CN105213973A - For alleviating the pharmaceutical composition of symptom before feminine menstrual - Google Patents
For alleviating the pharmaceutical composition of symptom before feminine menstrual Download PDFInfo
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Abstract
The present invention relates to a kind of pharmaceutical composition for alleviating symptom before feminine menstrual, it is prepared by following raw material and obtains: Radix Bupleuri, Fructus Aurantii, Cortex Albiziae, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Fructus Liquidambaris, Semen Citri Reticulatae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Poria, Pericarpium Arecae, Radix Glycyrrhizae.Medicine treating both the principal and secondary aspects of a disease of the present invention, evident in efficacy, there is good therapeutic effect to premenstrual tension syndrome, have a extensive future.
Description
Technical field
The invention belongs to Chinese medicine field, being specifically related to a kind of pharmaceutical composition for alleviating symptom before feminine menstrual.
Background technology
, also known as premenstrual tension syndrome, there is symptom in premenstrual 7-14 days, day by day increase the weight of in pre-menstrual period nercousness, until after menstruation, symptom fades away, and comparatively severe one can continue more of a specified duration.Clinical main manifestations is that premenstruum is excited, and irritable is depressed, depressed sad, distending pain of the breast, distending pain in the chest and hypochondrium, lower abdominal pain or headache, or has edema in various degree, more or less mensis in amount, and color is dark, dark tongue quality, stringy pulse etc.Differential diagnosis in tcm mainly belongs to stagnation of QI due to depression of the liver, uses liver-smoothing, qi-regulating, and HuoXueTongLuo oral Liquor is treated, and how can prove effective.According to investigations: about have the women that passes through of 50% to suffer from this disease, be commonly encountered diseases, frequently-occurring disease, all have larger impact to work and life.External portion investigation material shows: 107 incidence rates of protecting school student are 80%; The incidence rate of 1000 all kinds of women is separately had to be 95%; Domestic have the investigation of report 2000 example, and sickness rate is 42%.20-30 year give birth to vigorous women to suffer from this disease person maximum, 20-30 person's sickness rate is 38%, 30-40 years old person's sickness rate be 29%, 40-50 years old person's sickness rate is 33%.Its main manifestations of premenstrual tension syndrome has irritable, insomnia, anxiety, constrains and a series of symptom such as headache, distending pain of the breast, facial edema, and severe patient can affect the orthobiosis of women.From the clinical symptoms of premenstrual tension syndrome, this disease is one of disease that women of child-bearing age's sickness rate is higher.Meanwhile, premenstrual tension syndrome is a kind of female diseases that the composite factor such as a kind of physiology and social mentality causes.The at present definition of serious premenstrual tension syndrome premenstrual symptom is also inconsistent.But in nearest research, this diagnostic criteria obtains unified substantially, and for diagnosing this series of serious premenstrual symptom (dysphoria mental disorder premenstruum) with multiple performance---based at least 5 kinds of symptoms, comprise one of 4 kinds of core mental symptoms simultaneously and (go out the form of self-contained 17 kinds of physiology, mental symptoms.These 17 kinds of symptoms are: depressed, helpless and sense of guilt, anxiety/pressure are large, emotional lability, irritability/continue indignation, interest reduces, absent minded, tired, bulimia, sleep disorder, without autocontrol force or vulnerable, assist ability, headache, pain, edema/body weight increase, tic, distending pain of the breast) and to increase the weight of in premenstruum, alleviate after menstruation or disappearance etc.
Current, western medical treatment, because the true cause of falling ill to pre-menstrual period nercousness is unclear, therefore takes symptomatic treatment more, psychology or psychotherapy, corrects the method such as salt and water imbalance, unsatisfactory curative effect.Chinese medicine has advantage, therefore sums up China's successive dynasties Couple herbs, and the new drug of active development treatment primary disease has important value.
Without premenstrual tension syndrome name of disease in China's traditional medicine, but just like the discussion of " premenstrual heating ", " premenstrual agitation " etc.This type of symptom is often referred to as " before and after menstruation all cards " by modern Chinese medicine gynecological.Its clinical manifestation symptom is numerous, complicated, as headache during menstruation, generates heat, tells nosebleed, erosion of the oral mucosa, edema, cough with asthma, abnormal emotion-thought etc.Though for another through after removing water retention by purgation, tic, singultus, bluish lip, swelling, the less generations such as disease of itching, have finding at ancient books and modern clinic.According to ancients' understanding in conjunction with modern clinic reality, think that why all cards are with menstrual cycle outbreak before and after menstruation at present, be full of empty to change and body constitution has substantial connection with QI and blood in menstrual period.Chinese medicine has advantage, therefore sums up China's successive dynasties Couple herbs, and the new drug of active development treatment primary disease has important value.
Summary of the invention
The object of this invention is to provide a kind for the treatment of both the principal and secondary aspects of a disease, have no side effect, safe ready, cheap pure traditional Chinese compound medicine.
Motherland's medical science is thought, regulating menstruation should focus on and regulate the flow of vital energy, and holds up spleen, and the kidney invigorating is soothing the liver, and the traditional Chinese medical science focuses on regulating menstruation to effect a permanent cure, and depressed liver-energy dispersing and QI regulating, clearing away heat and cooling blood, invigorating the spleen and benefiting QI, make irritability Shu Da, and menses are smooth.Current, western medical treatment premenstrual syndrome is taked to correct the method such as salt and water imbalance, unsatisfactory curative effect more.Chinese medical theory then thinks depression of liver-QI, and the liver failing to maintain the normal flow of QI, qi depression to blood stasis is the main pathogenesis characteristics of pre-menstrual period nercousness.Pharmaceutical composition of the present invention is cut out by eternal recipe XIAOYAO POWDER and bupleurum powder for relieving liver-qiization, is the classical medication for the treatment of by Chinese herbs premenstrual syndrome, can liver-smoothing, qi-regulating, promoting blood circulation to remove obstruction in the collateral.Present inventor puts into practice according to doctor's row for many years in conjunction with forefathers' secret recipe, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, from motherland's medical treasure-house, filter out the yin fluid astringing that nourishes blood, depressed liver-energy dispersing and QI regulating, the natural Chinese medicine of invigorating the spleen and benefiting QI, by theory of Chinese medical science prescription, skims the cream off milk, meticulously be mixed with the Chinese medicine composition of conditioning feminine menstrual PMS of the present invention in conjunction with Traditional Chinese Medicine technology, premenstrual syndrome had to effect of rapid healing.
For achieving the above object, the technical solution used in the present invention is as follows:
For alleviating a pharmaceutical composition for symptom before feminine menstrual, it is prepared by following raw material and obtains:
Radix Bupleuri, Fructus Aurantii, Cortex Albiziae, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Fructus Liquidambaris, Semen Citri Reticulatae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Poria, Pericarpium Arecae, Radix Glycyrrhizae.
Preferably, it is prepared by the raw material of following weight proportioning and obtains:
Radix Bupleuri 400g, Fructus Aurantii 400g, Cortex Albiziae 320g, Radix Curcumae 320g, Rhizoma Cyperi 320g,
Pericarpium Citri Reticulatae Viride 240g, Fructus Liquidambaris 280g, Semen Citri Reticulatae 240g, Radix Angelicae Sinensis 320g, Radix Paeoniae Alba 320g,
Rhizoma Chuanxiong 240g, Poria 240g, Pericarpium Arecae 240g, Radix Glycyrrhizae 120g.
Described pharmaceutical composition preparation method is:
Above-mentioned raw materials medicine is taken for subsequent use according to above-mentioned weight:
(1) get Radix Bupleuri, Fructus Aurantii, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, the Rhizoma Chuanxiong way of distillation extract volatile oil; volatile oil beta cyclodextrin makes clathrate A; the volume ratio of volatile oil and beta cyclodextrin is 1:6; medicinal residues after distillation add 8 times of weight water and decoct 2 times; 1 hour first time; half an hour for the second time, merge decoction liquor, obtain liquid B;
(2) Cortex Albiziae is got, Fructus Liquidambaris, Semen Citri Reticulatae, the Radix Paeoniae Alba, Poria, Pericarpium Arecae, Radix Glycyrrhizae decocts with water twice, first time adds the soak by water 2 hours of 10 times of weight, second time adds 8 times of weight water and decocts 1 hour, merge twice decoction liquor, obtain liquid C, liquid B and liquid C are mixed, concentrating under reduced pressure obtains the thick paste (75 DEG C) that density is 1.20-1.25g/ml, ethanol is added after cooling, ethanol content is made to be 55%(volume fraction), leave standstill 24 hours, filter, precipitate with 55% washing with alcohol (volume fraction), filter, merging filtrate, reclaim ethanol, concentrating under reduced pressure obtains the thick paste (75 DEG C) that density is 1.20-1.25g/ml, spraying dry, obtain mixture D,
(3) mixture D mixing prepared by clathrate A step 1 prepared and step 2, add adjuvant carboxymethyl starch, magnesium stearate, mixing, is pressed into 1000, film coating, obtains final product.
Again preferably, the present invention is for alleviating the pharmaceutical composition of symptom before feminine menstrual, and it is prepared by following raw material and obtains:
Radix Bupleuri, Fructus Aurantii, Cortex Albiziae, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Fructus Liquidambaris, Semen Citri Reticulatae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Poria, Pericarpium Arecae, Radix Glycyrrhizae, Pollen Typhae, Radix Paeoniae Rubra, the Flos Sophorae Immaturus, Fructus Foeniculi, Rhizoma Dioscoreae, Semen Coicis, geranium, the Radix Angelicae Dahuricae, Radix Notoginseng, Myrrha, Rhizoma Curcumae Longae, Cortex Magnoliae Officinalis, Fructus Psoraleae, Cortex Moutan, Olibanum.
Preferably, it is prepared by the raw material of following weight proportioning and obtains:
Radix Bupleuri 400g, Fructus Aurantii 400g, Cortex Albiziae 320g, Radix Curcumae 320g, Rhizoma Cyperi 320g,
Pericarpium Citri Reticulatae Viride 240g, Fructus Liquidambaris 280g, Semen Citri Reticulatae 240g, Radix Angelicae Sinensis 320g, Radix Paeoniae Alba 320g,
Rhizoma Chuanxiong 240g, Poria 240g, Pericarpium Arecae 240g, Radix Glycyrrhizae 120g, Pollen Typhae 120g,
Radix Paeoniae Rubra 100g, Flos Sophorae Immaturus 80g, Fructus Foeniculi 80g, Rhizoma Dioscoreae 80g, Semen Coicis 50g,
Geranium 50g, Radix Angelicae Dahuricae 50g, Radix Notoginseng 50g, Myrrha 50g, Rhizoma Curcumae Longae 50g,
Cortex Magnoliae Officinalis 30g, Fructus Psoraleae 30g, Cortex Moutan 20g, Olibanum 20g.
Described pharmaceutical composition preparation method is:
Above-mentioned raw materials medicine is taken for subsequent use according to above-mentioned weight:
(1) get Radix Bupleuri, Fructus Aurantii, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, the Rhizoma Chuanxiong way of distillation extract volatile oil; volatile oil beta cyclodextrin makes clathrate A; the volume ratio of volatile oil and beta cyclodextrin is 1:6; medicinal residues after distillation add 8 times of weight water and decoct 2 times; 1 hour first time; half an hour for the second time, merge decoction liquor, obtain liquid B;
(2) Cortex Albiziae is got, Fructus Liquidambaris, Semen Citri Reticulatae, the Radix Paeoniae Alba, Poria, Pericarpium Arecae, Radix Glycyrrhizae decocts with water twice, first time adds the soak by water 2 hours of 10 times of weight, second time adds 8 times of weight water and decocts 1 hour, merge twice decoction liquor, obtain liquid C, liquid B and liquid C are mixed, concentrating under reduced pressure obtains the thick paste (75 DEG C) that density is 1.20-1.25g/ml, ethanol is added after cooling, ethanol content is made to be 55%(volume fraction), leave standstill 24 hours, filter, precipitate with 55% washing with alcohol (volume fraction), filter, merging filtrate, reclaim ethanol, concentrating under reduced pressure obtains the thick paste (75 DEG C) that density is 1.20-1.25g/ml, spraying dry, obtain mixture D,
(3) get Pollen Typhae, Radix Paeoniae Rubra, the Flos Sophorae Immaturus, Fructus Foeniculi, Rhizoma Dioscoreae, Semen Coicis, geranium, the Radix Angelicae Dahuricae, Radix Notoginseng, Myrrha, Rhizoma Curcumae Longae, Cortex Magnoliae Officinalis, Fructus Psoraleae, Cortex Moutan, Olibanum add ethanol relative to mixture 3 times of weight 95%, reflux, extract, 2 times, each 2 hours, filtrate merges, be concentrated into the thick paste that density is 1.25g/ml, 80 DEG C of oven dry, are ground into powder, are complex E;
(4) complex E prepared by mixture D step 3 prepared by clathrate A step 1 prepared and step 2 mixes, and adds adjuvant carboxymethyl starch, magnesium stearate, and mixing, is pressed into 1000, film coating, obtains final product.
Function cures mainly: the effects such as dispersing the stagnated live-QI to relieve the stagnation of QI, regulating QI to relieve pain, nourishing blood for regulating menstruation, for premenstrual tension syndrome and primary dysmenorrhea, premenstruum, distending pain of the breast, had significant curative effect through carrying out lower abdomen pain, Chinese medicine preparation provided by the invention is clinical does not simultaneously find untoward reaction, and drug safety is reliable.Each 1, three times on the one.
The component of medicine of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, and medicine source is extensive, and with low cost, it follows the prescriptions principle of the traditional Chinese medical science, and through clinical practice checking, it is reliably evident in efficacy, mild in medicine property and, there is not toxic and side effects, have a extensive future.
Detailed description of the invention
Embodiment 1
For alleviating a pharmaceutical composition for symptom before feminine menstrual, it is prepared by the raw material of following weight proportioning and obtains:
Radix Bupleuri 400g, Fructus Aurantii 400g, Cortex Albiziae 320g, Radix Curcumae 320g, Rhizoma Cyperi 320g,
Pericarpium Citri Reticulatae Viride 240g, Fructus Liquidambaris 280g, Semen Citri Reticulatae 240g, Radix Angelicae Sinensis 320g, Radix Paeoniae Alba 320g,
Rhizoma Chuanxiong 240g, Poria 240g, Pericarpium Arecae 240g, Radix Glycyrrhizae 120g.
Described pharmaceutical composition preparation method is:
Above-mentioned raw materials medicine is taken for subsequent use according to above-mentioned weight:
(1) get Radix Bupleuri, Fructus Aurantii, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, the Rhizoma Chuanxiong way of distillation extract volatile oil; volatile oil beta cyclodextrin makes clathrate A; volatile oil: beta cyclodextrin=1:6(volume ratio); 40 DEG C of inclusions, stir 1 hour, get the medicinal residues after distillation and add 8 times of weight water and decoct 2 times; 1 hour first time; half an hour for the second time, merge decoction liquor, obtain liquid B;
(2) Cortex Albiziae is got, Fructus Liquidambaris, Semen Citri Reticulatae, the Radix Paeoniae Alba, Poria, Pericarpium Arecae, Radix Glycyrrhizae decocts with water twice, first time adds the soak by water 2 hours of 10 times of weight, second time adds 8 times of weight water and decocts 1 hour, merge twice decoction liquor, obtain liquid C, liquid B and liquid C are mixed, concentrating under reduced pressure obtains the thick paste (75 DEG C) that density is 1.20-1.25g/ml, ethanol is added after cooling, ethanol content is made to be 55%(volume fraction), leave standstill 24 hours, filter, precipitate with 55% washing with alcohol (volume fraction), filter, merging filtrate, reclaim ethanol, concentrating under reduced pressure obtains the thick paste (75 DEG C) that density is 1.20-1.25g/ml, spraying dry, obtain mixture D,
(3) mixture D mixing prepared by clathrate A step 1 prepared and step 2, add adjuvant carboxymethyl starch, magnesium stearate, mixing, is pressed into 1000, film coating, obtains final product.
Embodiment 2
For alleviating the pharmaceutical composition of symptom before feminine menstrual, it is prepared by the raw material of following weight proportioning and obtains:
Radix Bupleuri 400g, Fructus Aurantii 400g, Cortex Albiziae 320g, Radix Curcumae 320g, Rhizoma Cyperi 320g,
Pericarpium Citri Reticulatae Viride 240g, Fructus Liquidambaris 280g, Semen Citri Reticulatae 240g, Radix Angelicae Sinensis 320g, Radix Paeoniae Alba 320g,
Rhizoma Chuanxiong 240g, Poria 240g, Pericarpium Arecae 240g, Radix Glycyrrhizae 120g, Pollen Typhae 120g,
Radix Paeoniae Rubra 100g, Flos Sophorae Immaturus 80g, Fructus Foeniculi 80g, Rhizoma Dioscoreae 80g, Semen Coicis 50g,
Geranium 50g, Radix Angelicae Dahuricae 50g, Radix Notoginseng 50g, Myrrha 50g, Rhizoma Curcumae Longae 50g,
Cortex Magnoliae Officinalis 30g, Fructus Psoraleae 30g, Cortex Moutan 20g, Olibanum 20g.
Described pharmaceutical composition preparation method is:
Above-mentioned raw materials medicine is taken for subsequent use according to above-mentioned weight:
(1) get Radix Bupleuri, Fructus Aurantii, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, the Rhizoma Chuanxiong way of distillation extract volatile oil; volatile oil beta cyclodextrin makes clathrate A; volatile oil: beta cyclodextrin=1:6(volume ratio); 40 DEG C of inclusions, stir 1 hour, and the medicinal residues after distillation add 8 times of weight water and decoct 2 times; 1 hour first time; half an hour for the second time, merge decoction liquor, obtain liquid B;
(2) Cortex Albiziae is got, Fructus Liquidambaris, Semen Citri Reticulatae, the Radix Paeoniae Alba, Poria, Pericarpium Arecae, Radix Glycyrrhizae decocts with water twice, first time adds the soak by water 2 hours of 10 times of weight, second time adds 8 times of weight water and decocts 1 hour, merge twice decoction liquor, obtain liquid C, liquid B and liquid C are mixed, concentrating under reduced pressure obtains the thick paste (75 DEG C) that density is 1.20-1.25g/ml, ethanol is added after cooling, ethanol content is made to be 55%(volume fraction), leave standstill 24 hours, filter, precipitate with 55% washing with alcohol (volume fraction), filter, merging filtrate, reclaim ethanol, concentrating under reduced pressure obtains the thick paste (75 DEG C) that density is 1.20-1.25g/ml, spraying dry, obtain mixture D,
(3) get Pollen Typhae, Radix Paeoniae Rubra, the Flos Sophorae Immaturus, Fructus Foeniculi, Rhizoma Dioscoreae, Semen Coicis, geranium, the Radix Angelicae Dahuricae, Radix Notoginseng, Myrrha, Rhizoma Curcumae Longae, Cortex Magnoliae Officinalis, Fructus Psoraleae, Cortex Moutan, Olibanum add ethanol relative to mixture 3 times of weight 95%, reflux, extract, 2 times, each 2 hours, filtrate merges, be concentrated into the thick paste that density is 1.25g/ml, 80 DEG C of oven dry, are ground into powder, are complex E;
(4) complex E prepared by mixture D, step 3 prepared by clathrate A step 1 prepared and step 2 mixes, and adds adjuvant carboxymethyl starch, magnesium stearate, and mixing, is pressed into 1000, film coating, obtains final product.
Embodiment 3
Toxicity test:
This experiment adopts healthy SD rat, the drug dose gradient that respectively prepared by oral administration embodiment 1-2 is 0.05g/kg and 0.5g/kg, successive administration 30 days, during observing rat administration and after drug withdrawal, within 1 week, growth of animal state, movable diet, hematology, blood biochemical analysis, organs and tissues structure and routine urinalysis etc. all have no significant effect, and show that clinical drug safety is reliable.
Embodiment 4
Clinical efficacy is summed up:
General data, drug particles of the present invention is applied to clinical observation 120 example
Diagnostic criteria and severity Scaling: with reference to Ministry of Health of the People's Republic of China. the guideline of clinical investigations .1997.1-2. of new Chinese medicine treatment premenstrual tension syndrome formulates and formulates with reference to " new Chinese medicine treatment premenstrual tension syndrome guideline of clinical investigations ".1. slight: micro-have headache, dizzy, breast is done swollen, or slightly feels pain, in a disturbed state of mind, and face is impractical, and work and study are as usual.2. moderate: dizziness headache, breast is done swollen, vexed insomnia, psychentonia or melancholy, limb edema, still can work and study.3. severe: severe headache is unbearably, dizzy, blurring of vision, cardiopalmus sleeplessness, distending pain of the breast, can not touch clothing, face extremity or whole body swelling, finger submerged while pressing, or body weight increases by 1 ~ 2kg, can not adhere to working and learning.Include in and exclusion standard: meet above-mentioned disease diagnostic criteria, the age, at 18 ~ 40 years old, holds disease person without obviously merging under the arm include observation case in double.Meet inclusive criteria but belong to gestation or women breast-feeding their children, being associated with the severe primary diseases such as cardiovascular, kidney and hemopoietic system, psychotic gets rid of.
Grouping and Therapeutic Method: patient 120 example is observed in this test altogether, adopt and be divided into three groups at random, matched group, embodiment 1 group, embodiment 2 groups, often organizes each 40 people, and grouping case age, the course of disease, the state of an illness, symptom, basal body temperature, hormonal readiness are through statistical procedures, difference that there are no significant, tool comparability.
Matched group: select premenstrual peace sheet, 0.37g/ sheet, Dongguan City Asia Pharmaceutical Co., Ltd, oral one time 5,2 times on the one, each menstruation come within first 14 days, starts to take medicine, take to menstrual onset and drug withdrawal, 3 menstrual cycle of taking medicine continuously are a course for the treatment of;
Embodiment 1-2 group gives medicine prepare with the embodiment of the present invention 1 and embodiment 2 respectively, oral one time 1,3 times on the one, each menstruation starts to take medicine for first 14 days, and take to menstrual onset and drug withdrawal, 3 menstrual cycle of taking medicine continuously are a course for the treatment of.
Curative effect determinate standard: cure: clinical symptom disappearance, examination of basal body temperature or endocrine measure normal, and treatment terminates rear observation 3 menstrual cycle without recurrence.Effective: cardinal symptom obtains controlling extent and alleviates to some extent, though treatment terminates rear section symptom repeatedly, comparatively alleviate to some extent before treatment, basal body temperature or endocrine measure close to normal.Invalid: various clinical symptoms is without improvement or increase the weight of.To clinical recovery after treatment and effective patient, follow up a case by regular visits to 3 menstrual cycle, observe and whether recur.Result is as shown in table 1 below:
Table 1
| Number of cases | Cure | Effectively | Invalid | Total effective rate | |
| Matched group | 40 | 19 | 10 | 11 | 72.5% |
| Embodiment 1 group | 40 | 27 | 9 | 4 | 90％ |
| Embodiment 2 groups | 40 | 35 | 5 | 0 | 100％ |
As seen from the above table: the cure rate that embodiment is 2 groups and total effective rate are all obviously better than matched group, have significant difference.
Embodiment 4
Model case
Thank certain, 21 years old, for many years, before and after menstrual period, lower abdomen hurt like hell, feels restless dysmenorrhea, and have a strong impact on work and study and daily life, official holiday front waist is ached, cold limbs.Menstrual cycle 35-40 days, purple coloured menses, less through measuring, clot is more, and leukorrhagia is without exception.Be diagnosed as premenstrual tension syndrome, give the embodiment of the present invention 2 prepare pharmaceutical composition, one time 1,3 times on the one, from the 6th day of menstrual cycle, serve on 14 days.Pain relief during menstrual onset next time, can bear certainly, slightly fresh through color, and 4 days clean.Take medicine continuously 2 months, dysmenorrhea more, is followed up a case by regular visits to painless through occurring after 1 year.
What more than enumerate is only best specific embodiment of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all should think protection scope of the present invention.
Claims (4)
1., for alleviating a pharmaceutical composition for symptom before feminine menstrual, it is prepared by the raw material of following weight proportioning and obtains:
Radix Bupleuri 400g, Fructus Aurantii 400g, Cortex Albiziae 320g, Radix Curcumae 320g, Rhizoma Cyperi 320g,
Pericarpium Citri Reticulatae Viride 240g, Fructus Liquidambaris 280g, Semen Citri Reticulatae 240g, Radix Angelicae Sinensis 320g, Radix Paeoniae Alba 320g,
Rhizoma Chuanxiong 240g, Poria 240g, Pericarpium Arecae 240g, Radix Glycyrrhizae 120g.
2. pharmaceutical composition described in claim 1, is characterized in that preparation method is as follows:
Above-mentioned raw materials medicine is taken for subsequent use according to above-mentioned weight:
(1) get Radix Bupleuri, Fructus Aurantii, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, the Rhizoma Chuanxiong way of distillation extract volatile oil; volatile oil beta cyclodextrin makes clathrate A; the volume ratio of volatile oil and beta cyclodextrin is 1:6; medicinal residues after distillation add 8 times of weight water and decoct 2 times; 1 hour first time; half an hour for the second time, merge decoction liquor, obtain liquid B;
(2) get Cortex Albiziae, Fructus Liquidambaris, Semen Citri Reticulatae, the Radix Paeoniae Alba, Poria, Pericarpium Arecae, Radix Glycyrrhizae decoct with water twice; first time adds the soak by water 2 hours of 10 times of weight; second time adds 8 times of weight water and decocts 1 hour; merge twice decoction liquor; obtain liquid C; liquid B and liquid C are mixed, it is the thick paste of 1.20-1.25g/ml that concentrating under reduced pressure obtains density, adds ethanol after cooling; leave standstill; filter, precipitation washing with alcohol, filter; merging filtrate; it is the thick paste of 1.20-1.25g/ml that concentrating under reduced pressure obtains density, spraying dry, obtains mixture D;
(3) mixture D mixing prepared by clathrate A step 1 prepared and step 2, prepares 1000, tablet.
3., for alleviating a pharmaceutical composition for symptom before feminine menstrual, it is prepared by the raw material of following weight proportioning and obtains:
Radix Bupleuri 400g, Fructus Aurantii 400g, Cortex Albiziae 320g, Radix Curcumae 320g, Rhizoma Cyperi 320g,
Pericarpium Citri Reticulatae Viride 240g, Fructus Liquidambaris 280g, Semen Citri Reticulatae 240g, Radix Angelicae Sinensis 320g, Radix Paeoniae Alba 320g,
Rhizoma Chuanxiong 240g, Poria 240g, Pericarpium Arecae 240g, Radix Glycyrrhizae 120g, Pollen Typhae 120g,
Radix Paeoniae Rubra 100g, Flos Sophorae Immaturus 80g, Fructus Foeniculi 80g, Rhizoma Dioscoreae 80g, Semen Coicis 50g,
Geranium 50g, Radix Angelicae Dahuricae 50g, Radix Notoginseng 50g, Myrrha 50g, Rhizoma Curcumae Longae 50g,
Cortex Magnoliae Officinalis 30g, Fructus Psoraleae 30g, Cortex Moutan 20g, Olibanum 20g.
4. pharmaceutical composition according to claim 3, is characterized in that, the preparation method of described pharmaceutical composition comprises the steps:
(1) Radix Bupleuri, Fructus Aurantii, Radix Curcumae, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis, Rhizoma Chuanxiong is got, mixing, volatile oil is extracted by the way of distillation, volatile oil beta cyclodextrin makes clathrate A, and the volume ratio of volatile oil and beta cyclodextrin is 1:6, and the medicinal residues after distillation add 8 times of weight water and decoct 2 times, 1 hour first time, half an hour for the second time, merge decoction liquor, obtain liquid B;
(2) Cortex Albiziae, Fructus Liquidambaris, Semen Citri Reticulatae, the Radix Paeoniae Alba, Poria, Pericarpium Arecae, Radix Glycyrrhizae is got, mixing, decoct with water twice, first time adds the soak by water 2 hours of 10 times of weight, and second time adds 8 times of weight water and decocts 1 hour, merges twice decoction liquor, obtain liquid C, liquid B and liquid C are mixed, it is the thick paste of 1.20-1.25g/ml that concentrating under reduced pressure obtains density, adds ethanol after cooling, leave standstill, filter, precipitation washing with alcohol, filter, merging filtrate, it is the thick paste of 1.20-1.25g/ml that concentrating under reduced pressure obtains density, spraying dry, obtains mixture D;
(3) get surplus stock, mixing, adds the ethanol of 3 times of weight 95%, reflux, extract, 2 times, each 2 hours, and filtrate merges, and be concentrated into the thick paste that density is 1.25g/ml, 80 DEG C of oven dry, are ground into powder, are complex E;
(4) mixture D prepared by clathrate A step (1) prepared, step (2) and complex E prepared by step (3) mix, and are prepared into tablet, obtain final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106729405A (en) * | 2016-12-27 | 2017-05-31 | 翔宇药业股份有限公司 | Pharmaceutical preparation and preparation method thereof for treating premenstrual syndrome |
| CN106729406A (en) * | 2016-12-27 | 2017-05-31 | 翔宇药业股份有限公司 | The preparation method of premenstrual peace preparation |
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| JP2007500245A (en) * | 2003-06-10 | 2007-01-11 | スミスクライン ビーチャム コーポレーション | Compound |
| CN103446567A (en) * | 2013-08-30 | 2013-12-18 | 林凡友 | Premenstrual ease pharmaceutical composition and preparation technique thereof |
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| CN1220163A (en) * | 1998-11-12 | 1999-06-23 | 东莞市亚洲制药有限公司 | Drug for curing premenstrual tension |
| JP2007500245A (en) * | 2003-06-10 | 2007-01-11 | スミスクライン ビーチャム コーポレーション | Compound |
| CN103446567A (en) * | 2013-08-30 | 2013-12-18 | 林凡友 | Premenstrual ease pharmaceutical composition and preparation technique thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106729405A (en) * | 2016-12-27 | 2017-05-31 | 翔宇药业股份有限公司 | Pharmaceutical preparation and preparation method thereof for treating premenstrual syndrome |
| CN106729406A (en) * | 2016-12-27 | 2017-05-31 | 翔宇药业股份有限公司 | The preparation method of premenstrual peace preparation |
| CN106729405B (en) * | 2016-12-27 | 2020-06-02 | 翔宇药业股份有限公司 | Pharmaceutical preparation for treating premenstrual syndrome and preparation method thereof |
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Application publication date: 20160106 |