CN107334990A - Chinese medicine preparation for uterus toxin expelling and its preparation method and application - Google Patents
Chinese medicine preparation for uterus toxin expelling and its preparation method and application Download PDFInfo
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- CN107334990A CN107334990A CN201710704821.7A CN201710704821A CN107334990A CN 107334990 A CN107334990 A CN 107334990A CN 201710704821 A CN201710704821 A CN 201710704821A CN 107334990 A CN107334990 A CN 107334990A
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Abstract
The invention provides Chinese medicine preparation for uterus toxin expelling and its preparation method and application.Chinese medicine preparation of the present invention passes through ginkgo leaf, field pennycress, Verbena officinalis, and the various ingredients such as kuh-seng are raw material, and pass through the compatibility effect of each component in raw material, uterus toxin expelling can be effectively facilitated, thoroughly cleaning uterus and reproductive system, have the effect of fine to vaginitis, adnexitis, pelvic infecton, cervical erosion, endometritis, fibroid, gynaecology's tumour, abnormal leucorrhea, itch etc.；Simultaneously, additionally it is possible to be effectively improved microcirculation, dispelling stain point, make the moist pale high resilience of skin；And further there is regulation menstruation, the effect of being effectively improved the symptoms such as menstrual period dysmenorrhoea, soreness and weakness of waist and knees, while vaginal relaxation can also be effectively improved.The present invention is used for the preparation method of the Chinese medicine preparation of uterus toxin expelling, has step simple, easy to operate, the advantages that preparation suitable for industrial-scale production.
Description
Technical field
The present invention relates to field of traditional Chinese, in particular to the Chinese medicine preparation for uterus toxin expelling and its preparation side
Method and application.
Background technology
The disease of the reproductive system of women is referred to as gynaecological disease, and disease is a lot, is women common disease, and the incidence of disease accounts for reproduction age
The 60% of women, Child-bearing Aged Women in Countryside is even up to 80%.If treatment is not thorough, very easily recurrence, serious is tired
The health of women, the also problems such as family life are disturbed, such as not treated as soon as possible, it is also possible to deterioration causes serious consequence, and
Chronic cervicitis, cervical erosion can trigger cervical carcinoma to be built consensus in medical field, thus, active prevention and treatment gynaecology disease
Disease has great importance.
At present, gynaecological disease is mainly treated using Western medicine, but obvious the defects of Western medicine, for example, act on it is single,
The resistance to the action of a drug is also easy to produce, and many external application Western medicine have excitant, are easy to trigger allergy, while externally applied drug having for intravaginal
Bacteria group equally has killing action, easily causes intravaginal flora imbalance, destroys the self-cleaning system of vagina on the contrary；And medical instrument for oral administration
There is larger side effect, stimulating intestine and stomach is larger simultaneously for the pressure of kidney, and is unsuitable for pregnant woman and women breast-feeding their children's use.
Thus, a kind of external used medicine that can be had no toxic side effect and can effectively cure gynaecological disease is developed, has become mesh
Preceding technical problem urgently to be resolved hurrily.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of Chinese medicine preparation for uterus toxin expelling, and the Chinese medicine preparation passes through silver
Apricot leaf, field pennycress, Verbena officinalis, and the various ingredients such as kuh-seng are raw material, pass through the compatibility effect of each component in raw material, Neng Gouyou
Effect promotes uterus toxin expelling, uterus and reproductive system is thoroughly cleaned, so as to realize effective treatment for gynecological disease.
The second object of the present invention is to provide a kind of preparation method of the described Chinese medicine preparation for uterus toxin expelling, is somebody's turn to do
Method has preparation method step simple, the advantages that preparation suitable for industrial-scale production.
The third object of the present invention is to provide a kind of application of the described Chinese medicine preparation for uterus toxin expelling.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme：
A kind of Chinese medicine preparation for uterus toxin expelling, the Chinese medicine preparation for uterus toxin expelling is mainly by following components system
Into：Ginkgo leaf, field pennycress, Verbena officinalis, kuh-seng, the bark of the root or stem of the tree of heaven, frutus cnidii, the tuber of stemona, rhizoma atractylodis, blood scorpion, safflower, peppermint grass, and
Chinese gall.
Preferably, in parts by weight, the Chinese medicine preparation of the present invention for uterus toxin expelling is mainly by following components
It is made：15~25 parts of ginkgo leaf, 15~25 parts of field pennycress, 15~25 parts of Verbena officinalis, 5~10 parts of kuh-seng, 5~10 points of the bark of the root or stem of the tree of heaven,
3~10 parts of frutus cnidii, 3~10 parts of the tuber of stemona, 5~12 parts of rhizoma atractylodis, 5~12 parts of blood scorpion, 5~12 parts of safflower, peppermint grass 10~20
Part, and 5~12 parts of Chinese gall.
Preferably, in parts by weight, the Chinese medicine preparation of the present invention for uterus toxin expelling is mainly by following components
It is made：18~20 parts of ginkgo leaf, 18~20 parts of field pennycress, 18~20 parts of Verbena officinalis, 6~8 parts of kuh-seng, 6~8 points of the bark of the root or stem of the tree of heaven, snake
5~8 parts of machine tool, 5~8 parts of the tuber of stemona, 8~10 parts of rhizoma atractylodis, 8~10 parts of blood scorpion, 8~10 parts of safflower, 15~18 parts of peppermint grass, with
And 8~10 parts of Chinese gall.
Meanwhile present invention also offers the preparation method of the Chinese medicine preparation for uterus toxin expelling, comprise the following steps：
By each component heating extraction in the present invention, and distill, dry after gained extract solution is concentrated, obtain solids extraction thing, flashing is
Ball, as described Chinese medicine preparation.
Preferably, in the preparation method of the Chinese medicine preparation of the present invention for uterus toxin expelling, be first by each component with
After Extraction solvent infiltration, add Extraction solvent and carry out heating extraction；It is furthermore preferred that the time of the infiltration is 3~6h.
Preferably, in the preparation method of the Chinese medicine preparation of the present invention for uterus toxin expelling, the Extraction solvent includes
75~85% ethanol；And/or 4~6 times that the quality of Extraction solvent used in heating extraction is each component gross mass.
Preferably, in the preparation method of the Chinese medicine preparation of the present invention for uterus toxin expelling, the heating extraction is carrying
Take in tank and carry out, and extract solution is discharged after extraction solution temperature reaches 70~100 DEG C, while new extraction is supplemented into extractor
Solvent.
Preferably, in the preparation method of the Chinese medicine preparation of the present invention for uterus toxin expelling, the concentration is dense to evaporate
The step of contracting, and further comprising recycling recycling of condensed steam；And/or the distillation is vacuum distillation.
Further, present invention also offers the Chinese medicine preparation for uterus toxin expelling to prepare removing vagina and uterus
Application in metabolite and toxin pharmaceutical；And/or preparing the application in adjusting menstruation medicine；And/or improve preparing
Application in vaginal relaxation medicine.
To prepare improvement microcirculation likewise, present invention provides the Chinese medicine preparation for uterus toxin expelling, go
Except the application in color spot medicine.
Compared with prior art, beneficial effects of the present invention are：
(1) Chinese medicine preparation raw material of the present invention is natural herbal, for Western medicine, for the toxic side effect of human body
It is small, and the autoimmunity and uterus detoxification ability of human body can be effectively improved, and promote effective self-healing of gynecological disease；
(2) Chinese medicine preparation of the present invention is external preparation, thus the system that will not stimulate digestion, simultaneously for genitals such as vaginas
Official is also without any excitant；
(3) Chinese medicine preparation of the present invention have sterilization bacteriostasis, can effectively remove vagina and uterus metabolism product and
Toxin, to vaginitis, adnexitis, pelvic infecton, cervical erosion, endometritis, fibroid, gynaecology's tumour, abnormal leucorrhea, scabies
Itching etc. has the effect of fine；
Meanwhile Chinese medicine preparation of the present invention can also be effectively improved microcirculation, dispelling stain point, make skin moist pale
High resilience；
Further, Chinese medicine preparation of the present invention also has regulation menstruation, is effectively improved the symptoms such as menstrual period dysmenorrhoea, soreness and weakness of waist and knees
The effect of, and vaginal relaxation can be effectively improved；
(4) preparation method simple process of the present invention, it is simple to operate, and without using large-scale instrument, suitable for industrialization, big rule
The production and preparation of mould.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition suggested according to normal condition or manufacturer are carried out.Agents useful for same or the unreceipted production firm person of instrument, it is
The conventional products that can be obtained by commercially available purchase.
In view of the shortcomings of therapeutic effect present in existing gynaecological disease healing potion is poor, easily recurrence, and side effect is big, this hair
Bright spy provides a kind of Chinese medicine preparation that is new, having promotion uterus toxin expelling effect, and by thoroughly cleaning uterus and reproduction
System, to realize effective treatment for gynecological disease.
Specifically, the raw material of Chinese medicine preparation provided by the present invention is as follows：Ginkgo leaf, field pennycress, Verbena officinalis, kuh-seng, Chinese toon
White skin, frutus cnidii, the tuber of stemona, rhizoma atractylodis, blood scorpion, safflower, peppermint grass, and Chinese gall；
Wherein, ginkgo leaf has promoting blood circulation and removing blood stasis, removes obstruction in channels to relieve pain, and astringes the lung and relievings asthma, the effect of changing turbid lipid-loweringing；Field pennycress has clear
Thermal detoxification, the effect of promoting blood circulation to remove blood stasis apocenosis；Verbena officinalis has the effect of clearing heat and detoxicating, promoting blood circulation to remove blood stasis, inducing diuresis for removing edema；Kuh-seng has
Heat-clearing and damp-drying drug, desinsection, the effect of diuresis；The bark of the root or stem of the tree of heaven has except heat, eliminating dampness, puckery intestines, hemostasis, the effect of desinsection；Frutus cnidii has
Warming kidney and enhancing body, eliminating dampness, wind-dispelling, the effect of desinsection；The tuber of stemona has the effect of moistening the lung and relieve the cough, desinsection；Rhizoma atractylodis have drying damp and strengthening spleen, dispel
Wind, dissipating cold, the effect of improving eyesight；Blood scorpion has a promoting blood circulation to remove blood stasis, analgesic therapy, hemostasia and promoting granulation, the effect of sore；Safflower has promoting blood circulationization
The stasis of blood, Yu Kaijie is dissipated, the effect of analgesic；Peppermint grass has the effect of dispelling wind and heat from the body, head clearing, relieving sore-throat, promoting eruption, soothing liver-qi stagnation；
Chinese gall has the effect of fall fire of astringing the lung, relieving diarrhea with astringents, arrest sweating hemostasis, hygroscopic sore.
By by each raw material compounding use with as above effect, so that Chinese medicine preparation of the present invention can be removed effectively
Vagina and the product and toxin of uterus metabolism, play good therapeutic effect, while can also play improvement for gynecological disease
Skin quality, regulation menstruation and other effects.
Preferably, in parts by weight, Chinese medicine preparation of the present invention is made up of following raw material：15~25 parts of ginkgo leaf, example
It such as can be, but be not limited to 16,17,18,19,20,21,22,23, or 24 parts；15~25 parts of field pennycress, such as can be,
But it is not limited to 16,17,18,19,20,21,22,23, or 24 parts；15~25 parts of Verbena officinalis, such as can be, but be not limited to
16th, 17,18,19,20,21,22,23, or 24 parts；5~10 parts of kuh-seng, such as can be, but it is not limited to 6,7,8, or 9
Part；5~10 parts of the bark of the root or stem of the tree of heaven, such as can be, but it is not limited to 6,7,8, or 9 parts；3~10 parts of frutus cnidii, such as can be, but
It is not limited to 4,5,6,7,8, or 9 parts；3~10 parts of the tuber of stemona, such as can be, but it is not limited to 4,5,6,7,8, or 9 parts；Rhizoma atractylodis
5~12 parts, such as can be, but it is not limited to 6,7,8,9,10, or 11 parts；5~12 parts of blood scorpion, such as can be, but it is unlimited
In 6,7,8,9,10, or 11 parts；5~12 parts of safflower, such as can be, but it is not limited to 6,7,8,9,10, or 11 parts；It is thin
10~20 parts of lotus grass, such as can be, but it is not limited to 11,12,13,14,15,16,17,18, or 19 parts；And Chinese gall 5
~12 parts, such as can be, but it is not limited to 6,7,8,9,10, or 11 parts；
It is furthermore preferred that in parts by weight, Chinese medicine preparation of the present invention is made up of following raw material：18~20 parts of ginkgo leaf,
18~20 parts of field pennycress, 18~20 parts of Verbena officinalis, 6~8 parts of kuh-seng, 6~8 points of the bark of the root or stem of the tree of heaven, 5~8 parts of frutus cnidii, the tuber of stemona 5~8
Part, 8~10 parts of rhizoma atractylodis, 8~10 parts of blood scorpion, 8~10 parts of safflower, 15~18 parts of peppermint grass, and 8~10 parts of Chinese gall.
By the further restriction to each raw material components dosage, it further can improve and optimize Chinese medicine preparation of the present invention
Therapeutic effect.
And as described above Chinese medicine preparation preparation method refer to it is as follows：
First, be by each component heating extraction as described above, it is preferred that Extraction solvent used in extraction be concentration be 75~
85% ethanol, its dosage are 4~6 times of raw material components gross mass to be extracted；
Meanwhile in order to improve the extraction efficiency to each raw material, can also be before extraction to each original in preparation method of the present invention
Material is infiltrated, and infiltration agents useful for same is preferably Extraction solvent, and the time of infiltration is preferably controlled in 3~6h；And by right
Each raw material is infiltrated in advance, it is thus possible to during further heating extraction, is improved to active ingredient in each raw material
Extraction efficiency, and improve the utilization rate of raw material；
During heating extraction, it is preferred that system temperature reach 70~100 DEG C (such as can with it is to be extracted in vivo temperature
After degree reaches 75,80,85,90, or 95 DEG C) after, extract solution is discharged in the lower end of extractor, meanwhile, in the upper end of extractor
New Extraction solvent is supplemented into extractor；The perseverance that the addition speed of Extraction solvent is all contacted simultaneously with each raw material with Extraction solvent
Alignment flow velocity carry out, so as to realize for Extraction solvent and addition and extract solution liquid outlet quantity control (and preferably control carry
Take solvent addition and extract solution liquid outlet quantity it is suitable)；And by lasting molten with " fresh " extraction of low extract concentrations
Agent is extracted, and can effectively improve extraction efficiency, is also beneficial to the further utilization rate for improving raw material；
From the extract solution that extractor lower end is discharged after preferably filtering was carried out, concentrated, it is preferred that be to evaporate
Concentration is evaporated in device, and is further preferably evaporated concentration under vacuum；
Gained concentrate is remained in evaporator after evaporation and concentration, and then interval is discharged, and resulting in evaporation process
Steam, then reclaimed after condensation, the solvent being recovered to can reuse as Extraction solvent, and this also can be further
Effectively improve the utilization rate of Materials Solvents；
The concentrate discharged from evaporator is further handled through vacuum distillation, and obtains mucus, and gained mucus is passing through
After processing is further dried, the extract of solid-state is obtained；
Finally, it is ball by the extract flashing of solid-state, it is preferred that the quality control of pill is in 1g/ balls, as described Chinese medicine
Preparation, and Chinese medicine preparation provided by the present invention is actually also a kind of Chinese medicine preparation pill.
Preparation method as described above can be further summarized as follows：
(a) after each raw material of formula ratio being infiltrated into 3~6h with 75~85% ethanol, add in extractor；Then, to extraction
75~85% ethanol of 4~6 times of amounts is added in tank, carries out heating extraction；
After the temperature in extractor reaches 70~100 DEG C, extract solution is discharged in the lower end of extractor, meanwhile, extracting
The upper end of tank supplements new Extraction solvent into extractor；
(b) enter evaporator after the extract solution filtering of extractor lower end discharge, and evaporate under vacuum, and condense back
Receive evaporation gained steam；
(c) evaporation gained concentrate is evaporated under reduced pressure to obtain mucus, and solids extraction thing is obtained after drying；
(d) it is ball by solids extraction thing flashing, the quality control of pill is used for uterus toxin expelling in 1g/ balls, the as present invention
Chinese medicine preparation.
And the application method of Chinese medicine preparation of the present invention is also relatively simple, Chinese medicine preparation can be put after menstruation terminates 5d
Enter intravaginal, after being spaced 2d, then rejoin Chinese medicine preparation, and continued treatment.
Embodiment 1
According to mass fraction, 25 parts of ginkgo leaf, 25 parts of field pennycress, 25 parts of Verbena officinalis, 5 parts of kuh-seng, the bark of the root or stem of the tree of heaven 5 divides, cnidium monnieri
3 parts of son, 10 parts of the tuber of stemona, 5 parts of rhizoma atractylodis, 12 parts of blood scorpion, 12 parts of safflower, 10 parts of peppermint grass, and 12 parts of Chinese gall, weigh respectively
Appropriate each raw material；
Then, it is prepared as follows the Chinese medicine preparation of embodiment 1：
(a) after as above each raw material being infiltrated into 5h with 75% ethanol, add in extractor；Then, 5 are added into extractor
75% ethanol of amount again, carry out heating extraction；
After the temperature in extractor reaches 80 DEG C, extract solution is discharged in the lower end of extractor, meanwhile, in the upper of extractor
Hold and new Extraction solvent is supplemented into extractor；
(b) enter evaporator after the extract solution filtering of extractor lower end discharge, and evaporate under vacuum, and condense back
Receive evaporation gained steam；
(c) evaporation gained concentrate is evaporated under reduced pressure to obtain mucus, and solids extraction thing is obtained after drying；
(d) it is ball by solids extraction thing flashing, the quality control of pill is arranged in 1g/ balls, the uterus that is used for of as embodiment 1
The Chinese medicine preparation of poison.
Embodiment 2
According to mass fraction, 15 parts of ginkgo leaf, 15 parts of field pennycress, 15 parts of Verbena officinalis, 10 parts of kuh-seng, the bark of the root or stem of the tree of heaven 10 divides, snake
10 parts of machine tool, 3 parts of the tuber of stemona, 12 parts of rhizoma atractylodis, 5 parts of blood scorpion, 5 parts of safflower, 20 parts of peppermint grass, and 5 parts of Chinese gall, weigh respectively
Appropriate each raw material；
Then, it is prepared as follows the Chinese medicine preparation of embodiment 2：
(a) after as above each raw material being infiltrated into 5h with 75% ethanol, add in extractor；Then, 5 are added into extractor
75% ethanol of amount again, carry out heating extraction；
After the temperature in extractor reaches 80 DEG C, extract solution is discharged in the lower end of extractor, meanwhile, in the upper of extractor
Hold and new Extraction solvent is supplemented into extractor；
(b) enter evaporator after the extract solution filtering of extractor lower end discharge, and evaporate under vacuum, and condense back
Receive evaporation gained steam；
(c) evaporation gained concentrate is evaporated under reduced pressure to obtain mucus, and solids extraction thing is obtained after drying；
(d) it is ball by solids extraction thing flashing, the quality control of pill is arranged in 1g/ balls, the uterus that is used for of as embodiment 2
The Chinese medicine preparation of poison.
Embodiment 3
According to mass fraction, 18 parts of ginkgo leaf, 18 parts of field pennycress, 18 parts of Verbena officinalis, 6 parts of kuh-seng, the bark of the root or stem of the tree of heaven 6 divides, cnidium monnieri
5 parts of son, 5 parts of the tuber of stemona, 8 parts of rhizoma atractylodis, 8 parts of blood scorpion, 8 parts of safflower, 15 parts of peppermint grass, and 8 parts of Chinese gall, weigh appropriate respectively
Each raw material；
Then, it is prepared as follows the Chinese medicine preparation of embodiment 3：
(a) after as above each raw material being infiltrated into 5h with 75% ethanol, add in extractor；Then, 5 are added into extractor
75% ethanol of amount again, carry out heating extraction；
After the temperature in extractor reaches 80 DEG C, extract solution is discharged in the lower end of extractor, meanwhile, in the upper of extractor
Hold and new Extraction solvent is supplemented into extractor；
(b) enter evaporator after the extract solution filtering of extractor lower end discharge, and evaporate under vacuum, and condense back
Receive evaporation gained steam；
(c) evaporation gained concentrate is evaporated under reduced pressure to obtain mucus, and solids extraction thing is obtained after drying；
(d) it is ball by solids extraction thing flashing, the quality control of pill is arranged in 1g/ balls, the uterus that is used for of as embodiment 3
The Chinese medicine preparation of poison.
Embodiment 4
According to mass fraction, 20 parts of ginkgo leaf, 20 parts of field pennycress, 20 parts of Verbena officinalis, 8 parts of kuh-seng, the bark of the root or stem of the tree of heaven 8 divides, cnidium monnieri
8 parts of son, 8 parts of the tuber of stemona, 10 parts of rhizoma atractylodis, 10 parts of blood scorpion, 10 parts of safflower, 18 parts of peppermint grass, and 10 parts of Chinese gall, weigh respectively
Appropriate each raw material；
Then, it is prepared as follows the Chinese medicine preparation of embodiment 4：
(a) after as above each raw material being infiltrated into 5h with 75% ethanol, add in extractor；Then, 5 are added into extractor
75% ethanol of amount again, carry out heating extraction；
After the temperature in extractor reaches 80 DEG C, extract solution is discharged in the lower end of extractor, meanwhile, in the upper of extractor
Hold and new Extraction solvent is supplemented into extractor；
(b) enter evaporator after the extract solution filtering of extractor lower end discharge, and evaporate under vacuum, and condense back
Receive evaporation gained steam；
(c) evaporation gained concentrate is evaporated under reduced pressure to obtain mucus, and solids extraction thing is obtained after drying；
(d) it is ball by solids extraction thing flashing, the quality control of pill is arranged in 1g/ balls, the uterus that is used for of as embodiment 4
The Chinese medicine preparation of poison.
Embodiment 5
According to mass fraction, 18 parts of ginkgo leaf, 18 parts of field pennycress, 18 parts of Verbena officinalis, 6 parts of kuh-seng, the bark of the root or stem of the tree of heaven 6 divides, cnidium monnieri
5 parts of son, 5 parts of the tuber of stemona, 8 parts of rhizoma atractylodis, 8 parts of blood scorpion, 8 parts of safflower, 15 parts of peppermint grass, and 8 parts of Chinese gall, weigh appropriate respectively
Each raw material.
Then, the method for reference implementation example 1 prepares the Chinese medicine preparation of Chinese medicine preparation, as embodiment 5；
Wherein, in the preparation method step (a) of embodiment 5, it is after temperature in extractor reaches 70 DEG C, then is extracting
The lower end discharge extract solution of tank, meanwhile, new Extraction solvent is supplemented into extractor in the upper end of extractor.
Embodiment 6
According to mass fraction, 18 parts of ginkgo leaf, 18 parts of field pennycress, 18 parts of Verbena officinalis, 6 parts of kuh-seng, the bark of the root or stem of the tree of heaven 6 divides, cnidium monnieri
5 parts of son, 5 parts of the tuber of stemona, 8 parts of rhizoma atractylodis, 8 parts of blood scorpion, 8 parts of safflower, 15 parts of peppermint grass, and 8 parts of Chinese gall, weigh appropriate respectively
Each raw material.
Then, it is prepared as follows the Chinese medicine preparation of embodiment 6：
(a) after as above each raw material being infiltrated into 5h with 75% ethanol, add in extractor；Then, 5 are added into extractor
75% ethanol of amount again, carry out heating extraction；
After the heating-up temperature of extractor reaches 80 DEG C, persistently extracted under heat-retaining condition, until the volume of extract solution is to carry
The 1/5 of solvent adding amount is taken, extract solution is discharged in the lower end of extractor；
(b) enter evaporator after the extract solution filtering of extractor lower end discharge, and evaporate under vacuum, and condense back
Receive evaporation gained steam；
(c) evaporation gained concentrate is evaporated under reduced pressure to obtain mucus, and solids extraction thing is obtained after drying；
(d) it is ball by solids extraction thing flashing, the quality control of pill is arranged in 1g/ balls, the uterus that is used for of as embodiment 6
The Chinese medicine preparation of poison.
Comparative example 1
According to mass fraction, 18 parts of ginkgo leaf, 27 parts of field pennycress, 6 parts of kuh-seng, the bark of the root or stem of the tree of heaven 6 divides, 6 parts of frutus cnidii, the tuber of stemona 5
Part, 8 parts of rhizoma atractylodis, 12 parts of blood scorpion, 12 parts of safflower, 15 parts of peppermint grass, and 8 parts of Chinese gall, appropriate each raw material is weighed respectively.
Then, the Chinese medicine preparation of comparative example 1 is prepared Following the procedure of Example 1.
Comparative example 2
According to mass fraction, 18 parts of ginkgo leaf, 18 parts of field pennycress, 18 parts of Verbena officinalis, 6 parts of kuh-seng, the bark of the root or stem of the tree of heaven 6 divides, cnidium monnieri
8 parts of son, 8 parts of the tuber of stemona, 10 parts of blood scorpion, 8 parts of safflower, 15 parts of peppermint grass, and 8 parts of Chinese gall, weigh appropriate each raw material respectively.
Then, the Chinese medicine preparation of comparative example 2 is prepared Following the procedure of Example 1.
Comparative example 3
According to mass fraction, 20 parts of ginkgo leaf, 20 parts of field pennycress, 20 parts of Verbena officinalis, 6 parts of kuh-seng, the bark of the root or stem of the tree of heaven 6 divides, cnidium monnieri
5 parts of son, 5 parts of the tuber of stemona, 8 parts of rhizoma atractylodis, 10 parts of blood scorpion, 8 parts of safflower, and 15 parts of peppermint grass, weigh appropriate each raw material respectively.
Then, the Chinese medicine preparation of comparative example 3 is prepared Following the procedure of Example 1.
Experimental example 1
(1) toxicity research
It is respectively medicament to be detected by 1-6 of embodiment of the present invention Chinese medicine preparation, and is tested as follows：
(i), there is not abnormal response in chmice acute toxicological experiment, its mouse oral acute toxinology experiment, equivalent to the mankind
It is safe to use during 1000 times of dosage；
(ii) rat vagina mucosal irritation is tested：Multiple dosing, rat are showed no abnormal response, and vagina mucosa thing is obvious
Excitant；
(iii) allergic reaction on guinea pigs：Embodiment 1-6 Chinese medicine preparation, without sensitization, does not occur to guinea pig skin
Erythema or oedema phenomenon；
(iv) rat chronic toxicity test：Rat 30d is continuously fed with embodiment 1-6 Chinese medicine preparation, not found big
There is uncomfortable or dead phenomenon in mouse.
And from toxicity test as above, the safe and non-stimulating property of Chinese medicine preparation of the embodiment of the present invention, and have no toxic side effect,
It is adapted as external used medicine use.
(2) drug efficacy study
By northern somewhere clinical pharmacology base, discussed through Ethics Committee, pass through II phase double blind schemes
Afterwards, agree to carry out clinical research.In northern somewhere hospital to being that the patient of vaginitis, cervicitis or cervical erosion enters after diagnosing
Row clinical treatment is observed, all to participate in the experiment equal voluntary participation of patient, and is grouped at random respectively with embodiment 1-6 and comparative example
1-3 Chinese medicine preparation is treated.
Treatment method is as follows：After menstruation terminates 5d, Chinese medicine preparation is put into intravaginal, after being spaced 2d, then rejoined
Chinese medicine preparation, arrive and terminate to next menstruation, and continued treatment 3 months, it is as a result as follows：
From experimental result as above, for the comparative example Chinese medicine preparation compared to component missing, Chinese medicine system of the present invention
Agent is substantially significantly superior on efficient and cure rate, it can be seen that, by effective compatibility effect of each component, can realize
More preferable therapeutic effect, and component missing can cause the uncoordinated of compatibility, and cause drug effect to substantially reduce；
Meanwhile contrasted from the therapeutic effect of embodiment 1,2 and embodiment 3,4, each component usage ratio is for treatment
Effect is equally to have certain influence, and the optimization that usage ratio is formulated to each component is also beneficial to improve drug effect；
Further, contrasted from the therapeutic effect of embodiment 3 and embodiment 5,6, the extracting method pair of Chinese medicine preparation
Equally it is to have certain influence in drug effect, and uses currently preferred extracting mode, can be further effectively improved and control
Therapeutic effect.
Meanwhile during effect experiment, it is all participate in experiment patients feed back no matter Chinese medicine system of the embodiment of the present invention
Agent or comparative example Chinese medicine preparation, without any excitant, and over the course for the treatment of, do not occur other adverse reactions yet.
Further, each group patient is paid a return visit after testing 6 months, uses the Chinese medicine system of the embodiment of the present invention 3,4
The phenomenon that the patient that agent is treated feeds back conventional irregular menstruation or dysmenorrhoea substantially makes moderate progress or disappeared substantially, and skin
Matter also substantially improves；And the patient treated using the Chinese medicine preparation of embodiment 1,2,5 feed back conventional irregular menstruation or
The phenomenon of dysmenorrhoea makes moderate progress, and skin quality has also taken a turn for the better；Meanwhile use the trouble treated of Chinese medicine preparation of embodiment 6
The phenomenon that person feeds back conventional irregular menstruation or dysmenorrhoea slightly improves.
(3) typical treatment case：
Case one：Zhao has a period to feel that underbelly does not relax for 50 years old, pruritus vulvue, is diagnosed as colpomycosis, eats west
Medicine is not felt any better for a period of time, and with this product, two disappear with regard to all symptoms.
Case two：Liu suffers from trichomonas vaginitis in 56 years old on inspection, with discharging many green purulence shape things after this product one, after
Continue clean with a body, consolidated again with 2 after one month, there is no sense of discomfort for body.
Case three：38 years old face of Lee is gloomy, frequent dry and hard excrement, 3-5 talent's solution time hands.It is cervical erosion on inspection,
Improved with situation of being defecated after this product 2, second month face, which is had a good complexion, goes to the elimination of examination in hospital cervical erosion.
Case four：History has ovarian cyst in 32 years old, with discharging a large amount of fouls after this product 2, second month outflow dirt, and 3
Check that tumour disappears after individual month.
Case five：Underbelly feels bad pain often before 28 years old menstrual period of poplar arrive, and menses are black dull sticky, draws leaching more than ten sometimes
My god, with this product the first month, underbelly be just obviously improved it is comfortable more, reddened after 2 months through blood color.
Although illustrate and describing the present invention with specific embodiment, but will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
- A kind of 1. Chinese medicine preparation for uterus toxin expelling, it is characterised in that the Chinese medicine preparation for uterus toxin expelling mainly by Following components is made：Ginkgo leaf, field pennycress, Verbena officinalis, kuh-seng, the bark of the root or stem of the tree of heaven, frutus cnidii, the tuber of stemona, rhizoma atractylodis, blood scorpion, safflower, peppermint grass, and Chinese gall.
- 2. the Chinese medicine preparation according to claim 1 for uterus toxin expelling, it is characterised in that in parts by weight, institute State and be mainly made up for the Chinese medicine preparation of uterus toxin expelling of following components：15~25 parts of ginkgo leaf, 15~25 parts of field pennycress, 15~25 parts of Verbena officinalis, 5~10 parts of kuh-seng, 5~10 points of the bark of the root or stem of the tree of heaven, snake 3~10 parts of machine tool, 3~10 parts of the tuber of stemona, 5~12 parts of rhizoma atractylodis, 5~12 parts of blood scorpion, 5~12 parts of safflower, 10~20 parts of peppermint grass, And 5~12 parts of Chinese gall.
- 3. the Chinese medicine preparation according to claim 1 for uterus toxin expelling, it is characterised in that in parts by weight, institute State and be mainly made up for the Chinese medicine preparation of uterus toxin expelling of following components：18~20 parts of ginkgo leaf, 18~20 parts of field pennycress, 18~20 parts of Verbena officinalis, 6~8 parts of kuh-seng, 6~8 points of the bark of the root or stem of the tree of heaven, cnidium monnieri 5~8 parts of son, 5~8 parts of the tuber of stemona, 8~10 parts of rhizoma atractylodis, 8~10 parts of blood scorpion, 8~10 parts of safflower, 15~18 parts of peppermint grass, and 8~10 parts of Chinese gall.
- 4. it is used for the preparation method of the Chinese medicine preparation of uterus toxin expelling any one of claim 1-3, it is characterised in that described Preparation method comprises the following steps：By each component heating extraction any one of claim 1-3, and distill, dry after gained extract solution is concentrated, Solids extraction thing is obtained, flashing is ball, as described Chinese medicine preparation.
- 5. preparation method according to claim 4, it is characterised in that each component any one of claim 1-3 It is after first being infiltrated with Extraction solvent, adds Extraction solvent and carry out heating extraction；Preferably, the time of the infiltration is 3~6h.
- 6. preparation method according to claim 4, it is characterised in that the Extraction solvent includes 75~85% ethanol；And/or the gross mass that the quality of Extraction solvent used in heating extraction is each component any one of claim 1-3 4~6 times.
- 7. preparation method according to claim 6, it is characterised in that the heating extraction is carried out in extractor, and Temperature discharges extract solution after reaching 70~100 DEG C, while new Extraction solvent is supplemented into extractor.
- 8. preparation method according to claim 4, it is characterised in that the concentration further comprises to be concentrated by evaporation The step of recycling of condensed steam is recycled；And/or the distillation is vacuum distillation.
- 9. the Chinese medicine preparation for uterus toxin expelling any one of claim 1-3 is preparing removing vagina and uterus metabolism Application in product and toxin pharmaceutical；And/or preparing the application in adjusting menstruation medicine；And/or preparing the application in improving vaginal relaxation medicine.
- 10. the Chinese medicine preparation for uterus toxin expelling any one of claim 1-3 improves microcirculation, removed preparing Application in color spot medicine.
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| CN110251578A (en) * | 2019-07-04 | 2019-09-20 | 江西樟树市正康医药生物科技有限公司 | It is a kind of for koro and the drug of gynaecological imflammation and preparation method thereof |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110251578A (en) * | 2019-07-04 | 2019-09-20 | 江西樟树市正康医药生物科技有限公司 | It is a kind of for koro and the drug of gynaecological imflammation and preparation method thereof |
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Application publication date: 20171110 |