CN103990099A - Traditional Chinese medicine composition for treating dysmenorrhea - Google Patents

Traditional Chinese medicine composition for treating dysmenorrhea Download PDF

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Publication number
CN103990099A
CN103990099A CN201410261256.8A CN201410261256A CN103990099A CN 103990099 A CN103990099 A CN 103990099A CN 201410261256 A CN201410261256 A CN 201410261256A CN 103990099 A CN103990099 A CN 103990099A
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China
Prior art keywords
chinese medicine
medicine composition
traditional chinese
dysmenorrhea
rhizoma
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Pending
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CN201410261256.8A
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Chinese (zh)
Inventor
李霞
姜国胜
王彬
姚成芳
王丽
郭钰琪
赖楠楠
彭莉
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INSTITUTE OF BASIC MEDICINE SAMS
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INSTITUTE OF BASIC MEDICINE SAMS
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Priority to CN201410261256.8A priority Critical patent/CN103990099A/en
Publication of CN103990099A publication Critical patent/CN103990099A/en
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Abstract

The invention provides a traditional Chinese medicine composition for treating dysmenorrheal. The traditional Chinese medicine composition is prepared from the following medicinal materials: 15g of angelica sinensis, 15g of ligusticum wallichii, 6g of cinnamon, 6g of baked ginger, 12g of fried cumin, 12g of raw pollen typhae, 12g of fried trogopterus dung, 12g of rhizoma corydalis, 12g of rhizoma cyperi, 18g of parched white peony root, 6g of liquorice, 12g of sinapis alba, 12g of fructus evodiae, 3g of panax notoginseng and 15g of astragalus membranaceus. The traditional Chinese medicine composition has a significant curative effect on dysmenorrhea.

Description

A kind of Chinese medicine composition for the treatment of dysmenorrhea
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of dysmenorrhea, belong to Chinese medicine technical field.
background technology
Dysmenorrhea (dysmenorrhea), means before and after menstrual period or between menstrual period, occurs hypogastric region spasmic pain, when serious, with nauseating, vomiting, cold extremities, very severe pain faintness, has a strong impact on daily life.Divide two kinds of constitutional and Secondary cases.Fail to find that through detailed gynecological clinic inspection pelvic organ has obviously abnormal person, claim primary dysmenorrhea, also claim primary dysmenorrhea.Secondary dysmenorrhea refers to that genitals has obvious pathological changes person, as endometriosis, and pelvic inflammatory disease, tumor etc.At present, the method for the treatment of dysmenorrhea is a lot, and western medicine dysmenorrhea adopts antipyretic analgesic and PGSI, contraceptive etc. more, and general analgesic effect is strong, but curative effect is of short duration, cannot effect a radical cure.Treatment by Chinese herbs method, conventional have TONGJING WAN, a YUANHU ZHITONG PIAN etc., and still, general cure rate is lower, is difficult to the effect that reaches satisfied.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of dysmenorrhea.
Technical scheme of the present invention is as follows:
A kind of Chinese medicine composition for the treatment of dysmenorrhea, be prepared from by following medical material: Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Cortex Cinnamomi 6g, Rhizoma Zingiberis Preparatum 6g, Fructus Foeniculi (parched) 12g, Pollen Tyjphae 12g, Oletum Trogopterori (parched) 12g, Rhizoma Corydalis 12g, Rhizoma Cyperi 12g, Radix Paeoniae Alba (parched) 18g, Radix Glycyrrhizae 6g, Semen Sinapis Albae 12g, Fructus Evodiae 12g, Radix Notoginseng 3g,, Radix Astragali 15g.
The present invention adopts following preparation method: take by weight above medical material, be soaked in the water of 8 times of volumes, medicine fully soaks 8 hours, and 120 DEG C of decoctions of the concentrated boiling machine of high pressure 90 minutes, leach medicinal liquid; Add 5 times of volume water, 120 DEG C of decoctions of the concentrated boiling machine of high pressure 90 minutes, leach medicinal liquid again; The medicinal liquid leaching for twice is merged, and heating is concentrated, and in concentrated solution, adding ethanol to concentration of alcohol is 60%, fully mixes, and precipitation is spent the night, leaching supernatant; In precipitation, adding ethanol to concentration of alcohol is 75%, fully mixes, and precipitation is spent the night, leaching supernatant; In precipitation, adding ethanol to concentration of alcohol is 85%, fully mixes, and precipitation is spent the night, leaching supernatant.The supernatant of three precipitate with ethanol leachings is mixed to final vacuum negative pressure heating recovery ethanol, and heating is concentrated, makes its concentration for containing crude drug 2.0~4.5 grams per milliliters.
Instructions of taking a: prescription is potion, and potion is taken one day.Three times on the one, one after each meal, in start to take through first three day at every turn, serve on within the 4th day, being a menstrual cycle through row, and 3 menstrual cycle are a course for the treatment of.
The present invention can add the adjuvant pharmaceutically allowing on the basis of concentrated extract, makes other dosage form, as multiple dosage forms such as pill, tablet, capsule, oral liquid, drop pill, sustained-release preparations.
Prescription of the present invention is scientific and reasonable, and crude drug source is extensively easy to get, and cost is low, safe without toxic side effect, and drug effect is fast, easy to use, and dysmenorrhea is had to significant curative effect.
Detailed description of the invention
   
embodiment 1
Take Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Cortex Cinnamomi 6g, Rhizoma Zingiberis Preparatum 6g, Fructus Foeniculi (parched) 12g, Pollen Tyjphae 12g, Oletum Trogopterori (parched) 12g, Rhizoma Corydalis 12g, Rhizoma Cyperi 12g, Radix Paeoniae Alba (parched) 18g, Radix Glycyrrhizae 6g, Semen Sinapis Albae 12g, Fructus Evodiae 12g, Radix Notoginseng 3g,, Radix Astragali 15g, be soaked in the water of 8 times of volumes, medicine fully soaks 8 hours, 120 DEG C of decoctions of the concentrated boiling machine of high pressure 90 minutes, leach medicinal liquid; Add 5 times of volume water, 120 DEG C of decoctions of the concentrated boiling machine of high pressure 90 minutes, leach medicinal liquid again; The medicinal liquid leaching for twice is merged, and heating is concentrated, and in concentrated solution, adding ethanol to concentration of alcohol is 60%, fully mixes, and precipitation is spent the night, leaching supernatant; In precipitation, adding ethanol to concentration of alcohol is 75%, fully mixes, and precipitation is spent the night, leaching supernatant; In precipitation, adding ethanol to concentration of alcohol is 85%, fully mixes, and precipitation is spent the night, leaching supernatant.The supernatant of three precipitate with ethanol leachings is mixed to final vacuum negative pressure heating recovery ethanol, and heating is concentrated, makes its concentration for containing crude drug 2.0~4.5 grams per milliliters.
clinical data
Efficacy assessment standard: the present invention is used for the treatment of dysmenorrhea disease, " traditional Chinese medical science disease Standardization of diagnosis and curative effect " that its criterion of therapeutical effect is issued with reference to State Administration of Traditional Chinese Medicine formulated, and is divided into following three kinds:
Cure: pain disappears, and recurrence is seen at continuous 3 menstrual cycle ends;
Take a turn for the better: pain relief or pain disappear, but can not maintain more than 3 months;
Do not heal: pain has no improvement.
Therapeutic effect: in the 192 routine cases of choosing at random, after the course for the treatment of, cure 114 examples, 72 examples that take a turn for the better, 6 examples that do not heal, total effective rate 96.9%, cure rate 59.4%, all cases all have no adverse reaction.Light moderate patient takes after 1 menstrual cycle, and Most patients disease disappears, and is cured, and small number of patients need be taken the just disease disappearance of 1 menstrual cycle again, is cured; Severe patient takes after 3 menstrual cycle, and some patients were disease disappears, and is cured, and most of patients is clearly better, and need take the just disease disappearance of 3 menstrual cycle again, is cured.
Model case
Case 1
Lee, female, 22 years old, student, when medical when patient's readme menstrual onset, lower abdomen pain, many through measuring, when heavy, with nausea and vomiting, accompany clot.Adopt Chinese medicine for oral administration of the present invention, premenstrual 3 days start to take, and serve on to through row the 4th day, and after the course for the treatment of, symptom obviously alleviates, and after three courses for the treatment of, dysmenorrhea symptom disappears completely, after 6 months, follows up a case by regular visits to, and has no recurrence.

Claims (1)

1. treat the Chinese medicine composition of dysmenorrhea for one kind, it is characterized in that, be prepared from by following medical material: Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Cortex Cinnamomi 6g, Rhizoma Zingiberis Preparatum 6g, Fructus Foeniculi (parched) 12g, Pollen Tyjphae 12g, Oletum Trogopterori (parched) 12g, Rhizoma Corydalis 12g, Rhizoma Cyperi 12g, Radix Paeoniae Alba (parched) 18g, Radix Glycyrrhizae 6g, Semen Sinapis Albae 12g, Fructus Evodiae 12g, Radix Notoginseng 3g,, Radix Astragali 15g.
CN201410261256.8A 2014-06-13 2014-06-13 Traditional Chinese medicine composition for treating dysmenorrhea Pending CN103990099A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104436064A (en) * 2014-12-17 2015-03-25 周连才 Pharmaceutical composition for treating dysmenorrhea
CN104888182A (en) * 2015-07-07 2015-09-09 韩军 Traditional Chinese medicine preparation for treating postpartum abdominal pain and preparation method therefor
CN105213999A (en) * 2015-11-09 2016-01-06 青岛安倍康生物医药技术有限公司 Radix Salviae Miltiorrhizae leaf health-care tea of a kind of antalgic and preparation method thereof
CN106421694A (en) * 2016-09-27 2017-02-22 辽宁中医药大学附属医院 Externally used Chinese herba preparation for treating dysmenorrhea
CN107137693A (en) * 2017-07-24 2017-09-08 甘肃瀛海堂医药有限公司 A kind of Chinese medicine composition for treating dysmenorrhoea

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1650980A (en) * 2004-11-30 2005-08-10 许跃华 Preparation of medicine using formula containing angelicae sinensis radix etc. for treating gynecopathy algomenorrhea
CN103585609A (en) * 2013-11-20 2014-02-19 潘恒晔 Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1650980A (en) * 2004-11-30 2005-08-10 许跃华 Preparation of medicine using formula containing angelicae sinensis radix etc. for treating gynecopathy algomenorrhea
CN103585609A (en) * 2013-11-20 2014-02-19 潘恒晔 Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof

Non-Patent Citations (2)

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Title
张丽娟: ""刘瑞芬治疗痛经经验"", 《山东中医杂志》, vol. 27, no. 10, 31 October 2008 (2008-10-31) *
王婷婷 等: ""痛经中医辨证治疗"", 《辽宁中医药大学学报》, vol. 15, no. 7, 31 July 2013 (2013-07-31) *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104436064A (en) * 2014-12-17 2015-03-25 周连才 Pharmaceutical composition for treating dysmenorrhea
CN104888182A (en) * 2015-07-07 2015-09-09 韩军 Traditional Chinese medicine preparation for treating postpartum abdominal pain and preparation method therefor
CN105213999A (en) * 2015-11-09 2016-01-06 青岛安倍康生物医药技术有限公司 Radix Salviae Miltiorrhizae leaf health-care tea of a kind of antalgic and preparation method thereof
CN106421694A (en) * 2016-09-27 2017-02-22 辽宁中医药大学附属医院 Externally used Chinese herba preparation for treating dysmenorrhea
CN106421694B (en) * 2016-09-27 2020-02-14 辽宁中医药大学附属医院 External traditional Chinese medicine preparation for treating dysmenorrhea
CN107137693A (en) * 2017-07-24 2017-09-08 甘肃瀛海堂医药有限公司 A kind of Chinese medicine composition for treating dysmenorrhoea

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Application publication date: 20140820