CN105726793A - Swelling-dispersing and pain-relieving essential oil and preparing method thereof - Google Patents
Swelling-dispersing and pain-relieving essential oil and preparing method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0003—Compounds of unspecified constitution defined by the chemical reaction for their preparation
Abstract
The invention provides swelling-dispersing and pain-relieving essential oil. The swelling-dispersing and pain-relieving essential oil comprises, by volume, 90-100 parts of grape seed oil, 0.5-4 parts of rosemary oil, 0.1-2 parts of tea tree oil, 0.1-3 parts of basil oil, 0.2-0.4 part of cinnamon oil and 0.02-0.05 part of sage oil. A preparing method of the swelling-dispersing and pain-relieving essential oil includes the steps that rosemary oil, tea tree oil, basil oil, cinnamon oil and sage oil are put into a utensil according to the formula proportion and stirred to be even in the same direction, grape seed oil is added, the mixture is stirred in the same direction, and the swelling-dispersing and pain-relieving essential oil is obtained. According to the swelling-dispersing and pain-relieving essential oil and the preparing method thereof, the basil oil serves as a monarch medicinal material, the rosemary oil and the sage oil serve as minister medicinal materials, capacity of activating blood and removing stasis is high, and the monarch medicinal material is jointly assisted in achieving the effects of wound curing and pain relieving; the tea tree oil and the cinnamon oil are adjuvant medicinal materials, the grape seed oil is a guide medicinal material, and all the medicinal materials directly reach the diseased region; six kinds of medicinal materials are compatible and mainly used for relieving painn, cold dampness dispersing, meridian and collateral penetrating and qi and blood running are carried out accordingly, and the effects of blood activating, blood stasis dispersing, meridian promoting, collateral dredging, swelling dispersing and pain relieving are jointly achieved.
Description
Technical field
The present invention relates to a kind of plants essential oil and preparation method thereof, be specifically related to a kind of quintessence oil and preparation method thereof that relieves the pain of subsiding a swelling.
Background technology
Orthopedics department soft tissue injury and osteoarthrosis, often with local swelling pain for principal character, be one of common pain of the traditional Chinese medical science.Often caused by motion improper, traumatic injury, work impairment caused by overstrain and rheumatism muscle and tendon injury etc..Its pathogenesis be summed up always belong to blood-stasis internal-depression, cold-damp is attacked to, grain obstructed.The traditional Chinese medical science thinks that " not bitterly, pain is then obstructed for general rule." damage of soft tissue in orthopedics department, it is commonly referred to as " muscle and tendon injury ", is the most common in traumatology illness.The soft tissues such as tendon are the piths in composition joint, and all traumatic injury, muscle often stands in the breach, and injured chance is maximum.Clinically, after all spraining, dampening, bones and muscles injury can be caused, partial gall, livid purple, joint joint stuffiness.In bone injury, owing to the soft tissues such as tendon adhere to its surface, tendon is also often first injured, and sees local swelling, silt green grass or young crops, joint stuffiness.Studying carefully its pathogenesis mostly to be damage and cause qi and blood stagnation, grain blocks, obstructed and pain.The method that the muscle that cures the wound swells and ache, the traditional Chinese medical science have accumulated rich experience, is probably divided into: acute stage is based on promoting blood circulation to remove blood stasis, subduing swelling and relieving pain；Chronic injury, then should dual-purpose temperature three-way meridian
The pain that osteoarthritis causes is also for one of common pain.It is quite wide that osteoarthritis includes scope, such as bone joint degeneration, hyperosteogeny, osteoporosis, rheumatic arthritis, gout and osteoarticular injury etc..The traditional Chinese medical science is belonged to the category of " arthromyodynia ".Ancients call " numbness person closes also ", refer to the inaccessible obstructed meaning of meridians, QI and blood."Nei Jing" thinks that " gas that wind and cold is wet is assorted extremely, combined into numbness ", its cause of disease are that exopathogen is attacked and arrived because of positive QI-insufficiency, striae of the skin and muscles being loose, and pathogenesis is suitable blockage of main and collateral channels then, stagnation of QI-blood, and battalion defends not freely for feature.Control method, focus on dredging the meridian, blood-activating and qi-promoting, help with the logical cold expelling of temperature, expelling wind and dampness, make heresy go ruton, QI-blood circulation, then swell and ache from disappearing.
Detumescence on the market relieves the pain the solvent extract that active component is Chinese herbal medicine of medicine, and Transdermal absorption ability, effect is very not good.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of quintessence oil and preparation method thereof that relieves the pain of subsiding a swelling.
Technical scheme provided by the invention is a kind of quintessence oil that relieves the pain of subsiding a swelling, including the component of volumes below part:
Oleum Vitis viniferae 90～100 parts, oil of rosemary 0.5～4 part, tea tree oil 0.1～2 part, basil oil 0.1～3 part, Oleum Cinnamomi 0.2～0.4 part, sage oil 0.02～0.05 part.
Rosemary ethereal oil is the volatile oil extracted from the flower and leaf of Labiatae shrub Herba Rosmarini Officinalis Rosmarinusofficinalis, the effect have pain relieving, stimulating the menstrual flow.
Tea tree oil is the volatile oil extracted from the leaf of Myrtaceae paperbark, has effect of wind-expelling pain-stopping, functions of detumescence, relieving inflammation.
Basil oil is the volatile oil that labiate Herba Ocimi (Herba Ocimi Pilosi) OcimumbasilicumL herb extracts.Having dispelling wind to relieve the exterior syndrome, removing dampness for regulating stomach, dispel the wind detumescence, eliminating stasis to stop pain, promoting blood circulation to restore menstrual flow.
Oleum Cinnamomi dispelling cold by warming the meridian, reducing swelling and alleviating pain, thoroughly reach space between skin and muscles.
Sage oil, for labiate Salvia japonica Thunb. Salviaofficinalis herb extract volatile oil, there is the effect of analgesia, antiinflammatory, promoting blood flow to regulate menstruation.
Oleum Vitis viniferae is the volatile oil of the seed of vitaceae Fructus Vitis viniferae VitisviniferaL..Easily absorb, based on oil.
Above-mentioned quintessence oil can pass through steam distillation, squeezing and pressing method, cold-maceration or solvent extraction method and refine the volatility direction material extracted.These quintessence oils can be commercially available respectively, it is possible to extracts preparation voluntarily according to the method for prior art.Each quintessence oil in the present invention should meet associated treatment standard-required.
As preferably, the parts by volume of each component is: Oleum Vitis viniferae 95～100 parts, oil of rosemary 0.5～1 part, tea tree oil 0.1～0.5 part, basil oil 0.1～0.3 part, Oleum Cinnamomi 0.2～0.3 part, sage oil 0.04～0.05 part.
It is further preferred that the parts by volume of each component is: Oleum Vitis viniferae 98.405 parts, oil of rosemary 0.8 part, tea tree oil 0.3 part, basil oil 0.2 part, Oleum Cinnamomi 0.25 part, sage oil 0.045 part.
Present invention also offers above-mentioned detumescence to relieve the pain the preparation method of quintessence oil, put in vessel by the oil of rosemary of formula ratio, tea tree oil, basil oil, Oleum Cinnamomi and sage oil, stir to same direction, add Oleum Vitis viniferae, same direction is stirred, and to obtain final product.
The using method of the quintessence oil of the present invention, is applied in affected part by 1～5ml quintessence oil, within one day, smears once.
Compared with prior art, the method have the advantages that
The present invention is with basil oil for monarch, with oil of rosemary and sage oil for minister, blood circulation promoting and blood stasis dispelling ability is strong, and principal drug assistance cures the wound pain relieving, tea tree oil and Oleum Cinnamomi for assistant altogether, Oleum Vitis viniferae is for making, guiding all medicines to go directly diseased region, 6 medicine compatibilities, based on pain, make cold-damp dissipate, through ruton, QI and blood row, amount to promoting blood circulation to remove blood stasis, the effect relieved the pain through dredging collateral, detumescence of relaxing.
Detailed description of the invention
The present invention is further elaborated for specific examples below, but not as a limitation of the invention.
Embodiment 1
Formula: Oleum Vitis viniferae 90ml, oil of rosemary 0.5ml, tea tree oil 0.1ml, basil oil 0.1ml, Oleum Cinnamomi 0.2ml, sage oil 0.02ml.
Preparation method: put in vessel by the oil of rosemary of formula ratio, tea tree oil, basil oil, Oleum Cinnamomi and sage oil, stirs to same direction, adds Oleum Vitis viniferae, and same direction is stirred, and to obtain final product.
Embodiment 2
Formula: Oleum Vitis viniferae 100ml, oil of rosemary 1ml, tea tree oil 0.5ml, basil oil 0.3ml, Oleum Cinnamomi 0.3ml, sage oil 0.05ml.
Preparation method: put in vessel by the oil of rosemary of formula ratio, tea tree oil, basil oil, Oleum Cinnamomi and sage oil, stirs to same direction, adds Oleum Vitis viniferae, and same direction is stirred, and to obtain final product.
Embodiment 3
Formula: Oleum Vitis viniferae 98.405ml, oil of rosemary 0.8ml, tea tree oil 0.3ml, basil oil 0.2ml, Oleum Cinnamomi 0.25ml, sage oil 0.045ml.
Preparation method: put in vessel by the oil of rosemary of formula ratio, tea tree oil, basil oil, Oleum Cinnamomi and sage oil, stirs to same direction, adds Oleum Vitis viniferae, and same direction is stirred, and to obtain final product.
Embodiment 4
Formula: Oleum Vitis viniferae 100ml, oil of rosemary 4ml, tea tree oil 2ml, basil oil 3ml, Oleum Cinnamomi 0.4ml, sage oil 0.05ml.
Preparation method: put in vessel by the oil of rosemary of formula ratio, tea tree oil, basil oil, Oleum Cinnamomi and sage oil, stirs to same direction, adds Oleum Vitis viniferae, and same direction is stirred, and to obtain final product.
Experimental example
1, on the impact that mouse knoting oil ear is swollen
Select male mice in kunming 60, body weight 18～22g, be randomly divided into 6 groups, respectively negative control group, positive controls 1,2 and experimental group 1～3, often group 10.The each group of left auricular concha of mice drips Oleum Tiglii proinflammatory agent 0.05ml, after causing scorching 5min and 10min, causes coating on scorching auricular concha each group of mice.Experimental group 1～3 is smeared the detumescence of experimental example 1～3 respectively and is relieved the pain quintessence oil, and dosage is 0.2ml/kg；Negative control group is coated with oil for injection, and dosage is 0.2ml/kg；Positive controls 1 smears repercussive and analgesic tincture (Huahong Pharmaceutical Co., Ltd., Guangxi, lot number: 021124), and dosage is 2ml/kg body weight.Positive controls 2 smears the composite essential oil being made up of oil of rosemary, basil oil and Oleum Cinnamomi, and its volume ratio is 1:1:1, and dosage is 0.2ml/kg.Put to death mice after 2h, cut left and right ear, lay same position auricle with diameter 9mm card punch, weigh；Mus dropsy of ear degree is made with the difference of left and right auricle weight.The average taking each administration group compares with matched group, carries out statistical test, and result is shown in table 1 below.
The impact that mouse knoting oil ear is swollen by table 1
| Group | Animal (only) | Ear swells degree (mg) |
| Negative control group | 10 | 18.389±3.740 |
| Positive controls 1 | 10 | 11.278±5.239* |
| Positive controls 2 | 10 | 16.108±4.328* |
| Experimental group 1 | 10 | 6.1000±4.717** |
| Experimental group 2 | 10 | 4.890±4.622** |
| Experimental group 3 | 10 | 4.440±3.459** |
Compared with negative control group, * p < 0.05, * * p < 0.01.
As shown in Table 1, the antiinflammatory action highly significant that mouse knoting oil ear is swollen by experimental group.
2, on the impact that rat carrageenan foot is swollen
Choose 60 Wistar kind male rats, body weight 150～170g, be randomly divided into 6 groups, respectively negative control group, positive controls 1,2 and experimental group 1～3, often group 10.First measure 0.5cm place diameter under every rat right hind leg ankle joint with projector (amplifying 6 times), make normal value.Then after every Rat Right, toes are to ankle joint position coating, and experimental group 1～3 is smeared the detumescence of experimental example 1～3 respectively and relieved the pain quintessence oil, and dosage is 0.2ml/kg；Negative control group is coated with oil for injection, and dosage is 0.2ml/kg；Positive controls 1 smears repercussive and analgesic tincture (Huahong Pharmaceutical Co., Ltd., Guangxi, lot number: 021124), and dosage is 2ml/kg body weight.Positive controls 2 smears the composite essential oil being made up of oil of rosemary, basil oil and Oleum Cinnamomi, and its volume ratio is 1:1:1, and dosage is 0.2ml/kg.30min after coating medicine-feeding, after every Rat Right, sc1% lrish moss mucilage 0.05ml in foot pad portion causes inflammation, respectively after causing inflammation 0.5,1,2,3 and 4h survey rat with projector again and cause the diameter under scorching limb ankle joint so that the difference before and after scorching makes the degree that rat foot is swollen.Taking the average of each administration group compared with matched group, carry out statistics test, result is in Table 2.
Table 2 detumescence relieves the pain quintessence oil to the sufficient swollen impact of rat carrageenan
Compared with negative control group, * p < 0.05, * * p < 0.01.
As shown in Table 2, the detumescence of experimental group relieves the pain quintessence oil to the swollen antiinflammatory action of rat carrageenan foot significantly, rapid-action, long action time.
3, the impact on rat assist agent arthritis
Choose 60 Wistar kind male rats, body weight 150～170g, be randomly divided into 6 groups, respectively negative control group, positive controls 1,2 and experimental group 1～3, often group 10.The preparation of adjuvant is to be added in the incomplete freund adjuvant of sterilizing by the bacillus calmette-guerin vaccine inactivated in advance, grinds and makes the adjuvant that concentration is 10mg/ml.Model be prepared by foot pad portion sc0.01ml adjuvant after every Rat Right, the generation of induced arthritis.
1) impact on novo lesions: first measure 0.5cm place diameter under every rat right hind leg ankle joint with projector (amplifying 6 times), make normal value.After Rat Right, toes are to ankle joint position coating, and experimental group 1～3 is smeared the detumescence of experimental example 1～3 respectively and relieved the pain quintessence oil, and dosage is 0.2ml/kg；Negative control group is coated with oil for injection, and dosage is 0.2ml/kg；Positive controls 1 smears repercussive and analgesic tincture (Huahong Pharmaceutical Co., Ltd., Guangxi, lot number: 021124), and dosage is 2ml/kg body weight；Positive controls 2 smears the composite essential oil being made up of oil of rosemary, basil oil and Oleum Cinnamomi, and its volume ratio is 1:1:1, and dosage is 0.2ml/kg.Every day 1 time, successive administration 4d, after being administered in the 2nd time, 30min injection adjuvant causes inflammation, after causing inflammation 18h and 3,6,8d survey rat with projector again and cause the diameter under scorching limb ankle joint so that the difference before and after scorching makes the degree that rat foot is swollen.Taking the average of each administration group compared with matched group, carry out statistics test, result is in Table 3.
Table 3 detumescence relieves the pain the quintessence oil impact on rat assist agent arthritis novo lesions
Compared with negative control group, * p < 0.05, * * p < 0.01.
As shown in Table 3, the detumescence of the experimental group quintessence oil that relieves the pain is notable to the antiphlogistic effects effect of rat assist agent arthritis novo lesions.
2) impact on secondary arthritis: the 8th day after adjuvant injection starts coating, and dosage ibid, divides and is applied to two back foot parts, every day 1 time, successive administration to the 30th day, observe the quintessence oil preventive and therapeutic effect to secondary arthritis that relieves the pain of subsiding a swelling.From self administration of medication, every 4～5d, with the left back vola thickness of miking (adjuvant injection offside), in units of mm, make the index of secondary arthritis swelling.The average taking each administration group compares with matched group, carries out statistical test.
Table 4 detumescence relieves the pain the quintessence oil impact on rat assist agent arthritis secondary arthritis
Compared with negative control group, * p < 0.05, * * p < 0.01.
As shown in Table 4, adjuvant injection is also had significant preventive and therapeutic effect to parapodum is swollen by the detumescence quintessence oil that relieves the pain, it was shown that this quintessence oil can organize and alleviate the generation of rat assist agent arthritis secondary arthritis.
4, the impact on the reaction of mice acetic acid twisting
Choose 60 Kunming mouses, be randomly divided into 6 groups, respectively negative control group, positive controls 1,2 and experimental group 1～3, often group 10, male and female half and half.Abdominal part cropping coating, experimental group 1～3 is smeared the detumescence of experimental example 1～3 respectively and is relieved the pain quintessence oil, and dosage is 0.2ml/kg；Negative control group is coated with oil for injection, and dosage is 0.2ml/kg；Positive controls 1 smears repercussive and analgesic tincture (Huahong Pharmaceutical Co., Ltd., Guangxi, lot number: 021124), and dosage is 2ml/kg body weight；Positive controls 2 smears the composite essential oil being made up of oil of rosemary, basil oil and Oleum Cinnamomi, and its volume ratio is 1:1:1, and dosage is 0.2ml/kg.30min every ip in mice 0.6% acetum 0.2ml induced pain after every medicine, with the writhing number of times of every mice in the 2nd 10min of counter records.Calculating each average writhing number of administration group mice to compare with matched group, carry out statistical test, result is in Table 5.
Table 5 detumescence relieves the pain the impact that mice acetic acid twisting reacts by quintessence oil
| Group | Animal (only) | Writhing number of times |
| Negative control group | 10 | 31.800±12.577 |
| Positive controls 1 | 10 | 9.375±7.708* |
| Experimental group 1 | 10 | 6.571±8.121** |
| Experimental group 2 | 10 | 5.857±8.123** |
| Experimental group 3 | 10 | 4.143±4.451** |
Compared with negative control group, * p < 0.05, * * p < 0.01.
As shown in Table 5, detumescence relieves the pain the quintessence oil analgesic activity highly significant to chemical stimulation.
5, the impact of mice water-bath whipping reaction
Choose 60 Kunming mouses, be randomly divided into 6 groups, often group 10, respectively negative control group, positive controls 1,2 and experimental group 1～3, often group 10, male and female half and half.Experimental group 1～3 is smeared the detumescence of experimental example 1～3 respectively and is relieved the pain quintessence oil, and dosage is 0.2ml/kg；Negative control group is coated with oil for injection, and dosage is 0.2ml/kg；Positive controls 1 smears repercussive and analgesic tincture (Huahong Pharmaceutical Co., Ltd., Guangxi, lot number: 021124), and dosage is 2ml/kg body weight；Positive controls 2 smears the composite essential oil being made up of oil of rosemary, basil oil and Oleum Cinnamomi, and its volume ratio is 1:1:1, and dosage is 0.2ml/kg.Often respectively before mouse tail coating and after coating 0.5,1 and 2h side mice whipping response latency in the water bath with thermostatic control of 55 ± 0.5 DEG C, as the threshold of pain index of analgesic activity.The average taking each administration group compares with matched group, carries out statistical test, and result is in Table 6.
Table 6 detumescence relieves the pain the impact that mice water-bath whipping reacts by quintessence oil
Compared with negative control group, * p < 0.05, * * p < 0.01.
As shown in Table 6, the detumescence quintessence oil that relieves the pain can significantly improve the pain threshold that warm is stimulated by mice, and its analgesic activity is than the better effects if of positive controls, and rapid-action and long action time.
6, the analgesic activity to mice electricity irritation
Choose 60 female KM kind mices, be randomly divided into 6 groups, often group 10 respectively negative control group, positive controls 1,2 and experimental group 1～3, often group 10.Experimental group 1～3 is smeared the detumescence of experimental example 1～3 respectively and is relieved the pain quintessence oil, and dosage is 0.2ml/kg；Negative control group is coated with oil for injection, and dosage is 0.2ml/kg；Positive controls 1 smears repercussive and analgesic tincture (Huahong Pharmaceutical Co., Ltd., Guangxi, lot number: 021124), and dosage is 2ml/kg body weight；Positive controls 2 smears the composite essential oil being made up of oil of rosemary, basil oil and Oleum Cinnamomi, and its volume ratio is 1:1:1, and dosage is 0.2ml/kg.What often before mice foot coating and after coating 1,2, mice was placed on the YSD-4 type multiplex instrument of pharmacology Physiological Experiment by 3h respectively enrages survey pain threshold (70V, 8Hz stimulation mode in conjunction, stimulation time 1s), with start power supply to mice send the first hoarseness between incubation period make index.The average taking each group compares with the pain threshold before administration, carries out statistical test, and result is in Table 7.
Table 7 detumescence relieves the pain the quintessence oil impact on the analgesic activity of mice electricity irritation
Compared with negative control group, * p < 0.05, * * p < 0.01.
As shown in Table 7, the detumescence quintessence oil that relieves the pain can significantly improve the mice pain threshold to electricity irritation, and analgesic activity is far beyond positive controls.
Claims (4)
1. a detumescence relieves the pain quintessence oil, it is characterised in that: include the component of volumes below part: Oleum Vitis viniferae 90～100 parts, oil of rosemary 0.5～4 part, tea tree oil 0.1～2 part, basil oil 0.1～3 part, Oleum Cinnamomi 0.2～0.4 part, sage oil 0.02～0.05 part.
2. detumescence according to claim 1 relieves the pain quintessence oil, it is characterised in that: the parts by volume of each component is: Oleum Vitis viniferae 95～100 parts, oil of rosemary 0.5～1 part, tea tree oil 0.1～0.5 part, basil oil 0.1～0.3 part, Oleum Cinnamomi 0.2～0.3 part, sage oil 0.04～0.05 part.
3. detumescence according to claim 2 relieves the pain quintessence oil, it is characterised in that: the parts by volume of each component is: Oleum Vitis viniferae 98.405 parts, oil of rosemary 0.8 part, tea tree oil 0.3 part, basil oil 0.2 part, Oleum Cinnamomi 0.25 part, sage oil 0.045 part.
4. the detumescence according to any one of claims 1 to 3 relieves the pain the preparation method of quintessence oil, it is characterized in that: the oil of rosemary of formula ratio, tea tree oil, basil oil, Oleum Cinnamomi and sage oil are put in vessel, stir to same direction, add Oleum Vitis viniferae, same direction is stirred, and to obtain final product.
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Cited By (3)
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| CN108567862A (en) * | 2018-07-04 | 2018-09-25 | 范加家 | Mite killing is releived compound borneol essential oil and preparation method thereof |
| CN109528563A (en) * | 2019-01-02 | 2019-03-29 | 潍坊市中意桥医药科技有限公司 | A kind of vegetable oil composition |
| WO2021013315A1 (en) * | 2019-07-22 | 2021-01-28 | Mostafa Mariam Mohamed Kamel | Ointment for diabetic foot ulcer treatment |
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| WO2021013315A1 (en) * | 2019-07-22 | 2021-01-28 | Mostafa Mariam Mohamed Kamel | Ointment for diabetic foot ulcer treatment |
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