CN104644933B - Relaxing tendons and activating collaterals pain-relieving Babu cream and preparation method thereof - Google Patents
Relaxing tendons and activating collaterals pain-relieving Babu cream and preparation method thereof Download PDFInfo
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- CN104644933B CN104644933B CN201510119371.6A CN201510119371A CN104644933B CN 104644933 B CN104644933 B CN 104644933B CN 201510119371 A CN201510119371 A CN 201510119371A CN 104644933 B CN104644933 B CN 104644933B
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Abstract
The present invention discloses a kind of relaxing tendons and activating collaterals pain-relieving Babu cream first comprising the matrix of the active constituents of medicine of 15 parts by weight and 30 300 parts by weight, the matrix are prepared by the raw material of following parts by weight：It is 5 80, gelatin 10 120, glycerine 60 180, ethyl hydroxy benzoate 15, Dihydroxyaluminium Aminoacetate 0.1 2, citric acid 0.05 1, ethyl alcohol 18, water 150 300 that carbomer 5 60, part, which neutralize Sodium Polyacrylate 10 90, disodium ethylene diamine tetraacetate 0.1 2, PVP K30,；Secondly the present invention discloses the preparation method of above-mentioned relaxing tendons and activating collaterals pain-relieving Babu cream, method disclosed by the invention prepares the simple for process of relaxing tendons and activating collaterals pain-relieving Babu cream, production safety, environmentally safe, and the effect of relaxing tendons and activating collaterals pain-relieving Babu cream significantly, it is small to the irritation and anaphylaxis of skin.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of Chinese medicine and preparation method thereof for relaxing tendons and activating collaterals.
Background technology
Relaxing tendons and activating collaterals pain relieving ointment (original name is Jieguling patch) is a kind of Chinese patent drug listed for many years, and prescription includes that bone is broken
The ten Six-element Chinese medicine such as benefit, teasel root, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis has the effect of promoting blood circulation and removing blood stasis, channels sootheing and network vessel quickening, swelling and pain relieving, clinically mainly
It is significant in efficacy for treating soft tissue injuries such as various closed fresh fractures and traumatic injury, bruise etc..But relaxing muscles and tendons
Active pain relieving cream is rubber ointment, and the shortcomings that dosage form is poor air permeability, big to skin irritation, allergic reaction easily occur, and
Adhesion is excessive when use, is easy adhesion chaeta, and difficult to cause to take off patch, moreover, relaxing tendons and activating collaterals pain relieving ointment is producing
It is middle to dissolve natural rubber using gasoline, therefore there is the defects of safety in production hidden danger and pollution environment.
Applicant's earlier application patent of invention of entitled " blood circulation invigorating and pain relieving adhesive plaster and preparation method thereof " (application No. is
201310653159.9), the patent of invention be based on traditional blood-activating analgesic plaster using when the drawbacks described above that equally exists and
A kind of blood circulation invigorating and pain relieving adhesive plaster and preparation method thereof is disclosed, is referred from the technical solution of the patent disclosure, applicant attempts
By the ten Six-element Chinese medicines for preparing Soothe tendons and activating-blood anodyne plaster and matrix components (i.e. card wave used by preparation blood circulation invigorating and pain relieving adhesive plaster
Nurse, PVP K30, gelatin, Sodium Polyacrylate, disodium ethylene diamine tetraacetate, glycerine, ethyl hydroxy benzoate, ethyl alcohol and water) it is combined
It to prepare relaxing tendons and activating collaterals pain-relieving Babu cream, but tests and finds, the drug extract and matrix prepared using above-mentioned technical proposal is mixed
Lotion viscoplasticity is poor after conjunction, it is difficult to be coated with, can not be molded, in other words, prepare used when same dosage form different product
Matrix components are general absolutely not.Therefore, to obtain one kind can viscosity, elasticity and mouldability it is preferable, and transdermal release
Also preferable, the prescription for the relaxing tendons and activating collaterals pain-relieving Babu cream that can safely and effectively use, this technical staff's that needs deeply grinds
Study carefully.
Invention content
The primary and foremost purpose of the present invention is to provide a kind of easy to use, good effect small to skin irritation and production safety
Relaxing tendons and activating collaterals pain-relieving Babu cream.
To achieve the goals above, present invention employs following technical schemes：A kind of relaxing tendons and activating collaterals pain-relieving Babu cream, including
The matrix of the active constituents of medicine and 30-300 parts by weight of 1-5 parts by weight, the matrix are by following parts by weight
Raw material is prepared：Carbomer 5-60, Sodium Polyacrylate 10-90, disodium ethylene diamine tetraacetate 0.1-2, PVP K30 5-
80, gelatin 10-120, glycerine 60-180, ethyl hydroxy benzoate 1-5, Dihydroxyaluminium Aminoacetate 0.1-2, citric acid 0.05-1, ethyl alcohol 1-8, water 150-
300.Preferably, the matrix is prepared by the raw material of following parts by weight：Carbomer 5-30, Sodium Polyacrylate 10-
60, disodium ethylene diamine tetraacetate 0.1-1, PVP K30 5-60, gelatin 10-80, glycerine 60-120, ethyl hydroxy benzoate 1-3, sweet
Hydroxyl aluminium 0.1-1, citric acid 0.05-0.5, ethyl alcohol 1-5, water 150-200.
Specifically, the active constituents of medicine is prepared by the raw material of following parts by weight：Rhizome of davallia 7-11, continue
Disconnected 7-11, ground bettle 4-8, Rhizoma Et Radix Notopterygii 7-11, rhizoma arisaematis 7-11, frankincense 1-5, myrrh 1-5, Radix Angelicae Sinensis 7-11, peach kernel 4-5, cortex acanthopanacis
7-11, dandelion 7-11, safflower 7-11, borneol 0.5-1.5, camphor 1-3, gaultherolin 1-2, eucalyptus oil 0.5-1.5, here institute
The sixteen bit bulk pharmaceutical chemicals stated that is to say that (number is the 13rd Jieguling patch standard of the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation
WS3-B-2609-97 the bulk pharmaceutical chemicals described in prescription), although relaxing tendons and activating collaterals pain-relieving Babu cream disclosed by the invention with
The drug component of existing relaxing tendons and activating collaterals pain relieving ointment (i.e. Jieguling patch) is identical, but the content of each bulk pharmaceutical chemicals and is prepared into
To the using effect of product really there is larger difference.
The parts by weight of scheme as a further preference, each raw material are：The rhizome of davallia 9, teasel root 9, ground bettle 6, Qiang
Live 9, rhizoma arisaematis 9, frankincense 3, myrrh 3, Radix Angelicae Sinensis 9, peach kernel 4.5, cortex acanthopanacis 9, dandelion 9, safflower 9, borneol 1, camphor 2, bigcatkin willow
Sour methyl esters 1.5, eucalyptus oil 1, carbomer 10, Sodium Polyacrylate 20, disodium ethylene diamine tetraacetate 0.1, PVP K30 20, gelatin
15, glycerine 100, ethyl hydroxy benzoate 3, Dihydroxyaluminium Aminoacetate 1, citric acid 1, ethyl alcohol 5, water 150.Experiment proves, defined by above-mentioned parameter
The stability and using effect for the relaxing tendons and activating collaterals pain-relieving Babu cream that constituent content is prepared are more preferably.Preferably, described poly-
Sodium acrylate is that part neutralizes Sodium Polyacrylate, is divided according to model in the market, and Sodium Polyacrylate is divided into poly- partly to neutralize
Sodium acrylate and complete neutralization Sodium Polyacrylate, experiment proves, compared with complete neutralization Sodium Polyacrylate, the present invention selects part
It neutralizes Sodium Polyacrylate and has the advantages of the following aspects as one of raw material preparation relaxing tendons and activating collaterals pain-relieving Babu cream：1) part
Neutralizing Sodium Polyacrylate has higher Efficient Adhesive Promotion, and the viscosity reduction after dilution is less, and it is poly- to add a small amount of part neutralization
Sodium acrylate can make the product of preparation that can notice repeatedly, and using effect is good；2) storage stability higher, part neutralize polypropylene
The addition of sour sodium has the ongoing change of viscosity certain inhibiting effect；3) when neutralizing Sodium Polyacrylate using part, even if
Under acidic environment, relaxing tendons and activating collaterals pain-relieving Babu cream also has good using effect.
The present invention is using carbomer, Sodium Polyacrylate, disodium ethylene diamine tetraacetate, PVP K30, gelatin, glycerine, oxybenzene
Ethyl ester, Dihydroxyaluminium Aminoacetate, citric acid and the ethyl alcohol foundation that totally ten taste auxiliary materials are used to prepare relaxing tendons and activating collaterals pain-relieving Babu cream is：
1) carbomer, PVP K30, gelatin and Sodium Polyacrylate have played the effect of adhesive jointly, greatly enhance
The stability of system, specifically, the present invention with the glossiness of product, hold viscous force, take off patch property, matrix residual and skin repeatedly
Tracing ability is performance indicator, and the best of carbomer, PVP K30, gelatin and Sodium Polyacrylate is preferably gone out by orthogonal test and is matched
Than, it is scientific and reasonable, using the cream face for the relaxing tendons and activating collaterals pain-relieving Babu cream that raw material disclosed by the invention and proportion relation are prepared
Bright and clean, adhesion is moderate, matrix noresidue, can take off patch repeatedly, and skin tracing ability is preferable；
2) glycerine has given full play to moisture-keeping function, with carbomer with Hydrogenbond, to effectively reinforce the stabilization of matrix
Property；
3) ethyl hydroxy benzoate can effectively inhibit relaxing tendons and activating collaterals pain-relieving Babu cream mould growth as bacteriostatic agent.
4) Dihydroxyaluminium Aminoacetate can be protected effectively as crosslinking agent, disodium ethylene diamine tetraacetate and citric acid as cross-linking regulator
The relaxing tendons and activating collaterals pain-relieving Babu cream of the card present invention has good cohesive force, and then ensures that relaxing tendons and activating collaterals pain-relieving Babu cream is added
Work is molded.
5) ethyl alcohol dissolves fat-soluble ingredient as solvent, improves the drug effect of drug.
Another object of the present invention is to provide a kind of preparation method of above-mentioned relaxing tendons and activating collaterals pain-relieving Babu cream, including with
Lower step：
S1)：The water that 8-15 times of weight is separately added into ground bettle, peach kernel decocts, and merges the decoction of ground bettle, peach kernel
Liquid, filtration, filtrate is condensed into the water that relative density is 1.25-1.27g/ml, and to carry thick paste spare；
S2)：By the rhizome of davallia, teasel root, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, rhizoma arisaematis, safflower, dandelion, frankincense, myrrh and cortex acanthopanacis this ten
Taste bulk pharmaceutical chemicals co-grinding obtain mixing coarse powder, to mixing coarse powder in be added 8-15 times of weight, a concentration of 85-95% ethyl alcohol into
Row diacolation, collection are filtered liquid, and recycling ethyl alcohol is simultaneously concentrated into the alcohol extracting thick paste that relative density is 1.05-1.15g/ml, by alcohol extracting thick paste,
Water made from borneol, camphor, gaultherolin, eucalyptus oil and step S1 proposes thick paste mixing and stirs evenly, and obtains drug extract；
S3)：Carbomer is neutralized Sodium Polyacrylate with part to mix, glycerine stirring is added, adding water makes mixture be swollen,
Obtain matrix I；
S4)：Disodium ethylene diamine tetraacetate is weighed, is dissolved in water, is added after PVP K30 and gelatin are mixed, in 50-80
It is dissolved by heating under conditions of DEG C, obtains matrix II, matrix I made from matrix II and step S3 mixed, under conditions of 50-80 DEG C
0.5-2h is stirred, matrix III is obtained；
S5)：Water intaking is appropriate, respectively adding citric acid and Dihydroxyaluminium Aminoacetate, stirs 10-30min, then by citric acid and Dihydroxyaluminium Aminoacetate
Lysate is all added to mixing in matrix III, obtains matrix IV；
S6)：Weigh ethyl hydroxy benzoate, dissolved with ethanol in proper amount, then be added matrix IV stir 10-30min, then with step S2
Drug extract obtained presses 30-50:1 mass ratio mixing, stir 0.5-1.5h, be coated with while hot it is compound, in relative humidity 20-
40%, up to product after temperature is dry under conditions of being 20-40 DEG C, each bulk pharmaceutical chemicals involved in above step S1-S6 according to
The parts by weight of foregoing description weigh.
Specifically scheme is：Heating for dissolving temperature in the step S4 is 60-70 DEG C, after matrix I and the mixing of matrix II
It is to stir 0.5-1h under conditions of 60-70 DEG C；Citric acid in the step S5, Dihydroxyaluminium Aminoacetate the stirring and dissolving time be 10-
20min；Mixing time in the step S6 is 0.5-1h；Concentration of alcohol used in the step S2 and S4 is 90%.
The relaxing tendons and activating collaterals pain relieving ointment prepared using the above method has the advantages of the following aspects：
(1) drug easily absorbs：Compared with the relaxing tendons and activating collaterals pain relieving ointment of the prior art, relaxing tendons and activating collaterals pain-relieving Babu of the invention
The moisture contained in cream is more, therefore while using can make the cuticula of human skin be easy softening, utilize the absorption of drug, treat
Effect is notable；
(2) small to the irritation of skin and anaphylaxis：Natural rubber used in prior art preparation relaxing tendons and activating collaterals pain relieving ointment
In contain plurality of impurities, easily cause skin allergy, in contrast, the present invention relaxing tendons and activating collaterals pain-relieving Babu cream eliminate natural rubber
The use of glue, effectively reduces product to skin irritation and anaphylaxis, using comfortable, improves the compliance of patient；
(3) drug effect is notable：The prior art mainly uses gasoline to prepare relaxing tendons and activating collaterals pain relieving ointment as solvent, and relaxing tendons and activating collaterals stops
Technological temperature when pain cream is molded is higher, causes effective volatile ingredient in drug to lose, influences drug effect, and of the present invention
The molding of relaxing tendons and activating collaterals pain-relieving Babu cream when be not necessarily to hot conditions, so not only saving heat energy, but also drug can be substantially reduced
The volatilization or loss of active ingredient, to improve the drug effect of product；
(4) adhesion strength is stronger：Compared with other existing disclosed Babu cream Chinese medicines, relaxing tendons and activating collaterals analgesic disclosed by the invention
The adhesion strength of Babu cream is stronger, specific adhesion test the result shows that, relaxing tendons and activating collaterals pain-relieving Babu cream disclosed by the invention can glue
Firmly No. 20 steel balls, therefore without additional fixed when use；
(5) environment is small, production safety for pollution：It is disclosed by the invention to relax compared with the production technology of relaxing tendons and activating collaterals pain relieving ointment
Muscle active pain relieving Babu cream makees solvent without gasoline, thus can reduce environmental pollution, improves the safety of production；
(6) simple for process, easy to use：Using method disclosed by the invention prepare relaxing tendons and activating collaterals pain-relieving Babu cream easily
Molding, specifically, drug extract can be mixed uniformly after being mixed with host material, the relaxing tendons and activating collaterals obtained after coated drying
Pain-relieving Babu cream has good biocompatibility between skin in use, can take off patch repeatedly, and elasticity is good, uses
It is very convenient.
The meridian distribution of property and flavor of the raw materials used in the present invention, major function, main component and pharmacological action are as follows：
The rhizome of davallia：Bitter, temperature, Return liver kidney channel；It cures the wound analgesic, The strong bone of kidney tonifying；For falling winks frustrates, injured bone, kidney deficiency waist
Bitterly, muscles and bones impotence, Hiccough and deaf, tooth mobility；For monarch drug in a prescription in side, main component has starch, glucose, naringin
(Naringin)；Some researches show that the rhizome of davallia plays the role of bone articular cartilage to stimulate compensatory cellular hyperplasia, and can partly change
It is kind to cause bone joint degeneration since mechanical stress line changes, to reduce the lesion rate of osteoarthropathy.
Teasel root：Bitter, pungent, slightly warm in nature；Enter liver and kidney channel.Filling liver kidney, adjusts blood vessels at continuous muscles and bones；For aching pain in waist and back, sufficient knee
Inability, threatened abortion, uterine bleeding, band under, seminal emission, traumatic injury, metal-inflicted wound, anal fistula, ulcer sore swells；Main component has alkaloid, volatile oil；
Pharmacological research shows that teasel root water decoction has stronger excitation to rabbit isolated uterine, shows as frequency increase, tension raising,
It is in tetanic contraction state more.
Ground bettle：It is salty, it trembles with fear, it is slightly poisonous；Return liver warp；Dissipating blood stasis with potent drugs, reunion of fractured tendons and bones；For traumatic injury, injury of tendon and muscle fracture, blood
Stasis of blood Amenorrhea, postpartum stasis abdominal pain, abdominal mass lump in the abdomen.
Peach kernel：It is bitter, sweet, it is mild-natured；Enter the heart, liver, large intestine channel.The silt of blood-breaking row, moisturize laxation；Cure mainly Amenorrhea, Disorder lumps in the abdomen, pyreticosis
Store blood, wandering arthritis, malaria, traumatic injury, extravasated blood swelling and pain, the dry constipation of blood；Main component has amygdalin (Amygdalin), bitter apricot
Benevolence enzyme (Emulsin), allantoinase (Allantoinase), lactase (Lactase), vitamin B1, volatile oil, fat oil.
Pharmacological action：(1) 500% peach kernel extracting solution is injected intravenously to anesthetized rabbit, can increase rabbit cerebral blood flow (CBF) immediately, reduces cerebrovascular resistance
Power；It is injected to mouse peritoneal, mouse ear blood vessel dilatation can be made rubescent, have report to point out, peach kernel has certain anticoagulation, can carry
CAMP is horizontal in high blood platelet, inhibits blood clotting.Clinical observation proves that peach kernel blocks blood flow, blood obstacle has improvement to make
With each internal organs each group capable of being made to knit functional recovery normal.(2) zoopery proves that peach kernel has promotion inflammation absorption, to inflammation
There is stronger anti-transudation at initial stage, but anti-granulation formation effect is weaker, and the amygdalin in peach kernel also has anti-inflammatory effect, right
The analgesic activity of Experimental Inflammation is the 1/2 of aminopyrine；To the inhibiting effect of granuloma method or carrageenan vola pedis oedema method
It is the 1/2 of phenylbutazone；Also there is identical effect to heated aqueous vola pedis oedema.Zoopery proves：The oral effect of amygdalin
Fruit is most strong, and intraperitoneal injection is taken second place, and intravenous injection is almost inactive.(3) peach kernel has anti-allergic effects, water extract that can inhibit small
The generation of skin-sensitizing antibodies and house mouse spleen hemolytic cell in mouse serum.Its ethanol extract is oral, mouse can be inhibited to contain
There is the pigment seepage discharge of passive cutaneous anaphylaxis caused by the antiserum of anaphylactic antibody.Clinical observation is found, is to rash block
Carry purple in red, i.e. prompt has a contact dermatitis of systemic skin stagnation of the blood tendency symptom, peach kernel be whether applied alone or with
Other drugs share, and have particularly apparent therapeutic effect, symptom can be made to be improved quickly.
Safflower：Acrid flavour, it is warm-natured；Enter the heart, Liver Channel；Invigorate blood circulation, going to become silted up relieves pain；Cure mainly Amenorrhea, Disorder lumps in the abdomen, difficult labour, stillborn foetus, production
Afterwards lochia, extravasated blood have a pain, carbuncle swells, injury from falling down；Main component has safflower quinone glucoside (Carthamone), neocarthamin
(Neocarthamin), carthamin (Carthamin)；Carthamin hydrolyzes to obtain glucose (Glucose) and carthamin
(Carthamidin)；Pharmacological action：Safflower can be such that whole blood clotting time and blood plasma recalcification time significantly extends, and divide from safflower
The active ingredient carthamin yellow separated out has and inhibits platelet aggregation, increases Fibrinolysin activity, inhibits external blood
The effects that bolt formation, carthamin yellow have calm, analgesia and anticonvulsant action.Hot plate method in mice and acetic acid twisting experiments have shown that：It is red
Anthoxanthin has analgesic activity, and can enhance the central inhibitory action of barbital and chloraldurate, reduces nikethamidum and faints from fear
Reactivity and the death rate.50% methanol of safflower and water extract can inhibit the foot swelling caused by carrageenan, it is prompted to have
Anti-inflammatory effect.Safflor yellow also has immunosuppressive action, and it is white to reduce serum lysozyme content, peritoneal macrophage and whole blood
The phagocytic function of cell.
Radix Angelicae Sinensis：Sweet, acrid, warm, Return liver, the heart, the spleen channel, replenishing and activating blood, menstruction regulating and pain relieving relax bowel, and are used for blood deficiency chlorosis, dizzy
Dizzy palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sores, dry constipation of intestines；Prepared RADIX ANGELICAE SINENSIS with yellow rice wine
Invigorate blood circulation is used for closed dysmenorrhea, arthralgia pain due to rheumatism, injury from falling down.Volatile oil, Ligustilide, positive butyryl lactone are mainly contained,
And ferulic acid, polysaccharide, grease-like composition.Pharmacological research shows that the effect of macrophage can be remarkably reinforced in Radix Angelicae Sinensis, and Radix Angelicae Sinensis is more
Sugar can enhance the humoral immune function of body, have stronger activation to T lymphocytes, have to human spleen cell and promote have silk
Mitotic activity, four allergic reaction type of Radix Angelicae Sinensis ferulic acid pair have inhibiting effect.
Frankincense：Acrid, bitter, warm, the thoughts of returning home, liver, the spleen channel, analgesic therapy of invigorating blood circulation, detumescence and promoting granulation are used for chest impediment and cardialgia, gastral cavity pain, pain
Through Amenorrhea, postpartum stasis , Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, muscle arteries and veins contraction, traumatic injury, carbuncle swells sore.Mainly contain five rings three
The ingredients such as terpene, tetracyclic triterpene, macrocyclic diterpene class, volatile oil, arabinose, xylose, galactolipin, sitosterol and tan acid anhydride.Frankincense carries
It takes object that there is significant anti-inflammatory effect, boswellic acids derivatives can significantly reduce the quantity of leucocyte in rabbit knee synovia, and is in agent
Correlation is measured, frankincense powder, water extract and alcohol extract have significant detumescence effect to blood stasis swelling caused by wound.
Myrrh：It is pungent, bitter, it puts down, the thoughts of returning home, liver, the spleen channel, scattered stasis pain, detumescence and promoting granulation, is used for chest impediment and cardialgia, gastral cavity pain, pain
Through Amenorrhea, postpartum stasis , Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, traumatic injury, carbuncle swells sore, with the pharmacological actions such as analgesia, anti-inflammatory.
Mainly contain the ingredients such as volatile oil, resin, natural gum, salt.Furans eudesmane -1,3- the diene and curzerene wherein contained has
Analgesic activity, the inflammation and granuloma that petroleum ether component induces carrageenan have significant inhibiting effect, C.wightii oil
Fat has inhibiting effect to lipopolysaccharide-induced NO synthesis, and the bioactive ingredients obtained from C.wightii can be used for treating bone
Folding, arthritis and inflammation etc. there are not powdered medicine, water extract and alcohol extract to have significant detumescence to make blood stasis swelling caused by wound
With.
Rhizoma arisaematis：It is bitter, pungent, it is warm-natured.It is toxic.Enter lung, liver, the spleen channel.Eliminating dampness and eliminating phlegm, dispelling wind and relieving convulsion, dispersing swelling and dissipating binds.For
Heap soil or fertilizer over and around the roots of apoplexy phlegm, mouth eye are oblique, hemiplegia, epilepsy, infantile convulsion, lockjaw, anemophlegmatic vertigo, larynx numbness, scrofula, carbuncle swells, fall and flutter injured, snake
Insect bite.Main component has, triterpenoid saponin, PEARLITOL 25C, benzoic acid, starch etc..Pharmacological action：Rhizoma arisaematis decoction is to rat
It is injected intraperitoneally with rabbit, its activity reduction, peace and quiet, righting reflex can be made blunt.It can significantly extend hexamethylene to mouse peritoneal injection
The sleeping time of barbital sodium；Also there is apparent analgesic effect (hot plate method).Rhizoma arisaematis has anticonvulsant action.
Cortex acanthopanacis：Acrid flavour, hardship, it is warm-natured.Enter liver and kidney channel.Wind-damp dispelling strengthens the bone, invigorates blood circulation and go to become silted up.For wind-cold-dampness arthralgia, muscle
Bone contraction urgency, pain in the back, impotence, flaccidity of lower limbs, children's retardation of walking, oedema, tinea pedis, sore subcutaneous ulcer pyogenic infections, bruise, internal lesion caused by overexertion.Main component has, volatilization
Oil, tannin, palmitic acid, leukotrienes and vitamin A and vitamin B1.Pharmacological action：Nothing is produced in analgesia, antipyretic, anti-inflammatory effect, Liaoning
The root skin for obstructing slender acanthopanax extracts its non-degreasing preparation and degreasing preparation with ethyl alcohol, and mouse peritoneal, which is injected, analgesic activity, but compared with
Coffee mitigates, but to rabbit experiment without refrigeration function.Both preparations have inhibition to rat egg white and formaldehyde " arthritis "
Effect, effect is similar to the effect of cortisone, therefore has report to think that the anti-inflammatory effect of Panax sessiliflorus and adrenal gland have closely
Relationship.Experiment shows：Produce Panax sessiliflorus alcohol extracting thing Carrageenan, egg white, blanching, formaldehyde rat, mouse foot in Jilin
Swelling, the exudation of croton oil air cyst and granulation tissue hyperplasia have apparent inhibiting effect, and significantly inhibit adjuvant (6mg fast knots
Core bacillus/ml) arthritis and I, II, type Ⅲ allergy inflammation.There is apparent antipyretic, analgesic activity simultaneously.
Rhizoma Et Radix Notopterygii：Acrid flavour, hardship, it is warm-natured.Enter bladder, kidney channel.Relieving exterior syndrome and dispelling cold, expelling wind and eliminating dampness, easing joint movement, analgesic.For feeling
Emit chill, headache and adiapneustia, wind-cold-dampness arthralgia, item strengthening tendons urgency, joint ache, geomantic omen edema, skin sore.Main component has, volatilization
Oil, ferulic acid, rhamnose, fructose, glucose, 17 kinds of amino acid such as sucrose (Sucrose) and lysine, arginine.Medicine
Reason acts on：Antipyretic, analgesic activity, Rhizoma Et Radix Notopterygii volatile oil gavage or intraperitoneal injection, can be such that pyrogenicity rat temperature is substantially reduced, have
Significant refrigeration function；Mouse Rhizoma Et Radix Notopterygii volatile oil, then the acetum of row intraperitoneal injection 0.5% are given for three days on end, it is seen that Rhizoma Et Radix Notopterygii
Volatile oil can be such that mouse writhing number significantly reduces, and have significant analgesic activity.Experiment shows：2% Rhizoma Et Radix Notopterygii injection 10ml/kg
40 minutes after intraperitoneal injection, the mouse threshold of pain significantly improves.
Dandelion：It is bitter, sweet, it is cold in nature.Enter liver, stomach.Clearing heat and detoxicating, diuresis, dissipating bind.For acute mastitis, lymph
Tie inflammation, scrofula, boil poisonous soreness, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, courage
Capsulitis, urinary tract infections.Main component has, taraxasterol, choline, synanthrin, pectin, taraxol, stigmasterol, β-botany bar gum
Alcohol, cupreol, taraxerol, taraxacin, taraxacin and vitamin A, B, C etc..Pharmacological action：Dandelion is injected
Liquid in vitro has stronger bactericidal effect to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus.Dandelion decoction exists
Human peripheral lymphocyte blast transformation rate can be significantly improved in vitro.It is anti-that Taraxacum Polysaccharides intraperitoneal injection can significantly increase mouse
The cytotoxicity of body dependence macrophage.
Specific implementation mode
Disclosed technical solution in order to further illustrate the present invention illustrates below by way of 7 embodiments：
Embodiment 1：The preparation of relaxing tendons and activating collaterals pain-relieving Babu cream
1) raw material of following parts by weight is weighed respectively：The rhizome of davallia 7, teasel root 7, ground bettle 4, Rhizoma Et Radix Notopterygii 7, rhizoma arisaematis 7, frankincense
1, myrrh 1, Radix Angelicae Sinensis 7, peach kernel 5, cortex acanthopanacis 7, dandelion 7, safflower 7, borneol 0.5, camphor 1, gaultherolin 1, eucalyptus oil 0.5,
Carbomer 5, part neutralize Sodium Polyacrylate 10, disodium ethylene diamine tetraacetate 0.1, PVP K30 5, gelatin 10, glycerine 60,
Ethyl hydroxy benzoate 1, Dihydroxyaluminium Aminoacetate 0.1, citric acid 0.05, ethyl alcohol 1, water 150；
2) water that 8 times of weight is separately added into ground bettle, peach kernel decocts, merge ground bettle, peach kernel decoction liquor, filter
It crosses, filtrate, which is condensed into the water that relative density is 1.25g/ml, carries thick paste, by the rhizome of davallia, teasel root, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, rhizoma arisaematis, red
This ten tastes bulk pharmaceutical chemicals co-grinding of flower, dandelion, frankincense, myrrh and cortex acanthopanacis obtains mixing coarse powder, and 8 are added into mixing coarse powder
Times weight, a concentration of 95% ethyl alcohol carry out diacolation, collection is filtered liquid, and it is 1.05g/ml's that recycling ethyl alcohol, which is simultaneously concentrated into relative density,
Water is proposed thick paste, alcohol extracting thick paste, borneol, camphor, gaultherolin and eucalyptus oil mixing and stirred evenly, obtains drug extract by alcohol extracting thick paste；
3) carbomer is neutralized Sodium Polyacrylate with part to mix, glycerine stirring is added, adding water makes mixture be swollen, and obtains
Matrix I weighs disodium ethylene diamine tetraacetate, is dissolved in water, and is added after PVP K30 and gelatin are mixed, in 50 DEG C of condition
Lower heating for dissolving 2h, obtains matrix II, and matrix I and matrix II are mixed, and stirs 2h under conditions of 50 DEG C, obtains matrix III；
4) water intaking is appropriate, respectively adding citric acid and Dihydroxyaluminium Aminoacetate, 10min is stirred, then by the dissolving of citric acid and Dihydroxyaluminium Aminoacetate
Liquid is all added to mixing in matrix III, obtains matrix IV；
5) weigh ethyl hydroxy benzoate, dissolved with ethanol in proper amount, then be added matrix IV stir 10min, then with made from step 2
Drug extract presses 30：1 mass ratio mixing, stirs 1.5h, is coated with while hot compound, is 20 DEG C in relative humidity 20%, temperature
Under the conditions of it is dry after up to relaxing tendons and activating collaterals pain-relieving Babu cream, detected through adhesion strength, which can stick 20
Number steel ball.
Embodiment 2：The preparation of relaxing tendons and activating collaterals pain-relieving Babu cream
1) raw material of following parts by weight is weighed respectively：The rhizome of davallia 11, teasel root 11, ground bettle 8, Rhizoma Et Radix Notopterygii 11, rhizoma arisaematis 11,
Frankincense 5, myrrh 5, Radix Angelicae Sinensis 11, peach kernel 5, cortex acanthopanacis 11, dandelion 11, safflower 11, borneol 1.5, camphor 3, gaultherolin 2,
Eucalyptus oil 1.5, carbomer 60, part neutralize Sodium Polyacrylate 90, disodium ethylene diamine tetraacetate 2, PVP K30 80, gelatin
120, glycerine 180, ethyl hydroxy benzoate 5, Dihydroxyaluminium Aminoacetate 2, citric acid 1, ethyl alcohol 8, water 300；
2) water that 15 times of weight is separately added into ground bettle, peach kernel decocts, merge ground bettle, peach kernel decoction liquor, filter
It crosses, filtrate, which is condensed into the water that relative density is 1.26g/ml, carries thick paste, by the rhizome of davallia, teasel root, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, rhizoma arisaematis, red
This ten tastes bulk pharmaceutical chemicals co-grinding of flower, dandelion, frankincense, myrrh and cortex acanthopanacis obtains mixing coarse powder, is added into mixing coarse powder
15 times of weight, a concentration of 95% ethyl alcohol carry out diacolation, collection is filtered liquid, and it is 1.15g/ml that recycling ethyl alcohol, which is simultaneously concentrated into relative density,
Alcohol extracting thick paste, water is carried into thick paste, alcohol extracting thick paste, borneol, camphor, gaultherolin and eucalyptus oil are mixed and stirred evenly, obtains drug leaching
Cream；
3) carbomer is neutralized Sodium Polyacrylate with part to mix, glycerine stirring is added, adding water makes mixture be swollen, and obtains
Matrix I weighs disodium ethylene diamine tetraacetate, is dissolved in water, and is added after PVP K30 and gelatin are mixed, in 80 DEG C of condition
Lower heating for dissolving, obtains matrix II, and matrix I and matrix II are mixed, and stirs 0.5h under conditions of 85 DEG C, obtains matrix III；
4) water intaking is appropriate, respectively adding citric acid and Dihydroxyaluminium Aminoacetate, 30min is stirred, then by the dissolving of citric acid and Dihydroxyaluminium Aminoacetate
Liquid is all added to mixing in matrix III, obtains matrix IV；
5) weigh ethyl hydroxy benzoate, dissolved with ethanol in proper amount, then be added matrix IV stir 30min, then with made from step 2
Drug extract presses 50：1 mass ratio mixing, stirs 1h, is coated with while hot compound, is 50 DEG C of item in relative humidity 50%, temperature
It is detected through adhesion strength, which can stick No. 26 up to relaxing tendons and activating collaterals pain-relieving Babu cream after drying under part
Steel ball.
Embodiment 3：The preparation of relaxing tendons and activating collaterals pain-relieving Babu cream
1) raw material of following parts by weight is weighed respectively：The rhizome of davallia 9, teasel root 9, ground bettle 6, Rhizoma Et Radix Notopterygii 9, rhizoma arisaematis 9, frankincense
3, myrrh 3, Radix Angelicae Sinensis 9, peach kernel 4.5, cortex acanthopanacis 9, dandelion 9, safflower 9, borneol 1, camphor 2, gaultherolin 1.5, eucalyptus oil 1,
Carbomer 10, part neutralize Sodium Polyacrylate 20, disodium ethylene diamine tetraacetate 0.1, PVP K30 20, gelatin 15, glycerine
100, ethyl hydroxy benzoate 3, Dihydroxyaluminium Aminoacetate 1, citric acid 1, ethyl alcohol 5, water 200；
2) water that 10 times of weight is separately added into ground bettle, peach kernel decocts, merge ground bettle, peach kernel decoction liquor, filter
It crosses, filtrate, which is condensed into the water that relative density is 1.26g/ml, carries thick paste, by the rhizome of davallia, teasel root, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, rhizoma arisaematis, red
This ten tastes bulk pharmaceutical chemicals co-grinding of flower, dandelion, frankincense, myrrh and cortex acanthopanacis obtains mixing coarse powder, is added into mixing coarse powder
10 times of weight, a concentration of 90% ethyl alcohol carry out diacolation, collection is filtered liquid, and it is 1.1g/ml that recycling ethyl alcohol, which is simultaneously concentrated into relative density,
Alcohol extracting thick paste, water is carried into thick paste, alcohol extracting thick paste, borneol, camphor, gaultherolin and eucalyptus oil are mixed and stirred evenly, obtains drug leaching
Cream；
3) carbomer is neutralized Sodium Polyacrylate with part to mix, glycerine stirring is added, adding water makes mixture be swollen, and obtains
Matrix I weighs disodium ethylene diamine tetraacetate, is dissolved in water, and is added after PVP K30 and gelatin are mixed, in 60 DEG C of condition
Lower heating for dissolving, obtains matrix II, and matrix I and matrix II are mixed, and stirs 1.5h under conditions of 65 DEG C, obtains matrix III；
4) water intaking is appropriate, respectively adding citric acid and Dihydroxyaluminium Aminoacetate, 20min is stirred, then by the dissolving of citric acid and Dihydroxyaluminium Aminoacetate
Liquid is all added to mixing in matrix III, obtains matrix IV；
5) weigh ethyl hydroxy benzoate, dissolved with ethanol in proper amount, then be added matrix IV stir 20min, then with made from step 2
Drug extract presses 40：1 mass ratio mixing, stirs 1h, is coated with while hot compound, is 30 DEG C of item in relative humidity 30%, temperature
It is detected through adhesion strength, which can stick No. 24 up to relaxing tendons and activating collaterals pain-relieving Babu cream after drying under part
Steel ball.
Embodiment 4：Influence of the relaxing tendons and activating collaterals pain-relieving Babu cream of the present invention to mouse caused by dimethylbenzene xylene inflammation
Male and healthy mouse 36 is chosen, is randomly divided into 3 groups, respectively control group, relaxing tendons and activating collaterals pain relieving ointment group, relaxing muscles and tendons is lived
Network pain-relieving Babu cream group, every group 12, each experimental mice sticks ointment 1 time in auris dextra daily, 3 times continuous, after the last administration
1h removes emplastrum, and auris dextra applies dimethylbenzene 0.05mL/ only, and left ear compares, and mouse is put to death after 15min, with the punching of diameter 7mm
Device cuts ears with position homalographic, weighs respectively, calculates auris dextra swelling.The results show that the relaxing tendons and activating collaterals of the prior art
No significant difference between pain relieving ointment group and the relaxing tendons and activating collaterals pain-relieving Babu cream group of the present invention, it is as shown in Table 1 below.
1 paraxylene of table cause mice ear influence (n=12,)
Compared with the control group：* p ＜ 0.05
Embodiment 5：Influence of the relaxing tendons and activating collaterals pain-relieving Babu cream of the present invention to mouse hot-plate induced pain
The temperature of thermostatic water-circulator bath is adjusted at 55 DEG C ± 0.5 DEG C, hot plate is preheated into 10min, takes female healthy mice, often
Secondary 1 is merely placed on hot plate, and mouse is from being placed on the hot plate pain threshold of (s) as the mouse the time required to there is licking metapedes.It is all to lick
The metapedes time is less than 5s or is more than 30s or leaper, gives it up, and 36 qualified mouse are randomly divided into control group, relaxing muscles and tendons
Active pain relieving cream group, relaxing tendons and activating collaterals pain-relieving Babu cream group, every group 12, each experimental mice sticks ointment 1 time in back leg daily,
Continuous 3 times, 1h, measures the pain threshold of mouse after the last administration.The results show that the relaxing tendons and activating collaterals pain relieving ointment group of the prior art and sheet
No significant difference between the relaxing tendons and activating collaterals pain-relieving Babu cream group of invention, it is as shown in Table 2 below.
Table 2 to mouse hot-plate induced pain pain threshold influence (n=12,)
Compared with the control group：* p ＜ 0.05
Embodiment 6：The relaxing tendons and activating collaterals pain-relieving Babu cream Dichlorodiphenyl Acetate of the present invention causes the influence of mouse writhing
Male and healthy mouse 36 is chosen, is randomly divided into 3 groups, respectively control group, relaxing tendons and activating collaterals pain relieving ointment group, relaxing muscles and tendons is lived
Network pain-relieving Babu cream group, shaves off mouse web portion hair by every group 12 before experiment, mouse web portion be administered, repeated respectively after 1 hour to
Medicine is primary, and 0.6% acetum 0.1mL/10g is injected intraperitoneally immediately after, observes the writhing response of mouse, with typical hind leg
Stretching, extension, abdomen distortion, contraction of abdominal muscle is standard, records the writhing number of each group animal in 15min.The results show that the prior art
Relaxing tendons and activating collaterals pain relieving ointment group and the present invention relaxing tendons and activating collaterals pain-relieving Babu cream group between no significant difference, refer to table
Shown in 3.
Table 3 to mouse acetic acid induced pain writhing number influence (n=12,)
Compared with the control group：* p ＜ 0.01
Conclusion：The relaxing tendons and activating collaterals pain relieving ointment group of the prior art and the relaxing tendons and activating collaterals pain-relieving Babu cream group of the present invention have obviously
Anti-inflammatory and analgesic effect, although the no significant difference of the two anti-inflammatory and analgesic effect, in use, the present invention relaxing muscles and tendons live
Network pain-relieving Babu cream is more rapid-action than the relaxing tendons and activating collaterals pain relieving ointment of the prior art, and has no apparent irritation and allergic reaction,
Docile is comfortable, and production security is high, and environmental pollution is low.In addition, using rabbit to the present invention relaxing tendons and activating collaterals pain-relieving Babu cream into
Go acute toxicity test, the results showed that, it is anti-that the rabbit of intact skin group and damaged skin group is showed no apparent general toxicity
It answers.
Embodiment 7：Irritation test of the relaxing tendons and activating collaterals pain-relieving Babu cream of the present invention to skin
It takes healthy rabbits (2.3 ± 0.2kg) 12, half male and half female to be divided into intact skin group and damaged skin group, is being administered
First 48 hours, back part of animal vertebra both sides are lost hair or feathers with 6% sodium sulfide solution, are about 50cm per lateral area2, 24 hours after unhairing
It is injured due to unhairing to check whether skin of unhairing has, the damaged skin of rabbit is produced as follows：Unhairing is sterilized into skin with scalpel
Skin scratches, and is degree with oozing of blood, and the damaged degree of control left and right sides skin is consistent substantially.
Experiment is using androgynous left and right Self-control method：Relaxing tendons and activating collaterals pain-relieving Babu cream and sky are given respectively in left and right sides unhairing area
Primary, successive administration 7 days is smeared in white control daily；1,24,48,72 hour observation medicine-feeding part has after stopping being administered respectively
Without erythema and situations such as oedema, while paying attention to observing whether medicine-feeding part has situations such as pigmentation, blutpunkte, pachylosis.
The result shows that relaxing tendons and activating collaterals pain-relieving Babu cream successive administration is observed after 7 days in 72 hours, rabbit intact skin group and breakage
Skin group is showed no the irritative responses such as erythema, oedema.
Claims (9)
1. a kind of relaxing tendons and activating collaterals pain-relieving Babu cream, it is characterised in that：Active constituents of medicine including 1-5 parts by weight and 30-300
The matrix of parts by weight, the matrix are prepared by the raw material of following parts by weight：Carbomer 5-60, Sodium Polyacrylate
10-90, disodium ethylene diamine tetraacetate 0.1-2, PVP K30 5-80, gelatin 10-120, glycerine 60-180, ethyl hydroxy benzoate 1-
5, Dihydroxyaluminium Aminoacetate 0.1-2, citric acid 0.05-1, ethyl alcohol 1-8, water 150-300；The active constituents of medicine is by following parts by weight
Several raw materials are prepared：Rhizome of davallia 7-11, teasel root 7-11, ground bettle 4-8, Rhizoma Et Radix Notopterygii 7-11, rhizoma arisaematis 7-11, frankincense 1-5, do not have
Medicine 1-5, Radix Angelicae Sinensis 7-11, peach kernel 4-5, cortex acanthopanacis 7-11, dandelion 7-11, safflower 7-11, borneol 0.5-1.5, camphor 1-3, water
Poplar acid methyl esters 1-2, eucalyptus oil 0.5-1.5.
2. relaxing tendons and activating collaterals pain-relieving Babu cream according to claim 1, it is characterised in that：The matrix is by following weight
The raw material of number is prepared：Carbomer 5-30, Sodium Polyacrylate 10-60, disodium ethylene diamine tetraacetate 0.1-1, PVP K30
For 5-60, gelatin 10-80, glycerine 60-120, ethyl hydroxy benzoate 1-3, Dihydroxyaluminium Aminoacetate 0.1-1, citric acid 0.05-0.5, ethyl alcohol 1-5, water
150-200。
3. relaxing tendons and activating collaterals pain-relieving Babu cream according to claim 1, it is characterised in that：The parts by weight of each raw material
For：The rhizome of davallia 9, teasel root 9, ground bettle 6, Rhizoma Et Radix Notopterygii 9, rhizoma arisaematis 9, frankincense 3, myrrh 3, Radix Angelicae Sinensis 9, peach kernel 4.5, cortex acanthopanacis 9, Pu Gong
English 9, safflower 9, borneol 1, camphor 2, gaultherolin 1.5, eucalyptus oil 1, carbomer 10, part neutralize Sodium Polyacrylate 20, second two
Amine tetraacethyl disodium 0.1, PVP K30 20, gelatin 15, glycerine 100, ethyl hydroxy benzoate 3, Dihydroxyaluminium Aminoacetate 1, citric acid 1, ethyl alcohol 5,
Water 150.
4. relaxing tendons and activating collaterals pain-relieving Babu cream according to claim 3, it is characterised in that：The Sodium Polyacrylate is part
Neutralize Sodium Polyacrylate.
5. a kind of preparation method of relaxing tendons and activating collaterals pain-relieving Babu cream as described in any one of claim 1-4, including following step
Suddenly：
S1)：The water that 8-15 times of weight is separately added into ground bettle, peach kernel decocts, merge ground bettle, peach kernel decoction liquor, filter
It crosses, filtrate is condensed into the water that relative density is 1.25-1.27g/ml, and to carry thick paste spare；
S2)：By the rhizome of davallia, teasel root, Rhizoma Et Radix Notopterygii, Radix Angelicae Sinensis, rhizoma arisaematis, safflower, dandelion, frankincense, myrrh and cortex acanthopanacis, this ten taste is former
Material medicine co-grinding obtains mixing coarse powder, 8-15 times of weight is added into mixing coarse powder, the ethyl alcohol of a concentration of 85-95% is oozed
It filters, collects liquid of filtering, recycle ethyl alcohol and be simultaneously concentrated into the alcohol extracting thick paste that relative density is 1.05-1.15g/ml, by alcohol extracting thick paste, ice
Water made from piece, camphor, gaultherolin, eucalyptus oil and step S1 proposes thick paste mixing and stirs evenly, and obtains drug extract；
S3)：Carbomer is mixed with Sodium Polyacrylate, glycerine stirring is added, adding water makes mixture be swollen, and obtains matrix I；
S4)：Disodium ethylene diamine tetraacetate is weighed, is dissolved in water, is added after PVP K30 and gelatin are mixed, at 50-80 DEG C
Under the conditions of dissolve by heating, obtain matrix II, matrix I made from matrix II and step S3 mixed, is stirred under conditions of 50-80 DEG C
0.5-2h obtains matrix III；
S5)：Water intaking is appropriate, respectively adding citric acid and Dihydroxyaluminium Aminoacetate, 10-30min is stirred, then by the dissolving of citric acid and Dihydroxyaluminium Aminoacetate
Liquid is all added to mixing in matrix III, obtains matrix IV；
S6)：Ethyl hydroxy benzoate is weighed, is dissolved with ethanol in proper amount, matrix IV is then added and stirs 10-30min, then is made with step S2
Drug extract press 30-50:1 mass ratio mixing, stir 0.5-1.5h, be coated with while hot it is compound, relative humidity 20-40%,
Up to product after temperature is dry under conditions of being 20-40 DEG C.
6. the preparation method of relaxing tendons and activating collaterals pain-relieving Babu cream according to claim 5, it is characterised in that：In the step S4
Heating for dissolving temperature be 60-70 DEG C, matrix I and matrix II mix after be to stir 0.5-1h under conditions of 60-70 DEG C.
7. the preparation method of relaxing tendons and activating collaterals pain-relieving Babu cream according to claim 6, it is characterised in that：In the step S5
Citric acid, Dihydroxyaluminium Aminoacetate the stirring and dissolving time be 10-20min.
8. the preparation method of relaxing tendons and activating collaterals pain-relieving Babu cream according to claim 7, it is characterised in that：In the step S6
Mixing time be 0.5-1h.
9. the preparation method of relaxing tendons and activating collaterals pain-relieving Babu cream according to claim 8, it is characterised in that：The step S2 and
Concentration of alcohol used in S6 is 90%.
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| CN201510119371.6A CN104644933B (en) | 2015-03-18 | Relaxing tendons and activating collaterals pain-relieving Babu cream and preparation method thereof |
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| CN101700331A (en) * | 2009-11-27 | 2010-05-05 | 安徽安科生物工程（集团）股份有限公司 | Bone joiner spray |
| CN101780169A (en) * | 2010-03-10 | 2010-07-21 | 广州白云山制药股份有限公司白云山何济公制药厂 | Traumatic injury analgesic cataplasm preparation and preparation method thereof |
| CN103751734A (en) * | 2013-12-04 | 2014-04-30 | 安徽安科余良卿药业有限公司 | Blood circulation invigorating and pain relieving adhesive plaster and preparation method thereof |
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| CN101700331A (en) * | 2009-11-27 | 2010-05-05 | 安徽安科生物工程（集团）股份有限公司 | Bone joiner spray |
| CN101780169A (en) * | 2010-03-10 | 2010-07-21 | 广州白云山制药股份有限公司白云山何济公制药厂 | Traumatic injury analgesic cataplasm preparation and preparation method thereof |
| CN103751734A (en) * | 2013-12-04 | 2014-04-30 | 安徽安科余良卿药业有限公司 | Blood circulation invigorating and pain relieving adhesive plaster and preparation method thereof |
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