CN101507776A - Traditional Chinese medicine preparation for treating kidney deficiency, waist and knees soreness and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal preparation for treating kidney deficiency and lassitude in loin and legs and a preparation method thereof. The Chinese medicinal preparation comprises the following compositions in portion by weight: 10 to 30 portions of ginseng, 10 to 30 portions of semen plantaginis, 10 to 30 portions of Eclipta alba, 10 to 30 portions of Astragalus membranaceus, 10 to 30 portions of Chinese angelica, 10 to 30 portions of Chinese dodder seeds, 10 to 30 portions of broomrape, 10 to 30 portions of raspberry, 10 to 30 portions of prepared rehmannia rhizome, 10 to 30 portions of frutus cnidii, 10 to 30 portions of prepared Polygonum multiform, 10 to 30 portions of black sesame seeds, 10 to 30 portions of epimedium, 10 to 30 portions of cistanche deserticola, 10 to 30 portions of raw oyster, 10 to 30 portions of male silkworm moth, 10 to 30 portions of cinnamon, 10 to 30 portions of Schisandra chinensis and 10 to 30 portions of red sage root. The Chinese medicinal preparation has the functions of nourishing liver, invigorating spleen and tonifying kidney, benefiting vital energy and enriching the blood, and nourishing yin and kidney, and has obvious functions of treating and improving kidney-Yang deficiency symptoms such as the lassitude in loin and legs, intolerance of cold and impotence and premature ejaculation caused by the kidney deficiency. In addition, the Chinese medicinal preparation is economic and practical, has simple preparation method, and can achieve good economic benefits.

Description

A kind of treatment is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees and preparation method thereof

Technical field

The present invention relates to contain the medical preparation that derives from plant, animal or mineral component, particularly a kind of treatment is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees and preparation method thereof.

Background technology

Chinese medicine thinks that kidney storing essence is a congenital foundation.Kidney master growth, growth and reproduction, main bone are given birth to marrow and are led in brain, and brain is the place of marrow and gods high concentration, and all thinking activitiess of people are all by the brain domination, and " interior warp " says " the living then marrow of kidney is discontented ".The essence of kidney is the source of people's life activity, be the base substance that constitutes human body, smart energy activating QI, gas energy spermatogenesis, kidney spermatogenesis, smart hemopoietic, oligospermia be disease then, essence is then died to the greatest extent, the essence gas that declines is then weak, and smart sufficient gas is then strong, weakness of QI also then a little less than, arrogant blood is then prosperous, qi being the governor of blood, blood being the material foundation of QI, visible essence, gas, blood are mutual dependence for existencies.Cloudy essence is that yang-energy is basic.Yang transforming qi, yin shaping up body, cloudy smart and blood homology, as the shape of depletion of YIN essence, just be not enough to carry a yang-energy, so sun is born in the life of thing; The one-tenth of thing is formed in the moon, has only cloudy smart abundance, and yang-energy is vigorous, and the two coordinated balance, and human body could be healthy.

The kidney being the origin of congenital constitution, is the root of human body reproductive development, the motive power of internal organs functional activity, and the vital essence of kidney can be divided into kidney yin, kidney yang two aspects from effect, and kidney yin and kidney yang mutual dependence for existence, mutual restriction are kept the dynamic equilibrium of human body.After this balance is destroyed, the pathological change that will occur that kidney yin, kidney yang decline partially or contain partially, decline partially as kidney yin and can not make sun, the pathological changes that hyperactivity of YANG due to deficiency of YIN just occurs, it is deficiency of the kidney yin, show as the performances such as premature ejaculation, woman's infrequent menstruation amenorrhea, constipation, the few tongue thready and rapid pulse of red tongue of passing out semen of soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, dizziness and tinnitus, insomnia forgetfulness, night sweat, man.Kidney yang declines partially then and to be insufficiency of kidney-YANG, shows as pale complexion or dark, cold, the lassitude of waist knee joint acid, and the impotence in male premature ejaculation, is had loose bowels etc. just before dawn at woman's infertility, enuresis edema.From these symptoms, suffer from a deficiency of the kidney and not only show as the change of sexual function aspect, also comprising a series of variations of whole body, therefore the accent of kidney is mended and in the human life activity, occupied very important position.If congenital defect will lose and support the day after tomorrow, or prolonged illness consumption wound, kidney store essential substances deficiency, " water loses its source, and then the disease of the deficiency of YIN is folded out on the one hand; Fire declines it, then yang deficiency levy storied." can not go up as suffering from a deficiency of the kidney warm in the heart, fill in brain will occur cardiopalmus, uncomfortable in chest, breathe hard, insomnia and dreamful sleep, dizziness headache, forgetful.QI and bloodization is given birth to obstacle menoxenia, pachylosis will occur.Hectic fever, flushed face in the afternoon will appear in the imbalance of YIN and YANG of kidney, sore waist and aching in the waist and the back, sexual hypofunction and climacteric syndrome etc.

" kidney " of the traditional Chinese medical science and the kidney on the doctor trained in Western medicine anatomy are diverse, and the kidney of doctor trained in Western medicine is a pair of organ on the anatomy, and its major function is to filter the metabolite of draining body, keeps body water liquid, electrolytical balance, the blood volume of remaining valid." kidney " of the traditional Chinese medical science is not a concrete histoorgan, but the system that integrates out according to certain function, and the traditional Chinese medical science is thought " kidney storing essence, main bone is given birth to marrow, main water liquid, main improving inspiration by invigorating kidney-QI is had one's ideas straightened out in ear and two the moon ".And " kidney storing essence ", be again the prerequisite and the basis of all functional activities of the traditional Chinese medical science " kidney ", its function is equivalent to the function of skeleton in urinary system, reproductive system, nervous system, hormonal system, hemopoietic system and the motor system of doctor trained in Western medicine or the like, with " essence " is tie, utilization traditional Chinese medical science yin-yang and five elements, organic conception theory are organically got up these interconnections, therefore, " kidney " of the traditional Chinese medical science is the kidney on the functional meaning, be the comprehensive four diagnostic methods (hope, hear, ask, cut) data, on material base, discern according to the traditional Chinese medical science " dialectical " theory.Therefore, " kidney " of the traditional Chinese medical science has omnibearing regulatory function to human body, and the major physiological function has several aspects: improve immunity, promote growth, growth and the reproduction of body, regulate the metabolism and the physiological function activity of body.

The treatment of suffering from a deficiency of the kidney mainly is divided into the treatment of deficiency of the kidney yin on the traditional Chinese medical science, the treatment of insufficiency of kidney-YANG and the treatment of deficiency of both YIN and YANG.In treatment, mainly can be divided into several, i.e. Drug therapy, movement technique treatment, and dietetic therapy.The three respectively has pluses and minuses.But generally speaking, which kind of method all will be carried out dialectical to suffering from a deficiency of the kidney, and just branch is understood the deficiency of YIN, yang deficiency, still is deficiency of both YIN and YANG, carries out concrete treatment as the case may be.The kidney invigorating needs forked rubbing: the traditional Chinese medical science is particular about diagnosis and treatment based on an overall analysis of the illness and the patient's condition, suits the remedy to the case, and the kidney invigorating need be distinguished negative and positive, is regardless of deficiency of YIN yang deficiency, abuses tonic, not only health is not had benefit, and may damage.

Generally, deficiency of the kidney yin mainly shows as dysphoria with feverish sensation in the chest palms and soles, dizziness and tinnitus, soreness of the waist and knees exactly on symptom, osteopyrexia and fever, hectically flushed cheeks, dry mouth and tougue, night sweat seminal emission, the symptom of interior-heat caused by deficiency of YIN such as the few tongue of red tongue, this time is the most suitable takes the LIUWEI DIHUANG WAN that we are familiar with.Insufficiency of kidney-YANG then shows as chills and pain of the waist and kness more on symptom aching and limp, cold extremities with aversion to cold, and especially waist is always worn two clothes than others to issue cold at ordinary times, nocturia, neurolysis, sexual impotence, edema, clear urine in large amounts, incontinence or unfavorable, the symptom of yang deficiency endogenous cold such as pale tongue.There are these situations to select for use to be used for specially treating compound recipe male moth Yiyang capsule (oral liquid) of insufficiency of kidney-YANG, JINGUI SHENQI WAN etc., they are classic prescriptions of warming and recuperating the kidney-YANG.

The present invention suits the remedy to the case at insufficiency of kidney-YANG exactly.Suffer from a deficiency of the kidney and generally be meant with the deficiency of kidney-essence to be syndromes such as center and the deficiency of kidney-QI that causes therefrom, deficiency of the kidney yin, insufficiency of kidney-YANG.Various symptoms show as: 1. deficiency of kidney-essence: brains inanition, the hypophrenia, forgetful, insomnia, lusterless complexion, order week blackout, heavy, weakness of the lower extremities (or it is weak to wither), soreness of the waist and knees, geromorphism, sexual impotence, lingering diarrhea, teenager be hypoevolutism and children's's five kinds of growth retardation five kinds of flaccidity in infant etc. then; 2. deficiency of kidney-QI: deficient in energyly, quiet then think to sleep, two orders are unable, soreness of the waist and knees, easy to catch cold, seminal emission, spermatorrhea or moving then asthma, incontinence of feces, clear urine in large amounts or the enuresis, frequent micturition, acraturesis (or not smooth), the heeltap even incontinence of urination and defecation etc. are arranged; 3 deficiency of the kidney yin: emaciated physique, dysphoria with feverish sensation in the chest palms and soles, thirsty and dry pharynx (or pharynx is painful repeatedly), osteopyrexia and fever, flushed cheeks, night sweat, Hiccough and deaf, the soreness of waist (ache), yellowish or reddish urine, red tongue tongue, deficient pulse are less counted accurately etc.; 4. insufficiency of kidney-YANG: be afraid of cold, the limb cold, easily have a cold or hyperhidrosis, inappetence, sexual impotence, essence (palace) cold sterile, have loose bowels just before dawn or dysuria even edema, waist are coldly ached, light red tongue or fat indentation, deep-slow pulse etc. are arranged greatly.

It is pointed out that various suffering from a deficiency of the kidney is the center with the kidney-jing deficiency all, so the performance of deficiency of kidney-essence is among various suffering from a deficiency of the kidney on the one hand; On the other hand, owing to be subjected to the influence of various factors, specifically everyone performance is again so that wherein one or more are cardinal symptom.At present " suffering from a deficiency of the kidney " of often saying gone up by society, as seminal emission, sexual impotence, premature ejaculation, hyposexuality, sterile, infertile etc., is actually suffering from a deficiency of the kidney of narrow sense.Sensu lato suffering from a deficiency of the kidney comprises a series of General Symptoms.The symptom of suffering from a deficiency of the kidney is utilized modern instrument to detect and is often come to nothing, and doctor trained in Western medicine also can only also be felt simply helpless to its treatment from Subhealth treating.And,, can not satisfy various patients' demand no matter be that formula components various aspects from traditional Chinese medical science mechanism, dosage form or the medicine of institute's foundation all do not have bigger breakthrough for the traditional Chinese medical science.

Summary of the invention

Technical problem to be solved by this invention is, provide that a kind of treatment is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees and preparation method thereof, remain in many deficiencies at the present treatment medicine of suffering from a deficiency of the kidney, can't definitely diagnose and treat as doctor trained in Western medicine, it is main can only nursing one's health human body sub-health status, and the cycle is long, and expense is big, uncertain therapeutic efficacy is cut, and also is difficult for adhering to; Traditional Chinese medical science traditional therapy is also nothing more than symptomatic treatment in acute condition, rules such as relieving the primary symptom in a chronic case, and that tests is clinical, though certain curative effect is arranged, produces effects slowly, and effective percentage is low.

For solving above-mentioned technical barrier, it is simple to the invention provides a kind of prescription, the treatment that processing technology is easy is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees, the ratio of weight and number of various components is in the described preparation: 10～30 parts of Radix Ginsengs, 10～30 parts of Semen Plantaginiss, 10～30 parts of Herba Ecliptaes, 10～30 parts of the Radixs Astragali, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Semen Cuscutae, 10～30 parts of Herba Orobanchess, 10～30 parts of Fructus Rubies, 10～30 parts in Radix Rehmanniae Preparata, 10～20 parts of Fructus Cnidiis, 10～30 parts of Radix Polygoni Multiflori Preparata, 10～30 parts of Semen Sesami Nigrums, 10～30 parts of Herba Epimedii, 10～30 parts of Herba Cistanches, 10～30 parts of Concha Ostreae, 10～30 parts of male Bombycis mori, 10～30 parts of Cortex Cinnamomis, 10～30 parts of Fructus Schisandrae Chinensis, 10～30 parts of Cortex Moutans.

Described treatment is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees, the ratio of weight and number of various components can be preferably in the described preparation: 10～15 parts of Radix Ginsengs, 10～15 parts of Semen Plantaginiss, 10～15 parts of Herba Ecliptaes, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Semen Cuscutae, 10～15 parts of Herba Orobanchess, 10～20 parts of Fructus Rubies, 10～20 parts in Radix Rehmanniae Preparata, 10～15 parts of Fructus Cnidiis, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Semen Sesami Nigrums, 10～20 parts of Herba Epimedii, 10～20 parts of Herba Cistanches, 10～20 parts of Concha Ostreae, 10～20 parts of male Bombycis mori, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Cortex Moutans.

Described treatment is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees, the ratio of weight and number of various components can also be preferably in the described preparation: 10～20 parts of Radix Ginsengs, 10～20 parts of Semen Plantaginiss, 10～20 parts of Herba Ecliptaes, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Semen Cuscutae, 10～20 parts of Herba Orobanchess, 10～15 parts of Fructus Rubies, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Fructus Cnidiis, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Semen Sesami Nigrums, 10～15 parts of Herba Epimedii, 10～15 parts of Herba Cistanches, 10～15 parts of Concha Ostreae, 10～15 parts of male Bombycis mori, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts of Cortex Moutans.

Described treatment is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees, the ratio of weight and number of various components also can be preferably in the described preparation: 20～30 parts of Radix Ginsengs, 20～30 parts of Semen Plantaginiss, 20～30 parts of Herba Ecliptaes, 20～30 parts of the Radixs Astragali, 20～30 parts of Radix Angelicae Sinensis, 20～30 parts of Semen Cuscutae, 20～30 parts of Herba Orobanchess, 20～30 parts of Fructus Rubies, 20～30 parts in Radix Rehmanniae Preparata, 10～20 parts of Fructus Cnidiis, 20～30 parts of Radix Polygoni Multiflori Preparata, 20～30 parts of Semen Sesami Nigrums, 20～30 parts of Herba Epimedii, 20～30 parts of Herba Cistanches, 20～30 parts of Concha Ostreae, 20～30 parts of male Bombycis mori, 20～30 parts of Cortex Cinnamomis, 20～30 parts of Fructus Schisandrae Chinensis, 20～30 parts of Cortex Moutans.

Described treatment is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees, and described medicine is fried in shallow oil decoction in use and taken, can every day 1 dose, and decocting is obeyed at twice, and per 30 days is a course of treatment.

Described treatment is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees, and described pharmaceutical dosage form can be honey refining pill, hydration pill, capsule, oral liquid, granule, colloid or syrup.

For solving the problems of the technologies described above, the present invention provides also that a kind of treatment is suffered from a deficiency of the kidney, the preparation method of the Chinese medicine preparation of soreness of the waist and knees, and described Chinese medicine preparation dosage form is a honey refining pill, and its preparation method comprises: described component is put into the above Chinese liquor of 60 degree soaked 10～15 days, filter filtrate for later use; Filtering residue added water boil 30～40 minutes, filtered filtrate for later use; Filtering residue adds water again, and heated and boiled is 30～40 minutes for the second time, refilters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, and postcooling is dried in 70 ℃～80 ℃ oven dry, and mixing with Mel is twisted into slice; With 5g is ball wax seal packing.

For solving the problems of the technologies described above, the present invention provides again that a kind of treatment is suffered from a deficiency of the kidney, the preparation method of the Chinese medicine preparation of soreness of the waist and knees, described Chinese medicine preparation dosage form is a capsule, its preparation method comprises: described component is added 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times each 2 hours, merges 3 extracting solution, decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, sucking filtration to the relative density of filtrate is 1.06; With aforementioned filtrate flow is the macroporous adsorptive resins of 10L through volume, use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule, every capsules dress 0.4g.

For solving the problems of the technologies described above, the present invention provides a kind of treatment to suffer from a deficiency of the kidney again, the preparation method of the Chinese medicine preparation of soreness of the waist and knees, described Chinese medicine preparation dosage form is a granule, its preparation method comprises: described component is mixed by proportioning, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures and pressures, flooded 10～20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, and heating is concentrated into pasty state, put into baking oven, 80 ℃ of oven dry, the oven dry postcooling is pulverized the back and is added the starch mixing, granulate, dry, granulate, packing, every bag of 4～6g packing.

For solving the problems of the technologies described above, the present invention provides also that a kind of treatment is suffered from a deficiency of the kidney, the preparation method of the Chinese medicine preparation of soreness of the waist and knees, described Chinese medicine preparation dosage form is a tablet, its preparation method comprises: described component is mixed by proportioning, drop into pulverizer and be ground into fine powder, after sieving, puts into fine powder the acid and alkali-resistance infusion kettle, at normal temperatures and pressures, with common the dipping 10～20 days of the above Chinese liquor of 60 degree, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, and heating is concentrated into pasty state, add starch and mix, dry, tabletting.

Advantages such as compared with prior art, present technique has convenient drug administration, and medicament is easy to make, and is with low cost.The present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect, and safety, and is without any side effects, easy to use, and healing time is short, and is evident in efficacy.Can create good social is worth and economic interests.

The specific embodiment

Sensu lato suffering from a deficiency of the kidney comprises a series of General Symptoms.The traditional Chinese medical science is said suffers from a deficiency of the kidney and the sub-health state of doctor trained in Western medicine approval quite has similarity.Patient that one, majority are suffered from a deficiency of the kidney and subhealth state patient can't distinguish their Symptomatic similaritys when going to a doctor.Its two, their definition is all very abstract, all is to determine with a pile symptom.Difference is, the notion of suffering from a deficiency of the kidney is of long duration, and some organic diseases are often also listed in wherein.It is multiple to have suffered from a deficiency of the kidney, the most common with deficiency of the kidney yin, insufficiency of kidney-YANG.Suffering from a deficiency of the kidney of traditional Chinese medical science indication has many types, and wherein modal is deficiency of the kidney yin, insufficiency of kidney-YANG.Deficiency of the kidney yin shows as symptoms such as dry mouth and tougue, skin pruritus, insomnia and dreamful sleep, mood agitation, soreness of waist and knee, feverish sensation in the palms and soles, tinnitus dizziness.In addition, performances such as constipation, infrequent menstruation even amenorrhea can appear in the woman.Insufficiency of kidney-YANG shows as that pale complexion or pitch-dark, waist knee joint ache, lassitude, brothers are ice-cold, fear of cold aversion to wind, diarrhoea, edema of the body etc.In addition, symptoms such as infertile, the enuresis, edema, hyposexuality can appear in the woman.The kidney of the kidney of traditional Chinese medical science indication and modern medicine indication is not same thing youngster, and suffering from a deficiency of the kidney not is renal failure, negative and positive of qi and blood weakness just, can't be as renal failure be so serious threat to life.Person who suffer from deficiency of kidney Yang must be paid attention to the kidney invigorating, but can not disorderly mend.Theory of Chinese medical science is thought, kidney controlling essence storage.Essence is the base substance that constitutes human life, also is the material base of the various functional activities of the growth promoter vital organs of the human body.The kidney essense abundance is then hale and hearty, and vital organs of the human body function is normal, suffers from a deficiency of the kidney then that vitality weakens, and various diseases will attack gradually.Therefore, effect a radical cure these slight illness, thoroughly improve health, must start with from the kidney invigorating.Can not blindly mend but suffer from a deficiency of the kidney, disorderly benefit does harm rather than good.

Traditional Chinese medical science the kidney invigorating understands fully that earlier deficiency of the kidney yin, insufficiency of kidney-YANG or deficiency of kidney-QI are crucial.In general, the most flush crimson of deficiency of the kidney yin person, dysphoria with feverish sensation in the chest palms and soles.Mostly the medicine of the kidney invigorating deficiency of YIN is sweet cold medicine, and as Herba Dendrobii, Rhizoma Polygonati Odorati, Fructus Corni, Semen Sesami Nigrum, Radix Panacis Quinquefolii etc., the representative of Chinese patent medicine is a LIUWEI DIHUANG WAN.Yang deficiency person then is afraid of cold, coolness of extremities, pale complexion.Mostly the kidney invigorating yang deficiency medicine is hot medicine, and as Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Cornu Cervi Pantotrichum etc., the representative of Chinese patent medicine is a JINGUI SHENQI WAN.Tonify deficiency is accomplished reinforcing and reducing concurrently as law.Liver and kidney belongs to cloudy, and spleen also belongs to the moon.The spleen being the foundation of acquired constitution is also worked as tonification, to strengthen the power of its fortuneization.This three cloudy benefit together is that " strengthening renal yin to inhibit predominant yang is with system sunlight." invigorating middle warmer has and rush down, it is turbid then can to lead kidney off, pancake liver-fire, and the stagnate drawback of spleen of the greasy stomach of drugs for nourishing yin is removed in the eliminating dampness by diuresis spleen invigorating.Moreover, the QI invigorating in the ban of enriching blood.Because of qi being the governor of blood, blood being the material foundation of QI, gas are the son of blood, and the capable then blood of gas is capable.Selected QI invigorating medicine in the event side is realized qi and blood tonifying.Yet patients with vitiligo, nephroyin and nephroyang loses to hinder and weighs mostly, and only suitable even reinforcing-reducing method can not be mended high rushing down suddenly.When be slow mend and in, become empty and lose to substantial." following the law of YIN YANG will bring about a benificial consequence, violating the law of YIN YANG will bring a harmful consequence in a word." what the present invention is directed to is exactly the various symptoms of insufficiency of kidney-YANG.

The present invention mainly sets about from endogenous cause of ill, selected medical material, science compatibility.In the prescription of the present invention, medicines such as Radix Ginseng, Radix Rehmanniae Preparata, Herba Epimedii, Semen Sesami Nigrum, Herba Cistanches have immunoregulatory effect through modern medicine study.Both can benefiting vital QI and blood by full side's compatibility, directly strengthen and defend airway dysfunction, again can the replenishing essence the kidney invigorating, make that yang-energy fills Sheng in the kidney, yang-energy is defend gas basic in the kidney, and kidney qi is filled Sheng Zewei gas and is also filled Sheng, and the ability of resisting exopathogen also strengthens.Working along both lines in two aspects, brings out the best in each other, and makes medicine have more good effect in treatment and epidemic prevention power aspect low.Use the Radix Ginseng replenishing QI and blood, make kidney get the big benefit of Radix Ginseng and vital essence is more prosperous; Fructus Cnidii, the tonification of Herba Ecliptae yang invigorating; Radix Rehmanniae Preparata, the Semen Sesami Nigrum of big nourishing YIN essence, male Bombycis mori lean marrow, blood-tonifying kidney-nourishing; Radix Angelicae Sinensis, the Radix Astragali QI invigorating that nourishes blood; Herba Epimedii, Herba Cistanches benefit vital essence, fonifying life-gate fire be with YIN and YANG balance regulating, with specially control let out essence, consumptive disease with lumbago Cortex Cinnamomi with controlling nocturnal emission with astringent drugs gas, invigorating the liver and kidney, bright binocular; Semen Cuscutae is in Semen Plantaginis kidney tonifying essence, logical heart kidney, the dormancy of sleeping peacefully, the accent of being amusing; Herba Orobanches, Fructus Rubi nuclear depressed liver-energy dispersing and QI regulating, warming spleen and stomach for dispelling cold, Concha Ostreae mind tranquilizing and the heart calming, Cortex Moutan heat clearing away.Comprehensive full side has YIN and YANG balance regulating, and QI and blood is ruled together, and is not dry oiliness, do not contain hormone, do not hinder the intestines and stomach, protects the liver characteristics such as protecting kidney.

The sweet acid of Herba Ecliptae nature and flavor, removing heat from blood, hemostasis, the kidney invigorating, tonifying YIN.Control haematemesis, hemoptysis, epistaxis, hematuria is had blood in stool, dysentery, knife injury is hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, leukorrhagia, pudendum pruritus due to damp pathogen.Compendium of Material Medica says that it can " black moustache be sent out, kidney tonifying the moon." " book on Chinese herbal medicine justice " think that Herba Ecliptae " goes into the kidney nourishing YIN and the hair of growing.”

Semen Cuscutae Gan Xinping goes into liver, kidney channel.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive.Be used for caused by liver and kidney deficiency, soreness of waist and knee joint, impotence and seminal emission, frequent urination and enuresis, two blurred visions are dark, diseases such as frequent fetal movement.The function tonification Liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal.Being used for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen suffers from a deficiency of the kidney and rushes down.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Radix Ginseng sweet in the mouth, little hardship, tepor is returned spleen, kidney channel, kind strongly invigorating primordial QI, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves.Kind all diseases of the deficiency of vital energy and insomnia forgetfulness, severe palpitation, blood deficiency and yellow complexion, the sexual impotence cold womb controlled." book on Chinese herbal medicine is just " cloud: " Radix Ginseng deficiency of vital energy blood deficiency all can be mended, the deficiency of YANG QI person of exhausting, this can return in the township that has of nothing else; The cloudy blood person of collapsing that bursts, this energy barrier after breaking with.Not hot precisely because gas is strong, so the energy solid and gas; Precisely because sweet in the mouth and pure is so can enrich blood.So all void and generating heat, void and spontaneous perspiration is empty and dizzy, empty and sleepy, empty and be scared, empty and lose heart, void and spermatorrhea, empty and let out profit, void and headache, empty and suffer from abdominal pain, void and desire food is not transported, and void and sputum are stopped up and stagnated, and void and hemoptysis is spitted blood is empty and drench drop and just close, and is all must indispensable person.The desires to compare with QI and blood, and then the Radix Ginseng abnormal smells from the patient is quite light and to belong to positive person many, is the medicine of edema caused by disorder of QI." " book on Chinese herbal medicine converge with speech " " the ginseng qi-tonifying hemopoietic, the medicine that helps intensive culture god also.So vital qi is weak, the very brief deficiency of vital energy is mended it with this, and as the Rong Wei inanition, that uses can control also; The palpitation with fear palpitation with a distress feeling, forgetful in a trance, with this peaceful it; Unit is refreshing not enough, and empty win is unable, trains it with this, falls into as middle weakness of QI, and that uses can rise also.”

Herba Cistanches is sweet, salty, warm, goes into kidney, large intestine channel, the kidney invigorating and essence nourishing, and it is infertile to be apt to control sexual impotence, chills and pain of the waist and kness, muscles and bones is unable, the dryness of the intestine constipation." book on Chinese herbal medicine converges and says " " Herba Cistanches is supported the gate of vitality, nourishing kidney gas, the medicine of replenishing vital essence and blood is also.The red first cold caused by deficiency of man and Yang Dao is heavy for a long time, women's Chong and Ren channel disorder and cloudy gas is not controlled, this is the agent of flat benefits, temperature and not hot is mended and not high, warm and not dry, slides and does not let out." " book on Chinese herbal medicine justice " cloud " kidney man is directly gone in the thick and heavy decline of Herba Cistanches, and the Wen Erneng profit does not have dry strong anxiety, can the replenishing vital QI with drugs of warm nature essence and blood and the gas that activates yang, so say beneficial vital essence.”

Herba Epimedii suffering, sweet, warm is returned liver, kidney channel.The energy reinforcing the kidney and supporting YANG, strengthening the tendons and bones, expelling wind and removing dampness is apt to control insufficiency of kidney-YANG, impotence and seminal emission, enuresis frequent micturition; Rheumatic arthralgia, atrophic debility of bones paralysis disease." book on Chinese herbal medicine is stated " cloud " excessive sheep fire, " herbal classic " medicine master impotence is hindered extremely, the exhausted sun of " solar corona " also first its treatment of speech man, the woman is exhausted cloudy, and then calling the gate of vitality, mending the kidney-Yang person is also.The lid gate of vitality be a kidney-Yang in the kidney, promptly the vigour of the person also, its what is called is YANG exhaustion the moon extremely, the vigour of basis not, how hiss in both withered.So-called physical strength profiting, strong will, and control the cold air consumptive disease, and the anxious card that waits of muscles and bones contraction, all it helps the event of vigour.Old man's dusk octogenarian, the middle age is forgetful, all Yuanyang decay and can not ascensionist also.Must know this flavor to reduce to liter, it rises owing to can fall also.”

The Chinese medicine Radix Polygoni Multiflori has the branch of Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata, and direct slicing is used as medicine and is Radix Polygoni Multiflori, mixes to dry to be used as medicine after the steaming with the Semen sojae atricolor liquor to be Radix Polygoni Multiflori Preparata.The function of the two is different: the detoxifcation of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation are usually used in treating scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening are used for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.

The Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.Be that the benefit fire is supporing yang, let the fire back to its origin, dispersing cold for relieving pain, the good medicine of promoting blood circulation to restore menstrual flow.Be used for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG; Gate of vitality's fire aversion to cold and cold limbs; Soreness of the waist and knees; Impotence and seminal emission; Dysuria or frequency; The dyspnea with rapid and short breath of losing heart; The all cards of edema oliguria; Decline of the fire from the gate of life; Fire is Gui Yuan not; Floating YANG; Refusing yang; And heat in the upper and cold in the lower; The flushed complexion cold foot; Dizziness and tinnitus; Dispute is rotten broken; Spleen-kidney vacuity cold; Coldness and pain in the epigastrium; The decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain; Cold womb is infertile; The dysmenorrhea amenorrhea; The stasis of blood stagnated and suffered from abdominal pain puerperal; The carbuncle of yin nature multiple abscess; Or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus; Or do not hold back after bursting." not Lu " carries it: main pained, side of body wind, hypochondriac pain, warm muscle is promoted blood circulation, end tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago is ended saliva, cough; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, and nothing is feared.

Herba Orobanches is warm in nature, and sweet in the mouth cures mainly, the kidney invigorating, strong muscle.Chills and pain of the waist and kness, impotence and seminal emission, neurosis are used to suffer from a deficiency of the kidney." Kaibao Bencao ": main man's five kinds of strain and seven kinds of impairment, mend the waist kidney, made us son, remove wind blood.

It is sweet that Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata, tepor.Return liver, kidney channel.Function cures mainly nourishing YIN and supplementing blood, and beneficial essence is filled out marrow.Be used for the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair.

Fructus Cnidii suffering, hardship, temperature; Slightly poisonous.Return kidney channel.Cure mainly warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.Be used for sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; The external treatment vulval eczema, married woman's pudendal pruritus; Trichomonal vaginitis is gynecological external use good medicine." Bencao Jingshu " carries: Fructus Cnidii, and bitter in the mouth is flat; " not Lu " be hot sweet nontoxic; Modern detailed its abnormal smells from the patient, when the warm-dryness syndrome of must holding concurrently, sun also.So swell and ache in housewife people's the moon, man's impotence pruritus due to damp pathogen removes stagnated QI, sharp joint, malignant boil." not Lu " warming the middle warmer and descending qi makes married woman's Zifu heat, and the man is cloudy strong, has made us son.Lid can dehumidify with tongue, temperature energy cold expelling, and suffering can be moistened kidney, and sweet energy strengthening the spleen is so can remove the wet disease of viscera connecting with this channel of all deficiency and coldness of married woman man.Cold-damp was both removed, and then disease is gone, performance Yiyang, thus disease, and have tonification also.

The Cortex Moutan bitter in the mouth is slightly cold, can clearing heat in YING system branch, blood system excess-heat, the merit of cooling blood for hemostasis is arranged.Control epidemic febrile disease heat and go into nutrient blood, the absurd row of forcing blood.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again." herbal classic " carries it: " main cold and heat, the apoplexy contract is removed hard disease blood stasis and is stayed the house the intestines and stomach from, convulsion, infantile convulsion pathogen, and settling five organs is treated the carbuncle skin ulcer.

The male Bombycis mori male Bombycis mori eat in state-owned long history, just be considered as a kind of tonic of preciousness by imperial family as far back as Tang and Song Dynasty time.Ming Dynasty's Li Shizhen (1518-1593 A.D.) is held sway over a region Bombycis mori in Compendium of Material Medica be refreshing worm national treasure, thinks that this insecticide has invigorating the liver and kidney, tonifying YANG, antidotal spirited effect.Scientific research shows: the male Bombycis mori body contains abundant active substance, and androgen content is abundant, and is remarkable to strengthening body immunity and sexual function effect.It contains multiple compositions such as abundant cytochrome C, vitamin B12, nicotinic acid, a ecdyson and B-ecdyson, to regulating function of human body excellent efficacies is arranged.Phosphorus element content with brain supplementing action is also very abundant, and the effect of Fructus Alpiniae Oxyphyllae is arranged.Wherein brain hormone has fabulous health-care effect to middle-aged and elderly people, takes a certain amount of brain hormone and can promote the cell growth, stimulates the hypodermal cell division, and the control specific proteins is synthetic, reaches the spirited function of slow down aging.The content of fatty acid height of male Bombycis mori, and the content of its satisfied fatty acid reaches 78.6%, and essential fatty acid accounts for 43%.Essential fatty acid is a kidney-nourishing yang-strengthening medicine, it is the precursor of the necessary usefulness of synthesized human prostaglandin, if lack necessary fatty acid in the meals, then can guarantee the precursor of synthesising prostate on this basis, avoid its compensatory to increase, further relief of symptoms, this just in time the effect on its health care of life find evidence.Male Bombycis mori contains several amino acids, vitamin and trace element, and especially calcium, zinc, chromium, cadmic content are than horn of plenty.Male Bombycis mori particularly, its body contains bioactive substances such as a large amount of androgen, juvenile hormone, brain hormone and ecdyson, is " integration of edible and medicinal herbs " good merchantable brand that integrates dietetic therapy, health preserving, health care, tonification.

Semen Plantaginis is sweet, is slightly cold.Return liver, kidney, lung, small intestine meridian.The function clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, makes eye bright, and eliminates the phlegm.Be used for the edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough." Japan hanako materia medica " carries it: the ＂ diuresis drenches puckery, tonifying YANG.Control and take off essence, vexed.The therapeutic method to keep the adverse QI flowing downwards.＂

The Fructus Rubi temperature; Sweet, sour; Return kidney, urinary bladder channel.Be used for kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.The treatment enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea." property of medicine opinion ": ＂ master man kidney-jing deficiency exhausts, woman's food son arranged.Main impotence.＂ " Japan hanako materia medica ": the ＂ settling five organs, beneficial color is supported vital essence, long hair, strong will.Treat apoplexy fever of the body and frightened.＂ " Kaibao Bencao " carries it: the ＂ tonify deficiency is continuous exhausted, the reinforcing YIN-essence Jianyang, and smoothing skin, peace and internal organs, warming middle-JIAO benefit power is treated strain wind void, and tonifying liver makes eye bright.＂ " Bencao Jingshu ": the ＂ Fructus Rubi, its main QI invigorating person says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, the vital essence abundance, then body is sent out not in vain not also from light.The respectful main tonify deficiency of reviving is continuous exhausted, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.Zhen Quan master man kidney-jing deficiency exhausts, impotence, woman's food son arranged.Big bright main settling five organs, beneficial color is supported vital essence, long hair, strong will.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence.＂ " explaining abstruseness of the canon of materia medica ": Fructus Rubi, sweet putting down into kidney played a sun and controlled flaccidity, controlling nocturnal emission with astringent drugs is taken the photograph excessive, kidney tonifying and do not have scorching partially, controlling nocturnal emission with astringent drugs and puckery undoubtedly evil, the product of gold and jade also.

Semen Sesami Nigrum contains a large amount of fat and protein, also has nutritional labelings such as saccharide, vitamin A, vitamin E, lecithin, calcium, ferrum, chromium.The multiple essential amino acid that Semen Sesami Nigrum contains can quicken the metabolic function of human body under the effect of vitamin E, vitamin B1 participates in; Ferrum of Semen Sesami Nigrum-contain and vitamin E are the important component of prevention anemia, activating brain cell, elimination blood vessel cholesterol; The fat that Semen Sesami Nigrum contains mostly is unsaturated fatty acid greatly, and the effect of life lengthening is arranged; The Chinese medicine theory is thought, the effect that Semen Sesami Nigrum has invigorating the liver and kidney, moistening five ZANG-organs, physical strength profiting, longue meat, fills out brains, can be used for treating dizzy, early whitening of beard and hair, alopecia, soreness of the waist and knees, limbs fatigue due to the Liver and kidney asthenia of essence and blood, walk with difficulty, disease such as deficient five internal organs, the dry dried and withered hairs of skin, dryness of the intestine constipation, effect aspect blacking hair and nourishing face, celebrated especially.

The Radix Astragali is based on tonify deficiency, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the energy enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

Concha Ostreae cold nature salty in the mouth is returned liver, gallbladder, kidney channel.Cure mainly tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.Be used for the palpitation with fear insomnia, vertigo and tinnitus, scrofula sucutaneous nodule, note of the ancient Chinese abdominal mass mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid.The Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.Be used for spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

The Fructus Schisandrae Chinensis temperature; Sour, sweet; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia." Bencao Jingshu " carries: Fructus Schisandrae Chinensis master QI invigorating person, and all gas of lung master, acid can be received, and is just going into the lung tonifying the lung, so QI invigorating is also.Its main cough with dyspnea person, the deficiency of vital energy then goes up heap soil or fertilizer over and around the roots and does not return unit, and sour flavor having the property of astringing is taken the photograph gas and is returned unit, and then cough with dyspnea is from removing.Impairment caused by overstrain is won thin, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence." not Lu " supports the five internal organs, and heat extraction is given birth to flesh person in the moon, the special the kidney invigorating of Fructus Schisandrae Chinensis, the tonifying five ZANG-organs of holding concurrently, kidney storing essence is smartly contained then cloudy by force, receives and take the photograph then vital qi and return unit, and the public region is warm, digesting food, steam waste matter and change precise and tiny, then smart spontaneous, smart give birth to then cloudy long, so the as above all diseases of master are also.

The present invention's treatment is suffered from a deficiency of the kidney, the preparation method of soreness of the waist and knees Chinese medicine preparation comprises:

The preparation method of honey refining pill may further comprise the steps:

Get Radix Ginseng 3000g, Semen Plantaginis 3000g, Herba Ecliptae 3000g, Radix Astragali 3000g, Radix Angelicae Sinensis 3000g, Semen Cuscutae 3000g, Herba Orobanches 3000g, Fructus Rubi 3000g, Radix Rehmanniae Preparata 3000g, Fructus Cnidii 2000g, Radix Polygoni Multiflori Preparata 3000g, Semen Sesami Nigrum 3000g, Herba Epimedii 3000g, Herba Cistanches 3000g, Concha Ostreae 3000g, male Bombycis mori 3000g, Cortex Cinnamomi 3000g, Fructus Schisandrae Chinensis 3000g, Cortex Moutan 3000g.With the medical material removal of impurity in the prescription, then medical material is put into the above Chinese liquor of 60 degree and soaked 15 days, filter filtrate for later use; Filtering residue added water boil 35 minutes, filtered filtrate for later use; Filtering residue adds water again, and heated and boiled is 40 minutes for the second time, refilters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, is controlled at 80 ℃, dries postcooling, and mixing with Mel is twisted into slice; With every 5g is ball wax seal packing.Can every day three times, each ball.

The preparation method of capsule comprises: get Radix Ginseng 2000g, Semen Plantaginis 2000g, Herba Ecliptae 2000g, Radix Astragali 2000g, Radix Angelicae Sinensis 2000g, Semen Cuscutae 2000g, Herba Orobanches 2000g, Fructus Rubi 2000g, Radix Rehmanniae Preparata 2000g, Fructus Cnidii 1500g, Radix Polygoni Multiflori Preparata 2000g, Semen Sesami Nigrum 2000g, Herba Epimedii 2000g, Herba Cistanches 2000g, Concha Ostreae 2000g, male Bombycis mori 2000g, Cortex Cinnamomi 2000g, Fructus Schisandrae Chinensis 2000g, Cortex Moutan 2000g.Add 10 times of amount ethanol, heating and refluxing extraction 3 times, each 2 hours, 3 extracting solution are merged, decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, behind the sucking filtration, the relative density of filtrate is about 1.06 (20 ℃); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, and with the deionized water or the distilled water eluting of 10 times of resin column volumes, 95% ethanol elution of 5 times of resin column volumes of reuse is collected ethanol elution, removes alcohol solvent, obtains component medicated powder earlier; Incapsulate and be made as capsule, every capsules dress 0.4g.Can be per 12 be plate packing.Every day three times during use, each two.

The preparation method of granule may further comprise the steps: get Radix Ginseng 1500g, Semen Plantaginis 1500g, Herba Ecliptae 1500g, Radix Astragali 1500g, Radix Angelicae Sinensis 1500g, Semen Cuscutae 1500g, Herba Orobanches 1500g, Fructus Rubi 1500g, Radix Rehmanniae Preparata 1500g, Fructus Cnidii 1000g, Radix Polygoni Multiflori Preparata 1500g, Semen Sesami Nigrum 1500g, Herba Epimedii 1500g, Herba Cistanches 1500g, Concha Ostreae 1500g, male Bombycis mori 1500g, Cortex Cinnamomi 1500g, Fructus Schisandrae Chinensis 1500g, Cortex Moutan 1500g.Described component is mixed by proportioning, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures and pressures, flooded 20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, heating is concentrated into pasty state, puts into baking oven, be controlled at 80 ℃, the oven dry postcooling is pulverized the back and is added the mixing of 3000g starch, granulation, drying, granulate, packing, pack finished product, every bag of 4g packing.Taking after mixing it with water with warm water during use gets final product, can one day three times, and each one bag.

The preparation method of tablet may further comprise the steps: get Radix Ginseng 1500g, Semen Plantaginis 1500g, Herba Ecliptae 1500g, Radix Astragali 1500g, Radix Angelicae Sinensis 1500g, Semen Cuscutae 1500g, Herba Orobanches 1500g, Fructus Rubi 1500g, Radix Rehmanniae Preparata 1500g, Fructus Cnidii 1000g, Radix Polygoni Multiflori Preparata 1500g, Semen Sesami Nigrum 1500g, Herba Epimedii 1500g, Herba Cistanches 1500g, Concha Ostreae 1500g, male Bombycis mori 1500g, Cortex Cinnamomi 1500g, Fructus Schisandrae Chinensis 1500g, Cortex Moutan 1500g, described component is mixed by proportioning, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures and pressures, with common the dipping 15 days of the above Chinese liquor of 60 degree, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, heating is concentrated into pasty state, add starch 3000g and be mixed into soft material, granulate, dry, granulate, tabletting, pack finished product.Can per 12 one plates packing.During use one day three times, each two.

Pharmacology's toxicity test

One, test material:

Laboratory animal: mouse NIH, body weight 25-28g, male and female half and half; Rat Wistar body weight 130-160g, male and female half and half, the feedstuff of rat, mice is provided by medical college zoopery center, Shandong.

Be subjected to the reagent thing:

1, the capsule of medicine of the present invention: embodiment preparation is used with distilled water diluting during three batch equal amount of mixture experiments.

2, positive control medicine: JINGUI SHENQI WAN is provided by Harbin No.3 Traditional Chinese Medicine Factory.

Two, test method and result:

(1) get 40 of the healthy mices of body weight 25-28g, female, male half and half, be divided into four groups respectively by sex and body weight, 20 every group.1, take medicine of the present invention for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, and 4.2g crude drug/kg/d takes the positive control drug JINGUI SHENQI WAN for the 4th group, and dosage is 8g crude drug/kg/d, logotype 15 days.

Result of the test: 1,2,3 groups of mices obviously strengthen than 4 groups of mice sexual excitation degree, and the number of copulations of 1,2,3 group of mice increases by twice than the number of copulations of 4 groups of mices average every day.

Result of the test shows that medicine of the present invention has tangible excitation to the central nervous system, thus medicine of the present invention for regulate human body function equilibrium, QI invigorating, enrich blood, slow down aging strengthens metabolism, neurolysis, sexual hypofunction all have the treatment foundation.

(2) get 40 of body weight 100-130g healthy rats, male and female half and half, measure serum total cholesterol (TC), high density lipoprotein (HDL-C) and calculate TC/HDL-C ratio, be divided into four groups then at random, every group 10,1,2,3 groups of capsules of taking embodiment of the invention preparation respectively, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, 4.2g crude drug/kg/d.Take JINGUI SHENQI WAN for the 4th group, 6g crude drug/kg/d, logotype 15 days, result of the test shows that medicine of the present invention has antidepressant, improves the effect of immunity.

The animal acute toxicity test of pharmaceutical preparation of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, and body weight 20-25g is provided by Shandong University's medical college Animal Lab..

(2) be subjected to the reagent thing: the capsule that the embodiment of the invention is prepared becomes suspension with distilled water diluting.

Two, test method and result:

The mice maximum tolerance determination: get 20 of healthy mices, male and female half and half were divided three groups within 24 hours, only irritated the each 0.6ml/ of gastrointestinal, and gross weight 1.8ml is equivalent to crude drug in whole 4.0g, i.e. 100g crude drug/kg/d is equivalent to 857 times of clinical 65 kilograms of people.After the mice administration routinely feedstuff do not see animal dead in 12 days and toxic reaction do not occur.

Long term toxicity test:

Chinese medicine preparation of the present invention to mice by 7.69,19.18 and the 43.21g crude drug/12 weeks of kg continuous use (1.0ml/100g body weight, every day 2 times) and after 3 week of drug withdrawal, the result shows: Chinese medicine preparation of the present invention does not all have obvious influence to indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, the internal organs naked eyes do not find that difference changes and the histological examination result shows, after 12 weeks of medication and 3 weeks of drug withdrawal, each internal organs of rat all do not have obvious change.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to the rat long-term prescription, also do not have the difference reaction after the drug withdrawal, application safety.

The report of drug accumulation toxicity test:

Test method: select 20 healthy mices for use, female, male each 10, dosage designs per 5 days and is first phase, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Weighed once in per 5 days, and adjusted dosage, press 0.1ml/10 part BW per os and irritate stomach.After 20 days, animal does not have death condition takes place, and off-test is tried thing after 20 days by ascending-dose, and female, buck does not all have death condition and takes place.

Irritation test:

Give the white mouse vaginal dosing with 200 times of the clinical consumption per day of this product endo-medicine, observed 5.All animals are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.White mouse vagina and damaged skin are carried out irritation test, and not seeing has irritative response and other untoward reaction.

Two, test index

(1) general situation comprises body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counting.

(3) biochemical analysis, serum albumin are quantitatively, cholesterol, blood glucose be quantitative.

(4) pathological tissue inspection: get the half animal after the experimental result and weigh, sacrificed by decapitation is got blood, separate simultaneously treat others for earnest, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do the pathological tissue inspection.

Three, result of the test: show through the rat long term toxicity test, with the heavy dose of coloclysis of medicine of the present invention six months, to growth, the weight increase of rat, brain, liver, renal function are all had no side effect.Each histoorgan, the blood circulation of rat are not found that infringement changes, and medication group and matched group be no significant difference relatively.Illustrate that medicine of the present invention has QI invigorating, drug effect such as enrich blood, avirulence.

The clinical observation on the therapeutic effect test of medicine composite for curing nephrasthenia syndrome of the present invention:

One, clinical data

Observe case and be the out-patient, meet the diagnostic criteria that Chinese medical discrimination is suffered from a deficiency of the kidney, and the strict eliminating case standard of grasping, amount to 400 examples, wherein fear cold, soreness of the waist and knees 210 examples, nephrasthenia syndrome person 80 examples, menoxenia person's 40 examples, sexual hypofunction person's 229 examples, decreased cardiac function person 70 examples.Be divided into treatment group and matched group at random, wherein 300 examples are organized in treatment, male 165 examples, women 135 examples, age 30-75 year, 49.5 years old mean age, course of disease 1-5; Matched group 100 examples, male 56 examples, women 44 examples, age 32-78 year, the mean age 50, course of disease 1-5, from distribution situations such as two groups of ages, the course of disease, the state of an illness, no significant difference, P〉0.05.

Two, test case standard

1, include the case standard in: soreness of the waist and knees, fear of cold, hyposexuality, forgetful, lassitude, insomnia, dreaminess, cardiopalmus, weak, breathe hard, dizzy, enlarged tongue is big, tongue is white, the deep pulse CHI-pulse being weak.Meet above insufficiency of kidney-YANG apologist, can include the test case in.

2, get rid of the case standard:

(1) gestation or women breast-feeding their children, allergic constitution reaches this medicine allergy sufferers.

(2) merge severe cardiac cerebrovascular, primary diseases such as Liver and kidney, psychotic.

(3) deficiency of the kidney yin patient and not medication in accordance with regulations can't judge curative effect, or data is not congruent affects the treatment or safety judgement person.

Three, observation procedure

1, medication and dosage

Treatment group: take the prepared capsule of the embodiment of the invention 1, oral administration, every day 3 times, each 2.

Matched group: take JINGUI SHENQI WAN, Harbin No.3 Traditional Chinese Medicine Factory produces, and every day three times is oral, each 1 ball.

2, treat the course of treatment

All the case medication 1 month was a course of treatment.

Four, observation index

1, safety observation

(1) just routine test of hematuria

(2) darling renal function inspection

Respectively check 1 time before and after the medication

2, health giving quality observation

Related symptoms, sign change

Five, curative effect determinate standard

With reference to " new Chinese medicine clinical research guideline ".

1. clinical recovery: the symptom of suffering from a deficiency of the kidney, sign disappear.

2. produce effects: the symptom of suffering from a deficiency of the kidney, sign are obviously improved.

3. effective: the symptom of suffering from a deficiency of the kidney, sign all take a favorable turn.

4. invalid: the symptom of suffering from a deficiency of the kidney, sign no change.

Six, observed result

1, curative effect relatively

Table 1 general curative effect relatively

Group	Recovery from illness	Produce effects	Effectively	Invalid	Total effective rate %
						The treatment group	151	104	40	5	97.2
Matched group	20	43	24	13	87

As known from Table 1, two groups of curative effects compare, and there were significant differences, P＜0.05

Cardinal symptom relatively before and after the treatment of table 2 treatment group

Project	Treatment precedent number	The routine number in treatment back	Total effective rate %
				Soreness of the waist and knees	281	14	95.1
Fear of cold	107	9	93.7
				Libido disappears	235	16	92.3
Insomnia and dreamful sleep	185	12	96.2
				Lassitude	194	11	95.8
Weak dizziness and tinnitus	165	21	85.2
				Menoxenia	34	5	90.7
Forgetful	159	14	94.8

As shown in Table 2, this medicine has good improvement effect to above-mentioned kidney symptom.

Cardinal symptom relatively before and after table 3 treatment of control group

Project	Treatment precedent number	The routine number in treatment back	Total effective rate %
				Soreness of the waist and knees	85	16	80.1
Fear of cold	38	8	81.6
				Libido disappears	45	6	85.2
Insomnia and dreamful sleep	37	7	82.4
				Lassitude	49	12	75.3
Weak dizziness and tinnitus	74	13	80.5
				Menoxenia	10	6	60
Forgetful	50	5	90

By table 3 as seen, aspect doing well,improving, the treatment group obviously is better than matched group, and there is significant difference P＜0.05.

2, observed result shows, medicine of the present invention is a treatment kidney deficiency determined curative effect, and general curative effect is better than the positive control medicine, in the clinical application process, does not find any untoward reaction, illustrates that safety of medicine of the present invention is effective, no toxicity.

Claims (10)

1, a kind of treatment is suffered from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees is characterized in that, the ratio of weight and number of various components is in the described Chinese medicine preparation: 10～30 parts of Radix Ginsengs, 10～30 parts of Semen Plantaginiss, 10～30 parts of Herba Ecliptaes, 10～30 parts of the Radixs Astragali, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Semen Cuscutae, 10～30 parts of Herba Orobanchess, 10～30 parts of Fructus Rubies, 10～30 parts in Radix Rehmanniae Preparata, 10～20 parts of Fructus Cnidiis, 10～30 parts of Radix Polygoni Multiflori Preparata, 10～30 parts of Semen Sesami Nigrums, 10～30 parts of Herba Epimedii, 10～30 parts of Herba Cistanches, 10～30 parts of Concha Ostreae, 10～30 parts of male Bombycis mori, 10～30 parts of Cortex Cinnamomis, 10～30 parts of Fructus Schisandrae Chinensis, 10～30 parts of Cortex Moutans.

2, described treatment is suffered from a deficiency of the kidney according to claim 1, the Chinese medicine preparation of soreness of the waist and knees is characterized in that, the ratio of weight and number of various components is in the described Chinese medicine preparation: 10～15 parts of Radix Ginsengs, 10～15 parts of Semen Plantaginiss, 10～15 parts of Herba Ecliptaes, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Semen Cuscutae, 10～15 parts of Herba Orobanchess, 10～20 parts of Fructus Rubies, 10～20 parts in Radix Rehmanniae Preparata, 10～15 parts of Fructus Cnidiis, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Semen Sesami Nigrums, 10～20 parts of Herba Epimedii, 10～20 parts of Herba Cistanches, 10～20 parts of Concha Ostreae, 10～20 parts of male Bombycis mori, 10～20 parts of Cortex Cinnamomis, 10～20 parts of Fructus Schisandrae Chinensis, 10～20 parts of Cortex Moutans.

3, described treatment is suffered from a deficiency of the kidney according to claim 1, the Chinese medicine preparation of soreness of the waist and knees is characterized in that, the ratio of weight and number of various components is in the described Chinese medicine preparation: 10～20 parts of Radix Ginsengs, 10～20 parts of Semen Plantaginiss, 10～20 parts of Herba Ecliptaes, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Semen Cuscutae, 10～20 parts of Herba Orobanchess, 10～15 parts of Fructus Rubies, 10～15 parts in Radix Rehmanniae Preparata, 10～15 parts of Fructus Cnidiis, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Semen Sesami Nigrums, 10～15 parts of Herba Epimedii, 10～15 parts of Herba Cistanches, 10～15 parts of Concha Ostreae, 10～15 parts of male Bombycis mori, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Fructus Schisandrae Chinensis, 10～15 parts of Cortex Moutans.

4, described treatment is suffered from a deficiency of the kidney according to claim 1, the Chinese medicine preparation of soreness of the waist and knees is characterized in that, the ratio of weight and number of various components is in the described Chinese medicine preparation: 20～30 parts of Radix Ginsengs, 20～30 parts of Semen Plantaginiss, 20～30 parts of Herba Ecliptaes, 20～30 parts of the Radixs Astragali, 20～30 parts of Radix Angelicae Sinensis, 20～30 parts of Semen Cuscutae, 20～30 parts of Herba Orobanchess, 20～30 parts of Fructus Rubies, 20～30 parts in Radix Rehmanniae Preparata, 10～20 parts of Fructus Cnidiis, 20～30 parts of Radix Polygoni Multiflori Preparata, 20～30 parts of Semen Sesami Nigrums, 20～30 parts of Herba Epimedii, 20～30 parts of Herba Cistanches, 20～30 parts of Concha Ostreae, 20～30 parts of male Bombycis mori, 20～30 parts of Cortex Cinnamomis, 20～30 parts of Fructus Schisandrae Chinensis, 20～30 parts of Cortex Moutans.

5, according to each described treatment in the claim 1～4 suffer from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees, it is characterized in that when described Chinese medicine preparation was fried in shallow oil decoction in use and taken, 1 dose of every day, decocting was obeyed at twice, per 30 days is a course of treatment.

6, according to each described treatment in the claim 1～4 suffer from a deficiency of the kidney, the Chinese medicine preparation of soreness of the waist and knees, it is characterized in that the dosage form of described Chinese medicine preparation is: honey refining pill, hydration pill, capsule, oral liquid, granule, colloid or syrup.

7, a kind of as in the claim 1～4 as described in each treatment suffer from a deficiency of the kidney, the preparation method of the Chinese medicine preparation of soreness of the waist and knees, it is characterized in that, described Chinese medicine preparation dosage form is a honey refining pill, its preparation method comprises: described component is put into the above Chinese liquor of 60 degree soaked 10～15 days, filter filtrate for later use; Filtering residue added water boil 30～40 minutes, filtered filtrate for later use; Filtering residue adds water again, and heated and boiled is 30～40 minutes for the second time, refilters; Three filtrates are combined, and heating is concentrated into pasty state, puts into baking oven, and postcooling is dried in 70 ℃～80 ℃ oven dry, and mixing with Mel is twisted into slice; With 5g is ball wax seal packing.

8, a kind of as in the claim 1～4 as described in each treatment suffer from a deficiency of the kidney, the preparation method of the Chinese medicine preparation of soreness of the waist and knees, it is characterized in that, described Chinese medicine preparation dosage form is a capsule, its preparation method comprises: described component is added 10 times of amounts of weight ethanol, heating and refluxing extraction 3 times each 2 hours, merges 3 extracting solution, decompression recycling ethanol and to be concentrated into liquor strength be 0.5g crude drug/mL, sucking filtration to the relative density of filtrate is 1.06; With aforementioned filtrate flow is the macroporous adsorptive resins of 10L through volume, use the deionized water or the distilled water eluting of 10 times of resin column volumes afterwards, 95% ethanol elution of 5 times of resin column volumes of reuse, collect ethanol elution, remove alcohol solvent, obtain component medicated powder, incapsulate and be made as capsule, every capsules dress 0.4g.

9, a kind of as in the claim 1～4 as described in each treatment suffer from a deficiency of the kidney, the preparation method of the Chinese medicine preparation of soreness of the waist and knees, it is characterized in that, described Chinese medicine preparation dosage form is a granule, its preparation method comprises: described component is mixed by proportioning, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures and pressures, flooded 10～20 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, and heating is concentrated into pasty state, put into baking oven, 80 ℃ of oven dry, the oven dry postcooling is pulverized the back and is added the starch mixing, granulate, dry, granulate, packing, every bag of 4～6g packing.

10, a kind of as in the claim 1～4 as described in each treatment suffer from a deficiency of the kidney, the preparation method of the Chinese medicine preparation of soreness of the waist and knees, it is characterized in that, described Chinese medicine preparation dosage form is a tablet, its preparation method comprises: described component is mixed by proportioning, drop into pulverizer and be ground into fine powder, after sieving, puts into fine powder the acid and alkali-resistance infusion kettle, at normal temperatures and pressures, with common the dipping 10～20 days of the above Chinese liquor of 60 degree, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, and heating is concentrated into pasty state, add starch and mix, dry, tabletting.