CN104667170A - Traditional Chinese medicine suppository for treating dysmenorrhea and preparation method of traditional Chinese medicine suppository - Google Patents

Traditional Chinese medicine suppository for treating dysmenorrhea and preparation method of traditional Chinese medicine suppository Download PDF

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CN104667170A
CN104667170A CN201410699234.XA CN201410699234A CN104667170A CN 104667170 A CN104667170 A CN 104667170A CN 201410699234 A CN201410699234 A CN 201410699234A CN 104667170 A CN104667170 A CN 104667170A
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radix
chinese medicine
herba
dysmenorrhea
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不公告发明人
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Qingdao Shen Da New And High Technology Development Corp Ltd
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Qingdao Shen Da New And High Technology Development Corp Ltd
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Abstract

The invention provides a traditional Chinese medicine suppository for treating dysmenorrhea. The traditional Chinese medicine suppository comprises the following raw materials in parts by weight: selfheal, fructus evodiae, radix angelicae, cinnamon, mint, asarum, scutellaria baicalensis, ground beeltle, herba patriniae, herba epimedii, flowers carthami, angelica sinensis, herba leonuri, folium artemisiae argyi, rhizoma corydalis, caulis sargentodoxae, red peony root, lindera aggregate, campsis grandiflora, curcuma aromatic, ligusticum wallichii, caulis spatholobi, cortex moutan, salviae miltiorrhizae and achyranthes bidentata. The traditional Chinese medicine suppository has the efficacies of activating blood, removing stasis and eliminating dampness and heat, is applied to the diseases such as dysmenorrhea caused by qi stagnation and retention, excessive morbid leucorrhea and hypogastralgia, is suitable for treatment of common diseases such as chronic pelvic inflammation, chronic annexitis, ovarian cyst and dysmenorrhea, is significant in treatment, and has the advantages of fast dissolution and rapid drug release so as to reach the targets of rapidly relieving symptoms and treating.

Description

A kind of Chinese medicine suppository for the treatment of dysmenorrhea and preparation method thereof
Technical field
The present invention relates to medicine configuration product, the particularly a kind of Chinese medicine suppository for the treatment of dysmenorrhea and preparation method thereof containing deriving from plant composition.
Background technology
Women take blood as this, belongs to cloudy; Cold being a kind of YIN pathogen, People of the same tastes and habits like to be together, and women itself easily feels cold-evil and causes gynaecopathia.Doctor thinks stagnation of blood stasis, stays and gathers for pain, long-pendingly forms tumor.Stagnation of blood stasis is primary disease pathogenesis core.Cause the reason that blood stasis is formed, mainly contain cold coagulation and the stagnation of QI.Patients factors body yang deficiency, or daily life is careless, paddles menstrual period and drenches with rain, eating cold and uncooked food excessively, experience cold-evil, and cold-evil visitor appoints in punching and causes cold blood stasis.Woman is kind, and how strongly fragrant bosom is, often cause irritability stasis, disorder of QI movement, and gas and blood maintains mutually, disorder of QI must and blood system, formation qi depression to blood stasis.In addition puerperal in menstrual period intemperate sexual intercourse, or delivery and feed infant is too much, and artificial abortion, the punching of cesarean equivalent damage are appointed and uterus, and healthy energy is impaired, and evil poison invasion is fought with blood and tie, finally causes stagnation of blood stasis, stays poly-not all right, blood stasis vapour lock, gradually long-pending addiction, formation primary disease.Due to stagnation of blood stasis, stagnation of QI and blood may bring about pain, with the passing of time blood stasis, long-pending forms addiction, stasis blocking vessels of the uterus, and two essences can not be harmonious, therefore clinical manifestation is dysmenorrhea, addiction abdominal mass, infertile etc.
The generation of doctor trained in Western medicine by suppressing the activity of prostaglandin enzyme to reduce prostaglandin, prevented strong uterine contraction and spasm, thus alleviate or eliminate pain, the effective percentage of such medicine can reach 80%.Namely menstrual onset starts to take medicine as good, serve on 2-3 day.The medicine being used for the treatment of dysmenorrhea that Food and Drug Administration (FD A) ratifies has ibuprofen, ketoprofen, meclofenamic acid, diclofenac, mefenamic acid Cai Pusheng, ibuprofen (ibup rofen) 200 ~ 400mg, every day 3 ~ 4 times, or ketoprofen 200mg, every day 3 times.All there is good curative effect.
Motherland's medical science is thought, women is on the occasion of menstrual period or before and after row, occur that periodically lower abdomen pain or pain draw the waist bones of the body, and even the severe pain person of fainting, is called dysmenorrhea, has title " abdominal pain during menstruation ".Dysmenorrhea sees the earliest " golden plaque outline # the miscellaneous internal diseases in woman ".All there is periodically lower abdomen pain women on the occasion of menstrual period or front and back of passing through in ancient Chinese medicine doctor, or pain draws waist sacrum, and very then severe pain is fainted, and is called dysmenorrhea.Ancient Chinese medicine is without the record of " endometriosis " and " adenomyosis ".Show as that enclosed mass in abdomen is tangible to be levied, abdominal pain during menstruation, the symptoms such as menoxenia, with the category belonging to the traditional Chinese medical science " addiction abdominal mass ", " dysmenorrhea ", " loss of fecundity " and " menoxenia ".Think that its main pathogenesis is for " most report thinks that dysmenorrhea is common has qi depression to blood stasis, cold blood stasis, dampness and heat stasis, deficiency of both QI and blood regulating liver-QI to suffer from a deficiency of the kidney damage five pattern of syndrome for stagnation of QI and blood may bring about pain, ' not Rong Ze pain ".
The traditional Chinese medical science thinks that dysmenorrhea is the disease of long-term, an easily recurrence, and menstrual period or puerperal experience cold-evil, or the cold and cool raw food of surfeit, and prolonged illness enters the reasons such as bloodization is tired can cause dysmenorrhea.Women take blood as this, belongs to cloudy; Cold being a kind of YIN pathogen, People of the same tastes and habits like to be together, and women itself easily feels cold-evil and causes gynaecopathia.And " cold being a kind of YIN pathogen, its gas spasm " YANG QI being easily injured by cold, fight mutually with cloudy blood, thus affect QI-blood circulation; Women or experience cold-evil, or eating cold and uncooked food excessively then blood be cold coagulation, run smooth, " stagnation of QI and blood may bring about pain "; Or body YANG QI deficiency, cold from interior life, punching appoints uterus to lose in warm, affects QI-blood circulation.No matter be exogenous cold, endogenous cold, or excess-cold, deficiency and coldness, be usually mutual existence, interactional.Namely "Fu Qingzhu works on obstetric" has " cold-damp be pathogen also, the arteries and veins that married woman has punching to appoint occupy the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, through water by two through and go out, and cold-damp full two through and civil strike, two disaccord and make pain " discussion.
Primary disease " stagnation of QI and blood may bring about pain ", " not Rong Ze pain " are the bases that dysmenorrhea occurs: think that dysmenorrhea causes qi and blood disorder due to incoordination of seven emotions etc., the stagnation of QI is not all right, blood stasis uterus, stagnation of QI and blood may bring about pain; Taste element is weak, changes source not enough, or serious disease prolonged illness and after passing through, and gas is weak agitates deficiency, and blood deficiency vessels of the uterus loses in moistening foster, not Rong Ze pain; Air-cooled cold-damp visitor appoints in punching, in born of the same parents, or element reports yang deficiency, and contain in YIN pathogen, hyperamization is stagnant not all right, stays poly-ly to have a pain; And the heresy that sense in puerperal in menstrual period is damp and hot, or there is retention of damp-heat in the interior place, delays and appoints in punching, pent up in born of the same parents, fight mutually with menses, therefore send out as dysmenorrhea.
Ancient Chinese medicine is without the record of " endometriosis " and " adenomyosis ".Modern medicine thinks that the two all has any different in the cause of disease, epidemiologic feature and clinical manifestation in recent years, and both are same disease in fact in Chinese medicine, all to show as in abdomen that enclosed mass is tangible to be levied, abdominal pain during menstruation, the symptoms such as menoxenia, with the category belonging to the traditional Chinese medical science " abdominal mass abdominal mass ", " dysmenorrhea ", " loss of fecundity " and " menoxenia ".The Basic disease cause pathogenesis of its " blood stasis ", many doctors reach common understanding.Because all kinds of reason causes " blood circulating out of vessels ", when OK, when rushing down, stagnating in body and becoming blood stasis.Its sick position is at the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and uterus, collaterals of the uterus are disease.Uterus silt resistance, vessels of the uterus, collaterals of the uterus are obstructed, stagnation of QI and blood may bring about pain; Stagnation of blood stasis in CHONG and REN meridians causes infertile or menoxenia; With the passing of time the stasis of blood stagnant, gathers and form abdominal mass abdominal mass; Stagnation of QI and blood, becomes raw clinical many diseases.
Determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs is the core of the traditional Chinese medical science, dysmenorrhea combine in Coryza Treated by Syndrome Differentiation more dysmenorrhea occur time and accompanied symptoms distinguish cold and heat and asthenia and sthenia.If dragging pain, angor, twinge, tenderness are real; Dull pain, pendant pain, desire for being robbed and pressed are empty; Causalgia obtains hot anti-play and belongs to heat; Cold type of pain obtains hot alleviating and belongs to cold; Swollen be far more than pain, vow gas then relax, belong to the stagnation of QI; Pain is far more than swollen, and discharge through promoting the circulation of blood block, stomachache alleviates, and belongs to the stasis of blood; Premenstrual, menstrual period, pain was real, through after pain be void.Most doctor thinks that dysmenorrhea is divided into qi depression to blood stasis, cold blood stasis, dampness and heat stasis, deficiency of both QI and blood regulating liver-QI to suffer from a deficiency of the kidney damage five pattern of syndrome.
In a word, the generation of dysmenorrhea often hindered by feelings will, and daily life is careless, or six climate exopathogens cause harm, or congenital examining composes the factors such as not enough, causes that punching is appointed, uterus QI-blood circulation is smooth, because of obstructed and pain; Or cause punching and appoint a uterus to lose in moistening foster, because of not flourish and pain, and with pass through before and after rush times.The change of uterus QI and blood is closely related, and sick position is in uterus, and punching is appointed, and with stagnation of QI and blood may bring about pain, Rong Ze pain, is not main pathogenesis.
Dysmenorrhea is one of modal disease of gynecological, and its incidence rate report differs, and account for 42% ~ 90%, wherein severe pain is through accounting for 18%, nausea and vomiting can be accompanied, dripping cold sweat, deadly cold hand and foot time serious, very then faint, affect life and work more, unfavorable to the physical and mental health of women; But the treatment to dysmenorrhea, there is no desirable Therapeutic Method, western medical treatment, mainly to reduce prostaglandin in menstrual blood and symptomatic treatment, by using prostaglandin enzyme inhibitor, reduces prostaglandin (Prostaglandin, PG) generation, prevented strong or spastic uterine contraction, thus alleviate or eliminate pain, but its curative effect can not be lasting, thoroughly can not cure dysmenorrhea, and there is obvious drug side effect problem.The traditional Chinese medical science is controlled by integral syndrome differentiation opinion and is started with, and treatment dysmenorrhea demonstrates obvious advantage, has broad prospects.
Summary of the invention
Technical problem to be solved by this invention is, dysmenorrhea is a disease that is long-term, easily recurrent exerbation, can accompany nausea and vomiting, dripping cold sweat, deadly cold hand and foot, very then faint, affect life and work more time serious, totally unfavorable to the physical and mental health of women.Western medicine used premenstruum the effect prevented irritation, and using menstrual period has spasmolytic, analgesic activity, is characterized in that administration is easy, instant effect.But because its symptom mainly for its pain is eased pain, to simultaneous phenomenon improve not good, thoroughly can not cure dysmenorrhea, and because of side effect larger, can cause nausea, vomit, the gastrointestinal upset such as diarrhoea, also can cause stomatitis, dizziness, tinnitus, blurred vision, the untoward reaction such as erythra, extract oral, because abnormal smells from the patient is poor, take inconvenience, neither be popular.Suppository infiltrates pelvic cavity by medicinal liquid, makes the medicinal liquid that Intrapelvic uterus adnexa absorption strength is high, and plays therapeutical effect.Better to endometriosis, adenomyosis effect especially.Avoid oral liquid medicine to gastrointestinal irritant reaction.Medicine can absorb 50%-70% in uterus, and is not directly entered 3 Venous systems of pelvic cavity viscera by liver, makes dysmenorrhea rapid rehabilitation under medicine effective concentration effect.
For solving above-mentioned technical barrier, the invention provides a kind of Chinese medicine suppository for the treatment of dysmenorrhea, Chinese medicine suppository described in it comprises the crude drug of following parts by weight: Spica Prunellae 10 ~ 20 parts, Fructus Evodiae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts.
The Chinese medicine suppository of described treatment dysmenorrhea, the crude drug of following parts by weight can be comprised: Spica Prunellae 10 ~ 15 parts in Chinese medicine suppository described in it, Fructus Evodiae 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Herba Asari 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts.
The Chinese medicine suppository of described treatment dysmenorrhea, the crude drug of following parts by weight can also be comprised: Spica Prunellae 10 ~ 20 parts in Chinese medicine suppository described in it, Fructus Evodiae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Caulis Sargentodoxae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, the Radix Linderae 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine suppository of dysmenorrhea, and the preparation process in Chinese medicine suppository described in it comprises:
A, get the Radix Linderae, Cortex Cinnamomi, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari and the Herba Menthae way of distillation and be vaporized into crystalline particle;
B, again all the other crude drug are put into soak with ethanol, heat is extracted 2 times, is component 1;
C, then by the medicinal residues extracting in water 2 times that above-mentioned steps is extracted, be component 2;
D, finally by also 2-in-1 to component 1 and component; Add the crystalline particle after vaporization to stir, put into substrate Mixer pot and set type, ultraviolet is killed virus.
In described step a, the Radix Linderae, Cortex Cinnamomi, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari and Herba Menthae can be cut into fine grained, then with steaming process distillation, be vaporized into crystalline particle, stand-by after pulverizing.
In described step b, surplus stock medicine can be added in the ethanol accounting for its quality 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use is component 1.
In described step c, the medicinal residues of crude drug said extracted can crossed add water, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, obtain component 2.
In described steps d, above-mentioned two kinds of components can be merged, when concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, reclaim ethanol, add the crystalline particle after vaporization to stir, choose substrate 50 DEG C ~ 60 DEG C heating and melting, described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the medicine mastic that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.
For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method for the treatment of the Chinese medicine suppository of dysmenorrhea, and the preparation process of described Chinese medicine suppository also can be:
A, get the Radix Linderae, Cortex Cinnamomi, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari and Herba Menthae distillation be vaporized into crystalline particle;
B, get all the other crude drug and put into water and soak, heat is extracted 2 times, becomes extractum;
C, the crystalline particle of vaporization is pulverized after add in the extractum that above-mentioned steps obtains, put into substrate Mixer pot and set type, after ultraviolet sterilization, fill becomes suppository.
In described step b, surplus stock roguing can be got, dry, be ground into granule, soak 1 hour; Soaked crude drug is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, and get twice decocting liquid mixing, filtration, inserts the filtrate of filtration in economic benefits and social benefits vacuum concentrator, and when being concentrated into 80 DEG C, density is the concentrated solution of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator stand-by again.
General substrate used can be: semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, the proportioning of medicine fine powder and substrate is 1: 2 ~ 1: 4, be preferably 1: 3, or adopt poloxamer poloxamer as substrate, it has been widely used as the hydrophilic matrix of suppository, have the following advantages: softer than the dissolubility of other substrate, quick, drug loading is also higher.
The detailed directions of described suppository is as follows: by drug suppository removing cabinet of the present invention, take out stype, pull-out afterbody cotton thread, stype is included in vagina deep, cotton thread is stayed external, and 1 every night, morning next day plays pull-out tampon, and continuous use 7 days is a course for the treatment of.
The present invention adopts stype and tampon integrated technique, compensate for the deficiency of ordinary suppository, and ordinary suppository effectively can not be delivered to the depths of vagina.Due to the self purification of vagina, when there being foreign body to exist, can increase liquid secretion, got rid of by medicine external at short notice, both reduced curative effect, and extended the course for the treatment of again, increase expense pollutes underwear again.And the present invention overcomes this technical barrier, the suppository made can give full play to curative effect of medication, has safety good, the advantage that feasibility is good, and focus of going directly, reaches the object that gets rid of illness.
The advantages such as compared with prior art, this technology has convenient drug administration, and medicament is easy to manufacture, with low cost.The present invention has effect of blood circulation promoting and blood stasis dispelling, eliminating damp-heat, and for the pelvic inflammatory disease that the stagnation of QI is pented up, the diseases such as disease sees profuse leukorrhea, hypogastralgia, are applicable to the treatment of the commonly encountered diseases such as chronic pelvic inflammatory disease, chronic adnexitis, ovarian cyst, vaginitis, Be very effective simultaneously.This medical instrument has and dissolves fast, release advantage rapidly, reaches the object of rapid relief of symptoms and treatment.
Detailed description of the invention
Dysmenorrhea is the commonly encountered diseases of women, point former sore warp, often without pelvic inflammation, secondary dysmenorrhoea often with endometriosis, adenomyosis and pelvic inflammation.About dysmenorrhea, motherland's medical science has the record such as " menalgia ", " hanging pain over the perineum ", " through the lower cattle diaphragm of row ".All there is periodically lower abdomen pain women on the occasion of menstrual period or front and back of passing through in ancient Chinese medicine doctor, or pain draws waist sacrum, and very then severe pain is fainted, and is called dysmenorrhea.
Dysmenorrhea one sees the earliest " Medical Treasures of the Golden Chamber the miscellaneous internal diseases in woman arteries and veins disease is also controlled " " leukorrhagia, menstrual disorders, lower abdominal pain and fullness.Through goodbye in January." " General Treatise on the Cause and Symptoms of Diseases " cloud: " married woman's menstrual abdominalgia person, by impairment caused by overstrain vim and vigour, so that body is empty, by air-cooled gas visitor in collaterals of the uterus, fights with mutually with vim and vigour, therefore order pain is also ", and first vertical " menstrual abdominalgia time " they are research and treatment dysmenorrhea based theoretical.
About the etiology and pathogenesis of dysmenorrhea, ancients describe a lot of.Roughly there are three kinds of views: one, cause a disease because of the body void air-cooled heresy of impression.As front " General Treatise on the Cause and Symptoms of Diseases " namely proposes this viewpoint.In addition " Complete Effective Prescriptions for Women's regulating menstruation Men Yueshui go no go trusted subordinate twinge side opinion ": " Mr. and Mrs' man month menalgia person, by impairment caused by overstrain QI and blood, causes and make body empty; Air-cooled gas visitor, in collaterals of the uterus, damages the arteries and veins of appointing in punching, the warp of the hands sun, few the moon.Chong channel, conception vessel all arise from uterus, for sea of channels also.Therefore when water will go the moon, vim and vigour are moved in air-cooled, air-cooledly to hit mutually with QI and blood.Therefore order pain." " Chao Shi cause of disease " also say: " woman enter menstrual abdominalgia person, caused by the sub-collaterals of the uterus of air-cooled gas visitor ".
About the etiology and pathogenesis of dysmenorrhea, it is relevant with physiological environment special before and after ferritic and menstrual period, menstrual period that modern Chinese medicine thinks that it occurs.Between non-menstrual period, punching appoints QI and blood gentle, and paathogenic factor can not cause that punching is appointed, rich the stasis of blood is stagnant or not enough for born of the same parents, therefore pain does not occur, and before and after menstrual period or menstrual period, the sea of blood rushes down excessive by being completely full of, uterus QI and blood by arrogant blood prosperous to through after temporarily empty, QI and blood change is anxious to gather, paathogenic factor is taken the opportunity and does, make QI-blood circulation not smooth, born of the same parents are rich, and menses circulation is obstructed, so that stagnation of QI and blood may bring about pain; Or cause punching appoint a uterus lose in moisten support not flourish and pain.Take a broad view of many doctor's documents, all unanimously think that the basic pathogenesis of dysmenorrhea is " stagnation of QI and blood may bring about pain ", " not Rong Ze pain ".
Recent domestic scholar starts to grind from EPDML angle to get to the bottom of sb.'s illness, to find the measure of effective treatment and prevention dysmenorrhea.Epidemiology thinks that primary dysmenorrhea is more common in 15-25 year unmarried female, is one of common symptom of adolescence, and has certain hereditary basis; Age of menarche in advance, unhealthy emotion, Bad Eating Habit, the sleep such as depressed and anxiety less, smoking, drink, hyperkinesia is its risk factor; Full-term pregnancy childbirth, Sufficient Sleeping and modest movement are then protection factor.Gynecopathy is apt to occur in 25-45 year women at fertile age, and it has certain hereditary basis; Menarche time advance, cycle time, menostaxis and menorrhagia, dysmenorrhea, motion in menstrual period, heavy burden, sexual intercourse, artificial abortion, places the operations on pelvis such as IUD, dioxin, autoimmune disease history, stature is weedy, too much takes in caffeine, pungent diet, operating pressure is large, and schooling is high, unhealthy emotion, A blood group, endocrine regulation history of disease etc. is the risk factor of endometriosis; Full-term pregnancy, oral contraceptive, smoking etc. are protection factor.Adenomyosis is apt to occur in the multipara of more than 40 years old, and high estrogen level, fecund, repeatedly artificial abortion's dilatation and curettage of uterine history, reproductive tract block for its risk factor.
Motherland's medical science is to the understanding of dysmenorrhea, and mainly QI-blood circulation is not smooth, stagnation of QI and blood may bring about pain, qi being the governor of blood, blood circulation depending on qi flow, stagnation of QI-blood can be not smooth because of emotion, depression of liver-QI, functional activity of QI being not smooth, blood can not lead to air-flow, in prescription, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Semen Persicae, Flos Carthami, Rhizoma Sparganii, Cortex Moutan nourish blood, and blood circulation promoting and blood stasis dispelling has dispelling cold by warming the meridian, regulate the flow of vital energy the merit of removing blood stasis, Rhizoma Corydalis, Caulis Sargentodoxae, Herba Patriniae, Radix Achyranthis Bidentatae, have promoting blood circulation to remove blood stasis inducing menstruation to relieve menalgia, conducting blood to flow downwards, Rhizoma Corydalis has the functions such as eliminating carbuncle eliminating stagnation.Middle stype medicinal liquid input rectum, by the osmosis of intestinal mucosa, medicinal liquid infiltrates pelvic cavity, makes the medicinal liquid that Intrapelvic uterus adnexa absorption strength is high, and plays therapeutical effect.Better to endometriosis, adenomyosis effect especially.Avoid oral liquid medicine to gastrointestinal irritant reaction.Medicine at rectal absorption 50%-70%, and can directly not enter 3 Venous systems of pelvic cavity viscera by liver, make dysmenorrhea rapid rehabilitation under medicine effective concentration effect.
The pathogeny of primary dysmenorrhea is comparatively complicated, though modern medicine has been deep into molecule, cellular level to the research of primary disease, illustrates not yet completely at present.Endometrium is the significant points of synthesis of prostaglandins, and many evidences show, endometrium synthesis and release prostaglandin increase, be primary dysmenorrhea focus on reason; And PGF in most of primary dysmenorrhea women peripheral blood 2a, PGF 2ratio significantly raises.The traditional Chinese medical science is thought, dysmenorrhea morbidity has void to have reality, the void of the QI and blood Liver and kidney of the many duties of empty person, the stagnation of QI of the many duties of real person and cold, heat, damp invasion and attack.For cold and stagnate, qi stagnation and blood stasis type primary dysmenorrhea common in clinical, the author's employing take dispelling cold by warming the meridian, promoting flow of QI and blood as the suppository in treatment of the present invention of the main principles of formulating prescriptions, Herba Asari in side, Cortex Cinnamomi, Fructus Evodiae are the product of the large heat of great Xin, function cold expelling analgesic therapy: the blood stasis-eliminating and stagnation-dissipatings such as Radix Angelicae Sinensis, the Radix Paeoniae Alba, Flos Carthami, Olibanum, Myrrha, Sanguis Draxonis; Heavy dose of application drug for invigorating blood circulation and eliminating stasis, through clinical observation, can't making through amount showed increased, even if at ordinary times through measuring too much patient, help with Herba Leonuri, getting the pharmacological action that it shrinks uterus, excited uterus, can make to reduce through amount; Rhizoma Corydalis promoting the circulation of QI to relieve pain, effect is excellent compared with Rhizoma Cyperi, the Radix Linderae.Scorpio spasmolytic, for controlling dysmenorrhea, effect is significantly same.
Flos Carthami, another name: red indigo plant flower, thorn Flos Carthami, Latin literary fame: Carthamus tinctorius L. Compositae, Flos Carthami platymiscium, dry tubular flower, is about 1.5 centimetres, orange red, floral tube is carefully narrow, and tip 5 splits, sliver is narrow linear, long 5 ~ 8 millimeters, 5 pieces, stamen, flower pesticide is yellow, be unified into pipe, exceed outside sliver, its central authorities have stigma to expose.The special fragrance of tool, mildly bitter flavor.To spend, length of a film, color are scarlet, the soft person of matter is good.The ground such as main product Henan, Hunan, Zhejiang, Sichuan.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, swells and ache for amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection.Have blood circulation promoting and blood stasis dispelling, wet dissipation goes the effect swollen, but anemia of pregnant woman will be avoided to use, otherwise can cause miscarriage.Flos Carthami can be used for foot bath, contributes to accelerating foot's blood circulation.
Caulis Sargentodoxae: Caulis Sargentodoxae is the rattan of plants of Lardizabalaceae Caulis Sargentodoxae.Bitter in the mouth, property is put down.Return large intestine, Liver Channel.Tool removing toxicity for eliminating carbuncles, promoting blood circulation and stopping pain, expelling wind and removing dampness, disinsection efficiency.Cure mainly acute appendicitis, dysentery, mastalgia, dysmenorrhea, amenorrhea, traumatic injury, rheumatic arthralgia, abdominal pain due to worm stagnation.Rhizome is pharmaceutically acceptable, has dredge the meridian passage, eliminating stasis to stop pain, effect such as promoting the circulation of blood, parasite killing of regulating the flow of vital energy, cure mainly rheumatalgia, joint acid that Changes in weather causes be swollen, traumatic injury, dysmenorrhea, amenorrhea, ascarid.Also can make veterinary medicament, to the oxen and horses, food supply retail shop's Hirudo associated diseases is effective in cure by mistake.Root can make dyestuff.
Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri, containing the material such as leonurine, Fumaric acid, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.
Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea.External is gynecological's good medicine of activating blood circulation to dissipate blood stasis.
Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
The current domestic Dragon Blood of Sanguis Draxonis mostly is Liliaceae Dracaena cochinchinensis or dracaena cambodiana Pierre resin.Foreign resina draconis is comparatively rare.Yunnan Folium Dracaenae cambodianae is damaged rear flowed out myron can make Sanguis Draxonis through processing.Effect takes promoting blood circulation to remove blood stasis orally, analgesic therapy, external hemostasia and promoting granulation, sore.Cure mainly 1. congestion amenorrhea, dysmenorrhea, postpartum stagnation.2. lump in the abdomen mass in the abdomen, breast ventral spine pain.3. traumatic injury, congestion swells and ache.4. traumatic hemorrhage, ulcer being unable to heal.
A kind of Chinese medicine material of Flos Campsis, has promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, and acrid in the mouth acid, cold nature returns liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. " Amplification on Materia Medica addendum ": Flos Campsis, control the key medicine of pain in blood also, and nourishing YIN victory very, is stamped and keeps and walk alone, in married woman side multiplex what." Nanning City's medicine will ": the merit having eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting, controls red Hakuri.
Rhizoma Cyperi is regulated the flow of vital energy resolving depression; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Rhizoma Corydalis (Corydalis yanhusuo W.T.Wang ex Z.Y.Su et C.Y.Wu), Papaveraceae, Corydalis perennial herb, another name: Rhizoma Corydalis, corydalis tuber, rhizoma corydalis, Rhizoma Corydalis.Chinese tradition medical material.Mainly originate in Zhejiang and Jiangsu.Its tuber (Rhizoma Corydalis Decumbentis), containing the multiple alkaloid such as corydaline, protopine, through making powder or fluid-acet-extract etc., cures mainly all pains of trusted subordinate's waist knee joint; Menoxenia; Lump in the abdomen; Metrorrhagia; Puerperal blood faints; Lochiorrhea; Traumatic injury.There are analgesia, calmness, syngignoscism.
Rhizoma Chuanxiong enters liver, spleen, three burnt three warps.Function cures mainly activating QI to alleviate the depression, and method wind-dryness is wet, promoting blood circulation and stopping pain.Controlling air-cooled headache revolves dizzy, and hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." detailed outline " carries: " dampness, antidiarrheal dysentery, activating QI to alleviate the depression." ligustrazine removes vascular smooth muscle (aortic article) spasm (epinephrine, potassium chloride cause).Can also coronary vasodilator be expanded, increase coronary flow.The myocardial ischemia-anoxemia that antagonism pituitrin causes.Alleviate the myocardial infarction lesion degree that ligation arteria coronaria causes.
Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Cortex Moutan and Cortex Moutan, Chinese medicine name.For the dry root bark of ranunculaceae peony.Originate in the ground such as Anhui, Sichuan, Henan, Shandong.There is effect of clearing away heat and cooling blood, activating blood circulation to dissipate blood stasis, reducing the asthenic fever.Clearing away heat and cooling blood; Promoting blood circulation to remove blood stasis.The epidemic febrile disease pathogenic heat attacking blood system in febrile diseases; Send out speckle; Tell nosebleed; The calentura later stage, hot Fu Yin divided heating; Deficiency of YIN osteopyrexia and fever; Amenorrhea due to stagnation of blood; Dysmenorrhea; Carbuncle sore tumefacting virus; Fall and flutter the pain of injury; Beriberoid pyretic arthralgia.Control blood deficiency overstrain dysphoria with feverish sensation in the chest palms and soles limbs pain head dusk center of gravity alarmed and panicky cheek red dryness of the mouth and throat heating night sweat to subtract food drowsiness and heat in blood and to fight mutually unsmooth menorrhea umbilicus abdominal distention and pain fever and chills similar to malaria; Control again unmarried girl's blood weak deficiency of YIN Rong Wei discord phlegmatic cough hectic fever human body weakness and emaciation." herbal classic ": " main cold and heat, apoplexy Chi Zong, convulsion, infantile convulsion pathogen, except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treat carbuncle skin ulcer."
Herba Epimedii is Chinese conventional Chinese medicine, has very high medical value, perennial herb, and YIN nourishing is taken a tonic or nourishing food to build up one's health, and tonifying YANG is kept fit.Bitter and puckery flavor, suitable insomniac uses.Herb hyoscine.Cure mainly impotence and premature ejaculation, pain in the low back and legs, numb limbs and tense tendons, hemiplegia, neurasthenia, forgetful, tinnitus, dizzy disease such as grade.Excessive sheep flower bud is Chinese conventional Chinese medicine.
The acid of Radix Achyranthis Bidentatae mildly bitter flavor, cold in nature, nontoxic." Yunnan Chinese herbal medicine ": " sweet micro-acid, cool." enter the heart, liver, large intestine three warp.Effect is classified, blood circulation and stasis-eliminating medicine.Effect promoting blood circulation to remove blood stasis, damp eliminating diuresis, heat-clearing and toxic substances removing.Control gonorrhea, hematuria, women's amenorrhea, lump in the abdomen, rheumatic arthritis, beriberi, edema, dysentery, malaria, diphtheria, carbuncle, traumatic injury.
Herba Patriniae nature and flavor hardship is flat, has effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain can be cured.Enter stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the stagnant caused breast abdomen pain of the excess-heat stasis of blood, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.
Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort Artemisia argyi Levl.et Vant..Most of China area is all produced.Be good with Hubei Qi Zhou (local of Li Shizhen (1518-1593 A.D.)) product person, claim " Artemisia argyi Levl. et Van. var. argyi cv. Qiai ", because it obtains rustic suitable, leaf is thick and floss is many, and as the material of moxibustion treatment, power is maximum.Pluck when summer, flower was not opened, removing impurity, dries or dries in the shade.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, there is warming the meridian for stopping bleeding, dispersing cold for relieving pain, effect of wet down parasite killing.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, nontoxic; Return spleen, liver, kidney channel; Fragrance temperature is loose, can rise to fall to have warming the meridian for stopping bleeding, dispersing cold for relieving pain, and effect of wet down parasite killing, cures mainly menoxenia, dysmenorrhea, infertility, frequent fetal movement, trusted subordinate's cold type of pain, spits blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia, gestation hemorrhage, chronic dysentery of having loose bowels, leukorrhagia, eczema, scabies, carbuncle, hemorrhoid.Moxibustion treatment all kinds of diseases and ailments.
The Radix Linderae has pharmacologically active comparatively widely, mainly as follows:
1, the excitation of volatile oil: time for oral administration, have excited corticocerebral effect, and have promotion to breathe, excited cardiac muscle, accelerates blood circulation, the effect of raising blood pressure and diaphoresis.Local topical makes local vascular dilation, and blood circulation accelerates, and relaxes muscle spasm pain.2, bacteriostasis: to staphylococcus aureus, α-hemolytic streptococcus, Bacillus typhi, Bacillus proteus, bacillus pyocyaneus, escherichia coli all have inhibitory action.3, on gastral impact: have the report Radix Linderae to have dual function to gastrointestinal smooth muscle, in addition, the Radix Linderae can increase the secretion of Digestive system.4, anastalsis: experiment in vitro proves, Radix Linderae dry powder can obviously shorten plasma in rabbit recalcification time, promotes blood clotting and good anastalsis.5, other effect: feed rat for a long time with the Radix Linderae, body weight can be made to increase, and have inhibitory action to murine sarcoma-180.Its Borneolum Syntheticum can diaphoresis, excitement, spasmolytic, anthelmintic etc.
Fructus Evodiae formal name used at school Tetradium ruticarpum, original name Euodia ruticarpa, another name Fructus Evodiae, tea is peppery, paint spicy, smelly spicy tree, Zuo Lichun deep and remote son, rice spicy etc.Fructus Evodiae comes from " herbal classic ": " main warming the middle warmer and descending qi, pain relieving, cough with dyspnea cold and heat, dehumidifying, arthralgia due to stagnation of blood, by ailment said due to cold or exposure, loosing the interspaces of skin and muscles." Compendium of Material Medica: " dissipating depression of QIization is stagnant, controls acid regurgitation, and cloudy sputum of fainting is had a headache, insidious stomachache, hernia dysentery, mouthpiece's aphtha." its bitter in the mouth hot in nature is pungent, has the merit of dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, is used for the treatment of that liver insufficiency of stomach is trembled with fear, the disease such as headache or gastralgia caused by cloudy turbid superinverse.
Cortex Cinnamomi complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.Control decline of the fire from the gate of life, cold extremities faint pulse, YANG-depletion is collapsed, and stomachache is had loose bowels, colic of cold type renal mass, chills and pain of the waist and kness, amenorrhea lump in the abdomen, carbuncle of yin nature, multiple abscess, and empty sun is more floating, heat in the upper and cold in the lower." herbal classic ": Your Majesty's gas cough with dyspnea, stagnation of QI sore throat tells suction, sharp joint, invigorating the spleen and replenishing QI." not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago, only saliva, cough ， Bi Weng: can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, without feared.
Radix Angelicae Dahuricae acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel; Fragrance rises loose.There is expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidify sensible, effect of detumescence and apocenosis.Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet Sheng chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, venom.
Herba Asari cures mainly: dispel the wind, cold expelling, and row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.Herba Asari can outer dispersing wind and cold, again can in dispel YIN-cold, pain relieving simultaneously, antitussive effect are better.Herba Asari is as medicinal plants, and Shi Zai Qin Han Shennong's Herbal, Shennong's Herbal is classified as top grade.Herba Asari root is thin, color sallow, leaf color are green, the peppery numb tongue of acrid in the mouth.Warm in nature, slightly poisonous.GUIXIN, lung, kidney channel.Dispel the wind, cold expelling, warming the lung, Hang Shui, the effect of having one's ideas straightened out.Control headche due to wind-cold, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.In addition, Herba Asari also has anti inflammatory immunity, local anesthesia, raising metabolism, antibacterial action, also can be used for the leukopenia of Chemotherapy of Tumor Patients and caused by radiation.
Herba Menthae is one of Chinese conventional Chinese medicine, and it is pungent cool property sweating antipyretic medicine, can control influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.For stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.These product double enter Liver Channel, can dispersing the stagnated live-QI to relieve the stagnation of QI, often coordinate the product of the depressed liver-energy dispersing and QI regulating regulating menstruations such as Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, treatment stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, menoxenia, as XIAOYAO POWDER.
Eupolyphaga Seu Steleophaga has effect of removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.Pharmacological evaluation, has the effect of dispersing swelling and dissipating binds.Cure mainly blood stasis etc. in traumatic injury, abdomen.Containing volatile oil and aminoacid.Volatile oil total amount about 22%, is mainly naphthalene, fatty aldehyde, aromatic aldehyde; Total amino acid content about 40%.Pharmacology: hematocrit, whole blood high shear viscosity, whole blood low shear viscosity, erythrocyte aggregation index, erythrocyte mechanical fragility can be made all to reduce, make erythrocyte sedimentation rate, erythrocyte sedimentation rate constant obviously raises.In addition effects such as also having blood fat reducing, anoxia enduring, ease pain, resist myocardial ischemia.Cold in nature, salty in the mouth; Slightly poisonous.Function cures mainly: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.
Spica Prunellae Spica Prunellae is cold in nature, sweet in the mouth, pungent, micro-hardship, there is the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, be applicable to lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc.Modern pharmacological research shows, Spica Prunellae has the effect reduced blood pressure, and energy blood vessel dilating, contained by it, rutin has antiinflammatory action, and can reduce vascular permeability, reduces fragility, reduces liver fat.Spica Prunellae also has the effect of resisting cancerous cell." herbal classic ": main cold and heat, scrofula, scrofula, head sore, broken disease, loose wart stagnation of QI, swelling of the feet arthralgia chiefly caused by damp pathogen.
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical practice of Radix Scutellariae is antibacterial not worse than Rhizoma Coptidis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by Radix Scutellariae extracting solution effect." Bencao Jingshu ": Radix Scutellariae, its property is respectful clearly, so evil removing: bitter in the mouth is so dampness; YIN-cold is so victory heat, therefore main all heat.All hot persons, pathogenic heat with all over heat also, jaundice, intestinal be out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestinal profit and water from by, source is clearly then flowed also clean.The blood person of closing, excess-heat is at blood system, and instant heating human blood room, it is obstructed to make us amenorrhea, and damp and hot solution, then Ying Qi clearly and voluntarily also.Malignant boil cellulitis erosion person, heat in blood then stays knot, and is that carbuncle stain is also rotten: acute scleritis person, also, removing heat from blood heat extraction, then spontaneous recovery also for fire of moxibustion blood trouble.Specific embodiment 1: the preparation of suppository of the present invention
Get raw material Radix Linderae 1500g, Cortex Cinnamomi 1500g, Sanguis Draxonis 1500g, Rhizoma Chuanxiong 1500g, Radix Angelicae Dahuricae 1500g, Herba Asari 1500g, Herba Menthae 1500g, be cut into granule, be vaporized into white crystals, pulverize stand-by.Again by Spica Prunellae 1500g, Radix Scutellariae 1500g, Eupolyphaga Seu Steleophaga 1500g, Herba Patriniae 1500g, Herba Epimedii 1500g, Flos Carthami 1500g, Radix Angelicae Sinensis 1500g, Herba Leonuri 1500g, Folium Artemisiae Argyi 1500g, Rhizoma Corydalis 1500g, Caulis Sargentodoxae 1500g, Radix Paeoniae Rubra 1500g, Flos Campsis 1500g, Radix Curcumae 1500g, Caulis Spatholobi 1500g, Cortex Moutan 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Achyranthis Bidentatae 1500g steeps in water, soak more than 2 hours, add respectively account for crude drug gross mass 8 times amount, 6 times amount water extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.The medicinal residues of crude drug said extracted crossed add ethanol, and add the ethanol warm macerating 2 times of 10 times amount of medicinal residues gross weight, 8 times amount respectively, the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merges 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.By also 2-in-1 to component 1 and component, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, inserted in economic benefits and social benefits vacuum concentrator by above-mentioned two kinds of extracting solution, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.60, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again and is condensed into extractum, the crystalline particle adding vaporization stirs, choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet is killed virus.Described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the medicine mastic that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.
Specific embodiment 2: the preparation of suppository of the present invention
Get raw material Radix Linderae 1300g, Cortex Cinnamomi 1200g, Sanguis Draxonis 1200g, Rhizoma Chuanxiong 1100g, Radix Angelicae Dahuricae 1200g, Herba Asari 1200g, Herba Menthae 1200g, be cut into granule, be vaporized into white crystals, pulverize stand-by.Get raw material Spica Prunellae 1100g, Radix Scutellariae 1200g, Eupolyphaga Seu Steleophaga 1200g, Herba Patriniae 1100g, Herba Epimedii 1200g, Flos Carthami 1200g, Radix Angelicae Sinensis 1200g, Herba Leonuri 1200g, Folium Artemisiae Argyi 1200g, Rhizoma Corydalis 1100g, Caulis Sargentodoxae 1200g, Radix Paeoniae Rubra 1200g, Flos Campsis 1200g, Radix Curcumae 1200g, Caulis Spatholobi 1100g, Cortex Moutan 1200g, Radix Salviae Miltiorrhizae 1200g again, Radix Achyranthis Bidentatae 1200g, get crude drug clean dry, in 70 DEG C of baking ovens, dry 1-3h, taking-up is placed in cooling in drying baker, pulverizes 80-100 mesh sieve with pulverizer.By for subsequent use for the fine powder sieved, unsifted coarse granule one bubbles in ethanol after 1-2 days, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-110 order filters, be the ultrafiltration post ultrafiltration of 6000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating be concentrated into paste, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2mg crude drug amount, is then dried to powder, add the fine powder sieved, and crystalline particle, stir, choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet is killed virus.Described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the medicine mastic that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.
Specific embodiment 3: the preparation of suppository of the present invention
Get raw material Radix Linderae 1300g, Cortex Cinnamomi 1200g, Sanguis Draxonis 1200g, Rhizoma Chuanxiong 1100g, Radix Angelicae Dahuricae 1200g, Herba Asari 1200g, Herba Menthae 1200g, be cut into granule, be vaporized into white crystals, pulverize stand-by; Get surplus stock Spica Prunellae 1100g, Radix Scutellariae 1200g, Eupolyphaga Seu Steleophaga 1200g, Herba Patriniae 1100g, Herba Epimedii 1200g, Flos Carthami 1200g, Radix Angelicae Sinensis 1200g, Herba Leonuri 1200g, Folium Artemisiae Argyi 1200g, Rhizoma Corydalis 1100g, Caulis Sargentodoxae 1200g, Radix Paeoniae Rubra 1200g, Flos Campsis 1200g, Radix Curcumae 1200g, Caulis Spatholobi 1100g, Cortex Moutan 1200g, Radix Salviae Miltiorrhizae 1200g again, Radix Achyranthis Bidentatae 1200g, steep in ethanol, soak more than 2 hours, add respectively account for crude drug gross mass 8 times amount, 6 times amount ethanol extraction 2 times, extraction time is 2 hours, 1 hour; Merge 2 extracting solution, extracting solution is centrifugal by tubular type, obtains centrifugal liquid, and centrifugal liquid is crossed D 101 macroporous resin and adsorbed, and first washes remove impurity with water, then carries out eluting with the ethanol of 70%, collects eluent, concentrating under reduced pressure, and one-tenth extractum, for component becomes 1.The medicinal residues of crude drug said extracted crossed add ethanol, add 10 times amount of medicinal residues gross weight respectively, the water temperature of 8 times amount soaks 2 times, and the warm macerating time is 2 hours, 1.5 hours, and temperature is 85 DEG C, merge 2 warm macerating liquid; Warm macerating liquid is evaporated to 1.25 extractum when density is 60 DEG C, and extractum is added the extraction into ethyl acetate secondary of its 4 times amount, extract has reclaimed ethyl acetate, becomes extractum, obtains component 2.Extract extractum by above-mentioned 4 times to merge, when concentrating under reduced pressure relative density is 80 DEG C 1.28 pasty state, reclaim ethanol, by gained pasty state, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.50, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.2mg crude drug amount, adds the crystalline powder of vaporization, stir.Choose substrate 50 DEG C ~ 60 DEG C heating and melting, add ointment cooling and shaping obtained above and make class warhead shape suppository, ultraviolet is killed virus.Described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the medicine mastic that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.
General substrate used can be: semi-synthetic fatty acid glyceride, lanoline, Polyethylene Glycol, the proportioning of medicine fine powder and substrate is 1: 2 ~ 1: 4, be preferably 1: 3, or adopt poloxamer poloxamer as substrate, it has been widely used as the hydrophilic matrix of suppository, have the following advantages: softer than the dissolubility of other substrate, quick, drug loading is also higher.
The detailed directions of described suppository is as follows: by drug suppository removing cabinet of the present invention, take out stype, pull-out afterbody cotton thread, stype is included in vagina deep, cotton thread is stayed external, and 1 every night, morning next day plays pull-out tampon, and continuous use 7 days is a course for the treatment of.
Pharmacological toxicity is tested
One, antibacterial experiment
In body, antibacterial tests result shows, the animal of suppository of the present invention to escherichia coli and Bacillus proteus has significant protective effect, can subtract the development of the state of an illness, reduces the mortality rate of animal; Antimicrobial test result shows, the prostatitis antibacterial of urinary system bolt to urinary system infection has antibacterial and bactericidal action in various degree; The prostatitic experimental result that affects of experimental rat is shown, the present invention can anti-bacteria infect after the weightening finish of urinary system body of gland, slow down the development of the state of an illness, suppress the Pathological morphologic change of prostata tissue; Within after administration 2-5 hour, the urine volume of animal can be made obviously to increase; Obvious cooling effect in 5 hours after the rabbit body temperature rising administration that fresh yeast is caused; The animal auricular concha swelling that xylol causes and have obvious inhibitory action to granuloma induced by implantation of cotton pellets tissue, and suppress the increase of capillary permeability; Certain inhibitory action is had to the pain that chemical substance stimulating animal peritoneum or thermal stimulus animal body surface cause.
Result of the test shows: Chinese medicine suppository experiment safety of the present invention.This medicine is 1: 150 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 150, Candida albicans is 1: 300, it is 5 minutes to the time of killing during 1: 20 dilution factor, be 10 minutes when 1: 50, being 20 minutes when 1: 100, is 40 minutes when 1: 200, is 8 hours when 1: 400.
Two, animal acute toxicity test research:
When the present invention adopts rectal delivery, the maximum dosage-feeding on the one recording mice is 62.7g/kg (in medicated powder), be about 1567.5 times (people is in 60kg) intending clinical people's consumption, the maximum dosage-feeding 62.7g/kg (in medicated powder) on the one of rat, is about 1567.5 times that intend clinical people's consumption.The equal Continuous Observation of laboratory animal one week, its outward appearance sign, the mental status, diet, drinking-water, feces etc. are showed no obvious abnormalities.At the end of experiment, all healthy survival of animal, body weight increases.
Three, long-term toxicity test for animals research:
This test establishes suppository drug of the present invention high, in, low dose group and Matrix controls group, blank group, rectal delivery is adopted to give rat, dosage is respectively 3.2, 2.4 and 1.6g/kg (in medicated powder), be equivalent to intend 80 of clinical patient consumption [0.04g (medicated powder)/kg], 60 and 40 times, successive administration 2 months, in administration process, the body weight of each administration group and matrix group rat, dietary amount, outward appearance sign, behavioral activity, the mental status, hair color, feces character compares with blank group, no significant difference (P > 0.05), the weight of animals increasing value and Main Organ Coefficients and blank group comparing difference are not significantly (P > 0.05), hematology and the indivedual index of blood parameters check result administration group and blank group comparing difference are significantly (P < 0.05), but convalescent period terminates rear discrepant hematology and blood parameters has recovered normal all, other indexs and blank comparing difference are not significantly (P > 0.05), administration phase and convalescent period histological examination high dose group animal main organs compare with blank group and have no notable difference, have no slowness toxicity to occur.
Four, animal local excitation test:
The allergic reaction on guinea pigs of suppository of the present invention and Rat-rectum medication irritation test.
Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.
Five, vaginal mucomembranous irritant test result
1. test method:
After laboratory animal is quarantined 3 days, select 18 above-mentioned healthy rabbits, be divided into three groups at random, often organize each 6, be respectively: blank, excipient control, suppository group of the present invention (by application liquid 5 times of concentration).Be placed in excipient control group and the intravaginal of tested material treated animal with the sterilizing cotton sliver leaching of suitable size with sterile saline and tested material respectively, contact 6 hours with vaginal mucosa, after 24 hours, put to death animal.Taking-up topical vaginal tissue, observes pathological changes situation.
2, result of the test: vaginal mucomembranous irritant test result
Clinical trial:
Dysmenorrhea is the commonly encountered diseases of women, point former sore warp, often without pelvic inflammation, secondary dysmenorrhoea often with endometriosis, adenomyosis and pelvic inflammation.We are on the basis of differentiation of tcm, adopt herbal drug enema in treatment dysmenorrhea, evident in efficacy, and existing report is as follows; This research observes suppository of the present invention to primary dysmenorrhea patient Plasma Prostaglandin in menstrual period F (PGFz) and prostaglandin E (PGE.) impact of ratio inquires into the mechanism of action for the treatment of primary dysmenorrhea.
L physical data
60 routine patients all come from the patient of the author place hospital outpatient.The diagnostic criteria of equal reference " new Chinese medicine guideline of clinical investigations " is made a definite diagnosis.Be divided into treatment group and matched group at random.Treatment group 30 example, 22.5 years old mean age, 1 example that the state of an illness is slight, moderate 17 example.Severe 12 example; Matched group 30 example, 22.2 years old mean age, 2 examples that the state of an illness is slight, moderate 12 example, severe 16 example.2 groups through statistical procedures, no significant difference (P>0.05), tool comparability.
2 Therapeutic Method.
2.1 Therapeutic Method:
Treatment group, give suppository of the present invention, Fang Yong: Spica Prunellae, Fructus Evodiae, the Radix Angelicae Dahuricae, Cortex Cinnamomi, Herba Menthae, Herba Asari, Radix Scutellariae, Eupolyphaga Seu Steleophaga, Herba Patriniae, Herba Epimedii, Flos Carthami, Radix Angelicae Sinensis, Herba Leonuri, Folium Artemisiae Argyi, Rhizoma Corydalis, Caulis Sargentodoxae, Radix Paeoniae Rubra, the Radix Linderae, Flos Campsis, Radix Curcumae, Rhizoma Chuanxiong, Caulis Spatholobi, Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, each 15g makes suppository.Every piece containing crude drug 20g.Usage: each l piece, every day 3 times, rectally.Started in premenstrual 4 days to stop with to the 3rd day menstrual period.
Matched group, the peaceful suppository of dysmenorrhea (being made up of Radix Aconiti Preparata, Herba Asari, Fructus Evodiae etc.), is provided by Qingdao City's Hospital Pharmacy of TCM.Every piece containing crude drug 23g.Usage: each l piece, every day 3 times, rectally.Started in premenstrual 4 days to stop with to the 3rd day menstrual period.L judges curative effect after the course for the treatment of.
2.2 observation items: before and after patient treatment within 24 hours menstrual period venous blood samples, through 2%EDTA-Na 2centrifugal seal after anticoagulant process ,-2O DEG C of freezing standby survey.PGF 2a, PGF 2all adopt enzymoimmunoassay.
3 therapeutic outcomes
3.1 criterions of therapeutical effect: formulate according to " new Chinese medicine guideline of clinical investigations ".Recovery from illness: after taking medicine, integration returns to 0 point, stomachache and other transference cure, drug withdrawal 3 non-recidivists of menstrual cycle; Effective: after treatment, integration is reduced to less than 1/2 of the front integration for the treatment of, and stomachache obviously alleviates, and all the other symptoms take a turn for the better, and refuses to obey that analgesic can adhere to work; Effective: after treatment, integration is reduced to l/2 ~ 3/4 of the front integration for the treatment of.Stomachache alleviates, and all the other symptoms take a turn for the better, and taking analgesic can adhere to work; Invalid: stomachache and all the other symptoms are without changer.
3.2 therapeutic outcomes: 2 groups of clinical total effectses compare, treatment group cures 15 examples, effective 10 examples, effective 4 examples, invalid 1 example, cure rate 50%, total effective rate 96.67; Matched group cures 7 examples, effective 9 examples, effective 6 examples, invalid 8 examples, cure rate 23%, total effective rate 73%.Analyze through Ridit, 2 groups of general curative effects compare, and difference has significant P<0.05.Menstrual period blood plasma PGF 2a, and PGF 2the change of ratio, in table 1.2 groups of patient PGF after treatment 2a, PGF 2all obviously reduce, compared with before treatment, difference all has significant, P<0.0l, to PGF 2a, PGF 2reducing effect, 2 groups of comparing differences without significant, P>0.05.
Table 12 group treatment front and back blood plasma PGF in menstrual period 2a, PGF 2situation of change compares
Group n Before treatment After treatment Front and back difference
Treatment group 30 4.75±1.67 1.59±1.88* 3.72±1.47&
Matched group 30 4.42±1.64 1.48±1.62* 2.22±1.40
Note: compare with before treatment, * P<0.01; Compare with matched group, & P>0.05.
4 know from experience
The pathogeny of primary dysmenorrhea is comparatively complicated, though modern medicine has been deep into molecule, cellular level to the research of primary disease, illustrates not yet completely at present.Endometrium is the significant points of synthesis of prostaglandins, and many evidences show, endometrium synthesis and release prostaglandin increase, be primary dysmenorrhea focus on reason; And PGF in most of primary dysmenorrhea women peripheral blood 2a, PGF 2ratio significantly raises.The traditional Chinese medical science is thought, dysmenorrhea morbidity has void to have reality, the void of the QI and blood Liver and kidney of the many duties of empty person, the stagnation of QI of the many duties of real person and cold, heat, damp invasion and attack.For cold and stagnate, qi stagnation and blood stasis type primary dysmenorrhea common in clinical, the author's employing take dispelling cold by warming the meridian, promoting flow of QI and blood as the suppository in treatment of the present invention of the main principles of formulating prescriptions, Herba Asari in side, Cortex Cinnamomi, Fructus Evodiae are the product of the large heat of great Xin, function cold expelling analgesic therapy: the blood stasis-eliminating and stagnation-dissipatings such as Radix Angelicae Sinensis, the Radix Paeoniae Alba, Flos Carthami, Olibanum, Myrrha, Sanguis Draxonis; Heavy dose of application drug for invigorating blood circulation and eliminating stasis, through clinical observation, can't making through amount showed increased, even if at ordinary times through measuring too much patient, help with Herba Leonuri, getting the pharmacological action that it shrinks uterus, excited uterus, can make to reduce through amount; Rhizoma Corydalis promoting the circulation of QI to relieve pain, effect is excellent compared with Rhizoma Cyperi, the Radix Linderae.Scorpio spasmolytic, for controlling dysmenorrhea, effect is significantly same.This clinical study results display, suppository cure rate of the present invention is higher than Suppository of Indomethacin, but both all can reduce PGF in primary dysmenorrhea peripheral blood in patients 2a, PGF 2ratio, as the reason of suppository cure rate of the present invention higher than Suppository of Indomethacin, may be because indometacin is a kind of chemical substance, act on prostaglandin synthetase and suppress prostaglandin to synthesize, the present invention then has many-sided pharmacological action.
Specific embodiment: rich certain, 27 years old, readme menophania started i.e. dysmenorrhea, leukorrhagia more than 2 years.Over nearly 1 year, HUANGBAI(sic) leukorrhagia is serious, and taste is smelt as of rotten fish, waist abdomen pendant pain, and before menses mistake, the dim matter of color is dense, and 10d side is clean, and through presensation perineum and abdominal part distending pain, shape, as given birth to a child, painedly to can't bear, and can must alleviate with tablet for alleviating pain.Patient's red tongue, yellow and thin fur, thready and rapid pulse string.Gynecologial examination: pudendum is presentation, vaginal congest, rotten in cervix uteri lower lip, thicken tenderness on the right side of adnexa, palace body normal in size, leucorrhea microscopy: erythrocyte (+), pyocyte (+++), card belongs to the heresy stagnant dai channel of a specified duration of turbid damp, stagnation of blood stasis and heat becomes blood stasis type dysmenorrhea, control suitable dampness, heat clearing away, dampness removing.Use following formula: Spica Prunellae, Fructus Evodiae, the Radix Angelicae Dahuricae, Cortex Cinnamomi, Herba Menthae, Herba Asari, Radix Scutellariae, Eupolyphaga Seu Steleophaga, Herba Patriniae, Herba Epimedii, Flos Carthami, Radix Angelicae Sinensis, Herba Leonuri, Folium Artemisiae Argyi, Rhizoma Corydalis, Caulis Sargentodoxae, Radix Paeoniae Rubra, the Radix Linderae, Flos Campsis, Radix Curcumae, Rhizoma Chuanxiong, Caulis Spatholobi, Cortex Moutan, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae, each 15g makes suppository.After menstrual phase, by drug suppository removing cabinet of the present invention, take out stype, pull-out afterbody cotton thread, stype is included in vagina deep, cotton thread is stayed external, and 1 every night, morning next day plays pull-out tampon, and continuous use 7 days is a course for the treatment of.Be used in conjunction 4 courses for the treatment of.4 courses for the treatment of take effect.Gradually feel that leukorrhagia reduces, color turns light, and waist abdomen pendant pain obviously alleviates, and re-uses three convalesces course for the treatment of of this Chinese medicine preparation.

Claims (10)

1. treat the Chinese medicine suppository of dysmenorrhea for one kind, it is characterized in that, described Chinese medicine suppository comprises the crude drug of following parts by weight: Spica Prunellae 10 ~ 20 parts, Fructus Evodiae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts.
2. treat the Chinese medicine suppository of dysmenorrhea according to claim 1, it is characterized in that, described Chinese medicine suppository comprises the crude drug of following parts by weight: Spica Prunellae 10 ~ 15 parts, Fructus Evodiae 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Cortex Cinnamomi 10 ~ 15 parts, Herba Menthae 10 ~ 15 parts, Herba Asari 10 ~ 15 parts, Radix Scutellariae 10 ~ 15 parts, Eupolyphaga Seu Steleophaga 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Herba Epimedii 10 ~ 15 parts, 10 ~ 15 parts, Flos Carthami, Radix Angelicae Sinensis 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Folium Artemisiae Argyi 10 ~ 20 parts, Rhizoma Corydalis 10 ~ 20 parts, Caulis Sargentodoxae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, the Radix Linderae 10 ~ 20 parts, Flos Campsis 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Caulis Spatholobi 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Achyranthis Bidentatae 10 ~ 20 parts.
3. treat the Chinese medicine suppository of dysmenorrhea according to claim 1, it is characterized in that, described Chinese medicine suppository comprises the crude drug of following parts by weight: Spica Prunellae 10 ~ 20 parts, Fructus Evodiae 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Cortex Cinnamomi 10 ~ 20 parts, Herba Menthae 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Scutellariae 10 ~ 20 parts, Eupolyphaga Seu Steleophaga 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Herba Epimedii 10 ~ 20 parts, 10 ~ 20 parts, Flos Carthami, Radix Angelicae Sinensis 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Folium Artemisiae Argyi 10 ~ 15 parts, Rhizoma Corydalis 10 ~ 15 parts, Caulis Sargentodoxae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 15 parts, the Radix Linderae 10 ~ 15 parts, Flos Campsis 10 ~ 15 parts, Radix Curcumae 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Caulis Spatholobi 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Radix Achyranthis Bidentatae 10 ~ 15 parts.
4. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine suppository of dysmenorrhea, it is characterized in that, the preparation process in described Chinese medicine suppository comprises:
A, get the Radix Linderae, Cortex Cinnamomi, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari and the Herba Menthae way of distillation and be vaporized into crystalline particle;
B, again all the other crude drug are put into soak with ethanol, heat is extracted 2 times, is component 1;
C, then by the medicinal residues extracting in water 2 times that above-mentioned steps is extracted, be component 2;
D, finally by also 2-in-1 to component 1 and component; Add the crystalline particle after vaporization to stir, put into substrate Mixer pot and set type, ultraviolet is killed virus.
5. treat the preparation method of the Chinese medicine suppository of dysmenorrhea according to claim 4, it is characterized in that, in described step a, the Radix Linderae, Cortex Cinnamomi, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari and Herba Menthae are cut into fine grained, then with steaming process distillation, crystalline particle is vaporized into, stand-by after pulverizing.
6. treat the preparation method of the Chinese medicine suppository of dysmenorrhea according to claim 4, it is characterized in that, in described step b, surplus stock medicine is added in the ethanol accounting for its quality 5-10 times amount and soaks 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use is component 1.
7. treat the preparation method of the Chinese medicine suppository of dysmenorrhea according to claim 4, it is characterized in that, in described step c, the medicinal residues of crude drug said extracted crossed add water, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, obtain component 2.
8. treat the preparation method of the Chinese medicine suppository of dysmenorrhea according to claim 4, it is characterized in that, in described steps d, above-mentioned two kinds of components are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.35 extractum, reclaim ethanol, add the crystalline particle after vaporization and stir, choose substrate 50 DEG C ~ 60 DEG C heating and melting, described suppository substrate used is selected from: one or more in semi-synthetic fatty acid glyceride, poloxamer, Polyethylene Glycol, lanoline; Described substrate is heating and melting under DEG C condition of temperature 50 C ~ 60, adds the medicine mastic that described preparation method is obtained, and stirring in water bath is even, is mixed into the liquid of thickness, is poured in plastic shape-forming pipe, and insert tampon, cooling and shaping makes bullet-shaped suppository; Described tampon is the tampon of afterbody with cotton thread.
9. according to any one of claims 1 to 3, treat a preparation method for the Chinese medicine suppository of dysmenorrhea, it is characterized in that, the preparation process of described Chinese medicine suppository also can be:
A, get the Radix Linderae, Cortex Cinnamomi, Sanguis Draxonis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Asari and Herba Menthae distillation be vaporized into crystalline particle;
B, get all the other crude drug and put into water and soak, heat is extracted 2 times, becomes extractum;
C, the crystalline particle of vaporization is pulverized after add in the extractum that above-mentioned steps obtains, put into substrate Mixer pot and set type, after ultraviolet sterilization, fill becomes suppository.
10. treat the preparation method of the Chinese medicine suppository of dysmenorrhea according to claim 9, it is characterized in that, in described step b, get the roguing of surplus stock medicine, dry, be ground into granule, soak 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, and get twice decocting liquid mixing, filtration, inserts the filtrate of filtration in economic benefits and social benefits vacuum concentrator, and when being concentrated into 80 DEG C, density is the concentrated solution of 1.25, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator stand-by again.
CN201410699234.XA 2014-11-27 2014-11-27 Traditional Chinese medicine suppository for treating dysmenorrhea and preparation method of traditional Chinese medicine suppository Pending CN104667170A (en)

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CN103721131A (en) * 2013-12-30 2014-04-16 青岛恒波仪器有限公司 Traditional Chinese medicinal suppository for treating female chronic pelvic inflammation and preparation method thereof
CN103736030A (en) * 2014-01-20 2014-04-23 上海中医药大学附属龙华医院 Traditional Chinese medicine compound formulation for treating dysmenorrhea as well as preparation method and use of formulation
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CN103721131A (en) * 2013-12-30 2014-04-16 青岛恒波仪器有限公司 Traditional Chinese medicinal suppository for treating female chronic pelvic inflammation and preparation method thereof
CN103736030A (en) * 2014-01-20 2014-04-23 上海中医药大学附属龙华医院 Traditional Chinese medicine compound formulation for treating dysmenorrhea as well as preparation method and use of formulation
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