KR20150060487A - Oriental plant extracts for attenuating pain - Google Patents

Abstract

The present invention relates to an herbal composition for pain relief comprising herbal extracts and, more specifically, to an herbal composition for topical administration, which contains mixed extracts of herbal medicine and has an effect of alleviating muscle or joint pain. The herbal composition for pain relief, in accordance with the present invention, provides effects of aeremia and blood circulation amelioration, muscle and joint relaxation, pain relief and the like by being applied to a muscle or joint area.

Description

[0001] Oriental plant extracts for attenuating pain [0002]

The present invention relates to a herbal composition for relieving pain comprising an oriental herbal extract, more specifically to a herbal composition for topical administration, which comprises a mixed extract of various oriental medicinal herbs and has a pain relieving effect of muscles or joints.

Pain relief can be accomplished in two ways. One method is to mask the pain from the patient, although the cause of the pain continues. This is the mode of action of many anesthetics. These analgesics prevent the patient from feeling pain, but they do not block the underlying cause of analgesia, so it is required that the analgesic is administered continuously. Another method of pain relief that is more efficient is to solve pain-causing causes. That is, when the physiological or neurotransmitter of pain is relieved, the sense of pain is reduced.

On the other hand, oral painkillers such as painkillers are generally administered. However, currently developed pain relief agents for oral administration tend to cause various side effects such as liver damage, kidney damage, gastrointestinal injury, poisoning and weight gain. In addition, in the case of the pain relief agent for oral administration, since it has to be absorbed through the digestive system before entering the bloodstream, it takes some time to exert its effect. Parenteral administration methods such as intravenous infusion or intramuscular injection methods have been proposed to solve the delay problem of oral administration, but these methods are not convenient and costly, There is an inconvenient problem.

Accordingly, attempts have been made to administer pain relievers in a topical, especially transdermal, manner, and attempts have been made to develop drugs and / or pharmaceutical compositions suitable for transdermal administration.

However, up to now, only development of a pain relieving agent for transdermal administration using a chemical agent has been made, and it is possible to obtain pain relief in a short time, but it has a problem of irritating the skin. Therefore, currently, attempts have been made to develop hypotonic transdermal pain relieving agents for skin. However, since the kinds and effects of the natural herbal ingredients are various, there is little research on whether the natural functional ingredients can be provided to the human body when mixed with natural herbal ingredients.

Korean Patent Publication No. 2005-0013894

It is an object of the present invention to provide a pain-relieving herbal composition which provides effects such as mere blood communication, blood circulation improvement, muscular and joint relaxation and pain relief by applying to muscles or joints.

According to one aspect of the present invention, there is provided a method for producing a polyurethane foam comprising: 8 to 12 parts by weight of a white god; 8 to 12 parts by weight of kerosene; 8 to 12 parts by weight of perfume; 8 to 12 parts by weight; 8 to 12 parts by weight of Seok Changpo; 8 to 12 parts by weight of ground paper; 8 to 12 parts by weight of acidophilus; 8 to 12 parts by weight of cordierite; 8 to 12 parts by weight of peppermint; And 14 to 18 parts by weight of soft meat, as an active ingredient, may be provided.

In one embodiment, the herbal composition may comprise at least one selected from the group consisting of thickeners, purified water, moisturizers, alcohol solvents, emulsifiers, chelating agents and hyaluronic acid.

In one embodiment, the herbal composition comprises 45 to 75 parts by weight of the herbal extract; From 30 to 35 parts by weight of an increasing amount; 6 to 10 parts by weight of purified water; 4 to 6 parts by weight of a moisturizer; 4 to 6 parts by weight of an alcohol solvent; 1 to 2 parts by weight of an emulsifier; 0.5 to 1.5 parts by weight of a chelating agent; And 1 to 3 parts by weight of hyaluronic acid.

In one embodiment, the herbal composition is selected from the group consisting of lavender oil, peppermint oil, tea tree oil, rosemary oil, orange oil, lemon grass oil, eucalyptus oil, chamomile oil, citronella oil, frankincense oil, 0.0 > 1 < / RTI > to 0.5 parts by weight of at least one natural oil selected from the group consisting of palmarose oil and parchment oil.

The pain-relieving herbal composition according to the present invention is applied to muscles or joints, thereby providing effects such as communication of mere blood, improvement of blood circulation, relaxation of muscles, joints, and pain relief.

Figure 1 shows the VAS values of the experimental group and the control group treated with the herbal composition according to the present invention.
Figure 2 shows the change in the VAS value of the experimental group and the control group treated with the herbal composition according to the present invention.

Hereinafter, the present invention will be described in more detail.

Unless otherwise defined herein, scientific and technical terms used in connection with the present invention shall have the meanings commonly understood by one of ordinary skill in the art. In addition, unless the context clearly indicates otherwise, the singular form of the term includes plural forms thereof, and the plural form of terms will also include its singular form.

According to one aspect of the present invention, there is provided a method for producing a polyurethane foam comprising: 8 to 12 parts by weight of a white god; 8 to 12 parts by weight of kerosene; 8 to 12 parts by weight of perfume; 8 to 12 parts by weight; 8 to 12 parts by weight of Seok Changpo; 8 to 12 parts by weight of ground paper; 8 to 12 parts by weight of acidophilus; 8 to 12 parts by weight of cordierite; 8 to 12 parts by weight of peppermint; And 14 to 18 parts by weight of soft meat, as an active ingredient, may be provided.

In one embodiment, the herbal extract comprises the steps of: (a) growing a mixture of herbal materials at 1 to 2 atm, 100 to 200 ° C for 1 to 2 hours; (b) drying the roughened mixture at 70 to 90 DEG C for 3 to 4 hours; And (c) adding water or an alcohol to the dried mixture and subjecting the mixture to hot extraction at 100 to 200 DEG C for 2 to 3 hours.

In one embodiment, the herbal extract further comprises an extract of at least one herbal material selected from ginseng, sorghum, wooze, Korean herb, ginseng, white seaweed, red seaweed, manganese, hyphae, mesophyll, can do. The herbal material is not limited to the above examples, but it is preferably a herbal material which can exhibit a significant effect on pain relief of muscles or joints together with the composition according to the present invention.

Herein, the characteristics of the herbal medicine used for constructing the herbal extract are as follows.

① White Blood God: It is the root of Pachyma hoelen (= Poria cocos), which strengthens the spleen, strengthens the middle spleen, removes the moisture, helps the sap metabolism and stabilizes the mind.

② Kill: Phyllostachys nigra var henonis, Phyllostachys bambusoides (= Bambusa textilis), Bambusa tuldoides, Sinocalamus beecheyanus var pubesceus, and remove the surface of the pubesceus, It removes the phlegm and removes the phlegm and stops the vomiting.

③ Ancestral Root: Root stalk of Cyperus rotundus has the effect of eliminating the cold and treating all kinds of mental neurological diseases including side-impact pain and depression caused by liver function disorder.

④ Impregnation: There is an efficacy of picnic, 清热, paranormal, nominal, and detoxification.

⑤ Seokchangpo: Acorus gramineus var variegatus, Acorus gramineus, Acorus tatarinowii, root of stomach, to remove the sputum, help the circulation of the 气, It has the effect of eliminating the wind and removing the wind.

⑥ Origin (farji): It is a perennial herbaceous plant belonging to the Department of Oriental Medicine, and has gigantism and mental stability.

⑦ Sanjoin: Zizyphus jujuba var. It is a seed of spinosa and Zizyphus jujuba (= Zizyphus vulgaris var. spinosus) which nourishes the liver, calms the mind, stabilizes the mind, and absorbs sweat.

⑧ Hwangryeong (黄连): Coptis (teeta, japonica, chinensis, deltoidea, omeiensis) root of the roots, to remove the fire, remove the ((濕) detoxification and parasitic relief is effective.

⑨ Mint: It has effects such as fever, inflammation, dryness, promotion of bile secretion and suppression of gastric smooth muscle, increase of mucus secretion of the respiratory tract, excitement of the central nervous system, and contraction of the uterus.

⑩ Lentil meat: The ripe fruit and seed of Nelumbo nucifera (= Nelumbo nymphaea) are bibby (补脾), branch (泻肾 固 精), conscientious ansheng It has efficacy.

In one embodiment, the herbal composition may comprise at least one member selected from the group consisting of thickeners, purified water, moisturizers, alcohol solvents, emulsifiers, chelating agents and hyaluronic acid. For example, Weight part; From 30 to 35 parts by weight of an increasing amount; 6 to 10 parts by weight of purified water; 4 to 6 parts by weight of a moisturizer; 4 to 6 parts by weight of an alcohol solvent; 1 to 2 parts by weight of an emulsifier; 0.5 to 1.5 parts by weight of a chelating agent; And 1 to 3 parts by weight of hyaluronic acid.

In one embodiment, the thickening agent may contain 30 to 35 parts by weight of a component for maintaining the gel type by imparting appropriate tackiness when the herbal composition is stored at room temperature. In addition, the thickener may be provided as a mixture, for example, as carbomer (hydrogel) and triethanolamine (gel assist).

In one embodiment, the purified water may be distilled by a chemical or physical method, or purified water through an ion exchange resin, and may be used in an amount of 6 to 10 parts by weight. In addition, the purified water preferably has a pH of about 7, and may further include a pH adjusting agent for controlling the pH of the purified water.

In one embodiment, the humectant (or wetting agent) may be provided in glycerine or glycolated form and may be provided as a mixture of glycerin and glycols. In this case, the weight ratio of glycerin to glycol is preferably 1: 1.

In one embodiment, the alcohol solvent may be provided as a mixture of ethanol and 1,2-hexanediol, preferably in an amount of 4 to 6 parts by weight.

In one embodiment, the emulsions may be synthetic or natural emulsifiers, for example, natural ester oils such as PEG-7 olive oil esters, preferably 1 to 2 parts by weight.

In one embodiment, the chelating agent may be EDTA, EGTA, ethylenediamine, oxine or o-phenanthroline as a metal ion blocking agent for reducing the chemical reaction by metal ions, and may be used in an amount of 0.5 to 1.5 parts by weight .

In one embodiment, the hyaluronic acid may be used in the form of sodium hyaluronate, preferably in an amount of 1 to 3 parts by weight.

In one embodiment, the active ingredient is selected from the group consisting of lavender oil, peppermint oil, tea tree oil, rosemary oil, orange oil, lemon grass oil, eucalyptus oil, chamomile oil, citronella oil, frankincense oil, And at least one natural oil selected from the group consisting of chrysanthemum oil. The natural oil is preferably contained in an amount of 0.01 to 0.5 parts by weight.

Hereinafter, the present invention will be described in more detail with reference to the following examples.

Method of manufacturing herbal extract

1: 1: 1: 1: 1: 1: 1.6, and then the herbal ingredients such as the herbicide, the herbicide, the herbaceous plant, Was heated at 2 atm and at 150 ° C for 2 hours, and then dried at 90 ° C for 3 hours. About 5 times as much water as the weight of the dried mixture was added and extracted with hot water at 150 캜 for 2 hours to prepare a herbal extract.

Manufacturing method of herbal composition

2.0 g of glycerin, 2.0 g of hyaluronic acid, 3.0 ml of ethanol, 2.0 ml of 1,2-hexanediol, 2.0 ml of glycoll, and 1.0 g of EDTA were mixed with 75 ml of the herbal extract prepared according to the method of Example 1 , 1.5 ml of PEG-7 olive oil ester, 30 g of carbomer and 3 g of triethanolamine was stirred for 2 hours. After the visible layer separation was removed, 2 drops of each of rosemary oil and peppermint oil were added, followed by stirring for 30 minutes.

Efficacy test of herbal composition

VAS measurements were used to test the efficacy of the herbal composition according to the present invention. A visual analog scale (VAS) is a test method to determine the degree of pain in a patient. It is a 10cm long line that records no pain at one end and the most severe pain imaginable at the end of the other. Patients fill this level with the pain they feel at the time of the measurement. Although this method can not compare one patient to another, it is a measurement that has the advantage of being able to pinpoint how the pain is changing for the same patient.

The detailed conditions for testing other efficacy are as follows.

1. Selection criteria for subjects

1) Target disease and indications: Chronic shoulder pain patients

2) Selection criteria of subjects

- adults over 20 years old and under 80 years old

- People who have had shoulder pain on one side for more than 3 months

- People who have not changed symptoms within the past one month

- A person who displays more than 40mm on a 100mm VAS with shoulder pain

- People who do not have severe pain in other parts of the body than shoulder pain

- The person who decided to voluntarily participate in this clinical trial and agreed in writing

3) Exclusion criteria for subjects

- Shoulder pain on both sides

- Shoulder pain resulting from injury of the trauma or spinal cord within the last 4 weeks

- Shoulder pain caused by inflammatory or tumorigenic

- Physical examination and diagnosis If the medical examination indicates that inflammatory arthritis such as infectious disease or autoimmune disease is suspected

- If there is a neurological disorder such as paralysis in the local sensation or systemic sensation

- A tattoo on the affected part, a wound that is difficult to apply gel

- Those who have plans for pregnancy, lactation and pregnancy

- Those who think that other clinical researchers are not suitable for participating in the study

2. Test method

1) Number of target subjects: 15 subjects in the experimental group and 15 subjects in the control group (Placebo)

2) First Visit (Visit 1)

- screening test after recruitment and participation agreement

: Demographic information, signs of vitality, physical examination, history of disease and surgery, confirmation of previous medication use, urine HCG pregnancy test (stick), VAS evaluation for fertile women

3) Second performance (Visit 2, concurrent with first performance)

- Pre-test baseline test

: After randomization, physical examination, vital signs, VAS, numeric rating scale (NRS), shoulder pain and disability index (SPADI), and Constant shoulder assessment scale

- How to use gel (Apply 1 morning and 2 times in the evening)

- Training for pain notes (VAS check before application of gel after morning wake up for 2 weeks)

3) Telephone consultation

: One week after the second visit, the phone confirms compliance, adverse reactions, pain notes and NRS measurements

4) Third Visit (Visit 3)

- Two weeks after the second performance (± 3 days), the adverse reactions and VAS, NRS, CSA, SPADI were evaluated

- The pain note was collected, and the composition of the present invention was given to the control group

- Perform blind test

3. Evaluation and Interpretation

The demographic data were analyzed by Student's t-test or chi-squre test by treatment group to confirm the validity of the randomization and subsequent analysis.

In order to show that the difference of 100 mm VAS between the 2nd visit (Visit 2) and the experimental group using the composition of the present invention was significantly superior to that of the control group, which was the first validity evaluation variable, (95.5% confidence interval for both sides) is larger than 0, which is a 97.5% confidence interval for one side. The confidence interval was obtained from Student's t-test.

For the other validation variables, Student's t-test or Wilcoxon's rank sum test was used for comparison between groups. SPADI and CSA were evaluated at baseline and at 2 weeks as secondary efficacy endpoints. Student's t-test or Wilcoxon's rank sum test was used to determine whether there was a difference between the experimental group and the control group using the values of the baseline and 2-week evaluation variables.

4. Clinical Test Results

1) Basic patient information

The VAS values of the patients before treatment were 73.13 ± 9.99 in the experimental group and 76.40 ± 8.45 in the control group (Placebo gel treatment group). In addition, there was no significant difference in the distributions of left and right shoulder pain and sex distribution. There was no significant difference in age, weight, and height between the two groups. This is shown in Table 1 below.

VAS value (mean + standard deviation) Experimental group Control group Shoulder pain VAS value 73.13 + - 9.99 76.40 + - 8.45 Pain (right / left) (8/7) (9/6) Sex (M / F) (1/14) (3/12) age 53.6 ± 12.33 52.00 ± 13.59 weight 55.53 7.85 63.53 + - 13.76 kidney 156.86 + - 7.03 162.60 ± 8.66

2) Depending on the date of treatment Experimental group  Control VAS Value variation

The VAS of shoulder pain was 73.13 ± 9.99 in the baseline group and 76.40 ± 8.45 in the control group, but the result after 15 days was similar to that before treatment in the control group and 50.47 ± 11.32 in the experimental group Respectively. This is shown in Table 2 and FIG.

VAS value of shoulder pain according to treatment date Days
VAS value (mean + standard deviation) Experimental group Control group 0 73.13 + - 9.99 76.40 + - 8.45 One 69.67 ± 10.76 76.40 +/- 10.85 2 67.67 ± 12.13 75.33 + - 11.32 3 66.67 ± 11.39 75.13 + - 11.48 4 63.93 + - 11.44 73.87 ± 13.68 5 63.40 ± 10.56 72.73 + - 14.78 6 64.13 + - 8.56 73.20 ± 15.16 7 62.20 + - 10.48 71.33 + - 15.66 8 60.27 + - 10.75 74.00 ± 16.61 9 57.93 + - 13.94 73.20 ± 16.51 10 57.73 + - 11.97 72.93 + - 16.83 11 56.93 + - 12.40 72.73 ± 17.81 12 54.53 + - 12.47 71.20 ± 18.02 13 51.47 + - 11.75 71.13 + - 20.07 14 50.87 ± 13.00 71.07 ± 20.47 15 50.47 + - 11.32 73.73 ± 19.24

3) Depending on the treatment Experimental group  Control VAS value  Variation

The mean VAS change was 1.07 ± 7.72 at day 1 and 5.33 ± 19.54 at day 14 in the control group, based on the VAS value of the shoulder pain measured by the patient in each day. appear. However, in the experimental group, it was found that the degree of pain decreased according to the number of treatments, which was 9.73 ± 7.56 at 5 days, 12.87 ± 10.98 at 16 days, 16.20 ± 11.19 at 11 days, and 22.67 ± 10.38 at 15 days.

As a result of comparing the two groups according to the treatment date, the VAS change was significantly higher in the experimental group from 8th to 15th day than the control group. That is, the degree of shoulder pain in the experimental group was significantly lowered from the eighth day than the control group.

The composition of the present invention showed a superior therapeutic effect on the eighth day than the control group by continuously reducing the pain, and the therapeutic effect was continuously increased until the 15th day.

In the control group, the degree of shoulder pain decreased by 7% at the 14th day, while in the experimental group, the degree of pain decreased continuously by the treatment, decreased by 18% at the 8th day, And 31%, respectively. The results are shown in Table 3 and FIG.

 Variation of VAS value of shoulder pain according to treatment date Days
Variation of VAS value (mean + standard deviation) Difference
P value
Experimental group Control group One 3.47 ± 3.04 0.00 ± 7.66 3.47 0.06 2 5.47 ± 5.67 1.07 + - 7.72 4.40 0.04 3 6.47 ± 6.02 1.27 ± 9.90 5.20 0.05 4 3.13 ± 3.38 1.27 + - 5.79 1.87 0.14 5 9.73 ± 7.56 3.67 ± 12.19 6.07 0.06 6 9.00 ± 6.30 3.20 ± 12.61 5.80 0.06 7 10.93 ± 9.15 5.07 ± 14.29 5.87 0.10 8 12.87 ± 10.98 2.40 ± 15.18 10.47 0.02 9 15.20 + - 8.64 3.20 ± 14.79 12.00 0.01 10 15.40 ± 8.58 3.47 ± 15.44 11.93 0.01 11 16.20 ± 11.19 3.67 ± 16.05 12.53 0.01 12 18.60 ± 10.62 5.20 ± 16.89 13.40 0.01 13 21.67 ± 9.01 5.27 ± 18.51 16.40 0.00 14 22.27 ± 10.26 5.33 ± 19.54 16.93 0.00 15 22.67 + - 10.38 2.67 ± 17.16 20.00 0.00

Changes in SPAD, CSA, and NRS due to treatment Experimental group Control group Difference P value SPADI 16.60 ± 11.00 -5.67 ± 15.10 22.27 0.00 CSA -6.13 + - 4.29 5.87 ± 7.09 -12.00 0.00  1 week NRS 1.53 + - 0.74 0.33 + 0.49 1.20 0.00  2 weeks NRS 2.47 ± 0.83 0.20 ± 1.26 2.27 0.00

According to the SPADI value, the change in pain before and after treatment for 2 weeks was 16.60 ± 11.00 in the experimental group and -5.67 ± 15.10 in the control group, which showed a significant improvement in the experimental group. The results of SPADI showed no significant improvement in the control group.

In addition, the change of the numerical rating scale (NRS) on pain was significantly higher than that of the control group (0.33 ± 0.49) at 1 week, 1.53 ± 0.74 in the experimental group, To 2.47 ± 0.83, which was significantly higher than that of the control group (0.20 ± 1.26).

However, the change of the CSA (Constant Shoulder Assessment) was 5.87 ± 7.09 in the control group after 2 weeks of treatment, but it was -6.13 ± 4.29 in the experimental group.

In other words, it was found that SPADI and NRS significantly improved shoulder pain and function in the experimental group compared to the control group. This is shown in Table 4 above.

As described above, the pain relieving herbal composition according to the present invention provides the effect of pain relief by being applied to muscles or joints.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention as defined in the following claims And changes may be made without departing from the spirit and scope of the invention. Many embodiments other than the above-described embodiments are within the scope of the claims of the present invention.

Claims (4)

8 to 12 parts by weight of white ginseng; 8 to 12 parts by weight of kerosene; 8 to 12 parts by weight of perfume; 8 to 12 parts by weight; 8 to 12 parts by weight of Seok Changpo; 8 to 12 parts by weight of ground paper; 8 to 12 parts by weight of acidophilus; 8 to 12 parts by weight of cordierite; 8 to 12 parts by weight of peppermint; And 14 to 18 parts by weight of a pear meat; and an aqueous or non-aqueous herbal extract of the mixture as an active ingredient. The herbicidal composition according to claim 1, wherein the herbal composition comprises at least one selected from the group consisting of thickening agent, purified water, moisturizing agent, alcohol solvent, emulsifier, chelating agent and hyaluronic acid. The composition according to claim 1, wherein the herbal composition comprises 45 to 75 parts by weight of herbal extract; From 30 to 35 parts by weight of an increasing amount; 6 to 10 parts by weight of purified water; 4 to 6 parts by weight of a moisturizer; 4 to 6 parts by weight of an alcohol solvent; 1 to 2 parts by weight of an emulsifier; 0.5 to 1.5 parts by weight of a chelating agent; And 1 to 3 parts by weight of hyaluronic acid. The composition of claim 1, wherein the at least one composition is selected from the group consisting of lavender oil, peppermint oil, tea tree oil, rosemary oil, orange oil, lemon grass oil, eucalyptus oil, chamomile oil, citronella oil, frankincense oil, Wherein the oil composition further comprises 0.01 to 0.5 parts by weight of at least one natural oil selected from the group consisting of palmarose oil and parchment oil.

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