CN101632750A - Chinese medicinal composition for replenishing essence, filling marrow, boosting kidney and strengthening yang and preparation method thereof - Google Patents
Chinese medicinal composition for replenishing essence, filling marrow, boosting kidney and strengthening yang and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicinal composition for replenishing essence, filling marrow, boosting kidney and strengthening yang and a preparation method thereof. The Chinese medicinal composition is prepared from barbary wolfberry fruit, south dodder seed, raspberry, plantain seed and Chinese magnoliavine fruit. Pharmacodynamic experiments show that the Chinese medicinal composition has the effects of replenishing essence, filling marrow, boosting kidney and strengthening yang. The Chinese medicinal composition can be used for treating diseases such as weak health, kidney depletion and impotence, spermatorrhea, turbid urine and the like.
Description
Technical field
The present invention relates to field of medicaments, particularly relate to Chinese medicine composition of a kind of benefiting essence and marrow, boosting kidney and strengthening yang and preparation method thereof.
Background technology
The traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, main store essential substances, and main water improving inspiration by invigorating kidney-QI, main bone, living marrow are had one's ideas straightened out in ear and two the moon, its Hua Zaifa.The vital organs of the human body all need the nourishing of kidney essense, and it is the power of human-body biological action, is the root of human body reproductive development, the motive power of internal organs function action.The vital essence of kidney can be divided into kidney yin, kidney yang two aspects from effect, kidney yin and kidney yang mutual dependence for existence, mutual restriction are kept the dynamic equilibrium of human body.Support if the congenital weakness of human body, the day after tomorrow are lost, work hard for a good while, survive converge, chamber overdoes, or the functional disorder that prolonged illness is impairment of the kidney, cause such as worn with age all can cause kidney finally causes a series of symptoms of suffering from a deficiency of the kidney.Mainly show as soreness of the waist and knees, five worried heat, dizziness and tinnitus, insomnia forgetfulness, night sweat; The man shows as symptoms such as impotence and premature ejaculation, seminal emission; The woman shows as performances such as infrequent menstruation amenorrhea, constipation, the few tongue thready pulse of red tongue.Kidney yang declines partially then and to be insufficiency of kidney-YANG, show as pale complexion or pitch-dark, the acid of waist knee joint is cold, soul is depressed, the impotence in male premature ejaculation, is had loose bowels etc. just before dawn at woman's infertility, enuresis edema.Therefore, suffering from a deficiency of the kidney not only only shows as the with countless changes of sexual function aspect, also covers a series of pathological changes of whole body.In western medicine, kidney is the heavy organ in the urinary system.And the renal function of theory of Chinese medical science has substantially exceeded the scope of urinary system, and growth, aging, intelligence, the fertility of it and human body all has compact relation.
Symptoms such as the lumbago that Chinese traditional treatment causes because of suffering from a deficiency of the kidney, seminal emission, sexual impotence should be distinguished deficiency of the kidney yin or insufficiency of kidney-YANG earlier.The most flush crimsons of deficiency of YIN person, dysphoria with feverish sensation in the chest palms and soles; Yang deficiency person then is afraid of cold, coolness of extremities, complexion dimness, diseases such as clear urine in large amounts and hypofunction.Mostly yang-tonifying drug is hot medicine, as Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Cornu Cervi Pantotrichum, Herba Epimedii, Herba Cistanches, Radix Morindae Officinalis etc.; Mostly YIN-tonifying drug is sweet cold medicine, as Herba Dendrobii, Rhizoma Polygonati Odorati, Fructus Corni, Fructus Lycii, Fructus Ligustri Lucidi, Herba Taxilli, Radix Panacis Quinquefolii etc.The representative of nourishing YIN Chinese patent medicine commonly used is a LIUWEI DIHUANG WAN clinically at present, and the representative of YANG invigorating Chinese patent medicine is a JINGUI SHENQI WAN.The dissimilar patients' that suffers from a deficiency of the kidney Therapeutic Method is distinct, and some medicines at the insufficiency of kidney-YANG patient can not be used for the deficiency of the kidney yin patient; The medicine of equally specially controlling the deficiency of the kidney yin patient also must not be used for the insufficiency of kidney-YANG patient.Specially the medicine of tonifying kidney-yin is inoperative to kidney yang, if after the patient of insufficiency of kidney-YANG has obeyed, tends to make the symptom of suffering from a deficiency of the kidney further to increase the weight of.If the deficiency of the kidney yin patient takes this drug overdose for a long time, will cause excess of YIN to decrease sun, the patient is faced with the danger of insufficiency of kidney-YANG equally.In addition because the patient that suffers from a deficiency of the kidney often can not judge accurately that own symptom belongs to deficiency of the kidney yin or insufficiency of kidney-YANG, so the patient is difficult to select suitable drug to be used for the treatment of.Therefore select the Drug therapy of the equilibrium between yin and yang of tonifying both YIN and YANG and then recovery kidney to suffer from a deficiency of the kidney very crucial.
Summary of the invention
The Chinese medicine composition that the purpose of this invention is to provide a kind of benefiting essence and marrow, boosting kidney and strengthening yang.
Another object of the present invention provides the preparation method of the Chinese medicine composition of benefiting essence and marrow, boosting kidney and strengthening yang.
Chinese medicine composition of the present invention is to be made by following weight proportion crude drug: Fructus Lycii 35.0%～43.5%; Semen Cuscutae 25.1%～34.5%; Fructus Rubi 17.5%～25.3%; Semen Plantaginis 0.1%～8.5%; Fructus Schisandrae Chinensis 0.1%～4.2%.
The preferred Chinese medicine composition of the present invention is to be made by following weight proportion crude drug: Fructus Lycii 35.5%～42.5%; Semen Cuscutae 25.5%～33.5%; Fructus Rubi 18.5%～24.5%; Semen Plantaginis 5.0%～8.5%; Fructus Schisandrae Chinensis 0.5%～4.2%
The preferred Chinese medicine composition of the present invention is to be made by following weight proportion crude drug: Fructus Lycii 35.9%～40.5%; Semen Cuscutae 27.2%～32.4%; Fructus Rubi 18.8%～22.3%; Semen Plantaginis 7.9%～8.5%; Fructus Schisandrae Chinensis 2%～4.2%.
The preferred Chinese medicine composition of the present invention is to be made by following weight proportion crude drug: Fructus Lycii 37.5%; Semen Cuscutae 29.2%; Fructus Rubi 20.8%; Semen Plantaginis 8.3%; Fructus Schisandrae Chinensis 4.2%.
The preferred Chinese medicine composition of the present invention is to be made by following weight proportion crude drug: Fructus Lycii 36.7%, Semen Cuscutae 28.1%, Fructus Rubi 22.9%, Semen Plantaginis 8.3%, Fructus Schisandrae Chinensis 4.0%.
The preferred Chinese medicine composition of the present invention is to be made by following weight proportion crude drug: Fructus Lycii 43.5%, Semen Cuscutae 28.2%, Fructus Rubi 17.5%, Semen Plantaginis 7.7%, Fructus Schisandrae Chinensis 3.1%.
The preferred Chinese medicine composition of the present invention is to be made by following weight proportion crude drug: Fructus Lycii 40.4%, Semen Cuscutae 30.3%, Fructus Rubi 20.3%, Semen Plantaginis 8.5%, Fructus Schisandrae Chinensis 0.5%.
In the Chinese medicine composition of the present invention, Fructus Lycii, Semen Cuscutae, Fructus Rubi benefiting kidney-essence, with realize that smart sufficient marrow fills, kidney qi is from solid effect.Assistant is with Fructus Schisandrae Chinensis, Semen Plantaginis supplementing the kidney to control the nocturnal, to strengthen the curative effect of medicine.Sun is asked in yin nourishing in the side, mend and not dry, thus sterile etc. all effective in cure to the soreness of waist and knee joint, impotence and premature ejaculation, emission and the oligospermia that cause by suffering from a deficiency of the kidney, and the property of medicine is gentle, and the anxiety of the big heat of no Da Xin is so the patient all has no adverse reaction.
The active component of Chinese medicine composition of the present invention and the preparation of preparation can be adopted following method: to raw material simply pulverize, one or several use in conjunction preparations in the extraction, water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method, make preparation then.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, but this can not limit protection scope of the present invention.
In the Chinese medicine composition of the present invention, for the preparation method of the Chinese medicine composition of the benefiting essence and marrow of the present invention of adopting five tastes medicament composing prescription, boosting kidney and strengthening yang, method is as follows:
A. Fructus Lycii, Semen Cuscutae, Fructus Rubi, Semen Plantaginis, the Fructus Schisandrae Chinensis of getting prescription proportioning weight are standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 5～10 times of water gagings for the first time, extracted 1～5 hour, and added 5～10 times of water gagings for the second time, extracted 1～5 hour, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing is placed, and filters, and adds simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
The preparation method of the Chinese medicine composition of the preferred benefiting essence and marrow of the present invention, boosting kidney and strengthening yang, among the step b, among the step b, sealing is placed more than 1 day; Concentrated solution is in the time of 40～80 ℃, and being concentrated into proportion is 1.00～1.30.
The preparation method of the Chinese medicine composition of the preferred benefiting essence and marrow of the present invention, boosting kidney and strengthening yang, among the step b, among the step b, sealing was placed 1～7 day; Concentrated solution is in the time of 50～70 ℃, and being concentrated into proportion is 1.05～1.25.
In Chinese medicine composition of the present invention and preparation method thereof, described Semen Plantaginis is the processed with salt Semen Plantaginis; Fructus Schisandrae Chinensis is the processed with wine Fructus Schisandrae Chinensis.
Chinese medicine composition of the present invention can add various conventional adjuvant required when preparing different dosage form, makes any preparation on the pharmaceutics; As add adjuvants such as disintegrating agent, lubricant, binding agent and be prepared into any common formulations with the method for Chinese medicinal of routine, as tablet, sugar coated tablet, film coated tablet, enteric coated tablet, powder, capsule, soft capsule, electuary, oral liquid, granule, drop pill, micropill, intramuscular injection agent, instillation, unguentum, ointment, plaster etc.; The best is made tablet, drop pill, oral liquid, granule, capsule.
Chinese medicine composition of the present invention has the effect of benefiting essence and marrow, boosting kidney and strengthening yang.
The application of Chinese medicine composition of the present invention in preparation treatment lumbago, seminal emission, sexual impotence medicine.
The application of Chinese medicine composition of the present invention in medicine is suffered from a deficiency of the kidney in the preparation treatment.
The indication of Chinese medicine composition of the present invention is a physical weakness, deficiency of the kidney sexual impotence, emission, urine muddiness.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
In order to understand the present invention better, logical below clinical pharmacodynamic observation is further set forth the Chinese medicine composition of the present invention beneficial effect of (being called for short kidney tonifying liquid).Below used kidney tonifying liquid prepares according to embodiment 26 in the test.
The one kidney tonifying liquid clinical research of test example
One. clinical data
1, ordinary circumstance: observe 50 routine patients and be the male, wherein 20 years old of the age minimum, maximum 58 years old.The shortest person of the course of disease 6 months, elder 3 years.
2, case is selected: meet health ministry " new Chinese medicine clinical research guideline " and determine the suffering from a deficiency of the kidney property diagnosis in the diagnostic criteria.
Lumbago: the waist one or both sides are aching and limp or continuously have a pain, happiness rub by, meet labor what for, for sleeping in then alleviation of pain, the light red tongue tongue is few, thready and weak pulse.
Seminal emission: the existing normality life of married man, but still have more seminal emission, or the bachelor passes out semen frequently (1～3 day 1 time), continue more than 1 month, and with soreness of the waist and knees, vertigo and tinnitus, coldness of the body with chills, impotence and premature ejaculation or little sleep disturbed by dreams, dream is then passed out semen, the cardiopalmus excessive thirst, light red tongue is tender, deep-thready pulse or count accurately.
Sexual impotence: during between twenty and fifty man's sexual intercourse because penis can not erect effectively, and the chance that has sexual intercourse can not carry out more than 75% and with penis cold, the acid of waist knee joint is cold, cold sperm premature ejaculation, white and thin fur, deep and weak pulse or dizzy forgetful, tinnitus and soreness of loins, dysphoria with feverish sensation in the chest palms and soles, the few tongue of red tongue, thready and rapid pulse.
Two. observational technique and result
1, observational technique: kidney tonifying liquid oral administration, obey each 30ml every day 2 times.One month is a course of treatment, the other drug of stopping using in the middle of this.
2, curative effect is judged: be divided into by the unified efficacy assessment standard in the health ministry " new Chinese medicine clinical guidance principle ":
(1) cure in the recent period:
Lumbago: lumbago and related symptoms thereof all disappear, and do not influence activity and work, follow up a case by regular visits in 3 months, and there is normality to give birth to the reviver and no longer passes out semen, no sexual life person, seminal emission in every month is less than transference cure 5 times.
Sexual impotence: treat in back 3 months erection＞90, the energy success more than 75% of sexual intercourse chance.
(2) produce effects
Lumbago: waist pain be close to disappear, and only mild pain is arranged when fatigue or Changes in weather, and perhaps the state of an illness is transferred to slightly by severe.
Seminal emission: the person that has the sexual life, seminal emission in every month still has 1～2 time, no sexual life person, the minimizing 1 time of passing out semen weekly, cardinal symptom alleviates.
Sexual impotence: the treatment back erects＞90, the energy success more than 50% of sexual intercourse chance.
(3) effective:
Lumbago: sings and symptoms has and alleviates and improve, but the state of an illness and unstable has recurrence after the drug withdrawal, and is influential to heavy physical labour.
Seminal emission: the person that has the sexual life, seminal emission in every month still has 2～3 times, no sexual life person, the minimizing 1 time of passing out semen weekly, cardinal symptom alleviates.
Sexual impotence: erect improvement arranged in the treatment back, the energy success more than 25% of sexual intercourse chance.
(4) invalid
More than before and after three kinds of disease medications various symptoms all do not have improvement.
3, the responding time of taking medicine: see Table 1.
Table 1 50 example clothes kidney tonifying liquid responding time statistical tables
Several 15 days 30 days 45 days 60 days 75 days natural law that on average take effect of project example
Lumbago 17 25631 41
Pass out semen 15 2652 37
Sexual impotence 18 12465 55
Medicine time, the shortest person can take effect in 15 days as can be seen by table 1.Be sexual impotence than the elder average medicine time.
4, therapeutic effect: see Table 2
Table 2 50 example clothes kidney tonifying liquid clinical efficacy statistical tables
Project example number is cured produce effects enabledisable effective percentage (%) in the recent period
Lumbago 17 10 520 100
Pass out semen 15 12 210 100
Sexual impotence 18 11 421 94
By table 2 as can be seen, oral kidney tonifying liquid has significant therapeutical effect to three kinds of diseases, and total effective rate reaches 98%.
The specific embodiment
Further set forth the preparation method of medicine of the present invention by the following examples.
Embodiment 1
A. get Fructus Lycii 80.8g, Semen Cuscutae 60.6g, Fructus Rubi 40.6g, processed with salt Semen Plantaginis 17g, 1g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 6 times of water gagings for the first time, extracted 1 hour, and added 5 times of water gagings for the second time, extracted 1 hour, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 2 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 2
A. get Fructus Lycii 73g, Semen Cuscutae 56g, Fructus Rubi 45g, processed with salt Semen Plantaginis 16.6g, 8g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 8 times of water gagings for the first time, extracted 3 hours, and added 8 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 1 day, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 3
A. get Fructus Lycii 72g; Semen Cuscutae 56g; Fructus Rubi 40g; Processed with salt Semen Plantaginis 16g; 8g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 6 times of water gagings for the first time, extracted 2 hours, and added 5 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 2 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 4
A. get Fructus Lycii 80g; Semen Cuscutae 60g; Fructus Rubi 40g; Processed with salt Semen Plantaginis 16g; 4g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 9 times of water gagings for the first time, extracted 4 hours, and added 8 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 1 day, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 5
A. get Fructus Lycii 82g, Semen Cuscutae 48g, Fructus Rubi 45g, processed with salt Semen Plantaginis 15g, 6g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 7 times of water gagings for the first time, extracted 4 hours, and added 5 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 1 day, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 6
A. get Fructus Lycii 73.6g; Semen Cuscutae 50.2g; Fructus Rubi 50.6g; Processed with salt Semen Plantaginis 17.2g; 8.4g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 10 times of water gagings for the first time, extracted 3 hours, and added 10 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 1 day, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 7
A. get Fructus Lycii 43.5g; Semen Cuscutae 28.6g; Fructus Rubi 17.5g; Semen Plantaginis 7.4g; Fructus Schisandrae Chinensis 3g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 6 times of water gagings for the first time, extracted 2 hours, and added 6 times of water gagings for the second time, extracted 1 hour, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 1 day, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 8
A. get Fructus Lycii 36g; Semen Cuscutae 32g; Fructus Rubi 22g; Processed with salt Semen Plantaginis 8g, 2g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 9 times of water gagings for the first time, extracted 4 hours, and added 6 times of water gagings for the second time, extracted 2.5 hours, the medicinal residues squeezing filters, and gets extracting solution, 45 ℃ the time, being concentrated into proportion is 1.10 with extracting solution, adds ethanol, stir, sealing was placed 2 days, filtered, add simple syrup in the filtrate, and be adjusted to 3000ml, promptly with distilled water.
Embodiment 9
A. get Fructus Lycii 69.8g; Semen Cuscutae 64.8g; Fructus Rubi 44.6g; Processed with salt Semen Plantaginis 16.4g; 4.4g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 7 times of water gagings for the first time, extracted 2 hours, and added 5 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, 65 ℃ the time, being concentrated into proportion is 1.20 with extracting solution, adds ethanol, stir, sealing was placed 2 days, filtered, add simple syrup in the filtrate, and be adjusted to 2500ml, promptly with distilled water.
Embodiment 10
A. get Fructus Lycii 40.5g; Semen Cuscutae 27.2g; Fructus Rubi 22.3g; Semen Plantaginis 8.5g; Fructus Schisandrae Chinensis 1.5g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 8 times of water gagings for the first time, extracted 3 hours, and added 5 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, 60 ℃ the time, being concentrated into proportion is 1.15 with extracting solution, adds ethanol, stir, sealing was placed more than 1 day, filtered, add simple syrup in the filtrate, and be adjusted to 1350ml, promptly with distilled water.
Embodiment 11
A. get Fructus Lycii 36g; Semen Cuscutae 32.5g; Fructus Rubi 20g; Semen Plantaginis 8g; Fructus Schisandrae Chinensis 3.5g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 10 times of water gagings for the first time, extracted 4 hours, and added 6 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, 40 ℃ the time, being concentrated into proportion is 1.30 with extracting solution, adds ethanol, stir, sealing was placed 6 days, filtered, add simple syrup in the filtrate, and be adjusted in right amount, promptly with distilled water.
Embodiment 12
A. get Fructus Lycii 80g, Semen Cuscutae 48g, Fructus Rubi 48g, processed with salt Semen Plantaginis 20g, 6g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 5 times of water gagings for the first time, extracted 2.5 hours, and added 5 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, 50 ℃ the time, being concentrated into proportion is 1.05 with extracting solution, adds ethanol, stir, sealing was placed 2 days, filtered, add simple syrup in the filtrate, and be adjusted in right amount, promptly with distilled water.
Embodiment 13
A. get Fructus Lycii 80g, Semen Cuscutae 60g, Fructus Rubi 50g, processed with salt Semen Plantaginis 18g, 10g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 8 times of water gagings for the first time, extracted 3 hours, and added 6 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, 70 ℃ the time, being concentrated into proportion is 1.15 with extracting solution, adds ethanol, stir, sealing was placed 1 day, filtered, add simple syrup in the filtrate, and be adjusted to 2350ml, promptly with distilled water.
Embodiment 14
A. get Fructus Lycii 43.5g; Semen Cuscutae 27.4g; Fructus Rubi 17.5g; Semen Plantaginis 7.4g; Fructus Schisandrae Chinensis 4.2g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 5 times of water gagings for the first time, extracted 1 hour, and added 5 times of water gagings for the second time, extracted 1 hour, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 1 day, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 15
A. get Fructus Lycii 34.9g; Semen Cuscutae 34.7g; Fructus Rubi 25.3g; Semen Plantaginis 2.6g; Fructus Schisandrae Chinensis 2.5g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 10 times of water gagings for the first time, extracted 5 hours, and added 10 times of water gagings for the second time, extracted 5 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 4 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 16
A. get Fructus Lycii 80g; Semen Cuscutae 60g; Fructus Rubi 40g; Semen Plantaginis 15g; Fructus Schisandrae Chinensis 5g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 8 times of water gagings for the first time, extracted 3 hours, and added 8 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 1 day 7, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 17
A. get Fructus Lycii 70g; Semen Cuscutae 60g; Fructus Rubi 50g; Semen Plantaginis 15.2g; Fructus Schisandrae Chinensis 4.8g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 6 times of water gagings for the first time, extracted 2 hours, and added 5 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed more than 1 day, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 18
A. get Fructus Lycii 72g; Semen Cuscutae 52g; Fructus Rubi 52.4g; Semen Plantaginis 15.6g; Fructus Schisandrae Chinensis 8g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 9 times of water gagings for the first time, extracted 4 hours, and added 8 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 1 day, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 19
A. get Fructus Lycii 80g; Semen Cuscutae 71.2g; Fructus Rubi 39g; Semen Plantaginis 15.8g; Fructus Schisandrae Chinensis 4g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 10 times of water gagings for the first time, extracted 3 hours, and added 10 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 3 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 20
A. get Fructus Lycii 76g; Semen Cuscutae 58g; Fructus Rubi 44g; Semen Plantaginis 16g; Fructus Schisandrae Chinensis 6g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 6 times of water gagings for the first time, extracted 2 hours, and added 6 times of water gagings for the second time, extracted 1 hour, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 2 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 21
A. get Fructus Lycii 73.4g, Semen Cuscutae 56.2g, Fructus Rubi 45.8g, processed with salt Semen Plantaginis 16.6g, 8g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 9 times of water gagings for the first time, extracted 4 hours, and added 6 times of water gagings for the second time, extracted 2.5 hours, the medicinal residues squeezing filters, and gets extracting solution, 45 ℃ the time, being concentrated into proportion is 1.10 with extracting solution, adds ethanol, stir, sealing was placed 1.5 days, filtered, add simple syrup in the filtrate, and be adjusted to 3000ml, promptly with distilled water.
Embodiment 22
A. get Fructus Lycii 88g, Semen Cuscutae 56.4g, Fructus Rubi 35g, Semen Plantaginis 15.4g, Fructus Schisandrae Chinensis 6.2g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 7 times of water gagings for the first time, extracted 2 hours, and added 5 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, 65 ℃ the time, being concentrated into proportion is 1.20 with extracting solution, adds ethanol, stir, sealing was placed 7 days, filtered, add simple syrup in the filtrate, and be adjusted to 2500ml, promptly with distilled water.
Embodiment 23
A. get Fructus Lycii 80.8g, Semen Cuscutae 60.6g, Fructus Rubi 40.6g, Semen Plantaginis 17g, Fructus Schisandrae Chinensis 1g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 8 times of water gagings for the first time, extracted 3 hours, and added 5 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, 75 ℃ the time, being concentrated into proportion is 1.15 with extracting solution, adds ethanol, stir, sealing was placed 5 days, filtered, add simple syrup in the filtrate, and be adjusted to 2350ml, promptly with distilled water.
Embodiment 24
A. get Fructus Lycii 75g; Semen Cuscutae 58.4g; Fructus Rubi 41.6g; Semen Plantaginis 16.6g; Fructus Schisandrae Chinensis 8.4g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 8 times of water gagings for the first time, extracted 3 hours, and added 5 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, 80 ℃ the time, being concentrated into proportion is 1.15 with extracting solution, adds ethanol, stir, sealing was placed 4 days, filtered, add simple syrup in the filtrate, and be adjusted to 2350ml, promptly with distilled water.
Embodiment 25
A. get Fructus Lycii 72.2g; Semen Cuscutae 64.8g; Fructus Rubi 37.6g; Semen Plantaginis 17g; Fructus Schisandrae Chinensis 8.4g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 7 times of water gagings for the first time, extracted 4 hours, and added 5 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 3 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 26
A. get Fructus Lycii 72g; Semen Cuscutae 56g; Fructus Rubi 40g; Semen Plantaginis 16g; Fructus Schisandrae Chinensis 8g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 8 times of water gagings for the first time, extracted 3 hours, and added 5 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, 60 ℃ the time, being concentrated into proportion is 1.15 with extracting solution, adds ethanol, stir, sealing was placed 2 days, filtered, add simple syrup in the filtrate, and be adjusted to 2350ml, promptly with distilled water.
Embodiment 27
A. get Fructus Lycii 87g, Semen Cuscutae 56.5g, Fructus Rubi 36g, processed with salt Semen Plantaginis 15g, 7g is standby for the processed with wine Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 10 times of water gagings for the first time, extracted 5 hours, and added 10 times of water gagings for the second time, extracted 5 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 1 day, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 28
A. get Fructus Lycii 70g; Semen Cuscutae 56.2g; Fructus Rubi 50.6g; Semen Plantaginis 14.8g; Fructus Schisandrae Chinensis 8.4g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 6.5 times of water gagings for the first time, extracted 1 hour, and added 5.5 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 2.5 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 29
A. get Fructus Lycii 79.8g; Semen Cuscutae 69.4g; Fructus Rubi 35g; Semen Plantaginis 14.8g; Fructus Schisandrae Chinensis 1g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 7.5 times of water gagings for the first time, extracted 3.5 hours, and added 5 times of water gagings for the second time, extracted 1 hour, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 7 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 30
A. get Fructus Lycii 80g; Semen Cuscutae 60g; Fructus Rubi 36g; Semen Plantaginis 16g; Fructus Schisandrae Chinensis 8g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 7 times of water gagings for the first time, extracted 4 hours, and added 5 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 5 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 31
A. get Fructus Lycii 82g; Semen Cuscutae 57g; Fructus Rubi 38g; Semen Plantaginis 17g; Fructus Schisandrae Chinensis 6g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 7 times of water gagings for the first time, extracted 4 hours, and added 8 times of water gagings for the second time, extracted 1 hour, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 2 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 32
A. get Fructus Lycii 75.6g; Semen Cuscutae 54.4g; Fructus Rubi 44.6g; Semen Plantaginis 17g; Fructus Schisandrae Chinensis 8.4g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 5 times of water gagings for the first time, extracted 4 hours, and added 5 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 2 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 33
A. get Fructus Lycii 81g; Semen Cuscutae 61.4g; Fructus Rubi 37.6g; Semen Plantaginis 16g; Fructus Schisandrae Chinensis 4g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 9 times of water gagings for the first time, extracted 2 hours, and added 5 times of water gagings for the second time, extracted 1 hour, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 5 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 34
A. get Fructus Lycii 75g; Semen Cuscutae 58.4g; Fructus Rubi 41.6g; Semen Plantaginis 16.6g; Fructus Schisandrae Chinensis 8.4g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 6.5 times of water gagings for the first time, extracted 2.5 hours, and added 5 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing was placed 2 days, filtered, and added simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
Embodiment 35
A. get Fructus Lycii 73.4g, Semen Cuscutae 56.2g, Fructus Rubi 45.8g, Semen Plantaginis 16.6g, Fructus Schisandrae Chinensis 8g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 6 times of water gagings for the first time, extracted 2 hours, and added 6 times of water gagings for the second time, extracted 1.5 hours, the medicinal residues squeezing filters, and gets extracting solution, 45 ℃ the time, being concentrated into proportion is 1.10 with extracting solution, adds ethanol, stir, sealing was placed 2 days, filtered, add simple syrup in the filtrate, and be adjusted to 3000ml, promptly with distilled water.
Embodiment 36
A. get Fructus Lycii 87g, Semen Cuscutae 56.4g, Fructus Rubi 35g, Semen Plantaginis 14.4g, Fructus Schisandrae Chinensis 6.2g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 8 times of water gagings for the first time, extracted 3 hours, and added 5 times of water gagings for the second time, extracted 2 hours, the medicinal residues squeezing filters, and gets extracting solution, 75 ℃ the time, being concentrated into proportion is 1.25 with extracting solution, adds ethanol, stir, sealing was placed 2 days, filtered, add simple syrup in the filtrate, and be adjusted to 2500ml, promptly with distilled water.
Embodiment 37
A. get Fructus Lycii 80.8g, Semen Cuscutae 60.6g, Fructus Rubi 40.6g, Semen Plantaginis 17g, Fructus Schisandrae Chinensis 1g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 9 times of water gagings for the first time, extracted 3 hours, and added 6 times of water gagings for the second time, extracted 2.5 hours, the medicinal residues squeezing filters, and gets extracting solution, 60 ℃ the time, being concentrated into proportion is 1.25 with extracting solution, adds ethanol, stir, sealing was placed 1 day, filtered, add simple syrup in the filtrate, and be adjusted to 1350ml, promptly with distilled water.
Embodiment 38
A. get Fructus Lycii 87g, Semen Cuscutae 56.4g, Fructus Rubi 35g, Semen Plantaginis 14.4g, Fructus Schisandrae Chinensis 6.2g is standby;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 5.5 times of water gagings for the first time, extracted 2 hours, and added 5 times of water gagings for the second time, extracted 1 hour, the medicinal residues squeezing filters, and gets extracting solution, 80 ℃ the time, being concentrated into proportion is 1.10 with extracting solution, adds ethanol, stir, sealing was placed 3 days, filtered, add simple syrup in the filtrate, and be adjusted to 1550ml, promptly with distilled water.
Claims (10)
1. the Chinese medicine composition of a benefiting essence and marrow, boosting kidney and strengthening yang is characterized in that it is to be made by following weight proportion crude drug: Fructus Lycii 35.0%～43.5%; Semen Cuscutae 25.1%～34.5%; Fructus Rubi 17.5%～25.3%; Semen Plantaginis 0.1%～8.5%; Fructus Schisandrae Chinensis 0.1%～4.2%.
2. Chinese medicine composition as claimed in claim 1 is characterized in that it is to be made by following weight proportion crude drug: Fructus Lycii 35.9%～40.5%; Semen Cuscutae 27.2%～32.4%; Fructus Rubi 18.8%～22.3%; Semen Plantaginis 7.9%～8.5%; Fructus Schisandrae Chinensis 2%～4.2%.
3. Chinese medicine composition as claimed in claim 1 is characterized in that it is to be made by following weight proportion crude drug: Fructus Lycii 37.5%; Semen Cuscutae 29.2%; Fructus Rubi 20.8%; Semen Plantaginis 8.3%; Fructus Schisandrae Chinensis 4.2%.
4. Chinese medicine composition as claimed in claim 1 is characterized in that it is to be made by following weight proportion crude drug: Fructus Lycii 36.7%, Semen Cuscutae 28.1%, Fructus Rubi 22.9%, Semen Plantaginis 8.3%, Fructus Schisandrae Chinensis 4.0%.
5. Chinese medicine composition as claimed in claim 1 is characterized in that it is to be made by following weight proportion crude drug: Fructus Lycii 43.5%, Semen Cuscutae 28.2%, Fructus Rubi 17.5%, Semen Plantaginis 7.7%, Fructus Schisandrae Chinensis 3.1%.
6. Chinese medicine composition as claimed in claim 1 is characterized in that it is to be made by following weight proportion crude drug: Fructus Lycii 40.4%, Semen Cuscutae 30.3%, Fructus Rubi 20.3%, Semen Plantaginis 8.5%, Fructus Schisandrae Chinensis 0.5%.
7. as the arbitrary described Chinese medicine composition of claim 1～6, it is characterized in that Semen Plantaginis is the processed with salt Semen Plantaginis; Fructus Schisandrae Chinensis is the processed with wine Fructus Schisandrae Chinensis.
8. as the preparation method of the arbitrary described Chinese medicine composition of claim 1～6, it is characterized in that:
A. it is standby to get Fructus Lycii, Semen Cuscutae, Fructus Rubi, Semen Plantaginis, Fructus Schisandrae Chinensis;
B. the above five tastes are put the interior water extraction of extraction pot 2 times, add 5～10 times of water gagings for the first time, extracted 1～5 hour, and added 5～10 times of water gagings for the second time, extracted 1～5 hour, the medicinal residues squeezing filters, and gets extracting solution, extracting solution is concentrated, add ethanol, stir, sealing is placed, and filters, and adds simple syrup in the filtrate, and be adjusted in right amount with distilled water, promptly.
9. the preparation method of Chinese medicine composition as claimed in claim 8 is characterized in that: among the step b, seal and place more than 1 day; Concentrated solution is in the time of 40～80 ℃, and being concentrated into proportion is 1.00～1.30.
10. the preparation method of Chinese medicine composition as claimed in claim 8 is characterized in that: among the step b, seal and placed 1～7 day; Concentrated solution is in the time of 50～70 ℃, and being concentrated into proportion is 1.05～1.25.
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| CN111450171A (en) * | 2020-02-27 | 2020-07-28 | 佛山手心制药有限公司 | Wuzi Yanzong soft capsule and preparation method thereof |
| CN111450171B (en) * | 2020-02-27 | 2021-10-22 | 佛山手心制药有限公司 | Wuzi Yanzong soft capsule and preparation method thereof |
| CN111419946A (en) * | 2020-04-28 | 2020-07-17 | 广东三蓝药业股份有限公司 | Medicine for treating infertility and preparation method thereof |
| CN115645485A (en) * | 2022-11-22 | 2023-01-31 | 海南中希医疗科技有限公司 | Traditional Chinese medicine preparation for promoting inoculation |
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