CN100446784C - Chinese medicine for colitis and its preparation process - Google Patents
Chinese medicine for colitis and its preparation process Download PDFInfo
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- CN100446784C CN100446784C CNB2005100756306A CN200510075630A CN100446784C CN 100446784 C CN100446784 C CN 100446784C CN B2005100756306 A CNB2005100756306 A CN B2005100756306A CN 200510075630 A CN200510075630 A CN 200510075630A CN 100446784 C CN100446784 C CN 100446784C
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- radix arnebiae
- radix lithospermi
- herba sophorae
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Abstract
The present invention relates to Chinese medicine for colitis and a preparation process thereof, particularly to the Chinese medicine suitable for ulcerative colitis and the preparation process thereof. The present invention is composed of the following parts by weight of components: 1000 to 3000 of foxtaillike sophora, and 500 to 2000 of lithospermum. Indicated by a clinical test result, the total effective rate of the Chinese medicine to the ulcerative colitis is 70%; during a therapeutic period, obvious adverse reactions are not generated.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation technology thereof, this Chinese medicine has heat clearing and damp drying, the effect of detoxifcation dysentery relieving, be used for colitis, the retention of damp-heat in the interior of ulcerative colitis particularly, disease is seen diarrhoea, just defecation with blood and pus, stomachache pain in the abdomen, burning sensation of the anus, yellowish urine, yellow and greasy fur etc.
Background technology
Ulcerative colitis (being called for short the knot of bursting) is that a kind of agnogenic chronic colitis sexually transmitted disease (STD) becomes, and mainly is limited to the mucosa of colon, becomes the master with Peptic Ulcers.Involve rectum and sigmoid colon more, also can spread all over whole colon.Mainly showing as stomachache, diarrhoea, bloody purulent stool or mucosanguineous feces, is to be a kind of digestive tract disease of pathological characteristic with mucous membrane of colon chronic inflammatory disease and ulcer.The course of disease is chronic process, several years several years to ten or many decades, and often having shows effect repeatedly or continue increases the weight of, and idol has acute fulminant process.The inducement spiritedness stimulates, overworked, drinking and eating irregularly and secondary infection etc.In recent years because the improving constantly of living standard, the change of dietary structure, living habit, its sickness rate presents ascendant trend year by year.
Routed knot can be sent out in any age, with 20-50 year for seeing more.Now thinking bursts more ties is a kind of autoimmune disease, also may be relevant unusually with cellular immunization.Other reason also has factors such as anaphylaxis, infection, heredity.Burst and tie acute fulminant form's mortality rate height, the easy canceration of chronic lasting type.Stadium more than 5 years person's canceration rate be 17%.The foreign statistic data shows that 10 years person's canceration rates of patient's course of disease reach that the person can reach 40% more than 20%, 25 year.Particularly the course of disease is long, extent of disease is wide, the age, routed knot was acknowledged as the precancerous lesion of colon cancer than the lighter, how promptly to shift in early days, was classified as difficult and complicated illness by World Health Organization (WHO).
Elaboration to this disease etiology and pathogenesis in recent years mainly contains cytokine network dysfunction theory, apoptosis theory, the hungry theory of colonic epithelium metabolism, trace element deficiency theory, flora theory of infection etc.
Routed knot belongs to traditional Chinese medical science “ Chang Repair-in ", sick category such as " hemorrhoidal hamorrhage ", " dysentery ", " dysentery ".The traditional Chinese medical science is thought, the six hollow viscera must keep its unobstructed is suitable to reduce to.If the daily life imbalance, damp and hot pathogenic wind toxic is taken advantage of and is attacked, or has a liking for the pungent greasy product of food, and taste are impaired, damp and hot interior wine.The damp and hot pathogenic wind toxic large intestine of making a bet pents up and does not go, and gastrointestinal internal organs gas is unfavorable, and coagulation of QI-blood injures the intestinal network, accumulates and is pus, so see diarrhoea, just defecation with blood and pus, stomachache pain in the abdomen, burning sensation of the anus, yellowish urine, yellow and greasy fur etc.The traditional Chinese medical science thinks that dys-splenism is this sick key link, is also noted that the utilization drug for invigorating blood circulation and eliminating stasis, and suppository and enema therapy are effective local treatments; The mechanism of the routed knot of Chinese traditional treatment mainly is to adjust aspects such as immunity, protection intestinal mucosa, adjustment anal orifice and rectal intestine kinetics." treatment of disease must aim at its pathogenesis " controls suitable heat clearing and damp drying, the detoxifcation dysentery relieving, and damp eliminating hot blast poison, then gastrointestinal lead to and is fallen, and all diseases are when healing.
At present, the Drug therapy of the knot of bursting is based on sulfasalazine, corticosteroid, and immunosuppressant and anti-inflammatory agent also have certain curative effect, but these chemicals toxic and side effects are big, and effect is undesirable.
Sulfasalazine is the most frequently used medicine of the routed knot of treatment at present, be applicable to light, moderate or chronic phase patient, be generally oral, after 3g/d is oral, it does not absorb in the intestinal major part, and being metabolized to sulfapyridine and 5-aminosalicylic acid by Enterobacter cloaca, the latter can be by disturbing the synthetic therapeutical effect of bringing into play the knot of bursting of inflammation mediator prostaglandin.But the curative effect of this medicine and untoward reaction are directly proportional with consumption, and in the 4g/d that takes medicine, effective percentage is not as good as 50%, and the patient that 10%-15% is arranged approximately is because of the adverse effect drug withdrawal; Take medicine when surpassing the above dosage of 4g/d, improvement rate improves, the relapse rate reduction, but rate of adverse reactions can reach 37.5%.
The knot sickness rate raises year by year in view of bursting, course of disease length and delay are difficult to radical cure, the canceration rate height repeatedly, adverse reaction rate height, the patient of existing medicine is difficult to after tolerance and the drug withdrawal problems such as relapse rate height, and seeking safely and efficiently, medicine seems very urgent.
We follow the theoretical system that Chinese traditional treatment is burst and tied, and detect and combine with modern medical diagnosis technology, pathomorphology typing, laboratory, seek Chinese medicine new, that effective treatment is burst and tied.
Not retrieving in the prior art has good therapeutic effect and the low medicine of toxic and side effects to colitis especially ulcerative colitis.
Summary of the invention
The object of the present invention is to provide and a kind of above-mentioned colitis is treated Chinese medicine and preparation technology thereof safely and effectively.
For achieving the above object, the present invention adopts following technical scheme: it is made up of the component of following parts by weight:
Herba Sophorae alopecuroidis 1000～3000 Radix Arnebiae (Radix Lithospermi)s 500～2000
The preparation technology of Chinese medicine of the present invention is: Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, with percolation after the alcohol dipping, collects percolate, reclaim ethanol, be condensed into pure extractum, add appropriate amount of auxiliary materials, drying gets the dried cream of Radix Arnebiae (Radix Lithospermi) ethanol extract; Medicinal residues decoct with water 1～2 hour, filter, and filtrate is concentrated, dry, get the dried cream of Radix Arnebiae (Radix Lithospermi) water extract.Get Herba Sophorae alopecuroidis, decoct with water 2 times, each 1～2 hour, merge 2 times decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.25 (60 ℃), adds ethanol and makes that to contain the alcohol amount in the medicinal liquid be 50%～80%, stirs evenly, and leaves standstill; Get supernatant, reclaim ethanol, concentrated, dry, get the dried cream of Herba Sophorae alopecuroidis extract.With Radix Arnebiae (Radix Lithospermi) alcohol extract and dried cream of water extract and the dried cream merging of Herba Sophorae alopecuroidis extract, pulverize, add appropriate amount of auxiliary materials, adopt common process, make capsule, granule, tablet, dispersible tablet, buccal tablet, effervescent tablet, pill, solution and syrup etc.
Herba Sophorae alopecuroidis is a monarch drug in the side.The Herba Sophorae alopecuroidis bitter in the mouth, cold in nature, have bowel relieving dampness, pain-relieving functions cures mainly hygropyretic dysentery, and enteritis is had loose bowels etc." Inner Mongol Chinese herbal medicine " cloud: Herba Sophorae alopecuroidis " heat-clearing and toxic substances removing ".Cure mainly the etiology and pathogenesis of retention of damp-heat in the interior at it, the side with the Herba Sophorae alopecuroidis clearing away heat-damp and expelling toxic material with dispel its because of, and have pain relieving in order to alleviate the primary symptom of stomachache, be to be monarch drug.
The side is a ministerial drug with the Radix Arnebiae (Radix Lithospermi).Radix Arnebiae (Radix Lithospermi), nature and flavor are sweet, salty, and are cold.GUIXIN, Liver Channel.The function removing heat from blood, invigorate blood circulation the detoxifcation rash.Be used for the heat in blood poison and contain, macule is purple black, measles without adequate eruption, skin infection, eczema, jaundice, epistaxis, hematuria etc." detailed outline " cloud: Radix Arnebiae (Radix Lithospermi) " promoting blood circulation and cooling blood, sharp large intestine." " traditional Chinese medicines are annotated card " cloud: " Radix Arnebiae (Radix Lithospermi), nature and flavor bitter cold, bitter energy dampness, the heat clearing away of cold energy." " book on Chinese herbal medicine justice " cloud: " and Radix Arnebiae (Radix Lithospermi), the abnormal smells from the patient bitter cold, and the color purple is gone into blood, so the heat of cleaning blood system is ancient to control the accumulation of heat of internal organs, the then special treatment of smallpox infections of descendant is treated macule, all positive purport of heat clearing and blood cooling and hold concurrently." the square merit that can strengthen monarch drug with the heat-clearing and toxic substances removing dampness of Radix Arnebiae (Radix Lithospermi).Answer with its removing heat from blood, invigorate blood circulation, stop blooding, the tonneau large intestine helps the just improvement of disease such as defecation with blood and pus, tenesmus.
Herba Sophorae alopecuroidis, Radix Arnebiae (Radix Lithospermi) two medicine compatibilities, with playing heat clearing and damp drying, the merit of detoxifcation dysentery relieving is coincide with the cure mainly knot retention of damp-heat in the interior card etiology and pathogenesis of bursting.And disease disease is taken into account, and square Jian Lihong is characteristic.
Pharmacological experiments shows, contains multiple alkaloid and a small amount of flavones ingredients such as matrine, oxymatrine, sophoridine, sophocarpine, sophoramine in the Herba Sophorae alopecuroidis; Contain multiple naphthoquinone pigment and furans compositions such as Acetyl-shikonin Acetylshikonin, shikonin in the Radix Arnebiae (Radix Lithospermi).Resisting pathogenic microbes effect and antiinflammatory and immunosuppressive actions such as that the extract of Herba Sophorae alopecuroidis and Radix Arnebiae (Radix Lithospermi) has is significantly antibiotic, antiviral; alimentary canal inflammation and ulcer had the good curing effect; especially the reparation to ulcer surface has definite pharmacological action, the effect that also has the liver protecting, shrinks digestive system effect such as intestinal smooth muscle and improve the loose stool symptom and repair mucosa injury.
Pharmacodynamic study is the result show, Chinese medicine of the present invention can obviously improve inductive colitis companion's ulcer of TNBS and pathological lesion, by the inhibited oxidation radical reaction, significantly strengthens the histiocyte oxidation resistance, significantly alleviate the mucous membrane of colon inflammation, significantly promote ulcer healing.
Clinical research is the result show, Chinese medicine of the present invention is 10% to the obvious effective rate of the knot of bursting, and effective percentage is 60%, and total effective rate is 70%, and therapeutic process is not seen obvious adverse reaction.
The specific embodiment
Embodiment 1
Get Herba Sophorae alopecuroidis 2100g, Radix Arnebiae (Radix Lithospermi) 1050g.Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, with percolation after the alcohol dipping, collects percolate, reclaim ethanol, be condensed into pure extractum, add appropriate amount of auxiliary materials, drying gets the dried cream of Radix Arnebiae (Radix Lithospermi) ethanol extract; Medicinal residues decoct with water 1～2 hour, filter, and filtrate is concentrated, dry, get the dried cream of Radix Arnebiae (Radix Lithospermi) water extract.Get Herba Sophorae alopecuroidis, decoct with water 2 times, each 1～2 hour, merge 2 times decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.25 (60 ℃), adds ethanol and makes that to contain the alcohol amount in the medicinal liquid be 50%～80%, stirs evenly, and leaves standstill; Get supernatant, reclaim ethanol, concentrated, dry, get the dried cream of Herba Sophorae alopecuroidis extract.With Radix Arnebiae (Radix Lithospermi) alcohol extract and dried cream of water extract and the dried cream merging of Herba Sophorae alopecuroidis extract, pulverize, add appropriate amount of auxiliary materials, granulation, dry, granulate, 1000 capsules are made in the fill of employing common process.
Embodiment 2
Get Herba Sophorae alopecuroidis 1000g, Radix Arnebiae (Radix Lithospermi) 500g.Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, with percolation after the alcohol dipping, collects percolate, reclaim ethanol, be condensed into pure extractum, add appropriate amount of auxiliary materials, drying gets the dried cream of Radix Arnebiae (Radix Lithospermi) ethanol extract; Medicinal residues decoct with water 1～2 hour, filter, and filtrate is concentrated, dry, get the dried cream of Radix Arnebiae (Radix Lithospermi) water extract.Get Herba Sophorae alopecuroidis, decoct with water 2 times, each 1～2 hour, merge 2 times decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.25 (60 ℃), adds ethanol and makes that to contain the alcohol amount in the medicinal liquid be 50%～80%, stirs evenly, and leaves standstill; Get supernatant, reclaim ethanol, concentrated, dry, get the dried cream of Herba Sophorae alopecuroidis extract.With Radix Arnebiae (Radix Lithospermi) alcohol extract and dried cream of water extract and the dried cream merging of Herba Sophorae alopecuroidis extract, pulverize, add appropriate amount of auxiliary materials, granulation, drying adopt common process to be distributed into 1000 bags of granules.
Embodiment 3
Get Herba Sophorae alopecuroidis 1500g, Radix Arnebiae (Radix Lithospermi) 800g.Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, with percolation after the alcohol dipping, collects percolate, reclaim ethanol, be condensed into pure extractum, add appropriate amount of auxiliary materials, drying gets the dried cream of Radix Arnebiae (Radix Lithospermi) ethanol extract; Medicinal residues decoct with water 1～2 hour, filter, and filtrate is concentrated, dry, get the dried cream of Radix Arnebiae (Radix Lithospermi) water extract.Get Herba Sophorae alopecuroidis, decoct with water 2 times, each 1～2 hour, merge 2 times decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.25 (60 ℃), adds ethanol and makes that to contain the alcohol amount in the medicinal liquid be 50%～80%, stirs evenly, and leaves standstill; Get supernatant, reclaim ethanol, concentrated, dry, get the dried cream of Herba Sophorae alopecuroidis extract.With Radix Arnebiae (Radix Lithospermi) alcohol extract and dried cream of water extract and the dried cream merging of Herba Sophorae alopecuroidis extract, pulverize, add appropriate amount of auxiliary materials, granulation, drying adopt the common process tabletting, make 1000 tablets of tablets.
Embodiment 4
Get Herba Sophorae alopecuroidis 1800g, Radix Arnebiae (Radix Lithospermi) 1300g.Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, with percolation after the alcohol dipping, collects percolate, reclaim ethanol, be condensed into pure extractum, add appropriate amount of auxiliary materials, drying gets the dried cream of Radix Arnebiae (Radix Lithospermi) ethanol extract; Medicinal residues decoct with water 1～2 hour, filter, and filtrate is concentrated, dry, get the dried cream of Radix Arnebiae (Radix Lithospermi) water extract.Get Herba Sophorae alopecuroidis, decoct with water 2 times, each 1～2 hour, merge 2 times decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.25 (60 ℃), adds ethanol and makes that to contain the alcohol amount in the medicinal liquid be 50%～80%, stirs evenly, and leaves standstill; Get supernatant, reclaim ethanol, concentrated, dry, get the dried cream of Herba Sophorae alopecuroidis extract.With Radix Arnebiae (Radix Lithospermi) alcohol extract and dried cream of water extract and the dried cream merging of Herba Sophorae alopecuroidis extract, pulverize, add appropriate amount of auxiliary materials, adopt common process to make pill.
Embodiment 5
Get Herba Sophorae alopecuroidis 2100g, Radix Arnebiae (Radix Lithospermi) 1050g.Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, with percolation after the alcohol dipping, collects percolate, reclaim ethanol, be condensed into pure extractum, add appropriate amount of auxiliary materials, drying gets the dried cream of Radix Arnebiae (Radix Lithospermi) ethanol extract; Medicinal residues decoct with water 1～2 hour, filter, and filtrate is concentrated, dry, get the dried cream of Radix Arnebiae (Radix Lithospermi) water extract.Get Herba Sophorae alopecuroidis, decoct with water 2 times, each 1～2 hour, merge 2 times decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.25 (60 ℃), adds ethanol and makes that to contain the alcohol amount in the medicinal liquid be 50%～80%, stirs evenly, and leaves standstill; Get supernatant, reclaim ethanol, concentrated, dry, get the dried cream of Herba Sophorae alopecuroidis extract.With Radix Arnebiae (Radix Lithospermi) alcohol extract and dried cream of water extract and the dried cream merging of Herba Sophorae alopecuroidis extract, pulverize, add appropriate amount of auxiliary materials, adopt the common process fill, make 1000 solutions.
Embodiment 6
Get Herba Sophorae alopecuroidis 3000g, Radix Arnebiae (Radix Lithospermi) 2000g.Radix Arnebiae (Radix Lithospermi) is ground into coarse powder, with percolation after the alcohol dipping, collects percolate, reclaim ethanol, be condensed into pure extractum, add appropriate amount of auxiliary materials, drying gets the dried cream of Radix Arnebiae (Radix Lithospermi) ethanol extract; Medicinal residues decoct with water 1～2 hour, filter, and filtrate is concentrated, dry, get the dried cream of Radix Arnebiae (Radix Lithospermi) water extract.Get Herba Sophorae alopecuroidis, decoct with water 2 times, each 1～2 hour, merge 2 times decoction liquor, filter, filtrate is concentrated into the clear paste that relative density is 1.10～1.25 (60 ℃), adds ethanol and makes that to contain the alcohol amount in the medicinal liquid be 50%～80%, stirs evenly, and leaves standstill; Get supernatant, reclaim ethanol, concentrated, dry, get the dried cream of Herba Sophorae alopecuroidis extract.With Radix Arnebiae (Radix Lithospermi) alcohol extract and dried cream of water extract and the dried cream merging of Herba Sophorae alopecuroidis extract, pulverize, add right amount of auxiliary materials such as simple syrup, adopt the common process fill, make 1000 syrups.
Claims (1)
1. a Chinese medicine for the treatment of ulcerative colitis is characterized in that it is to get 1000～3000 weight portion Herba Sophorae alopecuroidiss, decocts with water 2 times, per 1～2 hour, merge 2 times decoction liquor, filter, measure relative density when filtrate is concentrated into 60 ℃ and be 1.10～1.25 clear paste, add ethanol and make that to contain the alcohol amount in the medicinal liquid be 50%～80%, stir evenly, leave standstill, get supernatant, reclaim ethanol, concentrate, drying gets the Herba Sophorae alopecuroidis extract dry extract; Get 500～2000 weight portion Radix Arnebiae (Radix Lithospermi)s, be ground into coarse powder, with percolation after the alcohol dipping, collect percolate, reclaim ethanol, be condensed into pure extractum, add appropriate amount of auxiliary materials, drying gets Radix Arnebiae (Radix Lithospermi) ethanol extraction dry extract; Get the medicinal residues of Radix Arnebiae (Radix Lithospermi) ethanol extraction, decoct with water 1～2 hour, filter, filtrate concentrates, and drying gets Radix Arnebiae (Radix Lithospermi) water extract dry extract; Get Herba Sophorae alopecuroidis extract dry extract and Radix Arnebiae (Radix Lithospermi) ethanol extraction and water extract dry extract and merge, pulverize, add appropriate amount of auxiliary materials, the capsule or granule or tablet or pill or solution or the syrup that adopt conventional formulation technology to make.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100756306A CN100446784C (en) | 2005-06-02 | 2005-06-02 | Chinese medicine for colitis and its preparation process |
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| CN100446784C true CN100446784C (en) | 2008-12-31 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102058676B (en) * | 2009-11-16 | 2013-05-08 | 甘肃中医学院 | Traditional Chinese medicinal extract for treating ulcerative colitis, medicinal composition thereof and preparation method thereof |
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2005
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Non-Patent Citations (4)
| Title |
|---|
| 国家中成药标准汇编-中成药地方标准上升国家标准部分-内科、脾胃分册. 138-141，国家药品监督管理局. 2002 |
| 国家中成药标准汇编-中成药地方标准上升国家标准部分-内科、脾胃分册. 138-141，国家药品监督管理局. 2002 * |
| 紫草在慢性胃炎及消化性溃疡病中的应用. 韩清，孔祥梅，桑雁.中医杂志，第37卷第7期. 1996 |
| 紫草在慢性胃炎及消化性溃疡病中的应用. 韩清，孔祥梅，桑雁. 中医杂志，第37卷第7期. 1996 * |
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