CN105497244A - Traditional Chinese medicine composition used for treating diaper dermatitis and applied to clinical care as well as preparation method - Google Patents

Traditional Chinese medicine composition used for treating diaper dermatitis and applied to clinical care as well as preparation method Download PDF

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CN105497244A
CN105497244A CN201510975256.9A CN201510975256A CN105497244A CN 105497244 A CN105497244 A CN 105497244A CN 201510975256 A CN201510975256 A CN 201510975256A CN 105497244 A CN105497244 A CN 105497244A
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parts
herba
chinese medicine
radix
medicine composition
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陈洪福
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A61K36/195—Strobilanthes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
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    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718—Coptis (goldthread)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention relates to traditional Chinese medicine composition used for treating diaper dermatitis and applied to clinical care as well as a preparation method. The traditional Chinese medicine composition comprises raw materials in parts by weight as follows: 5-10 parts of purslane herbs, 3-5 parts of gromwell roots, 2-5 parts of natural indigo, 5-7 parts of borneol, 2-5 parts of liquorice roots, 3-6 parts of heartleaf houttuynia herbs, 1-5 parts of dandelions, 2-5 parts of wild chrysanthemum flowers, 3-6 parts of chrysanthemum flowers, 2-8 parts of lotus leaves, 3-9 parts of common self-heal fruit-spike, 2-5 parts of mulberry leaves, 3-8 parts of sophora flowers, 2-5 parts of goldthread, 1-5 parts of baical skullcap roots, 2-6 parts of amur cork tree bark, 3-5 parts of honeysuckle flowers, 2-8 parts of common andrographis herbs and 5-8 parts of weeping forsythia capsules. The composition has the reliable curative effect on the diaper dermatitis.

Description

A kind of Chinese medicine composition of clinical care treatment diaper dermatitis and preparation method
Technical field
The invention belongs to medical art, be specifically related to Chinese medicine composition of a kind of clinical care treatment diaper dermatitis and preparation method thereof.
Background technology
It is red that diaper dermatitis is commonly called as buttocks, inside multiple baby buttocks, pudendum and the stock being born in 2 ~ 3 months, is a kind of common infant contact dermatitis.The cause of disease fails to change in time due to baby diaper, or at things such as the additional Polypropylence Sheet of diaper, oilcloths, baby buttocks continuous skin is made to be in urine insult, the ammonia-producing bacterium of skin surface is by the urea decomposition ammonification in urine, stimulate thin tender skin and diaper dermatitis occurs, in addition, the soap that washing is clean, not residual directly contacts skin and also all can facilitate dermatitis.Clear-cut large stretch of erythema, pimple or rotten to the corn sepage, even secondary bacterial or monilial infection is there is in clinical manifestation at diaper position., can skin ulcer be there is in several cases, the particularly baby of malnutrition chronic diarrhea.At present, to the treatment of diaper dermatitis mainly antibiotic for oral administration or with wet packing of drugs, because children's's endo-medicine is more difficult, add Western medicine side effect large, be not suitable for child administration, external washout with traditional Chinese herbs is easy with its method, have no side effect, be particularly suitable for the treatment of pediatric diaper dermatitis.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides the Chinese medicine composition of a kind of clinical care treatment diaper dermatitis, curative effect is reliable.
The present invention is realized by following technical scheme:
A Chinese medicine composition for clinical care treatment diaper dermatitis, is made up of the raw material of following weight portion:
Herba Portulacae 5-10 part, Radix Arnebiae (Radix Lithospermi) 3-5 part, Indigo Naturalis 2-5 part, Borneolum Syntheticum 5-7 part, Radix Glycyrrhizae 2-5 part, Herba Houttuyniae 3-6 part, Herba Taraxaci 1-5 part, Flos Chrysanthemi Indici 2-5 part, Flos Chrysanthemi 3-6 part, Folium Nelumbinis 2-8 part, Spica Prunellae 3-9 part, Folium Mori 2-5 part, Flos Sophorae 3-8 part, Rhizoma Coptidis 2-5 part, Radix Scutellariae 1-5 part, Cortex Phellodendri 2-6 part, Flos Lonicerae 3-5 part, Herba Andrographis 2-8 part, Fructus Forsythiae 5-8 part.
Preferably, be made up of the raw material of following weight portion:
Herba Portulacae 10 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Indigo Naturalis 2 parts, Borneolum Syntheticum 7 parts, 2 parts, Radix Glycyrrhizae, Herba Houttuyniae 3 parts, Herba Taraxaci 5 parts, Flos Chrysanthemi Indici 5 parts, Flos Chrysanthemi 3 parts, 8 parts, Folium Nelumbinis, Spica Prunellae 3 parts, 2 parts, Folium Mori, 8 parts, Flos Sophorae, Rhizoma Coptidis 2 parts, Radix Scutellariae 5 parts, Cortex Phellodendri 2 parts, Flos Lonicerae 5 parts, Herba Andrographis 2 parts, Fructus Forsythiae 5 parts.
Preferably, be made up of the raw material of following weight portion:
Herba Portulacae 5 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Indigo Naturalis 5 parts, Borneolum Syntheticum 5 parts, 5 parts, Radix Glycyrrhizae, Herba Houttuyniae 6 parts, Herba Taraxaci 1 part, Flos Chrysanthemi Indici 2 parts, Flos Chrysanthemi 6 parts, 2 parts, Folium Nelumbinis, Spica Prunellae 9 parts, 5 parts, Folium Mori, 3 parts, Flos Sophorae, Rhizoma Coptidis 5 parts, Radix Scutellariae 1 part, Cortex Phellodendri 6 parts, Flos Lonicerae 3 parts, Herba Andrographis 8 parts, Fructus Forsythiae 8 parts.
The present invention also provides the method for the Chinese medicine composition of preparation above-mentioned clinical care treatment diaper dermatitis, after Chinese medicine is pressurizeed, liquid level did not have 2-3cm, soak time 30 ~ 60 minutes, first decoct boil after 10 ~ 15 minutes, by juice slag be separated, slag carries out the second decoction, second decoct boil after 5 ~ 10 minutes, juice slag be separated after merge twice decoction liquor.
Using method of the present invention is, external, and every day wipes twice affected part.
In the present invention, Herba Portulacae heat-clearing and toxic substances removing, cooling blood for hemostasis, dysentery relieving.Radix Arnebiae (Radix Lithospermi) removing heat from blood, invigorates blood circulation, heat clearing away, removing toxic substances.Control warm macule, jaundice due to damp-heat, purpura, tell, be defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.The effects such as Indigo Naturalis nature and flavor are salty-cold, have heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, pathogenic fire purging arresting convulsion.It is mainly used in epidemic febrile disease intenseness of heat, macule, and spit blood, spit blood, pharyngalgia aphtha, pediatric epilepsy scared, skin ulcer swells, erysipelas, snake bite and insect sting etc.Borneolum Syntheticum can be used for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, to swell and ache for skin infection, do not hold back after bursting.Herba Houttuyniae is cold, returns lung meridian.Energy heat-clearing and toxic substances removing, detumescence treat skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, invigorating the stomach and promoting digestion, for controlling excess-heat, pyretic toxicity, damp, disease hot lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. for trouble.Herba Taraxaci nature and flavor are sweet, micro-hardship, cold.Return liver, stomach warp.There are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Control pyretic toxicity, carbuncle, skin infection, abscess of internal organ, conjunctival congestion and swelling pain, damp and hot, the puckery pain of jaundice, dribbling urination, furuncle swelling toxin, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection etc.Flos Chrysanthemi Indici cold nature, tool dispelling wind and heat pathogens, subduing swelling and detoxicating.Furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis can be treated, the disease such as dizzy of having a headache.The heat clearing away of chrysanthemum powder forimproving wind, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing.Folium Nelumbinis cures mainly summer-heat excessive thirst, pediatric epilepsy scared, and the inverse stupor of married woman's blood, gets injured by a fall hematemesis, menoxenia, metrorrhagia, eczema scabies.Spica Prunellae clearing away heat-fire, improving eyesight, mass dissipating and swelling eliminating.Folium Mori dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, cooling blood for hemostasis.Flos Sophorae cooling blood for hemostasis, purging liver-fire.Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication.Radix Scutellariae bitter in the mouth, cold in nature, there are heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.Cortex Phellodendri heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain.Herba Andrographis heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain.Fructus Forsythiae heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Radix Glycyrrhizae, QI invigorating invigorating middle warmer, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1:
A Chinese medicine composition for clinical care treatment diaper dermatitis, is made up of the raw material of following weight portion:
Herba Portulacae 10 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Indigo Naturalis 2 parts, Borneolum Syntheticum 7 parts, 2 parts, Radix Glycyrrhizae, Herba Houttuyniae 3 parts, Herba Taraxaci 5 parts, Flos Chrysanthemi Indici 5 parts, Flos Chrysanthemi 3 parts, 8 parts, Folium Nelumbinis, Spica Prunellae 3 parts, 2 parts, Folium Mori, 8 parts, Flos Sophorae, Rhizoma Coptidis 2 parts, Radix Scutellariae 5 parts, Cortex Phellodendri 2 parts, Flos Lonicerae 5 parts, Herba Andrographis 2 parts, Fructus Forsythiae 5 parts.
By Chinese medicine pressurize after, liquid level did not have 2-3cm, soak time 30 ~ 60 minutes, first decoct boil after 10 ~ 15 minutes, by juice slag be separated, slag carries out the second decoction, second decoct boil after 5 ~ 10 minutes, juice slag be separated after merge twice decoction liquor.
Embodiment 2:
A Chinese medicine composition for clinical care treatment diaper dermatitis, is made up of the raw material of following weight portion:
Herba Portulacae 5 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Indigo Naturalis 5 parts, Borneolum Syntheticum 5 parts, 5 parts, Radix Glycyrrhizae, Herba Houttuyniae 6 parts, Herba Taraxaci 1 part, Flos Chrysanthemi Indici 2 parts, Flos Chrysanthemi 6 parts, 2 parts, Folium Nelumbinis, Spica Prunellae 9 parts, 5 parts, Folium Mori, 3 parts, Flos Sophorae, Rhizoma Coptidis 5 parts, Radix Scutellariae 1 part, Cortex Phellodendri 6 parts, Flos Lonicerae 3 parts, Herba Andrographis 8 parts, Fructus Forsythiae 8 parts.
By Chinese medicine pressurize after, liquid level did not have 2-3cm, soak time 30 ~ 60 minutes, first decoct boil after 10 ~ 15 minutes, by juice slag be separated, slag carries out the second decoction, second decoct boil after 5 ~ 10 minutes, juice slag be separated after merge twice decoction liquor.
Medicinal liquid embodiment 1 prepared has carried out clinical trial, specific as follows:
Clinical data
1. diagnostic criteria
With reference to " Chinese medical disease Standardization of diagnosis and curative effect ".And be divided into gently by skin lesion, in, severe.Slight: diaper area dermathemia, swelling; Moderate: diaper area dermathemia, swelling, erosion, to ooze out; Severe: diaper area dermathemia, swelling, erosion, to ooze out, and secondary infection has pustule and ulcer.
2. physical data
Man 25 example in 84 examples, female 59 example; Age is neonate 21 example, and be less than example in March 46, the 3-6 month 17 is routine.28 examples that skin lesion is slight, moderate 52 example, severe 4 example.
3. therapeutic outcome
3.1 criterion of therapeutical effect
Slight infant is in medication after 2 days, and skin lesion disappears as recovery from illness, alleviates as effectively, unchanged or increase the weight of as invalid.Moderate infant after medication 4-7 days, skin without hyperemia, swelling, erosion, ooze out for recovery from illness, without swelling, erosion, ooze out, still redness is effective, and it is invalid that skin lesion is not kept to.Severe infant skin abscess after medication 7-9 days disappears, ulcer healing, and red and swollen disappearance is recovery from illness, and still redness is that effectively skin lesion is unchanged is invalid.
3.2 therapeutic outcome
Slight infant recovery from illness 28 example, moderate infant recovery from illness 50 example, effective 2 examples, severe infant recovery from illness 3 example, effective 1 example.

Claims (4)

1. a clinical care Chinese medicine composition for treatment diaper dermatitis, is made up of the raw material of following weight portion:
Herba Portulacae 5-10 part, Radix Arnebiae (Radix Lithospermi) 3-5 part, Indigo Naturalis 2-5 part, Borneolum Syntheticum 5-7 part, Radix Glycyrrhizae 2-5 part, Herba Houttuyniae 3-6 part, Herba Taraxaci 1-5 part, Flos Chrysanthemi Indici 2-5 part, Flos Chrysanthemi 3-6 part, Folium Nelumbinis 2-8 part, Spica Prunellae 3-9 part, Folium Mori 2-5 part, Flos Sophorae 3-8 part, Rhizoma Coptidis 2-5 part, Radix Scutellariae 1-5 part, Cortex Phellodendri 2-6 part, Flos Lonicerae 3-5 part, Herba Andrographis 2-8 part, Fructus Forsythiae 5-8 part.
2. the Chinese medicine composition of a kind of clinical care treatment diaper dermatitis as claimed in claim 1, is made up of the raw material of following weight portion:
Herba Portulacae 10 parts, Radix Arnebiae (Radix Lithospermi) 3 parts, Indigo Naturalis 2 parts, Borneolum Syntheticum 7 parts, 2 parts, Radix Glycyrrhizae, Herba Houttuyniae 3 parts, Herba Taraxaci 5 parts, Flos Chrysanthemi Indici 5 parts, Flos Chrysanthemi 3 parts, 8 parts, Folium Nelumbinis, Spica Prunellae 3 parts, 2 parts, Folium Mori, 8 parts, Flos Sophorae, Rhizoma Coptidis 2 parts, Radix Scutellariae 5 parts, Cortex Phellodendri 2 parts, Flos Lonicerae 5 parts, Herba Andrographis 2 parts, Fructus Forsythiae 5 parts.
3. the Chinese medicine composition of a kind of clinical care treatment diaper dermatitis as claimed in claim 1, is made up of the raw material of following weight portion:
Herba Portulacae 5 parts, Radix Arnebiae (Radix Lithospermi) 5 parts, Indigo Naturalis 5 parts, Borneolum Syntheticum 5 parts, 5 parts, Radix Glycyrrhizae, Herba Houttuyniae 6 parts, Herba Taraxaci 1 part, Flos Chrysanthemi Indici 2 parts, Flos Chrysanthemi 6 parts, 2 parts, Folium Nelumbinis, Spica Prunellae 9 parts, 5 parts, Folium Mori, 3 parts, Flos Sophorae, Rhizoma Coptidis 5 parts, Radix Scutellariae 1 part, Cortex Phellodendri 6 parts, Flos Lonicerae 3 parts, Herba Andrographis 8 parts, Fructus Forsythiae 8 parts.
4. the method for the Chinese medicine composition of diaper dermatitis is treated in preparation described a kind of clinical care as arbitrary in claim 1-3, it is characterized in that:
By Chinese medicine pressurize after, liquid level did not have 2-3cm, soak time 30 ~ 60 minutes, first decoct boil after 10 ~ 15 minutes, by juice slag be separated, slag carries out the second decoction, second decoct boil after 5 ~ 10 minutes, juice slag be separated after merge twice decoction liquor.
CN201510975256.9A 2015-12-22 2015-12-22 Traditional Chinese medicine composition used for treating diaper dermatitis and applied to clinical care as well as preparation method Pending CN105497244A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107789662A (en) * 2017-11-15 2018-03-13 济南毕昇信息科技有限公司 A kind of diaper and preparation method thereof
CN108096388A (en) * 2016-11-24 2018-06-01 林荣花 A kind of Chinese medicinal formulae for treating baby napkin dermatitis
CN108653792A (en) * 2018-05-29 2018-10-16 奇力护理用品（福建）有限公司 A kind of anti-diaper dermatitis paper diaper core face layer and preparation method thereof
CN108926734A (en) * 2018-08-02 2018-12-04 山东威高集团医用高分子制品股份有限公司 It is a kind of for treating the paper diaper of diaper rash
CN110101842A (en) * 2019-06-03 2019-08-09 李传峰 The Chinese medicine composition and its preparation method and application for treating neonate diaper dermatitis

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108096388A (en) * 2016-11-24 2018-06-01 林荣花 A kind of Chinese medicinal formulae for treating baby napkin dermatitis
CN107789662A (en) * 2017-11-15 2018-03-13 济南毕昇信息科技有限公司 A kind of diaper and preparation method thereof
CN108653792A (en) * 2018-05-29 2018-10-16 奇力护理用品（福建）有限公司 A kind of anti-diaper dermatitis paper diaper core face layer and preparation method thereof
CN108926734A (en) * 2018-08-02 2018-12-04 山东威高集团医用高分子制品股份有限公司 It is a kind of for treating the paper diaper of diaper rash
CN110101842A (en) * 2019-06-03 2019-08-09 李传峰 The Chinese medicine composition and its preparation method and application for treating neonate diaper dermatitis

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