CN103990099A - Traditional Chinese medicine composition for treating dysmenorrhea - Google Patents
Traditional Chinese medicine composition for treating dysmenorrhea Download PDFInfo
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- CN103990099A CN103990099A CN201410261256.8A CN201410261256A CN103990099A CN 103990099 A CN103990099 A CN 103990099A CN 201410261256 A CN201410261256 A CN 201410261256A CN 103990099 A CN103990099 A CN 103990099A
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- chinese medicine
- medicine composition
- traditional chinese
- dysmenorrhea
- rhizoma
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- 239000003814 drug Substances 0.000 title claims abstract description 18
- 206010013935 Dysmenorrhoea Diseases 0.000 title claims abstract description 17
- 208000005171 Dysmenorrhea Diseases 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 title claims abstract description 9
- 241000218176 Corydalis Species 0.000 claims abstract description 4
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 4
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 4
- 239000009636 Huang Qi Substances 0.000 claims description 3
- 239000012567 medical material Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 6
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241001573366 Astragalus membranaceus Species 0.000 abstract 1
- 235000006463 Brassica alba Nutrition 0.000 abstract 1
- 244000140786 Brassica hirta Species 0.000 abstract 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 abstract 1
- 235000004310 Cinnamomum zeylanicum Nutrition 0.000 abstract 1
- 240000004559 Cuminum cyminum Species 0.000 abstract 1
- 235000007129 Cuminum cyminum Nutrition 0.000 abstract 1
- 210000003608 Feces Anatomy 0.000 abstract 1
- 240000005389 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 240000004600 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 241000301400 Trogopterus Species 0.000 abstract 1
- 240000007329 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 235000017803 cinnamon Nutrition 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 235000014063 licorice root Nutrition 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 26
- 238000001556 precipitation Methods 0.000 description 10
- 238000002386 leaching Methods 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000027758 ovulation cycle Effects 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 238000009835 boiling Methods 0.000 description 4
- 229940079593 drugs Drugs 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229940023488 Pill Drugs 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000003821 menstrual periods Effects 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001225 therapeutic Effects 0.000 description 2
- 210000001015 Abdomen Anatomy 0.000 description 1
- 208000002173 Dizziness Diseases 0.000 description 1
- 210000004392 Genitalia Anatomy 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010034568 Peripheral coldness Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000240 adjuvant Effects 0.000 description 1
- 230000000202 analgesic Effects 0.000 description 1
- 239000003907 antipyretic analgesic agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000002254 contraceptive Effects 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 201000009273 endometriosis Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000002175 menstrual Effects 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 201000006518 pelvic inflammatory disease Diseases 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 231100000224 toxic side effect Toxicity 0.000 description 1
- 239000008964 yuanhu zhitong Substances 0.000 description 1
Abstract
The invention provides a traditional Chinese medicine composition for treating dysmenorrheal. The traditional Chinese medicine composition is prepared from the following medicinal materials: 15g of angelica sinensis, 15g of ligusticum wallichii, 6g of cinnamon, 6g of baked ginger, 12g of fried cumin, 12g of raw pollen typhae, 12g of fried trogopterus dung, 12g of rhizoma corydalis, 12g of rhizoma cyperi, 18g of parched white peony root, 6g of liquorice, 12g of sinapis alba, 12g of fructus evodiae, 3g of panax notoginseng and 15g of astragalus membranaceus. The traditional Chinese medicine composition has a significant curative effect on dysmenorrhea.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of dysmenorrhea, belong to Chinese medicine technical field.
background technology
Dysmenorrhea (dysmenorrhea), means before and after menstrual period or between menstrual period, occurs hypogastric region spasmic pain, when serious, with nauseating, vomiting, cold extremities, very severe pain faintness, has a strong impact on daily life.Divide two kinds of constitutional and Secondary cases.Fail to find that through detailed gynecological clinic inspection pelvic organ has obviously abnormal person, claim primary dysmenorrhea, also claim primary dysmenorrhea.Secondary dysmenorrhea refers to that genitals has obvious pathological changes person, as endometriosis, and pelvic inflammatory disease, tumor etc.At present, the method for the treatment of dysmenorrhea is a lot, and western medicine dysmenorrhea adopts antipyretic analgesic and PGSI, contraceptive etc. more, and general analgesic effect is strong, but curative effect is of short duration, cannot effect a radical cure.Treatment by Chinese herbs method, conventional have TONGJING WAN, a YUANHU ZHITONG PIAN etc., and still, general cure rate is lower, is difficult to the effect that reaches satisfied.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of dysmenorrhea.
Technical scheme of the present invention is as follows:
A kind of Chinese medicine composition for the treatment of dysmenorrhea, be prepared from by following medical material: Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Cortex Cinnamomi 6g, Rhizoma Zingiberis Preparatum 6g, Fructus Foeniculi (parched) 12g, Pollen Tyjphae 12g, Oletum Trogopterori (parched) 12g, Rhizoma Corydalis 12g, Rhizoma Cyperi 12g, Radix Paeoniae Alba (parched) 18g, Radix Glycyrrhizae 6g, Semen Sinapis Albae 12g, Fructus Evodiae 12g, Radix Notoginseng 3g,, Radix Astragali 15g.
The present invention adopts following preparation method: take by weight above medical material, be soaked in the water of 8 times of volumes, medicine fully soaks 8 hours, and 120 DEG C of decoctions of the concentrated boiling machine of high pressure 90 minutes, leach medicinal liquid; Add 5 times of volume water, 120 DEG C of decoctions of the concentrated boiling machine of high pressure 90 minutes, leach medicinal liquid again; The medicinal liquid leaching for twice is merged, and heating is concentrated, and in concentrated solution, adding ethanol to concentration of alcohol is 60%, fully mixes, and precipitation is spent the night, leaching supernatant; In precipitation, adding ethanol to concentration of alcohol is 75%, fully mixes, and precipitation is spent the night, leaching supernatant; In precipitation, adding ethanol to concentration of alcohol is 85%, fully mixes, and precipitation is spent the night, leaching supernatant.The supernatant of three precipitate with ethanol leachings is mixed to final vacuum negative pressure heating recovery ethanol, and heating is concentrated, makes its concentration for containing crude drug 2.0～4.5 grams per milliliters.
Instructions of taking a: prescription is potion, and potion is taken one day.Three times on the one, one after each meal, in start to take through first three day at every turn, serve on within the 4th day, being a menstrual cycle through row, and 3 menstrual cycle are a course for the treatment of.
The present invention can add the adjuvant pharmaceutically allowing on the basis of concentrated extract, makes other dosage form, as multiple dosage forms such as pill, tablet, capsule, oral liquid, drop pill, sustained-release preparations.
Prescription of the present invention is scientific and reasonable, and crude drug source is extensively easy to get, and cost is low, safe without toxic side effect, and drug effect is fast, easy to use, and dysmenorrhea is had to significant curative effect.
Detailed description of the invention
embodiment 1
Take Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Cortex Cinnamomi 6g, Rhizoma Zingiberis Preparatum 6g, Fructus Foeniculi (parched) 12g, Pollen Tyjphae 12g, Oletum Trogopterori (parched) 12g, Rhizoma Corydalis 12g, Rhizoma Cyperi 12g, Radix Paeoniae Alba (parched) 18g, Radix Glycyrrhizae 6g, Semen Sinapis Albae 12g, Fructus Evodiae 12g, Radix Notoginseng 3g,, Radix Astragali 15g, be soaked in the water of 8 times of volumes, medicine fully soaks 8 hours, 120 DEG C of decoctions of the concentrated boiling machine of high pressure 90 minutes, leach medicinal liquid; Add 5 times of volume water, 120 DEG C of decoctions of the concentrated boiling machine of high pressure 90 minutes, leach medicinal liquid again; The medicinal liquid leaching for twice is merged, and heating is concentrated, and in concentrated solution, adding ethanol to concentration of alcohol is 60%, fully mixes, and precipitation is spent the night, leaching supernatant; In precipitation, adding ethanol to concentration of alcohol is 75%, fully mixes, and precipitation is spent the night, leaching supernatant; In precipitation, adding ethanol to concentration of alcohol is 85%, fully mixes, and precipitation is spent the night, leaching supernatant.The supernatant of three precipitate with ethanol leachings is mixed to final vacuum negative pressure heating recovery ethanol, and heating is concentrated, makes its concentration for containing crude drug 2.0～4.5 grams per milliliters.
clinical data
Efficacy assessment standard: the present invention is used for the treatment of dysmenorrhea disease, " traditional Chinese medical science disease Standardization of diagnosis and curative effect " that its criterion of therapeutical effect is issued with reference to State Administration of Traditional Chinese Medicine formulated, and is divided into following three kinds:
Cure: pain disappears, and recurrence is seen at continuous 3 menstrual cycle ends;
Take a turn for the better: pain relief or pain disappear, but can not maintain more than 3 months;
Do not heal: pain has no improvement.
Therapeutic effect: in the 192 routine cases of choosing at random, after the course for the treatment of, cure 114 examples, 72 examples that take a turn for the better, 6 examples that do not heal, total effective rate 96.9%, cure rate 59.4%, all cases all have no adverse reaction.Light moderate patient takes after 1 menstrual cycle, and Most patients disease disappears, and is cured, and small number of patients need be taken the just disease disappearance of 1 menstrual cycle again, is cured; Severe patient takes after 3 menstrual cycle, and some patients were disease disappears, and is cured, and most of patients is clearly better, and need take the just disease disappearance of 3 menstrual cycle again, is cured.
Model case
Case 1
Lee, female, 22 years old, student, when medical when patient's readme menstrual onset, lower abdomen pain, many through measuring, when heavy, with nausea and vomiting, accompany clot.Adopt Chinese medicine for oral administration of the present invention, premenstrual 3 days start to take, and serve on to through row the 4th day, and after the course for the treatment of, symptom obviously alleviates, and after three courses for the treatment of, dysmenorrhea symptom disappears completely, after 6 months, follows up a case by regular visits to, and has no recurrence.
Claims (1)
1. treat the Chinese medicine composition of dysmenorrhea for one kind, it is characterized in that, be prepared from by following medical material: Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 15g, Cortex Cinnamomi 6g, Rhizoma Zingiberis Preparatum 6g, Fructus Foeniculi (parched) 12g, Pollen Tyjphae 12g, Oletum Trogopterori (parched) 12g, Rhizoma Corydalis 12g, Rhizoma Cyperi 12g, Radix Paeoniae Alba (parched) 18g, Radix Glycyrrhizae 6g, Semen Sinapis Albae 12g, Fructus Evodiae 12g, Radix Notoginseng 3g,, Radix Astragali 15g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410261256.8A CN103990099A (en) | 2014-06-13 | 2014-06-13 | Traditional Chinese medicine composition for treating dysmenorrhea |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410261256.8A CN103990099A (en) | 2014-06-13 | 2014-06-13 | Traditional Chinese medicine composition for treating dysmenorrhea |
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| Publication Number | Publication Date |
|---|---|
| CN103990099A true CN103990099A (en) | 2014-08-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410261256.8A Pending CN103990099A (en) | 2014-06-13 | 2014-06-13 | Traditional Chinese medicine composition for treating dysmenorrhea |
Country Status (1)
| Country | Link |
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| CN (1) | CN103990099A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436064A (en) * | 2014-12-17 | 2015-03-25 | 周连才 | Pharmaceutical composition for treating dysmenorrhea |
| CN104888182A (en) * | 2015-07-07 | 2015-09-09 | 韩军 | Traditional Chinese medicine preparation for treating postpartum abdominal pain and preparation method therefor |
| CN105213999A (en) * | 2015-11-09 | 2016-01-06 | 青岛安倍康生物医药技术有限公司 | Radix Salviae Miltiorrhizae leaf health-care tea of a kind of antalgic and preparation method thereof |
| CN106421694A (en) * | 2016-09-27 | 2017-02-22 | 辽宁中医药大学附属医院 | Externally used Chinese herba preparation for treating dysmenorrhea |
| CN107137693A (en) * | 2017-07-24 | 2017-09-08 | 甘肃瀛海堂医药有限公司 | A kind of Chinese medicine composition for treating dysmenorrhoea |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1650980A (en) * | 2004-11-30 | 2005-08-10 | 许跃华 | Preparation of medicine using formula containing angelicae sinensis radix etc. for treating gynecopathy algomenorrhea |
| CN103585609A (en) * | 2013-11-20 | 2014-02-19 | 潘恒晔 | Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof |
-
2014
- 2014-06-13 CN CN201410261256.8A patent/CN103990099A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1650980A (en) * | 2004-11-30 | 2005-08-10 | 许跃华 | Preparation of medicine using formula containing angelicae sinensis radix etc. for treating gynecopathy algomenorrhea |
| CN103585609A (en) * | 2013-11-20 | 2014-02-19 | 潘恒晔 | Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 张丽娟: ""刘瑞芬治疗痛经经验"", 《山东中医杂志》, vol. 27, no. 10, 31 October 2008 (2008-10-31) * |
| 王婷婷 等: ""痛经中医辨证治疗"", 《辽宁中医药大学学报》, vol. 15, no. 7, 31 July 2013 (2013-07-31) * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104436064A (en) * | 2014-12-17 | 2015-03-25 | 周连才 | Pharmaceutical composition for treating dysmenorrhea |
| CN104888182A (en) * | 2015-07-07 | 2015-09-09 | 韩军 | Traditional Chinese medicine preparation for treating postpartum abdominal pain and preparation method therefor |
| CN105213999A (en) * | 2015-11-09 | 2016-01-06 | 青岛安倍康生物医药技术有限公司 | Radix Salviae Miltiorrhizae leaf health-care tea of a kind of antalgic and preparation method thereof |
| CN106421694A (en) * | 2016-09-27 | 2017-02-22 | 辽宁中医药大学附属医院 | Externally used Chinese herba preparation for treating dysmenorrhea |
| CN106421694B (en) * | 2016-09-27 | 2020-02-14 | 辽宁中医药大学附属医院 | External traditional Chinese medicine preparation for treating dysmenorrhea |
| CN107137693A (en) * | 2017-07-24 | 2017-09-08 | 甘肃瀛海堂医药有限公司 | A kind of Chinese medicine composition for treating dysmenorrhoea |
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| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140820 |