CN109464551A - Wind resistance wet gel and preparation method thereof - Google Patents
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The present invention relates to a kind of wind resistance wet gels and preparation method thereof, wherein, the preparation method of wind resistance wet gel is the following steps are included: by 0.5-2 parts of 0.5-3 parts of romanet grape root, 0.3-2 parts of Japanese Cayratia Herb, 0.5-2 parts of Chinese atropanthe root, 0.5-2 parts of borneol camphor tree leaf and big vast eucalyptus camphor tree leaf mixing, pharmaceutically acceptable solvent extraction is added, filtrate is collected in filtering；Carbomer is added into filtrate, forms gel filtrate；Wintergreen, eucalyptus oil and capsaicine are added into gel filtrate to be emulsified to get wind resistance wet gel.The wind resistance wet gel has preferable osmosis, can be good at penetrating into skin, alleviates joint swelling and pain symptom rapidly.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, in particular to a kind of wind resistance wet gel and preparation method thereof.
Background technique
Rheumatism refers to the main soft tissue for invading joint, muscle, bone and periarticular, such as tendon, ligament, synovial bursa, muscle
The disease at the positions such as film.Rheumatism is the abbreviation of rheumatic disease in modern medicine concept, is a big group disease.Rheumatic diseases
Whole body connective tissue is involved in change, is in acute or chronic connective tissue inflammation, the predominantly denaturation and necrosis of collagenous fibres, is one group
Joint, bone, muscle, the disease based on blood vessel and related soft tissue or connective tissue are invaded, wherein most is autoimmune
Disease.It falls ill how more covert and slow, the course of disease is longer.Chinese medicine is divided by etiological classification: wandering arthritis, arthritis, arthritis with fixed pain caused by dampness, hot numbness, dry numbness,
Wind-cold-dampness arthralgia, 7 class of damp-heat arthralgia.
Rheumatism generally uses hormone medicine at present, such drug has the function of preferable analgesic antiphlogistic, and uses
It is convenient, it can be carried around, but such drug can only play the role of postponement, be easy recurrence, side effect is larger.Therefore it is more and more
Patient is inclined to use Chinese medicine, but most of Chinese medicines, based on oral, long-time service is easy to cause lesions of liver and kidney, and curative effect is slower,
Especially for the bad patient of stomach, absorption is poor, and long-time service is also easy to cause diarrhea, in addition, oral class Chinese medicine infusion
It is relatively complicated, so using limited.
Summary of the invention
Based on this, it is necessary to provide a kind of wind resistance wet gel and preparation method thereof, which not only has preferably
Antirheumatic curative effect, and easy to use, curative effect is rapid.
A kind of preparation method of wind resistance wet gel, comprising the following steps:
By 0.5-3 parts of romanet grape root, 0.3-2 parts of Japanese Cayratia Herb, 0.5-2 parts of Chinese atropanthe root, 0.5-2 parts of borneol camphor tree leaf and big vast eucalyptus camphor tree
0.5-2 parts of leaf mixing, are added pharmaceutically acceptable solvent extraction, filter, and collect filtrate；
Carbomer is added into the filtrate, forms gel filtrate；
Wintergreen, eucalyptus oil and capsaicine are added into the gel filtrate to be emulsified to get the wind resistance wet gel.
In one embodiment, the quality of the carbomer is the 1%-3% of the gross mass of the filtrate.
In one embodiment, the quality of the wintergreen is the 1%-3% of the gross mass of the filtrate.
In one embodiment, the quality of the eucalyptus oil is the 2%-3% of the gross mass of the filtrate.
In one embodiment, the quality of capsaicine is the 0.5%-5% of the gross mass of the filtrate.
In one embodiment, the romanet grape root is 0.8-2.2 parts, and the Japanese Cayratia Herb is 0.5-1.3 parts, described to search
Mountain tiger is 0.8-1.2 parts, and the borneol camphor tree leaf is 0.8-1.2 parts, and the flood eucalyptus camphor tree leaf is 0.8-1.2 parts.
In one embodiment, the weight ratio of the romanet grape root, the borneol camphor tree leaf and the big vast eucalyptus camphor tree leaf is (1-
2): 1:1.
In one embodiment, the solvent is the rice wine that ethanol content is 40%-60%.
In one embodiment, the weight ratio of the rice wine and the drug of addition is (12-15): 1, wherein
The drug be romanet grape root, the Japanese Cayratia Herb, the Chinese atropanthe root, the borneol camphor tree leaf and the big vast eucalyptus camphor tree leaf mixture.
The wind resistance wet gel that above-mentioned preparation method is prepared.
Above-mentioned antirheumatic gel process for preparing is based on romanet grape root, Japanese Cayratia Herb, Chinese atropanthe root, borneol camphor tree leaf and Hong An camphor tree leaf
Body raw material, and it is aided with wintergreen, eucalyptus oil, so that the wind resistance wet gel has stronger anti rheumatism action.And due to above-mentioned original
The extracting solution of material has preferable osmosis, can be good at penetrating into skin, alleviates joint swelling and pain symptom rapidly.
And the above method adds carbomer and gel filtrate is made, be eventually adding capsaicine and gel is made by first extracting active component
Preparation effectively improves the applicability of the gel, and less side effects compared to oral preparation, curative effect is rapider, and using more
It is convenient.
Wherein, romanet grape root is the root of vitaceae autumn grape or Vitis davidii Foex, and romanet grape root is cold in nature, sweet-bitter flavor, nontoxic,
It relieves the pain with detumescence, activating microcirculation and removing stasis medicinal, myogenic and other effects.
The sour hardship of Japanese Cayratia Herb is trembled with fear, nontoxic, has the effects of clearing heat and detoxicating, cool blood detumescence, diuresis；Chinese atropanthe root, acrid flavour, property
Temperature has the function of wind-damp dispelling, relaxing tendons and activating collaterals, swelling and pain relieving.
Borneol camphor tree leaf is China's tradition rare traditional Chinese medicine and fine perfumery, and borneol, that is, natural borneol is listed in successive dynasties imperial palace
" tribute ", it has the medicinal functions such as inducing resuscitation of having one's ideas straightened out, clearing heat and detoxicating, swelling and pain relieving, wind dispelling resolving sputum.
Big vast eucalyptus camphor tree leaf is rich in cineole abundant, has the effects that antibacterial, dispelling wind be antipyretic, clearing damp is detoxified.
Wintergreen also known as checkerberry oil are a kind of essential oil, by heath (azalea) section plant teaberry (wintergreen)
Leaf distillation and obtain, containing similar to aspirin chemical substance, can relieve pain, reduce swelling and generate heat.And wintergreen is one
Kind natural astringent and preservative, can resist scytitis, and killing on skin is bacterium.Furthermore wintergreen or one kind
Natural diuretics, low dose of use can increase gastric acid secretion, and then improve digestion.By adding wintergreen, on the one hand may be used
To enhance fragrance, the acceptable degree of patient is improved；On the other hand it can act synergistically with other active components, enhance above-mentioned antirheumatic
The anti-inflammatory analgetic of composition acts on.
Eucalyptus oil is otherwise known as eucalyptol, cajuputole etc., mainly from eucalyptus oil, camphorated oil, cajaput oils, laurel
It is extracted in equal plants, state is colourless or flaxen oily liquids, have effects that detoxify heat-clearing, dehumidifying toxin expelling,
It also has very strong bacteriostasis simultaneously, can effectively inhibit staphylococcus aureus, Escherichia coli, pneumococcus, dysentery
On the one hand the anti-inflammatory effect of listing wind resistance wet gel can be improved by addition eucalyptus oil, on the other hand may be used for the bacteriums such as Shigella
To improve the quality of gel as stabilizer and preservative.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with
Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
Specific embodiment is set forth below, and the present invention will be described.
Embodiment 1
Raw material: 0.5 part of romanet grape root, 0.3 part of Japanese Cayratia Herb, 0.5 part of Chinese atropanthe root, 0.5 part of borneol camphor tree leaf, big vast eucalyptus camphor tree leaf 0.5
Part；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtrate is collected in filtering；2% carbomer of the gross mass of filtrate is added into filtrate, forms gel filtrate；
2% wintergreen, 2% eucalyptus oil and 1% capsaicine of the gross mass of filtrate, completion to be emulsified are added into gel filtrate
Afterwards up to the wind resistance wet gel of embodiment 1.
Embodiment 2
Raw material: 1 part of romanet grape root, 0.6 part of Japanese Cayratia Herb, 0.8 part of Chinese atropanthe root, 0.8 part of borneol camphor tree leaf, big vast 0.8 part of camphor tree leaf of eucalyptus；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtrate is collected in filtering；2% carbomer of the gross mass of filtrate is added into filtrate, forms gel filtrate；
3% wintergreen, 1% eucalyptus oil and 1% capsaicine of the gross mass of filtrate, completion to be emulsified are added into gel filtrate
Afterwards up to the wind resistance wet gel of embodiment 2.
Embodiment 3
Raw material: 2 parts of romanet grape root, 1 part of Japanese Cayratia Herb, 1 part of Chinese atropanthe root, 1 part of borneol camphor tree leaf, big vast 1 part of camphor tree leaf of eucalyptus；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtrate is collected in filtering；3% carbomer of the gross mass of filtrate is added into filtrate, forms gel filtrate；
3% wintergreen, 3% eucalyptus oil and 1% capsaicine of the gross mass of filtrate, completion to be emulsified are added into gel filtrate
Afterwards up to the wind resistance wet gel of embodiment 3.
Embodiment 4
Raw material: 3 parts of romanet grape root, 1.5 parts of Japanese Cayratia Herb, 1.5 parts of Chinese atropanthe root, 1.5 parts of borneol camphor tree leaf, big vast 1.5 parts of camphor tree leaf of eucalyptus；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtrate is collected in filtering；2% carbomer of the gross mass of filtrate is added into filtrate, forms gel filtrate；
2% wintergreen, 2% eucalyptus oil and 1% capsaicine of the gross mass of filtrate, completion to be emulsified are added into gel filtrate
Afterwards up to the wind resistance wet gel of embodiment 4.
Embodiment 5
Raw material: 3 parts of romanet grape root, 2 parts of Japanese Cayratia Herb, 2 parts of Chinese atropanthe root, 2 parts of borneol camphor tree leaf, big vast 2 parts of camphor tree leaf of eucalyptus；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtrate is collected in filtering；2% carbomer of the gross mass of filtrate is added into filtrate, forms gel filtrate；
2% wintergreen, 2% eucalyptus oil and 1% capsaicine of the gross mass of filtrate, completion to be emulsified are added into gel filtrate
Afterwards up to the wind resistance wet gel of embodiment 5.
Comparative example 1
Raw material: 3 parts of romanet grape root, 1.5 parts of Japanese Cayratia Herb, 1.5 parts of Chinese atropanthe root, 1.5 parts of borneol camphor tree leaf, big vast 1.5 parts of camphor tree leaf of eucalyptus；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtering, 2% wintergreen of the gross mass of filtrate, 2% eucalyptus oil is added, stirs evenly, it is filling to get
The antirheumatic spray liquid of comparative example 1.
Clinical trial
For the curative effect for verifying antirheumatic composition of the invention, choose there is rheumatism symptom patient 100 (male 50,
Female 50, the age 30-80 years old, average age 48 years old), it is equally divided into two groups, first group of wind resistance wet gel for using embodiment 4,
Second group of antirheumatic spray liquid using comparative example 1, first group of test result such as table 1, second group of test result such as table 2.
Inclusion criteria: there is red joint, swollen, hot, pain and dysfunction, limb muscle ache inability, the tired, appetite in the whole body
The patient of the typical rheumatism symptom such as shortage, irritated, the irregular fever of painful area；
Application method: each primary daily morning and evening, using two weeks, record used remission after 2 days, 5 days, 7 days and 14 days
Situation；
Judgment criteria:
Cure: each symptom and clinical sign disappear, other objective determination indexs are normal；
Effective: each symptom and clinical sign are substantially reduced, other objective determination indexs are obviously improved；
Effective: each symptom and clinical sign mitigate, other objective determination indexs make moderate progress；
Invalid: each symptom and clinical sign without improvement or aggravate, other objective determination target improvements or exacerbation.
Table 1
Table 2
As it can be seen that the wind resistance wet gel of embodiment 4 and the antirheumatic spray liquid of comparative example 1 all have preferable curative effect, wherein
The effective percentage of the wind resistance wet gel of embodiment 4 reaches 98%, and the effective percentage of comparative example 1 reaches 92% or so.Illustrate changing for dosage form
Become, curative effect has a degree of promotion, it may be possible to preferably be absorbed since gel preparation has.
Typical case analysis:
Case 1: Jiang, male 37 years old, suffer from rheumatic lumbago 3 years or so, have a pain in the back often, when recurrent pain is serious
Using the drug that relieves the pain, and commercially available antirheumatic patch is used simultaneously, symptom has to be alleviated to a certain degree, but recurrence frequency is higher, and 2018
Begin to use the wind resistance wet gel of embodiment 4 at the beginning of 3 months years, 1 week or so, the state of an illness was alleviated, it is discontinued within medication 2 weeks or so, 1 month
Continue medication two weeks afterwards, be then discontinued, repeatedly, in July, 2018 starts to be discontinued, to not recurring at present.
Case 2: what certain, male 68 years old, suffers from rheumatic arthritis, on ordinary days herbal treatment always, persistently have 2 years, though the state of an illness
Alleviate to a certain extent, but recurrence frequency is still higher, and when morbidity, which can not stand, walks about, and occurs painful swelling of joints, knee joint once in a while
The symptoms such as tetanic, in May, 2017 are begun to use the wind resistance wet gel of embodiment 4, were improved using 1 week or so, and 3 months stop
Medicine does not recur at present.
Case 3: Mr. Wang, male, 47 years old, rheumatic lumbocrural pain attempted a variety of drugs without biggish curative effect, and 2017 4
The moon begins to use the wind resistance wet gel of embodiment 4, and using one week, symptom was alleviated, and is disappeared substantially using symptom after three weeks, until
The present does not recur.
Case 4: the Qin, female, 52 years old, be after diagnosing rheumatoid arthritis, takes Western medicine for a long time, and attempted various objects
Physical therapy method, effect are unobvious.In July, 2016, symptom start to aggravate, and affected joints increased significantly, and occur joint deadlock once in a while
Hard symptom needs to lie in bed, and can not move freely.In September, 2016 just begins to use the wind resistance wet gel of embodiment 4, uses 1 week
Left and right, symptom are mitigated, adhere to one month or so, be almost recovered, not yet recur so far.
Case 5: Lee, male, 62 years old, bilateral type joint swelling pain was stiff once in a while, and infusion oral drugs have to a certain degree
Alleviation, but recurrence frequency is higher, entire disease of hand when serious, and has dizzy symptom, begins to use implementation in January, 2018
The wind resistance wet gel of example 4 started to be alleviated using 3 days or so symptoms, adhered to being almost recovered, at present still using 1 month or so
It does not recur.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of preparation method of wind resistance wet gel, which comprises the following steps:
By 0.5-3 parts of romanet grape root, 0.3-2 parts of Japanese Cayratia Herb, 0.5-2 parts of Chinese atropanthe root, 0.5-2 parts of borneol camphor tree leaf and big vast eucalyptus camphor tree leaf
0.5-2 parts of mixing, are added pharmaceutically acceptable solvent extraction, filter, and collect filtrate；
Carbomer is added into the filtrate, forms gel filtrate；
Wintergreen, eucalyptus oil and capsaicine are added into the gel filtrate to be emulsified to get the wind resistance wet gel.
2. the preparation method of wind resistance wet gel according to claim 1, which is characterized in that the quality of the carbomer is institute
State the 1%-3% of the gross mass of filtrate.
3. the preparation method of wind resistance wet gel according to claim 1, which is characterized in that the quality of the wintergreen is institute
State the 1%-3% of the gross mass of filtrate.
4. the preparation method of wind resistance wet gel according to claim 1, which is characterized in that the quality of the eucalyptus oil is institute
State the 2%-3% of the gross mass of filtrate.
5. the preparation method of wind resistance wet gel according to claim 1, which is characterized in that the quality of the capsaicine is institute
State the 0.5%-5% of the gross mass of filtrate.
6. the preparation method of wind resistance wet gel according to claim 1-4, which is characterized in that the romanet grape root
It is 0.8-2.2 parts, the Japanese Cayratia Herb is 0.5-1.3 parts, and the Chinese atropanthe root is 0.8-1.2 parts, and the borneol camphor tree leaf is 0.8-1.2
Part, the flood eucalyptus camphor tree leaf is 0.8-1.2 parts.
7. the preparation method of wind resistance wet gel according to claim 1-4, which is characterized in that the bryony
The weight ratio of root, the borneol camphor tree leaf and the big vast eucalyptus camphor tree leaf is (1-2): 1:1.
8. the preparation method of wind resistance wet gel according to claim 1-4, which is characterized in that the solvent is second
Alcohol content is the rice wine of 40%-60%.
9. the preparation method of wind resistance wet gel according to claim 1-4, which is characterized in that the rice wine and medicine
The weight ratio of object is (12-15): 1, wherein the drug is romanet grape root, the Japanese Cayratia Herb, the Chinese atropanthe root, the dragon
The mixture of brain camphor tree leaf and the big vast eucalyptus camphor tree leaf.
10. the wind resistance wet gel that the described in any item preparation methods of claim 1-9 are prepared.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110731996A (en) * | 2019-12-08 | 2020-01-31 | 怀化五零三侗医药科技开发有限公司 | A Chinese medicinal composition for treating rheumatic arthralgia, and its application |
| CN110755530A (en) * | 2019-12-08 | 2020-02-07 | 怀化五零三侗医药科技开发有限公司 | Traditional Chinese medicine composition for treating cervical spondylosis and application thereof |
| CN111657496A (en) * | 2020-06-24 | 2020-09-15 | 山东朱氏药业集团有限公司 | Emu oil, preparation process and preparation system thereof |
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| CN110755530A (en) * | 2019-12-08 | 2020-02-07 | 怀化五零三侗医药科技开发有限公司 | Traditional Chinese medicine composition for treating cervical spondylosis and application thereof |
| CN111657496A (en) * | 2020-06-24 | 2020-09-15 | 山东朱氏药业集团有限公司 | Emu oil, preparation process and preparation system thereof |
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