CN116135221A - Wuzi Yichong prescription and preparation and application thereof - Google Patents
Wuzi Yichong prescription and preparation and application thereof Download PDFInfo
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- CN116135221A CN116135221A CN202310422344.0A CN202310422344A CN116135221A CN 116135221 A CN116135221 A CN 116135221A CN 202310422344 A CN202310422344 A CN 202310422344A CN 116135221 A CN116135221 A CN 116135221A
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Abstract
The invention discloses a five-seed healthy-energy formulation which comprises glossy privet fruit, semen cuscutae, motherwort fruit, raspberry, plantain seed, angelica, szechuan lovage rhizome, prepared rehmannia root, white paeony root (wine), nutgrass galingale rhizome (vinegar) and liquorice. The five-ingredient beneficial agent can be added with pharmaceutically acceptable auxiliary materials to prepare a preparation. The five-seed beneficial towards formula and the preparation thereof can be used for preparing medicines for treating infertility.
Description
Technical Field
The invention belongs to the field of medicines, and particularly relates to a pharmaceutical composition for treating infertility, a preparation and application thereof, in particular to a five-ingredient beneficial towards prescription, a preparation and application thereof.
Background
In recent years, infertility has become a global problem affecting both men and women and families, and the incidence rate in women of childbearing age is about 15%. It is generally believed that 80% of women at child bearing age who do not take contraceptive action should be pregnant within 12 months after the wedding, and if the woman is not pregnant one year after the wedding, the possibility of the illness should be considered. The disease is 20% entirely due to men and 30% is associated with couples, so about 50% of the sterility factors can be considered to be related to men. In female infertility, ovulation factors account for about 25-30%. Male infertility belongs to the categories of "no son", "no subsequent" and the like in traditional Chinese medicine, and female infertility is not separately classified in traditional Chinese medicine, so that the male infertility belongs to the category of "infertility" at all, and besides, the male infertility is also scattered among symptoms such as "mass", "metrorrhagia and metrostaxis", "leukorrhagia" and the like.
At present, the incidence rate of infertility is increased, and the infertility becomes a wide social and family problem, and the modern medical treatment method does not have an important breakthrough. Therefore, it is of great importance to develop a pharmaceutical composition which can effectively treat infertility.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition for treating infertility, a preparation and application thereof, in particular to a five-ingredient beneficial brewing formula, a preparation and application thereof. The five-seed healthy energy formulation can be used for treating infertility, in particular infertility caused by disharmony of thoroughfare and conception vessels, deficiency of vital energy in kidneys, deficiency of qi and blood, or anovulatory dysfunctional infertility with blood deficiency and blood stasis.
The invention aims at realizing the following technical scheme:
the five-ingredient Yichong formula comprises the following components in parts by weight: 15-30 parts of glossy privet fruit, 10-30 parts of semen cuscutae, 10-20 parts of motherwort fruit, 10-20 parts of raspberry, 10-20 parts of plantain seed, 10-20 parts of angelica, 10-20 parts of ligusticum wallichii, 10-30 parts of prepared rehmannia root, 10-30 parts of white paeony root (wine) (namely white paeony root prepared by wine), 10-15 parts of nutgrass galingale rhizome (vinegar) (namely nutgrass galingale rhizome prepared by vinegar) and 3-10 parts of liquorice.
Preferably, the five-ingredient beneficial towards formula comprises the following components in parts by weight: 20-30 parts of glossy privet fruit, 15-30 parts of semen cuscutae, 10-18 parts of motherwort fruit, 10-18 parts of raspberry, 10-18 parts of plantain seed, 10-18 parts of angelica, 10-18 parts of ligusticum wallichii, 15-30 parts of prepared rehmannia root, 10-25 parts of white paeony root (wine), 10-15 parts of nutgrass galingale rhizome (vinegar) and 3-10 parts of liquorice.
Preferably, the five-ingredient beneficial towards formula comprises the following components in parts by weight: 25-30 parts of glossy privet fruit, 15-20 parts of semen cuscutae, 10-15 parts of motherwort fruit, 10-15 parts of raspberry, 10-15 parts of plantain seed, 10-18 parts of angelica, 10-15 parts of ligusticum wallichii, 10-20 parts of prepared rehmannia root, 10-20 parts of white paeony root (wine), 10-12 parts of nutgrass galingale rhizome (vinegar) and 3-9 parts of liquorice.
Preferably, the five-ingredient beneficial towards formula further comprises the following components in parts by weight: 10-15 parts of cortex moutan and 6-15 parts of cinnamon.
Preferably, the five-ingredient beneficial towards formula further comprises the following components in parts by weight: 5-10 parts of vinegar bupleurum, 10-15 parts of bighead atractylodes rhizome and 15-30 parts of poria cocos.
Preferably, the five-ingredient beneficial towards formula further comprises the following components in parts by weight: 10-15 parts of fructus psoraleae and 15-30 parts of cornu cervi degelatinatum.
Preferably, the five-ingredient beneficial towards formula further comprises the following components in parts by weight: 9-15 parts of combined spicebush root and 9-15 parts of mugwort leaf.
Preferably, the five-ingredient beneficial towards formula further comprises the following components in parts by weight: 10-20 parts of eclipta, and 3-10 parts of placenta hominis powder.
Preferably, the five-ingredient beneficial towards formula further comprises the following components in parts by weight: 15-30 parts of astragalus membranaceus and 15-30 parts of codonopsis pilosula.
The five-ingredient beneficial formulation can be added with pharmaceutically acceptable auxiliary materials to prepare various preparations such as pills, paste, granules, capsules, tablets, powder, decoction and the like.
The five-seed beneficial towards prescription and the preparation thereof can be used for preparing medicines for treating infertility.
"Huangdi's inner channel: "female seven years old, kidney-qi exuberance, longer teeth; the theory of the kidney qi-Tian Deng-Chong-ren-cell Gong Zhou is an important system for guiding the gynecologic clinical differentiation of traditional Chinese medicine so far; the functional disorder of the genital shaft can cause qi and blood disorder, qi stagnation and blood stasis, damp-heat internal resistance, and is a main cause of female infertility. From the modern medical point of view, the female reproductive system has periodical changes, and hypothalamus, pituitary gland and ovaries are mutually regulated and restrained, which is the core of female reproductive endocrine and is called hypothalamus-pituitary-ovaries axis. Infertility caused by ovulation failure is mainly caused by hypothalamic-pituitary-ovary axis dysfunction.
According to years of clinical practice experience, the inventor of the application considers that the deficiency of the vital energy in the kidney is a basic pathogenesis of infertility caused by ovulation disorder, and the deficiency of the vital energy further derives pathological products such as blood stasis, phlegm dampness and the like, and the five-seed tonifying formula provided by the invention is used for treating infertility aiming at the pathogenesis of the diseases and has good clinical curative effects.
In the recipe, glossy privet fruit: sweet, bitter and cool. It enters liver and kidney meridians. Efficacy: nourishing liver and kidney, wu Xuming mesh. Shennong Ben Cao Jing (Shennong's herbal): the main functions of tonifying middle-jiao, soothing five viscera, nourishing spirit and removing diseases. The fertilizer is taken for a long time. "
Semen cuscutae: sweet and warm. It enters liver, kidney and spleen meridians. Efficacy: tonify liver and kidney, arrest spontaneous emission, reduce urination, improve eyesight, stop diarrhea, quench thirst and prevent abortion. Shennong Ben Cao Jing (Shennong's herbal): the main body is damaged, the deficiency is compensated, the strength is improved, and the health is improved. .. it is administered for a long time to improve eyesight, lighten weight and prolong life. "
Motherwort fruit: sweet and pungent, slightly cold in nature. Enter liver meridian. Efficacy: promoting blood circulation, regulating menstruation, removing liver heat, and improving eyesight.
Raspberry fruit: sweet, sour, slightly warm. It enters liver, kidney and bladder meridians. Efficacy: kidney-tonifying, essence-securing, urination-reducing and eyesight-improving. Materia medica description: the recipe of Rubi fructus can be used for treating fatigue and consumptive disease, or tonifying kidney yang, or tonifying kidney yin qi, or nourishing essence and blood, and it is also reasonable that the recipe is suitable for its principal aspects. "
Semen plantaginis: sweet and slightly cold. Enter liver, kidney, lung and small intestine meridians. Efficacy: clearing heat and promoting urination, promoting digestion and treating stranguria, clearing liver and improving vision, clearing lung and resolving phlegm. Famous physicians' miscellaneous records: in the male injury, the women have the advantages of leaching, not wanting to eat, nourishing lung, strengthening yin, replenishing essence, improving eyesight and treating red pain. "
Chinese angelica root: sweet, pungent and warm. It enters liver, heart and spleen meridians. Efficacy: replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation.
White peony root: bitter, sour, sweet and slightly cold. Enter liver and spleen meridians. Efficacy: nourishing blood, regulating menstruation, calming liver, relieving pain, astringing yin and stopping sweating. Shennong Ben Cao Jing (Shennong's herbal): abdominal pain due to pathogenic qi, removing blood obstruction, resolving hard mass, treating cold and heat hernia, relieving pain, promoting urination and invigorating qi. "
Prepared rehmannia root: sweet and slightly warm. It enters liver and kidney meridians. Efficacy: replenishing blood, nourishing yin, replenishing essence and replenishing marrow.
Ligusticum wallichii: pungent and warm. Enter liver, gallbladder and pericardium meridians. Efficacy: promoting blood circulation, activating qi-flowing, dispelling pathogenic wind and relieving pain. Shennong Ben Cao Jing (Shennong's herbal): mainly treating apoplexy with the symptoms of cerebral infarction, headache, cold arthralgia, spasm of tendons, gold wound, and blood obstruction of women. "
And (3) rhizoma cyperi: pungent, slightly bitter, slightly sweet, and flat. It enters liver, spleen and triple energizer meridians. Efficacy: promoting qi circulation, resolving stagnation, regulating menstruation, relieving pain and detumescence. Compendium of materia Medica: the nutgrass galingale rhizome has the advantages of smooth qi, no cold, fragrant and fleeing, and has the advantages of being more pungent and energy-dissipating, slightly bitter and descending, slightly sweet and mild. The raw materials go upward to the chest and diaphragm, reach the skin externally, travel downward to the liver and kidney, and travel through the waist and feet externally. .. the general name of the disease is general, and the general name of the women is also general. "
Licorice root: sweet and flat. It enters heart, lung, spleen and stomach meridians. Efficacy: tonify qi and tonify middle energizer, clear heat and detoxify, dispel phlegm and relieve cough, relieve spasm and alleviate pain, and harmonize drug properties.
The invention discloses a five-fruit healthy-energy formulation, which takes glossy privet fruit, semen cuscutae, motherwort fruit, raspberry and plantain seed as monarch drugs, is characterized in that medlar and shizandra berry which are more greasy and are not left are deleted on the basis of a five-fruit healthy-energy pill in the original classical prescription, and motherwort fruit and glossy privet fruit which are directly entering liver and kidney channels are newly added, wherein the five-fruit healthy-energy formulation enables the brewing Ren Gu to take effect, and the upper and lower part of the healthy energy is normal, and the menstruation and the pregnancy are normal, so the formulation is monarch. The Chinese angelica, the ligusticum wallichii, the prepared rehmannia root and the white paeony root are taken as ministerial drugs, so that the effects of regulating qi and blood, infiltrating irrigation of the thoroughfare and conception vessels are enhanced, the effects of nourishing blood and softening liver are enhanced when the thoroughfare and conception vessels are regulated, the qi and blood are smooth, and the Chinese medicinal herbs are stored and discharged. Rhizoma Cyperi is an qi-flowing herb in blood, and is an adjuvant drug for assisting the rotation of qi, blood and yin and yang to promote the circulation of qi and blood. So that liquorice is used for harmonizing various medicines. The whole formula has the effects of tonifying thoroughfare and conception vessels, filling essence and qi, nourishing blood and softening liver. So as to enable the middle-jiao to be gasified, the pivot machine is operated, and the blood sea is full, so that the stomach is regulated and then is further regulated.
In clinical applications, prescriptions can also be adjusted and modified for different situations of patients, for example:
(1) For patients with premenstrual irritability and lower abdomen crymodynia, folium Artemisiae Argyi and radix Linderae can be added.
(2) For uterine dysplasia, ecliptae herba and placenta hominis powder may be added.
(3) Radix astragali and radix Codonopsis may be added for relieving fatigue and debilitation.
(4) If hysteromyoma exists, bulbus Fritillariae Thunbergii, semen Persicae, and cortex moutan can be added.
(5) Cortex moutan, cortex Cinnamomi, and rhizoma corydalis can be added if the abdominal pain is obvious.
(6) If breast nodule is complicated, semen Citri Tangerinae, semen litchi and cortex Albizziae can be added.
Compared with the prior art, the invention has the beneficial effects that:
1. the five-seed Yichong prescription has the functions of tonifying Chong and ren meridians, filling essence and qi, nourishing blood and softening liver, and can enable middle-jiao qi to move, a pivot machine to operate, and blood sea fullness to be regulated.
2. The five-seed Yichong prescription is used for treating infertility, and particularly has good curative effect on infertility caused by thoroughfare and conception vessel disharmony, deficiency of vital essence and qi in the kidney, deficiency of qi and blood, or ovulation disorder infertility accompanied by blood deficiency and blood stasis.
3. The five-seed healthy energy formulation has good curative effect, no side effect, good taste and convenient administration, and can be widely accepted by patients.
Description of the embodiments
The present invention will be further described with reference to examples, but the present invention is not limited to the examples.
Example 1
A five-ingredient Yichong formula comprises the following components: 15g of glossy privet fruit, 10g of semen cuscutae, 10g of motherwort fruit, 10g of raspberry, 10g of plantain seed, 10g of angelica, 10g of ligusticum wallichii, 10g of prepared rehmannia root, 10g of white paeony root (wine), 10g of nutgrass galingale rhizome (vinegar) and 3g of liquorice.
Example 2
A five-ingredient Yichong formula comprises the following components: 30g of glossy privet fruit, 30g of semen cuscutae, 20g of motherwort fruit, 20g of raspberry, 20g of plantain seed, 20g of angelica, 20g of ligusticum wallichii, 30g of prepared rehmannia root, 30g of white paeony root (wine), 15g of nutgrass galingale rhizome (vinegar) and 10g of liquorice.
Example 3
A five-ingredient Yichong formula comprises the following components: 18g of glossy privet fruit, 15g of semen cuscutae, 12g of motherwort fruit, 10g of raspberry, 10g of plantain seed, 15g of angelica, 10g of ligusticum wallichii, 15g of prepared rehmannia root, 15g of white paeony root (wine), 10g of nutgrass galingale rhizome (vinegar) and 3g of liquorice.
Example 4
A five-ingredient Yichong formula comprises the following components: 20g of glossy privet fruit, 15g of semen cuscutae, 15g of motherwort fruit, 15g of raspberry, 10g of plantain seed, 18g of angelica, 10g of ligusticum wallichii, 20g of prepared rehmannia root, 15g of white peony root (wine), 12g of nutgrass galingale rhizome (vinegar) and 6g of liquorice.
Example 5
A five-ingredient Yichong formula comprises the following components: 25g of glossy privet fruit, 20g of semen cuscutae, 15g of motherwort fruit, 20g of raspberry, 15g of plantain seed, 18g of angelica, 15g of ligusticum wallichii, 20g of prepared rehmannia root, 20g of white peony root (wine), 15g of nutgrass galingale rhizome (vinegar) and 9g of liquorice.
Example 6
A five-ingredient Yichong formula comprises the following components: 30g of glossy privet fruit, 20g of semen cuscutae, 20g of motherwort fruit, 20g of raspberry, 20g of plantain seed, 20g of angelica, 15g of ligusticum wallichii, 20g of prepared rehmannia root, 20g of white paeony root (wine), 15g of nutgrass galingale rhizome (vinegar) and 9g of liquorice.
Example 7
A five-ingredient Yichong formula comprises the following components: 30g of glossy privet fruit, 30g of semen cuscutae, 20g of motherwort fruit, 20g of raspberry, 15g of plantain seed, 20g of angelica, 15g of ligusticum wallichii, 30g of prepared rehmannia root, 30g of white paeony root (wine), 15g of nutgrass galingale rhizome (vinegar) and 10g of liquorice.
Example 8
A five-ingredient Yichong formula comprises the following components: 15g of glossy privet fruit, 25g of semen cuscutae, 18g of motherwort fruit, 18g of raspberry, 18g of plantain seed, 12g of angelica, 18g of ligusticum wallichii, 25g of prepared rehmannia root, 25g of white paeony root (wine), 13g of nutgrass galingale rhizome (vinegar) and 5g of liquorice.
Example 9
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: cortex moutan 10g and cortex Cinnamomi 6g.
Example 10
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: cortex moutan 10g and cortex Cinnamomi 15g.
Example 11
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: cortex moutan 15g and cortex Cinnamomi 6g.
Example 12
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 5g of vinegar bupleurum, 15g of bighead atractylodes rhizome and 15g of poria cocos.
Example 13
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 6g of vinegar bupleurum, 12g of bighead atractylodes rhizome and 25g of poria cocos.
Example 14
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 10g of vinegar bupleurum, 10g of bighead atractylodes rhizome and 30g of poria cocos.
Example 15
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 10g of fructus psoraleae and 30g of cornu cervi degelatinatum.
Example 16
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 15g of fructus psoraleae and 20g of cornu cervi degelatinatum.
Example 17
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 15g of fructus psoraleae and 15g of cornu cervi degelatinatum.
Example 18
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 10g of combined spicebush root and 10g of mugwort leaf.
Example 19
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 9g of combined spicebush root and 15g of mugwort leaf.
Example 20
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 15g of eclipta and 3g of placenta hominis powder.
Example 21
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 20g of eclipta and 10g of placenta hominis powder.
Example 22
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 15g of astragalus root and 25g of pilose asiabell root.
Example 23
The five-ingredient beneficial punch formulation according to any one of embodiments 1 to 8, further comprising: 30g of astragalus root and 20g of pilose asiabell root.
Example 24
A preparation of WUZIYICHONG formulation is prepared by weighing medicinal materials according to any one of examples 1-23, soaking in water, decocting twice, mixing decoctions, filtering, concentrating to soft extract, drying, pulverizing into fine powder, adding dextrin, starch or other appropriate adjuvants, mixing, and making into tablet, powder, etc.
Example 25
A pill of five-seed Yichong formula is prepared by weighing medicinal materials according to the formula of any one of examples 1-8 and preparing the pill according to the following steps:
(1) Pulverizing fructus Ligustri Lucidi, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, rhizoma Cyperi (vinegar), and Glycyrrhrizae radix into fine powder;
(2) Decocting the rest materials with water for 3 times each for 1.5 hr, filtering, mixing filtrates, concentrating under reduced pressure to obtain soft extract with relative density of 1.25-1.30 (60deg.C), adding the fine powder of the five medicinal materials prepared in step (1), mixing, drying, pulverizing into fine powder, sieving, and mixing;
(3) Adding 30-40 g refined honey and proper amount of water into each 100g medicinal powder, making into pill, drying, polishing, and making into pill.
Application example-the preparation of the five-seed Yichong prescription of the invention is used for clinical observation of infertility treatment.
1. Purpose of investigation
The clinical curative effect and adverse reaction of the five-seed beneficial flushing prescription for treating the infertility caused by ovulation failure are observed.
2. Research method
120 patients meeting the inclusion standard and not meeting the exclusion standard of infertility in recent five years are selected, and the clinical curative effect and adverse reaction of the patients are observed by applying the pharmaceutical composition of the invention to treat one course of treatment.
3. Study object
Female infertility is defined as primary infertility that occurs in women and women living for more than 1 year after marriage, and female infertility that occurs in female and women with normal reproductive function, no contraception and no conception, and secondary infertility that occurs after birth or after birth and no contraception and no conception occurs for more than 1 year. All cases exclude organic lesions of the hypothalamus and pituitary.
Western medicine diagnosis standard
Infertility diagnosis is formulated with reference to "gynaecology and obstetrics science": married couples with normal sexual life, with non-contraception and non-conception patients living for two or more years.
(II) criteria for diagnosis of Chinese medical science symptoms
The infertility and kidney essence deficiency syndrome is formulated by referring to the Chinese medicine New medicine clinical research guidelines.
(1) Main symptoms are as follows: (1) infertility for wedding; (2) menstrual disorder.
(2) Secondary symptoms: (1) a dull complexion or flushing of the cheeks; (2) dizziness, tinnitus, soreness of waist and legs; (3) apathy; (4) clear urine, little urine, yellow urine, loose stool or dry stool; (5) a pale and dark tongue with white coating or a red and little coating and a deep and thready pulse.
The main symptoms are more than three symptoms, and the secondary symptoms can be diagnosed.
(III) criteria for diagnosis of infertility due to ovulation dysfunction
The related standards of the infertility caused by ovulation disorder are formulated by referring to the guidelines of clinical research on new Chinese medicine, and the ovulation disorder is divided into two major categories of anovulation and luteal phase disorder.
(1) Diagnostic criteria for infertility caused by anovulation: (1) the basal body temperature is continuously recorded for more than 3 months in a single phase; (2) the vaginal abscission cell smear examination has no periodic change; (3) examination of cervical mucus crystallization showed no ellipsoids; (4) endometrium examination 6 days before menstruation has no typical secretion phase change; (5) monitoring for anovulatory signs by series of B-ultrasound; (6) blood, urinary progesterone levels are lower than luteal phase levels. Of the above 6, those with 2 were diagnosed as anovulatory.
(2) Diagnostic criteria for infertility due to luteal phase failure: (1) base body temperature biphasic, but with atypical or less than 12 days post-elevation; (2) premenstrual endometrium shows secretory phase change, but differs from the response date of normal menstrual cycle by more than 2 days; (3) b ultrasonic imaging of the ovaries in the luteal phase shows that the ovaries are marked by the corpus luteum and are sterile; (4) 6 days after ovulation, the amount of the urinary pregnane diol is less than 5mg/24h, or the amount of the serum progesterone is twice less than 10mg/mL. The above 4 items have 2 items, and can be used for diagnosis in combination with clinic.
(IV) inclusion criteria
Meets western medicine diagnosis standard, traditional Chinese medicine syndrome diagnosis standard and ovulation disorder infertility standard, and has an age of 22-45 years.
(fifth) exclusion criteria
(1) Infertility due to congenital physiological defects or deformities. (2) infertility due to genetic factors. (3) The examination proves that endometriosis, myometrium disease, hysteromyoma and uterine dysplasia are caused. (4) abnormal reproductive function of men. (5) those under 22 years of age or over 45 years of age. (6) Patients with serious primary diseases such as cardiovascular diseases, liver diseases, renal diseases, hematopoietic diseases, etc., and mental diseases. (7) allergic patients to the study drug. (8) failing to meet the inclusion criteria. The treatment effect or the safety can not be judged if the medicine is not administered according to the regulations, and the treatment effect or the incomplete data can not be judged.
4. Therapeutic method
Therapeutic drug: the invention relates to a five-seed beneficial towards prescription and a preparation.
The administration method comprises the following steps: all started to treat on menstrual 7, and taken 2 times a day, 2 days per dose; the continuous 14 days are 1 period, and the treatment period is 1 course of treatment for 6 periods, namely about 6 months.
5. Efficacy evaluation criteria
And (3) curing: pregnant women within half a year after treatment;
the effect is shown: after the treatment is finished, the menstruation of the patient is normal, the BBT of the patient is presented in a bidirectional curve, and the B ultrasonic examination shows growth dominant follicles;
the method is effective: after the treatment is finished, the menstrual cycle of the patient is recovered to be normal, the menstrual quantity is small, the LH peak in urine can be detected in the ovulatory period, or the mature follicle is detected by B ultrasonic, BBT detection shows a typical biphasic curve, and the E and P values are normal;
invalidation: after the end of treatment, the patient had no improvement in clinical symptoms or signs as compared to before treatment.
6. Test results
Group of people to be tested
The study investigated a total of 120 cases, 102 of which were effective. 59 cases of primary infertility and 43 cases of secondary infertility. 35 cases of age 22-30 years old, 40 cases of age 30-35 years old, 18 cases of age 36-40 years old, and 9 cases of age 41-45 years old. 102 patients underwent gynecological examination: 92 cases of the patients with normal uterus size, 8 cases of the patients with uterine dysplasia and 2 cases of the patients with hysteromyoma. 84 cases for normal menstruation and 18 cases for irregular menstruation. 43 patients with secondary infertility are hysteroscopic, 29 patients with bilateral oviduct obstruction, 12 patients with no obstruction and 2 patients with bilateral oviduct obstruction. The disease course is shortest 2 years, and longest 10 years, wherein 36 cases are 2 years old, 28 cases are 3 years old, 18 cases are 4 years old, 9 cases are 5 years old, and 11 cases are more than 6 years old in 102 cases.
(II) therapeutic effects
120 cases of infertility patients with ovulation failure are taken together, wherein 11 cases of infertility patients with ovulation failure automatically withdraw from treatment, 3 cases of infertility patients with post-administration physical discomfort withdraw from treatment, and 4 cases of infertility patients with ovulation failure leave from treatment. Of 102 cases of effective cases, 65 cases of anovulatory infertility, and 37 cases of anovulatory patients and luteal phase-defect patients.
1. Pregnancy rate
102 cases of infertility patients with ovulation failure were pregnant within half a year after treatment.
2. Curative effect
Of 102 cases of infertility caused by ovulation failure, 22 cases (21.6%) of pregnant patients, 33 cases (32.4%) of the patients were observed, 19 cases (18.5%) of the patients were observed, and 28 cases (27.5%) of the patients were observed. After the treatment is finished, the total effective rate of the treatment of 102 patients is 72.5 percent. See table 1.
(III) analysis of the Effect of Combined administration
No combined medication is used, and other medicines are stopped during the treatment period.
(IV) Security
Out of 120 cases of infertility caused by ovulation disorder, 3 cases of infertility caused by ovulation disorder were treated with withdrawal from treatment (slight diarrhea occurred after two cases of infertility were treated), and nausea occurred in one case), without other adverse reactions.
7. Case of cases
1. Patient Li Mou, female, 34 years old, did not contraception for 1 year infertility. The menstrual cycle is 35 days, the quantity is less, the color is dark, the menstrual cycle has blocks, and the menstrual cycle is clean for 7 days. The pain of the breast before menstruation, waist soreness during menstruation, plain without special discomfort. Pale tongue with white coating and deep and thready pulse. B ultrasonic shows: the uterine accessory has no obvious abnormality. Six items: normal. History of fertility: 1-0-0-1.
The five-ingredient Yichong formula used in the case is as follows: 30g of glossy privet fruit, 30g of semen cuscutae, 20g of motherwort fruit, 20g of raspberry, 20g of plantain seed, 20g of angelica, 20g of ligusticum wallichii, 30g of prepared rehmannia root, 30g of white peony root (wine), 15g of nutgrass galingale rhizome (vinegar), 10g of cortex moutan, 15g of cinnamon and 10g of liquorice. A pill prepared according to the preparation method described in example 25.
After a period of treatment, the menstrual cycle is 30 days, the dosage is moderate, the color is red, and the menstrual cycle is clean for 7 days. Pain in the breast before menstruation, soreness of waist during menstruation is relieved. Pregnancy succeeded one month after drug withdrawal.
2. Patient Wang Mou, female, 27 years old, did not contraception for 1 year infertility. Menstrual cycle 40 days, less quantity, dark color, block and clean for 5 days. Without dysmenorrhea. Plain waist soreness, dizziness, cold feeling, normal diet and shit. Pale tongue with white coating and deep and thready pulse. Once ovulation was detected by B-ultrasound, the follicles were unable to mature. History of fertility: 0-0-0-0.
The five-ingredient Yichong formula used in the case is as follows: 18g of glossy privet fruit, 15g of semen cuscutae, 12g of motherwort fruit, 10g of raspberry, 10g of plantain seed, 15g of angelica, 10g of ligusticum wallichii, 15g of prepared rehmannia root, 15g of white paeony root (wine), 10g of nutgrass galingale rhizome (vinegar), 10g of combined spicebush root, 10g of mugwort leaf and 3g of liquorice. A pill prepared according to the preparation method described in example 25.
After a period of treatment, the menstrual cycle is 30 days, the dosage is moderate, the color is red, and the menstrual cycle is clean for 5 days. Soreness of waist and dizziness are alleviated. The pregnancy was successful after 1 month of drug withdrawal.
3. Patient Chen Mou, female, age 30, did not contraception for 2 years. The menstrual cycle is 28 days, the dosage is less, the color is red, and the menstrual cycle is clean for 5 days. Plain waist is sour, easy to diarrhea and less in sodium. Pale tongue with white coating and deep and thready pulse. B ultrasonic: bisoophoric polycystic changes. Six sexual phases are normal.
The five-ingredient Yichong formula used in the case is as follows: 25g of glossy privet fruit, 20g of semen cuscutae, 15g of motherwort fruit, 20g of raspberry, 15g of plantain seed, 18g of angelica, 15g of ligusticum wallichii, 20g of prepared rehmannia root, 20g of white paeony root (wine), 15g of nutgrass galingale rhizome (vinegar), 15g of fructus psoraleae, 20g of cornu cervi degelatinatum and 9g of liquorice. A pill prepared according to the preparation method described in example 25.
After a period of treatment, the patient takes the medicine, diarrhea and anorexia are relieved. B ultrasonic shows: the uterine accessory has no obvious abnormality. And stopping taking the medicine for 2 months to successfully pregnancy.
Patient Luo Mou, female, age 29, did not contraception for 1 year. The menstrual cycle is 37 days, the amount is more, the menstrual cycle has blocks, and the menstrual cycle is clean for 7 days. Plain hypodynamia and lassitude. The medicine can be used for improving sleep and regulating urine. A pale tongue with a thin and white coating. The pulse is deep and thready. History of fertility: 0-0-1-0. B ultrasonic monitoring was performed to detect follicular dysplasia.
The five-ingredient Yichong formula used in the case is as follows: 30g of glossy privet fruit, 30g of semen cuscutae, 20g of motherwort fruit, 20g of raspberry, 20g of plantain seed, 20g of angelica, 20g of ligusticum wallichii, 30g of prepared rehmannia root, 30g of white paeony root (wine), 15g of nutgrass galingale rhizome (vinegar), 30g of astragalus root, 20g of radix codonopsis pilosulae and 10g of liquorice. A pill prepared according to the preparation method described in example 25.
After a period of treatment, the menstrual cycle is 35 days, the dosage is moderate, the color is red, and the menstrual cycle is clean for 7 days. The fatigue and hypodynamia are relieved. Pregnancy was successful two months after drug withdrawal.
Patient Zhao Mou, female, age 40, did not contraception for 1 year. Plain menstrual cycle 28 days, moderate amount, red color, and clean 5 days. It can be used for sleeping normally without special discomfort. History of fertility: 0-0-1-0. The correlation check is free of anomalies.
The five-ingredient Yichong formula used in the case is as follows: example 21 glossy privet fruit 30g, dodder seed 30g, motherwort fruit 20g, raspberry 20g, plantain seed 20g, angelica 20g, ligusticum wallichii 20g, prepared rehmannia root 30g, white peony root (wine) 30g, nutgrass galingale rhizome (vinegar) 15g, eclipta 20g, human placenta powder 10g and licorice root 10g. A pill prepared according to the preparation method described in example 25.
After a period of treatment, the menstrual cycle is 28 days, the dosage is moderate, the color is red, and the menstrual cycle is clean for 5 days. And after stopping taking the medicine, the pregnant woman is successfully pregnant in March.
6. Patient Wu Mou, female, 24 years old, did not contraception for 1 year infertility. The menstrual cycle is 23 days, the amount is less, the color is dark red, the menstrual cycle is clean for 5 days, and the waist is sour and leg sour. A pale and dull tongue with white coating; the pulse is deep and thready. History of fertility: 0-0-0-0.B ultrasonic display: the uterine accessory has no obvious abnormality.
The five-ingredient Yichong formula used in the case is as follows: 18g of glossy privet fruit, 15g of semen cuscutae, 12g of motherwort fruit, 10g of raspberry, 10g of plantain seed, 15g of angelica, 10g of ligusticum wallichii, 15g of prepared rehmannia root, 15g of white paeony root (wine), 10g of nutgrass galingale rhizome (vinegar) and 3g of liquorice. A pill prepared according to the preparation method described in example 25.
After a treatment course, the patient successfully gets pregnant one month after stopping taking the medicine.
Cold, female, 27 years old, is not contraceptively for 1 year. The menstrual cycle of plain menstruation is 40 days, the dosage is less, the menstrual cycle is clean for 5 days, premenstrual irritability, and menstruation waist soreness and leg weakness.
The five-ingredient Yichong formula used in the case is as follows: 30g of glossy privet fruit, 30g of semen cuscutae, 20g of motherwort fruit, 20g of raspberry, 20g of plantain seed, 20g of angelica, 20g of ligusticum wallichii, 30g of prepared rehmannia root, 30g of white paeony root (wine), 15g of nutgrass galingale rhizome (vinegar) and 10g of liquorice. A pill prepared according to the preparation method described in example 25.
After a treatment course, the patient successfully gets pregnant one month after stopping taking the medicine.
The above cases are only part of clinical observation cases, the five-ingredient beneficial prescription is only part of the cases, and in actual clinical use, the dosage of specific medicines in the prescription can be arbitrarily selected within the scope of the invention according to different clinical symptoms of patients.
Claims (10)
1. The five-seed beneficial towards prescription is characterized by comprising the following components in parts by weight: 15-30 parts of glossy privet fruit, 10-30 parts of semen cuscutae, 10-20 parts of motherwort fruit, 10-20 parts of raspberry, 10-20 parts of plantain seed, 10-20 parts of angelica, 10-20 parts of ligusticum wallichii, 10-30 parts of prepared rehmannia root, 10-30 parts of white paeony root processed with wine, 10-15 parts of rhizoma cyperi processed with vinegar and 3-10 parts of liquorice.
2. The five-ingredient healthy instant noodles as claimed in claim 1 further comprise the following components in parts by weight: 10-15 parts of cortex moutan and 6-15 parts of cinnamon.
3. The five-ingredient healthy instant noodles as claimed in claim 1 further comprise the following components in parts by weight: 5-10 parts of vinegar bupleurum, 10-15 parts of bighead atractylodes rhizome and 15-30 parts of poria cocos.
4. The five-ingredient healthy instant noodles as claimed in claim 1 further comprise the following components in parts by weight: 10-15 parts of fructus psoraleae and 15-30 parts of cornu cervi degelatinatum.
5. The five-ingredient healthy instant noodles as claimed in claim 1 further comprise the following components in parts by weight: 9-15 parts of combined spicebush root and 9-15 parts of mugwort leaf.
6. The five-ingredient healthy instant noodles as claimed in claim 1 further comprise the following components in parts by weight: 10-20 parts of eclipta, and 3-10 parts of placenta hominis powder.
7. The five-ingredient healthy instant noodles as claimed in claim 1 further comprise the following components in parts by weight: 15-30 parts of astragalus membranaceus and 15-30 parts of codonopsis pilosula.
8. The formulation of any one of claims 1 to 7, wherein the formulation is prepared from the formulation by adding pharmaceutically acceptable excipients.
9. The use of the wuzi yichong formulation of any of claims 1 to 7 for the preparation of a medicament for the treatment of female infertility.
10. The use of the formulation of the wuziyichong formulation of claim 8, wherein the formulation of the wuziyichong formulation is useful for the manufacture of a medicament for the treatment of female infertility.
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