate amount of ethanol dissolve, above-mentioned reserve liquid is added, add menthol and Glycerol 8.5g, stirs evenly, add 50% ethyl alcohol adjust total amount to 1000ml to get.
In conclusion advantages of the present invention and good effect are as follows:
Folium artemisiae argyi, lopseed are monarch drug in a prescription in formula of the invention, being capable of warming and activating meridian analgesic；The positive dredging collateral of ramulus cinnamomi, asarum temperature, it is red Flower, myrrh promoting blood circulation and stopping pain, schizonepeta, radix saposhnikoviae, bombyx batryticatus dispelling wind and removing obstruction in the meridians, are ministerial drug above；Fructus Liquidambaris, the root of Chinese clematis, cortex acanthopanacis, pine Section, wind-damp dispelling are removed obstruction in channels to relieve pain, and are adjuvant；Menthol, borneol promote all medicines to absorb and prevent above all medicine pungent-warms too.
Temperature pain of the present invention relaxes plastics with warming and activating meridian, expelling wind and clearing away cold, stasis-dispelling and pain-killing.For traumatic injury, turn round It dampens；DOMS；Rheumatic arthritis, scapulohumeral periarthritis, wind-cold-dampness arthralgia etc. be affected by the cold it is wet caused by local pain.
Local administration of the present invention, the efficacy of a drug guide drugs to illness station, rapid compared with oral administration effect；It avoids being administered orally, exempts first mistake Effect avoids lesions of liver and kidney caused by Long-term Oral medicine；Long-term topical administration will not damage body.It is easy moulding, more compared with plaster It is easy to use.Prescription compatibility is fastidious, side Zhiduo County disease, warming and activating meridian, no pain by smooth breath.Part Chinese medicine is containing antianaphylaxis components (as prevented Wind, schizonepeta, folium artemisiae argyi etc.), prevent drug external application from causing allergic reaction.Part Chinese medicine has sedation (such as schizonepeta, ramulus cinnamomi), It can be relieved pain patients anxiety.
After menthol and borneol are included through β-CD (cyclodextrine, i.e. β-cyclodextrin abbreviation β-CD), thermostabilization Property can be significantly improved.It is steady during preparation and storage that research finds that β-cdinclusion helps to improve menthol and borneol It is qualitative.For production is containing menthol and borneol in the workshop for meeting GMP requirement, because reduction temperature is limited (18~26 DEG C), to the greatest extent Amount make technical process serialization to reduce the resting period of intermediate (particle and plain piece), be improve production process in menthol and The key measure of borneol retention rate.Plain piece is packed in time with aluminium foil, reserved sample observing 1 year under room temperature, the damage of menthol and borneol Mistake rate is 10% hereinafter, prompt can reduce the loss of menthol and borneol in finished product by preferred packaging material.Ring-type paste Smart (β-cyclodextrin abbreviation β-CD) is the product that starch is generated through acidolysis cyclisation.It can be with the various compounds of envelope point Son increases by inclusion complex to the stability of photo-thermal, oxygen, changes by the physicochemical property of envelope substance.Cycloheptaamylose is also known as ring wheat The sugar of bud seven, seven dextrin of ring, abbreviation β-CD, be extracted after microbial enzyme acts on starch made of by 7 glucose residues with The ring that β-Isosorbide-5-Nitrae-glycosidic bond is bonded, relative molecular mass 1135.It is compound that this product can form inclusion with multiple compounds Object makes its stabilization, solubilising, sustained release, emulsification, anti-oxidant, antidecomposition, heat preservation, moisture-proof, and has the effects that shelter peculiar smell, is new Type molecule lapping.
Detailed description of the invention
Fig. 1 is the preparation method flow chart of the easypro plastics of temperature pain provided in an embodiment of the present invention.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.
Temperature pain provided by the invention relaxes plastics by ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, safflower 25g, the root of Chinese clematis 15g, radix saposhnikoviae 15g, cortex acanthopanacis 15g, asarum 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Fructus Liquidambaris 10g, bombyx batryticatus 10g, peppermint Brain 3g and borneol 0.8g composition.
As shown in Figure 1, temperature provided in an embodiment of the present invention pain is relaxed plastics preparation method the following steps are included:
S101: high-quality genunie medicinal materials are chosen: ramulus cinnamomi, folium artemisiae argyi, lopseed, safflower, the root of Chinese clematis, radix saposhnikoviae, cortex acanthopanacis, asarum, Schizonepeta, myrrh, turpentine, Fructus Liquidambaris, bombyx batryticatus, menthol, borneol；
S102: precise ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, safflower 25g, root of Chinese clematis 15g, radix saposhnikoviae 15g, slender acanthopanax Skin 15g, asarum 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Fructus Liquidambaris 10g, bombyx batryticatus 10g, menthol 3g, borneol 0.8g；
S103: by ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, safflower 25g, root of Chinese clematis 15g, radix saposhnikoviae 15g, cortex acanthopanacis 15g, Asarum 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Fructus Liquidambaris 10g, bombyx batryticatus 10g add suitable quantity of water, with spirit of vinegar tune Ph value to 4~ 5；
S104: three times by above-mentioned mixing decocting for Chinese herbal medicine, boiling one hour or so every time, and the herb liquid obtained every time is mixed simultaneously Filtering, filtrate are concentrated into 1.15, add ethyl alcohol that alcohol content is made to reach 60% (to measuring optimum content), stand overnight, and filter, It is spare；
S105: separately taking polyvinyl alcohol 100g, adds 50% appropriate amount of ethanol to dissolve, above-mentioned reserve liquid is added, and adds menthol and sweet Oily 8.5g, stirs evenly, add 50% ethyl alcohol adjust total amount to 1000ml to get.
Application effect of the invention is explained in detail below with reference to specific clinical case.
(1) Lee, male are 49 years old, just medical in August, 2015.Readme right shoulder pain, weight more than three weeks, it is every to experience wind It is cold to aggravate.Physical examination is shown: tenderness around right shoulder joint, lifts on right upper extremity, extendes back limitation of activity.Remaining is without exception, is diagnosed as right shoulder Zhou Yan.Give warm pain easypro plastics after one week treatment, clinical symptoms improve；Symptom disappears after two weeks, and functional rehabilitation is normal.Follow-up Half a year is without recurrence.
(2) there is pain in the loins because catching cold before 67 years old, one week in Mr. Wang, male, and symptoms are mild does not give attention.Gradually waist activity afterwards It is limited, carry out my section's outpatient clinic in October, 2015.Symptom: waist-leg portion crymodynia, movable unfavorable, fixed pain do not subtract though reposing, It aggravates instead.Daytime light night weight pain increase in intensity under coldness, pain alleviated while getting warmth, normal urination, diarrhea with loose stool.The light fat whitish tongue of tongue nature is greasy, stringy and tense pulse.Then Lumbago diseases are diagnosed, are cold-dampness numbness type.Training checks that lumbar physiological-curvature straightens, and psoas muscle is nervous, without obvious lateral bending deformity.Waist 4- 5, tenderness (+) between 1 spine of waist 5- sacrum, spine side tenderness (+) are 60 degree of left side straight-leg raising test, 60 degree of right side straight-leg raising test, double Side " 4 " word test, femoral nerve stretching test, hip test (-) of bending the knee, lumbar vertebrae mobility can.Bilateral tendon reflex, Achilles jerk are just Often, double lower limb muscular strength, dermal sensation are shown no obvious abnormalities.It gives warm pain easypro plastics treatment, and patient is advised to notice that affected part is warming. After one week treatment, pain in the loins symptom is substantially reduced, activity still, treatment after two weeks, pain in the loins symptom disappear, waist normal activity not by Limit.
The pharmacological characteristics of the easypro plastics of temperature pain of offer of the invention are as follows:
Ramulus cinnamomi: acrid, sweet, warm enter lung, the heart, bladder meridian.Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi.Modern clinic is with this Product compatibility other medicine can be used for treating pain class disease caused by cold blood stasis, blockage of main and collateral channels.Contained cinnaldehydrum have analgesia, calmness, Anticonvulsant action.
Folium artemisiae argyi: pungent, bitter, temperature returns liver,spleen,kidney to pass through, warming channel for arresting bleeding, eliminating cold to stop pain；External application removing dampness to stop itchin；Compendium of Material Medica Record: Ai Yiye is used as medicine, and warm-natured, bitter, the property of nontoxic, pure sun, logical 12 pass through, have Hui Yang, rationale blood, by raw and other effects. " new compilation of materia medica " is said: " folium artemisiae argyi toil, raw temperature, ripe heat, the property of pure sun can return the exhausted sun that hangs down, and lead to 12 warps, walk three yin, qi-regulating Blood expels cold-dampness, and warms up uterus ... " " Mingyi Bielu ", have the function of " warming channel for arresting bleeding, eliminating cold to stop pain ".Folium artemisiae argyi water-extract components and Volatile oil has an analgesic activity, mechanism mainly with reduce prostaglandin E2 content in blood, adjust internal superoxide dismutase (SOD), malonaldehyde (MDA), NO level are related.In addition, pharmacological research is shown, folium artemisiae argyi also has anti-inflammatory, rush blood coagulation and anti-blood small Plate aggregation, the effect of anti-bacteria and anti-virus.
Lopseed: sweet, acrid, warm, return lung, liver two pass through.Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, promoting blood circulation and stopping pain, solution poison the function such as rash Effect.Dispelling wind and eliminating dampness, the product pungent-warm, pungent manage it scattered, temperature overcomes the coldness wet, and Compendium of Material Medica, which is said: lopseed " controls all rheumatalgia pains of muscles and bones Contracture "；Relaxing tendons and activating collaterals, " the sweet peaceful green Chinese herbal medicine choosing in Shan " select the product, control muscles and bones muscular constricture；Promoting blood circulation and stopping pain, the pungent scattered temperature of the product is logical, Enter Liver Channel blood system, therefore can promoting blood circulation and stopping pain.To up and down, trusted subordinate's waist and knee, inside and outside various pain can be selected the product and control it, Its pungent-warm is taken to be apt to walk, the function of promoting blood circulation and benefiting qi, vim and vigour no pain by smooth breath；Because there are also priming to penetrate channels and collaterals, blood vessels for this medicine washout, and dispel The characteristics of wind, promoting blood circulation, analgesic.The product and two medicine of turpentine have the effect of wind-damp dispelling, channels and collaterals living, but lopseed is arrested for muscles and bones partially The rheumatic arthralgia of contraction.Turpentine is used for the numbness and ache of cold dampness of joint joint stuffiness or arthroncus partially.
Safflower: nature and flavor: acrid in flavour and warm in nature." book on Chinese herbal medicine is new again ": enter liver, kidney two warp.Major function: blood circulation, stasis eliminatings analgesic." this Careless detailed outline ": promoting blood circulation is moisturized, and is relieved pain, and swollen, promoting menstruation is dissipated.Safflower has certain anti-inflammatory and antalgic activity.The study found that safflower methanol Extract and water extract have apparent analgesic activities.
The root of Chinese clematis: Xin Xian, temperature are toxic.Dispelling wind and eliminating dampness is removed obstruction in channels to relieve pain, dissolving phlegm water, dissipating the hypochondriac lump.Cure mainly stupid numbness of gout, rheumatism Numbness pain, extremity numbness, waist and knee crymodynia, muscle arteries and veins contraction, joint stuffiness, a lump in the abdomen causing distension and pain.There is certain toxicity because it is oral, external application has Targeting reduces drug toxicity, improves the features such as medicine stability.Transdermal diffusion experiment the result shows that, root of Chinese clematis flexibility lipid The accumulation transmitance of body is the several times of common drug, can significantly improve Drug Percutaneous Absorption rate.In addition, being directed to rheumatic arthralgia, limb Body is numb, muscle arteries and veins contraction, joint joint stuffiness, the person caused by cold-dampness, can with the compatibilities such as ramulus cinnamomi, with warming channel and expelling cold eliminating dampness.
Cortex acanthopanacis: acrid, bitter, warm returns liver and kidney channel.Its primary efficacy are as follows: wind-damp dispelling, strengthening the bones and muscles, diuresis.Limbs pain It is one of many disease common symptons of inside and outside traumatology, the cause of disease is mostly clinic caused by many reasons such as wind, cold, wet, the stasis of blood and wound On the patient that has be known as enterogastric diseases to movable blood soft hard, remove obstruction in channels to relieve pain, the Chinese medicines such as eliminating dampness class should not be used for a long time, outside decoction With method is easy, and patient gladly receives.According to the theory of " interior category internal organs, outer network podomere are linked up in table, and perforation is up and down ", slender acanthopanax The effect of skin is used alone or compatibility turpentine, the root of Chinese clematis, ramulus cinnamomi etc., can reach the promoting blood circulation reduction of fractions to a common denominator, relaxing muscles and tendons analgesic, dispelling wind and eliminating dampness.
Asarum: acrid in flavour and warm in nature.Return heart, lung, kidney channel.The effect of its antalgic, can be used for the muscle arthralgia that cold-evil enters network.Its With calm, analgesic activity, stronger analgesic activity is the valuable pharmacological basis of its treatment head bodily pain, toothache etc.." asarum The saying of but money " is long-standing, and in recent years, the article about asarum dosage usage is also seen in books and periodicals repeatedly, can obtain through analysis Out to draw a conclusion: when single is swallowed with end, dosage should be less than 3.125 grams, i.e. asarum only money；When being incorporated compound as decoction, It can take the circumstances into consideration dosage according to the state of an illness, it can be with to 6-15 grams.According to experimental study, asarum herb is after different time decocts, decocting liquid Middle volatile oil content increases with decocting time and is reduced.Asarum is decocting three ten minutes later, the content of toxic component safrole It can be greatly reduced, be not enough to cause to be poisoned, and we decoct and reach one hour every time.Therefore asarum " end is applied alone ", " asarum should be followed But money " is said, and entering decoction then can appropriate escalated dose.Our asarum is said for being applied with there is no toxicity one.
Radix saposhnikoviae: acrid flavour, sweet, slightly warm in nature return bladder, lung, spleen, Liver Channel, first recorded in Shennong's Herbal, meaning: " it is windproof, Taste sweet, warm.The main big dizzy pain of public attention, foul wind, ailment said due to cold or exposure, the wooden blindness are in fashion the whole body, and joint aches numbness, dysphoria." remember in book it is anti- The main syndrome of wind, disease because with " ailment said due to cold or exposure " it is related.The Compendium of Material Medica cloud of the Ming Dynasty: " radix saposhnikoviae is driven, and function is treated wind and most wanted, It is therefore named." later age think always radix saposhnikoviae be " it is general to control wind " medicine.Clinically radix saposhnikoviae mostly with the product of other wind-damp dispelling such as Wheeling Celestial, ramulus cinnamomi is equally used, to enhance the benefits of wind-damp dispelling is except numbness pain.The modern pharmacology proves that radix saposhnikoviae, in addition to having analgesic effect, there are also anti- Inflammation effect, therefore can be used for rheumatic arthralgia to reach anti-inflammatory analgesic effect.
Schizonepeta: acrid flavour, slightly warm in nature, return lung, Liver Channel, inducing diaphoresis relieve heat, promoting eruption, disappear sore；Volatile oil component contained by schizonepeta has Of flaccid muscles and antitetanic effect.In civil people often with schizonepeta treatment fever, rheumatalgia, contusion and fash etc., this and chaste tree Mustard is with anti-inflammatory, analgesic activity is related.Only volatile oil component can generate analgesic activity, schizonepeta volatilization in the chemical component of schizonepeta Oil has obvious anti-inflammatory, analgesic activity.Schizonepeta has calmness, can be relieved the anxiety of pain patients.
Another tool prevents external application from causing cutaneous anaphylaxis studies have shown that schizonepeta, radix saposhnikoviae have effects that antiallergy.
Myrrh: acrid flavour, hardship, mild-natured, return heart, liver, the spleen channel, scattered stasis pain, detumescence and promoting granulation；Myrrh is as in traditional simply Medicine, ancient Chinese find that it has analgesic activity, and amplification on Canon of Materia Medica is said: " myrrh probably leads to stagnant blood, beats and flutters damage pain, all with wine Change clothes.Then gas is stopped up solidifying for stasis, and gas stops up that solidifying then channels and collaterals are full anxious, and channels and collaterals are full anxious, therefore pain and swollen.All beat flutters muscle palpus struttuer, warp Network wound, qi and blood is not all right, stops up and coagulates, therefore in this way." analgesic activity has been also further demonstrated that in modern study, it is mainly contained not in myrrh Medicine volatile oil, poponax resin, natural gum, a small amount of amaroid simultaneously contain myrrholic acid, formic acid, the ingredients such as acetic acid and oxidizing ferment.Italy 3 kinds of sesquiterpene ingredients that Univ Firenze researcher extracts from African myrrh animal experiments show that: wherein extremely Rare 2 kinds of sesquiterpene constituents have strong analgesic activity.By studying the analgesic activity of myrrh difference extract, show do not have The volatile oil and alcohol extract+volatile oil of medicine have apparent analgesic activity to mouse, and alcohol extract+volatile oil analgesic activity ratio is waved Hair oil is strong, illustrates alcohol extract although itself is without analgesic activity, the analgesic activity of volatile oil can but be remarkably reinforced.
Turpentine: turpentine is bitter in taste, temperature, return liver warp.Effect is to dispel pathogenic wind and remove dampness, and is relieved pain.For main wind-cold-dampness arthralgia, severe and wadering arthralgia Bitterly；Foot numbness impotence is soft；Injuries from falls as well.Turpentine has certain analgesia, anti-inflammatory effect.
Fructus Liquidambaris: it is bitter, it puts down.Return liver and kidney channel.Dispelling, collateral-activating, Li Shui stimulates the menstrual flow.For arthralgia, numbness contracture, oedema is swollen It is full, the few menostasis of cream.Fructus Liquidambaris can eliminate painful swelling of joints, mitigate morning stiffness, and it is one that raising immune function etc. function and effect are obvious Kind resists the good medicine of all kinds of arthritis.
Bombyx batryticatus: bombyx batryticatus acrid flavour, salty, cold nature, function can relieving convulsion and spasm, wind-expelling pain-stopping, reducing phlegm and resolving masses, it is widely used." book on Chinese herbal medicine Detailed outline " cloud its can control " ... all metal-inflicted wounds of married woman's alactation ...." therefore, bombyx batryticatus should also have detumescence spasmolysis promoting blood circulation and removing obstruction in channels Function.Bombyx batryticatus washout can be used for brothers' muscular constricture, swelling, all diseases of crymodynia after apoplexy, and curative effect is rather good.Chinese medicine say " pathogen usually intruding into collateral in protracted disease ", " long The more stasis of bloods of disease ", because it is cold coagulate, with the passing of time blood stasis leads to pain, with the product of flesh and blood friendship it is salty, it is pungent enter network, promoting blood circulation, relieving swelling and pain.
Menthol is also referred to as menthol, is a kind of very important ring mushroom alcohol.Menthol natural origin is mainly that Labiatae is planted Main component in the volatile oil such as object peppermint and lavender can also be obtained by citronellal or thymol chemical synthesis.Menthol is normal The effects of being added in the external preparations such as skin, playing antipruritic part, analgesic, refrigerant and slight local anaesthesia.Discovered in recent years is thin Lotus brain has stronger transdermal enhancing effect, it is considered to be a kind of nontoxic, non-stimulated drug transdermal penetrating agent.At present to menthol Research is concentrated mainly on percutaneous dosing.
Borneol is one of traditional Chinese medicine, and Chinese medicine thinks borneol acrid flavour, hardship, and cold nature, return heart, spleen, lung are awake with having one's ideas straightened out The effect of mind leads to all keys, clearing away heat to and alleviating pain.Traditional Chinese medicine theory thinks that borneol " then gesture of walking alone is weak, and assistant makes then active " is " fragrant It walks to alter, priming uplink ".It is existing studies have shown that borneol " gesture of walking alone is not weak ", and " assistant makes also active ".In terms of walking alone, borneol has The effect of antibacterial, anti-inflammatory, analgesic, borneol can also promote concomitant medication through skin, mucous membrane, blood-eye barrier, blood-brain barrier It absorbs, influences internal pharmacokinetics, including absorption, distribution, metabolism of drug etc..
Borneol has specific anti-inflammatory, analgesic effect, when it can be by inhibiting the liver metabolism of drug, extending drug effect Between, to improve curative effect of medication.Menthol has the function of that refrigerant antipruritic, anti-inflammatory and antalgic and collaboration promote drug absorption.Borneol, Both menthols are generally mated use, cooperativing medicine-feeding.
Temperature provided by the invention pain relaxes plastics in use, take appropriate this product, by drug Direct Uniform be applied to affected part or Related acupuncture point uses 2~3 times, daily to the taboo of above-mentioned Chinese medicine component for skin allergy sufferers and affected part (painful area), skin injury It only uses, the pain such as rheumatic arthritis belong to red and swollen heat pain, should not use this product.This drug will seal storage, it should be noted that It is Protected from Heat, prevents fires.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.

Claims (5)

  1. The plastics 1. a kind of temperature pain is relaxed, which is characterized in that the temperature pain relaxes plastics by ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, safflower 25g, root of Chinese clematis 15g, radix saposhnikoviae 15g, cortex acanthopanacis 15g, asarum 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Lu Lu Logical 10g, bombyx batryticatus 10g, menthol 3g and borneol 0.8g composition.
  2. 2. a kind of based on the easypro plastics preparation method of temperature pain described in claim 1, which is characterized in that the easypro plastics of temperature pain Preparation method includes:
    Step 1: high-quality genunie medicinal materials: ramulus cinnamomi, folium artemisiae argyi, lopseed, safflower, the root of Chinese clematis, radix saposhnikoviae, cortex acanthopanacis, asarum, chaste tree are chosen Mustard, myrrh, turpentine, Fructus Liquidambaris, bombyx batryticatus, menthol, borneol；
    Step 2: weigh ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, safflower 25g, root of Chinese clematis 15g, radix saposhnikoviae 15g, cortex acanthopanacis 15g, Asarum 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Fructus Liquidambaris 10g, bombyx batryticatus 10g, menthol 3g, borneol 0.8g；
    Step 3: by ramulus cinnamomi 20g, folium artemisiae argyi 20g, lopseed 20g, safflower 25g, root of Chinese clematis 15g, radix saposhnikoviae 15g, cortex acanthopanacis 15g, thin Pungent 10g, schizonepeta 10g, myrrh 10g, turpentine 10g, Fructus Liquidambaris 10g, bombyx batryticatus 10g add water, with spirit of vinegar tune pH value to 4~5；
    Step 4: three times by above-mentioned mixing decocting for Chinese herbal medicine, boiling one hour every time, the herb liquid obtained every time mixed and filtered, Filtrate is concentrated into 1.15, adds ethyl alcohol that alcohol content is made to reach 60%, stands overnight, filtration, spare；
    Step 5: separately taking polyvinyl alcohol 100g, adds 50% appropriate amount of ethanol to dissolve, above-mentioned reserve liquid is added, adds menthol and glycerol 8.5g is stirred evenly, add 50% ethyl alcohol adjust total amount to 1000ml to get.
  3. The blood stasis and swelling pain caused by the treatment traumatic injury of plastics preparation, bruise 3. a kind of pain of the temperature as described in claim 1 is relaxed Drug.
  4. The drug of the treatment DOMS of plastics preparation 4. a kind of pain of the temperature as described in claim 1 is relaxed.
  5. Treatment rheumatic arthritis, the scapulohumeral periarthritis of plastics preparation 5. a kind of pain of the temperature as described in claim 1 is relaxed, wind-cold-dampness arthralgia sense The drug of local pain caused by wind-engaging cold-dampness.
CN201811350723.9A 2018-11-14 2018-11-14 A kind of temperature pain is relaxed plastics and preparation method Pending CN109157569A (en)

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Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
刘文: "《药用高分子材料学》", 30 June 2017, 中国中医药出版社 *
周志峰等: "《临床常见病特色针灸治疗》", 30 April 2018, 科学技术文献出版社 *
季海群: "中西医结合治疔胫腓骨骨折172例", 《辽宁中医杂志》 *
张龙君等: "中药熏洗治疗骨折或脱位术后关节僵硬", 《浙江中医学院学报》 *

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