CN117159674A - A gynecological traditional Chinese medicine composition for treating dampness-heat stasis syndrome - Google Patents

Abstract

The invention discloses a gynecological traditional Chinese medicine composition for treating damp-heat stasis syndrome, which includes soybean root, dandelion, Polygonum cuspidatum, Millet Spatholobus, Ligusticum chuanxiong, Salvia miltiorrhiza, Curcuma zedoarya, Atractylodes rhizome, red peony root, Agastache rugosa and Astragalus membranaceus. The gynecological traditional Chinese medicine composition involved in the present invention has the effects of removing dampness and heat, promoting blood circulation and removing blood stasis, and can be used to treat chronic pelvic inflammatory disease, sequelae of pelvic inflammatory disease, repeated transplantation failure, fallopian tube effusion, intrauterine adhesions, and endometrial blood perfusion. Diseases such as dysmenorrhea, thin endometrium, adenomyosis, secondary dysmenorrhea, infertility, ovarian cysts, ovulation induction and prevention of pelvic adhesions after gynecological surgery. The invention also protects the enema liquid, rectal administration preparations and their applications made from the traditional Chinese medicine composition.

Description

A gynecological traditional Chinese medicine composition for treating damp-heat stasis syndrome

Technical field

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a gynecological traditional Chinese medicine composition for treating damp-heat stasis syndrome, its enema solution and rectal administration preparation.

Background technique

Pelvic inflammatory disease refers to inflammatory diseases of the female upper reproductive tract and surrounding tissues, including endometritis and fallopian tube and ovarian cysts. If the acute phase is not healed, it will develop into chronic disease, leading to chronic pelvic pain, fallopian tube pregnancy, and even infertility. Antibiotics are often used in clinical treatment, but chronic pelvic inflammatory disease is mostly mixed infections. The therapeutic effect of a single antibiotic is not good, and long-term use of antibiotics can easily lead to drug resistance and bacterial imbalance, and the recurrence rate is high.

Oral administration of traditional Chinese medicine has a first-pass elimination effect, which affects the effectiveness of the medicine. Existing enema drugs on the market can easily cause diarrhea, allergies and other adverse reactions due to issues with compatibility and dosage forms.

Contents of the invention

The first object of the present invention is to provide a gynecological traditional Chinese medicine composition for preparing drugs for treating damp-heat stasis syndrome, including soybean root, dandelion, Polygonum cuspidatum, Millet Spatholobus, Chuanxiong rhizome, Salvia miltiorrhiza, Curcuma zedoary, Atractylodes rhizome, and red peony root. Patchouli, raw astragalus.

1-20 parts of soybean root, 1-20 parts of dandelion, 1-30 parts of Polygonum cuspidatum, 1-20 parts of Millet Spatholobus, 1-20 parts of Chuanxiong, 1-20 parts of Salvia miltiorrhiza, 1-20 parts of Curcuma zedoary, 1-20 parts of Atractylodes. 1-20 parts of red peony root, 1-30 parts of Patchouli 1-30 parts, 1-30 parts of raw astragalus.

10 parts of soybean root, 10 parts of dandelion, 15 parts of Polygonum cuspidatum, 10 parts of Spatholobus, 10 parts of Ligusticum chuanxiong, 10 parts of Salvia miltiorrhiza, 10 parts of Curcuma zedoaria, 10 parts of Atractylodes, 10 parts of red peony root, 15 parts of Agastache rugosa, 15 parts of raw astragalus. .

The above-mentioned gynecological traditional Chinese medicine composition also includes Dai medicine Luomialianglong and Zhonghang.

1-20 parts of soybean root, 1-20 parts of dandelion, 1-30 parts of Polygonum cuspidatum, 1-20 parts of Millet Spatholobus, 1-20 parts of Chuanxiong, 1-20 parts of Salvia miltiorrhiza, 1-20 parts of Curcuma zedoary, 1-20 parts of Atractylodes. 1-20 parts of red peony root, 1-30 parts of Agastache rugosa, 1-30 parts of raw astragalus, 1-20 parts of Luobian Lianglong, and 2-10 parts of Zhonghang.

10 parts of soybean root, 10 parts of dandelion, 15 parts of Polygonum cuspidatum, 10 parts of Spatholobus, 10 parts of Ligusticum chuanxiong, 10 parts of Salvia miltiorrhiza, 10 parts of Curcuma zedoaria, 10 parts of Atractylodes, 10 parts of red peony root, 15 parts of Agastache rugosa, 15 parts of raw astragalus. , Luo Mi Lianglong 10 copies, AVIC 10 copies.

The second object of the present invention is to provide an enema liquid for preparing a gynecological traditional Chinese medicine composition for treating damp-heat stasis syndrome, which is composed of a granule box and an enema bag. The granule box has small grids, each of which is composed of a granule box and an enema bag. Small grids store the above-mentioned medicinal granules respectively.

The preparation method of enema solution is to open all the small compartments in the granule box, pour the medicine out into a suitable container, add 100~150mL warm water, stir evenly, and then pour it into the enema bag.

The temperature of warm water is 37~45℃.

The enema solution of the gynecological traditional Chinese medicine composition is used in the preparation and treatment of chronic pelvic inflammatory disease, sequelae of pelvic inflammatory disease, repeated transplantation failure, fallopian tube effusion, intrauterine adhesions, poor endometrial blood perfusion, thin endometrium, adenomyosis, secondary Application in medicines for episodic dysmenorrhea, infertility, ovarian cysts, ovulation induction and prevention of pelvic adhesions after gynecological surgery.

The third object of the present invention is to provide a rectal administration preparation of a gynecological traditional Chinese medicine composition, which is prepared by adding pharmaceutically acceptable auxiliary materials.

The Luo Mi Liang Long involved in the present invention is a Dai medicine, also known as Zhu Hibiscus.

The AVIC involved in the present invention is a Dai medicine, also known as Shuangseed Palm.

Advantages of the invention:

The invention provides a gynecological traditional Chinese medicine composition for treating dampness-heat stasis syndrome. After being made into an enema liquid, it can be used clinically to treat chronic pelvic inflammatory disease, sequelae of pelvic inflammatory disease, repeated transplantation failure, fallopian tube effusion, etc. Diseases such as fluid, intrauterine adhesions, poor endometrial blood perfusion, thin endometrium, adenomyosis, secondary dysmenorrhea, infertility, ovarian cysts, ovulation induction and prevention of pelvic adhesions after gynecological surgery have been well treated. Effect.

Herba can clear away heat and detoxify, eliminate carbuncle and expel pus; Dandelion can eliminate carbuncle and stagnation; Polygonum cuspidatum and Chicken Spatholobus can dispel wind and blood stasis, clear away heat and diuresis; Ligusticum chuanxiong and Salvia miltiorrhiza can activate blood circulation and remove blood stasis; Curcuma and Atractylodes can promote qi and remove dampness, activate blood circulation and relieve pain. Paeony clears away heat and cools blood, dissipates blood stasis and relieves pain, Patchouli dispels dampness and promotes qi, raw Astragalus replenishes qi and strengthens the surface, Luobianlianglong removes wind and detoxifies, promotes blood circulation and relieves pain, Zhonghang relieves serum heat, stimulates menstruation and astringes, all the medicines are used together to form a harmonious effect. It has the effect of clearing away heat and promoting blood circulation and removing blood stasis.

The advantage of the enema solution involved in the present invention is to reduce the first-pass effect of the liver and reduce side effects on the liver. The drug is absorbed directly into the pelvic venous plexus, with higher local drug concentration, enhanced therapeutic effect, long action time, and high bioavailability.

Detailed ways

The present invention will be further described below, but the present invention will not be limited in any way. Any transformation made based on the present invention shall fall within the protection scope of the present invention.

A gynecological traditional Chinese medicine composition for preparing drugs for treating dampness-heat stasis syndrome, including soybean root, dandelion, polygonum cuspidatum, millipede, chuanxiong, salvia, zedoary, atractylodes, red peony root, rugosa, and raw astragalus.

1-20 parts of soybean root, 1-20 parts of dandelion, 1-30 parts of Polygonum cuspidatum, 1-20 parts of Millet Spatholobus, 1-20 parts of Chuanxiong, 1-20 parts of Salvia miltiorrhiza, 1-20 parts of Curcuma zedoary, 1-20 parts of Atractylodes. 1-20 parts of red peony root, 1-30 parts of Patchouli 1-30 parts, 1-30 parts of raw astragalus.

10 parts of soybean root, 10 parts of dandelion, 15 parts of Polygonum cuspidatum, 10 parts of Spatholobus, 10 parts of Ligusticum chuanxiong, 10 parts of Salvia miltiorrhiza, 10 parts of Curcuma zedoaria, 10 parts of Atractylodes, 10 parts of red peony root, 15 parts of Agastache rugosa, 15 parts of raw astragalus. .

The above-mentioned gynecological traditional Chinese medicine composition also includes the Dai medicine Luomia Lianglong and Zhonghang, that is, it includes soyrel, dandelion, polygonum cuspidatum, millipedia, chuanxiong, salvia, zedoary, atractylodes, red peony root, agastache, and raw astragalus. , Luo Mi Lianglong and AVIC.

1-20 parts of soybean root, 1-20 parts of dandelion, 1-30 parts of Polygonum cuspidatum, 1-20 parts of Millet Spatholobus, 1-20 parts of Chuanxiong, 1-20 parts of Salvia miltiorrhiza, 1-20 parts of Curcuma zedoary, 1-20 parts of Atractylodes. 1-20 parts of red peony root, 1-30 parts of Agastache rugosa, 1-30 parts of raw astragalus, 1-20 parts of Luobian Lianglong, and 2-10 parts of Zhonghang.

10 parts of soybean root, 10 parts of dandelion, 15 parts of Polygonum cuspidatum, 10 parts of Spatholobus, 10 parts of Ligusticum chuanxiong, 10 parts of Salvia miltiorrhiza, 10 parts of Curcuma zedoaria, 10 parts of Atractylodes, 10 parts of red peony root, 15 parts of Agastache rugosa, 15 parts of raw astragalus. , Luo Mi Lianglong 10 copies, AVIC 10 copies.

The enema solution of the gynecological traditional Chinese medicine composition consists of a granule box and an enema bag. The granule box has small grids, and each small grid stores medicinal granules.

The preparation method of enema solution is to open all the small compartments in the granule box, pour the medicine out into a suitable container, add 100~150mL warm water, stir evenly, and then pour it into the enema bag.

The temperature of warm water is 37~45℃.

The rectal administration preparation of the gynecological traditional Chinese medicine composition is prepared by adding pharmaceutically acceptable excipients.

The enema solution of the gynecological traditional Chinese medicine composition is used in the preparation and treatment of chronic pelvic inflammatory disease, sequelae of pelvic inflammatory disease, repeated transplantation failure, fallopian tube effusion, intrauterine adhesions, poor endometrial blood perfusion, thin endometrium, adenomyosis, secondary Application in medicines for episodic dysmenorrhea, infertility, ovarian cysts, ovulation induction and prevention of pelvic adhesions after gynecological surgery.

The Luo Mi Liang Long involved in the present invention is a Dai medicine, also known as Zhu Hibiscus.

The AVIC involved in the present invention is a Dai medicine, also known as Shuangseed Palm.

Example 1:

10g of soybean root, 10g of dandelion, 15g of Polygonum cuspidatum, 10g of Spatholobus, 10g of Chuanxiong, 10g of Salvia miltiorrhiza, 10g of Curcuma zedoary, 10g of Atractylodes, 10g of red peony root, 15g of Patchouli 15g, and 15g of raw astragalus.

Example 2:

10g of soybean grass, 10g of dandelion, 15g of Polygonum cuspidatum, 10g of Millet Spatholobus, 10g of Chuanxiong, 10g of Salvia miltiorrhiza, 10g of Curcuma zedoary, 10g of Atractylodes, 10g of red peony root, 15g of Agastache rugosa, 15g of raw astragalus, Luomia Lianglong (Dai medicine, hibiscus) 10g, AVIC (Dai medicine, double seed palm) 10g.

Example 3:

Traditional Chinese medicine retention enema operation process:

Components of traditional Chinese medicine observation: Part 1: Granule kit. The traditional Chinese medicine particles described in Example 1 are contained in the medicine box. What is in a box is a single amount. Open all the small compartments in the box, pour the medicine out into a suitable container, and add 100~150mL of warm water, which is slightly above body temperature but not hot. Part 2: Enema bag (similar to an infusion bag).

Steps: (1) Completely close the valve of the enema bag (the position where the infusion bag usually adjusts the number of drops); (2) Pour the medicine mixed with warm water in the first part from the upper opening of the enema bag (provided that it is completely (Close the valve); (3) The person should lie down on his back or side, hang the enema bag higher than the person's level, apply lubricant (Vaseline, glycerin, etc.) to the 10~15cm end tube of the enema bag, and then slowly Put the tube into the anus (not the vagina), slowly open the valve of the enema bag, and let all the prepared medicine flow into the body. (4) After the drug enters the body, try to lie on the bed to keep the drug in the body for at least 30 minutes. If done well, it can be retained until the next morning and can be excreted when going to the bathroom. (5) If you keep the medicine until the second day and go to the bathroom and find that your stool is watery, don’t be nervous. It is normal.

Precautions

1. When inserting into the anal canal, the action must be gentle. If the patient feels discomfort or resistance, gently massage the area around the anus. After it is relaxed or there is no resistance, insert slowly and do not insert forcefully.

2. When squeezing the enema bag to inject the liquid, do so slowly and at a constant speed, and closely observe the patient's reaction. If there is any discomfort, slow down the injection speed or pause the injection. After the patient's discomfort disappears, slowly squeeze and inject again.

3. During the enema period, the patient's reaction should be closely observed. If the patient develops symptoms such as paleness, palpitation, sweating, dizziness, etc., the operation should be stopped immediately and symptomatic treatment should be provided.

4. After the enema operation is completed, the patient should remain in a lying position and continue to observe. It is recommended that the patient be accompanied by someone.

5. If the patient suffers from hemorrhoids, special attention should be paid to preventing bleeding during the operation. In the acute attack of hemorrhoids or if the symptoms are severe, enema treatment will not be given temporarily.

Clinical efficacy evaluation:

The self-made enema prescription for removing dampness and blood stasis has been preliminarily confirmed to improve the pelvic sign scale (McCormack) scores, McGill pain scale scores, TCM syndrome scores, and serum inflammatory factor levels in patients with chronic pelvic inflammatory disease. The report is as follows.

1Clinical data

1.1 General information

Recruitment from the Department of Reproductive Medicine of the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, the Acupuncture Department of the First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, and the Reproductive Department of the Second People's Hospital of Yunnan Province from January 1, 2019 to March 30, 2023. and patients in the inpatient department who met the diagnostic criteria for chronic pelvic inflammatory disease and whose TCM syndrome was dampness-heat and blood stasis syndrome were randomly divided into a control group and a traditional Chinese medicine group, 30 cases each, for a total of 60 cases.

1.2 Diagnostic criteria

(1) Western medicine diagnostic criteria: in line with the diagnostic criteria of chronic pelvic inflammatory disease in "Obstetrics and Gynecology": past history of acute pelvic inflammatory disease; accompanied by lower abdominal distension, pain and lumbosacral soreness; irregular menstruation, excessive leucorrhea, and odor; uterus Limited movement or fixed adhesions are accompanied by tenderness and tenderness in the adnexal area; ultrasound examination can detect thickening of the fallopian tubes, pelvic effusion or pelvic inflammatory mass.

(2) TCM syndrome differentiation standards: Damp-heat stasis syndrome syndrome differentiation standards: Main symptoms: distending pain or tingling in the lumbosacral region and lower abdomen; vaginal discharge with yellow color and large amount; secondary symptoms: dyspareunia; low-grade fever; aggravation of abdominal pain during menstruation, and prolonged menstruation , heavy menstruation, blood clots; yellow urine; dry stool or loose stools; bitter mouth and dry throat; drowsiness in the limbs, dark purple tongue, ecchymosis, yellow and greasy coating, and slippery and rapid pulse. The main symptoms are required, and at least 2 of the secondary symptoms must be met. The syndrome of dampness, heat and blood stasis can be diagnosed by referring to the tongue and pulse.

1.3 Inclusion criteria

① Meet the above diagnostic criteria; ② Aged 24 to 45 years old; ③ Can tolerate enema treatment; Have no barriers to cognition and communication, and can cooperate with relevant investigations, diagnosis and treatment.

1.4 Exclusion criteria

①Combined with other pelvic diseases such as pelvic tuberculosis and tumors; Those who are combined with other systemic diseases and have bad habits such as smoking and drinking.

2 treatments

2.1 Control group

Levofloxacin hydrochloride tablets, 0.4 g each time, once a day, and metronidazole tablets (China Resources Shuanghe Limin Medicine, 0.4 g each time, once a day) were given orally for 14 consecutive days as a course of treatment.

2.2 Observation group

On the basis of the control group, enema prescription for removing dampness and blood stasis was given. Add 100~150mL warm water to brew the drug granules, slightly higher than body temperature but not hot, put the medicine into the enema bag, instruct the patient to lie on his side after emptying his bowels, raise his buttocks by 5~10cm, and place the disposable After the tube is lubricated, gently insert it into the anus 14 to 15 cm, and instill it at a rate of 60 to 70 drops per minute. After the end of the treatment, the patient is asked to continue to stay in the lateral position for 20 to 30 minutes, once a day, for 14 consecutive days as a course of treatment.

3. Curative effect observation

3.1 Observation indicators

3.1.1 Main outcome indicators

(1) Use the Pelvic Sign Scale (McCormack) to evaluate abdominal tenderness or rebound tenderness, uterine tenderness, cervical swing pain, adnexal area tenderness, etc. before and after treatment from 0 to 3 points. The higher the score, the more severe the pain.

(2) Use the McGill Pain Scale to evaluate the pain emotion and pain level before and after treatment from 0 to 3 points. The higher the score, the more severe the pain.

3.1.2 Secondary outcome indicators

(1) TCM syndrome score: Evaluate the TCM syndrome scores of the two groups before and after treatment. The higher the score, the more severe the patient's symptoms are.

(2) Inflammation level: ELISA was used to detect the level of interleukin-6 (IL-6).

3.2 Safety evaluation

Promptly and effectively deal with safety issues during patient treatment (such as adverse drug reactions, etc.).

3.3 Statistical processing

SPSS26.0 software was used for statistical analysis. If the measurement data met the normal distribution, the mean ± standard was used.

Difference (x ± s) is expressed, and the paired sample t test is used for intra-group comparison, and the two independent samples t test is used for comparison between groups; count data is expressed as frequency or percentage (%), and ^χ2 test is used. P <0.05 was considered as a statistically significant difference. (The subscript (1) indicates that the before and after comparison within the group is statistically significant, and the subscript (2) indicates that the comparison between the groups after treatment is statistically significant)

3.4 Results

(1) Comparison of general information between the two groups of patients

There was no statistically significant difference in general data such as age, pelvic sign scale, McGill pain scale, TCM syndrome score, and serum IL-6 levels between the two groups ( P > 0.05), and they were comparable, see Table 1.

Table 1 Comparison of general information of the two groups of patients

(2) Comparison of the pelvic sign scale and McGill pain scale between the two groups of patients before and after treatment

After treatment, the pelvic sign scale scores of the two groups of patients were lower than before treatment ( P <0.05), and the pelvic sign scale scores of the observation group were significantly lower than those of the control group ( P <0.05); the McGill pain scale scores of the two groups were significantly lower after treatment. It was lower than before treatment ( P <0.05), and the McGill pain scale of the observation group was significantly lower than that of the control group ( P <0.05), see Table 2.

Table 2 Comparison of pelvic sign scale and McGill pain scale between two groups of patients before and after treatment

Note: Compared with this group before treatment, ⁽¹⁾ P <0.05; compared with the control group after treatment, ⁽²⁾ P <0.05.

(3) Comparison of TCM syndrome scores between the two groups of patients before and after treatment

After treatment, the TCM syndrome scores of the two groups of patients were lower than before treatment ( P <0.05), and the TCM syndrome scores of the observation group after treatment were lower than those of the control group ( P <0.05). See Table 3 for details.

Table 3 Comparison of TCM syndrome scores between the two groups of patients before and after treatment

Note: Compared with this group before treatment, ⁽¹⁾ P <0.05; compared with the control group after treatment, ⁽²⁾ P <0.05.

(4) Comparison of serum inflammation levels between the two groups of patients

After treatment, the serum inflammatory index IL-6 of the two groups of patients was lower than before treatment ( P <0.05), and the TCM syndrome score of the observation group after treatment was lower than that of the control group ( P <0.05). See Table 4 for details.

Table 4 Comparison of serum inflammation levels between the two groups of patients

Note: Compared with this group before treatment, ⁽¹⁾ P <0.05; compared with the control group after treatment, ⁽²⁾ P <0.05.

in conclusion

The results of this study show that Huashi Quyu enema prescription can effectively reduce the pelvic sign scale and McGill pain scale scores in patients with chronic pelvic inflammatory disease, improve the clinical symptoms of patients with damp-heat stasis, reduce serum inflammation levels, and relieve the symptoms of chronic pelvic inflammatory disease.

Claims (10)

1. A gynecological traditional Chinese medicine composition for preparing drugs for treating damp-heat stasis syndrome, which is characterized in that it includes soybean root, dandelion, Polygonum cuspidatum, Milla sinensis, Ligusticum chuanxiong, Salvia miltiorrhiza, Curcuma zedoary, Atractylodes rhizome, red peony root, and Agastache rugosa. , raw astragalus. 2. The gynecological traditional Chinese medicine composition as claimed in claim 1, characterized in that it includes 1-20 parts of Ligusticum sibiricum, 1-20 parts of Dandelion, 1-30 parts of Polygonum cuspidatum, 1-20 parts of Millaplasia sinensis, and 1-20 parts of Ligusticum Chuanxiong. 20 parts, 1-20 parts of salvia, 1-20 parts of Curcuma, 1-20 parts of Atractylodes, 1-20 parts of red peony root, 1-30 parts of Patchouli, 1-30 parts of raw astragalus. 3. The gynecological traditional Chinese medicine composition as claimed in claim 1, characterized in that it includes 10 parts of Sophora sinensis, 10 parts of Dandelion, 15 parts of Polygonum cuspidatum, 10 parts of Spatholobus, 10 parts of Chuanxiong, 10 parts of Salvia miltiorrhiza and 10 parts of Curcuma. , 10 parts of Atractylodes, 10 parts of red peony root, 15 parts of Patchouli, and 15 parts of raw astragalus. 4. The gynecological traditional Chinese medicine composition as claimed in claim 1, characterized in that it includes soybean root, dandelion, Polygonum cuspidatum, Millet Spatholobus, Ligusticum chuanxiong, Salvia miltiorrhiza, Curcuma zedoary, Atractylodes rhizome, red peony root, Agastache rugosa, Astragalus membranaceus, Radix Spatholobus. Lianglong, AVIC. 5. The gynecological traditional Chinese medicine composition as claimed in claim 4, characterized in that it includes 1-20 parts of Ligusticum sibiricum, 1-20 parts of Dandelion, 1-30 parts of Polygonum cuspidatum, 1-20 parts of Millet Spatholobus, and 1-20 parts of Ligusticum Chuanxiong. 20 parts, Salvia miltiorrhiza 1-20 parts, Curcuma zedoaria 1-20 parts, Atractylodes 1-20 parts, Red peony root 1-20 parts, Agastache rugosa 1-30 parts, Raw Astragalus 1-30 parts, Luobian Lianglong 1-20 parts , AVIC 2-10 copies. 6. The gynecological traditional Chinese medicine composition as claimed in claim 4, characterized in that it includes 10 parts of Sophora sinensis, 10 parts of Dandelion, 15 parts of Polygonum cuspidatum, 10 parts of Spatholobus, 10 parts of Chuanxiong, 10 parts of Salvia miltiorrhiza and 10 parts of Curcuma. , 10 parts of Cangzhu, 10 parts of red peony root, 15 parts of Patchouli, 15 parts of raw astragalus, 10 parts of Luobian Lianglong, and 10 parts of Avic. 7. An enema liquid based on the gynecological traditional Chinese medicine composition according to claim 1 or 4, characterized in that it is composed of a granule medicine box and an enema bag. There are small grids in the granule medicine box, and each small grid is stored separately. Medicinal granules. 8. The preparation method of enema liquid as claimed in claim 7, characterized in that all small compartments in the granule medicine box are opened, the medicine is poured out and placed in a suitable container, and 100~150mL 37~45 ℃ warm water, stir evenly and pour into the enema bag. 9. A rectal administration preparation based on the gynecological traditional Chinese medicine composition according to claim 1 or 4, characterized in that it further includes pharmaceutically acceptable auxiliary materials to form a rectal administration preparation. 10. The enema as claimed in claim 7 is useful in preparing and treating chronic pelvic inflammatory disease, sequelae of pelvic inflammatory disease, repeated transplantation failure, fallopian tube effusion, intrauterine adhesions, poor endometrial blood perfusion, thin endometrium, and uterine glands. Application of drugs in myopathy, secondary dysmenorrhea, infertility, ovarian cysts, ovulation induction and prevention of pelvic adhesions after gynecological surgery.