CN109288933A - Antirheumatic composition, antirheumatic spray liquid and its preparation method and application - Google Patents
Antirheumatic composition, antirheumatic spray liquid and its preparation method and application Download PDFInfo
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- CN109288933A CN109288933A CN201811496713.6A CN201811496713A CN109288933A CN 109288933 A CN109288933 A CN 109288933A CN 201811496713 A CN201811496713 A CN 201811496713A CN 109288933 A CN109288933 A CN 109288933A
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- antirheumatic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Abstract
The present invention relates to a kind of antirheumatic composition, antirheumatic spray liquid and its preparation method and application, which includes: 0.5-3 parts of romanet grape root, 0.3-2 parts of Japanese Cayratia Herb, 0.5-2 parts of Chinese atropanthe root, 0.5-2 parts of borneol camphor tree leaf and big vast 0.5-2 parts of eucalyptus camphor tree leaf.Each mutual compatibility of active component in above-mentioned antirheumatic composition, synergistic effect is so that the antirheumatic composition has potent anti rheumatism action, and is not likely to produce dependence.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, in particular to a kind of antirheumatic composition, antirheumatic spray liquid and its preparation
Methods and applications.
Background technique
Rheumatism refers to the main soft tissue for invading joint, muscle, bone and periarticular, such as tendon, ligament, synovial bursa, muscle
The disease at the positions such as film.Rheumatism is the abbreviation of rheumatic disease in modern medicine concept, is a big group disease.Rheumatic diseases
Whole body connective tissue is involved in change, is in acute or chronic connective tissue inflammation, the predominantly denaturation and necrosis of collagenous fibres, is one group
Joint, bone, muscle, the disease based on blood vessel and related soft tissue or connective tissue are invaded, wherein most is autoimmune
Disease.It falls ill how more covert and slow, the course of disease is longer.Chinese medicine is divided by etiological classification: wandering arthritis, arthritis, arthritis with fixed pain caused by dampness, hot numbness, dry numbness,
Wind-cold-dampness arthralgia, 7 class of damp-heat arthralgia.
Current diagnosis rheumatism generally uses hormone medicine, such drug has the function of preferable analgesic antiphlogistic, but
Such drug can only play the role of postponement, not only be easier to recur, and there is also certain side effects, so Chinese medicine treatment is gradually
Climb up the stage of rheumatism treatment.It the use of more Chinese medicine preparation is ginger, monkshood, river radix aconiti agrestis, vomiting nut etc. is active component
Formula, such formula is usually required to take orally, be worked slower, and is taken for a long time and be easy to cause lesions of liver and kidney.
Summary of the invention
Based on this, it is necessary to provide a kind of antirheumatic composition, antirheumatic spray liquid for capableing of rapid recovery rheumatalgia pain
And its preparation method and application.
A kind of antirheumatic composition, the active component including following parts by weight:
Above-mentioned antirheumatic composition is mainly made of romanet grape root, Japanese Cayratia Herb, Chinese atropanthe root, borneol camphor tree leaf and Hong An camphor tree leaf.
Wherein, romanet grape root is the root of vitaceae autumn grape or Vitis davidii Foex, and romanet grape root is cold in nature, sweet-bitter flavor, nontoxic, has detumescence
It relieves the pain, activating microcirculation and removing stasis medicinal, myogenic are put on flesh and other effects；The sour hardship of Japanese Cayratia Herb is trembled with fear, nontoxic, has clearing heat and detoxicating, cool blood detumescence, diuresis
The effects of；Chinese atropanthe root, acrid flavour is warm-natured, has the function of wind-damp dispelling, relaxing tendons and activating collaterals, swelling and pain relieving；Borneol camphor tree leaf is China's tradition
Rare traditional Chinese medicine and fine perfumery, borneol, that is, natural borneol are listed in successive dynasties imperial palace " tribute ", it has inducing resuscitation of having one's ideas straightened out, heat-clearing
The medicinal functions such as removing toxic substances, swelling and pain relieving, wind dispelling resolving sputum；Big vast eucalyptus camphor tree leaf is rich in cineole abundant, has antibacterial, dispelling wind solution
The effects of heat, clearing damp removing toxic substances.Each mutual compatibility of active component in above-mentioned antirheumatic composition acts synergistically so that the antirheumatic
Composition has potent anti rheumatism action, and is not likely to produce dependence.
In one embodiment, in the antirheumatic composition, the romanet grape root is 0.8-1.5 parts, the crow liana
The certain kind of berries is 0.5-1.3 parts, and the Chinese atropanthe root is 0.8-1.2 parts, and the borneol camphor tree leaf is 0.8-1.2 parts, and the flood eucalyptus camphor tree leaf is
0.8-1.2 parts.
In one embodiment, in the antirheumatic composition, the romanet grape root, the borneol camphor tree leaf and the flood
The weight ratio of eucalyptus camphor tree leaf is (1-2): 1:1.
Composition in the proportional region has better antirheumatic curative effect.
In one embodiment, above-mentioned antirheumatic composition further includes wintergreen, and the wintergreen accounts for the antirheumatic
The weight percentage of composition is 2.5 ‰~4.5 ‰.
Wintergreen also known as checkerberry oil are a kind of essential oil, by heath (azalea) section plant teaberry (wintergreen)
Leaf distillation and obtain, containing similar to aspirin chemical substance, can relieve pain, reduce swelling and generate heat.And wintergreen is one
Kind natural astringent and preservative, can resist scytitis, and killing on skin is bacterium.Furthermore wintergreen or one kind
Natural diuretics, low dose of use can increase gastric acid secretion, and then improve digestion.By in above-mentioned antirheumatic composition
Wintergreen is added, fragrance on the one hand can be enhanced, improves the acceptable degree of patient；On the other hand it can be cooperateed with other active components
Effect enhances the anti-inflammatory analgetic effect of above-mentioned antirheumatic composition.
Above-mentioned antirheumatic composition is preparing the application in antirheumatic.
A kind of antirheumatic spray liquid, including above-mentioned antirheumatic composition.
By the way that spraying liquid formulation is made in above-mentioned antirheumatic composition, directly rheumatism position can be administered, quickly detumescence stops
Bitterly, convenient and efficient.
A kind of preparation method of antirheumatic spray liquid, comprising the following steps:
By 0.5-3 parts of romanet grape root, 0.3-2 parts of Japanese Cayratia Herb, 0.5-2 parts of Chinese atropanthe root, 0.5-2 parts of borneol camphor tree leaf and big vast eucalyptus camphor tree
0.5-2 parts of leaf mixing, are added pharmaceutically acceptable solvent extraction；Filtering collects filtrate up to the antirheumatic spray liquid.
Above-mentioned antirheumatic composition material is from a wealth of sources, and preparation method is easy, is not necessarily to specific apparatus and special operation, tool
There is wider applicability.
In one embodiment, after collecting filtrate further include the steps that the wintergreen is added.
In one embodiment, the solvent is the rice wine that ethanol content is 40%-60%.
In one embodiment, the ratio between the weight of the rice wine of addition and the total weight of drug are (12-15): 1,
Described in drug be addition the romanet grape root, the Japanese Cayratia Herb, the Chinese atropanthe root, the borneol camphor tree leaf and the big vast eucalyptus camphor tree
Mixture.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with
Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
Specific embodiment is set forth below, and the present invention will be described.
Embodiment 1
Raw material: 0.5 part of romanet grape root, 0.3 part of Japanese Cayratia Herb, 0.5 part of Chinese atropanthe root, 0.5 part of borneol camphor tree leaf, big vast eucalyptus camphor tree leaf 0.5
Part；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtering is added the wintergreen of raw material gross weight 3/1000ths, stirs evenly, the filling wind resistance to get embodiment 1
Wet shot spray film.
Embodiment 2
Raw material: 1 part of romanet grape root, 0.6 part of Japanese Cayratia Herb, 0.8 part of Chinese atropanthe root, 0.8 part of borneol camphor tree leaf, big vast 0.8 part of camphor tree leaf of eucalyptus；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtering is added the wintergreen of raw material gross weight 3/1000ths, stirs evenly, the filling wind resistance to get embodiment 2
Wet shot spray film.
Embodiment 3
Raw material: 2 parts of romanet grape root, 1 part of Japanese Cayratia Herb, 1 part of Chinese atropanthe root, 1 part of borneol camphor tree leaf, big vast 1 part of camphor tree leaf of eucalyptus；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtering is added the wintergreen of raw material gross weight 3/1000ths, stirs evenly, the filling wind resistance to get embodiment 3
Wet shot spray film.
Embodiment 4
Raw material: 3 parts of romanet grape root, 1.5 parts of Japanese Cayratia Herb, 1.5 parts of Chinese atropanthe root, 1.5 parts of borneol camphor tree leaf, big vast 1.5 parts of camphor tree leaf of eucalyptus；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtering is added the wintergreen of raw material gross weight 3/1000ths, stirs evenly, the filling wind resistance to get embodiment 4
Wet shot spray film.
Embodiment 5
Raw material: 3 parts of romanet grape root, 2 parts of Japanese Cayratia Herb, 2 parts of Chinese atropanthe root, 2 parts of borneol camphor tree leaf, big vast 2 parts of camphor tree leaf of eucalyptus；
Preparation method: it takes above-mentioned each raw material to crush, adds 12 times of above-mentioned raw materials total amount of 52 degree of rice wine, mix thoroughly, stir 2 daily
It is secondary, it impregnates 4 weeks.Filtering is added the wintergreen of raw material gross weight 3/1000ths, stirs evenly, the filling wind resistance to get embodiment 5
Wet shot spray film.
Clinical test
For the curative effect for verifying antirheumatic composition of the invention, patient 50 (male 25, the female with rheumatism symptom are chosen
25, the age 30-80 years old, average age 52 years old) use the antirheumatic spray liquid of embodiment 2, test result such as table 1.
Inclusion criteria: there is red joint, swollen, hot, pain and dysfunction, limb muscle ache inability, the tired, appetite in the whole body
The patient of one or more rheumatism symptoms such as shortage, irritated, the irregular fever of painful area；
Application method: each primary daily morning and evening, using two weeks, record used remission after 2 days, 5 days, 7 days and 14 days
Situation；
Judgment criteria:
Cure: each symptom and clinical sign disappear, other objective determination indexs are normal；
Effective: each symptom and clinical sign are substantially reduced, other objective determination indexs are obviously improved；
Effective: each symptom and clinical sign mitigate, other objective determination indexs make moderate progress；
Invalid: each symptom and clinical sign without improvement or aggravate, other objective determination target improvements or exacerbation.
As it can be seen that the antirheumatic spray liquid tool of embodiment 2 has a better effect, effective percentage reaches 92% or so.
Part typical case is selected below to be analyzed:
Case 1: Lee, female 68 years old, are diagnosed as rheumatic arthritis.It takes western medical treatment for a long time, and has used some
The plaster of antirheumatic, effect is unobvious, and since in March, 2018, sb.'s illness took a turn for the worse, limitation of activity, can not stand for a long time, row
It walks, and has dizzy symptom out of strength once in a while.The antirheumatic spray liquid for beginning to use embodiment 3 at the beginning of 5 months 2018, adheres to changing daily
Medicine twice a day (will increase access times) when obvious pain, after 2 weeks, symptom starts to mitigate, and start not shadow within 4 weeks or so
Normal work and rest life is rung, 2 months or so, product is stopped using, does not recur at present.
Case 2: Liu, male 49 years old, are diagnosed as rheumatic lumbocrural pain, are busy with one's work, be negligent for the treatment of, the state of an illness starts
Deteriorate, does not carry out formal therapy before using this product.In June, 2018 begins to use the antirheumatic spray liquid of embodiment 3, makes
It is substantially reduced with symptom after 1 week, it deactivates after 1 month, does not recur at present.
Case 3: the Qin, female 55 years old, suffer from rheumatic arthritis, it is slow to take anti-inflammation analgesic (drugs such as prednisone) for a long time
Pain is solved, the symptoms such as the state of an illness gradually aggravates, and painful swelling of joints occurs, and knee joint is tetanic, in September, 2017 begins to use embodiment 3
Antirheumatic spray liquid 2 days or so, swelling is substantially reduced, 5 days or so, swelling subside, be clearly better within 2 weeks or so, 1 month stops
Medicine does not recur at present.
Case 4: Zhang, female, 57 years old, right hand thumb enlargement, and it is accompanied by shouting pain, and it can not be movable, it is entire when serious
Disease of hand is powerless, influences normal life, once uses plaster, and take anti-inflammatory class Western medicine, no effect；In November, 2016 starts to make
With the antirheumatic spray liquid of embodiment 2, using one week or so, red and swollen symptom was substantially reduced, three weeks or so resolution of symptoms, was discontinued,
It has not relapsed so far.
Case 5: Liu, male 73 years old, often the small of the back, buttocks, hip secret anguish, and readme feel swelling pain point in body
The place of interior migration, each pain is different, but when pain, and with pico- fever, hospital, which checks, does not find the cause of disease, and 2017 1
Using the antirheumatic spray liquid of embodiment 2 when the moon starts to break out every time, 3 days or so after use, symptom disappears substantially, disappears subsequent
It is continuous to use 2 days, hence it is evident that feel that recurrence frequency is reduced.
Case 6: connecting certain, male, and 47, ache with rheumatism joint, the pain increased for rainy weather, uses the anti-of embodiment 2
Rheumatism spray liquid 5 days or so, pain disappeared, and was used continuously 2 weeks, symptom disappears substantially.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of antirheumatic composition, which is characterized in that the active component including following parts by weight:
2. antirheumatic composition according to claim 1, which is characterized in that the romanet grape root is 0.8-2.2 parts, described
Japanese Cayratia Herb is 0.5-1.3 parts, and the Chinese atropanthe root is 0.8-1.2 parts, and the borneol camphor tree leaf is 0.8-1.2 parts, the flood eucalyptus camphor tree leaf
It is 0.8-1.2 parts.
3. antirheumatic composition according to claim 2, which is characterized in that the romanet grape root, the borneol camphor tree leaf and
The weight ratio of the flood eucalyptus camphor tree leaf is (1-2): 1:1.
4. antirheumatic composition according to claim 1-3, which is characterized in that it further include wintergreen, the winter
The weight percentage that green oil accounts for the antirheumatic composition is 2.5 ‰~4.5 ‰.
5. the described in any item antirheumatic compositions of claim 1-4 are preparing the application in antirheumatic.
6. a kind of antirheumatic spray liquid, which is characterized in that including the described in any item antirheumatic compositions of claim 1-4.
7. a kind of preparation method of antirheumatic spray liquid, which comprises the following steps:
By 0.5-3 parts of romanet grape root, 0.3-2 parts of Japanese Cayratia Herb, 0.5-2 parts of Chinese atropanthe root, 0.5-2 parts of borneol camphor tree leaf and big vast eucalyptus camphor tree leaf
0.5-2 parts of mixing, are added pharmaceutically acceptable solvent extraction；Filtering collects filtrate up to the antirheumatic spray liquid.
8. the preparation method of antirheumatic spray liquid according to claim 7, which is characterized in that the step of collecting filtrate it
Afterwards, further include the steps that wintergreen is added.
9. the preparation method of antirheumatic spray liquid according to claim 7 or 8, which is characterized in that the solvent is ethyl alcohol
Content is the rice wine of 40%-60%.
10. the preparation method of antirheumatic spray liquid according to claim 9, which is characterized in that the rice wine of addition
The ratio between weight and the total weight of drug are (12-15): 1, wherein the drug is the romanet grape root of addition, the black liana
The certain kind of berries, the Chinese atropanthe root, the borneol camphor tree leaf and the big vast eucalyptus camphor tree mixture.
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| CN110755530A (en) * | 2019-12-08 | 2020-02-07 | 怀化五零三侗医药科技开发有限公司 | Traditional Chinese medicine composition for treating cervical spondylosis and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110731996A (en) * | 2019-12-08 | 2020-01-31 | 怀化五零三侗医药科技开发有限公司 | A Chinese medicinal composition for treating rheumatic arthralgia, and its application |
| CN110755530A (en) * | 2019-12-08 | 2020-02-07 | 怀化五零三侗医药科技开发有限公司 | Traditional Chinese medicine composition for treating cervical spondylosis and application thereof |
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