CN104873676A - Traditional Chinese medicine for treating qi-blood deficiency type diabetic foot ulcer - Google Patents

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine for treating qi-blood deficiency type diabetic foot ulcer. The traditional Chinese medicine is prepared by the following raw materials in part by weight: 8-16 parts of ginseng, 8-16 parts of astragalus membranaceus, 8-16 parts of bighead atractylodes rhizome, 16-24 parts of prepared rehmannia root, 8-16 parts of angelica sinensis, 4-8 parts of colla corii asini, 8-16 parts of frankincense, 8-16 parts of myrrh, 2-4 parts of acacia catechu, 8-16 parts of moutan bark, 5-13 parts of rhizoma alismatis, and 4-8 parts of liquorice. The traditional Chinese medicine can effectively shorten the wound surface area, and improve syndrome of Chinese medicine; the traditional Chinese medicine is high in both significant efficiency and total effective rate.

Description

A kind of Chinese medicine for the treatment of QIXUELIANGXU type diabetic foot ulcer

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of QIXUELIANGXU type diabetic foot ulcer.

Background technology

The generation of diabetic foot (DF) is the large coefficient result of factor of neuropathy, vascular lesion and infection three mainly, and affected area can deeply and bone and joint, and finally cause the necrosis of foot, the life security of diabetics in serious threat.According to external, about there is the diabetics of 1.5 hundred million in the whole world, what wherein occur that diabetic foot bursts disease or gangrene about has 15%, in annual non-wound patients with amputation, have 50% for patient with diabetic feet, and about have in the patient with diabetic feet of these amputation 80% because foot is burst disease deal with improperly and cause.Therefore active treatment diabetic foot, promote ulcer surface healing, reduce the emphasis that amputation rate is treatment diabetic foot.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, there is provided a kind of Chinese medicine for the treatment of QIXUELIANGXU type diabetic foot ulcer, this Chinese medicine can effectively reduce wound surface area, improves TCM syndrome, there is cure rate high, the advantage that obvious effective rate is high.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for QIXUELIANGXU type diabetic foot ulcer, be made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Ginseng 8-16 part, Radix Astragali 8-16 part, Rhizoma Atractylodis Macrocephalae 8-16 part, Radix Rehmanniae Preparata 16-24 part, Radix Angelicae Sinensis 8-16 part, Colla Corii Asini 4-8 part, Olibanum 8-16 part, Myrrha 8-16 part, catechu 2-4 part, Cortex Moutan 8-16 part, Rhizoma Alismatis 5-13 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine of above-mentioned treatment QIXUELIANGXU type diabetic foot ulcer, be made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Ginseng 10-14 part, Radix Astragali 10-14 part, Rhizoma Atractylodis Macrocephalae 10-14 part, Radix Rehmanniae Preparata 18-22 part, Radix Angelicae Sinensis 10-14 part, Colla Corii Asini 5-7 part, Olibanum 10-14 part, Myrrha 10-14 part, catechu 2.5-3.5 part, Cortex Moutan 10-14 part, Rhizoma Alismatis 7-11 part, Radix Glycyrrhizae 5-7 part.

Preferred, the Chinese medicine of above-mentioned treatment QIXUELIANGXU type diabetic foot ulcer, be made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Ginseng 12 parts, the Radix Astragali 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Rehmanniae Preparata 20 parts, Radix Angelicae Sinensis 12 parts, 6 parts, Colla Corii Asini, Olibanum 12 parts, Myrrha 12 parts, 3 parts, catechu, Cortex Moutan 12 parts, Rhizoma Alismatis 9 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

Chinese medicine of the present invention has effect of benefiting vital QI and blood, promoting blood circulation and stopping pain, promoting tissue regeneration and ulcer healing, is applicable to QIXUELIANGXU type diabetic foot ulcer.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

Diabetic foot ulcer disease does not heal for a long time, QI and blood deficiency, and limbs lose supports, then skin ulcer face obstinate, and yellowish pink is not fresh, emaciated physique; Deficiency of qi and blood, then fatigue and weakness; The deficiency of vital energy promotes unable, qi depression to blood stasis, stagnation of QI and blood may bring about pain, then suffer from toe pain; Temper virtual loss, then loss of appetite; Light red tongue, few tongue, thready pulse without strength are resembling of QI and blood deficiency.Therefore " deficiency of qi and blood " is the key factor in primary disease pathogenic process, need focus on benefiting vital QI and blood during treatment.

Chinese medicine of the present invention with benefiting vital QI and blood, promoting blood circulation and detumescence pain relieving, promoting tissue regeneration and ulcer healing for primary efficacy.

The prescription mechanism of Chinese medicine of the present invention is as follows:

Monarch drug: Radix Ginseng, the Radix Astragali, Rhizoma Atractylodis Macrocephalae merit are with air making-up and spleen enlivening; The Radix Astragali can ask skin ulcer granulation promoting to be the panacea of persons particularly liable to develop skin infection; Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Colla Corii Asini merit are with nourishing YIN and supplementing blood, and Radix Angelicae Sinensis has effect of promoting blood circulation and stopping pain concurrently; Six medicines are monarch drug altogether.QI and blood is prosperous, and muscles is foster to some extent.

Ministerial drug: Olibanum, Myrrha, catechu merit are with promoting blood circulation, dredging meridian and relieving pain, and detumescence and promoting granulation sore is ministerial drug.

Adjuvant drug: Rhizoma Alismatis merit expels the heat-evil with promoting diuresis to eliminate damp pathogen, Cortex Moutan merit is invigorated blood circulation with clearing away heat and cooling blood, tonic in common using corrigent monarch drug, prevents growing the greasy stomach that hinders and loves heresy.

Make medicine: Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share the effect of playing benefiting vital QI and blood, promoting blood circulation and detumescence pain relieving, promoting tissue regeneration and ulcer healing altogether.Link closely diabetic foot ulcer (QIXUELIANGXU type) etiology and pathogenesis, can effectively reduce wound surface area, improve TCM syndrome, achieve good clinical efficacy, be worthy to be popularized.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine for QIXUELIANGXU type diabetic foot ulcer, each crude drug weight proportion is as follows:

Radix Ginseng 12g, Radix Astragali 12g, Rhizoma Atractylodis Macrocephalae 12g, Radix Rehmanniae Preparata 20g, Radix Angelicae Sinensis 12g, Colla Corii Asini 6g, Olibanum 12g, Myrrha 12g, catechu 3g, Cortex Moutan 12g, Rhizoma Alismatis 9g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine for QIXUELIANGXU type diabetic foot ulcer, each crude drug weight proportion is as follows:

Radix Ginseng 10g, Radix Astragali 14g, Rhizoma Atractylodis Macrocephalae 10g, Radix Rehmanniae Preparata 22g, Radix Angelicae Sinensis 10g, Colla Corii Asini 7g, Olibanum 10g, Myrrha 14g, catechu 2.5g, Cortex Moutan 10g, Rhizoma Alismatis 11g, Radix Glycyrrhizae 5g.

Embodiment 3

Treat a Chinese medicine for QIXUELIANGXU type diabetic foot ulcer, each crude drug weight proportion is as follows:

Radix Ginseng 14g, Radix Astragali 10g, Rhizoma Atractylodis Macrocephalae 14g, Radix Rehmanniae Preparata 18g, Radix Angelicae Sinensis 14g, Colla Corii Asini 5g, Olibanum 14g, Myrrha 10g, catechu 3.5g, Cortex Moutan 14g, Rhizoma Alismatis 7g, Radix Glycyrrhizae 7g.

Embodiment 4

Treat a Chinese medicine for QIXUELIANGXU type diabetic foot ulcer, each crude drug weight proportion is as follows:

Radix Ginseng 8g, Radix Astragali 16g, Rhizoma Atractylodis Macrocephalae 8g, Radix Rehmanniae Preparata 24g, Radix Angelicae Sinensis 8g, Colla Corii Asini 8g, Olibanum 8g, Myrrha 16g, catechu 2g, Cortex Moutan 8g, Rhizoma Alismatis 13g, Radix Glycyrrhizae 4g.

Embodiment 5

Treat a Chinese medicine for QIXUELIANGXU type diabetic foot ulcer, each crude drug weight proportion is as follows:

Radix Ginseng 16g, Radix Astragali 8g, Rhizoma Atractylodis Macrocephalae 16g, Radix Rehmanniae Preparata 16g, Radix Angelicae Sinensis 16g, Colla Corii Asini 4g, Olibanum 16g, Myrrha 8g, catechu 4g, Cortex Moutan 16g, Rhizoma Alismatis 5g, Radix Glycyrrhizae 8g.

Carried out clinical pharrnacokinetics test to treatment QIXUELIANGXU type diabetic foot ulcer Chinese medicine of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose diabetic foot ulcer patient totally 150 examples.

1.1.1 diagnostic criteria

The diagnostic criteria of diabetic foot ulcer: the diagnostic criteria of formulating with reference to first the diabetic foot meeting of nineteen ninety-five Chinese Medical Association: (1) have clear and definite diabetic history; (2) foot has the wound surface such as ulcer or gangrene, and clinical manifestation is local erosion, ulcer, necrosis, wound surface is prolonged does not heal.

1.1.2 TCM syndrome diagnostic criteria

Differentiation of symptoms and signs for classification of syndrome standard and " new Chinese medicine guideline of clinical investigations " with reference to necrosis in " People's Republic of China's traditional Chinese medicine industry standard-Chinese medical disease Standardization of diagnosis and curative effect ":

QIXUELIANGXU type: the QI and blood deficiency course of disease with the passing of time, skin ulcer face disunion of a specified duration after slough comes off, granulation is dark red or light and not fresh; Suffer from toe pain, fatigue and weakness, loss of appetite, lustreless complexion, emaciated physique; Light red tongue, few tongue, thready pulse without strength.

1.1.3 inclusive criteria

(1) meet the diagnostic criteria of diabetic foot ulcer:

(2) Syndrome Differentiation of Traditional Chinese Medicine belongs to QIXUELIANGXU type person;

(3) the age is between 18-75 year, not sex-limited, the actute infection patient of wound area≤30cm2;

(4) glycemic control is good, wherein fasting glucose≤7mmol/L, post-prandial glycemia≤l0mmol/L person;

(5) all Informed Consent Form is signed.

1.1.4 exclusion standard

(1) suffer from ischemic ulcer, carcinous and tuberculous ulcer person;

(2) infect and cause General Symptoms (body temperature >38 DEG C, leukocyte >11x109, the person that need use antibiotics;

(3) merge the internal medicine underlying diseases such as the serious heart, brain, liver, kidney and respiratory system, need stable vital sign person; Gestation, women breast-feeding their children; Mental disorder, hereditary person; Serious hypoproteinemia person;

(4) allergic constitution person or to this drugs allergy sufferers.

1.2 method

1.2.1 Therapeutic Method

Oral Chinese medicine decoction, effect is benefiting vital QI and blood, promoting blood circulation and stopping pain, promoting tissue regeneration and ulcer healing.Prescription is as follows: Radix Ginseng 12g, Radix Astragali 12g, Rhizoma Atractylodis Macrocephalae 12g, Radix Rehmanniae Preparata 20g, Radix Angelicae Sinensis 12g, Colla Corii Asini 6g, Olibanum 12g, Myrrha 12g, catechu 3g, Cortex Moutan 12g, Rhizoma Alismatis 9g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, day potion, sooner or later sub-service, is used in conjunction 1 month.

1.2.2 observation index

Observe wound surface area and Chinese medicine syndrome integral change before and after treatment

With photo shop computed in software area after wound surface area adopts digital camera to take.

TCM syndrome evaluation standard: with reference to " People's Republic of China's traditional Chinese medicine industry standard-Chinese medical disease Standardization of diagnosis and curative effect ".

1.2.1 criterion of therapeutical effect

" the surgery of Chinese medicine disease Standardization of diagnosis and curative effect " promulgated with reference to nineteen ninety-five State Administration of Traditional Chinese Medicine is formulated

(1) fully recover: wound healing or substantially heal, syndrome integral reduces between 90%-100% (containing 90%).

(2) effective: wound surface area reduces >50%, and granulation tissue is light red, without pus, the red and swollen obviously disappearance of wound week, pain alleviates substantially, and syndrome integral reduces between 60%-90% (containing 60%).

(3) effective: wound surface area is reduced into 20%-50% (containing 50%), and granulation tissue is scarlet, can have a small amount of pus, wound week is slightly red and swollen, and syndrome integral reduces between 30%-60% (containing 30%).

(4) invalid: wound surface area reduces <20% or even increases the weight of without significant change, syndrome integral minimizing is less than 30%.

Note: integration x100% before syndrome integral minification=(before treatment the rear integration of integration-treatment)/treatment

Long-pending x100% before wound surface area minification=(long-pending after long-pending before treatment-treatment)/treatment

Total obvious effective rate=cure rate+obvious effective rate

Total effective rate=cure rate+obvious effective rate+effective percentage

2. result

Treat after two weeks in 150 routine diabetic foot ulcer patients, 74 examples of fully recovering (49.3%), effective 62 examples (41.3%), effective 10 examples (6.7%), invalid 4 examples (2.7%); Cure rate 49.3%, total obvious effective rate 90.6%, total effective rate 97.3%.

Claims (3)

1. treat a Chinese medicine for QIXUELIANGXU type diabetic foot ulcer, be made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Ginseng 8-16 part, Radix Astragali 8-16 part, Rhizoma Atractylodis Macrocephalae 8-16 part, Radix Rehmanniae Preparata 16-24 part, Radix Angelicae Sinensis 8-16 part, Colla Corii Asini 4-8 part, Olibanum 8-16 part, Myrrha 8-16 part, catechu 2-4 part, Cortex Moutan 8-16 part, Rhizoma Alismatis 5-13 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine for the treatment of QIXUELIANGXU type diabetic foot ulcer according to claim 1, is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Ginseng 10-14 part, Radix Astragali 10-14 part, Rhizoma Atractylodis Macrocephalae 10-14 part, Radix Rehmanniae Preparata 18-22 part, Radix Angelicae Sinensis 10-14 part, Colla Corii Asini 5-7 part, Olibanum 10-14 part, Myrrha 10-14 part, catechu 2.5-3.5 part, Cortex Moutan 10-14 part, Rhizoma Alismatis 7-11 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine for the treatment of treatment QIXUELIANGXU type diabetic foot ulcer according to claim 2, is characterized in that, be made up of the raw material of Chinese medicine medicine of following weight portion:

Radix Ginseng 12 parts, the Radix Astragali 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Rehmanniae Preparata 20 parts, Radix Angelicae Sinensis 12 parts, 6 parts, Colla Corii Asini, Olibanum 12 parts, Myrrha 12 parts, 3 parts, catechu, Cortex Moutan 12 parts, Rhizoma Alismatis 9 parts, 6 parts, Radix Glycyrrhizae.