CN111904997A - Compound Chinese herbal medicine gel for promoting blood circulation and preparation method and application thereof - Google Patents
Compound Chinese herbal medicine gel for promoting blood circulation and preparation method and application thereof Download PDFInfo
- Publication number
- CN111904997A CN111904997A CN202010825376.1A CN202010825376A CN111904997A CN 111904997 A CN111904997 A CN 111904997A CN 202010825376 A CN202010825376 A CN 202010825376A CN 111904997 A CN111904997 A CN 111904997A
- Authority
- CN
- China
- Prior art keywords
- parts
- blood circulation
- water
- gel
- herbal medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000017531 blood circulation Effects 0.000 title claims abstract description 76
- 150000001875 compounds Chemical class 0.000 title claims abstract description 58
- 241000411851 herbal medicine Species 0.000 title claims abstract description 51
- 238000002360 preparation method Methods 0.000 title claims description 18
- 230000001737 promoting effect Effects 0.000 title description 26
- 239000003814 drug Substances 0.000 claims abstract description 87
- 239000011159 matrix material Substances 0.000 claims abstract description 39
- 230000003213 activating effect Effects 0.000 claims abstract description 36
- 229940079593 drug Drugs 0.000 claims abstract description 25
- 239000004863 Frankincense Substances 0.000 claims abstract description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 21
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 18
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 18
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 18
- 244000223760 Cinnamomum zeylanicum Species 0.000 claims abstract description 18
- 240000007311 Commiphora myrrha Species 0.000 claims abstract description 18
- 235000006965 Commiphora myrrha Nutrition 0.000 claims abstract description 18
- 235000007265 Myrrhis odorata Nutrition 0.000 claims abstract description 18
- 235000017803 cinnamon Nutrition 0.000 claims abstract description 18
- 239000004520 water soluble gel Substances 0.000 claims abstract description 18
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 16
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 16
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 16
- 241001180876 Saposhnikovia Species 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 16
- 201000010099 disease Diseases 0.000 claims abstract description 14
- 241000212322 Levisticum officinale Species 0.000 claims abstract description 12
- 239000001645 levisticum officinale Substances 0.000 claims abstract description 12
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 11
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 5
- 239000007822 coupling agent Substances 0.000 claims abstract description 4
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 57
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 51
- 239000002904 solvent Substances 0.000 claims description 36
- 208000002193 Pain Diseases 0.000 claims description 35
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 33
- 239000000463 material Substances 0.000 claims description 20
- 238000000605 extraction Methods 0.000 claims description 16
- 238000010992 reflux Methods 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 241000125175 Angelica Species 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 15
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 12
- 229960003639 laurocapram Drugs 0.000 claims description 12
- 241000758794 Asarum Species 0.000 claims description 10
- 241000218378 Magnolia Species 0.000 claims description 10
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 9
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 9
- 239000000243 solution Substances 0.000 claims description 9
- 241000112528 Ligusticum striatum Species 0.000 claims description 8
- 206010034464 Periarthritis Diseases 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 8
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 230000005484 gravity Effects 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 239000003895 organic fertilizer Substances 0.000 claims description 7
- 238000001556 precipitation Methods 0.000 claims description 7
- 208000005171 Dysmenorrhea Diseases 0.000 claims description 6
- 206010013935 Dysmenorrhoea Diseases 0.000 claims description 6
- 201000001245 periodontitis Diseases 0.000 claims description 5
- 206010033557 Palpitations Diseases 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 201000009151 chronic rhinitis Diseases 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 206010039083 rhinitis Diseases 0.000 claims description 4
- 206010005963 Bone formation increased Diseases 0.000 claims description 3
- 201000005569 Gout Diseases 0.000 claims description 3
- 206010019233 Headaches Diseases 0.000 claims description 3
- 206010028748 Nasal obstruction Diseases 0.000 claims description 3
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 3
- 240000007164 Salvia officinalis Species 0.000 claims description 3
- 206010041591 Spinal osteoarthritis Diseases 0.000 claims description 3
- 201000010105 allergic rhinitis Diseases 0.000 claims description 3
- 208000036319 cervical spondylosis Diseases 0.000 claims description 3
- 231100000869 headache Toxicity 0.000 claims description 3
- 201000009240 nasopharyngitis Diseases 0.000 claims description 3
- 201000007094 prostatitis Diseases 0.000 claims description 3
- 208000005801 spondylosis Diseases 0.000 claims description 3
- 230000008736 traumatic injury Effects 0.000 claims description 3
- 241000382455 Angelica sinensis Species 0.000 claims description 2
- 235000017276 Salvia Nutrition 0.000 claims description 2
- 206010040007 Sense of oppression Diseases 0.000 claims description 2
- 238000001467 acupuncture Methods 0.000 claims description 2
- 239000003125 aqueous solvent Substances 0.000 claims description 2
- 239000000047 product Substances 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 9
- 230000009471 action Effects 0.000 abstract description 4
- 238000002651 drug therapy Methods 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract description 4
- 238000011068 loading method Methods 0.000 abstract description 4
- 238000000554 physical therapy Methods 0.000 abstract description 4
- 230000007246 mechanism Effects 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 30
- 210000004369 blood Anatomy 0.000 description 24
- 239000008280 blood Substances 0.000 description 24
- 244000132619 red sage Species 0.000 description 12
- 230000006870 function Effects 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 230000001154 acute effect Effects 0.000 description 9
- 239000006071 cream Substances 0.000 description 8
- 230000008961 swelling Effects 0.000 description 8
- 210000003205 muscle Anatomy 0.000 description 7
- 239000002674 ointment Substances 0.000 description 7
- 229940126680 traditional chinese medicines Drugs 0.000 description 7
- 206010024453 Ligament sprain Diseases 0.000 description 6
- 230000004089 microcirculation Effects 0.000 description 6
- -1 angelone Chemical compound 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 230000001684 chronic effect Effects 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010067484 Adverse reaction Diseases 0.000 description 3
- 208000025978 Athletic injury Diseases 0.000 description 3
- 241000717739 Boswellia sacra Species 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 230000006838 adverse reaction Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 210000002097 psoas muscle Anatomy 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 210000003813 thumb Anatomy 0.000 description 3
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 description 2
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 description 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 2
- IQVQXVFMNOFTMU-FLIBITNWSA-N (Z)-ligustilide Chemical compound C1CC=CC2=C1C(=C/CCC)/OC2=O IQVQXVFMNOFTMU-FLIBITNWSA-N 0.000 description 2
- HYXITZLLTYIPOF-UHFFFAOYSA-N 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(C)(C)C3=CC=C2C2=C1C(C)=CO2 HYXITZLLTYIPOF-UHFFFAOYSA-N 0.000 description 2
- BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 2
- HJXMNVQARNZTEE-UHFFFAOYSA-N Butylphthalide Chemical compound C1=CC=C2C(CCCC)OC(=O)C2=C1 HJXMNVQARNZTEE-UHFFFAOYSA-N 0.000 description 2
- PKRPFNXROFUNDE-LLVKDONJSA-N Byakangelicin Chemical compound O1C(=O)C=CC2=C1C(OC[C@@H](O)C(C)(C)O)=C1OC=CC1=C2OC PKRPFNXROFUNDE-LLVKDONJSA-N 0.000 description 2
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- 208000001953 Hypotension Diseases 0.000 description 2
- 241001057584 Myrrha Species 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 201000002661 Spondylitis Diseases 0.000 description 2
- 206010041738 Sports injury Diseases 0.000 description 2
- AIGAZQPHXLWMOJ-UHFFFAOYSA-N Tanshinone I Chemical compound C1=CC2=C(C)C=CC=C2C(C(=O)C2=O)=C1C1=C2C(C)=CO1 AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 description 2
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 description 2
- IQVQXVFMNOFTMU-DHZHZOJOSA-N Z-ligustilide Natural products C1CC=CC2=C1C(=C/CCC)\OC2=O IQVQXVFMNOFTMU-DHZHZOJOSA-N 0.000 description 2
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 description 2
- 229940036350 bisabolol Drugs 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 2
- 229940117916 cinnamic aldehyde Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 210000004247 hand Anatomy 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 2
- 238000013271 transdermal drug delivery Methods 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- BLSQLHNBWJLIBQ-OZXSUGGESA-N (2R,4S)-terconazole Chemical compound C1CN(C(C)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2N=CN=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 BLSQLHNBWJLIBQ-OZXSUGGESA-N 0.000 description 1
- QBLFZIBJXUQVRF-UHFFFAOYSA-N (4-bromophenyl)boronic acid Chemical compound OB(O)C1=CC=C(Br)C=C1 QBLFZIBJXUQVRF-UHFFFAOYSA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- MPIPASJGOJYODL-SFHVURJKSA-N (R)-isoconazole Chemical compound ClC1=CC(Cl)=CC=C1[C@@H](OCC=1C(=CC=CC=1Cl)Cl)CN1C=NC=C1 MPIPASJGOJYODL-SFHVURJKSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 description 1
- XBGUIVFBMBVUEG-UHFFFAOYSA-N 1-methyl-4-(1,5-dimethyl-4-hexenylidene)-1-cyclohexene Chemical compound CC(C)=CCCC(C)=C1CCC(C)=CC1 XBGUIVFBMBVUEG-UHFFFAOYSA-N 0.000 description 1
- NBGQZFQREPIKMG-UHFFFAOYSA-N 3beta-hydroxy-beta-boswellic acid Natural products C1CC(O)C(C)(C(O)=O)C2CCC3(C)C4(C)CCC5(C)CCC(C)C(C)C5C4=CCC3C21C NBGQZFQREPIKMG-UHFFFAOYSA-N 0.000 description 1
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
- SODWJACROGQSMM-UHFFFAOYSA-N 5,6,7,8-tetrahydronaphthalen-1-amine Chemical compound C1CCCC2=C1C=CC=C2N SODWJACROGQSMM-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- DBMJZOMNXBSRED-UHFFFAOYSA-N Bergamottin Natural products O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC=C(C)CCC=C(C)C DBMJZOMNXBSRED-UHFFFAOYSA-N 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- NBGQZFQREPIKMG-PONOSELZSA-N Boswellic acid Chemical compound C1C[C@@H](O)[C@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C NBGQZFQREPIKMG-PONOSELZSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 244000052909 Dioscorea esculenta Species 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- QURCVMIEKCOAJU-HWKANZROSA-N Isoferulic acid Natural products COC1=CC=C(\C=C\C(O)=O)C=C1O QURCVMIEKCOAJU-HWKANZROSA-N 0.000 description 1
- 206010061225 Limb injury Diseases 0.000 description 1
- 208000029549 Muscle injury Diseases 0.000 description 1
- 206010049816 Muscle tightness Diseases 0.000 description 1
- 206010052904 Musculoskeletal stiffness Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010061876 Obstruction Diseases 0.000 description 1
- 208000028571 Occupational disease Diseases 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- 241001310793 Podium Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010039020 Rhabdomyolysis Diseases 0.000 description 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 208000026137 Soft tissue injury Diseases 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 241000830536 Tripterygium wilfordii Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- YHBUQBJHSRGZNF-HNNXBMFYSA-N alpha-bisabolene Natural products CC(C)=CCC=C(C)[C@@H]1CCC(C)=CC1 YHBUQBJHSRGZNF-HNNXBMFYSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 210000002565 arteriole Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229960002045 bergapten Drugs 0.000 description 1
- KGZDKFWCIPZMRK-UHFFFAOYSA-N bergapten Natural products COC1C2=C(Cc3ccoc13)C=CC(=O)O2 KGZDKFWCIPZMRK-UHFFFAOYSA-N 0.000 description 1
- PKRPFNXROFUNDE-UHFFFAOYSA-N biac-angelicin Natural products O1C(=O)C=CC2=C1C(OCC(O)C(C)(C)O)=C1OC=CC1=C2OC PKRPFNXROFUNDE-UHFFFAOYSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 229930003493 bisabolene Natural products 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229950005197 butylphthalide Drugs 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 229960002896 clonidine Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229960003645 econazole nitrate Drugs 0.000 description 1
- 230000002497 edematous effect Effects 0.000 description 1
- 210000000750 endocrine system Anatomy 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 229940088592 immunologic factor Drugs 0.000 description 1
- OLOOJGVNMBJLLR-UHFFFAOYSA-N imperatorin Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OCC=C(C)C OLOOJGVNMBJLLR-UHFFFAOYSA-N 0.000 description 1
- XKVWLLRDBHAWBL-UHFFFAOYSA-N imperatorin Natural products CC(=CCOc1c2OCCc2cc3C=CC(=O)Oc13)C XKVWLLRDBHAWBL-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000013101 initial test Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000011256 inorganic filler Substances 0.000 description 1
- 229910003475 inorganic filler Inorganic materials 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- 229960004849 isoconazole Drugs 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 238000010907 mechanical stirring Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 208000013465 muscle pain Diseases 0.000 description 1
- 201000000585 muscular atrophy Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 208000026843 stiff neck Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000000194 supercritical-fluid extraction Methods 0.000 description 1
- 229930189533 tanshinol Natural products 0.000 description 1
- 229960000580 terconazole Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 235000015398 thunder god vine Nutrition 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000000264 venule Anatomy 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
Abstract
The invention provides a blood-activating compound Chinese herbal medicine gel, which comprises 900 parts of 500-one of angelica, 500 parts of 300-one of cinnamon, 0-500 parts of myrrh, 0-500 parts of frankincense, 500 parts of divaricate saposhnikovia root, 500 parts of 300-one of szechuan lovage rhizome, 500 parts of 300-one of salvia miltiorrhiza, 500 parts of 300-one of angelica dahurica and 5500 parts of 3000-one of water-soluble gel matrix; the water-soluble gel matrix is prepared from the following raw material medicines in parts by mass: 600 portions of polyacrylate 300-. The compound Chinese herbal medicine gel for activating blood circulation achieves remarkable blood circulation activating effect by the mutual matching of different action mechanisms through the selection and content setting of the components, can be used for relieving and treating various diseases, has good compatibility of the gel matrix and the traditional Chinese medicine components, large drug-loading rate, is beneficial to the permeation and absorption of the skin, is comfortable and convenient to apply, and has small irritation to the skin. The invention can be used as a drug coupling agent for ultrasonic therapeutic equipment, and effectively combines two methods of physical therapy and drug therapy.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a compound Chinese herbal medicine gel for promoting blood circulation, and a preparation method and application thereof.
Background
Blood circulates through vessels and circulates throughout the viscera and tissues of the whole body to nourish and moisten the internal organs, the bones and limbs, the five sense organs, the nine orifices, the skin, the muscles and bones, and is one of the basic substances constituting the human body and maintaining the life activities of the human body. Ancient Chinese medicine famous families pay attention to the treatment of all diseases by promoting blood circulation, and the pain is mostly caused by blood circulation loss. The degree of the method is seen in modern medicine and comprises performance indexes of vessel wall stress, relaxation of microvessels, sedimentation rate of red blood cells, aggregative property and deformability; adhesion and aggregation of erythrocytes and platelets, as well as plasma protein content, coagulation factors, cell membrane function and immune factor status, etc. In the blood circulation, the circulation from arterioles to venules is the most basic unit, commonly known as microcirculation. The blood flow in the microcirculation can account for more than 60 percent of the blood flow of the human body, and has good regulating effect on the human body flow. Microcirculation is not only the conduit through which blood flows, the organs that regulate blood, and the places where exchange of substances takes place, but also an endocrine system that functions extensively and secretes a variety of bioactive substances. The microcirculation system is controlled by the multiple sensory nerves and the factors of body fluid, which can regulate the activity of itself and can interact with other tissues and organs. Therefore, the function of the microcirculation system can be improved, the capability of maintaining the normal physiological activity of the organism can be improved, and the aim of treating the abnormal diseases simultaneously can be achieved. The actions and mechanisms of blood circulation are basically consistent in TCM and Western medicine. The medicine for treating blood circulation disorder adopts the pharmacodynamic components of plant traditional Chinese medicines in the last two decades, makes great progress in pharmacological research through compound combination, has obvious pharmacodynamic component action, reduces toxic and side effects through reasonable extraction, and has relatively low cost.
The extraction of the effective components of the traditional Chinese medicine is not simple decoction but solvent extraction in the modern pharmaceutical technology, wherein the method is combined with mechanical stirring or ultrasonic wave means, and also comprises the methods of supercritical extraction, macroporous adsorption resin separation, ion exchange resin separation, membrane separation and membrane concentration, freeze drying, enzymolysis and the like. However, the method of extracting single or compound Chinese herbal medicine by using mixed solvent is still an effective and economical method. The treatment of blood circulation disorders is mainly physical therapy and drug therapy, and drug therapy is still an important treatment means. In terms of administration, most of the drugs are mainly administered orally, and transdermal administration and therapeutic techniques have been developed in recent years. In the aspect of treating local microcirculation disturbance, oral medicines need to use larger dosage to maintain effective blood concentration and local medicine concentration, and are easy to cause a plurality of adverse reactions. In addition, the stimulation of the gastrointestinal tract by the liver passage effect which may occur by oral administration is not negligible, and specific substances in certain foods and oral drugs are also likely to have an effect in the intestinal tract. Recently, there is a medical literature report in China that grapefruit contains a biological substance CYP-3A4, which is subjected to enzymolysis and acts with simvastatin for treating hyperlipidemia, thereby causing muscle dissolution, muscle pain and nephropathy; when acting with hypotensive drugs, it can cause hypotension and muscular atrophy; if it acts with antiallergic drugs, dizziness and palpitation occur in mild cases, and sudden death occurs in severe cases. It is thought that these side effects can be avoided by transdermal administration or injection.
In recent years, the technology of transdermal drug delivery preparation attracts attention, but the technology is not advanced much, and western medicines of transdermal absorption gel, listed in the 'new dosage form of transdermal drug delivery' edited by zheng junmin, mostly contain clonidine, econazole nitrate, isoconazole, terconazole and antibiotics. The traditional Chinese medicine adopts single or two or three mixed medicines of salvia miltiorrhiza, pseudo-ginseng, borneol, tripterygium wilfordii, ligusticum wallichii, angelica and safflower, and cannot form a complete prescription with complete main and auxiliary combination. Moreover, the extraction of the medicinal components is lagged behind, the medicinal effect is difficult to exert, and great waste is caused.
Disclosure of Invention
The invention aims to provide a multi-purpose Chinese medicinal compound gel with the function of promoting blood circulation, which has the advantages of large drug-loading rate, good biocompatibility, easy absorption of the medicament by skin, quick curative effect, small skin irritation and little anaphylactic reaction. The invention also aims to provide a preparation method and application of the traditional Chinese medicine compound gel preparation.
In order to achieve the purpose, the invention adopts the following technical scheme:
a compound Chinese herbal medicine gel for invigorating blood circulation is prepared from the following raw material medicines in parts by mass: 900 parts of 500-materials of angelica, 500 parts of 300-materials of cinnamon, 0-500 parts of myrrh, 0-500 parts of frankincense, 500 parts of divaricate saposhnikovia root, 500 parts of szechuan lovage rhizome, 500 parts of 300-materials of salvia miltiorrhiza, 500 parts of 300-materials of angelica and 5500 parts of 3000-materials of water-soluble gel matrix;
the water-soluble gel matrix is prepared from the following raw material medicines in parts by mass: 600 portions of polyacrylate 300-.
Modern techniques have been able to analyze the specific components of many traditional Chinese medicines. The radix Angelicae sinensis contains ligustilide, angelone, carvacrol, ester n-butyrolactone, ferulic acid, succinic acid, nicotinic acid, primidine, adenine and polysaccharide. Cortex Cinnamomi contains cinnamaldehyde, cinnamic acid, and cinnamyl glycoside. The rhizoma Ligustici Chuanxiong contains tetramethylpyrazine, ligustilide and butylphthalide. Radix Saposhnikoviae contains alpha- ene, octanal, cimicifugal element, and psoralen. The radix Angelicae Dahuricae comprises byak-angelicin, imperatorin, bergapten, alpha-levo-myrcene, and cyclopentadecyl ester. The Saviae Miltiorrhizae radix contains tanshinone I, tanshinone II, tanshinol and isoferulic acid. Myrrha comprises bisabolene, cinnamaldehyde, limonene, bisabolol, and bisabolol E and Z. The Olibanum contains alpha, beta boswellic acid, boswellic resin, hydrocarbon and Olibanum terpene. Most of the above traditional Chinese medicine components have the function of promoting blood circulation.
In the invention, preferably, the compound Chinese herbal medicine gel for activating blood circulation is prepared from the following raw material medicines in parts by mass: 900 parts of 500-materials of angelica, 500 parts of 300-materials of cinnamon, 0-500 parts of myrrh, 0-500 parts of frankincense, 500 parts of divaricate saposhnikovia root, 500 parts of szechuan lovage rhizome, 0-500 parts of asarum, 0-500 parts of magnolia flower, 500 parts of 300-materials of salvia, 500 parts of 300-materials of angelica and 5500 parts of 3000-materials of water-soluble gel matrix. Further preferably, the compound Chinese herbal medicine gel for activating blood circulation is prepared from the following raw material medicines in parts by mass: 800 portions of 600-containing angelica, 500 portions of 300-containing cinnamon, 400 portions of 300-containing myrrh, 300 portions of frankincense, 500 portions of 400-containing divaricate saposhnikovia root, 500 portions of 400-containing ligusticum wallichii, 300 portions of 100-containing asarum, 300 portions of magnolia flower, 400 portions of 300-containing salvia miltiorrhiza, 400 portions of 300-containing angelica and 5000 portions of 4000-containing water-soluble gel matrix.
The invention relates to a blood-activating compound Chinese herbal medicine gel raw material medicine which is prepared from Chinese angelica, cinnamon, ligusticum wallichii, radix sileris, asarum, biond magnolia flower, radix angelicae, myrrh, frankincense and salvia miltiorrhiza. According to the research of traditional Chinese medicine pharmacology, the angelica, the ligusticum wallichii, the myrrh, the frankincense and the red sage root have the effects of improving the hemodynamics and increasing the blood flow of the femoral artery of the dog and reducing the vascular resistance. Zhongyun (compendium of materia Medica): "Ru Xiang Huo Xue, Mo Yao dispel blood, all can alleviate pain, reduce swelling, promote granulation, so two herbs are used for every one phase", modern pharmacology proves that Ru Xiang and Mo Yao can reduce inflammation obviously, permeability of capillary vessel is reduced obviously, and it has obvious functions of diminishing inflammation and easing pain. Radix Saposhnikoviae, radix Angelicae Dahuricae, and herba asari have antiinflammatory, analgesic, and antiallergic effects. The flower bud of flos Magnoliae contains volatile oil including citral, eugenol, 1, 8-cineole and alkaloid, and has effects of dilating blood vessel and reducing ganglion blocking. Cinnamon has the functions of dispelling cold, relieving pain, promoting blood circulation and removing obstruction in channels.
In the background art, the invention refers to the principle that ' pathological changes are more but the method is classified into one and ' the treatment of different diseases simultaneously '. The reasonable effective components of the compound Chinese herbal medicine can overcome the obstacle of the circulatory system. TCM contains profound philosophy, such as general regulation without pain to treat inflammation. For bleeding, it refers to blood stasis, blood failing to flow through the channels and overflowing the vessels, which causes various kinds of bleeding. For edema, the book jin Kui Yao L ü e states that "blood disorder is water", blood stagnation is formed into stasis, and water overflows the vessels and invades the skin, resulting in edema. Based on the theory of 'unobstructed blood vessels and all diseases eliminated', the traditional Chinese medicine compound gel with the blood circulation promoting function can be used for treating and relieving diseases caused by blood circulation disorder, such as traumatic injury, cervical spondylosis, scapulohumeral periarthritis, hyperosteogeny, periodontitis, otorrhitis, female dysmenorrhea, male prostatitis, gout and headache; nasal obstruction, chronic rhinitis and allergic rhinitis due to common cold; chest distress, palpitation, etc. The blood-activating medicine of the traditional Chinese medicine belongs to one of the blood-regulating medicines, and the blood-regulating medicine comprises a blood-nourishing medicine, a blood-activating medicine and a blood-cooling medicine. However, according to the principle of Chinese medicine, the Chinese medicinal components of the invention are perfectly compatible, and the medicaments have complementarity and reinforcement, which is the meaning of compound prescription.
The safety of the active ingredients contained in the traditional Chinese medicine compound gel with the function of activating blood circulation is discussed. Among 12807 traditional Chinese medicines discovered in China at present, no more than 120 traditional Chinese medicines possibly causing adverse reactions and no more than 50 traditional Chinese medicines possibly causing serious adverse reactions are available, so that the selection of safe and low-toxicity traditional Chinese medicines is feasible.
In the invention, preferably, the water-soluble gel matrix is prepared from the following raw material medicines in parts by mass: 400-500 parts of sodium polyacrylate, 200-300 parts of glycerol, 200-300 parts of propylene glycol, 200-200 parts of laurocapram, 3000-4000 parts of water and 25-50 parts of parabens.
In the invention, preferably, the compound Chinese herbal medicine gel for activating blood circulation is prepared from the following raw material medicines in parts by mass: 600 parts of angelica sinensis, 300 parts of cinnamon, 300 parts of myrrh, 300 parts of frankincense, 400 parts of divaricate saposhnikovia root, 400 parts of ligusticum wallichii, 200 parts of asarum, 200 parts of biond magnolia flower, 300 parts of salvia miltiorrhiza, 300 parts of radix angelicae and 4500 parts of water-soluble gel matrix; the water-soluble gel matrix is prepared from the following raw material medicines in parts by mass: 450 parts of sodium polyacrylate, 300 parts of glycerol, 300 parts of propylene glycol, 100 parts of laurocapram, 3500 parts of water and 30 parts of parabens.
Specifically, most of the medicines containing volatile oil, propylene glycol and laurocapram have the effect of helping the transdermal absorption of the medicines, and can be used as transdermal enhancers.
Specifically, the water-soluble gel matrix of the compound Chinese herbal medicine gel for promoting blood circulation is obtained by long-term experimental research of the inventor, all components are mutually matched, the compatibility of the gel matrix with the traditional Chinese medicine components is good, the medicine carrying amount is large, the gel matrix is favorable for penetrating and absorbing the skin, the smearing is comfortable and convenient, and the irritation to the skin is small. And the gel matrix is consistent with the water-soluble matrix of the medical ultrasonic couplant. The test proves that the compound Chinese herbal medicine gel for promoting blood circulation can be used as a sound conduction medium for an ultrasonic therapeutic apparatus. The effective components enhance the therapeutic effect. During the use of the ultrasonic treatment apparatus, it is noted that the frequency, power and penetration time of the ultrasound are suitable, which would otherwise cause damage to the cells and muscle tissue.
The invention also provides a preparation method of the compound Chinese herbal medicine gel for activating blood circulation, which comprises the following steps:
s1, sequentially carrying out alcohol extraction on Chinese medicinal components including Chinese angelica, cinnamon, myrrh, frankincense, divaricate saposhnikovia root, szechuan lovage rhizome, salvia miltiorrhiza and dahurian angelica root, wherein an alcohol extraction solvent is an aqueous solvent containing 75% of alcohol; the specific operation is that the alcohol extraction solvent is added into the traditional Chinese medicine components to reflux twice, the first time is that the solvent amount which is 10 times that of the traditional Chinese medicine components reflux for two hours, and the second time is that the solvent amount which is 8 times that of the traditional Chinese medicine components reflux for one hour; refluxing at 80-100 deg.C, filtering, mixing the filtrates, cooling to 10-20 deg.C, standing for 2-8 hr for precipitation, and concentrating the clear liquid to specific gravity of 1.05-1.08 to obtain ethanol extractive solution; preferably, the traditional Chinese medicine component alcohol is soaked in 95 percent ethanol aqueous solution for 3 to 8 hours in advance;
s2, sequentially adding glycerol, propylene glycol, water, laurocapram and parabens into polyacrylate according to the formula amount, and stirring to form a gel-like water-soluble matrix;
and S3, uniformly stirring the alcohol extract obtained in the step S1 and the water-soluble matrix obtained in the step S2 to obtain the water-soluble organic fertilizer.
Preferably, the propylene glycol in S2 is partially or completely added to the alcoholic solvent containing 75% aqueous ethanol solvent in S1, and the reflux temperature is raised to 120 ℃ or higher. Propylene glycol as a gel moisturizing component can be added into the original alcohol extraction solvent containing 75% of ethanol water solvent, the extraction reflux temperature can be increased to more than 120 ℃, the medicine components can be rapidly dissolved, and the addition amount of the propylene glycol can be partially added or can be added in full amount according to the proportion of the gel matrix. During the solvent recovery operation, only ethanol is distilled, and the propylene glycol still remains in the ethanol extract.
The compound Chinese herbal medicine gel for promoting blood circulation can be used for treating diseases caused by blood circulation disorder, wherein the diseases caused by the blood circulation disorder comprise traumatic injury, cervical spondylosis, scapulohumeral periarthritis, hyperosteogeny, periodontitis, otorrhitis, female dysmenorrhea, male prostatitis, gout and headache; nasal obstruction, chronic rhinitis and allergic rhinitis due to common cold; chest oppression and palpitation. The compound Chinese herbal medicine gel for invigorating blood circulation disclosed by the invention is orange red in color, looks like mud in appearance, does not contain clay and other inorganic fillers, is derived from natural pigments of Chinese herbal medicines in color, and is safe and environment-friendly.
Specifically, the use method of the compound Chinese herbal medicine gel for activating blood circulation provided by the invention comprises the following steps:
(1) applied to the external surface of the patient's skin;
(2) applying on affected part, and massaging pain point, channels and collaterals or acupuncture point;
(3) the foment package method can be adopted for treating scapulohumeral periarthritis;
(4) applied to the affected part, and absorbed by ultrasonic therapeutic apparatus.
The compound Chinese herbal medicine gel for promoting blood circulation has the following characteristics:
(1) the water-soluble gel type is comfortable and convenient to apply and has small irritation to skin.
(2) The degree of freedom of the skin administration range is large, and the absorption of the medicine is facilitated.
(3) The compatibility of the matrix and the medicine is good, the medicine loading capacity is large, and the skin permeation and absorption are facilitated.
(4) Is suitable for rubbing and massaging treatment methods.
(5) As a drug coupling agent used for an ultrasonic therapeutic apparatus, two methods of physical therapy and drug therapy are combined.
(6) The medicine has fast transdermal absorption speed, and can be applied for tens of minutes to produce obvious effect. Then wiping with towel or paper towel.
(7) For some people who may have skin allergy, skin tests can be performed on the back of the hand in advance.
(8) If the gel is found to be irritating to the skin, so that the skin is burning or itchy, even reddish, which may be caused by the medicament, it is only necessary to wash with water. Stopping the medicine immediately if red swelling or even blister occurs, and applying anti-inflammatory green ointment to prevent infection.
(9) For use by pregnant women, preferably under the direction of a physician.
Compared with the prior art, the invention has the beneficial effects that:
1. the compound Chinese herbal medicine gel for activating blood circulation achieves a remarkable effect of activating blood circulation by the mutual matching of different action mechanisms through the selection and content setting of the components, and can be used for relieving and treating various diseases.
2. The gel matrix of the compound Chinese herbal medicine gel for activating blood circulation has good compatibility with the traditional Chinese medicine components, the drug-loading rate is large, the gel is favorable for penetration and absorption on skin, the smearing is comfortable and convenient, and the irritation on skin is small.
3. The compound Chinese herbal medicine gel for activating blood circulation can be used as a medicine coupling agent for an ultrasonic therapeutic apparatus, and effectively combines two methods of physical treatment and medicine treatment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments, but the scope of the present invention is not limited to the embodiments.
The starting materials used in the following examples are all commercially available.
Example 1:
preparation of compound Chinese herbal medicine gel for activating blood circulation
S1, respectively weighing 500g of Chinese angelica, 300g of cinnamon, 50g of myrrh, 50g of frankincense, 300g of divaricate saposhnikovia root, 300g of szechuan lovage rhizome, 300g of salvia miltiorrhiza and 300g of dahurian angelica root, and sequentially performing alcohol extraction; the specific operation is that the alcohol solvent containing 75 percent of ethanol water solvent is added into the traditional Chinese medicine components to be refluxed twice, the first time is that the 10 times of solvent amount is refluxed for two hours, and the second time is that the 8 times of solvent amount is refluxed for one hour; refluxing at 80-100 deg.C, filtering, mixing the filtrates, cooling to 10-20 deg.C, standing for 2-8 hr for precipitation, and concentrating the clear liquid to specific gravity of 1.05-1.08 to obtain ethanol extractive solution;
s2, sequentially adding 200g of glycerol, 200g of propylene glycol, 2000g of water, 0g of laurocapram and 0g of parabens into 300g of sodium polyacrylate according to the formula amount, and stirring to obtain a gel-like water-soluble matrix;
and S3, uniformly stirring the alcohol extract obtained in the step S1 and the water-soluble matrix obtained in the step S2 to obtain the water-soluble organic fertilizer.
Example 2:
preparation of compound Chinese herbal medicine gel for activating blood circulation
S1, weighing 900g of Chinese angelica, 500g of cinnamon, 500g of myrrh, 500g of frankincense, 500g of divaricate saposhnikovia root, 500g of szechuan lovage rhizome, 500g of salvia miltiorrhiza and 500g of angelica dahurica respectively, and sequentially performing alcohol extraction; the specific operation is that the alcohol solvent containing 75 percent of ethanol water solvent is added into the traditional Chinese medicine components to be refluxed twice, the first time is that the 10 times of solvent amount is refluxed for two hours, and the second time is that the 8 times of solvent amount is refluxed for one hour; refluxing at 80-100 deg.C, filtering, mixing the filtrates, cooling to 10-20 deg.C, standing for 2-8 hr for precipitation, and concentrating the clear liquid to specific gravity of 1.05-1.08 to obtain ethanol extractive solution;
s2, sequentially adding 300g of glycerol, 300g of propylene glycol, 4000g of water, 200g of laurocapram and 50g of parabens into 600g of sodium polyacrylate according to the formula amount, and stirring to obtain a gel-like water-soluble matrix;
and S3, uniformly stirring the alcohol extract obtained in the step S1 and the water-soluble matrix obtained in the step S2 to obtain the water-soluble organic fertilizer.
Example 3:
preparation of compound Chinese herbal medicine gel for activating blood circulation
S1, weighing 900g of Chinese angelica, 500g of cinnamon, 500g of myrrh, 500g of frankincense, 500g of divaricate saposhnikovia root, 500g of szechuan lovage rhizome, 500g of asarum, 500g of biond magnolia flower, 500g of salvia miltiorrhiza and 500g of angelica dahurica, and sequentially carrying out alcohol extraction; the specific operation is that the alcohol solvent containing 75 percent of ethanol water solvent is added into the traditional Chinese medicine components to be refluxed twice, the first time is that the 10 times of solvent amount is refluxed for two hours, and the second time is that the 8 times of solvent amount is refluxed for one hour; refluxing at 80-100 deg.C, filtering, mixing the filtrates, cooling to 10-20 deg.C, standing for 2-8 hr for precipitation, and concentrating the clear liquid to specific gravity of 1.05-1.08 to obtain ethanol extractive solution; the alcohol of the components is soaked in 95 percent ethanol aqueous solution for 8 hours in advance;
s2, sequentially adding 300g of glycerol, 300g of propylene glycol, 4000g of water, 200g of laurocapram and 50g of parabens into 600g of sodium polyacrylate according to the formula amount, and stirring to obtain a gel-like water-soluble matrix;
and S3, uniformly stirring the alcohol extract obtained in the step S1 and the water-soluble matrix obtained in the step S2 to obtain the water-soluble organic fertilizer.
Example 4:
preparation of compound Chinese herbal medicine gel for activating blood circulation
S1, weighing 600g of Chinese angelica, 300g of cinnamon, 300g of myrrh, 300g of frankincense, 400g of divaricate saposhnikovia root, 400g of szechuan lovage rhizome, 200g of asarum, 200g of biond magnolia flower, 300g of salvia miltiorrhiza and 300g of angelica dahurica, and sequentially carrying out alcohol extraction; the specific operation is that the alcohol solvent containing 75 percent of ethanol water solvent is added into the traditional Chinese medicine components to be refluxed twice, the first time is that the 10 times of solvent amount is refluxed for two hours, and the second time is that the 8 times of solvent amount is refluxed for one hour; refluxing at 80-100 deg.C, filtering, mixing the filtrates, cooling to 10-20 deg.C, standing for 2-8 hr for precipitation, and concentrating the clear liquid to specific gravity of 1.05-1.08 to obtain ethanol extractive solution; the alcohol of the components is soaked in 95 percent ethanol water solvent for 6 hours in advance;
s2, sequentially adding 300g of glycerol, 300g of propylene glycol, 3500g of water, 100g of laurocapram and 30g of parabens into 450g of sodium polyacrylate according to the formula amount, and stirring to obtain a gel-like water-soluble matrix;
and S3, uniformly stirring the alcohol extract obtained in the step S1 and the water-soluble matrix obtained in the step S2 to obtain the water-soluble organic fertilizer.
Example 5:
preparation of compound Chinese herbal medicine gel for activating blood circulation
S1, weighing 800g of Chinese angelica, 500g of cinnamon, 400g of myrrh, 200g of frankincense, 500g of divaricate saposhnikovia root, 500g of szechuan lovage rhizome, 300g of asarum, 300g of biond magnolia flower, 400g of salvia miltiorrhiza and 400g of angelica dahurica, and sequentially carrying out alcohol extraction; the specific operation is that the alcohol solvent containing 75 percent of ethanol water solvent is added into the traditional Chinese medicine components to be refluxed twice, the first time is that the 10 times of solvent amount is refluxed for two hours, and the second time is that the 8 times of solvent amount is refluxed for one hour; refluxing at 80-100 deg.C, filtering, mixing the filtrates, cooling to 10-20 deg.C, standing for 2-8 hr for precipitation, and concentrating the clear liquid to specific gravity of 1.05-1.08 to obtain ethanol extractive solution; the alcohol of the components is soaked in 95 percent ethanol aqueous solution for 8 hours in advance;
s2, sequentially adding 200g of glycerol, 200g of propylene glycol, 3000g of water, 100g of laurocapram and 25g of parabens into 500g of sodium polyacrylate according to the formula amount, and stirring to obtain a gel-like water-soluble matrix;
and S3, uniformly stirring the alcohol extract obtained in the step S1 and the water-soluble matrix obtained in the step S2 to obtain the water-soluble organic fertilizer.
Performance testing
Example of clinical test
In order to evaluate the clinical curative effect and the safety of the medicine of the compound Chinese herbal medicine gel for promoting blood circulation, the invention respectively summarizes the curative effects on different diseases in practical clinical application for many years, and no toxic or side effect is found except that the gel can not be applied due to individual anaphylaxis.
Effect example 1-statistics of partial pain cases
In order to prove the treatment effect of the invention on pain cases, 140 acute and chronic patients, 88 male patients, 52 female patients, 18-70 years old, 8 acute patients and 112 chronic patients are clinically collected. 140 patients are divided into 7 groups, wherein 1-6 groups use the blood circulation promoting compound Chinese herbal medicine gel prepared in the embodiment 4 of the invention, and a control group adopts other commercially available or doctor-provided ointment.
[1] The medication method comprises the following steps: the gel preparation is applied to acute injury, and after chronic application, the gel preparation is applied by smearing, massaging and hot external application. The coating amount is about 3 g to 50g depending on the size of the lesion site and area, and the coating thickness is not more than 2 mm, and 1 mm is generally sufficient. The exposure therapy can be selected according to the treatment part, and the affected part can also be wrapped with gauze. The gel has sterilization function, so the treatment part does not need to be strictly cleaned and disinfected by using the gel. The application is carried out at least once every day, and can be carried out several times. The treatment course can be 3 days, 7 days, half a month or longer.
[2] Evaluation criteria:
[2] -1 recovery is pain disappearance without discomfort
[2] -2 is significantly reduced pain
[2] -3 ineffectiveness as pain unreduced
Calculating the total effective rate (healing case + obvious effect case)/total case
[3] The clinical effects are shown in Table 1
TABLE 1 curative effect of compound Chinese herbal medicine gel for activating blood circulation on pain cases
From the prescription of the compound Chinese herbal medicine gel for activating blood circulation, the theory of compatibility of traditional Chinese medicines is applied, for example, the compatibility of the ligusticum wallichii and the angelica can obviously inhibit the platelet aggregation and the formation of in-vitro thrombus of normal and blood stasis rats; the compatibility of Danshen root with Chuan Xiong is a necessary and scientific theory for the mutual reinforcement of TCM. The herbs have no effect on the detumescence of sports injury and promoting blood circulation. The formation of swelling is due to the disturbance of the normal flow of blood, which is sometimes required by the body water, otherwise the water which is not removed is accumulated to form edema. When the blood flow is normal, the swelling disappears naturally. It should be noted that the flow of blood to carry the edematous water away is not a simple process involving blood pressure, the osmotic function of the vascular and lymphatic membranes, that is modern biology rather than the traditional chinese medicine thinking.
The test group 1 is in the pain category, mild sports injuries are mainly basketball, football and track and field sports, when the foot of a Brazilian football team is sprained and swollen, the shoes can not be worn, and the shoes can be worn half an hour after the blood activating compound Chinese herbal medicine gel is immediately smeared.
The acute cervical spondylitis of the test group 2 is mostly a stiff neck case, the neck is twisted after waking up, and the patient can be rubbed with the blood circulation-promoting compound Chinese herbal medicine gel for later use at this time, and is gently rubbed along the muscle, so that the pain is obviously relieved, and the patient can be cured by rubbing for a few times for mild symptoms.
The test group 3 had chronic scapulohumeral periarthritis, many of which were occupational diseases, and the doctors in the B-ultrasonic room of the hospital performed hand-held probe scans, and the teacher in the podium and the barber performed long-term fatigue on the shoulder muscles of the handles. Some doctors do physical therapy ineffectiveness for half a month in hospitals, and the compound traditional Chinese medicine gel for activating blood circulation is used for smearing for several times to achieve effect and is cured slowly.
The joint pain of legs in the test group 4 is mostly joint strain, especially the waist and leg pain of the old.
Dysmenorrhea of women in test group 5 is mostly weak in young women.
In test group 6, patients with periodontitis only need to apply the compound traditional Chinese medicine gel for activating blood circulation a little more on the skin of the teeth at the chin, and the pain can be relieved within minutes in a short time and half an hour in a short time. In most cases, the deficient fire rises, and the problem can be solved by taking calculus bovis detoxification tablets or Zhongkang anti-inflammatory pills in traditional Chinese medicine.
As can be seen from the table 1, the compound Chinese herbal medicine gel for activating blood circulation disclosed by the invention can relieve pain in a short time, has the effective rate of over 90%, and has obvious effects on sports injury, acute cervical spondylitis, scapulohumeral periarthritis, arthralgia, periodontitis and female dysmenorrhea. Therefore, the compound Chinese herbal medicine gel for promoting blood circulation has reasonable formula, treats both principal and secondary aspects of diseases, and has the effects of promoting blood circulation to remove blood stasis, and relieving swelling and pain.
Effect example 2-Individual case situation Table
The treatment reports of individual cases using the blood-activating compound Chinese herbal medicine gel of the invention are collected below, and the results are shown in table 2.
TABLE 2
The symptoms collected in table 2 have significant effects on limb injuries, chronic rhinitis, dysmenorrhea and scalding in particular. The compound Chinese herbal medicine gel for activating blood circulation is applied to treating radioactive ray burn for the first time, achieves breakthrough progress, and shows the precious value of the traditional Chinese medicine.
Effect example 3-clinical report of TCM institute in Wengyuan county
The compound Chinese herbal medicine gel for promoting blood circulation provided by the invention is cooperated with Wengyuan county Chinese medicine institute, and relevant clinical applications are carried out. The traditional Chinese medicine mud cream is the name of the initial test product of the compound Chinese herbal medicine gel in clinic. The clinical report content is provided by the institute of medicine in Wengyuan county.
Clinical application cooperation of traditional Chinese medicine mud ointment fomentation for treating scapulohumeral periarthritis is carried out by a traditional Chinese medicine mud ointment fomentation unit in the Wengyuan county in Shaoguan city in 2015, and the project obtains three prizes of technological progress of local government. The traditional Chinese medicine mud cream in the report is a compound Chinese herbal medicine gel for promoting blood circulation, and the traditional Chinese medicine preparation named as "blood-activating mud cream" is adopted by the traditional Chinese medicine institute in Wengyuan county and is matched with the traditional massage method to treat acute lumbar sprain, so that the ideal results of simple method, remarkable curative effect and shortened course of disease are obtained.
1 clinical data
The typical cases are from inpatients and outpatients in the rehabilitation department, and are both acute lumbar sprain.
In case of 12 months in 12015 years, a woman in Pan and a person in 45 years old are in charge of a public security officer in a county, and the waist is carelessly strained when the person is mopped at home, so that tendons and vessels are damaged, the right side waist and back are severely painful, the person is difficult to turn over and turn around, the waist is limited in activity, and the person is reluctant to stand and walk.
In the case of 22016 years, 2 months, Zhangzhi, male and 35 years old, the waist is strained for 1 day carelessly due to heavy object removal, so that the right waist is difficult to endure, the patient cannot stand up to go straight and go straight, and the pain is aggravated when the patient coughs and turns sideways. And (4) checking: the pain is expressed and the dysphoria is not smooth, the pain is obvious and the pain is aggravated when the patient is coughed, and the pain is not detected in the 4-5 character experiment; a thin and white tongue coating and a wiry and tense pulse.
2 method of treatment
(1) Basic manipulations:
(1.1) standing the patient in the prone position, applying a proper amount of blood circulation promoting mud cream to the waist and the back, uniformly applying the blood circulation promoting mud cream to the waist and the back with the palms of the two hands, walking along the bladder to the back to the hip, and repeatedly performing the operation for 3 minutes.
(1.2) carry out continuous pressing from the top to the bottom along Huatuo Qianjiao Yao 1-sacral 1 points on both sides of the patient's lumbar vertebra with the thumb, and do not apply strong manipulations on the pain points, which should be done for 2 minutes.
(1.3) apply appropriate amount of Huoxue mud ointment on both sides of the psoas muscle, conduct Rou on both sides of the psoas muscle of the patient with multi-fingers, conduct operation on the tense part of the psoas muscle with emphasis on the operation, conduct operation repeatedly for 3 minutes.
(1.4) carry out an-rou with the thumb of the two hands on Shenshu, Dachangshu, Yangguan, Ganshu, Venezhong, Juliao, Huatiao, Chengjin, Yanglingquan, sprain, plantar lumbar pain and points thereon for about 1 minute.
(1.5) after all the massage manipulations are finished, uniformly coating a layer of blood circulation promoting mud ointment on the pain points and the periphery, and then irradiating the affected part by using an infrared therapeutic apparatus to facilitate absorption.
3 therapeutic principles
Acute lumbar sprain is usually caused by the strenuous rotation of the body and the imbalance of the muscle strength of the waist. The injury usually occurs in the adhesion part of the acanthomys spinatus and the fascia on the back, and the soft tissue injury leads to the local insufficiency of qi and blood oxygen supply, the blockage of channels and collaterals and the unsmooth circulation of qi and blood. Dredge meridians, promote the circulation of qi and blood, and promote blood circulation to remove blood stasis.
4 therapeutic results
Typical case 1: the patient feels pain (1/3 is removed) after performing point-and-rou on points of Weizhong, Shenshu, Yanglingquan and the like with the thumb, and the pain is relieved when the blood activating mud cream is dried and absorbed thoroughly, the waist of the patient moves freely and the pain is relieved obviously when the patient walks.
Typical case 2: the symptoms belong to traumatic meridian and unsmooth collaterals, and the treatment is suitable for relaxing muscles and tendons, promoting blood circulation, clearing and activating the channels and collaterals and relieving pain. When the patient moves the blood activating mud cream to stir and rub the two sides of the lumbar muscle, the pain is relieved, and after the operation is finished for 30 minutes, the waist of the patient moves freely without obvious pain.
To summarize:
for acute lumbar sprain, the symptoms are local stagnation of qi and blood, meridian obstruction, muscle damage, pain in the waist, and over-heavy massage manipulations, which tend to aggravate local muscle tension. So the manipulation should be mild and combined with Huoxue mud paste to regulate qi movement and dredge qi and blood. For example, the book Sheng Ji Zong & Shang Bimen says: "if the channels and collaterals are disturbed and moved internally, the blood circulation can not be smooth and stasis can not be dispersed, the swelling is pain, and the treatment aims at removing stasis and promoting the circulation of qi and blood; the mud cream for promoting blood circulation contains extractive solutions of radix Angelicae sinensis, Myrrha, Olibanum, radix Saposhnikoviae, rhizoma Ligustici Chuanxiong, cortex Cinnamomi, and Saviae Miltiorrhizae radix. Has effects of dredging channels and collaterals, promoting blood circulation, removing blood stasis, relieving swelling and pain, etc. According to clinical application observation of the rehabilitation department on patients with acute lumbar sprain, the ointment has obvious effects of relieving swelling, dissipating blood stasis and relieving pain.
Variations and modifications to the above-described embodiments may occur to those skilled in the art, which fall within the scope and spirit of the above description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and variations of the present invention should fall within the scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.
Claims (10)
1. The compound Chinese herbal medicine gel for activating blood circulation is characterized by being prepared from the following raw material medicines in parts by mass: 900 parts of 500-materials of angelica, 500 parts of 300-materials of cinnamon, 0-500 parts of myrrh, 0-500 parts of frankincense, 500 parts of divaricate saposhnikovia root, 500 parts of szechuan lovage rhizome, 500 parts of 300-materials of salvia miltiorrhiza, 500 parts of 300-materials of angelica and 5500 parts of 3000-materials of water-soluble gel matrix;
the water-soluble gel matrix is prepared from the following raw material medicines in parts by mass: 600 portions of polyacrylate 300-.
2. The compound Chinese herbal medicine gel for activating blood circulation according to claim 1, which is characterized by being prepared from the following raw material medicines in parts by mass: 900 parts of 500-materials of angelica, 500 parts of 300-materials of cinnamon, 0-500 parts of myrrh, 0-500 parts of frankincense, 500 parts of divaricate saposhnikovia root, 500 parts of szechuan lovage rhizome, 0-500 parts of asarum, 0-500 parts of magnolia flower, 500 parts of 300-materials of salvia, 500 parts of 300-materials of angelica and 5500 parts of 3000-materials of water-soluble gel matrix.
3. The compound Chinese herbal medicine gel for activating blood circulation according to claim 1 or 2, which is characterized by being prepared from the following raw material medicines in parts by mass: 800 portions of 600-containing angelica, 500 portions of 300-containing cinnamon, 400 portions of 300-containing myrrh, 300 portions of frankincense, 500 portions of 400-containing divaricate saposhnikovia root, 500 portions of 400-containing ligusticum wallichii, 300 portions of 100-containing asarum, 300 portions of magnolia flower, 400 portions of 300-containing salvia miltiorrhiza, 400 portions of 300-containing angelica and 5000 portions of 4000-containing water-soluble gel matrix.
4. The compound Chinese herbal medicine gel for activating blood circulation according to claim 1, characterized in that the water-soluble gel matrix is prepared from the following raw material medicines in parts by mass: 400-500 parts of sodium polyacrylate, 200-300 parts of glycerol, 200-300 parts of propylene glycol, 200-200 parts of laurocapram, 3000-4000 parts of water and 25-50 parts of parabens.
5. The compound Chinese herbal medicine gel for activating blood circulation according to claim 2, which is characterized by being prepared from the following raw material medicines in parts by mass: 600 parts of angelica sinensis, 300 parts of cinnamon, 300 parts of myrrh, 300 parts of frankincense, 400 parts of divaricate saposhnikovia root, 400 parts of ligusticum wallichii, 200 parts of asarum, 200 parts of biond magnolia flower, 300 parts of salvia miltiorrhiza, 300 parts of radix angelicae and 4500 parts of water-soluble gel matrix; the water-soluble gel matrix is prepared from the following raw material medicines in parts by mass: 450 parts of sodium polyacrylate, 300 parts of glycerol, 300 parts of propylene glycol, 100 parts of laurocapram, 3500 parts of water and 30 parts of parabens.
6. The preparation method of the compound Chinese herbal medicine gel for activating blood circulation as claimed in claim 1, which is characterized by comprising the following steps:
s1, sequentially carrying out alcohol extraction on Chinese medicinal components including Chinese angelica, cinnamon, myrrh, frankincense, divaricate saposhnikovia root, szechuan lovage rhizome, salvia miltiorrhiza and dahurian angelica root, wherein an alcohol extraction solvent is an aqueous solvent containing 75% of alcohol; the specific operation is that the alcohol extraction solvent is added into the traditional Chinese medicine components to reflux twice, the first time is that the solvent amount which is 10 times that of the traditional Chinese medicine components reflux for two hours, and the second time is that the solvent amount which is 8 times that of the traditional Chinese medicine components reflux for one hour; refluxing at 80-100 deg.C, filtering, mixing the filtrates, cooling to 10-20 deg.C, standing for 2-8 hr for precipitation, and concentrating the clear liquid to specific gravity of 1.05-1.08 to obtain ethanol extractive solution; preferably, the traditional Chinese medicine component alcohol is soaked in 95 percent ethanol aqueous solution for 3 to 8 hours in advance;
s2, sequentially adding glycerol, propylene glycol, water, laurocapram and parabens into polyacrylate according to the formula amount, and stirring to form a gel-like water-soluble matrix;
and S3, uniformly stirring the alcohol extract obtained in the step S1 and the water-soluble matrix obtained in the step S2 to obtain the water-soluble organic fertilizer.
7. The preparation method of the blood-activating compound Chinese herbal medicine gel as claimed in claim 6, wherein the propylene glycol in S2 is partially or completely added into the alcohol-extracted solvent containing 75% ethanol water solvent in S1, and the reflux temperature is raised to above 120 ℃.
8. The compound Chinese herbal medicine gel for activating blood circulation according to any one of claims 1 to 5, which is used for preparing a product for treating diseases caused by blood circulation disorder, wherein the diseases caused by blood circulation disorder comprise traumatic injury, cervical spondylosis, scapulohumeral periarthritis, hyperosteogeny, periodontitis, otorrhitis, female dysmenorrhea, male prostatitis, gout and headache; nasal obstruction, chronic rhinitis and allergic rhinitis due to common cold; chest oppression and palpitation.
9. The use method of the compound Chinese herbal medicine gel for activating blood circulation as claimed in any one of claims 1 to 5, is characterized by comprising the following steps:
(1) applied to the external surface of the patient's skin;
(2) applying on affected part, and massaging pain point, channels and collaterals or acupuncture point;
(3) the foment package method can be adopted for treating scapulohumeral periarthritis;
(4) applied to the affected part, and absorbed by ultrasonic therapeutic apparatus.
10. The compound Chinese herbal medicine gel for activating blood circulation of any one of claims 1 to 5 is used as a medical ultrasonic coupling agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010825376.1A CN111904997A (en) | 2020-08-17 | 2020-08-17 | Compound Chinese herbal medicine gel for promoting blood circulation and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010825376.1A CN111904997A (en) | 2020-08-17 | 2020-08-17 | Compound Chinese herbal medicine gel for promoting blood circulation and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111904997A true CN111904997A (en) | 2020-11-10 |
Family
ID=73278226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010825376.1A Pending CN111904997A (en) | 2020-08-17 | 2020-08-17 | Compound Chinese herbal medicine gel for promoting blood circulation and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111904997A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640441A (en) * | 2004-01-10 | 2005-07-20 | 贾曦 | Embrocation for treating allergic rhinitis |
| CN101357161A (en) * | 2008-08-22 | 2009-02-04 | 江红旗 | External medicine for treating vascular headache and preparation method thereof |
| CN101972466A (en) * | 2010-11-10 | 2011-02-16 | 罗文礼 | Traditional Chinese medicine cataplasm capable of rapidly relieving pain of dysmenorrhea and regulating menstruation and preparation method thereof |
-
2020
- 2020-08-17 CN CN202010825376.1A patent/CN111904997A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640441A (en) * | 2004-01-10 | 2005-07-20 | 贾曦 | Embrocation for treating allergic rhinitis |
| CN101357161A (en) * | 2008-08-22 | 2009-02-04 | 江红旗 | External medicine for treating vascular headache and preparation method thereof |
| CN101972466A (en) * | 2010-11-10 | 2011-02-16 | 罗文礼 | Traditional Chinese medicine cataplasm capable of rapidly relieving pain of dysmenorrhea and regulating menstruation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 韦礼贵: "自制药膏隔姜灸治疗腰腿痛100例", 《广西中医药》 * |
| 马涛等: "直流中药离子导入与电针联合治疗膝关节骨性关节炎的临床疗效观察", 《世界最新医学信息文摘》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101167847B (en) | Traditional Chinese medicinal white spirit preparation for effectively treating skin disease | |
| CN101066303B (en) | Medicine for treating cerebral thrombus, cerebral angiosclerosis, apoplexy and hemiplegia and its preparation | |
| CN101810685B (en) | Chinese medicinal composition for treating gonitis and preparation method thereof | |
| CN102697899A (en) | Traditional Chinese medicine composition for treating osteoarthritis and preparation method thereof | |
| CN102526406B (en) | Traditional Chinese medicine plaster for treating cervical spondylotic radiculopathy and preparation method thereof | |
| CN102274252B (en) | Stauntonvine external applied preparation for treating rheumatoid diseases and preparation method thereof | |
| CN104258278A (en) | Gushangling (for bone injury) spray | |
| CN101164610A (en) | Blood-circulation and removing blood stasis ointment | |
| CN102949680B (en) | Medicinal liquor for treating cervical spondylosis and preparation method thereof | |
| CN1733167A (en) | External applied Chinese traditional medicine plaster for curing facial paralysis and process for preparing the same | |
| CN111904997A (en) | Compound Chinese herbal medicine gel for promoting blood circulation and preparation method and application thereof | |
| CN102961561B (en) | Chinese medicinal composition for treating coronary heart disease | |
| CN109731047A (en) | It is a kind of to treat disc herniation, osteoproliferation, rheumatism numbness pain, the arthralgia and myalgia cream of neck-shoulder pain, lumbago and leg pain and preparation method | |
| CN102028810B (en) | Traditional Chinese medicine for treating lumbar intervertebral disc protrusion | |
| CN101904922B (en) | Plaster for treating pain caused by femoral head necrosis | |
| CN101322787B (en) | Specific medicinal liquor for treating rheumatoild disease | |
| CN101897764A (en) | Chinese medicinal preparation for treating sciatica | |
| CN107281444B (en) | Analgesic pharmaceutical composition and preparation method and application thereof | |
| CN105106786A (en) | Traditional Chinese medicine composition capable of dredging collaterals and relaxing muscles as well as preparation and production method of composition | |
| CN105560537A (en) | Medicine composition for treating osteoartritis and preparation method thereof | |
| CN105055753A (en) | Hemorrhoid ointment and preparation process thereof | |
| CN103212049A (en) | Medicament for treating Raynaud syndrome | |
| CN105381098A (en) | Traditional Chinese medicine fumigating and washing agent for treating knee osteoarthritis and nursing method | |
| CN1321658C (en) | Ointment for activating blood circulation to dissipate blood stasis | |
| CN103948679A (en) | External application for treating wind-cold-dampness arthritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201110 |