CN103405573B - One treats the strong bone formula of osteoporotic bone pine and preparation technology thereof - Google Patents
One treats the strong bone formula of osteoporotic bone pine and preparation technology thereof Download PDFInfo
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Abstract
The present invention relates generally to one and treats the strong bone formula of osteoporotic bone pine and preparation technology thereof, described formula according to parts by weight by crude drug Radix Rehmanniae Preparata 12-18 part, Fructus Corni 13-17 part, Radix Angelicae Sinensis 10-14 part, Herba Epimedii 14-16 part, Semen Cuscutae 10-14 part, Fructus Lycii 10-14 part, Rhizoma Atractylodis Macrocephalae 11-13 part and Pheretima 11-13 part composition, the strong bone formula of bone pine effectively can treat constitutional, secondary osteoporosis and osteomalacia, show as the back or the aching and tired pain of whole body of being caused by deficiency of the kidney yin blood stasis, limbs fatigue, legs and feet knot, numb hand and foot, irritable, palpitation and insomnia, roars of laughter febrile perspiration goes out, red tongue, yellow fur, there is crackle, the symptoms such as thready and rapid pulse are evident in efficacy, decline to preventing bone density, reduce bone conversion, improve balanced capacity successful.Preparation technology of the present invention is simple, and production cost is low, and the strong bone prescription drug Be very effective of bone pine prepared, is suitable for applying.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to one and treat the strong bone formula of osteoporotic bone pine and preparation technology thereof.
Background technology
Osteoporosis is the common frequently-occurring diseases of person in middle and old age, is a kind of sclerotin degenerative states, be, the minimizing of bone amount impaired with the loss of calcium in bone, osseous tissue microstructure, thinning, the bone fragility of sclerotin increase and risk of bone fracture degree to raise be the sclerotin change of feature.Osteoporosis is mainly divided into constitutional and Secondary cases, and its basic pathology mechanism is that in bone metabolism process, defect appears in bone resorption and osteoplastic coupling, causes alcium and phosphor metabolization in human body uneven, bone density is reduced gradually and the clinical symptoms that causes.Clinical manifestation is pain, and height shortens, hunchback, fracture, respiratory function declines, these symptoms bring great misery to patient, also bring a lot of inconvenience to life, and take Western medicine during treatment, as estrogen, calcitonin etc., not only uncertain therapeutic efficacy is cut, and treatment cost is high, cures the symptoms, not the disease, curative effect is undesirable, and relapse rate is high.
Summary of the invention
The object of this invention is to provide one and treat the strong bone formula of osteoporotic bone pine and preparation technology thereof, the strong bone formula of this bone pine has nourishing the liver and kidney, benefiting essence and marrow, disperse blood stasis and dredge collateral, effect of bone strengthening pain relieving, can effectively treat constitutional, secondary osteoporosis, back or the aching and tired pain of whole body, limbs fatigue, legs and feet cramp, numb hand and foot, irritable, palpitation and insomnia, roars of laughter febrile perspiration are gone out, red tongue, yellow fur, tongue have the disease such as crackle, thready and rapid pulse Be very effective.
The technical scheme that the present invention realizes above-mentioned purpose employing is: one treats the strong bone formula of osteoporotic bone pine, and described formula is made up of crude drug Radix Rehmanniae Preparata 12-18 part, Fructus Corni 13-17 part, Radix Angelicae Sinensis 10-14 part, Herba Epimedii 14-16 part, Semen Cuscutae 10-14 part, Fructus Lycii 10-14 part, Rhizoma Atractylodis Macrocephalae 11-13 part and Pheretima 11-13 part according to parts by weight.
Treat a preparation technology for the strong bone formula of osteoporotic bone pine, comprise the following steps:
Step one, get crude drug Radix Rehmanniae Preparata 12-18 part, Fructus Corni 13-17 part, Radix Angelicae Sinensis 10-14 part, Herba Epimedii 14-16 part, Semen Cuscutae 10-14 part, Fructus Lycii 10-14 part, Rhizoma Atractylodis Macrocephalae 11-13 part and Pheretima 11-13 part according to parts by weight, for subsequent use;
Step 2, get Herba Epimedii that step one obtains and Semen Cuscutae is placed in decocting device, the water adding Herba Epimedii and Semen Cuscutae gross weight 10 times again decocts, medicinal liquid is leached after decocting 2h, then in medicinal residues, the continuous water adding Herba Epimedii and Semen Cuscutae gross weight 8 times decocts 1.5h again, filters to obtain medicinal liquid, discards medicinal residues, merge twice medicinal liquid, being concentrated into relative density under medicinal liquid 80 DEG C of conditions is 1.03, obtains concentrated solution, for subsequent use;
Step 3, the Radix Rehmanniae Preparata that step one is obtained, Fructus Corni, Radix Angelicae Sinensis, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae and Pheretima, mixing is placed in super micron mill and pulverizes, and pulverizes after terminating and takes out 200 mesh sieves, obtain Chinese medicinal powder, for subsequent use;
The Chinese medicinal powder that step 4, the concentrated solution and the step 3 that step 2 are obtained obtain mixes, and then carries out preparation, i.e. the preparation of the strong bone formula of completed treatment osteoporotic bone pine.
Beneficial effect of the present invention
One, one provided by the invention treat the strong bone formula of osteoporotic bone pine can effectively treat constitutional, secondary osteoporosis and osteomalacia, shows as the back or the aching and tired pain of whole body of being caused by deficiency of the kidney yin blood stasis, limbs fatigue, legs and feet knot, numb hand and foot, irritable, palpitation and insomnia, roars of laughter febrile perspiration goes out, red tongue, yellow fur, have crackle, the symptoms such as thready and rapid pulse are evident in efficacy, decline to preventing bone density, reduce bone conversion, improve balanced capacity successful.
Two, preparation technology of the present invention is simple, and production cost is low, and in technique, Herba Epimedii and Semen Cuscutae decoct, and extract the effective ingredient in medical material, the two is in conjunction with main tonifying kidney-yin, bone and muscle strengthening comprehensively; Radix Rehmanniae Preparata, Fructus Corni, Radix Angelicae Sinensis, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae and Pheretima are mixed and made into powder, the mutual compatibility master of mixed-powder enrich blood invigorate blood circulation, current meridians, liver and kidney tonifying, and these powder enter drug effect after human body plays Be very effective, and effective ingredient in high temperature decoction process can be avoided to run off, therefore mix decocting the concentrated solution obtained with Chinese medicinal powder again, the bone pine prepared is good for, and bone prescription drug bioavailability is high, drug effect is more remarkable, is suitable for applying.
Detailed description of the invention
One treats the strong bone formula of osteoporotic bone pine, and described formula is made up of crude drug Radix Rehmanniae Preparata 12-18 part, Fructus Corni 13-17 part, Radix Angelicae Sinensis 10-14 part, Herba Epimedii 14-16 part, Semen Cuscutae 10-14 part, Fructus Lycii 10-14 part, Rhizoma Atractylodis Macrocephalae 11-13 part and Pheretima 11-13 part according to parts by weight.
Treat a preparation technology for the strong bone formula of osteoporotic bone pine, comprise the following steps:
Step one, get crude drug Radix Rehmanniae Preparata 12-18 part, Fructus Corni 13-17 part, Radix Angelicae Sinensis 10-14 part, Herba Epimedii 14-16 part, Semen Cuscutae 10-14 part, Fructus Lycii 10-14 part, Rhizoma Atractylodis Macrocephalae 11-13 part and Pheretima 11-13 part according to parts by weight, for subsequent use;
Step 2, get Herba Epimedii that step one obtains and Semen Cuscutae is placed in decocting device, the water adding Herba Epimedii and Semen Cuscutae gross weight 10 times again decocts, medicinal liquid is leached after decocting 2h, then in medicinal residues, the continuous water adding Herba Epimedii and Semen Cuscutae gross weight 8 times decocts 1.5h again, filters to obtain medicinal liquid, discards medicinal residues, merge twice medicinal liquid, being concentrated into relative density under medicinal liquid 80 DEG C of conditions is 1.03, obtains concentrated solution, for subsequent use;
Step 3, the Radix Rehmanniae Preparata that step one is obtained, Fructus Corni, Radix Angelicae Sinensis, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae and Pheretima, mixing is placed in super micron mill and pulverizes, and pulverizes after terminating and takes out 200 mesh sieves, obtain Chinese medicinal powder, for subsequent use;
The Chinese medicinal powder that step 4, the concentrated solution and the step 3 that step 2 are obtained obtain mixes, and then carries out preparation, i.e. the preparation of the strong bone formula of completed treatment osteoporotic bone pine.
below in conjunction with specific embodiment, the present invention will be further described:
embodiment 1:
One treats the strong bone formula of osteoporotic bone pine, and described formula is made up of 18 parts, crude drug Radix Rehmanniae Preparata, Fructus Corni 13 parts, Radix Angelicae Sinensis 10 parts, Herba Epimedii 14 parts, Semen Cuscutae 10 parts, Fructus Lycii 10 parts, the Rhizoma Atractylodis Macrocephalae 11 parts and Pheretima 11 parts according to parts by weight.
Treat a preparation technology for the strong bone formula of osteoporotic bone pine, comprise the following steps:
Step one, get crude drug Radix Rehmanniae Preparata, Fructus Corni, Radix Angelicae Sinensis, Herba Epimedii, Semen Cuscutae, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae and Pheretima according to the parts by weight in above-mentioned formula, for subsequent use;
Step 2, get Herba Epimedii that step one obtains and Semen Cuscutae is placed in decocting device, the water adding Herba Epimedii and Semen Cuscutae gross weight 10 times again decocts, medicinal liquid is leached after decocting 2h, then in medicinal residues, the continuous water adding Herba Epimedii and Semen Cuscutae gross weight 8 times decocts 1.5h again, filters to obtain medicinal liquid, discards medicinal residues, merge twice medicinal liquid, being concentrated into relative density under medicinal liquid 80 DEG C of conditions is 1.03, obtains concentrated solution, for subsequent use;
Step 3, the Radix Rehmanniae Preparata that step one is obtained, Fructus Corni, Radix Angelicae Sinensis, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae and Pheretima, mixing is placed in super micron mill and pulverizes, and pulverizes after terminating and takes out 200 mesh sieves, obtain Chinese medicinal powder, for subsequent use;
The general ball of Chinese medicinal powder that step 4,80% and the step 3 of concentrated solution that first obtain by step 2 obtain, general ball diameter is 5-6mm, then drying under the condition of 80 DEG C is being no more than, the concentrated solution polishing of the dry ball residue 20% that drying obtains, be no more than drying under the condition of 60 DEG C again, i.e. obtained treatment osteoporotic bone pine bolus for reinforcing bones of human body agent, the name of product of batch production is " bone pine bolus for reinforcing bones of human body ".
embodiment 2:
One treats the strong bone formula of osteoporotic bone pine, and described formula is made up of 12 parts, crude drug Radix Rehmanniae Preparata, Fructus Corni 17 parts, Radix Angelicae Sinensis 14 parts, Herba Epimedii 16 parts, Semen Cuscutae 14 parts, Fructus Lycii 14 parts, the Rhizoma Atractylodis Macrocephalae 13 parts and Pheretima 13 parts according to parts by weight.
A kind of preparation technology treating the strong bone formula of osteoporotic bone pine, the preparation of concentrated solution and Chinese medicinal powder is with embodiment 1, the Chinese medicinal powder of preparation is placed in blender, then add concentrated solution, low whipping speed is mix 4-6 time under the condition of 28r/min, each 7-9min, after mix homogeneously, cross 14 mesh sieves to granulate, after oven dry, with 16 mesh sieve granulate; Loaded by granule after granulate in capsulae vacuus, i.e. obtained treatment osteoporotic bone pine Jiangu capsule for strengthening bone, the name of product of batch production is " bone pine Jiangu capsule for strengthening bone ".
embodiment 3:
One treats the strong bone formula of osteoporotic bone pine, and described formula is made up of 15 parts, crude drug Radix Rehmanniae Preparata, Fructus Corni 15 parts, Radix Angelicae Sinensis 12 parts, Herba Epimedii 15 parts, Semen Cuscutae 12 parts, Fructus Lycii 12 parts, the Rhizoma Atractylodis Macrocephalae 12 parts and Pheretima 12 parts according to parts by weight.
A kind of preparation technology treating the strong bone formula of osteoporotic bone pine, the Chinese medicinal powder of preparation, with embodiment 1, is placed in blender, then adds concentrated solution by the preparation of concentrated solution and Chinese medicinal powder, low whipping speed is mix 4-6 time under the condition of 28r/min, each 7-9min, after mix homogeneously, crosses 14 mesh sieves and granulates, dry obtained soft material, by obtained soft material tabletting machine, i.e. the strong osteocomma agent of obtained treatment osteoporotic bone pine, the name of product of batch production is " the strong osteocomma of bone pine ".
clinical testing data
The bone pine bolus for reinforcing bones of human body prepared for embodiment 1 carries out the clinical trial about curative effect, and the instructions of taking of Chinese medicine bolus for reinforcing bones of human body is twice on the one, a 6g, within 15th, is a course for the treatment of:
78 routine patients are selected in osteoporosis section of Henan Luoyang Bone Setting Hospital, patient suffers from constitutional respectively, secondary osteoporosis and osteomalacia, show as the back or the aching and tired pain of whole body of being caused by deficiency of the kidney yin blood stasis, limbs fatigue, legs and feet knot, numb hand and foot, irritable, palpitation and insomnia, roars of laughter febrile perspiration goes out, red tongue, yellow fur, there is crackle, the symptoms such as thready and rapid pulse, having 48 examples to take the osteoporotic Chinese medicine bolus for reinforcing bones of human body for the treatment of provided by the invention in 78 routine patients is test group, it is matched group that 30 routine patients take the osteoporotic similar medicine for the treatment of, other treatment environment is just the same.
Test group and treatment of control group carried out therapeutic effect analysis after four months, and result is as follows:
One, Comparison of therapeutic before and after treatment
Criterion of therapeutical effect:
Effective: back or the aching and tired pain of whole body, limbs fatigue, legs and feet knot, numb hand and foot, irritable, palpitation and insomnia, and roars of laughter febrile perspiration goes out, red tongue, and yellow fur, has crackle, and the symptoms such as thready and rapid pulse disappear substantially;
Effective: back or the aching and tired pain of whole body, limbs fatigue, legs and feet knot, numb hand and foot, irritable, palpitation and insomnia, and roars of laughter febrile perspiration goes out, red tongue, and yellow fur, has crackle, and the symptoms such as thready and rapid pulse obviously alleviate;
Invalid: above symptom is all obviously alleviated.
Through statistics, result is as shown in table 1:
Table 1:
As shown in Table 1, the obvious effective rate of the strong bone formula of bone pine provided by the invention is 18.75%, total effective rate 89.58%, and the obvious effective rate of matched group is 16.67%, total effective rate 86.67%; Illustrate that the strong bone formula of bone pine effectively can improve back or the aching and tired pain of whole body of patient, limbs fatigue, legs and feet knot, numb hand and foot, irritable, palpitation and insomnia, roars of laughter febrile perspiration goes out, red tongue, yellow fur, has crackle, and the symptoms such as thready and rapid pulse prevent bone density from declining, and more remarkable treatment effect.
Two, the osteodynia scoring before and after test group and treatment of control group, tcm clinical practice symptom score and the scoring of Berg balance scale are compared, and statistical result is as shown in table 2:
Table 2:
As shown in Table 2, osteodynia scoring, the scoring of tcm clinical practice symptom score, Berg balance scale of test group improve obviously, illustrate that the strong bone formula of bone pine effectively can improve patient pain and various clinical symptoms, improve balanced capacity, evident in efficacy.
Three, skeleton metabolism mutation analysis (bone alkaline phosphatase (BALP), NTx are cross-linked C and hold peptide (β-CTX) to compare) before and after test group and treatment of control group, statistical result is as shown in table 3:
Table 3:
As shown in Table 3, experiment group B ALP declines comparatively obvious, and after medication is described, calcium precipitation increases, and the β-CTX of test group declines obviously, namely the strong bone formula of bone pine effectively can suppress bone resorption, illustrates that the strong bone formula of bone pine effectively can reduce the bone that deficiency of the kidney yin syndrome of blood stasis causes and change.
Four, the bone density mutation analysis before and after test group and treatment of control group, according to the performance of skeleton x line, clinical judgment is effective, effective and invalid, and through statistics, result is as shown in table 4:
Table 4:
As shown in Table 4, the obvious effective rate of test group is 14.58%, total effective rate 89.58%; Illustrate that the strong bone formula efficiency of bone provided by the invention pine prevents bone density from declining, and evident in efficacy.
Five, the fragility fractures Incidence before and after test group and treatment of control group, through statistics, result is as shown in table 5:
Table 5:
As shown in Table 5, after treatment, the incidence of fracture of test group obviously declines, and the strong bone formula of bone pine can effectively reduce fragility fractures incidence rate, and Be very effective.
Six, safety evaluatio
After medication, patient's vital sign comprises blood pressure, heart rate, breathing, body temperature compared with before medication, has no significant change.In process of the test, there is not obvious exception or abnormal rise in test group routine blood test, liver function, renal function, electrocardiogram.
In sum:
The strong bone formula of bone pine effectively can improve the back or the aching and tired pain of whole body that patient causes by deficiency of the kidney yin blood stasis, limbs fatigue, and legs and feet knot, numb hand and foot, irritable, palpitation and insomnia, roars of laughter febrile perspiration goes out, red tongue, yellow fur, there is crackle, the symptoms such as thready and rapid pulse, reduce bone conversion, prevent bone density from declining, reduce fragility fractures incidence rate, evident in efficacy.
Claims (2)
1. a treatment osteoporotic bone pine bone invigorating composition, is characterized in that: described compositions is made up of crude drug Radix Rehmanniae Preparata 12-18 part, Fructus Corni 13-17 part, Radix Angelicae Sinensis 10-14 part, Herba Epimedii 14-16 part, Semen Cuscutae 10-14 part, Fructus Lycii 10-14 part, Rhizoma Atractylodis Macrocephalae 11-12 part and Pheretima 11-12 part according to parts by weight.
2. as claimed in claim 1 a kind of treat osteoporotic bone pine bone invigorating composition preparation technology, it is characterized in that: comprise the following steps:
Step one, get crude drug Radix Rehmanniae Preparata 12-18 part, Fructus Corni 13-17 part, Radix Angelicae Sinensis 10-14 part, Herba Epimedii 14-16 part, Semen Cuscutae 10-14 part, Fructus Lycii 10-14 part, Rhizoma Atractylodis Macrocephalae 11-12 part and Pheretima 11-12 part according to parts by weight, for subsequent use;
Step 2, get Herba Epimedii that step one obtains and Semen Cuscutae is placed in decocting device, the water adding Herba Epimedii and Semen Cuscutae gross weight 10 times again decocts, medicinal liquid is leached after decocting 2h, then in medicinal residues, the continuous water adding Herba Epimedii and Semen Cuscutae gross weight 8 times decocts 1.5h again, filters to obtain medicinal liquid, discards medicinal residues, merge twice medicinal liquid, being concentrated into relative density under medicinal liquid 80 DEG C of conditions is 1.03, obtains concentrated solution, for subsequent use;
Step 3, the Radix Rehmanniae Preparata that step one is obtained, Fructus Corni, Radix Angelicae Sinensis, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae and Pheretima, mixing is placed in super micron mill and pulverizes, and pulverizes after terminating and takes out 200 mesh sieves, obtain Chinese medicinal powder, for subsequent use;
The Chinese medicinal powder that step 4, the concentrated solution and the step 3 that step 2 are obtained obtain mixes, and then carries out preparation, i.e. the preparation of completed treatment osteoporotic bone pine bone invigorating composition.
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