CN101632727A - Application of Chinese medicinal composition in preparing medicament for treating pulmonary hypertension - Google Patents
Application of Chinese medicinal composition in preparing medicament for treating pulmonary hypertension Download PDFInfo
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- CN101632727A CN101632727A CN200810055435A CN200810055435A CN101632727A CN 101632727 A CN101632727 A CN 101632727A CN 200810055435 A CN200810055435 A CN 200810055435A CN 200810055435 A CN200810055435 A CN 200810055435A CN 101632727 A CN101632727 A CN 101632727A
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Abstract
The invention discloses application of a Chinese medicinal composition in preparing a medicament for treating pulmonary hypertension. The Chinese medicinal composition comprises ginseng, leech, centipede, scorpion, ground beeltle, cicada slough, red paeony root, borneol and the like, and has the effects of invigorating Qi and activating blood, and dispersing blood stasis and dredging collateral. Clinical experiments prove that the Chinese medicinal composition can effectively treat the pulmonary hypertension.
Description
Technical field
The present invention relates to a kind of new purposes of Chinese medicine composition, specifically, the present invention relates to the application of a kind of Chinese medicine composition in the medicine of preparation treatment pulmonary hypertension.
Background technology
Pulmonary hypertension is that Different types of etiopathogenises causes, and increases to essence with pulmonary artery pressure and pulmonary vascular resistance, and getting involved with the lung blood vessel is starting point, is one group of Pathophysiology syndrome of terminal point with the right heart failure.
The World Health Organization (WHO) is divided into five classes according to the pathogenesis of pulmonary hypertension with it: 1, primary pulmonary hypertension; 2, familial pulmonary hypertension; 3. follow the pulmonary hypertension of relevant disease: 1. collagen vascular diseases; 2. left to right shunt type congenital heart disease; 3. portal hypertension; 4. HIV infects; 5. medicine and poisoning: appetrol, Oleum Brassicae campestris, L one tryptophan, methamphetamine, cocaine; 6. other: thyroid disease, I type glycogen storage disease, Gaucher disease, rendu-Osler-Weber disease, hemoglobinopathy, myeloproliferative disorder, splenectomy; 4. follow the pulmonary hypertension of tangible vein or blood capillary pathological changes: pulmonary venous obstruction disease, multiple pulmonary capillary tumor.5. persistant pulmonary hpertension of the neonate.
The cause of disease of pulmonary hypertension may be multiple factor, congenital lung small artery hypoplasia, multifactor lung blood vessel contracture, repeatedly Fa Zuo lung small artery thromboembolism or amniotic embolism, anoxia, autoimmune, gene, advance some fat-reducing of clothes or contraceptive, liver cirrhosis and portal hypertension and make vaso-active substance deactivation ability reduction etc. all may be the cause of disease.Pathologic finding shows flesh type lung small artery neointimal hyperplasia, but the hyperamization bolt forms, fibrosis, middle degraded layer or atrophy, cause tube chamber to stop up wholly or in part, near-end at vascular occlusion, flesh type small artery also can have middle level hypertrophy or fiber necrosis, and pulmonary artery is always done and branch enlarges, the right ventricle plumpness (Chen Haozhu. practical internal medicine. People's Health Publisher .1997 July the 10th edition).
The treatment of pulmonary hypertension mainly comprises: (one) etiological treatment; (2) general treatment: 1, suitable motion; 2, oxygen uptake; 3, diuretic; 4, Folium Digitalis Purpureae; 5, anticoagulant; (3) pulmonary artery dilation therapy: 1, calcium channel blocker; 2, prostacyclin class medicine; 3, endothelin-receptor antagonists; 4, other, NO etc.; 5, drug combination; (4) septostomy; (5) lung or cardiopulmonary inhibition (the Gong Fang relative. the progress of pulmonary hypertension. clinical the 23rd the 3rd phase of volume of department of pediatrics magazine .2005 .).
Pulmonary hypertension is a kind of common relatively disease, adopts western medicine, and untoward reaction is more relatively, and Chinese medicine has special advantages in the treatment pulmonary hypertension, is worth clinical application.
The present invention is the improvement invention of carrying out on the basis of No. 01131203.3 Chinese patent and No. 200410048292.2 patent application, quotes in full the content of this two patent documents record at this.The invention provides the new application of a kind of Chinese medicine composition in the medicine of preparation treatment pulmonary hypertension.
Summary of the invention
The object of the invention provides the application of a kind of Chinese medicine composition in the medicine of preparation treatment pulmonary hypertension.
Chinese medicine composition of the present invention is made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9
Lignum Dalbergiae Odoriferae 1-5 Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7
Semen Ziziphi Spinosae (stir-fry) 3-10;
Preferably, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5
Lignum Dalbergiae Odoriferae 2 Lignum Santali Albis 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendras 1 Borneolum Syntheticum 5
Semen Ziziphi Spinosae (stir-fry) 5;
Or:
Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 9 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5;
Or:
Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5;
The present invention also provides the active component of above-mentioned Chinese medicine composition to be made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
The invention also discloses that to contain above-mentioned Chinese medicine composition be capsule, tablet, pill, oral liquid, soft capsule or drop pill as the pharmaceutical preparation of active component.
In the Chinese medicine composition of the present invention, as the latin name of the crude drug of active component and processing method thereof from " Chinese medicine voluminous dictionary " (in July, 1977, front page, Shanghai science tech publishing house) and " Chinese pharmacopoeia (version in 2005, Chemical Industry Press).
Chinese medicine composition of the present invention can also be routinely preparation process, for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record, make the acceptable any conventional dosage form of pharmaceutics, for example capsule, tablet, pill, oral liquid, soft capsule, drop pill etc.
In the application of the present invention, described Chinese medicine composition is a kind of in capsule, tablet, pill, oral liquid, soft capsule, the dropping pill formulation, for above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.For making above-mentioned dosage form can realize pharmacy of Chinese materia medica, need when these dosage forms of preparation, to add acceptable other adjuvant of pharmacy (adjuvant of each dosage form record among the Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press December in 1997 the 1st edition).
Capsule of the present invention is preferably made by following preparation method: five kinds of Chinese medicine such as the Hirudo of said ratio, Scorpio, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra cleaned, and oven drying at low temperature, standby; Lignum Santali Albi, Lignum Dalbergiae Odoriferae extract volatile oil, and medicinal residues and aqueous solution are standby; Radix Ginseng extracts secondary with 70% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor; The medicinal residues of medicine residues of Radix Ginseng and Lignum Santali Albi, Lignum Dalbergiae Odoriferae merge with aqueous solution, add Radix Paeoniae Rubra, Semen Ziziphi Spinosae (stir-fry), decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.20-1.25 (60 ℃), add above-mentioned panaxynol extract, mixing, cold drying is ground into fine powder; The five tastes such as Olibanum (system) and Hirudo are ground into fine powder altogether; The Borneolum Syntheticum porphyrize, with above-mentioned fine powder facing-up, mixing sprays into volatile oil respectively, and mixing is granulated, and incapsulates, promptly.
Perhaps, capsule of the present invention is preferably made by following preparation method:
A) take by weighing each crude drug according to the weight portion ratio;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
Perhaps, capsule of the present invention is preferably made by following preparation method:
A) take by weighing each crude drug according to the weight portion ratio;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste, extractum directly is spray dried to spray powder;
D) preparation process:
The superfine powder flour is added in the Fluidbedgranulatingdrier with step c) gained spray drying powder, sprays solvent again and make granule; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
Amount of drug of the present invention is converted to the weight meter of crude drug, is each 0.8-3 gram, and take 2-4 every day, is preferably each 1.11-2.22 and restrains, and takes every day three times.
For illustrating the activity of traditional Chinese medicine composition for treating pulmonary hypertension of the present invention, with having carried out following experiment by the prepared medicine of embodiment 1 method (to call medicine of the present invention in the following text).
1 data and method
1.1 the whole cases of physical data all are selected from Hebei Yi Ling hospital inpatient, amount to 82 examples, are divided into treatment group and matched group at random, every group 41 example.Male 23 examples are organized in treatment, women 18 examples, between age 18-75 year, average (55.23 ± 7.05) year; The pulmonary hypertension type distribution: arterialness 22 examples, veins 4 examples, with respiratory system disease or anoxia dependency 13 examples, chronic thrombosis and (or) embolic 2 examples.Matched group man 22 examples, women 19 examples; Year mean age (56.02 ± 8.11); The pulmonary hypertension type distribution: arterialness 20 examples, veins 5 examples, with respiratory system disease or anoxia dependency 15 examples, chronic thrombosis and (or) embolic 1 example.Two groups sex, age and sick plant to learn by statistics aspect the distribution handle there was no significant difference (P＞0.05), have comparability.
1.2 case is selected inclusion criteria: (1) age 18-75 year, male or female; (2) diagnostic criteria that meets 1989 the 3rd national pulmonary heart disease cardiac function special meeting is formulated: horizontal breathe air on the sea level, pulmonary arterial systolic pressure under the quiescent condition (PASP)＞30mmHg, mean pulmonary arterial pressure (PAPm)＞20mmHg, perhaps PAPm＞30mmHg under the kinestate.Exclusion standard: (1) merges primary diseases such as cardiovascular, liver, kidney and hemopoietic system; (2) allergic constitution has allergies person to multiple medicine; (3) trimester of pregnancy or women breast-feeding their children.
1.3 the Therapeutic Method matched group adopts sldenafil treatment, 0.3g/ time, 3 times/day.The treatment group adds on matched group medication basis uses Drug therapy of the present invention, and 4/time, 3 times/day.Be for 4 weeks the course of treatment.
1.4 observation index: the variation of PASP and PAPm under the quiescent condition of observation treatment front and back.
1.5 statistical procedures adopts the SPSS13.0 statistical software to carry out date processing, (x ± s) expression adopts the t check to measurement data, and enumeration data adopts x with mean ± standard deviation
2Check.
2 results
2.1 the variation of PASP and PAPm under the quiescent condition
By statistics, behind two groups of patient treatments under the quiescent condition PASP and PAPm all be starkly lower than (P＜0.05) before the treatment; PASP and PAPm all are starkly lower than (P＜0.05) after the treatment of control group under the quiescent condition of treatment group treatment back.The results are shown in Table 1.
Table 1 liang group patient PASP and PAPm comparison (x ± s)
Annotate: with treatment is relatively preceding on the same group, * P＜0.05; With comparison after the treatment of control group, #P＜0.05.
3 conclusions
This research is on the basis of doctor trained in Western medicine conventional therapy, add Drug therapy of the present invention, aspects such as pulmonary arterial systolic pressure and mean pulmonary arterial pressure all are better than simple western medical treatment under the reduction quiescent condition, confirm that fully medicine of the present invention has significant clinical efficacy to pulmonary hypertension.
The specific embodiment
Embodiment 1: the preparation of capsule
A) the crude drug prescription is:
Radix Ginseng 39.6g Hirudo 72.6g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 19.8g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 30-40 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, and each 3 hours, merge decocting liquid, after the water extract filters, extractum to be condensed into; Radix Ginseng is with an amount of 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, the reuse water extraction, alcohol extract is condensed into 60 ℃, and to measure relative densities be 0.9～1.1 alcohol-extracted extract, the water extract filter with above-mentioned all water extract mixings after be concentrated into 60 ℃ to measure relative densities be 0.9～1.1 clear paste, standby;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make 1000 capsules behind the mixing.
Amount of drug of the present invention for each 2-4 grain, is taken three times every day.
Embodiment 2: the preparation of tablet
A) the crude drug prescription is:
Radix Ginseng 66g Hirudo 52.8g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 59.4g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 70-90 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, and each 3 hours, merge the water extract, after the filtration, extractum to be condensed into; Radix Ginseng is with an amount of 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, the reuse water extraction, alcohol extract is condensed into relative density and is determined as 1.0～1.05 alcohol-extracted extracts at 60 ℃, the water extract filter with above-mentioned all water extract mixings after be concentrated into 60 ℃ to measure relative densities be 1.0～1.1 clear paste, standby;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, preparation process is pressed into 1000 routinely.
Amount of drug of the present invention for each 2-4 sheet, is taken three times every day.
Embodiment 3: the preparation of pill
A) the crude drug prescription is:
Radix Ginseng 39.6g Hirudo 66g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 46.2g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes medicated powder mean diameter 10-20 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, and each 3 hours, merge the water extract, after the filtration, extractum to be condensed into; Radix Ginseng is with an amount of 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, the reuse water extraction, alcohol extract is condensed into 60 ℃, and to measure relative densities be 0.9～1.0 alcohol-extracted extract, the water extract filter with above-mentioned all water extract mixings after be concentrated into 60 ℃ to measure relative densities be 1.0～1.1 clear paste, standby;
D) preparation process:
Preparation process is made 1000 pills routinely.
Amount of drug of the present invention for each 2-4 grain, is taken three times every day.
Claims (8)
1. the application of Chinese medicine composition in the medicine of preparation treatment pulmonary hypertension, it is characterized in that: described Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9
Lignum Dalbergiae Odoriferae 1-5 Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7
Semen Ziziphi Spinosae (stir-fry) 3-10.
2. application as claimed in claim 1 is characterized in that: described Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
3. application as claimed in claim 1 is characterized in that: described Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 9 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
4. application as claimed in claim 1 is characterized in that: described Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
5. as each described application among the claim 1-4, it is characterized in that: the active component of described Chinese medicine composition is made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
6. as each described application among the claim 1-4, it is characterized in that: the preparation formulation of described Chinese medicine composition is capsule, tablet, pill, oral liquid, soft capsule or drop pill.
7. according to the preparation method of the described medicine capsule of claim 6, it is characterized in that it is made by following steps:
A) take by weighing each crude drug according to the weight portion ratio;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
According to the preparation method of the described medicine capsule of claim 6, it is characterized in that 8, it is made by following steps:
A) take by weighing each crude drug according to the weight portion ratio;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste, extractum directly is spray dried to spray powder;
D) preparation process:
The superfine powder flour is added in the Fluidbedgranulatingdrier with step c) gained spray drying powder, sprays solvent again and make granule; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
Priority Applications (1)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102210758A (en) * | 2010-04-08 | 2011-10-12 | 河北以岭医药研究院有限公司 | Application of Chinese medicine composition in preparation of medicine for treating ankylosing spondylitis |
| CN104815232A (en) * | 2015-05-06 | 2015-08-05 | 谢璞 | Traditional Chinese medicine preparation for treating primary pulmonary hypertension and preparation method thereof |
| CN114432375A (en) * | 2020-10-30 | 2022-05-06 | 吴京波 | Traditional Chinese medicine composition for treating plateau pulmonary hypertension |
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| CN1305490C (en) * | 2004-06-18 | 2007-03-21 | 河北以岭医药研究院有限公司 | Supermicro heart-meridians-activating Chinese medicine composition and its preparing method |
| CN1939438B (en) * | 2005-09-29 | 2010-05-05 | 河北以岭医药研究院有限公司 | Chinese medicinal composition, its extract containing insect and its preparation |
| CN1954825B (en) * | 2005-10-26 | 2011-09-14 | 河北以岭医药研究院有限公司 | Supermicro Tongxinluo Chinese herbal composite and its new usage |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210758A (en) * | 2010-04-08 | 2011-10-12 | 河北以岭医药研究院有限公司 | Application of Chinese medicine composition in preparation of medicine for treating ankylosing spondylitis |
| CN104815232A (en) * | 2015-05-06 | 2015-08-05 | 谢璞 | Traditional Chinese medicine preparation for treating primary pulmonary hypertension and preparation method thereof |
| CN114432375A (en) * | 2020-10-30 | 2022-05-06 | 吴京波 | Traditional Chinese medicine composition for treating plateau pulmonary hypertension |
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