CN102274252A - Stauntonvine external applied preparation for treating rheumatoid diseases and preparation method thereof - Google Patents
Stauntonvine external applied preparation for treating rheumatoid diseases and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an external applied preparation for treating rheumatoid diseases, in particular to a stauntonvine external applied preparation for treating rheumatoid diseases. The stauntonvine external applied preparation provided by the invention is prepared from the following raw materials in part by weight: 10 to 100 parts of stauntonvine, and raw materials including eucommia bark, angelica dahurica, ligusticum wallichii, cortex acanthopanacis, clove and the like. The Chinese medicinal materials among the raw materials are washed and used to prepare external applied formulations for treating rheumatoid diseases such as patch and oil. The preparation has a treatment characteristic of external application, has little toxic and side effect, is convent for use, and has an auxiliary treatment effect on rheumatic arthritis, chronic infectious arthritis, diseases in sciatic nerve, sore muscle and the like and has effects of relaxing tendons and activating collaterals.
Description
Technical field
The present invention relates to the rheumatoid medicine of a kind of treatment, the rheumatoid Caulis et folium stauntoniae external preparation of especially a kind of treatment the invention still further relates to the preparation method of this external preparation.
Background technology
Rheumatoid disease is a kind of disease of stubbornness, heals than refractory.Treating this sick Chinese medicine, to adopt decoction oral mostly be main, as Hu Ximing chief editor's Chinese traditional Chinese medical science secret recipe complete works.Orally-administered decoction uses inconvenient, and Chinese medicine for oral administration is also bigger to the side effect of human body, and reactions such as inappetence, limbs fatigue appear in part patient.
Caulis et folium stauntoniae is a dicotyledon medicine Lardizabalaceae plant, and the Latin formal name used at school is Stauntonia chinensis Decne, is a kind of conventional Chinese medicine, motherland's medical science is put down in writing its sweet in the mouth, flat, and GUIXIN, kidney two warps have relaxing muscles and tendons and activating QI and blood in the collateral, to sciatica, muscular soreness has the auxiliary treatment effect.There is the scholar that the chemical constituent of Caulis et folium stauntoniae has been carried out than system, deep research in recent years, find to contain abundant saponin in the Caulis et folium stauntoniae, mainly comprise nor-Pentacyclic triterpene saponins compounds and lignanoid's glycosides compound, in addition, also contain flavonoid glycoside compound, phenolic constituent, saccharide compound, multivitamin and several mineral materials etc.Simple acupoint injection therapy stauntonvine injection treatment rheumatoid arthritis is arranged at present, evident in efficacy, but Caulis et folium stauntoniae uses separately and makes the couplings of external preparation or Caulis et folium stauntoniae and other treatment rheumatoid disease commonly used Chinese medicine and make external preparation treatment rheumatoid disease and do not have relevant report.
Summary of the invention
The object of the present invention is to provide the rheumatoid Caulis et folium stauntoniae external preparation of a kind of treatment, the invention still further relates to the preparation method of this external preparation.
Outstanding contributions of the present invention are the rheumatoid conventional Chinese medicine coupling of external preparation or Caulis et folium stauntoniae and other treatment to be made in the independent use of Caulis et folium stauntoniae make external use plaster, opened up the application of the new dosage form of Caulis et folium stauntoniae, clinical effectiveness shows that also Caulis et folium stauntoniae has certain curative effect at the external preparation aspect the treatment rheumatoid disease.
Technical scheme of the present invention is:
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is made: Caulis et folium stauntoniae 10-50 part.
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is made: Caulis et folium stauntoniae 10-50 part, Cortex Eucommiae 1-30 part, Radix Angelicae Dahuricae 1-40 part, Radix Clematidis 5-15 part, Camphora 2-8 part, chilli oil 2-8 part.
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is made: Caulis et folium stauntoniae 10-50 part, Cortex Eucommiae 1-30 part, Radix Angelicae Dahuricae 1-40 part, Radix Clematidis 5-15 part, Olibanum 5-15 part, Camphora 2-8 part, Borneolum Syntheticum 2-8 part, chilli oil 2-8 part.
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is made: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Clematidis, 10 parts of Olibanums, 5 parts of Camphoras, 5 parts of Borneolum Syntheticums, 5 parts of chilli oils, 6 parts on Flos Carthami, 6 parts of Radix Angelicae Pubescentiss, 6 parts of the Fructus Kochiae, 3 parts of Rhizoma Chuanxiongs, 3 parts of Cortex Acanthopanciss, 3 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).
Treat the preparation technology of rheumatoid Caulis et folium stauntoniae patch, have the following steps: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, pulverize, add in 120 parts of PURs that melt under 100 ° of C conditions, stirring boiled 30 minutes, filter, pour into and make the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Treat the preparation technology of rheumatoid Caulis et folium stauntoniae patch, have the following steps: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, 70% the ethanol that adds 8 times of the medical material gross weight decocts 3 times, each 30 minutes, merges 3 times decoction liquor, filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, add 120 parts in the PUR of 100 ° of C fusings, stirred 10 minutes, and filtered, pour into and make the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Treat the preparation technology of rheumatoid Caulis et folium stauntoniae patch, have the following steps: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, 8 times the decocting that adds the medical material gross weight boils 3 times, each 40 minutes, merge 3 times decoction liquor, filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, at 40 ° of C stirring in water bath homogeneous, in extractum, add 120 parts of acrylate pressure-sensitive adhesives, 150 r/min stir 30 minutes to even, leave standstill the degassing 30 minutes 40 ° of C water-baths, film,, cover back of the body village after the cooling and get product dry 20 minutes of 80 ° of C; Wherein the polyacrylate pressure-sensitive model is Duro-Tak 87-2677, available from national of the United States's starch company (Shanghai).
Treat the preparation technology of rheumatoid Caulis et folium stauntoniae rheumatism oil, have the following steps: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, the soak with ethanol 30 days that adds 100 part 99%, cross the filtering solid residue, obtain soak, soak and 40 parts of vegetable oil mix by weight ratio finished product; Wherein vegetable oil comprises: 2 parts of Oleum Cinnamomi, 1 part of Oleum Caryophylli, 1 part of eucalyptus oil, 9 parts of Oleum Terebinthinaes, 27 parts of wintergreen oils.
Caulis et folium stauntoniae external preparation of the present invention is by skin effect administration, and Caulis et folium stauntoniae oral medication rheumatoid be after absorbing by digestive tract again by blood circulation to the whole body administration, with form of medication of the present invention greatest differences is arranged.
The percutaneous drug delivery mode of Caulis et folium stauntoniae and the blood circulation of Caulis et folium stauntoniae to whole body administering mode all have and do not have necessary relation between the therapeutic effect.
The invention has the advantages that: therapeutic effect is good, and optimum range is wide, is the treatment feature with the external, and toxic and side effects is little, and is easy to use.
Optimum range of the present invention: the present invention is the treatment feature with the external, toxic and side effects is little, easy to use, rheumatic arthritis, rheumatoid arthritis, sciatic neuropathy, muscular soreness etc. are had the effect of auxiliary treatment and relaxing muscles and tendons and activating QI and blood in the collateral, particularly rheumatoid arthritis is had certain therapeutic effect.
Therapeutic Method of the present invention:
Rheumatism patch administrated method: the Caulis et folium stauntoniae patch is attached to affected parts such as arthritis sore spot, makes it fit tightly the affected part with the palm applying light, every day a slice.
Rheumatism oil administrated method: Caulis et folium stauntoniae rheumatism oil number droplet is smeared affected parts such as arthritis sore spot, with the position that finger tip is ached in the affected part most, to carry out suitable massage, finger pressure, massage, rub by 2-3 minutes, the light earlier back of dynamics is heavy, do not feel misery with the patient and be advisable, every day 3 times.
The specific embodiment
Embodiment 1
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is made: 10 parts of Caulis et folium stauntoniaes.
Wherein preparation technology as follows: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, pulverize, add in 120 parts of PURs that under 100 ° of C conditions, melt, stir and boiled filtration 30 minutes, pour into and make the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Embodiment 2
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is made: 30 parts of Caulis et folium stauntoniaes.
Wherein preparation technology as follows: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, 70% the ethanol that adds 8 times of the medical material gross weight decocts 3 times, each 30 minutes, merge 3 times decoction liquor, filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, adds 120 parts in the PUR of 100 ° of C fusings, stirs 10 minutes, filter, pour into and make the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Embodiment 3
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is made: 25 parts of Caulis et folium stauntoniaes.
Wherein preparation technology as follows: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, 8 times the decocting that adds the medical material gross weight boils 3 times, each 40 minutes, merge 3 times decoction liquor, filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, at 40 ° of C stirring in water bath homogeneous, in extractum, add 120 parts of acrylate pressure-sensitive adhesives, 150 r/min stir 30 minutes to evenly, leave standstill the degassing 30 minutes 40 ° of C water-baths, film, dry 20 minutes of 80 ° of C, cover back of the body village after the cooling and get product.
Embodiment 4
Treat rheumatoid Caulis et folium stauntoniae external preparation, it contains the medicament that the following weight proportion raw material is made: 50 parts of Caulis et folium stauntoniaes.
Wherein preparation technology is as follows: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, adds 100 part 99% soak with ethanol 30 days, mistake filtering solid residue obtains soak, soak and 40 parts of vegetable oil mix by weight ratio finished product; Wherein vegetable oil comprises: 2 parts of Oleum Cinnamomi, 1 part of Oleum Caryophylli, 1 part of eucalyptus oil, 9 parts of Oleum Terebinthinaes, 27 parts of wintergreen oils.
Embodiment 5
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is made: 10 parts of Caulis et folium stauntoniaes, 1 part of the Cortex Eucommiae, 1 part of the Radix Angelicae Dahuricae, 5 parts of Radix Clematidis, 2 parts of Camphoras, 2 parts of chilli oils.
Wherein preparation technology is with embodiment 1.
Embodiment 6
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is made: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Clematidis, 5 parts of Camphoras, 5 parts of chilli oils.
Wherein preparation technology is with embodiment 2.
Embodiment 7
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is made: 25 parts of Caulis et folium stauntoniaes, 20 parts of the Cortexs Eucommiae, 15 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Clematidis, 6 parts of Camphoras, 6 parts of chilli oils.
Wherein preparation technology is with embodiment 3.
Embodiment 8
Treat rheumatoid Caulis et folium stauntoniae patch, contain the medicament that the following weight proportion raw material is made: 50 parts of Caulis et folium stauntoniaes, 30 parts of the Cortexs Eucommiae, 40 parts of the Radixs Angelicae Dahuricae, 15 parts of Radix Clematidis, 8 parts of Camphoras, 8 parts of chilli oils.
Wherein preparation technology is with embodiment 4.
Embodiment 9
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is made: 10 parts of Caulis et folium stauntoniaes, 1 part of the Cortex Eucommiae, 1 part of the Radix Angelicae Dahuricae, 5 parts of Radix Clematidis, 5 parts of Olibanums, 2 parts of Camphoras, 2 parts of Borneolum Syntheticums, 2 parts of chilli oils.
Wherein preparation technology is with embodiment 1.
Embodiment 10
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is made: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Clematidis, 10 parts of Olibanums, 5 parts of Camphoras, 5 parts of Borneolum Syntheticums, 5 parts of chilli oils.
Wherein preparation technology is with embodiment 2.
Embodiment 11
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is made: 25 parts of Caulis et folium stauntoniaes, 20 parts of the Cortexs Eucommiae, 25 parts of the Radixs Angelicae Dahuricae, 8 parts of Radix Clematidis, 8 parts of Olibanums, 6 parts of Camphoras, 6 parts of Borneolum Syntheticums, 6 parts of chilli oils.
Wherein preparation technology is with embodiment 3.
Embodiment 12
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is made: 50 parts of Caulis et folium stauntoniaes, 30 parts of the Cortexs Eucommiae, 40 parts of the Radixs Angelicae Dahuricae, 15 parts of Radix Clematidis, 15 parts of Olibanums, 8 parts of Camphoras, 8 parts of Borneolum Syntheticums, 8 parts of chilli oils.
Wherein preparation technology is with embodiment 4.
Embodiment 13
Treat rheumatoid Caulis et folium stauntoniae external preparation, contain the medicament that the following weight proportion raw material is made: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Clematidis, 10 parts of Olibanums, 5 parts of Camphoras, 5 parts of Borneolum Syntheticums, 5 parts of chilli oils, 6 parts on Flos Carthami, 6 parts of Radix Angelicae Pubescentiss, 6 parts of the Fructus Kochiae, 3 parts of Rhizoma Chuanxiongs, 3 parts of Cortex Acanthopanciss, 3 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).
Wherein preparation technology as follows: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, 70% the ethanol that adds 8 times of the medical material gross weight decocts 3 times, each 30 minutes, merge 3 times decoction liquor, filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, adds 120 parts in the PUR of 100 ° of C fusings, stirs 10 minutes, filter, pour into and make the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
Efficacy experiment:
Accept 650 routine patients for medical treatment, meet following condition: joint and part muscle swelling, distortion, pain, joint stuffiness, stiff person.Wherein the course of disease is the longest 48 years, minimum 22 years old of age, maximum 79 years old, women 316 people, male 334 people.This 650 routine patient is equally divided into the 1-13 group, and the Caulis et folium stauntoniae external preparation that makes with embodiment 1-13 group is treated respectively.
During the treatment: do not take the rheumatoid Chinese medicine and western medicine of other treatment.
Standards of grading:
Local joint disease is given the classification record: joint stiff time in morning, arthralgia index, joint swelling index, grip.(annotate: index closes joint number * integration for getting involved counts sum).Standards of grading are as follows: the stiff time in (1) morning: 0 minute: no morning deadlock.1 minute: morning, deadlock was less than 30min.2 minutes: morning, deadlock was greater than 30min, less than 60min.3 minutes: morning, deadlock was greater than 60min.(2) arthralgia integration: 0 minute: no pain.1 minute: mild pain, tell pain during compressing.2 minutes: moderate pain, show painful expression during compressing, shrink back, do not influence sleep.3 minutes: severe pain, the inspection of refusal tenderness, influence sleep.(3) arthroncus integration: 0 minute: no swelling.1 minute: apophysis went out the position near mild swelling, swelling were lower than.2 minutes: it is flat that moderate swelling, swelling and near apophysis go out the position.3 minutes: apophysis went out the position near severe swelling, swelling exceeded.(4) joint allomeric function integration: 0 minute: no joint dysfunction; 1 minute: slight dysfunction, though one or multiarticulate function limitation are arranged, can be engaged in normal activity.2 minutes: moderate joint function disturbance, function of joint were obviously limited, and life still can be taken care of oneself, but can not be engaged in general activity.3 minutes: the severe joint function disturbance, bed or wheelchair be can't take care of oneself.
Criterion of therapeutical effect:
Produce effects: observation index treatment back integration summation descends 〉=70% than the preceding integration summation of treatment.Effectively: observation index treatment back integration summation descends 〉=50% than the preceding integration summation of treatment, but＜70%.Improve: observation index treatment back integration summation descends 〉=30% than integration summation before treating, but＜50%.Invalid: observation index treatment back integration summation descends＜30% than the preceding integration summation of treatment.
Integral and calculating: integration summation * 100% before (integration summation before the treatment-treatment back integration summation)/treatment
Therapeutic effect:
From efficacy experiment as can be seen Caulis et folium stauntoniae the treatment rheumatoid disease is all had certain curative effect is arranged, particularly the rheumatoid Chinese medicine of Caulis et folium stauntoniae and other treatment is composite, and good especially therapeutic effect is arranged.
Claims (10)
1. the application of Caulis et folium stauntoniae in preparation rheumatoid oral formulations.
2. the application of Caulis et folium stauntoniae in preparation rheumatoid external preparation.
3. the rheumatoid Caulis et folium stauntoniae external preparation of treatment is characterized in that it contains the medicament that the following weight proportion raw material is made: Caulis et folium stauntoniae 10-50 part.
4. the rheumatoid Caulis et folium stauntoniae external preparation of treatment is characterized in that it contains the medicament that the following weight proportion raw material is made: Caulis et folium stauntoniae 10-50 part, Cortex Eucommiae 1-30 part, Radix Angelicae Dahuricae 1-40 part, Radix Clematidis 5-15 part, Camphora 2-8 part, chilli oil 2-8 part.
5. the rheumatoid Caulis et folium stauntoniae external preparation of treatment is characterized in that it contains the medicament that the following weight proportion raw material is made: Caulis et folium stauntoniae 10-50 part, Cortex Eucommiae 1-30 part, Radix Angelicae Dahuricae 1-40 part, Radix Clematidis 5-15 part, Olibanum 5-15 part, Camphora 2-8 part, Borneolum Syntheticum 2-8 part, chilli oil 2-8 part.
6. the rheumatoid Caulis et folium stauntoniae external preparation of treatment is characterized in that it contains the medicament that the following weight proportion raw material is made: 30 parts of Caulis et folium stauntoniaes, 15 parts of the Cortexs Eucommiae, 20 parts of the Radixs Angelicae Dahuricae, 10 parts of Radix Clematidis, 10 parts of Olibanums, 5 parts of Camphoras, 5 parts of Borneolum Syntheticums, 5 parts of chilli oils, 6 parts on Flos Carthami, 6 parts of Radix Angelicae Pubescentiss, 6 parts of the Fructus Kochiae, 3 parts of Rhizoma Chuanxiongs, 3 parts of Cortex Acanthopanciss, 3 parts on Cortex cinnamomi japonici (Ramulus Cinnamomi).
7. as any preparation method for the treatment of rheumatoid Caulis et folium stauntoniae external preparation among the claim 3-6, it is characterized in that having the following steps: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, pulverize, add in 120 parts of PURs that melt under 100 ° of C conditions, stirring boiled 30 minutes, filter, pour into and make the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
8. as any preparation method for the treatment of rheumatoid Caulis et folium stauntoniae external preparation among the claim 3-6, it is characterized in that having the following steps: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, 70% the ethanol that adds 8 times of the medical material gross weight decocts 3 times, each 30 minutes, merge 3 times decoction liquor, filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, add 120 parts in the PUR of 100 ° of C fusings, stirred 10 minutes, and filtered, pour into and make the cream sheet in the doctor knife coater, through tabletting and washer, last packed products.
9. as any preparation method for the treatment of rheumatoid Caulis et folium stauntoniae external preparation among the claim 3-6, it is characterized in that having the following steps: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, 8 times the decocting that adds the medical material gross weight boils 3 times, each 40 minutes, merge 3 times decoction liquor, filter, and concentrate, proportion is 1.10 fluid extract when obtaining 60 ℃, at 40 ° of C stirring in water bath homogeneous, in extractum, add 120 parts of acrylate pressure-sensitive adhesives, 150 r/min stir 30 minutes to even, leave standstill the degassing 30 minutes 40 ° of C water-baths, film,, cover back of the body village after the cooling and get product dry 20 minutes of 80 ° of C; Wherein the polyacrylate pressure-sensitive model is Duro-Tak 87-2677, available from national of the United States's starch company (Shanghai).
10. as any preparation method for the treatment of rheumatoid Caulis et folium stauntoniae external preparation among the claim 3-6, it is characterized in that having the following steps: the Chinese crude drug in the raw material is cleaned, be mixed in proportion, the soak with ethanol 30 days that adds 100 part 99%, cross the filtering solid residue, obtain soak, soak and 40 parts of vegetable oil mix by weight ratio finished product; Wherein vegetable oil comprises: 2 parts of Oleum Cinnamomi, 1 part of Oleum Caryophylli, 1 part of eucalyptus oil, 9 parts of Oleum Terebinthinaes, 27 parts of wintergreen oils.
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| CN108498634A (en) * | 2017-11-01 | 2018-09-07 | 王健民 | A kind of externally applied drug of rheumatoid arthritis and its preparation method and application |
| CN108478645A (en) * | 2018-07-04 | 2018-09-04 | 尚青青 | A kind of Chinese medicine composition and Chinese medicinal liniment and its preparation method and application |
| CN109464551A (en) * | 2018-12-07 | 2019-03-15 | 怀化五零三侗医药科技开发有限公司 | Wind resistance wet gel and preparation method thereof |
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