CN104940567A - Chinese material medicine preparation for treating mild hemopoietic acute radiation sickness and preparation method thereof - Google Patents
Chinese material medicine preparation for treating mild hemopoietic acute radiation sickness and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese material medicine preparation for treating mild hemopoietic acute radiation sickness and belongs to the invention field of traditional Chinese medicines. The Chinese material medicine preparation is prepared by raw materials including angelica sinensis, ligusticum wallichii, white paeony roots, dried rehamnnia roots, prepared rehmannia roots, radix astragali, rumex japonicas roots, thinleaf adina fruits, Chinese arborvitae twig, rhodiola rosea, yetbadetajo herb, walnut kernels, spreading hedyotis herb, Chinese mahonia, epimedium, common curculigo rhizome, ginseng, male silkworm moth, cordyceps sinensis, fried white atractylodes rhizome, poria cocos, kudzu vine roots, the fruits of Chinese magnoliavine, asparagus fern and licorice roots. According to different characteristics of all Chinese material medicines, the raw materials are cleaned, sliced and preprocessed, proportional preparation is performed to prepare the Chinese material medicine preparation having the effects of replenishing blood, invigorating the circulation of blood, nourishing yin, generating body fluid, nourishing liver and kidney and replenishing essence and marrow by adopting a special method. The Chinese material medicine preparation is unique in combining and manufacturing method. Clinical verification shows that the Chinese material medicine preparation is remarkable in treatment effect, short in treatment period, low in price and free of adverse reaction and any toxic and side effects and has wide market application prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of Chinese medicine preparation for slight bone marrow form acute radialion sickness, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Slight bone marrow form acute radialion sickness, refer to human bone marrow once or short time (a few days) interior gradation be subject to the systemic disease that heavy dose of ionization radiation irradiation causes.With hemopoietic organ---the damage of bone marrow is the acute radiation sickness of its principal pathogenetic reason, and feature is that disease has stage, and clinical manifestation is mainly the diseases such as hematopoietic disorder, hemorrhage and infection.Someone is referred to as " hemopoietic type acute radiation sickness " or " BM form syndrome ".Radiation dose rate has a certain impact to radiation sickness, and in general, within the scope of doses rate, the order of severity of radiation sickness increases the weight of with the increase of close rate.The main pathological change of BM form radiation sickness is hemopoietic tissue damage, causes infection, a series of pathological changes such as hemorrhage thus.In addition, the radiation sensitive tissue such as lymphoid tissue, digestive tract and gonad is also subject to damage in various degree.After irradiating, myeloid element produces the changes such as degeneration, necrosis, residual, hollow and regeneration.Hematopoietic stem cell number declines rapidly.Blood circulation generation obstacle, bone marrow sious expansion and disintegrate, there is the phenomenons such as karyopycnosis, swelling, cracked and dissolving in inmature hematopoietic cell.The earliest, there is the destruction of grain system and Megakaryocyte in erythroneocytosis change later.Cell division is suppressed.When pathological changes further develops, occur bone marrow edema and hemorrhage, number of nucleated cells reduces so that become hollow, and medullary cavity is the filling of significant quantities of fat cell institute, there is a large amount of skein cell and plasma cell simultaneously.Due to hematopoietic disorder, skin and mucosal barrier destroy, peripheral blood neutrophil number reduces, phagocytic function weakens and is obstructed with antibody tormation, body anti-infection ability obviously declines, and crisis infects often.The feature infected posts the non-pathogenic bacteria grown in regular to invade other organ and become pathogenic bacterium, amount reproduction, causes local and systemic infection.The Therapeutic Principle of bone marrow form acute radialion sickness is each phase feature for the course of disease, Comprehensive Treatment of suiting the medicine to the illness.Initial stage should use the antiradiation drug that can improve hemopoietic damage as early as possible, detoxifies, the medicine such as calm and emesis.Prevention infection and hemorrhage, hemopoietic function protecting is wanted during latent phase.Mainly infection during crisis, hemorrhage, alleviates the damage of hemopoietic function, maintains water-electrolyte balance.Convalescent period should promote the reparation of hemopoietic function, accelerates the recovery of body.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for slight bone marrow form acute radialion sickness, it is remarkable that this Chinese medicine preparation has therapeutic effect for the slight bone marrow form acute radialion sickness for the treatment of, healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of slight bone marrow form acute radialion sickness repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor: sweet, acrid, warm.Return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Record in " Japan hanako materia medica ": control a wind cutting, all blood, mend all labor, broken stagnant blood, supports fresh blood and main Disorder addiction.
Rhizoma Chuanxiong: be samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort.(or Ligusticum wallichii Franch.) dry rhizome.Nature and flavor: pungent, temperature.Return liver, gallbladder, pericardium channel.Effect: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Record in " Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjusts many arteries and veins, and broken Disorder ties stagnated blood, supports fresh blood, puts on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, and scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood.
The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: bitter, sour, are slightly cold.Return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.
Radix Rehmanniae: be the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, yin nourishing, promotes the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.
Radix Rehmanniae Preparata: be the Preparation process product of Radix Rehmanniae.Nature and flavor: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.Record in " pearl sac ": enrich blood greatly empty not enough, promoting blood circulation, physical strength profiting.
The Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Nature and flavor: sweet, temperature.Return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Rumicis Crispi: be Rumex gmelini Turcz curled dock Rumex crispus L or Radix Rumicis Japonici R. japonicus Houtt., be used as medicine with root.Nature and flavor: bitter, sour, cold.Slightly poisonous.Effect: heat-clearing and toxic substances removing, hemostasis, relieving constipation, parasite killing.For epistaxis, dysfunctional uterine hemorrhage, thrombocytopenic purpura, chronic hepatitis, perianal is scorching, constipation; External hemorrhoid is controlled in external, acute mastitis, impetigo, furuncle and phyma, tinea.Record in " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control all pyretic toxicity, rush down six internal organs excess-fire, rush down the six channels exopathogenic heat, move back chronic consumptive disease fever, diuresis, controls pyretic stranguria.Parasite killing, puts tinea skin ulcer, impetigo on the skin.
Fructus Adinae: be Rubiaceae avens Fructus Adinae Adina rubella Hance, with root, peel of stem, leaf, flower and fruit medicine.Nature and flavor: bitter, puckery, cool.Effect: heat-clearing and toxic substances removing, eliminating stasis to stop pain.Root: cold, fever, parotitis, laryngopharynx swelling and pain, rheumatalgia.Flower, really: bacillary dysentery, acute gastroenteritis, trichomonal vaginitis.Leaf, peel of stem: traumatic injury, fracture, furuncle and phyma, wound hemorrhage, skin eczema.
Cacumen Platycladi: be the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi Platycladus orientalis (L.) Franco.Nature and flavor: bitter, puckery, cold.Return lung, liver, spleen channel.Effect: cooling blood for hemostasis, growing and blacking hair.For hematemesis and epistaxis, spitting of blood, has blood in stool, metrostaxis, heat in blood alopecia, early whitening of beard and hair." book on Chinese herbal medicine just " is in record: the kind removing heat from blood that purifies the blood, remuval of damp and hot arthralgia chiefly caused by damp pathogen, arthralgia.Mash and can apply erysipelas, loose mumps swells and ache pyretic toxicity.
Radix Rhodiolae: be Crassulaceae Rhodida plant Radix Rhodiolae Rhodiola saera (Prain) Fu, with all herbal medicine.9 ~ October gathers, and cleans and dries.Nature and flavor: sweet, puckery, cold.Return lung meridian.Effect: clearing away lung-heat to relieve cough, hemostasis, leukorrhagia stopping.For cough due to lung-heat, spitting of blood, leucorrhea; Traumatic injury is controlled in external, burn and scald.
Herba Ecliptae: be the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L..Nature and flavor: sweet, sour, cold.Return kidney, Liver Channel.Effect: nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.Record in " Japan hanako materia medica ": evacuation of pus, hemostasis, logical small intestinal, applies all skin ulcers and silkworm Guo.
Semen Juglandis: the kernel chosen for the wild core of juglandaceae plant.Nature and flavor: sweet; Warm in nature.Return lung; Kidney; Large intestine channel.Effect: moistening the lung and resolving phlegm; Warming the kidney to activate YANG; Skin moistening; Relieving constipation.Main cough caused by dryness is without expectorant; Dyspnea due to deficiency; Soreness of the waist and knees; Dryness of the intestine constipation; Chapped skin.
Herba Hedyotidis Diffusae: be the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.].Nature and flavor: sweet, light, cool.Be included into stomach, large intestine, small intestine meridian.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.Record in " Quanzhou book on Chinese herbal medicine ": heat clearing away dissipating blood stasis, eliminating carbuncle detoxifies.Control ulcer sores, scrofula.Again can lung heat clearing fire, eliminating the pathogens from the lung heat.Control lung-heat dyspnea with rapid and short breath, cough against uncomfortable in chest.
Mahonia fortunei (Lindl.) Fedde: be Berberidaceae Mahonia plant Mahonia bealei (Fort.) Carr. Mahonia bealei (Fort.) Carr. and Mahonia fortunei M.fortunei (Lindl) Fedde.Be used as medicine with root, stem, leaf.Nature and flavor: bitter, cold.Effect: leaf: nourishing YIN and clearing away heat.Cure mainly pulmonary tuberculosis, flu.Root, stem: heat-clearing and toxic substances removing.Cure mainly bacillary dysentery, acute smooth gastritis, infectious hepatitis, pneumonia, pulmonary tuberculosis, bronchitis, laryngopharynx swelling and pain.Eye conjunctivitis is controlled in external, carbuncle furuncle and phyma poison, burn.
Herba Epimedii: be the dry aerial parts of Berberidaceae plant Herba Epimedii Epimedium brevicornum Maxim., Epimedium sagittatum Epimedium sagittatum (Sieb.et Zucc.) Maxim., E. Pubescens Epimedium pubescens Maxim., Epimedium wushanense Epimedium wushanense T.S.Ying or Herba Epimedii Epimedium koreanum Nakai.Nature and flavor: acrid, sweet, warm.Return liver, kidney channel.Effect: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension." not Lu ": " hard muscles and bones.Disappear scrofula, red carbuncle; Skin ulcer is arranged at bottom, washes, and goes out worm.
Rhizoma Curculiginis: be the dry rhizome of amrallid Rhizoma Curculiginis Curculigo orchioides Gaertn..Nature and flavor: pungent, heat; Poisonous.Return kidney,liver,spleen warp.Effect: kidney-replenishing, bone and muscle strengthening, dispelling cold and dampness.For sexual impotence cold sperm, muscles and bones flaccidity is soft, the cold numbness of waist knee joint, yang deficiency cold diarrhea.Record in " Japan hanako materia medica ": control all pathogenic wind, mend five kinds of strain and seven kinds of impairment, the appetizing therapeutic method to keep the adverse QI flowing downwards.
Radix Ginseng: be the dry root of Araliaceae Radix Ginseng Panax ginseng C. A. Mey..Nature and flavor: sweet, micro-hardship are flat.Gui Jing: return spleen, lung, heart channel.Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.Record in " herbal classic ": main tonifying five ZANG-organs, peace spirit, spasmolytic is throbbed with fear, except pathogen, and improving eyesight, happy Fructus Alpiniae Oxyphyllae.
Male Bombycis mori: be the male Scorpio of Bombycidae insecticide bombyx mori.Nature and flavor: salty, temperature.Return liver, kidney channel.Effect: the liver and the kidney tonifying, tonifying YANG arresting seminal emission.Control sexual impotence, seminal emission, nebulousurine, hematuria, wound, ulcer and scald.Record in " Japan hanako materia medica ": tonifying YANG thing, stopping leak essence, hematuria, warm water is hidden.Control storm wind, incised wound, chilblain, sore due to scald and burn, and skin ulcer scar of going out.
Cordyceps: for section ergot fungus cordyceps sinensis bacterium Cordyceps sinensis (Berk.) Sacc. colonizes in Stroma on Hepialidae insect larvae and larva cadaveric complex.Nature and flavor: sweet are flat.Return lung, kidney channel.Effect: invigorating the lung and the kidney, hemostasis and phlegm.For chronic cough dyspnea due to deficiency, chronic cough is spat blood, impotence and seminal emission, soreness of waist and knee joint.Record in " property of medicine is examined ": secret lean gas, specially mend the gate of vitality.
Rhizoma Atractylodis Macrocephalae (parched): be the processed product of the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Nature and flavor: bitter, sweet, temperature.Return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Record in " herbal classic ": " convulsion, subcutaneous ulcer, hidroschesis, heat extraction helps digestion for main anemofrigid-damp arthralgia, dead flesh.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor: sweet, light are flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Record in " property of medicine opinion ": appetizing, preventing or arresting vomiting is inverse, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.
Radix Puerariae: be the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi or Radix Puerariae rattan Pueraria thomsonii Benth..Nature and flavor: sweet, pungent, cool.Return spleen, stomach warp.Effect: thirsty, quenches one's thirst, measles without adequate eruption, and hematodiarrhoea, has loose bowels; Hypertension neck pain.Record in " herbal classic ": master quenches one's thirst, and body is too warm, vomiting, all numbness, play cloudy gas, separate all poison.
Fructus Schisandrae Chinensis: be the dry mature fruit of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or schisandra chinensis Schisandra sphenanthera Rehd. et Wils..Nature and flavor: sour, sweet, temperature.Return lung, the heart, kidney channel.Effect: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Radix Asparagi: be the dried root of liliaceous plant Radix Asparagi Asparagus cochinchinensis (Lour.) Merr..Nature and flavor: sweet, bitter, cold.Return lung, kidney channel.Function cures mainly: nourishing YIN to relieve dryness, and lung heat clearing is promoted the production of body fluid.For dryness of the lung dry cough, pertussis expectorant sticks, dry throat and mouth, dryness of the intestine constipation.
Radix Glycyrrhizae: be the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Nature and flavor: sweet are flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Record in " illustrated handbook planted by middle traditional Chinese medicines ": control peptic ulcer and jaundice.
Side's solution of the present invention is: Chinese angelica blood supplementing is invigorated blood circulation, Rhizoma Chuanxiong blood-activating and qi-promoting, Radix Paeoniae Alba nourishing blood for regulating menstruation, Radix Rehmanniae YIN nourishing and the production of body fluid promoting, Cacumen Platycladi removing heat from blood black hair, and above five kinds of Chinese medicine, as monarch drug in side, all returns Liver Channel, and having enriches blood invigorates blood circulation, the effect of YIN nourishing and the production of body fluid promoting.Chinese medicine is thought, primary disease main symptom is mainly " pyretic toxicity crosses Sheng " because of the cause of disease of radiation damage, and pathogenesis is that pyretic toxicity pents up cloudy point, and spleen kidney good fortune is too late, and QI and blood is impaired and cause primary disease.Invigorate blood circulation so enrich blood, YIN nourishing and the production of body fluid promoting is the basis for the treatment of slight bone marrow form acute radialion sickness, above five kinds of Chinese medicine is monarch drug, first fundamentally enrich blood invigorate blood circulation, YIN nourishing and the production of body fluid promoting, make disease obtain basic control.Radix Rehmanniae Preparata nourishing YIN and supplementing blood, beneficial essence fill out marrow, Herba Ecliptae nourishing the liver and kidney, cooling blood for hemostasis, Semen Juglandis warming the kidney to activate YANG, Rhizoma Curculiginis, Herba Epimedii kidney-replenishing, bone and muscle strengthening, Radix Ginseng invigorating primordial QI, Fu Mai promote the production of body fluid, male Bombycis mori the liver and the kidney tonifying, Cordyceps invigorating the lung and the kidney, Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid, ministerial drug in the above nine taste medicine sides of being, returns kidney channel.Kidney controlling essence storage, the raw marrow of main bone.Congenital, Liver and kidney the common origin is in essential substance for reproduction; In the day after tomorrow, supplementing nutrition of the essence that the first day after tomorrow that Liver and kidney is hidden by kidney is jointly comprehensive.On the one hand auxiliary monarch drug enrich blood invigorate blood circulation, effect of YIN nourishing and the production of body fluid promoting; On the other hand as effect that ministerial drug has nourishing the liver and kidney, beneficial essence fills out marrow.Radix Astragali invigorating QI to consolidate the body surface resistance, diuresis poison holding, Fructus Adinae, Radix Rumicis Crispi heat-clearing and toxic substances removing, Radix Rhodiolae lung heat clearing is stopped blooding, Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, inducing diuresis to remove edema, Mahonia fortunei (Lindl.) Fedde nourishing YIN and clearing away heat, Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, Radix Puerariae plays gas removing toxic substances, Radix Asparagi nourishing YIN to relieve dryness, lung heat clearing are promoted the production of body fluid, and above ten taste medicines return spleen, stomach warp, and The spleen has the function to transport and transform nutrients, stomach receiving food and drink, behaviour bromhidrosis red root originally, is source of generating QI and blood.As adjuvant drug, cause the inducement of slight bone marrow form acute radialion sickness from pathology treatment, can promote that enriching blood of the monarch and his subjects two medicine is invigorated blood circulation, effect of YIN nourishing and the production of body fluid promoting as adjuvant drug, again can using corrigent the monarch and his subjects two medicine promotes body nourishing the liver and kidney, beneficial essence fills out marrow effect.There is effect of heat-clearing and toxic substances removing simultaneously.Radix Glycyrrhizae makes medicine as in side, and have the effect of coordinating the actions of various ingredients in a prescription, mediation flavour of a drug, all medicines of this side share, the monarch and his subjects pull together, assistant makes auxiliary altogether, and effect that having enriches blood invigorates blood circulation, YIN nourishing and the production of body fluid promoting, nourishing the liver and kidney, beneficial essence fill out the effect of marrow, can effectively treat slight bone marrow form acute radialion sickness.
Another important feature of the present invention is that this Chinese medicine preparation contains abundant nutritional labeling, be rich in aminoacid and have more than 17 kinds, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylalanine, trace element containing needed by human has ferrum, chromium, copper, boron, manganese, strontium and zinc, several human body macroelement of another calcic, potassium, magnesium, phosphorus.Above nutritional labeling is all needed by human material, effectively can strengthen body immunity.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Angelicae Sinensis 16-20 part, Rhizoma Chuanxiong 13-17 part, Radix Paeoniae Alba 13-17 part, Radix Rehmanniae 18-22 part, Radix Rehmanniae Preparata 18-22 part, Radix Astragali 28-32 part, Radix Rumicis Crispi 13-17 part, Fructus Adinae 13-17 part, Cacumen Platycladi 10-14 part, Radix Rhodiolae 16-20 part, Herba Ecliptae 18-22 part, Semen Juglandis 13-17 part, Herba Hedyotidis Diffusae 22-26 part, Mahonia fortunei (Lindl.) Fedde 10-14 part, Herba Epimedii 16-20 part, Rhizoma Curculiginis 13-17 part, Radix Ginseng 10-14 part, male Bombycis mori 7-11 part, Cordyceps 4-8 part, Rhizoma Atractylodis Macrocephalae (parched) 22-26 part, Poria 13-17 part, Radix Puerariae 13-17 part, Fructus Schisandrae Chinensis 10-14 part, Radix Asparagi 10-14 part, Radix Glycyrrhizae 7-11 part.
Wherein be preferably: Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 15 parts, Radix Rehmanniae 20 parts, Radix Rehmanniae Preparata 20 parts, the Radix Astragali 30 parts, Radix Rumicis Crispi 15 parts, Fructus Adinae 15 parts, Cacumen Platycladi 12 parts, Radix Rhodiolae 18 parts, Herba Ecliptae 20 parts, Semen Juglandis 15 parts, Herba Hedyotidis Diffusae 24 parts, Mahonia fortunei (Lindl.) Fedde 12 parts, Herba Epimedii 18 parts, Rhizoma Curculiginis 15 parts, Radix Ginseng 12 parts, male Bombycis mori 9 parts, Cordyceps 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Radix Puerariae 15 parts, Fructus Schisandrae Chinensis 12 parts, Radix Asparagi 12 parts, Radix Glycyrrhizae 9 parts.
A kind of preparation method of the Chinese medicine preparation for slight bone marrow form acute radialion sickness is as follows:
Step one: by weight of the present invention, gets yellow maturity ground, Rhizoma Atractylodis Macrocephalae (parched), pulverizes, cross 200 mesh sieves, for subsequent use;
Step 2: by weight of the present invention, get Cordyceps, container put into by Radix Ginseng, adds the water of 3 times of volumes, and intense fire infusion is after 40-50 minute, and lard speech with literary allusions fiery infusion 10-20 minute, filter liquor, three times repeatedly, and merging filtrate is for subsequent use;
Step 3: by weight proportion of the present invention, get the Radix Paeoniae Alba, Radix Rehmanniae, the Radix Astragali, Radix Rumicis Crispi, Herba Epimedii, Rhizoma Curculiginis, male Bombycis mori, Poria, Radix Puerariae, Radix Asparagi medical material be placed in marmite, add the water of 8 times of volumes, intense fire infusion is after 20-30 minute, add Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Adinae, Cacumen Platycladi, Radix Rhodiolae, Herba Ecliptae, Herba Hedyotidis Diffusae, Mahonia fortunei (Lindl.) Fedde, Radix Glycyrrhizae and respectively with Fructus Schisandrae Chinensis, Semen Juglandis that bundle ties, intense fire infusion 10-20 minute, fiery infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use;
Step 4: by step 2, three gained filtrates and the mixing of step one gained powder, stir evenly, both the decoction of the slight bone marrow form acute radialion sickness for the treatment of of the present invention.
Using method of the present invention: get decoction, takes in one hour after meal, every day three times.
Medicine of the present invention have enrich blood invigorate blood circulation, effect that YIN nourishing and the production of body fluid promoting, nourishing the liver and kidney, beneficial essence fill out marrow, and good analgesic effect, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced the injury of Western medicine to patient body, alleviate the slight illness of patient, according to clinical 60 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 83.3%, two the total effective rate course for the treatment of 93.4%.
Detailed description of the invention
Embodiment one: Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 15 parts, Radix Rehmanniae 20 parts, Radix Rehmanniae Preparata 20 parts, the Radix Astragali 30 parts, Radix Rumicis Crispi 15 parts, Fructus Adinae 15 parts, Cacumen Platycladi 12 parts, Radix Rhodiolae 18 parts, Herba Ecliptae 20 parts, Semen Juglandis 15 parts, Herba Hedyotidis Diffusae 24 parts, Mahonia fortunei (Lindl.) Fedde 12 parts, Herba Epimedii 18 parts, Rhizoma Curculiginis 15 parts, Radix Ginseng 12 parts, male Bombycis mori 9 parts, Cordyceps 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Radix Puerariae 15 parts, Fructus Schisandrae Chinensis 12 parts, Radix Asparagi 12 parts, Radix Glycyrrhizae 9 parts.
Embodiment two: Radix Angelicae Sinensis 19 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 14 parts, Radix Rehmanniae 21 parts, Radix Rehmanniae Preparata 21 parts, the Radix Astragali 31 parts, Radix Rumicis Crispi 16 parts, Fructus Adinae 15 parts, Cacumen Platycladi 12 parts, Radix Rhodiolae 19 parts, Herba Ecliptae 21 parts, Semen Juglandis 15 parts, Herba Hedyotidis Diffusae 25 parts, Mahonia fortunei (Lindl.) Fedde 12 parts, Herba Epimedii 19 parts, Rhizoma Curculiginis 16 parts, Radix Ginseng 12 parts, male Bombycis mori 9 parts, Cordyceps 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 23 parts, 15 parts, Poria, Radix Puerariae 14 parts, Fructus Schisandrae Chinensis 14 parts, Radix Asparagi 11 parts, Radix Glycyrrhizae 9 parts.
Embodiment three: Radix Angelicae Sinensis 17 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 16 parts, Radix Rehmanniae 21 parts, Radix Rehmanniae Preparata 20 parts, the Radix Astragali 31 parts, Radix Rumicis Crispi 16 parts, Fructus Adinae 15 parts, Cacumen Platycladi 11 parts, Radix Rhodiolae 18 parts, Herba Ecliptae 20 parts, Semen Juglandis 16 parts, Herba Hedyotidis Diffusae 24 parts, Mahonia fortunei (Lindl.) Fedde 12 parts, Herba Epimedii 19 parts, Rhizoma Curculiginis 15 parts, Radix Ginseng 12 parts, male Bombycis mori 9 parts, Cordyceps 7 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 16 parts, Poria, Radix Puerariae 16 parts, Fructus Schisandrae Chinensis 11 parts, Radix Asparagi 11 parts, Radix Glycyrrhizae 9 parts.
Here is the clinical statistics data that patient uses medicine of the present invention:
One, physical data
Accept out-patient 60 example for medical treatment, patient is divided at random observation group and each 120 examples of matched group, wherein male 40 example, women 20 example, M-F 2:1, max age 66 years old, minimal ages 18 years old, course of disease a few days to a few weeks are not etc.Every basic documents such as two groups of patient ages, sex, courses of disease are substantially identical, no significant difference (P > 0.05).
Two, diagnostic criteria
1, had once or short time (a few days) interior gradation accept be greater than 1GY evenly or more uniform total irradiation.
2, have the symptoms such as weak, uncomfortable, loss of appetite, then lymphocyte absolute quantity minimum is 1.2*109/L.
Three, Therapeutic Method:
1, observation group is according to Medications Example one of the present invention, and weighting raw materials, by the treatment of invention implementation method, is got decoction, taken in one hour after meal, every day three times.It within 7 days, is a course for the treatment of.
2, matched group adopts the treatment of conventional western medicine zymosan, within 7 days, is a course for the treatment of.
Four, efficacy assessment standard:
1, cure: transference cure, hemogram recovers normal, and body weight increases to some extent.2, take a turn for the better: symptom disappears substantially, and hemogram is at NLL, and Individual testwas room index such as chromosome, amynologic index do not reach normal.
3, invalid: above-mentioned experimental check is all not improved or instead adds severe one.
Five, therapeutic outcome statistics:
Matched group result is added up
Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of
Wherein: total effective rate=cure rate+improvement rate
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness on the slight bone marrow form acute radialion sickness for the treatment of, effectively can improve the cure rate for the treatment of, Be very effective, cheap, have no adverse reaction and any toxic and side effects, there is wide market application foreground.
Model case and curative effect:
Case one, patient Wang, man, 36 years old, people from Qingdao City, came here and goes to a doctor on January 20th, 2010.In hospital's radiation therapy checks, because instrument and equipment fault causes radiation leaks, there is the reaction such as Nausea and vomiting, inappetence in initial symptoms, and examination in hospital lymphocyte absolute quantity minimum is 1.2*109/L.Be diagnosed as slight bone marrow form acute radialion sickness.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after two courses for the treatment of of treatment, effect is very good, and hemopoietic function of bone marrow recovers completely or substantially, and clinical symptoms all disappears.
Case two, patient Lee, female, 42 years old, people from Linyi, Shandong.On May 14th, 2010 comes here and goes to a doctor, the pretreatment before once doing hematopoietic stem cell transplantation to patient, because of accident once heavy dose of radionuclide leakage, causes body in a short time and causes acute external exposure radiation sickness with higher exposure dose.There is Nausea and vomiting in the initial stage, checks that lymphocyte absolute quantity minimum is 1.2*109/L.Be diagnosed as slight bone marrow form acute radialion sickness.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after two courses for the treatment of of treatment, effect is very good, and hemopoietic function of bone marrow recovers completely, and clinical symptoms all disappears.
Claims (4)
1. the Chinese medicine preparation for slight bone marrow form acute radialion sickness, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Radix Angelicae Sinensis 16-20 part, Rhizoma Chuanxiong 13-17 part, Radix Paeoniae Alba 13-17 part, Radix Rehmanniae 18-22 part, Radix Rehmanniae Preparata 18-22 part, Radix Astragali 28-32 part, Radix Rumicis Crispi 13-17 part, Fructus Adinae 13-17 part, Cacumen Platycladi 10-14 part, Radix Rhodiolae 16-20 part, Herba Ecliptae 18-22 part, Semen Juglandis 13-17 part, Herba Hedyotidis Diffusae 22-26 part, Mahonia fortunei (Lindl.) Fedde 10-14 part, Herba Epimedii 16-20 part, Rhizoma Curculiginis 13-17 part, Radix Ginseng 10-14 part, male Bombycis mori 7-11 part, Cordyceps 4-8 part, Rhizoma Atractylodis Macrocephalae (parched) 22-26 part, Poria 13-17 part, Radix Puerariae 13-17 part, Fructus Schisandrae Chinensis 10-14 part, Radix Asparagi 10-14 part, Radix Glycyrrhizae 7-11 part.
2. the Chinese medicine preparation for slight bone marrow form acute radialion sickness according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Radix Angelicae Sinensis 18 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 15 parts, Radix Rehmanniae 20 parts, Radix Rehmanniae Preparata 20 parts, the Radix Astragali 30 parts, Radix Rumicis Crispi 15 parts, Fructus Adinae 15 parts, Cacumen Platycladi 12 parts, Radix Rhodiolae 18 parts, Herba Ecliptae 20 parts, Semen Juglandis 15 parts, Herba Hedyotidis Diffusae 24 parts, Mahonia fortunei (Lindl.) Fedde 12 parts, Herba Epimedii 18 parts, Rhizoma Curculiginis 15 parts, Radix Ginseng 12 parts, male Bombycis mori 9 parts, Cordyceps 6 parts, Rhizoma Atractylodis Macrocephalae (parched) 24 parts, 15 parts, Poria, Radix Puerariae 15 parts, Fructus Schisandrae Chinensis 12 parts, Radix Asparagi 12 parts, Radix Glycyrrhizae 9 parts.
3. the Chinese medicine preparation for slight bone marrow form acute radialion sickness according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is decoction.
4. for a preparation method for the Chinese medicine preparation of slight bone marrow form acute radialion sickness, it is characterized in that, preparation method is as follows: step one: by weight of the present invention, gets yellow maturity ground, Rhizoma Atractylodis Macrocephalae (parched), pulverizes, cross 200 mesh sieves, for subsequent use; Step 2: by weight of the present invention, get Cordyceps, container put into by Radix Ginseng, adds the water of 3 times of volumes, and intense fire infusion is after 40-50 minute, and lard speech with literary allusions fiery infusion 10-20 minute, filter liquor, three times repeatedly, and merging filtrate is for subsequent use; Step 3: by weight proportion of the present invention, get the Radix Paeoniae Alba, Radix Rehmanniae, the Radix Astragali, Radix Rumicis Crispi, Herba Epimedii, Rhizoma Curculiginis, male Bombycis mori, Poria, Radix Puerariae, Radix Asparagi medical material be placed in marmite, add the water of 8 times of volumes, intense fire infusion is after 20-30 minute, add Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Adinae, Cacumen Platycladi, Radix Rhodiolae, Herba Ecliptae, Herba Hedyotidis Diffusae, Mahonia fortunei (Lindl.) Fedde, Radix Glycyrrhizae and respectively with Fructus Schisandrae Chinensis, Semen Juglandis that bundle ties, intense fire infusion 10-20 minute, fiery infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use; Step 4: by step 2, three gained filtrates and the mixing of step one gained powder, stir evenly, both the decoction of the slight bone marrow form acute radialion sickness for the treatment of of the present invention.
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| CN1663606A (en) * | 2003-12-31 | 2005-09-07 | 赵恒� | Medicine for treating radiation diseases |
| CN102389511A (en) * | 2011-11-22 | 2012-03-28 | 中国人民解放军第三军医大学第二附属医院 | Anti-radiation Chinese medicine preparation and preparation method thereof |
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