CN105232880A - Traditional Chinese medicine additive treating heat-toxin exuberance type hysteritis of sows and preparation method thereof - Google Patents
Traditional Chinese medicine additive treating heat-toxin exuberance type hysteritis of sows and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine additive treating heat-toxin exuberance type hysteritis of sows and a preparation method thereof. The traditional Chinese medicine additive is prepared from lycopus lucidus, scutellariae barbatae, herba leonuri, salvia chinensis, ailanthus altissima, rhizoma dioscoreae hypoglaueae, thunberg grapevine roots, astilbe chinensis, homalomena occulta, sambucus adnata, ovateleaf holly bark, achyranthes aspera, viola japonica, artemisia argyi, clematis chinensis, thistles, lotus petiole, salviae miltiorrhizae, pyrrosia porosa, elaeagnus commutate, common clubmoss herb, tea begonia, angelica sinensis and partedleaf violet herb. The additive has the advantages that the additive has the effects of promoting blood circulation to remove blood stasis, clearing away heat and toxic materials and reducing pus and swell, has the functions of cooling the blood, relieving pain and resisting infection, is mainly used for treating heat-toxin exuberance type hysteritis of the sows, and has the advantages of being low in toxic and side effect, low in cost, free of traditional Chinese medicine additive residues, capable of reducing the death rate, high in healing rate and the like.
Description
Technical field
The present invention relates to Animal Medicine technical field, particularly relate to one and treat metritic Chinese medicine additive of sow hyperactivity of toxic heat type and preparation method thereof.
Background technology
Gilt Uterus inflammation is Farrowing and puerperal, and uterus is sometimes infected and is inflamed.The cause of disease has: difficult labour, placenta retention, and the prolapsus uteri, performs the operation during practise midwifery unclean, operation is rough, causes vulneratio uteri, puerperal infection, and sterilization is not thorough during artificial insemination, have pathogenic bacterium in boar genitals or seminal fluid during natural mating, rheuminess thing etc. can cause endometritis.Sow malnutrition.Thin and weak, when resistance declines, in its reproductive tract, non-pathogenic bacteria also can cause morbidity.
Gilt Uterus inflammation can be divided into acute and chronic endometritis.1. acute endometritis: General Symptoms is obvious, sow body temperature raises, lassitude, loss of appetite or absolutely useless, often exert duty, especially when sow just keeps down, intravaginal is flowed out white slimy or is with the contaminated bronzing mucus of stink or purulent secretion, secretions sticks at root of the tail portion, stench unpleasant.Sometimes there is colic symptoms in sow.Acute metritis is multiple is born in puerperal and post-abortion.2. chronic endometritis: many treatment by acute endometritis is transformed not in time.Sick pig General Symptoms is not obvious.Sick pig periodically may discharge a small amount of muddy mucus from intravaginal.Sow is often postponed and oestrusing, or it is abnormal to oestrus, and namely enablely regularly oestruses, also Repeat breeding.
Gilt Uterus intimitis is the major issue that puzzlement large-scale pig farm is raised pigs, and in recent years, have the trend progressively spread, sickness rate about 20%, some pig farms sickness rate can up to more than 40%.Gilt Uterus intimitis is one of principal disease in pig breeding dysfunction disease, and the cause of disease is very complicated, and research both at home and abroad shows that the cause of disease of primary disease relates to multiple pathogenic microorganisms.This disease is mainly in puerperal, and the replacement gilt of part maiden also may occur, if affected pig can not get treating timely and effectively, often transfer recessiveness or chronic infection to, lactation amount minimizing, agalactia or milk are of poor quality, grudge piglet suckling, suckling pig is caused to be had loose bowels, dysplasia; Estrus cycle disorder, Repeat breeding, farrowing is few, produces the diseases such as stillborn fetus, if after developing into intractable metritis, then can increase and produce sow mortality, and easy secondary infection other diseases, and strengthen the loss on pig farm.
Traditional Chinese veterinary medicine think primary disease be owing to passing through, puerperal vessels of the uterus hollow, evil poison is invaded in taking advantage of a weak point in opponent's defence, and pyretic toxicity twines the long-pending part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, qi depression to blood stasis, and Liver Channel amasss strongly fragrant, hinders healthy energy greatly, the disease that deficiency and coldness is mingled with.Belong to leukorrheal diseases category.There is the general General Symptoms of metritic sow not obvious, just show as appetite decline or do not eat, white or faint yellow mucus (weakness of the spleen and kidney type) is flowed out from intravaginal, or flow out clear yellow viscous thing from vagina, be attached to around root of the tail, vaginal orifice, stench unpleasant (damp heat downward flowing type), or flow out as water from washing rice sample mucus from vagina, carry clot or pus secretly, band stench, affects lactogenic (hyperactivity of toxic heat type), there is not Temperature changing in most pig, also have temperature of pig body slightly to raise, after ablactation sow yet more person to oestrus postponement or non-estrus, impact is impregnated.
But at present in large-scale pig farm is produced, sow generation metritis is comparatively common, because the cause of disease of this disease is more complicated; not easily symptomatic treatment, thus, western medicine often curative effect does not show; affect suckling pig growth, oestrus of sow is postponed, and brings greater loss to production.
Summary of the invention
Technical problem to be solved by this invention is to provide one to treat metritic Chinese medicine additive of sow hyperactivity of toxic heat type and preparation method thereof, adopt this Chinese medicine additive to suffering from the metritic treatment of sow hyperactivity of toxic heat type, there is toxic and side effects low, with low cost, without Chinese medicine additive residual quantity, reduce mortality rate, cure rate advantages of higher.
In order to realize foregoing invention object, the invention provides the Chinese medicine additive promoting piglet growth, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 12-24 weight portion, Herba Scutellariae Barbatae 10-30 weight portion, Herba Leonuri 13-33 weight portion, Herba Salviae Chinensis 14-28 weight portion, Rhizoma Dioscoreae Septemlobae 12-22 weight portion, Herba Eupatorii Heterophylli 15-30 weight portion, Rhizoma Homalomenae 9-18 weight portion, Herba Sambuci Adnatae 15-25 weight portion, Radix Achyranthis 14-32 weight portion, Herba Violae japonicae 16-34 weight portion, Herba Acroptili repentis 15-25 weight portion, Radix Clematidis 15-42 weight portion, Herba Cirsii 13-32 weight portion, Petiolus nelumbinis 14-22 weight portion, Radix Salviae Miltiorrhizae 16-33 weight portion, Herba pyrrosiae mollis 13-20 weight portion, Herba Lycopodii 11-31 weight portion, Rhizoma Begoniae Fimbristipulatae 14-26 weight portion, Radix Angelicae Sinensis 13-32 weight portion and Herba Violae dissectae 15-45 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 13-24 weight portion, Herba Scutellariae Barbatae 12-30 weight portion, Herba Leonuri 14-32 weight portion, Herba Salviae Chinensis 15-25 weight portion, Rhizoma Dioscoreae Septemlobae 14-20 weight portion, Herba Eupatorii Heterophylli 15-30 weight portion, Rhizoma Homalomenae 10-18 weight portion, Herba Sambuci Adnatae 15-25 weight portion, Radix Achyranthis 15-30 weight portion, Herba Violae japonicae 17-33 weight portion, Herba Acroptili repentis 16-24 weight portion, Radix Clematidis 17-40 weight portion, Herba Cirsii 15-30 weight portion, Petiolus nelumbinis 15-20 weight portion, Radix Salviae Miltiorrhizae 18-31 weight portion, Herba pyrrosiae mollis 15-20 weight portion, Herba Lycopodii 12-30 weight portion, Rhizoma Begoniae Fimbristipulatae 15-25 weight portion, Radix Angelicae Sinensis 14-31 weight portion and Herba Violae dissectae 16-42 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 18 weight portion, Herba Scutellariae Barbatae 24 weight portion, Herba Leonuri 30 weight portion, Herba Salviae Chinensis 22 weight portion, Rhizoma Dioscoreae Septemlobae 16 weight portion, Herba Eupatorii Heterophylli 24 weight portion, Rhizoma Homalomenae 12 weight portion, Herba Sambuci Adnatae 20 weight portion, Radix Achyranthis 17 weight portion, Herba Violae japonicae 32 weight portion, Herba Acroptili repentis 19 weight portion, Radix Clematidis 34 weight portion, Herba Cirsii 28 weight portion, Petiolus nelumbinis 16 weight portion, Radix Salviae Miltiorrhizae 30 weight portion, Herba pyrrosiae mollis 17 weight portion, Herba Lycopodii 22 weight portion, Rhizoma Begoniae Fimbristipulatae 18 weight portion, Radix Angelicae Sinensis 30 weight portion and Herba Violae dissectae 36 weight portion.
Described Chinese medicine additive also comprises: Cortex Ilicis Rotundae, Cortex Ailanthi, Radix vitis thunbergii (Radix Vitis Adstrictae) and Fructus elaeagni glabrae.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 12-24 weight portion, Herba Scutellariae Barbatae 10-30 weight portion, Herba Leonuri 13-33 weight portion, Herba Salviae Chinensis 14-28 weight portion, Rhizoma Dioscoreae Septemlobae 12-22 weight portion, Herba Eupatorii Heterophylli 15-30 weight portion, Rhizoma Homalomenae 9-18 weight portion, Herba Sambuci Adnatae 15-25 weight portion, Radix Achyranthis 14-32 weight portion, Herba Violae japonicae 16-34 weight portion, Herba Acroptili repentis 15-25 weight portion, Radix Clematidis 15-42 weight portion, Herba Cirsii 13-32 weight portion, Petiolus nelumbinis 14-22 weight portion, Radix Salviae Miltiorrhizae 16-33 weight portion, Herba pyrrosiae mollis 13-20 weight portion, Herba Lycopodii 11-31 weight portion, Rhizoma Begoniae Fimbristipulatae 14-26 weight portion, Radix Angelicae Sinensis 13-32 weight portion, Herba Violae dissectae 15-45 weight portion, Cortex Ilicis Rotundae 13-25 weight portion, Cortex Ailanthi 3-5 weight portion, Radix vitis thunbergii (Radix Vitis Adstrictae) 12-22 weight portion and Fructus elaeagni glabrae 14-32 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 18 weight portion, Herba Scutellariae Barbatae 24 weight portion, Herba Leonuri 30 weight portion, Herba Salviae Chinensis 22 weight portion, Rhizoma Dioscoreae Septemlobae 16 weight portion, Herba Eupatorii Heterophylli 24 weight portion, Rhizoma Homalomenae 12 weight portion, Herba Sambuci Adnatae 20 weight portion, Radix Achyranthis 17 weight portion, Herba Violae japonicae 32 weight portion, Herba Acroptili repentis 19 weight portion, Radix Clematidis 34 weight portion, Herba Cirsii 28 weight portion, Petiolus nelumbinis 16 weight portion, Radix Salviae Miltiorrhizae 30 weight portion, Herba pyrrosiae mollis 17 weight portion, Herba Lycopodii 22 weight portion, Rhizoma Begoniae Fimbristipulatae 18 weight portion, Radix Angelicae Sinensis 30 weight portion, Herba Violae dissectae 36 weight portion, Cortex Ilicis Rotundae 24 weight portion, Cortex Ailanthi 3 weight portion, Radix vitis thunbergii (Radix Vitis Adstrictae) 14 weight portion and Fructus elaeagni glabrae 30 weight portion.
The dosage form of described Chinese medicine additive is powder, and its preparation method is:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6-12 hour, with slow fire boiling, decocting time is 3-5 hour, decoction liquor is filtered, obtains the first filtrate, the quality of the water added be the 2-4 of the powder quality that the first step obtains doubly;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2-4 hour, filters acquisition second filtrate, and the quality of the water added is 2-4 times of the powder quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered and obtains described powder.
Wherein, the dosage form of described Chinese medicine additive is granule, its preparation method is: mixed in described ratio by described raw material, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature of spray dryer 160 ~ 175 DEG C, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder and obtain described granule.
The invention has the beneficial effects as follows: the present invention has blood circulation promoting and blood stasis dispelling, effect of heat-clearing and toxic substances removing and detumescence of suppurating, have cooling blood and relieving pain and anti-infective effect concurrently, cure mainly sow hyperactivity of toxic heat type metritis, have toxic and side effects low, with low cost, without Chinese medicine additive residual quantity, reduce mortality rate and cure rate advantages of higher.
Detailed description of the invention
The invention provides one and treat the metritic Chinese medicine additive of sow hyperactivity of toxic heat type, Chinese medicine additive comprises following raw medicinal material: Herba Lycopi, Herba Scutellariae Barbatae, Herba Leonuri, Herba Salviae Chinensis, Cortex Ailanthi, Rhizoma Dioscoreae Septemlobae, Radix vitis thunbergii (Radix Vitis Adstrictae), Herba Eupatorii Heterophylli, Rhizoma Homalomenae, Herba Sambuci Adnatae, Cortex Ilicis Rotundae, Radix Achyranthis, Herba Violae japonicae, Herba Acroptili repentis, Radix Clematidis, Herba Cirsii, Petiolus nelumbinis, Radix Salviae Miltiorrhizae, Herba pyrrosiae mollis, Fructus elaeagni glabrae, Herba Lycopodii, Rhizoma Begoniae Fimbristipulatae, Radix Angelicae Sinensis and Herba Violae dissectae.
Wherein, the pharmacological property of each raw medicinal material is:
Fructus elaeagni glabrae: nature and flavor: acid is flat.Cure mainly: leaf: antiasthmatic-antitussive.Really: astringing to arrest diarrhea.Root: relieving stranguria by diuresis, dissipating blood stasis for subsidence of swelling.
Herba pyrrosiae mollis: source: " mount emei medicine is planted ".Cure mainly: control stranguria, traumatic hemorrhage.1. " mount emei medicine is planted ": " and with flour, apply and control edge of a knife wound." 2. " register planted by Guangxi medicine ": " is pleasant, diuresis."
Rhizoma Homalomenae: nature and flavor: bitter, pungent, temperature.Gui Jing: return liver, kidney channel.Cure mainly: wind-damp dispelling, muscle reinforcing and bone strengthening, promoting blood circulation and stopping pain.For anemofrigid-damp arthralgia, chills and pain of the waist and kness, lower limb contracture is numb.
Radix vitis thunbergii (Radix Vitis Adstrictae): source: " detailed outline ".Nature and flavor: 1. " detailed outline ": " sweet, flat, nontoxic." 2. " Fujian Chinese herbal medicine ": " is micro-sweet pungent, flat." cure mainly: clearing away damp-heat, detumescence poison.To harness the Yellow River subcutaneous ulcer, arthralgia chiefly caused by damp pathogen, pyretic stranguria, dysentery, toxic swelling, scrofula, traumatic injury.1. " detailed outline ": " controling the inferior burnt burning pain drenches vexed, detumescence poison." 2. " conventional glossary of Herbs and Drugs among the people ": " treats for stomachache, and treats hemorrhoid, diuresis of stimulating the menstrual flow." 3. " Guizhou side's medicine among the people collection ": " subsides a swelling, and disappear expansion.Outer for traumatic injury, control bones and muscles pain, synthetism." 4. " Fujian Chinese herbal medicine ": " the meridian dredging, wind-damp dispelling."
Cortex Ailanthi: source: " property of medicine opinion ".Nature and flavor: pained, cold.1. supplement to the Herbal: " bitter in the mouth, slightly poisonous." 2. " Amplification on Materia Medica addendum ": " is cool in nature." 3. " Bencao Congxin ": " is bitter, cold, puckery." return through: enter stomach, large intestine channel.Cure mainly: heat extraction, dampness, astringing intestine to stop diarrhea, hemostasis, parasite killing.Control chronic dysentery, chronic diarrhea, discharging fresh blood stool, metrorrhagia, leukorrhagia, seminal emission, nebulousurine, ascarid.
Herba Leonuri: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: return liver, pericardium channel.Cure mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Petiolus nelumbinis: nature and flavor: micro-hardship is flat.Gui Jing: enter liver, spleen, stomach warp.Cure mainly: clearing away summer-heat, alleviating distention in middle-JIAO is regulated the flow of vital energy.Dizzy for heatstroke, uncomfortable in chest, the stagnation of QI.
Radix Clematidis: nature and flavor: pungent, salty, temperature.Gui Jing: return urinary bladder channel.Cure mainly: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, bone is choked with sobs larynx.
Cortex Ilicis Rotundae: nature and flavor: bitter, cool.Cure mainly: heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For flu, tonsillitis, laryngopharynx swelling and pain, acute gastroenteritis, rheumatic ostalgia; Traumatic injury is controlled in external, carbuncle furuncle infections, traumatic hemorrhage, burn and scald.
Rhizoma Begoniae Fimbristipulatae: source: " register planted by Guangxi medicine ".Nature and flavor: sweet are cool.Cure mainly: clearing away heat and cooling blood, promoting blood circulation and detoxication.Control summer-heat hyperpyrexia, cough due to lung-heat, spitting of blood, osteopatia sprain, blood stasis pain, sore scabies, burn due to hot liquid or fire.
Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Herba Violae japonicae: nature and flavor: bitter, micro-pungent, cold.Cure mainly: heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.For acute conjunctivitis, pharyngolaryngitis, acute icterohepatitis, mastitis, carbuncle furuncle and phyma poison, suppurative osteomyelitis, venom.
Herba Violae dissectae: source: " Jilin Chinese herbal medicine ".Nature and flavor: " plateau Chinese herbal treatment handbook ": " bitter, cold." return through: " plateau Chinese herbal treatment handbook ": " enters the heart, spleen, kidney three warp." curing mainly: 1. " Jilin Chinese herbal medicine ": " heat-clearing and toxic substances removing, subduing inflammation.Control innominate toxic swelling, furuncle." 2. " plateau Chinese herbal treatment handbook ": " heat-clearing and toxic substances removing, repercussive eliminating stagnation.Control carbuncle skin ulcer and treat poison, stranguria with turbid discharge nephritis."
Herba Cirsii: source: " this chapter is through focusing ".Nature and flavor: sweet are cool.1. " Japan hanako materia medica ": " cool, nontoxic." 2. " book on Chinese herbal medicine converges and says ": " sweet and slightly bitter taste, gas is trembled with fear, nontoxic." return through: enter liver, spleen channel.1. " explaining abstruseness of the canon of materia medica ": " enter spleen, liver two warp." 2. " book on Chinese herbal medicine is newly organized ": " enters lung, spleen two warp." cure mainly: removing heat from blood, blood stasis dispelling, hemostasis.Control haematemesis, epistaxis, hematuria, stranguria with blood, have blood in stool, metrorrhagia, acute infectious hepatitis, wound hemorrhage, furuncle, carbuncle poison.
Rhizoma Dioscoreae Septemlobae: source: " herbal classic ".Nature and flavor: bitter are flat.1. " herbal classic ": " bitter, flat." 2. " not Lu ": " be sweet, nontoxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " slightly warm in nature, the micro-acid of taste." return through: enter liver, stomach, urinary bladder channel.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter liver, spleen, urinary bladder channel." 2. " detailed outline ": " enters bright, the JUE YIN meridian of foot sun." 3. " Thunder God concocts property of medicine solution ": " enters spleen, kidney, bladder three warp." cure mainly: dispel the wind, dampness removing.Dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain, dysuria, stranguria with turbid discharge, seminal emission, damp and hot sore.
Herba Acroptili repentis: source: " Chinese Herbal Medicine in Xinjiang handbook ".Cure mainly: " Chinese Herbal Medicine in Xinjiang handbook ": " heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Control carbuncle furuncle, innominate toxic swelling, arthritis."
Herba Scutellariae Barbatae: nature and flavor: pungent, bitter, cold.Gui Jing: return lung, liver, kidney channel.Cure mainly: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.
Herba Sambuci Adnatae: source: " Yunnan Chinese herbal medicine ".Nature and flavor: Xin Gan, temperature.1. " Yunnan Chinese herbal medicine ": " pungent, temperature." 2. " Chinese herbal medicine is commonly used in Tibet ": " is sweet light, flat." 3. " Kunming conventional medical herbs among the people ": " is sour and astringent, flat." cure mainly: dispel the wind, diuretic, dissipating blood stasis, dredging collateral.Control acute and chronic nephritis, rheumatalgia, rubella pruritus, poliomyelitis sequela, sprains, fracture.1. " Yunnan Chinese herbal medicine ": " dispelling, collateral-activating, dissipating blood stasis is antipruritic." 2. " Chinese herbal medicine is commonly used in Tibet ": " promoting blood circulation to remove blood stasis, bone and muscle strengthening, wind-damp dispelling, inducing diuresis to remove edema.Control wind alunite arthritis, chronic lambago and skelalgia, sprains, hematoma, edema." 3. " Kunming conventional medical herbs among the people ": " wind-damp dispelling, enriches blood, invigorates blood circulation, diuresis."
Herba Lycopodii: nature and flavor: micro-hardship, pungent, temperature.Gui Jing: return liver,spleen,kidney warp.Cure mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.
Herba Eupatorii Heterophylli: source: " Yunnan Chinese herbal medicine ".Nature and flavor: " Yunnan Chinese herbal medicine ": " sweetness and bitterness, tepor." curing mainly: 1. " Yunnan Chinese herbal medicine ": " blood circulation and promoting silt, removing damp and stopping pain." 2. " Kunming conventional medical herbs among the people ": " blood circulation promoting and blood stasis dispelling, regulating menstruation row water."
Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Cure mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Achyranthis: nature and flavor: micro-hardship is cool.Cure mainly: heat clearing away, removing toxic substances, diuresis.For cold, fever, tonsillitis, diphtheria, mumps, malaria, rheumatic arthritis, urinary system calculus, oedema due to nephritis.
Herba Salviae Chinensis: source: come from " detailed outline ".Nature and flavor: acrid in the mouth; Bitter; Cold nature.Gui Jing: return liver; Spleen channel.Cure mainly: blood circulation promoting and blood stasis dispelling; Clearing away heat-damp and promoting diuresis; Mass dissipating and swelling eliminating.Main menoxenia; Dysmenorrhea; Amenorrhea; Metrorrhagia, has blood in stool; Jaundice due to damp-heat; Hot toxic-heat and blood stasis; Drench pain; Leukorrhagia; Rheumatic ostalgia; Scrofula; Skin ulcer swells; Acute mastitis; Herpes zoster; Leprosy; Traumatic injury wound is swollen
Herba Lycopi: nature and flavor: bitter, pungent, tepor.Gui Jing: return liver, spleen channel.Cure mainly: blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.
Embodiment 1 Chinese medicine additive 1
Embodiments provide one and treat the metritic Chinese medicine additive of sow hyperactivity of toxic heat type, be made up of the raw medicinal material of following parts by weight: Herba Lycopi 18 weight portion, Herba Scutellariae Barbatae 24 weight portion, Herba Leonuri 30 weight portion, Herba Salviae Chinensis 22 weight portion, Rhizoma Dioscoreae Septemlobae 16 weight portion, Herba Eupatorii Heterophylli 24 weight portion, Rhizoma Homalomenae 12 weight portion, Herba Sambuci Adnatae 20 weight portion, Radix Achyranthis 17 weight portion, Herba Violae japonicae 32 weight portion, Herba Acroptili repentis 19 weight portion, Radix Clematidis 34 weight portion, Herba Cirsii 28 weight portion, Petiolus nelumbinis 16 weight portion, Radix Salviae Miltiorrhizae 30 weight portion, Herba pyrrosiae mollis 17 weight portion, Herba Lycopodii 22 weight portion, Rhizoma Begoniae Fimbristipulatae 18 weight portion, Radix Angelicae Sinensis 30 weight portion and Herba Violae dissectae 36 weight portion,
The dosage form of Chinese medicine additive is granule, its preparation method is: mixed in described ratio by described raw material, adding relative to the determining alcohol of 5 times, mixture is the ethanol of 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1.5ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.07, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 80 DEG C, is ground into powder subsequently, makes dried cream powder and obtains described granule.
Embodiment 2 Chinese medicine additive 2
Embodiments provide one and treat the metritic Chinese medicine additive of sow hyperactivity of toxic heat type, be made up of the raw medicinal material of following parts by weight: Herba Lycopi 18 weight portion, Herba Scutellariae Barbatae 24 weight portion, Herba Leonuri 30 weight portion, Herba Salviae Chinensis 22 weight portion, Rhizoma Dioscoreae Septemlobae 16 weight portion, Herba Eupatorii Heterophylli 24 weight portion, Rhizoma Homalomenae 12 weight portion, Herba Sambuci Adnatae 20 weight portion, Radix Achyranthis 17 weight portion, Herba Violae japonicae 32 weight portion, Herba Acroptili repentis 19 weight portion, Radix Clematidis 34 weight portion, Herba Cirsii 28 weight portion, Petiolus nelumbinis 16 weight portion, Radix Salviae Miltiorrhizae 30 weight portion, Herba pyrrosiae mollis 17 weight portion, Herba Lycopodii 22 weight portion, Rhizoma Begoniae Fimbristipulatae 18 weight portion, Radix Angelicae Sinensis 30 weight portion, Herba Violae dissectae 36 weight portion, Cortex Ilicis Rotundae 24 weight portion, Cortex Ailanthi 3 weight portion, Radix vitis thunbergii (Radix Vitis Adstrictae) 14 weight portion and Fructus elaeagni glabrae 30 weight portion.
The dosage form of Chinese medicine additive is powder, and its preparation method is:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 8 hours, with slow fire boiling, decocting time is 4 hours, decoction liquor is filtered, obtains the first filtrate, and the quality of the water added is 3 times of the powder quality that the first step obtains;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 4 hours, filters acquisition second filtrate, and the quality of the water added is 2 times of the powder quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered and obtains described powder.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, each 10 of hero, with the Chinese medicine additive 1 of the embodiment of the present invention 1 for object, dose design is first phase in every 7 days, each issue dosage is respectively 0.10LD50,0.20LD50,0.25LD50,0.30LD50,0.40LD50, the LD50 that is female, male mice of this sample be 4000m part/k part BW (five dosage is 500,750,1100,1800,2400m part/k part BW).Within every 7 days, weigh once, adjustment dosage, by 0.05ml/10 part BW per os gavage.After 28 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 28 days, female, buck all occurs without death condition.With the Chinese medicine additive of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
2, acute toxicity test
Application NIH mice 40, SPF level, male and female half and half, body weight 15 ~ 20g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Chinese medicine additive prepared by embodiments of the invention 1 is dissolved in water, (concentration is 6.75g crude drug/ml, maximum concentration) gavage, gavage volume is 7ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 3 times, delivery time 8 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 21 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore the acute toxicity of the Chinese medicine additive 1 of the embodiment of the present invention 1 is low, clinical drug safety.With the Chinese medicine additive of embodiment 2 for object, carry out toxicity test according to the method described above, result is as identical in embodiment 1.
Treatment contrast test:
In May ,-2012 in May, 2010,400 are had to suffer from the metritic sow of hyperactivity of toxic heat type, 231 are suffered from metritic sow and be divided into three experimental grouies at random, be respectively embodiment 1 group, embodiment 2 groups and matched group, three experimental group medications are as follows: embodiment 1 group and embodiment 2 groups use the Chinese medicine additive 1 of the embodiment of the present invention 1 respectively, the Chinese medicine additive 2 of embodiment 2 is treated; Matched group adopts Chinese medicine additive to treat, and wherein, the dose that embodiment is 1 group is every every day, is mixed into 25g Chinese medicine additive in the Chinese medicine of every kilogram; The dose that embodiment is 2 groups is every every day, 35g Chinese medicine additive is mixed in the Chinese medicine of every kilogram, the Chinese medicine additive of matched group selects Cloprostenol 0.4mg/mL, estradiol benzoate 8mg/mL carries out neck injection, every day 1 time, and the treatments period of three experimental grouies is 10-20 days; Treatment terminates rear observation three months, and record cure rate and the mortality rate of each group of sow, result is as shown in table 1.
Wherein, curative effect determinate standard is as follows:
Cure: affected pig body temperature is down to normally, appetite is normal, and spirit is good, and vaginal discharge disappears, and breast amount does not reduce, 10-15d after wean, and sow spontaneous estrus is also become pregnant;
Effective: affected pig body temperature is down to normally, and appetite takes a turn for the better, spirit is general, vaginal discharge hour, and breast amount slightly reduces, 10-15d after wean, and sow does not oestrus or oestruses and do not become pregnant;
Invalid: the affected pig state of an illness does not alleviate or aggravation, or dead.
Table 1 each experimental group therapeutic effect synopsis
| Group | Ill sow number (head) | Invalid number | Inefficiency (%) | Effective number | Obvious effective rate (%) | Cure number | Cure rate (%) |
| Embodiment 1 group | 77 | 1 | 1.3％ | 2 | 2.6％ | 74 | 96.1％ |
| Embodiment 2 groups | 77 | 0 | 0％ | 1 | 1.3％ | 76 | 98.7％ |
| Matched group | 77 | 21 | 27.3％ | 7 | 9.1％ | 49 | 63.6％ |
Data from table 1: the Chinese medicine additive of the embodiment of the present invention 1 and embodiment 2 is obviously better than matched group to the therapeutic effect suffering from metritic sow, improve cure rate, reduce mortality rate.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. the metritic Chinese medicine additive for the treatment of sow hyperactivity of toxic heat type, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 12-24 weight portion, Herba Scutellariae Barbatae 10-30 weight portion, Herba Leonuri 13-33 weight portion, Herba Salviae Chinensis 14-28 weight portion, Rhizoma Dioscoreae Septemlobae 12-22 weight portion, Herba Eupatorii Heterophylli 15-30 weight portion, Rhizoma Homalomenae 9-18 weight portion, Herba Sambuci Adnatae 15-25 weight portion, Radix Achyranthis 14-32 weight portion, Herba Violae japonicae 16-34 weight portion, Herba Acroptili repentis 15-25 weight portion, Radix Clematidis 15-42 weight portion, Herba Cirsii 13-32 weight portion, Petiolus nelumbinis 14-22 weight portion, Radix Salviae Miltiorrhizae 16-33 weight portion, Herba pyrrosiae mollis 13-20 weight portion, Herba Lycopodii 11-31 weight portion, Rhizoma Begoniae Fimbristipulatae 14-26 weight portion, Radix Angelicae Sinensis 13-32 weight portion and Herba Violae dissectae 15-45 weight portion.
2. the metritic Chinese medicine additive for the treatment of sow hyperactivity of toxic heat type according to claim 1, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 13-24 weight portion, Herba Scutellariae Barbatae 12-30 weight portion, Herba Leonuri 14-32 weight portion, Herba Salviae Chinensis 15-25 weight portion, Rhizoma Dioscoreae Septemlobae 14-20 weight portion, Herba Eupatorii Heterophylli 15-30 weight portion, Rhizoma Homalomenae 10-18 weight portion, Herba Sambuci Adnatae 15-25 weight portion, Radix Achyranthis 15-30 weight portion, Herba Violae japonicae 17-33 weight portion, Herba Acroptili repentis 16-24 weight portion, Radix Clematidis 17-40 weight portion, Herba Cirsii 15-30 weight portion, Petiolus nelumbinis 15-20 weight portion, Radix Salviae Miltiorrhizae 18-31 weight portion, Herba pyrrosiae mollis 15-20 weight portion, Herba Lycopodii 12-30 weight portion, Rhizoma Begoniae Fimbristipulatae 15-25 weight portion, Radix Angelicae Sinensis 14-31 weight portion and Herba Violae dissectae 16-42 weight portion.
3. the metritic Chinese medicine additive for the treatment of sow hyperactivity of toxic heat type according to claim 1 and 2, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 18 weight portion, Herba Scutellariae Barbatae 24 weight portion, Herba Leonuri 30 weight portion, Herba Salviae Chinensis 22 weight portion, Rhizoma Dioscoreae Septemlobae 16 weight portion, Herba Eupatorii Heterophylli 24 weight portion, Rhizoma Homalomenae 12 weight portion, Herba Sambuci Adnatae 20 weight portion, Radix Achyranthis 17 weight portion, Herba Violae japonicae 32 weight portion, Herba Acroptili repentis 19 weight portion, Radix Clematidis 34 weight portion, Herba Cirsii 28 weight portion, Petiolus nelumbinis 16 weight portion, Radix Salviae Miltiorrhizae 30 weight portion, Herba pyrrosiae mollis 17 weight portion, Herba Lycopodii 22 weight portion, Rhizoma Begoniae Fimbristipulatae 18 weight portion, Radix Angelicae Sinensis 30 weight portion and Herba Violae dissectae 36 weight portion.
4. the metritic Chinese medicine additive for the treatment of sow hyperactivity of toxic heat type according to any one of claim 1-3, it is characterized in that, described Chinese medicine additive also comprises: Cortex Ilicis Rotundae, Cortex Ailanthi, Radix vitis thunbergii (Radix Vitis Adstrictae) and Fructus elaeagni glabrae.
5. the metritic Chinese medicine additive for the treatment of sow hyperactivity of toxic heat type according to any one of claim 1-4, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 12-24 weight portion, Herba Scutellariae Barbatae 10-30 weight portion, Herba Leonuri 13-33 weight portion, Herba Salviae Chinensis 14-28 weight portion, Rhizoma Dioscoreae Septemlobae 12-22 weight portion, Herba Eupatorii Heterophylli 15-30 weight portion, Rhizoma Homalomenae 9-18 weight portion, Herba Sambuci Adnatae 15-25 weight portion, Radix Achyranthis 14-32 weight portion, Herba Violae japonicae 16-34 weight portion, Herba Acroptili repentis 15-25 weight portion, Radix Clematidis 15-42 weight portion, Herba Cirsii 13-32 weight portion, Petiolus nelumbinis 14-22 weight portion, Radix Salviae Miltiorrhizae 16-33 weight portion, Herba pyrrosiae mollis 13-20 weight portion, Herba Lycopodii 11-31 weight portion, Rhizoma Begoniae Fimbristipulatae 14-26 weight portion, Radix Angelicae Sinensis 13-32 weight portion, Herba Violae dissectae 15-45 weight portion, Cortex Ilicis Rotundae 13-25 weight portion, Cortex Ailanthi 3-5 weight portion, Radix vitis thunbergii (Radix Vitis Adstrictae) 12-22 weight portion and Fructus elaeagni glabrae 14-32 weight portion.
6. the metritic Chinese medicine additive for the treatment of sow hyperactivity of toxic heat type according to any one of claim 1-5, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: Herba Lycopi 18 weight portion, Herba Scutellariae Barbatae 24 weight portion, Herba Leonuri 30 weight portion, Herba Salviae Chinensis 22 weight portion, Rhizoma Dioscoreae Septemlobae 16 weight portion, Herba Eupatorii Heterophylli 24 weight portion, Rhizoma Homalomenae 12 weight portion, Herba Sambuci Adnatae 20 weight portion, Radix Achyranthis 17 weight portion, Herba Violae japonicae 32 weight portion, Herba Acroptili repentis 19 weight portion, Radix Clematidis 34 weight portion, Herba Cirsii 28 weight portion, Petiolus nelumbinis 16 weight portion, Radix Salviae Miltiorrhizae 30 weight portion, Herba pyrrosiae mollis 17 weight portion, Herba Lycopodii 22 weight portion, Rhizoma Begoniae Fimbristipulatae 18 weight portion, Radix Angelicae Sinensis 30 weight portion, Herba Violae dissectae 36 weight portion, Cortex Ilicis Rotundae 24 weight portion, Cortex Ailanthi 3 weight portion, Radix vitis thunbergii (Radix Vitis Adstrictae) 14 weight portion and Fructus elaeagni glabrae 30 weight portion.
7. the preparation method of the metritic Chinese medicine additive for the treatment of sow hyperactivity of toxic heat type according to any one of claim 1-6, is characterized in that, the dosage form of described Chinese medicine additive is powder, and its preparation method is:
The first step, is mixed in proportion described raw medicinal material, is ground into powder;
Second step, the first step is obtained powder and add in cold water and soak 6-12 hour, with slow fire boiling, decocting time is 3-5 hour, decoction liquor is filtered, obtains the first filtrate, the quality of the water added be the 2-4 of the powder quality that the first step obtains doubly;
3rd step, filters second step the filtering residue obtained and again adds in cold water, with slow fire boiling 2-4 hour, filters acquisition second filtrate, and the quality of the water added is 2-4 times of the powder quality that second step obtains;
4th step, the second filtrate mixing that the first filtrate obtain second step and the 3rd step obtain, concentrating under reduced pressure, except anhydrating, dry, pulverize powdered and obtains described powder.
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| CN201510804535.9A CN105232880A (en) | 2015-11-20 | 2015-11-20 | Traditional Chinese medicine additive treating heat-toxin exuberance type hysteritis of sows and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105797112A (en) * | 2016-04-28 | 2016-07-27 | 青岛海之星生物科技有限公司 | Feed additive with release effect and capable of treating sow metritis |
| CN105944049A (en) * | 2016-04-28 | 2016-09-21 | 青岛海之星生物科技有限公司 | Feed additive capable of treating sow metritis and preparation method of feed additive |
| CN106581316A (en) * | 2016-11-30 | 2017-04-26 | 唐山滦牧生物科技有限公司 | Irrigating solution for pig metritis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006967A (en) * | 2012-11-28 | 2013-04-03 | 河南科技大学 | Chinese medicinal composition for treating metritis of sow |
| CN103142747A (en) * | 2013-03-22 | 2013-06-12 | 刘荣彬 | Medicament for treating metritis of sow |
| CN103977279A (en) * | 2014-05-09 | 2014-08-13 | 山东新希望六和集团有限公司 | Traditional Chinese medicine additive for treating sow hysteritis and preparation method thereof |
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2015
- 2015-11-20 CN CN201510804535.9A patent/CN105232880A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006967A (en) * | 2012-11-28 | 2013-04-03 | 河南科技大学 | Chinese medicinal composition for treating metritis of sow |
| CN103142747A (en) * | 2013-03-22 | 2013-06-12 | 刘荣彬 | Medicament for treating metritis of sow |
| CN103977279A (en) * | 2014-05-09 | 2014-08-13 | 山东新希望六和集团有限公司 | Traditional Chinese medicine additive for treating sow hysteritis and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105797112A (en) * | 2016-04-28 | 2016-07-27 | 青岛海之星生物科技有限公司 | Feed additive with release effect and capable of treating sow metritis |
| CN105944049A (en) * | 2016-04-28 | 2016-09-21 | 青岛海之星生物科技有限公司 | Feed additive capable of treating sow metritis and preparation method of feed additive |
| CN106581316A (en) * | 2016-11-30 | 2017-04-26 | 唐山滦牧生物科技有限公司 | Irrigating solution for pig metritis |
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