CN113144123A

CN113144123A - Traditional Chinese medicine composition for eliminating rash and relieving itching of damaged sensitive muscles and application thereof

Info

Publication number: CN113144123A
Application number: CN202110516381.9A
Authority: CN
Inventors: 谢云波; 张楚东
Original assignee: Qingyuan Wangsha Biotechnology Co Ltd
Current assignee: Qingyuan Wangsha Biotechnology Co Ltd
Priority date: 2021-05-12
Filing date: 2021-05-12
Publication date: 2021-07-23

Abstract

The invention discloses a traditional Chinese medicine composition for eliminating herpes and relieving itching aiming at damaged sensitive muscles and application thereof. The traditional Chinese medicine composition for eliminating herpes and relieving itching is mainly prepared by extracting the following traditional Chinese medicinal materials in parts by weight: 20-30 parts of phellodendron, 20-30 parts of radix sophorae flavescentis, 20-30 parts of cynanchum paniculatum, 10-20 parts of fructus kochiae, 5-10 parts of cortex dictamni, 10-20 parts of radix stemonae, 5-10 parts of hawthorn, 10-20 parts of dark plum, 10-20 parts of angelica and 20-30 parts of euphorbia hirta. The raw materials in the rash-eliminating and itching-relieving formula are reasonable in dosage compatibility, and the tonifying and drug property-relaxing effects of the formula are enhanced by adopting a honey-fried method. The skin care lotion has a good nursing effect on discomfort feelings of redness, rash, dryness, stabbing pain, burning pain, pruritus and the like of damaged and sensitive skin, and can enable the skin to return to a healthy state after long-term use.

Description

Traditional Chinese medicine composition for eliminating rash and relieving itching of damaged sensitive muscles and application thereof

Technical Field

The invention relates to the field of cosmetics, and particularly relates to a traditional Chinese medicine composition for eliminating herpes and relieving itching for damaged sensitive muscles and application thereof.

Background

Along with the rapid development of domestic economy, the living standard of residents is improved, and meanwhile, people with sensitive skin are more and more caused by factors such as air pollution (mainly haze), overtime, living stress, anxiety, insufficient sun protection, excessive skin care, face-lifting, excessive color makeup, irritant food, electromagnetic radiation and the like. According to the world health organization survey, 40% -56% of asian women are sensitive muscles. According to the report of 'Chinese sensitive skin treatment expert consensus' in 2017, 36.1% of women in China are sensitive skins, which means that 1 sensitive muscle exists in every 3 persons.

Sensitive skin is a highly reactive, poorly tolerated skin condition that results from a variety of causes. Sensitive skin generally suffers from the following skin troubles: the skin is easy to be stimulated by the outside to be reddened, heated, itchy, stabbing pain and the like; red swelling and rash appear seriously; the irritation of uneven skin color is accompanied, and the inflammation fading is easy to leave marks or spots; damaged cuticle easily causes dry skin and desquamation; the skin has poor water retention capacity, and is tight and dry; many acnes of unknown origin appear suddenly and are not effective with any acne-removing product.

Sensitive skin will become progressively worse if it is not well-cared. Specifically, pruritus and desquamation at skin thin and tender parts such as face are generally taken as initial symptoms, and gradually develop into symptoms such as edema, pimple, desquamation and infiltration of ears, necks and even whole bodies, and the internal symptoms are that skin barrier function is damaged, nerve reaction is excessively enhanced, subcutaneous inflammatory reaction and other problems are mutually influenced and interwoven to form vicious circle.

Thus, the use of targeted cosmetics and conscious everyday skin care practices play an important role. In recent years, daily skin care has been recognized as an important approach to the treatment of damaged and sensitive skin.

The Chinese medicinal materials related to the invention are briefly introduced as follows:

the phellodendron bark is the bark of phellodendron bark of a deciduous arbor plant of Rutaceae without cork bark, and is bitter in taste and cold in nature. Enter kidney and bladder meridians. The functions are as follows: clearing heat, eliminating dampness, purging fire, removing toxic substances, and relieving deficiency heat. The main treatment is as follows: dysentery due to heat, diarrhea, diabetes, jaundice, flaccidity 36484m, nocturnal emission, stranguria with turbid urine, hemorrhoid, hematochezia, leucorrhea with red and white discharge, hectic fever due to yin-deficiency, conjunctival congestion, sore of mouth and tongue, and pyocutaneous disease and toxic swelling.

The radix sophorae flavescentis is the root of the leguminous perennial deciduous shrub plant radix sophorae flavescentis. Bitter taste and cold nature. Enter liver, kidney, large intestine and small intestine meridians. The functions are as follows: clearing away heat, eliminating dampness, killing parasites, and promoting urination. The main treatment is as follows: dysentery due to toxic heat and bloody stool, intestinal wind and bloody stool, jaundice, leucorrhea with red and white discharge, infantile pneumonia, malnutritional stagnation, acute tonsillitis, anal fistula, rectocele, skin pruritus, scabies, malignant sore, eczema and pruritus vulvae, scrofula, and scald.

The paniculate swallowwort root is the whole plant with roots of paniculate swallowwort root which is a plant of asclepiadaceae. Also named as ghost governor meridian (Ben Jing), Bixianzong (Ben Cao Tu Jing), and Shang Zhu (Standby raw herb for medicinal Property). Pungent flavor and warm nature. Enter liver and stomach meridians. The functions are as follows: relieving pain, relieving cough, inducing diuresis to alleviate edema, promoting blood circulation and removing toxic substances. The main treatment is as follows: stomachache, toothache, rheumatism pain, menstrual abdominal pain, chronic tracheitis, ascites, edema, dysentery, enteritis, traumatic injury, eczema, urticaria, and venomous snake bite.

The fructus kochiae provided by the invention is the fruit of the plant kochia scoparia of Chenopodiaceae. Sweet and bitter in flavor and cold in nature. Enter kidney and bladder meridians. The functions are as follows: promoting urination, clearing away damp-heat, and relieving itching. The main treatment is as follows: dysuria, gonorrhea, leukorrhagia, hernia, rubella, sore, scabies, tinea, and pudendal pruritus.

The cortex dictamni is root bark of a rutaceae herbaceous plant cortex dictamni (also called dictamnus alba and the like). Bitter, salty and cold in nature. Enter spleen and stomach meridians. The functions are as follows: clearing away heat and toxic materials, dispelling pathogenic wind, eliminating dampness, and relieving itching. The main treatment is as follows: wind-heat sore, scabies, tinea, prurigo, rheumatalgia, and jaundice.

The stemona root of the invention is the tuber root of stemona japonica of stemonaceae. Sweet and bitter in flavor and slightly warm in nature. Enter the lung meridian. The functions are as follows: moisten lung qi, relieve cough, kill parasites. The main treatment is as follows: cough due to wind-cold evil, pertussis, pulmonary tuberculosis, senile cough and asthma, ascariasis, enterobiasis, scabies, and eczema.

The hawthorn is the fruit of Crataegus cuneata of Rosaceae. Also known as Shanlixiang haw (Baiyichongfang). Sour and sweet in flavor, slightly warm in nature. Enter spleen, stomach and liver meridians. The functions are as follows: promoting digestion, dispelling blood stasis, and expelling tapeworm. The main treatment is as follows: meat stagnation, abdominal mass, phlegm and fluid retention, distention and fullness, acid regurgitation, dysentery, intestinal wind, lumbago, hernia, puerperal infantile occipital pain, lochiorrhea, and infantile indigestion.

The dark plum of the present invention is a smoked product processed from immature fruit of prunus mume (prunus mume) of the family rosaceae. Also known as Mei Shi (Ben Jing), etc. Sour in flavor and warm in nature. Enter liver, spleen, lung and large intestine meridians. The functions are as follows: astringe lung, promote fluid production, astringe intestine, and expel ascarid. The main treatment is as follows: chronic cough, asthenic fever, polydipsia, chronic malaria, chronic diarrhea, dysentery, hematochezia, hematuria, metrorrhagia, abdominal pain due to ascariasis, emesis, ancylostomiasis, psoriasis, pterygium.

The angelica is the root of angelica in the family of Umbelliferae. It is also called as gan Gui (Ben Jing). Sweet and pungent in flavor and warm in nature. Enter liver, heart and spleen meridians. The functions are as follows: nourishing blood, regulating menstruation, relieving pain, moistening dryness, and smoothing intestine. The main treatment is as follows: menoxenia, amenorrhea, abdominal pain, abdominal mass, metrorrhagia; headache, vertigo, flaccidity arthralgia due to blood deficiency; intestinal dryness, difficulty in defecation, and severe dysentery; carbuncle, deep-rooted carbuncle, pyocutaneous disease, traumatic injury.

The euphorbia hirta of the invention is a dried whole plant of euphorbiaceae plant euphorbia hirta. Pungent and sour in flavor and cool in nature. It enters lung, bladder and large intestine meridians. The functions are as follows: clearing away heat and toxic material, removing dampness by diuresis, relieving itching and promoting lactation. The main treatment is as follows: pulmonary abscess, acute mastitis, furuncle, toxic swelling, ulcerative gingivitis, dysentery, diarrhea, heat stranguria, hematuria, eczema, tinea pedis, skin pruritus, and puerperal hypogalactia.

The forsythia suspense is a dried fruit of forsythia suspense which belongs to the family of the Oleaceae. Bitter taste and cool nature. Enter heart, lung, liver and gallbladder meridians. The functions are as follows: clearing away heat and toxic material, dissipating mass and relieving swelling. The main treatment is as follows: warm heat, erysipelas, macula, superficial infection and pyogenic infection, scrofula, wind-heat type common cold, early warm heat, high fever, polydipsia, coma, macula, heat stranguria and anuresis.

The honeysuckle flower of the invention is a dried flower bud or a flower with early blossoming of a honeysuckle plant of Caprifoliaceae. Sweet in flavor and cold in nature. Enters lung, heart, stomach and large intestine meridians. The functions are as follows: clearing away heat and toxic material. The main treatment is as follows: epidemic febrile disease, fever, wind-heat type common cold, carbuncle, furuncle, scrofula, pharyngitis, erysipelas, heat toxin, bloody dysentery, and anal fistula.

The dandelion is the whole herb with root of the perennial herb dandelion of the compositae. Bitter and sweet in taste and cold in nature. Enter liver and stomach meridians. The functions are as follows: clearing away heat and toxic material, promoting urination, and dispersing pathogen accumulation. The main treatment is as follows: acute mastitis, lymphadenitis, scrofula, furunculosis, acute conjunctivitis, common cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.

The frankincense is gum resin of boswellia carterii of the family olive. Pungent and bitter with warm nature. Enter heart, liver and spleen meridians. The functions are as follows: promoting blood circulation, relieving pain, eliminating swelling, and promoting granulation. The main treatment is as follows: stagnation of qi and blood, pain in heart and abdomen, carbuncle, sore, toxic swelling, traumatic injury, dysmenorrhea, and puerperal blood stasis and pain.

The myrrh is gum resin of myrrh tree of the family of olive. Bitter taste and mild nature. Enter liver meridian. The functions are as follows: disperse blood and remove blood stasis, relieve swelling and relieve pain. The main treatment is as follows: traumatic injury, incised wound, bone and muscle, pain of heart and abdomen, abdominal mass, amenorrhea, carbuncle, swelling and pain, anal fistula, and eye disorders.

The gallnut is gall formed by the euglena angustifolia or the egyporus plocae which are insects of the family Aphididae on trees such as rhus chinensis, populus diversifolia or populus rubra which are hosts of the gallnut. Also named as Meretrix Linnaeus (Kaibao Ben Cao), etc. Sour, salty, astringent and cold in nature. Enters lung, stomach, kidney and large intestine meridians. The functions are as follows: astringe lung to reduce pathogenic fire, astringe intestine to stop diarrhea, arrest spontaneous emission, arrest sweating, stop bleeding, and remove toxic substance. The main treatment is as follows: lung deficiency, chronic cough, chronic dysentery, chronic diarrhea, rectocele, spontaneous perspiration, night sweat, spermatorrhea, hematochezia, epistaxis, metrorrhagia, traumatic hemorrhage, toxic swelling, skin ulcer, furuncle, and inverted eyelash roll.

Disclosure of Invention

In view of the above, the invention provides a traditional Chinese medicine composition for eliminating rash and relieving itching for damaged and sensitive skin.

In order to achieve the above object, the present invention provides the following technical solutions:

a traditional Chinese medicine composition for eliminating rash and relieving itching is mainly prepared by extracting the following traditional Chinese medicines in parts by weight: 20-30 parts of phellodendron, 20-30 parts of radix sophorae flavescentis, 20-30 parts of cynanchum paniculatum, 10-20 parts of fructus kochiae, 5-10 parts of cortex dictamni, 10-20 parts of radix stemonae, 5-10 parts of hawthorn, 10-20 parts of dark plum, 10-20 parts of angelica and 20-30 parts of euphorbia hirta.

In some embodiments of the invention, the traditional Chinese medicine composition for eliminating rash and relieving itching is mainly prepared by extracting the following traditional Chinese medicinal materials in parts by weight: 25 parts of phellodendron, 25 parts of sophora flavescens, 25 parts of cynanchum paniculatum, 15 parts of fructus kochiae, 8 parts of cortex dictamni, 15 parts of radix stemonae, 8 parts of hawthorn, 15 parts of dark plum, 15 parts of angelica and 25 parts of euphorbia hirta.

In some embodiments of the present invention, for those with severe heat toxicity, the preparation of the rash-eliminating and itching-relieving traditional Chinese medicine composition further comprises the following raw materials: 10 parts of fructus forsythiae, 15 parts of honeysuckle and 20 parts of dandelion.

In some embodiments of the present invention, for patients with dark rash and long-lasting skin damage, the preparation of the traditional Chinese medicine composition for eliminating rash and relieving itching further comprises the following raw materials: 15 parts of frankincense, 5 parts of myrrh and 10 parts of gallnut.

The traditional Chinese medicine composition for eliminating rash and relieving itching is mainly used for damaged and sensitive skin, can be used alone, and can also be used as an active additive to be applied to cosmetics.

The embodiment of the invention also discloses a preparation method of the traditional Chinese medicine composition for eliminating herpes and relieving itching, which comprises the following steps: (1) weighing the raw materials according to the formula, chopping, adding honey with the total weight of 0.2-0.3 times of the raw materials, and moistening; roasting with slow fire to dry to obtain honey-roasted medicinal materials; then crushing to obtain medicinal powder; (2) adding water with the total weight 6-10 times of the medicinal powder, and soaking for 1-2 hr; (3) decocting with strong fire for 10-30 min, and filtering to obtain decoction; (4) centrifuging the decoction, collecting supernatant, aging at 1-5 deg.C for 1-2 days, and centrifuging again to obtain supernatant.

The technical scheme provided by the embodiment of the invention has the following beneficial effects:

(1) the invention provides a rash-eliminating and itching-relieving formula which mainly comprises traditional Chinese medicine raw materials such as golden cypress, radix sophorae flavescentis, paniculate swallowwort root, fructus kochiae, cortex dictamni, radix stemonae, hawthorn, dark plum, angelica sinensis and garden euphorbia herb, wherein the golden cypress and the radix sophorae flavescentis are used as monarch drugs to discharge fire and detoxify, and promote diuresis and dissipate stagnation; the paniculate swallowwort root, the broom cypress fruit, the cortex dictamni and the radix stemonae are taken as ministers, and the Chinese medicinal composition has the effects of dispelling wind, relieving itching, inducing diuresis and relieving swelling; the hawthorn, the dark plum, the angelica and the garden euphorbia herb are used as adjuvant and guiding drugs to promote blood circulation and promote tissue regeneration, and strengthen the body resistance and consolidate the constitution. Fructus forsythiae, herba Taraxaci, and flos Lonicerae may be added for patients with serious toxic heat. Olibanum, Myrrha, and Galla chinensis can be added for treating dark rash and long-lasting skin injury.

(2) The raw materials in the rash-eliminating and itching-relieving formula are reasonable in dosage compatibility, and the tonifying and drug property-relaxing effects of the formula are enhanced by adopting a honey-fried method. Tests prove that the skin care lotion has a good nursing effect on discomfort feelings of redness, rash, dryness, stabbing pain, burning pain, pruritus and the like of damaged and sensitive skin, and can enable the skin to return to a healthy state after long-term use.

Detailed Description

The invention discloses a traditional Chinese medicine composition for eliminating herpes and relieving itching aiming at damaged sensitive muscles and application thereof. Those skilled in the art can modify the process parameters appropriately to achieve the desired results with reference to the disclosure herein. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the methods and applications of this invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as appropriate variations and combinations, may be made to implement and use the techniques of this invention without departing from the spirit and scope of the invention.

The raw materials and reagents used in the traditional Chinese medicine composition for eliminating herpes and relieving itching provided by the invention can be purchased from the market.

The invention is further illustrated by the following examples:

example 1

A traditional Chinese medicine composition for eliminating herpes and relieving itching is prepared by the following method:

(1) weighing the following traditional Chinese medicinal materials in parts by weight: 20 parts of phellodendron, 30 parts of sophora flavescens, 20 parts of cynanchum paniculatum, 20 parts of fructus kochiae, 5 parts of cortex dictamni, 20 parts of radix stemonae, 5 parts of hawthorn, 20 parts of dark plum, 10 parts of angelica and 30 parts of euphorbia hirta;

(2) cutting the Chinese medicinal materials, adding honey with the total weight 0.2 times of the Chinese medicinal materials, and moistening; roasting with slow fire to dry to obtain honey-roasted medicinal materials; then crushing to obtain medicinal powder;

(3) adding water with the total weight 10 times of the medicinal powder to soak for 1 hour;

(4) decocting with strong fire for 30 min, and filtering to obtain decoction;

(5) centrifuging the decoction, collecting supernatant, aging at 1 deg.C for 2 days, and centrifuging again to obtain supernatant.

Example 2

(1) weighing the following traditional Chinese medicinal materials in parts by weight: 30 parts of phellodendron, 20 parts of sophora flavescens, 30 parts of cynanchum paniculatum, 10 parts of fructus kochiae, 10 parts of cortex dictamni, 10 parts of radix stemonae, 10 parts of hawthorn, 10 parts of dark plum, 20 parts of angelica and 20 parts of euphorbia hirta;

(2) cutting the Chinese medicinal materials, adding honey with the total weight 0.3 times of the Chinese medicinal materials, and moistening; roasting with slow fire to dry to obtain honey-roasted medicinal materials; then crushing to obtain medicinal powder;

(3) adding water with the total weight 6 times of the medicinal powder to soak for 2 hours;

(4) decocting with strong fire for 10 min, and filtering to obtain decoction;

(5) centrifuging the decoction, collecting supernatant, aging at 5 deg.C for 1 day, and centrifuging again to obtain supernatant.

Example 3

(1) weighing the following traditional Chinese medicinal materials in parts by weight: 25 parts of phellodendron, 25 parts of sophora flavescens, 25 parts of cynanchum paniculatum, 15 parts of fructus kochiae, 8 parts of cortex dictamni, 15 parts of radix stemonae, 8 parts of hawthorn, 15 parts of dark plum, 15 parts of angelica and 25 parts of euphorbia hirta;

(2) cutting the Chinese medicinal materials, adding honey with the total weight of 0.25 times of the Chinese medicinal materials, and moistening; roasting with slow fire to dry to obtain honey-roasted medicinal materials; then crushing to obtain medicinal powder;

(3) adding water with the total weight 8 times of the medicinal powder, and soaking for 1.5 hours;

(4) decocting with strong fire for 20 min, and filtering to obtain decoction;

(5) centrifuging the decoction, collecting supernatant, aging at 3 deg.C for 1.5 days, and centrifuging again to obtain supernatant.

Example 4

(1) weighing the following traditional Chinese medicinal materials in parts by weight: 25 parts of phellodendron, 25 parts of sophora flavescens, 25 parts of cynanchum paniculatum, 15 parts of fructus kochiae, 8 parts of cortex dictamni, 15 parts of radix stemonae, 8 parts of hawthorn, 15 parts of dark plum, 15 parts of angelica, 25 parts of euphorbia hirta, 10 parts of fructus forsythiae, 15 parts of honeysuckle and 20 parts of dandelion;

(4) decocting with strong fire for 20 min, and filtering to obtain decoction;

Example 5

(1) weighing the following traditional Chinese medicinal materials in parts by weight: 25 parts of phellodendron, 25 parts of sophora flavescens, 25 parts of cynanchum paniculatum, 15 parts of fructus kochiae, 8 parts of cortex dictamni, 15 parts of radix stemonae, 8 parts of hawthorn, 15 parts of dark plum, 15 parts of angelica, 25 parts of euphorbia hirta, 15 parts of frankincense, 5 parts of myrrh and 10 parts of gallnut;

(4) decocting with strong fire for 20 min, and filtering to obtain decoction;

Example 6

A basic moisturizer comprises the following components in percentage by mass: 1% of C20-22 alcohol phosphate, 1% of C20-22 alcohol, 3% of cetearyl alcohol, 0.5% of glyceryl stearate, 0.5% of PEG-100 stearate, 5% of mineral oil, 5% of petrolatum, 3% of cyclopentadimethylsiloxane, 1% of polydimethylsiloxane crosspolymer, 1% of hydrogenated polydecene, 2% of polydimethylsiloxane, 3% of caprylic/capric triglyceride, 5% of glycerol, 3% of propylene glycol, 3% of butylene glycol, 0.2% of methylparaben, 0.05% of caprylhydroxamic acid, 1, 2-hexanediol, 0.1% of xanthan gum, 60.5% of polyacrylate crosspolymer and the balance of water.

The basic moisturizer is prepared by the following process: weighing water, adding into emulsifying pot, adding dispersed phase A (glycerol, propylene glycol, butanediol, methyl hydroxybenzoate, caprylyl hydroxamic acid, 1, 2-hexanediol, sodium hyaluronate, xanthan gum, and polyacrylate cross-linked polymer-6) under homogenizing condition, stirring, and heating to 80-85 deg.C; putting the phase B (C20-22 alcohol phosphate, C20-22 alcohol, cetostearyl alcohol, glyceryl stearate, PEG-100 stearate, mineral oil, petrolatum, cyclopentadimethylsiloxane, polydimethylsiloxane cross-linked polymer, hydrogenated polydecene, polydimethylsiloxane and caprylic/capric triglyceride) into an oil pan, heating to 70-75 ℃, and completely dissolving; pumping the phase B into an emulsifying pot, homogenizing for 2-3 minutes under vacuum, and preserving heat for 20 minutes under vacuum; slowly cooling to 48 ℃, filtering with 200-mesh filter cloth and discharging.

Effect example 1

The traditional Chinese medicine composition for eliminating the rash and relieving the itching is applied to cosmetics, and trial evaluation is carried out on sensitive skin patients so as to investigate the effect of the composition for eliminating the rash and relieving the itching.

The test samples of the present invention are as follows:

rash-eliminating itching-relieving moisturizer No. 1: 5 parts of the traditional Chinese medicine composition for eliminating herpes and relieving itching, which is prepared in the example 3, and 95 parts of the basic moisturizer, which is prepared in the example 6, are mixed, heated to 60 ℃, and then slowly stirred to room temperature.

Rash-eliminating itching-relieving moisturizer No. 2: taking 5 parts of the rash-eliminating and itching-relieving traditional Chinese medicine composition and 95 parts of the basic moisturizer prepared in the example 6, mixing, heating to 60 ℃, and slowly stirring to room temperature; the traditional Chinese medicine composition for eliminating herpes and relieving itching is prepared by the following method: (1) weighing the following traditional Chinese medicinal materials in parts by weight: 25 parts of phellodendron, 25 parts of sophora flavescens, 25 parts of cynanchum paniculatum, 15 parts of fructus kochiae, 8 parts of cortex dictamni, 15 parts of radix stemonae, 8 parts of hawthorn, 15 parts of dark plum, 15 parts of angelica and 25 parts of euphorbia hirta; (2) cutting the Chinese medicinal materials, and pulverizing to obtain medicinal powder; (3) adding water with the total weight 8 times of the medicinal powder, and soaking for 1.5 hours; (4) decocting with strong fire for 20 min, and filtering to obtain decoction; (5) centrifuging the decoction, collecting supernatant, aging at 3 deg.C for 1.5 days, and centrifuging again to obtain supernatant.

The diagnostic criteria for sensitive skin adopted by the invention are as follows:

reference is made to the sensitive skin diagnosis standard in 2016 university of Hunan Chinese medicine (clinical study on sensitive skin treatment by combination of Cuiyao, Jinshen beauty skin cream and hyaluronic acid repairing biomembrane [ D ]. university of Hunan Chinese medicine, 2016 ]), specifically as follows:

1) the face has discomfort such as skin redness, rash, dryness, stabbing pain, burning pain, itching, etc., and the lactic acid stimulation test scores more than 2 points (moderate stabbing pain). The lactic acid stimulation test scoring method comprises the following steps: dripping 50 μ L of 5% lactic acid on two layers of filter paper with diameter of 0.5cm, placing in nasolabial sulcus of subject, inquiring subject for stabbing pain at 0, 2.5, 5 and 8min, and observing skin reaction of subject, and scoring according to 4-point method: 0 for no stabbing pain, 1 for mild stabbing pain, 2 for moderate stabbing pain, and 3 for severe stabbing pain;

2) the skin is susceptible to external irritation to aggravate the allergic condition;

3) the attack is repeated, and the attack is more than 3 per year.

Inclusion criteria for volunteers in the present invention were:

1) meets the above diagnostic criteria;

2) the age is 18-65 years old;

3) no serious damage to liver and kidney function, cardiovascular and cerebrovascular diseases, serious systemic diseases of blood system, visceral tumor history and mental disease history;

4) history of using no antiallergic drugs and corticosteroid drugs in the half-month before treatment;

5) informed consent was voluntarily participated in the study, and the informed consent was signed on time for medication and further consultation.

The exclusion criteria for volunteers in the present invention were:

1) eliminating other diseases such as facial lupus erythematosus, lichen planus, neurodermatitis, chronic actinic dermatitis, erysipelas, etc.;

2) patients under the age of less than 18 or more than 65 years of age, in lactation, pregnancy and pregnancy preparation;

3) has serious damage to liver and kidney function, cardiovascular and cerebrovascular diseases, serious systemic diseases of blood system, visceral tumor history, and mental disease history;

4) the antiallergic drugs and the corticosteroid drugs are used in nearly half a month;

5) patients with allergy history of certain component of experimental medicine;

6) they were not willing to participate in this study and did not meet the inclusion criteria.

The volunteer sources and groups of the invention are as follows:

125 patients with impaired sensitive skin were treated according to the above criteria at the cooperative salon in 2019, month 3 to 2021, month 1. The treatment group and two control groups (control I group and control II group) were divided according to different treatment methods. The treatment group adopts No. 1 treatment of the rash-eliminating and itching-relieving moisturizer of the invention, and comprises 46 cases, wherein 7 cases of men and 39 cases of women have the average age (32.12 +/-8.13) years, the average course of disease (2.31 +/-1.26) years and the average lactic acid stimulation test score (2.39 +/-0.23). The control group I was treated with the rash-eliminating and itching-relieving moisturizer No. 2 of the present invention for 37 total cases, of which 3 male cases and 34 female cases, the mean age (30.51 + -7.81) year, the mean course (1.96 + -2.04) year, and the mean lactic acid stimulation score (2.44 + -0.37) score. The control group II was treated with the desonide cream for 42 cases, 9 men and 33 women, mean age (33.52 + -12.12) years, mean course (2.17 + -2.18) years, mean lactate stimulation score (2.41 + -0.19). The three groups are compared by sex, age, disease course and average lactic acid stimulation test score, and the difference has no statistical significance (P is more than 0.05) and is comparable.

The main testing equipment of the invention is as follows:

MPA skin tester of CK company in Germany, simultaneously connect a plurality of probes, the connected probes include: corneometer CM825 (moisture test probe), Tewameter TM300 (moisture loss test probe), and Temperature & rel.

The test method of the invention comprises the following steps:

applying appropriate amount of product (0.5-1g) on face, and gently beating for absorption, 1 time in the morning and evening, and continuously using for 12 weeks. Clinical symptoms, percutaneous water loss (TEWL) and skin stratum corneum water content of sensitive skin volunteers were examined before and after treatment. Follow-up visits were conducted 4 weeks and 8 weeks after the end of the experiment, and the conditions of each group of patients were collected by telephone, double-visit, etc., the follow-up patients were patients whose clinical efficacy improvement index was completely improved, and the patients were considered to have relapsed if the follow-up score exceeded the post-treatment score.

All data collected were analyzed using SPSS21.0 analysis software. The measured data is first tested in the normality test and the homogeneity of variance test to meet the requirement, P>0.05, analysis of variance is adopted; when not satisfying, P<0.05, adopting nonparametric detection. The counting data being represented by frequency numbers, X²And (6) checking. The comparison between the grade data is checked by a rank sum. Taking alpha as 0.05, P>0.05, the difference comparison has no statistical significance; p<0.05, the difference comparison has statistical significance; p<0.01, the difference comparison has significant statistical significance.

Symptom efficacy improvement assessment:

the volunteers were observed for skin symptoms including redness, rash, dryness, stinging, burning, itching, discomfort and recorded. Wherein the skin has no scales, no dry feeling, smoothness, no erythema and pimple, and the subjective symptom-free score of the volunteer is 0; the skin is slightly dry, scales are few, the skin is slightly rough, erythema pimples do not exist, volunteers feel obvious tightness and slight burning sensation, but the feeling of no pruritus is marked as 1 point; the skin is dry, scales are more, a small amount of erythema and pimples are generated, and volunteers feel obvious tightness, burning sensation and slight itching feeling and are marked as 2 points; the skin was dry, numerous scales, obvious erythema and papules, and the subjective symptoms of the volunteers were scored as 3 points.

The improvement of the curative effect is calculated by a nimodipine method, the improvement index is (pre-treatment score-post-treatment score)/pre-treatment score is 100%, and the improvement index is divided into 4 grades of complete improvement, obvious improvement, improvement and ineffectiveness according to the curative effect index. Complete improvement (improvement index > 90%), significant improvement (improvement index 60% -89%), improvement (improvement index 20% -59%), no effect (improvement index < 20%).

Total effective rate (complete improvement case number + obvious improvement case number + improvement case number)/total treatment case number 100%

And (3) test results:

(1) examination of improvement in therapeutic Effect of symptoms

The specific improvement of the therapeutic effect after 12 weeks of treatment in the treatment group, control group I and control group II is shown in the following tables 1-3.

TABLE 1 evaluation of the improvement of the curative effects of the three groups of symptoms before and after treatment

Group of	Number of examples	Is totally improved	Obviously improve	Improvements in or relating to	Invalidation	Total effective rate
							Treatment group	46	9	26	9	2	95.65％
Control group I	37	5	15	12	5	86.49％
							Control group II	42	4	16	15	7	83.33％

Comparing the three groups of curative effects, wherein the curative effects are grade data, and the curative effects of the treatment group and the control group I are compared by adopting rank sum test, wherein Z is-1.983, P is 0.047(P is less than 0.05), and the comparison of the two groups has statistical significance; the curative effect of the treatment group is compared with that of the control group II, Z is-2.795, P is 0.005(P is less than 0.01), and the comparison of the two groups has significant statistical significance; the control I group and the control II group have the curative effect comparison, Z is-0.670, P is 0.503(P is more than 0.05), and the comparison has no statistical significance. As shown in Table 1, the total effective rate of the treatment group is higher than that of the other two groups, and the treatment group has statistical significance compared with the two control groups, and the curative effect of the treatment group is better than that of the control group I and the control group II.

TABLE 2 comparison of mean lactic acid stimulation test scores before and after three groups of treatments

Group of	Before treatment	After treatment
			Treatment group	2.39±0.23	0.72±0.51**
Control group I	2.44±0.37	0.98±0.68**
			Control group II	2.41±0.19	1.20±0.43**

Note: p < 0.05, P < 0.01, compared to the group before treatment.

As can be seen from Table 2, the mean post-treatment lactate stimulation test scores of the three groups were significantly reduced compared to pre-treatment, and the differences were statistically significant (P < 0.01), but the differences were not statistically significant (P > 0.05) compared to the groups. The traditional Chinese medicine composition for eliminating herpes and relieving itching disclosed by the invention has a good repairing effect on sensitive muscles.

TABLE 3 comparison of relapse rates in three groups

Group of	Complete improvement/example	4 weeks/example after treatment	8 weeks/example after treatment
				Treatment group	9	0	1
Control group I	5	0	2
				Control group II	4	0	2

As can be seen from Table 3, there were recurrence cases in all three groups at 8 weeks after treatment, but the recurrence rate was relatively low in the treated group compared to the control group, showing a better anti-recurrence effect, and enabling the skin to return to a healthy state.

(2) Investigation of skin Barrier improvement

The improvement in skin barrier after 12 weeks of treatment in the treatment group, control I group and control II group is shown in table 4 below. The skin barrier can effectively prevent the invasion of external harmful factors and the loss of nutrient substances in the body, and the damage of the skin barrier function is an important reason of skin sensitivity. Because of the weak skin penetration capacity of the stratum corneum, irritants are more easily introduced to cause inflammatory reactions in the skin. Indexes such as percutaneous water loss (TEWL) and the water content of stratum corneum of the skin are all related to the skin barrier (see: Zhao. TEWL is applied to research for evaluating the skin barrier function [ J ]. Guangdong chemical industry, 2014, 41 (14): 133-.

TABLE 4 improvement of skin barrier efficacy before and after three groups of treatments

Note: p < 0.05, P < 0.01, compared to the group before treatment.

As can be seen from Table 4, the skin percutaneous water loss and the stratum corneum water content were significantly improved after the three groups of treatments compared with those before the treatment, and the differences were statistically significant (P < 0.01), but the differences were not statistically significant (P > 0.05) compared with the groups. The traditional Chinese medicine composition for eliminating rash and relieving itching has a good function of repairing skin barriers.

Effect example 2

In the application practice of the traditional Chinese medicine composition for eliminating rash and relieving itching, we also find that the skin damage of partial injured sensitive muscle volunteers is very serious, and can further optimize and adjust the traditional Chinese medicine composition for eliminating rash and relieving itching according to the symptom characteristics, such as: for patients with serious toxic heat, fructus forsythiae, herba Taraxaci, and flos Lonicerae can be added. For patients with dark rash and long-term skin damage and difficult healing, Olibanum, Myrrha, and Galla chinensis can be added.

The test samples of the present invention are as follows:

rash-eliminating itching-relieving moisturizer No. 2: 5 parts of the traditional Chinese medicine composition for eliminating herpes and relieving itching, which is prepared in the example 4, and 95 parts of the basic moisturizer, which is prepared in the example 6, are mixed, heated to 60 ℃, and then slowly stirred to room temperature.

Rash-eliminating itching-relieving moisturizer No. 3: 5 parts of the rash-eliminating and itching-relieving traditional Chinese medicine composition prepared in the example 5 and 95 parts of the basic moisturizer prepared in the example 6 are mixed, heated to 60 ℃, and then slowly stirred to room temperature.

The effect example 2 examines the treatment effect of the traditional Chinese medicine composition for eliminating rash and relieving itching on patients with serious heat toxin, dark rash and long-term skin damage and difficult healing. In this example, 64 injured sensitive skin volunteers were randomized into two groups of 32 individuals.

The test result shows that after 12 weeks of treatment, the total effective rate of the treatment group No. 2 of the rash-eliminating and itching-relieving moisturizer is 78.52%, the average lactic acid stimulation test score before treatment (2.64 +/-0.12) is divided, and the average lactic acid stimulation test score after treatment (1.30 +/-0.48) is divided. The total effective rate of the treatment group of the rash-eliminating and itching-relieving moisturizer No. 3 is 78.52%, the average lactic acid stimulation test score before treatment (2.64 +/-0.12) is divided, and the average lactic acid stimulation test score after treatment (1.30 +/-0.48) is divided.

Therefore, after the traditional Chinese medicine composition for eliminating rash and relieving itching is optimized and adjusted according to the symptom characteristics, the traditional Chinese medicine composition disclosed by the embodiment of the invention shows good treatment effects on patients with serious heat toxicity or patients with dark rash and long-lasting skin damage.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for eliminating herpes and relieving itching is characterized by being mainly prepared by extracting the following traditional Chinese medicinal materials in parts by weight: 20-30 parts of phellodendron, 20-30 parts of radix sophorae flavescentis, 20-30 parts of cynanchum paniculatum, 10-20 parts of fructus kochiae, 5-10 parts of cortex dictamni, 10-20 parts of radix stemonae, 5-10 parts of hawthorn, 10-20 parts of dark plum, 10-20 parts of angelica and 20-30 parts of euphorbia hirta.

2. The traditional Chinese medicine composition for eliminating rash and relieving itching as claimed in claim 1, which is mainly prepared by extracting the following traditional Chinese medicinal materials in parts by weight: 25 parts of phellodendron, 25 parts of sophora flavescens, 25 parts of cynanchum paniculatum, 15 parts of fructus kochiae, 8 parts of cortex dictamni, 15 parts of radix stemonae, 8 parts of hawthorn, 15 parts of dark plum, 15 parts of angelica and 25 parts of euphorbia hirta.

3. The traditional Chinese medicine composition for eliminating rash and relieving itching as claimed in claim 1, wherein the preparation of the traditional Chinese medicine composition for eliminating rash and relieving itching further comprises the following raw materials: 10 parts of fructus forsythiae, 15 parts of honeysuckle and 20 parts of dandelion.

4. The traditional Chinese medicine composition for eliminating rash and relieving itching as claimed in claim 1, wherein the preparation of the traditional Chinese medicine composition for eliminating rash and relieving itching further comprises the following raw materials: 15 parts of frankincense, 5 parts of myrrh and 10 parts of gallnut.

5. A rash and itch relieving traditional Chinese medicine composition according to any one of claims 1-4, characterized in that it is prepared by the steps of: (1) weighing the raw materials according to the formula, chopping, adding honey with the total weight of 0.2-0.3 times of the raw materials, and moistening; roasting with slow fire to dry to obtain honey-roasted medicinal materials; then crushing to obtain medicinal powder; (2) adding water with the total weight 6-10 times of the medicinal powder, and soaking for 1-2 hr; (3) decocting with strong fire for 10-30 min, and filtering to obtain decoction; (4) centrifuging the decoction, collecting supernatant, aging at 1-5 deg.C for 1-2 days, and centrifuging again to obtain supernatant.

6. Use of the Chinese medicinal composition for eliminating rash and relieving itching as claimed in any one of claims 1 to 4 in the preparation of cosmetics.