CN102210814A - Chinese medicinal composition for treating chronic prostatitis and preparation method thereof - Google Patents
Chinese medicinal composition for treating chronic prostatitis and preparation method thereof Download PDFInfo
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- CN102210814A CN102210814A CN2010101384689A CN201010138468A CN102210814A CN 102210814 A CN102210814 A CN 102210814A CN 2010101384689 A CN2010101384689 A CN 2010101384689A CN 201010138468 A CN201010138468 A CN 201010138468A CN 102210814 A CN102210814 A CN 102210814A
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- 238000002360 preparation method Methods 0.000 title abstract description 3
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- 239000003814 drug Substances 0.000 claims description 24
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- 239000012141 concentrate Substances 0.000 claims description 12
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese medicinal composition for treating chronic prostatitis and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The composition is prepared from medicinal materials, such as phellodendron amurense, giant knotweed and the like and has an excellent effect.
Description
Technical field
The present invention is a kind of Chinese medicine composition for the treatment of chronic prostatitis and preparation method thereof, belongs to technical field of Chinese medicine.
Technical background
Non-specific chronic prostatitis serves as main performance with urinary tract symptom, prostate tenderness and massage of prostate liquid unusually, and characteristics such as state of an illness complexity, touching difficulty heal, easy recurrence are arranged.Be mainly in the 20-40 person between twenty and fifty in year.According to statistics, there is 50% man suffering from prostatitis in life approximately.And 95% be non-specific chronic prostatitis wherein.
Because the pathological characteristic of distinctive anatomical structure of prostate and chronic prostatitis makes very difficulty of its treatment.Antibacterials commonly used are difficult for entering prostate under the inflammation situation, the drug resistance of antibacterial, pathogen, microorganism also is the obstacle that antibiotic can't be gone beyond, and general antibacterial therapy method is difficult to prove effective, and can not fundamentally effect a radical cure this disease.
The patient is because malpractice, and the state of an illness is shown effect repeatedly, and hepatic and renal function is impaired, and function disorder, immunologic function degression, complication are all risen, bacterium drug resistance drug resistance in addition, and variation is hidden, and forms vicious cycle, has caused greatest painful and injury for patient's body and mind.Therefore, adopting a kind of can no longer the recurrence from going up the non-specific chronic prostatitis of thorough healing for this, can not cause the medicine of hepatorenal damage again, is the key of curing non-specific chronic prostatitis.
Primary disease belongs to the traditional Chinese medical science " smart turbid ", " stranguria caused by overstrain ", " excessive in vain " category, as have in clear what dream precious jade " doctor's rock reddish and whitish turbid urine " piece of writing " the key end lead often silk ribbon greasy, as pus such as gum ", the urine later and decadent stage of a school of thought that resembles very much primary disease is white.In view of such circumstances, providing a kind of determined curative effect, toxic and side effects Chinese medicine composition little, taking convenience is the thing of being badly in need of solution.
Summary of the invention
Technical problem to be solved by this invention provides a kind of Chinese medicine composition and method for making for the treatment of chronic prostatitis; The present invention is directed to prior art, little, the taking convenience of product determined curative effect, toxic and side effects that provides.
Technical scheme of the present invention is to constitute like this: it is made up of following active drug raw material: Cortex Phellodendri 200-350g, Rhizoma Polygoni Cuspidati 150-300g, Herba Polygoni Avicularis 150-300g, Herba Dianthi 150-300g, Rhizoma Imperatae 150-250g, Flos Chrysanthemi Indici 150-250g, Herba Epimedii 120-180g, Semen Plantaginis 120-180g.Be preferably: Cortex Phellodendri 250-300g, Rhizoma Polygoni Cuspidati 200-250g, Herba Polygoni Avicularis 200-250g, Herba Dianthi 200-250g, Rhizoma Imperatae 180-220g, Flos Chrysanthemi Indici 180-220g, Herba Epimedii 140-165g, Semen Plantaginis 140-165g.Best of breed: Cortex Phellodendri 289g, Rhizoma Polygoni Cuspidati 235.5g, Herba Polygoni Avicularis 236.5g, Herba Dianthi 236.5g, Rhizoma Imperatae 210g, Flos Chrysanthemi Indici 210g, Herba Epimedii 158g, Semen Plantaginis 158g.
The method for making of the Chinese medicine composition of described treatment chronic prostatitis: the raw material of getting it filled, pulverize or extract, make multiple peroral dosage form then respectively, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.Elect as: Herba Epimedii adds ethanol 1-3 time, and each 1-3 hour, the ethanol consumption was 3-8 a times of medical material, and collecting decoction filters, and filtrate recycling ethanol is not distinguished the flavor of to there being alcohol, and is standby; Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Herba Polygoni Avicularis, Herba Dianthi, Rhizoma Imperatae, Flos Chrysanthemi Indici, Semen Plantaginis and the Herba Epimedii behind ethanol extraction decoct with water 1-5 time, each 1-3 hour, each amount of water be medical material 6-10 doubly, collecting decoction filters, filtrate concentrates, and adds ethanol to containing the alcohol amount for 20-80%, leaves standstill 12-36 hour, filter, filtrate recycling ethanol mixes with the extracting solution of Herba Epimedii to there not being the alcohol flavor, concentrates, make multiple peroral dosage form then respectively, comprising: tablet, capsule, granule.
Select Cortex Phellodendri in the side for use, it is cold to win heat to get its bitter in the mouth, bitter with dampness, is apt to clear damp-heat in lower-JIAO and consolidating YIN.Semen Plantaginis is sweet cold sliding sharp, and diuretic also can heat clearing away.Shennong's Herbal carries Semen Plantaginis: " main stranguria due to disorder of QI, pain relieving, dredging water passages urine ...." the Herba Dianthi bitter cold, be the product of sedimentation catharsis, clear away heart-fire and small intestinal, damp-heat in the urinary bladder, go into blood system partially and can invigorate blood circulation, the middle latent heat that purifies the blood, diuresis and heat conduction is descending.Shennong's Herbal carries it: " all infirmity knots of main obstruction and rejection, urinary obstruction.” Herba Polygoni Avicularis hardship is fallen row, can clear damp-heat in lower-JIAO and relieving stranguria by diuresis.Four medicines phase 5, clearing away heat-fire, relieving stranguria by diuresis is monarch drug altogether.Ministerial drug is selected Rhizoma Polygoni Cuspidati for use, and bitter in the mouth is cold, clearing away heat-damp and promoting diuresis is arranged, the effect of the analgesic therapy of detoxifying, invigorate blood circulation.Strengthen the merit of the clearing away heat-damp and promoting diuresis detoxifcation of monarch drug.Assistant is with the Flos Chrysanthemi Indici heat-clearing and toxic substances removing; The Rhizoma Imperatae clearing away heat and promoting diuresis, cooling blood for hemostasis.The same usefulness of medicine had both strengthened the merit of clearing away heat-damp and promoting diuresis detoxifcation, can remove the effect of stasis of blood hemostasis analgesic therapy again.The hot temperature of Herba Epimedii, fitting in the bitter and cold medicines is to be using corrigent, can prevent bitter cold damaging the spleen and stomach and the damp and hot heresy of ice volt, helps dehumidifying to end the power of pouring again.All medicines share, and play the effect of clearing away heat-damp and promoting diuresis, relieving stranguria by diuresis, detoxifcation altogether.
Pharmacodynamic experiment is the result show, this product has inhibitory action to male rat aseptic prostatitis due to the xiaozhiling injection, make that the lecithin corpusculum obviously increases in the prostate, total white blood cells obviously reduces, the acid phosphatase that inflammation-inhibiting causes raises, the prostate adenomatosis is clearly better, and a matter inflammatory cell infiltration obviously alleviates; Can alleviate the bullate granulation weight of cotton balls bud.Dichlorodiphenyl Acetate causes the capillary permeability increase of mice chamber obvious inhibitory action; Can resist the mouse writhing reaction that acetic acid causes.
Concrete embodiment
Embodiment 1: Cortex Phellodendri 289g, Rhizoma Polygoni Cuspidati 236.5g, Herba Polygoni Avicularis 236.5g, Herba Dianthi 236.5g, Rhizoma Imperatae 210g, Flos Chrysanthemi Indici 210g, Herba Epimedii 158g, Semen Plantaginis 158g
Herba Epimedii adds 60% ethanol extraction 2 times, and each 2 hours, each 60% alcoholic acid addition was 6 times of medical material, and collecting decoction filters, and filtrate recycling ethanol is to there not being the alcohol flavor, and is standby; Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Herba Polygoni Avicularis, Herba Dianthi, Rhizoma Imperatae, Flos Chrysanthemi Indici, Semen Plantaginis and the Herba Epimedii behind 60% ethanol extraction decoct with water 3 times, each 2 hours, each amount of water is 8 times of medical material, and collecting decoction filters, filtrate concentrates, and adding ethanol is 50% to containing the alcohol amount, leaves standstill 24 hours, filter, filtrate recycling ethanol mixes with the extracting solution of Herba Epimedii to there not being the alcohol flavor, concentrate, drying under reduced pressure gets dry extract, and adds starch, grinding and sieving, granulate with dehydrated alcohol, granulate, encapsulated, promptly get capsule, oral, one time 3,3 times on the one.
Embodiment 2: Cortex Phellodendri 250g, Rhizoma Polygoni Cuspidati 200g, Herba Polygoni Avicularis 200g, Herba Dianthi 200g, Rhizoma Imperatae 180g, Flos Chrysanthemi Indici 180g, Herba Epimedii 140g, Semen Plantaginis 140g
Herba Epimedii adds 40% ethanol extraction 1 hour, and the ethanol consumption is 3 times of medical material, and collecting decoction filters, and filtrate recycling ethanol is to there not being the alcohol flavor, and is standby; Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Herba Polygoni Avicularis, Herba Dianthi, Rhizoma Imperatae, Flos Chrysanthemi Indici, Semen Plantaginis and the Herba Epimedii behind ethanol extraction decoct with water 1 hour, and amount of water is 6 times of medical material, collecting decoction filters, and filtrate concentrates, adding ethanol is 20% to containing the alcohol amount, leaves standstill 12 hours, filters, filtrate recycling ethanol is to there not being the alcohol flavor, mix with the extracting solution of Herba Epimedii, concentrate drying, tabletting is remembered tablet.
Embodiment 3: Cortex Phellodendri 300g, Rhizoma Polygoni Cuspidati 250g, Herba Polygoni Avicularis 250g, Herba Dianthi 250g, Rhizoma Imperatae 220g, Flos Chrysanthemi Indici 220g, Herba Epimedii 165g, Semen Plantaginis 165g
Herba Epimedii adds 80% ethanol 3 times, and each 3 hours, the ethanol consumption was 8 times of medical material, and collecting decoction filters, and filtrate recycling ethanol is to there not being the alcohol flavor, and is standby; Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Herba Polygoni Avicularis, Herba Dianthi, Rhizoma Imperatae, Flos Chrysanthemi Indici, Semen Plantaginis and the Herba Epimedii behind ethanol extraction decoct with water 5 times, each 3 hours, each amount of water is 10 times of medical material, and collecting decoction filters, filtrate concentrates, and adding ethanol is 80% to containing the alcohol amount, leaves standstill 36 hours, filter, filtrate recycling ethanol mixes with the extracting solution of Herba Epimedii to there not being the alcohol flavor, concentrate, drying is pulverized, granulate with dehydrated alcohol, granulate promptly gets granule.
Embodiment 4: Cortex Phellodendri 200g, Rhizoma Polygoni Cuspidati 150g, Herba Polygoni Avicularis 150g, Herba Dianthi 150g, Rhizoma Imperatae 150g, Flos Chrysanthemi Indici 150g, Herba Epimedii 120g, Semen Plantaginis 120g.
Above flavour of a drug decoct with water three times, add 4 times of water gagings at every turn and decoct 2 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
Embodiment 5: Cortex Phellodendri 350g, Rhizoma Polygoni Cuspidati 300g, Herba Polygoni Avicularis 300g, Herba Dianthi 300g, Rhizoma Imperatae 250g, Flos Chrysanthemi Indici 250g, Herba Epimedii 180g, Semen Plantaginis 180g.
Above flavour of a drug decoct with water three times, add 4 times of water gagings at every turn and decoct 1.5 hours, and collecting decoction filters, and concentrates, and promptly gets oral liquid.
Claims (5)
1. Chinese medicine composition for the treatment of chronic prostatitis, it is characterized in that: it is made up of following active drug raw material: Cortex Phellodendri 200-350g, Rhizoma Polygoni Cuspidati 150-300g, Herba Polygoni Avicularis 150-300g, Herba Dianthi 150-300g, Rhizoma Imperatae 150-250g, Flos Chrysanthemi Indici 150-250g, Herba Epimedii 120-180g, Semen Plantaginis 120-180g.
2. according to the Chinese medicine composition of the described treatment chronic prostatitis of claim 1, it is characterized in that: it is made up of following active drug raw material: Cortex Phellodendri 250-300g, Rhizoma Polygoni Cuspidati 200-250g, Herba Polygoni Avicularis 200-250g, Herba Dianthi 200-250g, Rhizoma Imperatae 180-220g, Flos Chrysanthemi Indici 180-220g, Herba Epimedii 140-165g, Semen Plantaginis 140-165g.
3. according to the Chinese medicine composition of the described treatment chronic prostatitis of claim 2, it is characterized in that: it is made up of following active drug raw material: Cortex Phellodendri 289g, Rhizoma Polygoni Cuspidati 236.5g, Herba Polygoni Avicularis 236.5g, Herba Dianthi 236.5g, Rhizoma Imperatae 210g, Flos Chrysanthemi Indici 210g, Herba Epimedii 158g, Semen Plantaginis 158g.
4. according to the method for making of the Chinese medicine composition of any described treatment chronic prostatitis of claim 1-3, it is characterized in that: the raw material of getting it filled, pulverize or extract, make multiple peroral dosage form then respectively, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.
5. according to the method for making of the Chinese medicine composition of the described treatment chronic prostatitis of claim 4, it is characterized in that: Herba Epimedii adds ethanol 1-3 time, each 1-3 hour, the ethanol consumption is 3-8 a times of medical material, and collecting decoction filters, filtrate recycling ethanol is to there not being the alcohol flavor, and is standby; Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Herba Polygoni Avicularis, Herba Dianthi, Rhizoma Imperatae, Flos Chrysanthemi Indici, Semen Plantaginis and the Herba Epimedii behind ethanol extraction decoct with water 1-5 time, each 1-3 hour, each amount of water be medical material 6-10 doubly, collecting decoction filters, filtrate concentrates, and adds ethanol to containing the alcohol amount for 20-80%, leaves standstill 1236 hours, filter, filtrate recycling ethanol mixes with the extracting solution of Herba Epimedii to there not being the alcohol flavor, concentrates, make multiple peroral dosage form then respectively, comprising: tablet, capsule, granule.
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| CN2010101384689A CN102210814A (en) | 2010-04-02 | 2010-04-02 | Chinese medicinal composition for treating chronic prostatitis and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103134894A (en) * | 2011-11-25 | 2013-06-05 | 张金荣 | Detecting method of traditional Chinese medicine compositions for treating chronic prostatitis |
| CN103134896A (en) * | 2011-11-25 | 2013-06-05 | 张金荣 | Detection method for Chinese materia medica preparation for treating chronic prostatitis |
| CN103134895A (en) * | 2011-11-25 | 2013-06-05 | 张金荣 | Identification method for compound golden cypress agent |
| CN104189658A (en) * | 2014-06-11 | 2014-12-10 | 习文忠 | Traditional Chinese medicine composition treating impotence caused by prostatitis |
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|---|---|---|---|---|
| CN1799595A (en) * | 2005-06-11 | 2006-07-12 | 孙治林 | Chinese medicinal formulation for treating urogenital system disease |
| CN101375988A (en) * | 2008-09-27 | 2009-03-04 | 曹开镛 | Anti-inflammation formulation for treating acute prostatitis and preparation method thereof |
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2010
- 2010-04-02 CN CN2010101384689A patent/CN102210814A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1799595A (en) * | 2005-06-11 | 2006-07-12 | 孙治林 | Chinese medicinal formulation for treating urogenital system disease |
| CN101375988A (en) * | 2008-09-27 | 2009-03-04 | 曹开镛 | Anti-inflammation formulation for treating acute prostatitis and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 解玉波: "中药六类新药柏杖前列腺胶囊的研究", 《中国优秀硕士学位论文数据库》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103134894A (en) * | 2011-11-25 | 2013-06-05 | 张金荣 | Detecting method of traditional Chinese medicine compositions for treating chronic prostatitis |
| CN103134896A (en) * | 2011-11-25 | 2013-06-05 | 张金荣 | Detection method for Chinese materia medica preparation for treating chronic prostatitis |
| CN103134895A (en) * | 2011-11-25 | 2013-06-05 | 张金荣 | Identification method for compound golden cypress agent |
| CN104189658A (en) * | 2014-06-11 | 2014-12-10 | 习文忠 | Traditional Chinese medicine composition treating impotence caused by prostatitis |
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