CN106421200A - Traditional Chinese medicine composition for curing infertility - Google Patents
Traditional Chinese medicine composition for curing infertility Download PDFInfo
- Publication number
- CN106421200A CN106421200A CN201611024078.2A CN201611024078A CN106421200A CN 106421200 A CN106421200 A CN 106421200A CN 201611024078 A CN201611024078 A CN 201611024078A CN 106421200 A CN106421200 A CN 106421200A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- extractum
- radix
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 78
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 208000000509 infertility Diseases 0.000 title claims abstract description 15
- 230000036512 infertility Effects 0.000 title claims abstract description 15
- 231100000535 infertility Toxicity 0.000 title claims abstract description 15
- 210000003056 antler Anatomy 0.000 claims abstract description 13
- 210000002826 placenta Anatomy 0.000 claims abstract description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 229940079593 drug Drugs 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 17
- 239000000243 solution Substances 0.000 claims description 16
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 13
- 210000000582 semen Anatomy 0.000 claims description 13
- 239000003937 drug carrier Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 9
- -1 patch Substances 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000013543 active substance Substances 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000002674 ointment Substances 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000012567 medical material Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000011505 plaster Substances 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 235000008708 Morus alba Nutrition 0.000 claims 1
- 240000000249 Morus alba Species 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 235000008216 herbs Nutrition 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 240000006766 Cornus mas Species 0.000 abstract 1
- 244000124209 Crocus sativus Species 0.000 abstract 1
- 235000015655 Crocus sativus Nutrition 0.000 abstract 1
- 241000110637 Cuscuta chinensis Species 0.000 abstract 1
- 244000286838 Eclipta prostrata Species 0.000 abstract 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 241000208688 Eucommia Species 0.000 abstract 1
- 241000096284 Gynochthodes officinalis Species 0.000 abstract 1
- 241000830535 Ligustrum lucidum Species 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 235000011034 Rubus glaucus Nutrition 0.000 abstract 1
- 244000235659 Rubus idaeus Species 0.000 abstract 1
- 235000009122 Rubus idaeus Nutrition 0.000 abstract 1
- 240000001638 Scurrula parasitica Species 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 description 19
- 230000005906 menstruation Effects 0.000 description 16
- 208000002193 Pain Diseases 0.000 description 13
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 12
- 210000001015 abdomen Anatomy 0.000 description 11
- 230000001105 regulatory effect Effects 0.000 description 9
- 238000010792 warming Methods 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 7
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 230000035935 pregnancy Effects 0.000 description 6
- 208000019255 Menstrual disease Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 230000003821 menstrual periods Effects 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000008967 Enuresis Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 230000003111 delayed effect Effects 0.000 description 3
- 229940011871 estrogen Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 208000021267 infertility disease Diseases 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 210000004291 uterus Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010009866 Cold sweat Diseases 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 206010057071 Rectal tenesmus Diseases 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 210000004696 endometrium Anatomy 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000000745 gonadal hormone Substances 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- ADKOXSOCTOWDOP-UHFFFAOYSA-L magnesium;aluminum;dihydroxide;trihydrate Chemical compound O.O.O.[OH-].[OH-].[Mg+2].[Al] ADKOXSOCTOWDOP-UHFFFAOYSA-L 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 210000004914 menses Anatomy 0.000 description 2
- 239000000583 progesterone congener Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000008093 supporting effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 208000012271 tenesmus Diseases 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- PYTMYKVIJXPNBD-OQKDUQJOSA-N 2-[4-[(z)-2-chloro-1,2-diphenylethenyl]phenoxy]-n,n-diethylethanamine;hydron;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1=CC(OCCN(CC)CC)=CC=C1C(\C=1C=CC=CC=1)=C(/Cl)C1=CC=CC=C1 PYTMYKVIJXPNBD-OQKDUQJOSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 208000037853 Abnormal uterine bleeding Diseases 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002368 Anger Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 206010018092 Generalised oedema Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 206010024419 Libido decreased Diseases 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 208000024783 anasarca Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 1
- 229960002802 bromocriptine Drugs 0.000 description 1
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000007766 cera flava Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 229960004407 chorionic gonadotrophin Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 201000003511 ectopic pregnancy Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008217 follicular development Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000000938 luteal effect Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 208000007106 menorrhagia Diseases 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
- 235000006109 methionine Nutrition 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 206010029446 nocturia Diseases 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 150000003376 silicon Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- ZAVXXBAIPSQJGS-UHFFFAOYSA-B tetracalcium;tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O.[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O.[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O ZAVXXBAIPSQJGS-UHFFFAOYSA-B 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 210000000685 uterine artery Anatomy 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine composition for curing infertility. The traditional Chinese medicine composition is prepared by taking herbs of an antler tablet, human placenta, saffron crocus, a pulp of dogwood fruit, cuscuta chinensis, eucommia, morinda officinalis, fructus psoraleae, epimedium, glossy privet fruit, eclipta alba, loranthus parasiticus, angelica sinensis, parched white peony root, prepared rehmannia root,raspberry and the like as the bulk pharmaceutical chemicals.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly to a kind of Chinese medicine treating infertility, it is by piece of antler, Zi He
Car, Stigma Croci, Fructus Corni, Semen Cuscutae, the Cortex Eucommiae, Radix Morindae Officinaliss, Fructus Psoraleae, Herba Epimedii, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Taxilli, Radix Angelicae Sinensis,
The Chinese medicines such as Radix Paeoniae Alba (parched), Radix Rehmanniae Preparata, Fructus Rubi are prepared from for crude drug.
Background technology
Infertility (infertility) means that all Mr. and Mrs after marriage have normal sexual life, do not practise contraception, live together 2 years and be not subject to
A kind of pregnant disease.
The method of existing treatment infertility mainly includes pharmacotherapy, and key agents have bromocriptine, Chloramiphene, urine rush property
Plain (HMG), chorionic gonadotrophin (HCG), prednisone etc., Chinese medicine then has the female ball of training, spirit of preventing miscarriage etc..
In recent years, going deep into clinical research, market also the Chinese medicine preparation of some treatment infertility occurs, but existing
Medicine belongs to a bit cures the symptoms, not the disease, and some use expensive composition, and some are in application process because uncertain therapeutic efficacy is cut
And interrupt using.
In order to preferably excavate elite in traditional Chinese medical science department of obstetrics and gynecology ancient books, it is modern Chinese medicine department of obstetrics and gynecology clinical service, inventor's warp
Obtain a kind of the kidney warming regulating menstruation and assisting pregnancy ball prescription after research for many years, the work(such as the party has warming the kidney to activate YANG, YIN nourishing adjusts blood, warm palace gravidity assisting
Effect, cures mainly the blood deficiency stagnation of QI, irregular menstruation, leucorrhea with red and white discharge, cold uterus, fails to be impregnated for a long time, inadequate luteal function, adjustment estrogen and progestogen
Deng disease.The present invention overcomes other prescriptions to treat the unicity of infertility type, from organic conception, with traditional Chinese medical science differential diagnosis of diseases with dialectical
Based on, project and embody Clinical Treatment Thoughts Based on Syndrome Differentiation, prescription Chinese crude drug fine powder or medicinal substances extract are added suitable bonding adjuvant and makes ball
Agent.
Clinic thinks, with Chinese medicine to improve estrogen and progestogen level in body, to follicle grow up and inner membrance thickness have substantially
Improvement, and also have the effect of regulating menstruation induced ovulation, can increase and obtain ovum number and improve Clinical Pregnancy Rate in；The sun of the present invention rises blood
The long, rule for the treatment of of regulating menstruation and assisting pregnancy, makes body reach equilibrium between yin and yang, QI and blood is smooth, function is coordinated, and can be obviously improved facing of patient
Bed symptom and tcm syndrome.
Content of the invention
The present invention provides a kind of Chinese medicine composition treating infertility, and it is by the raw material of Chinese medicine medicine preparation of following weight proportion
Form：
Piece of antler 0.8-1.2g, Placenta Hominiss 2.8-3.2g, Stigma Croci 0.8-1.2g, Fructus Corni 8-12g, Semen Cuscutae 23-
27g, Cortex Eucommiae 14-16g, Radix Morindae Officinaliss 14-16g, Fructus Psoraleae 14-16g, Herba Epimedii 14-16g, Fructus Ligustri Lucidi 14-16g, Herba Ecliptae 14-
16g, Herba Taxilli 18-22g, Radix Angelicae Sinensis 14-16g, Radix Paeoniae Alba (parched) 14-16g, Radix Rehmanniae Preparata 14-16g, Fructus Rubi 14-16g.
Preferably, the Chinese medicine composition of the present invention, it is prepared from by the raw material of Chinese medicine medicine of following weight proportion：
Piece of antler 1g, Placenta Hominiss 3g, Stigma Croci 1g, Fructus Corni 10g, Semen Cuscutae 25g, Cortex Eucommiae 15g, Radix Morindae Officinaliss 15g, Psoralen
Fat 15g, Herba Epimedii 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Herba Taxilli 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba (parched) 15g, Radix Rehmanniae Preparata 15g, cover
Basin 15g.
In composition described above, the weight of each taste medicine is to be calculated with crude drug, can increase according to corresponding proportion when producing or subtract
Few, such as large-scale production can by kilogram in units of, or in units of ton, small-scale production can also with gram or milligram as list
Position, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, and fat
Or the patient of slight of stature, can accordingly adjust the proportioning of the amount of composition, increase or decrease less than 100%, drug effect is constant.
The Chinese medicine composition of the present invention, is through extraction or its other party by the raw material of Chinese medicine medical material forming above-mentioned formula
Formula is processed, and makes pharmaceutically active substance, subsequently, with this material as raw material, adds pharmaceutically acceptable carrier, according to medicine when needing
The routine techniquess of thing galenic pharmacy are made.Described active substance can be obtained it is also possible to pass through by extracting raw material of Chinese medicine respectively
The common raw material of Chinese medicine medical material that extracts obtains it is also possible to obtain by other means, such as：By pulverizing, squeezing, grind, sieve, ooze
Filter, extract, water extraction, alcohol extraction, ester carry, chromatograph etc. method obtain, these active substances can be extractum form material, Ke Yishi
Dry extract can also be fluid extract, and different according to preparation need to determine to make different concentration.
The pharmaceutical dosage forms of the Chinese medicine composition of the present invention, preferably unit dose, can when making pharmaceutical preparation
To make any pharmaceutically useful dosage form, these dosage forms are selected from：Tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule
Agent, hard capsule, soft capsule, oral liquid, mouth containing agent, granule, pill, powder, unguentum, sublimed preparation, suspensoid, solution,
Injection, suppository, ointment, plaster, cream, spray, patch.Preferably oral dosage form, most preferably ball
Agent.
The Chinese medicine composition of the present invention, can add some pharmaceutically acceptable carriers as needed, can adopt preparation
Learn routine techniquess and prepare this pharmaceutical preparation, such as pharmaceutically active substance is mixed with pharmaceutically acceptable carrier.Described medicine can connect
Be subject to carrier be selected from：Mannitol, Sorbitol, sorbic acid or potassium salt, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, salt
Sour cysteine, TGA, Methionine, vitamin A, vitamin C, Vitamin E, vitamin D, azone, EDETATE SODIUM, EDTA
Calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, chlorine
Change sodium, potassium chloride, sodium lactate, xylitol, maltose, glucose, Fructose, dextran, glycine, starch, sucrose, Lactose,
Mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, Polyvinylpyrrolidone, glycerol, propylene glycol, second
Alcohol, soil temperature 60-80, span-80, Cera Flava, lanoline, liquid paraffin, hexadecanol, gallate ester, agar, triethanolamine,
Basic amino acid, carbamide, allantoin, Calcium Carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-,
Phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc..
The Chinese medicine composition of the present invention determines usage and dosage when using according to the situation of patient.
The Chinese medicine composition of the present invention, when making medicament, the medicament of unit dose can the pharmaceutically active containing the present invention
Material 0.1-1000mg, remaining is pharmaceutically acceptable carrier.Pharmaceutically acceptable carrier can be preparation by weight
The 0.1-99.9% of gross weight.
The Chinese medicine composition of the present invention, its pharmaceutically active substance is to be obtained through extracting processing, such as following processing method：
1) take Chinese crude drug, plus the decocting of 3-8 times of weight boils 1-3 time, each 1-3 hour, obtain extracting solution, filtration, concentrate
To appropriate, it is prepared into extractum, with this extractum as active component, add pharmaceutically acceptable carrier when needing, according to pharmaceutical preparation
The routine techniquess learned make pharmaceutical preparation.
Or
2) take Chinese crude drug, plus the decocting of 3-8 times of weight boils 1-3 time, each 1-3 hour, obtain extracting solution, filtration, concentrate
To appropriate, adds ethanol to make to reach 70% concentration of alcohol, filter after standing, solution distills out ethanol, is condensed into extractum, with this
Extractum is active component, adds pharmaceutically acceptable carrier, the routine techniquess according to pharmaceutics make medicine system when needing
Agent.
Or
3) take Chinese crude drug, plus the alcohol reflux of the 90-95% (v/v) of 3-8 times of weight 1-3 time, each 1-3 hour,
Divide and take extracting solution, filtration, solution distills out ethanol, is condensed into extractum, and with this extractum as active component, when needing, addition medicine can
The carrier accepting, the routine techniquess according to pharmaceutics make pharmaceutical preparation.
The Chinese medicine composition of the present invention, side in Cornu Cervi Pantotrichum, Placenta Hominiss compatibility Semen Cuscutae etc. can the kidney warming replenishing essence, warm palace gravidity assisting；Bar
Halberd sky have functions that reinforcing the kidney and supporting YANG, wind-dispelling remove, strengthening the tendons and bones, impotence and seminal emission, uterus cold infertile, menoxenia, few abdomen can be treated cold
Bitterly, the card such as rheumatic arthralgia, muscles and bones impotence.Fructus Psoraleae has kidney invigorating and YANG supporting, astringent sperm contracting urine, the effect such as warming spleen and stopping diarrha, with Herba Epimedii
Compatibility, strengthens the effect of Kidney-invigorating and tendon-reinforcing bone, Radix Morindae Officinaliss, Semen Cuscutae, Fructus Psoraleae compatibility can play the work of YIN nourishing Yiyang, regulating menstruation and assisting pregnancy
With.Fructus Ligustri Lucidi has nourishing kidney tonifying liver, clearind deficient heat, and improving eyesight black hair etc. acts on, Herba Ecliptae enriching yin and nourishing kidney, cooling blood for hemostasis, two medicine compatibilities,
The moon power of nourishing the liver and kidney strengthens, and controls the card of the hepatic and renal YIN deficiency more.It is monarch drug altogether；Fructus Rubi the kidney warming replenishing essence, joins in nourishing kidney yin medicine
With yang-tonifying drug it is intended to treating YIN within YANG, make " YIN matched with sufficient YANG making living things fully vivid "；Radix Angelicae Sinensis, Radix Paeoniae Alba nourishing blood for regulating menstruation, tonifying Chong and Ren channels, with temperature
Kidney Yang-strengthening drug is ministerial drug altogether；Slightly help Radix Rehmanniae Preparata, Herba Taxilli, the Cortex Eucommiae, Stigma Croci vital energy regualting and blood circulation-promoting, traffic negative and positive again.All medicines share, grows
Invigorating the liver and kidney, replenishing essence blood-nourishing, tonifying Chong and Ren channels, negative and positive in balance kidney, adjust " kidney menses one rushes arbitrary born of the same parents official " Reproductive Axis, finally reach
It is in harmonious proportion to " through water ", hemapodium essence is prosperous, punching times purpose smoothly, embody the traditional Chinese medical science " kidney governing reproduction ", " Tai Yunzhi road ", be really achieved
Sun liter blood is long, the effect of regulating menstruation and assisting pregnancy.
Further illustrate beneficial effects of the present invention below by way of experimental data：
Case 1
【Physical data】Wang's sex：Female's age：28 the beginning of the year examined：On January 3rd, 2015
【Medical history】Main suit：Marriage unpregnancy 3 years companions menstrual period entanglement more than 2 years, excessive menstruation.7-9 after menstruation all mistakes every time
My god, amount is special many, and color purple is black little clot, abdominal pain with tenesmus, dizziness, is in a cold sweat.Last menstrual period 2014.12.8
【Have a medical check-up】, arteries and veins two chi string disease greatly, pass chi all sinks weak；Yellowish fur.Doctor trained in Western medicine auxiliary examination：Gonadal hormone six carries
Show：LH, P are substantially low；E2, T are substantially higher；B ultrasonic is pointed out：Uterus adnexa shows no obvious abnormalities, and Endometrium is thin, in conjunction with clinic.
【Diagnosis】, tcm diagnosis：Menoxenia, infertile, Western medicine diagnose：Abnormal uterine bleeding
【Method for the treatment of】, warming YANG and invigorating QI, regulating menstruation and assisting pregnancy
Prescription：
Piece of antler 1g, Placenta Hominiss 3g, Stigma Croci 1g, Fructus Corni 10g, Semen Cuscutae 25g, Cortex Eucommiae 15g, Radix Morindae Officinaliss 15g, Psoralen
Fat 15g, Herba Epimedii 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Herba Taxilli 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba (parched) 15g, Radix Rehmanniae Preparata 15g, cover
Basin 15g.
Two examine on January 10th, 2015：After medication, menstrual blood volume reduces earlier above, and color is red, and not bitterly, arteries and veins cun chi is all heavy for abdominal part, right
Close heavy late, left close heavy string.
Continuously take after two months, menstruation i.e. net, normochromic on the 5th, not bitterly, headache is inconspicuous, in menstrual period the 3rd for abdomen
Its six prompting " LH is slightly biased low, and remaining hormone at different levels has all recovered normal " of check gonadal hormone, top plus-minus is continuous to be treated three months, in
In October, 2015 incoming all announcement is pregnant.
Case 2
Zhai, female, 34 years old.The first visit date：On August 24th, 2014.Main suit：Menstruation is delayed more than 12 years, infertile
History of present illness：The long-term menoxenia of patient, amount less, darkish complexion, have block, doctor trained in Western medicine once gave the treatment such as Progesterone and did not imitated, front
Doctor was once neither imitated with the treatment such as warming the meridian and activating blood circulation, tonifying kidney and nourishing liver nourshing blood and promoting blood circulation, and 2002 because of ectopic pregnancy excision one oviductus lateraliss.
Patient existing symptoms include：The menstruation amount of delaying is few, darkish complexion, fixture block, dim complexion, and fatigue is weak, fine inquiry patient's irascible temperament on ordinary days
Irritability, susceptible to sorrow and being about to weep, hypochondriac pain, sighing frequently, dry mouth with bitter taste, receive food still, eating is cold and cool, lower abdomen pain fear of cold, two flanks
Butt crack tenderness weakly positive, rebound tenderness is positive, soreness of waist pain, profuse leukorrhea, stool first being dry and then watery, day row 1 time, it is poor to sleep.Purplish tongue
Side cusp thorn, in tongue, root thickness is greasy, deep and hesitant pulse.Estrogen level measures and reaches normal value.Because feelings will is unsuccessful before interrogating further 3 months
Menstruation is caused not rise so far again again, existing waist and knee is cold, lack when the cold pain of abdomen, nocturia frequency, hyposexuality or the enuresis.Have a strong impact on trouble
Person's Working Life,
Western medicine diagnose：Menoxenia, tcm diagnosis：Delayed menstrual cycle, Chinese medical discrimination：Depression of liver-QI kidney yang declines tired, the rule for the treatment of：Dredge
Liver resolving depression, liver and kidney tonifying
Prescription：
Piece of antler 1g, Placenta Hominiss 3g, Stigma Croci 1g, Fructus Corni 10g, Semen Cuscutae 25g, Cortex Eucommiae 15g, Radix Morindae Officinaliss 15g, Psoralen
Fat 15g, Herba Epimedii 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Herba Taxilli 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba (parched) 15g, Radix Rehmanniae Preparata 15g, cover
Basin 15g.
7 pairs, it is decocted in water for oral dose, day is one, sooner or later point Winton clothes.
Two examine：The readme 7 pairs of personality that take traditional Chinese medicine are clearly better, and hypochondriac pain bitter taste cold and pain in the lower abdomen soreness of waist alleviation of pain is light, and the enuresis takes a turn for the better, band
Lower amount reduces, and purplish tongue side cusp pierces, and in tongue, root thickness is greasy, deep and hesitant pulse.
Three examine：Modern patient is joyful and arrive, readme take traditional Chinese medicine the 15th secondary when menstrual onset, polychrome is dark red accompanies a large amount of blood for amount
Block, rises the 3rd day and turns red through color, and patient feels refreshed, and hypochondriac pain bitter taste cold and pain in the lower abdomen soreness of waist pain is relieved, and the enuresis disappears
Move back, dimly red tongue, tongue is slightly greasy in vain, deep-thready pulse.Take traditional Chinese medicine altogether 3 months with disease plus-minus afterwards, menstruation monthly comes twice again, spirit is refreshing
Hurry up, Working Life recovers normal, and follow-up menstruation in 10 months connects and normally comes at the appointed time.
Case 3
Huang, female, 34 years old.Dalian government functionary.
【History of present illness】Married 7 years unpregnancies, physiology is normal on inspection for men and women.Winter in 2013, feel dizzy, weary
Power, morning face swells, afternoon swelling of the feet, menses is uncomfortable.Spring in 2015, PD is serious.July 20 the same year to examine.Amenorrhea half a year,
Leucorrhea is many.Soreness of the waist and knees, fear of cold, dreaminess, poor appetite, dysuria, stool is half congealed after first tying.Body of the tongue is light red, while there being indentation, tongue is white
Sliding, deep-thready pulse.
【Through pregnant history】Nearly 3 years of menoxenia, on July 3 2015 last menstrual period time, does not give birth to.
【Diagnosis】Tcm diagnosis：Infertility, Western medicine diagnose：Infertility
【Method for the treatment of】Tonify Qi of the kidney, warming YANG gravidity assisting
【Prescription】
Piece of antler 1g, Placenta Hominiss 3g, Stigma Croci 1g, Fructus Corni 10g, Semen Cuscutae 25g, Cortex Eucommiae 15g, Radix Morindae Officinaliss 15g, Psoralen
Fat 15g, Herba Epimedii 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Herba Taxilli 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba (parched) 15g, Radix Rehmanniae Preparata 15g, cover
Basin 15g.
7 pairs, it is decocted in water for oral dose, day is one, sooner or later point Winton clothes.
【Two examine】Above clothes, anasarca significantly disappears, and appetite increases.Former side takes 15 days again.
【Three examine】Though the card such as Mental fatigue, aversion to cold take a favorable turn, passes through, taking every menstrual phase 28 days, the 10th day menstrual period after two months
Detection follicle：18*19*18mm and inner membrance 9 all reach
Case 4
【Physical data】Lee, female, 27 years old, married 3 years unpregnancies.On March 10th, 2015 examines.
【Main suit】Married 3 years unpregnancies
【History of present illness】3 years unpregnancies after marriage, nearly half a year menstruation is gradually delayed, smooth less and not than before through row amount, and color is purple dark, has
Clot pass through every time first 2 days first sense waist aching and tired, few abdomen tenesmus, few abdomen pain occurs immediately, the pain increased within second day through row, no
Can stand, cool with extremity, it is in a cold sweat, nausea and vomiting, pale complexion, 5 days about through to the greatest extent, leucorrhea color measures many, lower abdomen in vain at ordinary times
Both sides dull pain.Look into lower abdomen tenderness, on the left of lower abdomen, have streak lump.Pale tongue is dark, white and thin fur, stringy and hesitant pulse.
【Diagnosis】Tcm diagnosis：Infertility, Western medicine diagnose：Infertility
【Method for the treatment of】Blood circulation promoting and blood stasis dispelling, Chong and Ren Meridians regulating
Piece of antler 1g, Placenta Hominiss 3g, Stigma Croci 1g, Fructus Corni 10g, Semen Cuscutae 25g, Cortex Eucommiae 15g, Radix Morindae Officinaliss 15g, Psoralen
Fat 15g, Herba Epimedii 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Herba Taxilli 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba (parched) 15g, Radix Rehmanniae Preparata 15g, cover
Basin 15g continuously takes two months and becomes pregnant.
The present invention compares with medicine of the prior art, and advantage is as follows：
The advantage one regulating menstruation cycle
Advantage two patient thin to follicular development and endometrium has improvement
Advantage three improves Uterine Artery Blood Flow
Specific embodiment
Further illustrate the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Piece of antler 1g, Placenta Hominiss 3g, Stigma Croci 1g, Fructus Corni 10g, Semen Cuscutae 25g, Cortex Eucommiae 15g, Radix Morindae Officinaliss 15g, Psoralen
Fat 15g, Herba Epimedii 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Herba Taxilli 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba (parched) 15g, Radix Rehmanniae Preparata 15g, cover
Basin 15g.
Take Chinese crude drug, plus the decocting of 5 times of weight boils 3 times, 2 hours every time, obtains extracting solution, filtration, it is concentrated into appropriate, system
Standby one-tenth extractum, with this extractum as active component, adds pharmaceutically acceptable carrier, according to the conventional skill of pharmaceutics when needing
Art makes pill.
Embodiment 2
Piece of antler 0.8g, Placenta Hominiss 2.8g, Stigma Croci 0.8g, Fructus Corni 8g, Semen Cuscutae 23g, Cortex Eucommiae 14g, Radix Morindae Officinaliss
14g, Fructus Psoraleae 14g, Herba Epimedii 14g, Fructus Ligustri Lucidi 14g, Herba Ecliptae 14g, Herba Taxilli 18g, Radix Angelicae Sinensis 14g, Radix Paeoniae Alba (parched) 14g, Radix Rehmanniae Preparata
Yellow 14g, Fructus Rubi 14g.Take Chinese crude drug, plus the decocting of 5 times of weight boils 2 times, 2 hours every time, obtains extracting solution, filtration, concentrate
To appropriate, adds ethanol to make to reach 70% concentration of alcohol, filter after standing, solution distills out ethanol, is condensed into extractum, with this
Extractum is active component, adds pharmaceutically acceptable carrier, the routine techniquess according to pharmaceutics make tablet when needing.
Or
Embodiment 3
Piece of antler 1.2g, Placenta Hominiss 3.2g, Stigma Croci 1.2g, Fructus Corni 12g, Semen Cuscutae 27g, Cortex Eucommiae 16g, Radix Morindae Officinaliss
16g, Fructus Psoraleae 16g, Herba Epimedii 16g, Fructus Ligustri Lucidi 16g, Herba Ecliptae 16g, Herba Taxilli 122g, Radix Angelicae Sinensis 16g, Radix Paeoniae Alba (parched) 16g, Radix Rehmanniae Preparata
Yellow 16g, Fructus Rubi 16g.
Take Chinese crude drug, plus the alcohol reflux of 95% (v/v) of 5 times of weight 2 times, 2 hours every time, point take extracting solution,
Filtration, solution distills out ethanol, is condensed into extractum, with this extractum as active component, adds pharmaceutically acceptable carrier when needing,
Routine techniquess according to pharmaceutics make capsule.
Claims (8)
1. a kind of Chinese medicine composition treating infertility, it is prepared from by the raw material of Chinese medicine medicine of following weight proportion：
Piece of antler 0.8-1.2g, Placenta Hominiss 2.8-3.2g, Stigma Croci 0.8-1.2g, Fructus Corni 8-12g, Semen Cuscutae 23-27g, Du
Secondary 14-16g, Radix Morindae Officinaliss 14-16g, Fructus Psoraleae 14-16g, Herba Epimedii 14-16g, Fructus Ligustri Lucidi 14-16g, Herba Ecliptae 14-16g, Mulberry
Parasitic 18-22g, Radix Angelicae Sinensis 14-16g, Radix Paeoniae Alba (parched) 14-16g, Radix Rehmanniae Preparata 14-16g, Fructus Rubi 14-16g.
2. Chinese medicine composition according to claim 1, it is prepared from by the raw material of Chinese medicine medicine of following weight proportion：
Piece of antler 1g, Placenta Hominiss 3g, Stigma Croci 1g, Fructus Corni 10g, Semen Cuscutae 25g, Cortex Eucommiae 15g, Radix Morindae Officinaliss 15g, Fructus Psoraleae
15g, Herba Epimedii 15g, Fructus Ligustri Lucidi 15g, Herba Ecliptae 15g, Herba Taxilli 20g, Radix Angelicae Sinensis 15g, Radix Paeoniae Alba (parched) 15g, Radix Rehmanniae Preparata 15g, cover basin
Sub- 15g.
3. Chinese medicine composition according to claim 1, is through carrying by the raw material of Chinese medicine medical material forming above-mentioned formula
Take or other modes processing, make pharmaceutically active substance, subsequently, with this material as raw material, add pharmaceutically acceptable when needing
Carrier, the routine techniquess according to pharmaceutics are made.
4. Chinese medicine composition according to claim 1, can make any pharmaceutically useful dosage form when making pharmaceutical preparation.
5. Chinese medicine composition according to claim 1, described dosage form is selected from：Tablet, capsule, oral liquid, mouth containing agent,
Granule, pill, powder, unguentum, sublimed preparation, suspensoid, injection, suppository, ointment, plaster, cream, spray, patch,
Drop pill.
6. the preparation method of the Chinese medicine composition described in claim 1, step is as follows：
1) take Chinese crude drug, plus the decocting of 3-8 times of weight boils 1-3 time, each 1-3 hour, obtain extracting solution, filtration, it is concentrated into suitable
Amount, is prepared into extractum, with this extractum as active component, adds pharmaceutically acceptable carrier, according to pharmaceutics when needing
Routine techniquess make pharmaceutical preparation.
7. the preparation method of the Chinese medicine composition described in claim 1, step is as follows：
2) take Chinese crude drug, plus the decocting of 3-8 times of weight boils 1-3 time, each 1-3 hour, obtain extracting solution, filtration, it is concentrated into suitable
Amount, adds ethanol to make to reach 70% concentration of alcohol, filters, solution distills out ethanol, is condensed into extractum, with this extractum after standing
For active component, when needing, add pharmaceutically acceptable carrier, the routine techniquess according to pharmaceutics make pharmaceutical preparation.
8. the preparation method of the Chinese medicine composition described in claim 1, step is as follows：
3) take Chinese crude drug, plus the alcohol reflux of the 90-95% (v/v) of 3-8 times of weight 1-3 time, each 1-3 hour, point take
Extracting solution, filtration, solution distills out ethanol, is condensed into extractum, with this extractum as active component, adds medicine to be subjected to when needing
Carrier, the routine techniquess according to pharmaceutics make pharmaceutical preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611024078.2A CN106421200B (en) | 2016-11-18 | 2016-11-18 | A kind of Chinese medicine composition for treating infertility |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611024078.2A CN106421200B (en) | 2016-11-18 | 2016-11-18 | A kind of Chinese medicine composition for treating infertility |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106421200A true CN106421200A (en) | 2017-02-22 |
| CN106421200B CN106421200B (en) | 2019-08-09 |
Family
ID=58220640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611024078.2A Active CN106421200B (en) | 2016-11-18 | 2016-11-18 | A kind of Chinese medicine composition for treating infertility |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106421200B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116135221A (en) * | 2023-04-19 | 2023-05-19 | 云南琼月企业管理有限公司 | Wuzi Yichong prescription and preparation and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049372A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese medicament for treating barrenness caused by obstruction of ovulation |
-
2016
- 2016-11-18 CN CN201611024078.2A patent/CN106421200B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049372A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Preparation of Chinese medicament for treating barrenness caused by obstruction of ovulation |
Non-Patent Citations (5)
| Title |
|---|
| 刘海燕等: "内外合治子宫内膜异位症继发不孕120例", 《新中医》 * |
| 夏丽颖等: "曲秀芬教授治疗免疫性不孕经验", 《河北中医》 * |
| 夏丽颖等: "补肾消抗汤治疗免疫性不孕的临床疗效分析", 《中医药信息》 * |
| 张风华等: "补肾助孕汤治疗肾虚型不孕症的相关研究", 《中国社区医师》 * |
| 高学敏等主编: "《临床中药学》", 31 January 2006, 河北科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116135221A (en) * | 2023-04-19 | 2023-05-19 | 云南琼月企业管理有限公司 | Wuzi Yichong prescription and preparation and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106421200B (en) | 2019-08-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103007234B (en) | Traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis and preparation method of preparation | |
| CN103169881B (en) | Chinese medicament health product for supplementing female hormone for women during menopause and preparation method thereof | |
| CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
| CN102416079A (en) | Chinese patent medicine for treating leucoderma | |
| CN102058715B (en) | Chinese medicine preparation for treating chronic prostatitis and preparation method thereof | |
| CN104958607A (en) | Traditional Chinese medicine composition for treating burning mouth syndromes of climacteric women and preparation method thereof | |
| CN101632750A (en) | Chinese medicinal composition for replenishing essence, filling marrow, boosting kidney and strengthening yang and preparation method thereof | |
| CN104474500A (en) | Traditional Chinese medicine health product capable of enriching blood and regulating menstruation and preparation method of traditional Chinese medicine health product | |
| CN104225215A (en) | Traditional Chinese medicine for treating insomnia | |
| CN102688361B (en) | A kind of Chinese medicine composition treating dysmenorrhea and preparation thereof | |
| CN104435519A (en) | Pharmaceutical composition for treating primary dysmenorrhea | |
| CN103990058A (en) | Menstruation promoting and vigor keeping paste | |
| CN106421200B (en) | A kind of Chinese medicine composition for treating infertility | |
| CN102293923B (en) | Application of Tibetan medicinal composition to preparation of medicament for preventing and treating osteoporosis | |
| CN104784538A (en) | Chinese medicinal preparation for treating diabetes and preparation method | |
| CN103550604A (en) | Traditional Chinese medicine for treating neurodermatitis | |
| CN106177636A (en) | Replenishing QI to invigorate the spleen qi-restoratives soup | |
| CN105233078A (en) | Traditional Chinese medicine composition for treating viral hepatitis | |
| CN100358566C (en) | Traditional Chinese medicine preparation for treating internal weakness | |
| CN104771695A (en) | Ovulation promoting traditional Chinese medicine for treating female infertility | |
| CN103041017B (en) | Traditional Chinese medicine preparation for treating functional uterine bleeding and preparation method thereof | |
| CN106266994A (en) | A kind of for Chinese medicine composition treating depression and preparation method thereof | |
| CN105726868A (en) | Pharmaceutical preparation for treating first-trimester threatened abortion with anticardiolipin antibody positive | |
| CN105616837A (en) | Traditional Chinese medicine for treating acne and preparation method thereof | |
| CN109806376A (en) | A kind of preparation and preparation method thereof for treating primary stubbornness dysmenorrhea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |