CN103142752A - Urinary calculus treatment medicine and its preparation method - Google Patents
Urinary calculus treatment medicine and its preparation method Download PDFInfo
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- CN103142752A CN103142752A CN2013100499405A CN201310049940A CN103142752A CN 103142752 A CN103142752 A CN 103142752A CN 2013100499405 A CN2013100499405 A CN 2013100499405A CN 201310049940 A CN201310049940 A CN 201310049940A CN 103142752 A CN103142752 A CN 103142752A
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Abstract
The invention discloses a urinary calculus treatment medicine and its preparation method. The urinary calculus treatment medicine is prepared through using Lysimachia christinae Hance, Spora Lygodii, chicken's gizzard-membrane, Cassia Twig, safflower, Spina Gleditsiae, Vaccaria segetalis and the like according to certain weight proportions. The urinary calculus treatment medicine has the functions of heat clearing, diuresis promoting, kidney tonifying, water moving, stranguria treating and calculus dissolving, and has the advantages of fast effectiveness, good curative effect and high cure rate when the medicine is used for treating urinary calculus.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of urinary system calculus and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Urinary system calculus betides urinary system, claims again urinary calculus.The calculus that comprises kidney, ureter, bladder and urethra.The sickness rate of urinary calculus has obvious regional difference, and many urinary calculis hotspots is arranged in the world, and the sickness rate of southern china is far above the north.The Guangdong sickness rate really belongs to exception up to 3.6 ‰.Genesis and the nutriture of urinary calculus have substantial connection, take vegetable protein as main, lack phosphate in urine in poor and backward national food, and vesical calculus easily occurs, and children's is particularly common, and developed country's common adult's calcic renal calculus.The theory that urinary calculi forms is a lot, as becoming nuclear doctrine, theory of matrix initiation, crystallization mortifier theory, the formation mechanism of whole urinary calculis can be described without any theory also.The blocking of urinary system, foreign body and infection can promote urinary calculi to form, otherwise urinary calculi can be again the inducement of blocking, infecting.The Developmental and Metabolic Disorder such as metabolic disease such as hyperparathyroidism, gout, oxalic acid and cystine can be also the reasons that urinary calculi forms.Urinary system calculus brings great inconvenience to patient's daily life and work.At present, western medicine urinary system calculus poor effect, and more side effect is arranged, therefore, there is very large demand in people to the Chinese medicine of effective treatment urinary system calculus.
Summary of the invention
The inventor has finally found the medicine of effective treatment urinary system calculus, thereby has completed the present invention according to the research of theory of Chinese medical science and clinical repeatedly test and checking.
Purpose of the present invention just is to provide a kind of composition of medicine that can effectively treat urinary system calculus.
Another object of the present invention just has been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Ramulus Cinnamomi, Flos Carthami, Spina Gleditsiae, Semen Vaccariae, Radix Clematidis, the Radix Astragali, Radix Rehmanniae, Radix Codonopsis, Semen Plantaginis crude drug to make up, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of urinary system calculus.Wherein select Herba Lysimachiae to be because its nature and flavor toil is cool, heat clearing away is arranged, diuresis, antitussive, detumescence, the function of detoxifcation, the subcutaneous ulcer of harnessing the Yellow River, edema, vesical calculus, malaria, lung abscess, cough is spitted blood, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, infantile malnutrition ， Jing Epilepsy, carbuncle, skin ulcer tinea, eczema.Select Spora Lygodii to be because its property slightly sweet flavor is cold, enter small intestinal, urinary bladder channel, heat-clearing and toxic substances removing is arranged, the function of relieving stranguria by diuresis is controlled urinary tract infection, lithangiuria, nebulousurine, leucorrhea, hepatitis, oedema due to nephritis, laryngopharynx swelling and pain, mumps, enteritis, dysentery, skin eczema, herpes zoster.Select Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, control stagnantly, the function of strengthening the spleen and stomach is controlled the food stagnation distension, vomiting regurgitation, and dysentery, infantile malnutrition is quenched one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Selecting Ramulus Cinnamomi is that temperature enters bladder, the heart, lung meridian, and the diaphoresis expelling pathogenic factors from muscles is arranged because of its property acrid-sweet flavor, and the function of warming the meridian and promoting blood circulation is controlled exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen.Select Flos Carthami to be because its nature and flavor are hot, temperature enters the heart, Liver Channel, and promoting blood circulation to restore menstrual flow is arranged, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Spina Gleditsiae to be because its nature and flavor are hot, temperature is searched wind, draw out pus by applying a plaster to the affected part, and detumescence, the function of evacuation of pus is controlled carbuncle, sore, leprosy, tinea skin ulcer, placenta retention.Select Semen Vaccariae to be because its nature and flavor are bitter flat, enter liver, stomach warp, have promoting the circulation of blood to stimulate the menstrual flow, expedite the emergence of stimulating milk secretion, the function of detumescence sore is controlled women's amenorrhea, galactostasis, and difficult labour, stranguria with blood, carbuncle, incised wound is hemorrhage.Select Radix Clematidis to be because its nature and flavor suffering is salty, temperature, poisonous, enter urinary bladder channel, wind-damp dispelling is arranged, the meridian dredging, expectorant saliva, the function of the loose hypochondriac lump is controlled gout, insensitive impediment, chills and pain of the waist and kness, beriberi, malaria ， lumps in the chest and abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.Select the Radix Astragali to be because its nature and flavor are sweet, tepor enters lung, spleen channel, give birth to the useful consolidating superficial resistance of defending, and inducing diuresis to remove edema, poison holding, the function of granulation promoting is controlled spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and hold back for a long time; Process with the function that the invigorating middle warmer benefit is arranged, control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Rehmanniae to be because its nature and flavor are sweet, cold, GUIXIN, liver, kidney channel have clearing away heat and cooling blood, yin nourishing, and the function of promoting the production of body fluid is controlled the calentura excessive thirst, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, the meridian of Foot-TAI YIN edema caused by disorder of QI, invigorating the spleen and replenishing QI is arranged, the function of promoting the production of body fluid is controlled weakness of the spleen and stomach, deficiency of both QI and blood, and fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Select Semen Plantaginis to be because its nature and flavor are sweet, cold, enter kidney, urinary bladder channel, diuretic is arranged, heat clearing away makes eye bright, and the function of eliminating the phlegm is controlled urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, the heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view.
The drug dose of the present invention's combination is also that the inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect in the following weight scope
Herba Lysimachiae 25-35 gram Spora Lygodii 10-20 gram Endothelium Corneum Gigeriae Galli 10-20 grams
Ramulus Cinnamomi 1-5 gram Flos Carthami 1-5 gram Spina Gleditsiae 1-5 grams
Semen Vaccariae 6-15 gram Radix Clematidis 10-20 gram Radix Astragali 10-20 grams
Radix Rehmanniae 10-20 gram Radix Codonopsis 10-20 gram Semen Plantaginis 10-15 grams
Preferable amount is
Herba Lysimachiae 30 gram Spora Lygodii 15 gram Endothelium Corneum Gigeriae Galli 15 grams
Ramulus Cinnamomi 3 gram Flos Carthami 3 gram Spina Gleditsiae 3 grams
The Semen Vaccariae 9 gram Radix Clematidis 15 gram Radix Astragali 15 grams
Radix Rehmanniae 15 gram Radix Codonopsis 15 gram Semen Plantaginis 12 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Herba Lysimachiae: choose clean impurity, sieve dedust bits dry;
2, Spora Lygodii: get crude drug, cross dusting cover, sieve is got spore, removes impurity;
3, Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;
4, Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening is cut into slices to thoroughly, dries, and sieves anti-dandruff;
5, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
6, Spina Gleditsiae: choose decontamination, be soaked in water, run through rear section, dry;
7, Semen Vaccariae: the clean impurity of winnowing with a dustpan, put in pot, take out when spending six, seventy percent with the slow fire stir-fry in vain to popping, cool;
8, Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting is dried;
9, the Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
10, Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cut sheet, drying, and sieve removes chip;
11, Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;
12, Semen Plantaginis: choose decontamination, sieve removes spare, empty grain.
Two, preparation
1, Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Ramulus Cinnamomi, Flos Carthami, Spina Gleditsiae, Semen Vaccariae, Radix Clematidis, the Radix Astragali, Radix Rehmanniae, Radix Codonopsis, the Semen Plantaginis of described weight are put into the container of boiling medicine, add for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 10 minutes, filtered in 20 minutes with slow fire boiling, decoction liquor is poured in container for the first time again.
2, the medicinal residues that filter are added 2 times of amounts of water, first boil with very hot oven, then used slow fire boiling 15 minutes, decoction liquor is poured in container for the second time.
3, twice decoction liquor mixed the decoction boiling, then used slow fire boiling 10 minutes, be divided into 3 doses.
Medicine of the present invention has the function of Yishen Jianpi, clearing away heat-damp and promoting diuresis, the kidney invigorating row water, treating stranguria and eliminating stone, is used for the treatment of urinary system calculus, short treating period, instant effect, non-relapse after healing, has no side effect.
The specific embodiment
Below further set forth the beneficial effect of medicine of the present invention by test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.3kg divides two groups, and 15 every group, wherein one group is the overdose test group, and another group is the normal amount test group.The super quantity group is 30ml/kg, and normal amount is 10ml/kg, and administering mode is the administration by gavage administration, and every day, secondary, serve on 7 days, observes the administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation material of [test example 2] Drug therapy urinary system calculus of the present invention
1, physical data
Accept out-patient's totally 150 examples for medical treatment, male 118 examples wherein, female's 32 examples.
2, diagnostic criteria
Urinary system calculus claims again lithangiuria
Urinary calculus
Urinary system calculus
It is the Iithiasic general name in each position of urinary system
It is the commonly encountered diseases of urinary system
Difference according to position, calculus place
Be divided into renal calculus
Ureteral calculus
Vesical calculus
Calculus of urethra.The formation of primary disease and environmental factors
General pathological changes and diseases of urinary system have close inspection relation
The visible waist angina abdominis of its typical clinical Cardiac Manifestation
Hematuria
Or with frequent micturition
Urgent micturition
The clean symptom of the obstruction of urinary systems such as dysurea and infection
3, Therapeutic Method
Select above-mentioned medicament, take to the patient, each serving with 1 dose, every day early, middle and late respectively the clothes 1 time, 10 days is a course for the treatment of, takes continuously 4 courses for the treatment of.
4, efficacy assessment standard
Produce effects: calculus transference cure, body constitution recover normal, observe half a year without the recidivist;
Take a turn for the better: symptom is clearly better, and body constitution is progressively recovered;
Invalid: as not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, with Drug therapy urinary system calculus patient of the present invention 150 examples, produce effects 140 examples as a result, obvious effective rate is 93.33%, 6 examples that take a turn for the better, improvement rate is 4%, invalid 4 examples, total effective rate is 97.33%.
Claims (3)
1. medicine for the treatment of urinary system calculus, it is characterized in that: it is to be made by the crude drug in following weight range:
Herba Lysimachiae 25-35 gram Spora Lygodii 10-20 gram Endothelium Corneum Gigeriae Galli 10-20 grams
Ramulus Cinnamomi 1-5 gram Flos Carthami 1-5 gram Spina Gleditsiae 1-5 grams
Semen Vaccariae 6-15 gram Radix Clematidis 10-20 gram Radix Astragali 10-20 grams
Radix Rehmanniae 10-20 gram Radix Codonopsis 10-20 gram Semen Plantaginis 10-15 grams.
2. treat according to claim 1 the medicine of urinary system calculus, wherein the consumption of each crude drug is:
Herba Lysimachiae 30 gram Spora Lygodii 15 gram Endothelium Corneum Gigeriae Galli 15 grams
Ramulus Cinnamomi 3 gram Flos Carthami 3 gram Spina Gleditsiae 3 grams
The Semen Vaccariae 9 gram Radix Clematidis 15 gram Radix Astragali 15 grams
Radix Rehmanniae 15 gram Radix Codonopsis 15 gram Semen Plantaginis 12 grams.
3. the preparation method of described medicine according to claim 1 and 2, it comprises the following steps:
(1) get the raw materials ready
(1) Herba Lysimachiae: choose clean impurity, sieve dedust bits dry;
(2) Spora Lygodii: get crude drug, cross dusting cover, sieve is got spore, removes impurity;
(3) Endothelium Corneum Gigeriae Galli: choose decontamination, rinse and dry;
(4) Ramulus Cinnamomi: water slightly soaks, and pulls out, and moistening is cut into slices to thoroughly, dries, and sieves anti-dandruff;
(5) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;
(6) Spina Gleditsiae: choose decontamination, be soaked in water, run through rear section, dry;
(7) Semen Vaccariae: the clean impurity of winnowing with a dustpan, put in pot, take out when spending six, seventy percent with the slow fire stir-fry in vain to popping, cool;
(8) Radix Clematidis: choose clean impurity, remove residual stem, be soaked in water, pull out and run through, cutting is dried;
(9) Radix Astragali: choose clean impurity, remove residual root head and hollow the greater, be soaked in water, pull out, run through rear timely section, dry;
(10) Radix Rehmanniae: get crude drug, remove impurity, clean, slightly profit, cut sheet, drying, and sieve removes chip;
(11) Radix Codonopsis: run through reed after cleaning silt, section or cutting are dried;
(12) Semen Plantaginis: choose decontamination, sieve removes spare, empty grain;
(2) preparation
(1) Herba Lysimachiae, Spora Lygodii, Endothelium Corneum Gigeriae Galli, Ramulus Cinnamomi, Flos Carthami, Spina Gleditsiae, Semen Vaccariae, Radix Clematidis, the Radix Astragali, Radix Rehmanniae, Radix Codonopsis, the Semen Plantaginis of described weight are put into the container of boiling medicine, add for the first time 4 times of amounts of water, soak after 60 minutes, intense fire decocts boiling 10 minutes, filtered in 20 minutes with slow fire boiling, decoction liquor is poured in container for the first time again;
(2) medicinal residues that filter are added 2 times of amounts of water, first boil with very hot oven, then used slow fire boiling 15 minutes, decoction liquor is poured in container for the second time;
(3) twice decoction liquor mixed the decoction boiling, then used slow fire boiling 10 minutes, be divided into 3 doses.
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Cited By (3)
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| CN103585597A (en) * | 2013-10-18 | 2014-02-19 | 陈丙动 | Traditional Chinese medicine composition for relieving severe pain caused by renal calculus |
| CN105687375A (en) * | 2016-03-21 | 2016-06-22 | 刘琴兰 | Medicine for treating lithiasis in urinary system |
| CN108670990A (en) * | 2018-07-26 | 2018-10-19 | 李茂辉 | A kind of drug and preparation method thereof for treating calculi in urinary system |
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| CN108670990A (en) * | 2018-07-26 | 2018-10-19 | 李茂辉 | A kind of drug and preparation method thereof for treating calculi in urinary system |
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Application publication date: 20130612 |