CN106265835A - A kind of Chinese medicine composition treating tubal obstruction barrenness and application thereof - Google Patents
A kind of Chinese medicine composition treating tubal obstruction barrenness and application thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition treating tubal obstruction barrenness, described Chinese medicine composition is made up of the crude drug of following weight portion: Fructus Liquidambaris 2 10 parts, Semen Vaccariae 10 20 parts, Semen Aesculi 10 20 parts.The invention still further relates to the application in preparation treatment tubal obstruction barrenness medicine of the above-mentioned Chinese medicine composition, the dosage form of medicine includes capsule, granule, tablet, oral liquid, mixture or syrup.The Chinese medicine composition flavour of a drug number of the present invention is few, abundant raw materials, and preparation technology is simple, environmentally friendly, and through zoopery and clinical trial, the Chinese medicine composition of the present invention is notable for treatment tubal obstruction barrenness therapeutic effect, has a good application prospect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically, be a kind of Chinese medicine composition treating tubal obstruction barrenness
Thing and application thereof.
Background technology
Infertility refers to child-bearing period woman after marriage or after last gestation, matrimonial cohabitation more than 2 years, bridegroom's or husband's side reproduction merit
Can be normal, do not practise contraception and do not become pregnant for the main disease showed.The reason causing infertility include female ovulation obstacle or
Do not ovulate, obstruction of fallopian tube, dysfunction, inflammation, tuberculosis or endometriosis, immune factor and habitual abortion are made
Become infertile etc..Modern medicine takes different Therapeutic Method according to the different infertile causes of disease.
Infertility caused by fallopian tube obstruction mainly salpingitis causes, owing to various factors causes fallopian tube tube wall muscle to be received
Contracting miopragia, epithelial cilia wriggle go down, salpingitis tubal, fallopian tube adhesion, hydrops or obstruction, tuberculosis of fallopian tube etc., draw
Play fallopian tube to take the photograph and pick up ovum, in time transport germ cell and enter the afunction of uterine cavity implantation, and cause infertile.Clinical manifestation master
To be characterized with infertile, with menorrhagia, menostaxis, dark red through color, accompany clot, hypogastralgia, waist sacrum distending pain, through row
Stomachache, leukorrhagia exception, susceptible to lose temper due to restlessness, susceptible fatigue etc., gynecological's inspection has the sign of pelvic inflammatory disease more.Primary disease is common, refractory
Disease, sickness rate raises year by year, during discovery has formed irreversible fallopian tube pathological changes more, the serious body and mind affecting numerous women
Health and quality of life, bring financial burden to patient home, society.
Prior art discloses the Chinese medicine composition of multiple treatment obstruction of fallopian tube, such as Chinese patent 2010102291588,
Disclosing a kind of Chinese medicine composition treating salpingemphraxis and its production and use, the Chinese medicine by following weight proportion is former
Material is prepared from: Radix Angelicae Sinensis 6～12 parts, Radix Paeoniae Rubra, 6～12 parts, Fructus Liquidambaris 5～9 parts, Rhizoma Cyperi 6～12 parts, and Radix Bupleuri 3～9 parts are strongly fragrant
Gold 3～9 parts, Spina Gleditsiae 3～9 parts, beans grass 9～15 parts, Caulis Sargentodoxae 9～15 parts.This Chinese medicine composition is through zoopery and clinic
Verification experimental verification, therapeutic effect is notable.Chinese patent 2013103133710, discloses a kind of Chinese drug-treated group treating salpingemphraxis
Compound, is made up of the crude drug of following weight portion: Radix Salviae Miltiorrhizae 15-25 part, Herba Leonuri 10-20 part, Fructus Liquidambaris 10-20 part, Semen Cuscutae
10-20 part, Radix Achyranthis Bidentatae 10-20 part, Radix Curcumae 7-13 part, Radix Paeoniae Rubra 7-13 part, Rhizoma Chuanxiong 7-13 part, Rhizoma Sparganii 7-13 part, Rhizoma Curcumae 7-13 part, elder brother
Cloth 7-13 part, Spina Gleditsiae 7-13 part, Oletum Trogopterori 7-13 part, Rhizoma Cyperi 7-13 part, Folium Artemisiae Argyi 7-13 part, Radix Angelicae Sinensis 7-13 part, Radix Et Rhizoma Rhei 7-13
Part, Radix Paeoniae Alba 7-13 part, Herba Epimedii 7-13 part, Semen Vaccariae 7-13 part, Semen Persicae 3-9 part, Myrrha 3-9 part, Pericarpium Citri Reticulatae 2-4 part, Herba Asari
2-4 part, Mylabris 2-4 part, Flos Carthami 2-4 part；This Chinese medicine composition has stable curative effect, treatment time is short, preparation method is simple
Advantage.But in prior art, the Chinese medicine composition treating tubal obstruction barrenness about the present invention, yet there are no report
Road.
Summary of the invention
It is an object of the invention to for deficiency of the prior art, it is provided that a kind of Chinese medicine treating tubal obstruction barrenness
Compositions.
Another purpose of the present invention is to provide the preparation method of Chinese medicine composition described above.
For achieving the above object, the present invention adopts the technical scheme that:
A kind of Chinese medicine composition treating tubal obstruction barrenness, described Chinese medicine composition is former by following weight portion
Material medicine is made: Fructus Liquidambaris 2-10 part, Semen Vaccariae 10-20 part, Semen Aesculi 10-20 part.
Further, described Chinese medicine composition is made up of the crude drug of following weight portion: Fructus Liquidambaris 4-7 part, Semen Vaccariae
13-17 part, Semen Aesculi 13-17 part.
Further, described Chinese medicine composition is made up of the crude drug of following weight portion: Fructus Liquidambaris 5 parts, Semen Vaccariae 15
Part, Semen Aesculi 15 parts.
For realizing above-mentioned second purpose, the present invention adopts the technical scheme that:
The application in preparation treatment tubal obstruction barrenness medicine of arbitrary described Chinese medicine composition.
Further, described infertility Chinese medical discrimination belongs to cold-damp stasis type.
Further, described medicine adds pharmaceutically acceptable carrier as required and is prepared as any pharmaceutical dosage form.
Further, described medicine also includes the adjuvant pharmaceutically allowed.
Further, the dosage form of described medicine is capsule, granule, tablet, oral liquid, mixture or syrup.
Further, described pharmaceutically acceptable carrier includes but not limited to: mannitol, sorbitol, sodium pyrosulfite, sulfurous
Acid hydrogen sodium, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, injection Vitamin B_6 DTA disodium, Ethylenediaminetetraacetic Acid Calcium Salt, monovalence
Alkali-metal carbonate, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, chlorination
Potassium, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol,
Silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate,
Calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, stearic acid
Calcium, magnesium stearate.
The invention has the advantages that:
1, the Chinese medicine composition of the present invention can be effectively improved the clinical symptoms of salpingitic infecundity disease of cold-damp stasis type
And sign, hence it is evident that improve the probability of fallopian tube reconstruction.
2, in the Chinese medicine composition of the present invention, Semen Aesculi has obvious synergism with other Chinese medicine, improves greatly
The compositions improvement effect to infertility clinical symptoms, curative effect is more preferably.
The advantages such as 3, the medicine of the present invention is made up of pure Chinese medicine, has and has no side effect, and price is low, it is easy to connect by patient
It is subject to.
4, the medicine flavour of a drug number of the present invention is few, abundant raw materials, and preparation technology is simple, environmentally friendly, real through animal
Test and clinical trial, notable for treatment tubal obstruction barrenness therapeutic effect, have a good application prospect.
5, the proportioning of Chinese medicine composition of the present invention is obtained by great many of experiments screening, have good effect, effect notable,
The advantage being difficult to recurrence.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is expanded on further.Should be understood that these embodiments are merely to illustrate this
Bright rather than limit the scope of the present invention.In addition, it is to be understood that after having read the content that the present invention records, art technology
The present invention can be made various changes or modifications by personnel, and these equivalent form of values fall within the application appended claims equally and limited
Fixed scope.
Embodiment 1 present invention treats the preparation () of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 5 parts, Semen Vaccariae 15 parts, Semen Aesculi 15 parts.By the system that Chinese medicine decoction is conventional
Make method, described crude drug boiling is become decoction.
Embodiment 2 present invention treats the preparation (two) of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 2 parts, Semen Vaccariae 10 parts, Semen Aesculi 10 parts.By the system that Chinese medicine decoction is conventional
Make method, described crude drug boiling is become decoction.
Embodiment 3 present invention treats the preparation (three) of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 10 parts, Semen Vaccariae 10 parts, Semen Aesculi 10 parts.By Chinese medicine decoction routine
Manufacture method, becomes decoction by described crude drug boiling.
Embodiment 4 present invention treats the preparation (four) of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 10 parts, Semen Vaccariae 20 parts, Semen Aesculi 10 parts.By Chinese medicine decoction routine
Manufacture method, becomes decoction by described crude drug boiling.
Embodiment 5 present invention treats the preparation (five) of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 10 parts, Semen Vaccariae 20 parts, Semen Aesculi 20 parts.By Chinese medicine decoction routine
Manufacture method, becomes decoction by described crude drug boiling.
Embodiment 6 present invention treats the preparation (six) of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 4 parts, Semen Vaccariae 13 parts, Semen Aesculi 13 parts.By the system that Chinese medicine decoction is conventional
Make method, described crude drug boiling is become decoction.
Embodiment 7 present invention treats the preparation (seven) of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 7 parts, Semen Vaccariae 13 parts, Semen Aesculi 13 parts.By the system that Chinese medicine decoction is conventional
Make method, described crude drug boiling is become decoction.
Embodiment 8 present invention treats the preparation (eight) of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 7 parts, Semen Vaccariae 17 parts, Semen Aesculi 13 parts.By the system that Chinese medicine decoction is conventional
Make method, described crude drug boiling is become decoction.
Embodiment 9 present invention treats the preparation (nine) of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 7 parts, Semen Vaccariae 17 parts, Semen Aesculi 17 parts.By the system that Chinese medicine decoction is conventional
Make method, described crude drug boiling is become decoction.
Embodiment 10 present invention treats the preparation (ten) of tubal obstruction barrenness medicine
Weigh raw material by weight: Fructus Liquidambaris 6 parts, Semen Vaccariae 15 parts, Semen Aesculi 16 parts.By the system that Chinese medicine decoction is conventional
Make method, described crude drug boiling is become decoction.
Embodiment 11 treats the preparation of tubal obstruction barrenness medicinal tablet/capsule
The arbitrary described medicine of Example 1-10, adds 8-12 times amount water, decocts 1-3 hour, leach medicine juice.Add 10 times again
Amount water, decocts 1.5-2.5 hour, leaches medicine juice, merges secondary decocting liquid, stands, leaching supernatant, concentrates, lets cool, add concentrated solution
2.5 times amount ethanol, stir precipitates overnight.Take supernatant, be concentrated into thick extractum；Add pharmaceutical aids, vacuum drying, pulverize system
Grain, is pressed into tablet or fills encapsulated.
Embodiment 12 treats the preparation of tubal obstruction barrenness drug particles
The arbitrary described medicine of Example 1-10, adds 8-10 times amount water, decocts 2.5-3.5 hour, leach medicine juice.Add again
10 times amount water, decoct 2 hours, leach medicine juice, merge secondary decocting liquid, stand, leaching supernatant, concentrate, let cool, add concentrated solution 2
Times amount ethanol, stirs precipitates overnight.Take supernatant, be concentrated into thick extractum；Add suitable pharmaceutical aids, pelletize, be dried, granulate,
20g granule, subpackage 10g/ bag.
Embodiment 13 treats the preparation of tubal obstruction barrenness drug mixture/oral liquid/syrup
The arbitrary described medicine of Example 1-10, adds 8-10 times amount water, decocts 3 hours, leach medicine juice.Add 8 times amount again
Water, decocts 2 hours, leaches medicine juice, merges secondary decocting liquid, stands, leaching supernatant, concentrates, lets cool, add concentrated solution 2 times amount wine
Essence, stirs precipitates overnight.Take supernatant, be concentrated into thick extractum；Add suitable pharmaceutical aids, make mixture, oral liquid or syrup.
Embodiment 13 treats the zoopery of tubal obstruction barrenness curative effect of medication
One, materials and methods
1.1 experiment material
1.1.1 animal
Wistar rat 72, female, 4-6 week old, body weight 180-200g, cleaning grade, Chinese Academy of Sciences Shanghai test
Animal center provides, and conventional raising, illumination every day 12h, 21d wean age, give normal rat pellet.
1.1.2 medicine and reagent
The Chinese medicine composition of the present invention；Adrenalin hydrochloride；Glacial acetic acid；Liquefied phenol；Arabic gum；Glycerol.
The foundation of 1.2 animal models
The preparation of 20% Hydroxybenzene mucilage: liquefied phenol 5ml, arabic gum 1g, glycerol 4ml, add distilled water, furnishing pasty state.
Modeling method: with pentobarbital sodium (25mg/kg) lumbar injection, after anaesthetizing 10-15 minute, disappears with iodine tincture, ethanol
Poison, opens abdominal cavity, injects 20% Hydroxybenzene mucilage, sewing-up cut at fallopian tube respectively in two oviductus lateraliss in uterus.
1.3 packets and administration
Selection Model rat, is randomly divided into model group and administration group, often group 12, separately set same batch without modeling female greatly
Mus is Normal group.Administration group rat gives gastric infusion.Rat gives in weight portion described in embodiment 1 wherein treatment group
Drug composition, it is containing crude drug amount 4g/ml that conventional method decocts to concentration, and dosage is 10mg/kg, continuous 30 days；Compare one group
Give the Chinese medicine composition of following weight portion: Fructus Liquidambaris 5 parts, Semen Vaccariae 15 parts, conventional method decocts to concentration as containing
Crude drug amount 4g/ml, dosage is 10mg/kg, continuous 30 days；Compare the two groups of Chinese medicine composition giving following weight portion: Lu Lu
Logical 15 parts, Semen Vaccariae 5 parts, Semen Aesculi 5 parts, it is containing crude drug amount 4g/ml that conventional method decocts to concentration, and dosage is 10mg/
Kg, continuous 30 days；FUYANKANG group dosage is 3g/kg d, continuous 30 days.Model group is steamed with Normal group gavage every day equivalent
Distilled water, equal every day 1 time, continuous 30d.Gavage puts to death rat after 30 days, inject dilution methylene blue solution from uterus to fallopian tube, check
The unimpeded situation of fallopian tube.
1.4 experimental result
Model group rats fallopian tube unimpeded number of cases relatively blank group substantially reduces, and has significant difference (P < 0.05), says
Inject 20% Hydroxybenzene mucilage 0.04ml in bright two oviductus lateraliss and can cause fallopian tube disease.FUYANKANG group, treatment group, comparison one
Group, compare two groups of rat tubal patency number of cases relatively model group and all have increase, wherein FUYANKANG group, treatment group tubal patency bar
Number compares with model group significant difference (P < 0.05).The Chinese medicine composition of the present invention can dramatically increase salpingemphraxis mould
The tubal patency bar number of type rat.
Table 1 is respectively organized rat salpingemphraxis situation and is compared
| Group | n | Fallopian tube bar number | Unobstructed bar number | The most unobstructed bar number |
| Normal group | 12 | 24 | 24 | 0 |
| Model group | 12 | 24 | 5* | 19 |
| FUYANKANG group | 12 | 24 | 13# | 1 |
| Treatment group | 12 | 24 | 20# | 4 |
| Compare one group | 12 | 24 | 8 | 16 |
| Compare two groups | 12 | 24 | 10 | 14 |
Note: compare * P < 0.05 with normal group；Compare with model group, #P < 0.05.
Embodiment 14 treats the clinical trial of tubal obstruction barrenness curative effect of medication
1. clinical data
1.1 physical data
Collecting gynecological's hospitalization, Chinese medical discrimination is the salpingitic infecundity disease patient of cold-damp stasis type.
1.2 diagnostic criteria
1.2.1 Western medicine diagnose standard
" the infertility therapy of combining Chinese and Western medicine " and the 7th edition " obstetrics and gynecology " published with reference to People's Health Publisher:
(1) man and wife lives together 1 year or more than 1 year, and syngamy function is normal, does not take any contraceptives to fail to be subject to
Pregnant person, for infertility.The person that never do not becomes pregnant is primary infertility；Once having gestation, the most continuous 1 year or more than 1 year infertile person, for continuing
The property sent out is infertile.
(2) hysterosalpingography display bilateral salpingo is narrow, adhesion, obstruction or hydrops.
(3) general anesthesia B ultrasonic monitors that descending hysteroscope bilateral salpingo intubates logical liquid and shows: bilateral salpingo is narrow, viscous
Even, obstruction or hydrops.
(4) more than, three are provided simultaneously with, and can make a definite diagnosis.
1.2.2 TCM syndrome diagnostic criteria
With reference to " new Chinese medicine guideline of clinical investigations " and " clinical disease diagnosis is according to curing improvement standard ":
Primary symptom: lower abdomen twinge has creeping chill, sore spot to fix, waist sacrum twinge also accompanies creeping chill.
Secondary disease: coldness of the body with chills；Delayed menstrual cycle, amount is few, and color is purple dark, and abdominal pain during menstruation increases the weight of；Profuse leukorrhea, color white matter is dilute；One
Side or bilateral thicken, and have tenderness, maybe can form lump.
Tongue arteries and veins: dimly pale tongue, tongue is the thickest or satiny, or sees petechia and ecchymosis, deep-rolling pulse.
More than possess primary symptom, be provided simultaneously with time disease 2 or more than 2, the most diagnosable in conjunction with tongue arteries and veins.
1.2.3 salpingemphraxis degree criterion
(1) after hysterosalpingography, result judges:
Tubal patency: P-A Cephalomatrics display contrast agent enters pelvic cavity diffusion.Retardation plate display uterus and fallopian tube image, pelvic cavity
Cloud contrast agent it is dispersed in seen from Nei.
Salpingemphraxis: P-A Cephalomatrics fallopian tube does not develop and blocks for interstitial portion；Develop a bit of for isthmus, ampulla resistance
Plug；Development is to far-end but sees a small amount of contrast agent disperse in retardation plate pelvic cavity, blocks for umbrella end portion；Develop to far-end but retardation plate
Contrast agent disperse is had no, for umbrella end total blockage in pelvic cavity；Fallopian tube distal dilation is lumps or long cryptomere, retardation plate pelvic cavity
Inside have no contrast agent disperse, for hydrosalpinx.
Fallopian tube is logical and smooth or with surrounding tissue adhesion: minority contrast agent enters pelvic cavity, and retardation plate is in fallopian tube and basin
The all visible contrast agent of intracavity, contrast agent enters adhesion gap and is alabastrum shape or accumulates in around fallopian tube in cryptomere not disperse.
1.3 TCM syndrome scalar quantization standards
With reference to " new Chinese medicine guideline of clinical investigations ", according to tcm syndrome primary symptom, the difference of secondary disease and light, in, weight
Difference, sets different score value, normal (0 point) respectively, and slightly (1 point/2 points), moderate (2/4 point) is divided, severe (3 points/6 points), then
Comprehensive each disease scoring summation, contains 1/3 ratio classification of total score (63 points), it is determined that severity extent: slight with Chinese medicine syndrome integral:
Total mark≤21 point, moderate: total mark 22～42 points, severe: total mark > 42 points.
1.4 case selection standards
1.4.1 case inclusive criteria
(1) Western medicine diagnose standard and tcm syndrome syndrome differential diagnosis standard person are met；
(2) 21 years old age～35 years old person；
(3) voluntary participation the person that signs Informed Consent Form.
1.4.2 case exclusion standard
(1) infertile person caused by the reason such as congenital physiological defect or deformity, immunity, heredity, endocrine；
(2) confirm on inspection to be associated with endometriosis, adenomyosis, hysteromyoma person；
(3) cervical lesions or the person that has genital tuberculosis are turned out to be on inspection；
(4) bridegroom's or husband's side reproductive function exception person；
(5) severe primary disease and the psychiatric patients such as cardiovascular, liver, kidney and hemopoietic system it are associated with；
(6) interstitial tubal blocks, isthmus blocks, ampulla obstructor.
1.4.3 case is rejected, come off standard
(1) therapist can not be adhered to；
(2) compliance difference person；
(3) therapeutic process receives other treatment method person；
(4) there is serious adverse events, complication and special physiological change, curer should not be continued；
(5) data is not complete, and affect the treatment judgement person.
1.5 Therapeutic Method
Standard compliant case is randomly divided into one group of Chinese medicine, two groups of Chinese medicine, three groups of Chinese medicine, often group by random digits table
50 examples.The oral medicine prepared by embodiment 1 of one group of Chinese medicine, decoction to concentration is containing crude drug amount 0.25g/mL, in clean period
Rear daystart medication, until menstrual onset next time is discontinued medication, every day 1 dose, 1 dose is 10mL；One menstrual cycle is one
The course for the treatment of, continuously 3 menstrual cycle for the treatment of.Two groups of Chinese medicine is oral by the Chinese medicine composition of following weight portion: Fructus Liquidambaris 5 parts, king are not
Staying row 15 parts, decocting to concentration is containing crude drug amount 0.25g/mL, and daystart medication after clean period, until menstruation next time
Rising and discontinue medication, every day 1 dose, 1 dose is 10mL；One menstrual cycle is a course for the treatment of, continuously 3 menstrual cycle for the treatment of.Chinese medicine
Three groups oral by the Chinese medicine composition of following weight portion: Fructus Liquidambaris 15 parts, Semen Vaccariae 10 parts, Semen Aesculi 10 parts, decocts to dense
Degree is containing crude drug amount 0.25g/mL, daystart medication after clean period, until menstrual onset next time is discontinued medication, and every day
1 dose, 1 dose is 10mL；One menstrual cycle is a course for the treatment of, continuously 3 menstrual cycle for the treatment of.Three groups all contact treatment 3 months, control
During treatment equal condom contraception, all cases in treatment before first month through the cycle through clean 3-7 days after routine examination is without exception
Row general anesthesia B ultrasonic monitors that lower hysteroscope bilateral salpingo intubates logical liquid art, and second month was examined through routine through clean 3-7 days through the cycle
Looking into rear row HSG without exception to check, after treating 3 months, then row general anesthesia B ultrasonic monitors that descending hysteroscope bilateral salpingo intubates logical
Liquid art and HSG check, before concrete grammar is with treatment.Each group case all follows up a case by regular visits to pregnancy rate half a year.
2 results
2.1 observation index
2.1.1 security inspection
(1) blood, urine, stool routine examination inspection；
(2) Liver and kidney function and Electrocardioscopy；
(3) untoward reaction record at any time occurs.
2.1.2 health giving quality is observed
(1) curative effect index: after treatment general anesthesia B ultrasonic monitor descending hysteroscope bilateral salpingo intubate logical liquid art and
HSG checks that bilateral salpingo improves situation；Treat pregnancy rate in later six months.
(2) secondary efficacy index: before and after treatment, Chinese medicine syndrome integral changes situation；
2.2 the standard of curative effect evaluation
2.2.1 clinical efficacy evaluation
With reference to " new Chinese medicine guideline of clinical investigations ":
(1) recovery from illness: after treatment, bilateral salpingo is unobstructed, out of shape good and treats uterine pregnancy in later six months.
(2) take a turn for the better: general anesthesia B ultrasonic monitors that descending hysteroscope bilateral salpingo intubates logical liquid art and radiography shows at least one
Oviductus lateralis degree of mobility is clearly better before relatively treating；
(3) invalid: general anesthesia B ultrasonic monitors that descending hysteroscope bilateral salpingo intubates logical liquid art and radiography display fallopian tube
Degree of mobility is unchanged or increases the weight of.
2.2.2 TCM syndrome efficacy assessment standard
With reference to " new Chinese medicine guideline of clinical investigations ":
(1) cure: transference cure after treatment, n >=95%；
(2) effective: after treatment, symptom substantially alleviates, 70%≤n ＜ 95%；
(3) effective: after treatment, symptom has alleviated, 30%≤n ＜ 70%；
(4) invalid: after treatment, symptom increases the weight of without substantially alleviating or having, n ＜ 30%.
Note: computing formula (nimodipine method)=[integration before (integration after integration-treatment before treatment)/treatment] × 100%
2.3 statistical procedures methods
Clinical data data uses statistic software SPSS 17.0 that data are carried out statistical analysis.
2.4 Clinical efficacy comparison
Three groups of Disease Clinical comparitive study the results are shown in Table 2, and one group of Chinese medicine is fully recovered 19 examples, and take a turn for the better 29 examples, invalid 2 examples, always has
Efficiency 96.0%；Two groups of Chinese medicine is fully recovered 5 examples, and take a turn for the better 18 examples, invalid 27 examples, total effective rate 46.0；Three groups of Chinese medicine is fully recovered 12 examples, good
Turn 24 examples, invalid 14 examples, total effective rate 72.0%.One group of Chinese medicine is the most effective with two groups of Chinese medicine and three groups of Chinese medicine to be compared, difference
There is statistical significance (P < 0.05).The curative effect of one group of oral medication cold-damp stasis type salpingitic infecundity of Chinese medicine is described
Good.
2 three groups of Disease Clinical comparitive study example (%) of table
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate |
| One group of Chinese medicine | 50 | 19(38.0) | 29(58.0) | 2(4.0) | 96.0 |
| Two groups of Chinese medicine | 50 | 5(10.0) | 18(36.0) | 27(54.0) | 46.0* |
| Three groups of Chinese medicine | 50 | 12(24.0) | 24(48.0) | 14(28.0) | 72.0* |
Note: compare * P < 0.05 with one group of Chinese medicine
TCM syndrome comparitive study before and after 2.5 treatments
Three groups of TCM syndrome comparitive study the results are shown in Table 3, and 9 examples cured by one group of Chinese medicine, effective 17 examples, effective 21 examples, and invalid 3
Example, total effective rate 94.0%；Two groups of Chinese medicine cures 2 examples, effective 14 examples, effective 16 examples, invalid 18 examples, total effective rate 64.0%；
Three groups of Chinese medicine cures 5 examples, effective 16 examples, effective 19 examples, invalid 10 examples, total effective rate 80.0%.One group of Chinese medicine and two groups of Chinese medicine
And three groups of total effective rates of Chinese medicine compare, difference has statistical significance (P < 0.05).Illustrate that one group of Chinese medicine is administered orally and improving symptom
With sign general curative effect aspect, curative effect is better than two groups of Chinese medicine and three groups of Chinese medicine.Result above shows, the Chinese medicine composition of the present invention
Clinical symptoms and the sign of the salpingitic infecundity disease of cold-damp stasis type can be effectively improved, hence it is evident that improve the several of fallopian tube reconstruction
Rate.
TCM syndrome comparitive study example (%) before and after the treatment of 3 three groups of table
| Group | n | Cure | Effective | Effectively | Invalid | Total effective rate |
| One group of Chinese medicine | 50 | 9(18.0) | 17(34.0) | 21(42.0) | 3(6.0) | 94.0 |
| Two groups of Chinese medicine | 50 | 2(4.0) | 14(28.0) | 16(32.0) | 18(36.0) | 64.0* |
| Three groups of Chinese medicine | 50 | 5(10.0) | 16(32.0) | 19(38.0) | 10(20.0) | 80.0* |
Note: compare * P < 0.05 with one group of Chinese medicine
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of without departing from the inventive method, it is also possible to makes some improvement and supplements, and these improve and supplement and also should be regarded as
Protection scope of the present invention.
Claims (8)
1. the Chinese medicine composition treating tubal obstruction barrenness, it is characterised in that described Chinese medicine composition is by following
The crude drug of weight portion is made: Fructus Liquidambaris 2-10 part, Semen Vaccariae 10-20 part, Semen Aesculi 10-20 part.
Treat the Chinese medicine composition of tubal obstruction barrenness the most according to claim 1, it is characterised in that described Chinese drug-treated group
Compound is made up of the crude drug of following weight portion: Fructus Liquidambaris 4-7 part, Semen Vaccariae 13-17 part, Semen Aesculi 13-17 part.
Treat the Chinese medicine composition of tubal obstruction barrenness the most according to claim 1, it is characterised in that described Chinese drug-treated group
Compound is made up of the crude drug of following weight portion: Fructus Liquidambaris 5 parts, Semen Vaccariae 15 parts, Semen Aesculi 15 parts.
4. claim 1-3 arbitrary described Chinese medicine composition application in preparation treatment tubal obstruction barrenness medicine.
Application the most according to claim 4, it is characterised in that described infertility Chinese medical discrimination belongs to cold-damp stasis type.
Application the most according to claim 4, it is characterised in that described medicine adds pharmaceutically acceptable carrier as required
It is prepared as any pharmaceutical dosage form.
Application the most according to claim 4, it is characterised in that described medicine also includes the adjuvant pharmaceutically allowed.
Application the most according to claim 4, it is characterised in that the dosage form of described medicine is capsule, granule, tablet, is administered orally
Liquid, mixture or syrup.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674940A (en) * | 2019-01-16 | 2019-04-26 | 刘莲 | The Chinese medicine and decoction for treating female infertility |
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| CN103948769A (en) * | 2014-04-28 | 2014-07-30 | 青岛市市立医院 | Traditional Chinese medicine for treating infertility caused by uterine tube inflammatory impassability |
| CN105412861A (en) * | 2015-11-27 | 2016-03-23 | 梁苑春 | Traditional Chinese medicine composition for treating tubal nowhere and preparation method thereof |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948769A (en) * | 2014-04-28 | 2014-07-30 | 青岛市市立医院 | Traditional Chinese medicine for treating infertility caused by uterine tube inflammatory impassability |
| CN105412861A (en) * | 2015-11-27 | 2016-03-23 | 梁苑春 | Traditional Chinese medicine composition for treating tubal nowhere and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674940A (en) * | 2019-01-16 | 2019-04-26 | 刘莲 | The Chinese medicine and decoction for treating female infertility |
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