CN106237128A

CN106237128A - The Semen Cuscutae oral liquor of slow down aging and oral liquid thereof

Info

Publication number: CN106237128A
Application number: CN201610626423.3A
Authority: CN
Inventors: 马佳
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-08-02
Filing date: 2016-08-02
Publication date: 2016-12-21

Abstract

The invention discloses the preparation method of the Semen Cuscutae oral liquid of a kind of slow down aging, including following aspect: the screening of a. Semen Cuscutae, dry in the sun；B. the Semen Cuscutae dried well is steeped and extract into ethanol, become component 1；C. other raw material soaking ethanol heating extraction described are become extractum, for component 2；The most again above two component is merged, be condensed into after pasty state adds Mel or dextrin mediation canned.In described step a, ripe Semen Cuscutae fruit of gathering in 9～October, together cut off with host, dry, lay seed, decontamination of winnowing with a dustpan, clean, dry.In the present invention, Semen Cuscutae acrid-sweet flavor, there is the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive effect.Can be used for the diseases such as soreness of waist and knee joint, sexual impotence, premature ejaculation, the enuresis, the frequent micturition heeltap, tinnitus, dizziness dim eyesight, visual deterioration.Blood circulation promoting and blood stasis dispelling of the present invention, warming and recuperating the kidney-YANG, can preferably reach effect of slow down aging.

Description

The Semen Cuscutae oral liquor of slow down aging and oral liquid thereof

Technical field

The present invention relates to containing the health product deriving from plant composition, the Semen Cuscutae particularly to a kind of slow down aging is administered orally Liquid and preparation method thereof.

Background technology

Investigating according to bioscience man, the number of times of biological cell division was directly proportional to the life-span, and such as, the cell of dolphin divides Splitting number of times is 80 times, and its average life is then up to 150 years old.And the reason of the human senility composition that human body life is most basic just Unit--cell occurs in that decay.Along with the increase at age, the division of cell regeneration is increasingly slower, and the aged cells of accumulation makes device The function of official constantly declines, and aging even pathological changes occurs, and people is the oldest and the most feeble.

Modern science is thought: aging is the irresistible natural law, and the aging of people and death are absolute.But, logical Cross scientific method, the aging of people can be delayed completely, postpone the time of birth and old age, sickness and death and improve the quality of life of human body.Allow people The mental status kept in the sufficiently long time and beautiful appearance, allow the mankind's maximum length under existing conditions of existence In the longevity, these are strictly what we can accomplish.Modern life scientist is in long-term research human aging process, it is proposed that Various " old and feeble theoretical " and " aging model theory ".

People in middle age, physical function started progressively old and feeble, and libido declines, and man, to the middle age, should bear family and society The important task of meeting, the most also will be in the face of the various change such as working condition, physical function, the most only in dietary habit, life style Carrying out necessary adjustment with mental status aspect, physical condition could be full of energy ground and adapt to the needs of new change.Traditional Chinese doctors ' Learn the research to life lengthening, have long history, precious document to record and abundant practical experience.Shennong's Herbal Describe relevant antiaging agent, be the most valuable document of antiaging agent.The Han Wei Six Dynasties is to the Tang Dynasty, the medicine of defying age Research, comes into one's own further, and big physician's Sun Simiao emphasizes that defying age also should be made for slow down aging based on reinforcement, dietetic therapy Having gone out the contribution of preciousness, until the Ming Dynasty, great medical scholar's Li Shizhen (1518-1593 A.D.) is traditional antiaging agent before summarizing bright Wanli year Experience, his written Compendium of Material Medica has been collected medication of prolonging life 253 kinds, has also been collected life lengthening side 89 first.Wherein have A little prescriptions are the most still used as aged healthcare products, and meanwhile, he also praises highly antiaging agent and also dialectical should use and advocate with nontoxic Animal and plant medicine, the experience of ancients is the data that modern research on anti-senescence provides preciousness.After founding of New, especially from 20th century Since the seventies, China's geriatrics emerges, along with the traditional Chinese medical science, the combination of Chinese and Western medicine progressively going deep into Gerontological Research Center, anti-ageing The research of old medicine is increasingly subject to pay attention to, and various places medical personal is in the ascendant to the research of defying age compound medicine.Currently, I State will step into aging society, furthers investigate anti-aging compound recipe medicine, will be conducive to China's " healthy aging " target Realization.

Modern medicine study shows, old and feeble essence is the decline of stem cell, the decline of immunity, tissue organ function Degeneration, the decline of defying age gene；Therefore, scientist thinks the immunity of human body to be improved, and the most basic way is to delay people The aging course of body.It is alive for evermore to pursue, and delays life, is mankind's dreams for thousands of years, and human sciences family is the most long-term and unremitting Ground research is about the problem of Human Longevity.Along with the development of modern genetic technology, scientist has opened the mystery of mankind aging seemingly, All antiaging agents emerge in an endless stream of all shapes and colors, and its effect has some idea of.Though it can not allow the mankind alive for evermore, people can be made Good health and a long life, allow mythology come true the most at last.It is true that along with the development of mankind's defying age medical science, scientists has been taken off Illustrating such a new idea: the aging of the mankind is the most irresistible, the aging of human body itself is a kind of disease.And then section Scholar also have found prevention and the medicine for the treatment of mankind aging.Clinical practice also indicates that, by treatment, the aging course of human body is not Only can delay and can reverse.Cell is to meaning that life from the point of view of people, and the birth and old age, sickness and death of cell are also human body degradations One process.The growth of cell leans on to be division, slows down the minimizing that just imply that regenerative cell once the split speed of cell, that It is exactly everybody old and feeble beginning of fearing, so prevent aging the most finally sums up in the point that cell.Today, people utilize sheep embryo Competent cell in tire element helps aging cellular-restoring activity, accelerates the division of human body cell, so that regenerative cell number Increase.

Semen Cuscutae is listed in top grade in Shennong's Herbal.Its abnormal smells from the patient is pungent, sweet, flat nontoxic.Function with cure mainly: the kidney invigorating benefit Essence, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, The diseases such as dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.Generally arranged Can take for a long time for top grade, take improving eyesight for a long time and make light of one's life by commiting suicide and prolong life.But yang deficiency hyperactivity of fire, postcoital protrusion not flaccidity and constipation due to dry stool person prohibit clothes, according to individual People's body constitution, if there is sign of getting angry, just cuts out.It can cause sexual function hyperfunction.

" herbal classic is met former ": " Liver and kidney edema caused by disorder of QI is also for Semen Cuscutae, dispelling pathogenic wind for improving eyesight.Its property and flavor of peppery and warm matter is glued, and warms up with the strong muscle of the Cortex Eucommiae Waist knee joint is as good as.Its merit is specially in benefit marrow, and hard muscles and bones, only spermatorrhea, stem essence of trembling with fear goes out, and drowns and has the heeltap, goes knee joint soreness of the shank soft, old man's Liver and kidney The deficiency of vital energy, lumbago knee joint is cold, close Fructus Psoraleae, the Cortex Eucommiae with it, all fascias come under liver also.Deficiency of vital energy gb 1, without god person, helps it with Radix Ophiopogonis, Honeyed pill takes, effect.All postcoital protrusion not flaccidity, constipation due to dry stool, little water red puckery person not use, the most supporing yang also with its property.″

Modern selects some health foods or functional food to be provided to building body.The function of health product mainly changes Kind blood circulation of human body, improves body immunity, slow down aging.Chinese medicine also exists dual regulation, and central concentration is too high Time, certain antagonism may be caused, and make drug effect impacted；During low dosage, possible drug level is too low, causes drug effect and does not shows. And for the traditional Chinese medical science, whether the formula components various aspects from traditional Chinese medical science mechanism, dosage form or the medicine of institute's foundation all do not have Bigger breakthrough, takes mouthfeel the best, and medicine is poor, takes very inconvenient, it is impossible to meet the demand of various patient, the most not The city life of modern high rhythm can be met.The insufficiency of kidney-YANG state generally existed in the face of more and more urbanites, Chinese Herbs is slow, Taking trouble, should not improve the traditional therapy of long-term taking, effect is the most preferable, extensively will not be connect by masses It is subject to.How the efficacy exertion of Semen Cuscutae to maximum is not the most injured human body, and be obviously improved mouthfeel, enable a person to accept, be me Problem in the urgent need to address.Containing a large amount of safely and effectively active substance health product inside Semen Cuscutae, people can be greatly improved Body immunity, always people expect the key of solution problem.

Summary of the invention

The technical problem to be solved is, the various health product sold the most on the market, dragons and fishes jumbled together for medicine, The amusement of great majority simply false propaganda, have does not only have health-care components, also results in the huge injury of the person.Chinese medicine odor Poverty, a lot of people are reluctant long-term taking；Even if taking, be three points of poison of medicine, allow people's long-term taking time also produce resisting psychology.Herba cuscutae Sub-acrid-sweet flavor, property is put down, is entered liver, kidney two warp.There is the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive effect.Can be used for soreness of waist and knee joint, sun Flaccidity, premature ejaculation, seminal emission, the enuresis, the frequent micturition heeltap, tinnitus, dizziness dim eyesight, visual deterioration, threatened abortion, the inferior disease of band.Add one A little blood circulation promoting and blood stasis dispelling, the light Chinese medicine of mouthfeel, do not affect mouthfeel, make people be prone to accept, can preferably reach effect of slow down aging.This Inventing technical problem to be solved to be, Chinese medicine odor is poor, and mouthfeel is the best；A lot of people are reluctant to take；When allowing people use also Produce resisting psychology.In view of the traditional Chinese medical science has the characteristic of dialectical treatmert, the advantage that Chinese medicine toxic side effect is little, Chinese medicine health-care treatment is drawn Play extensive concern.

For solving above-mentioned technical barrier, the present invention provides the Semen Cuscutae oral liquid of a kind of slow down aging, its described Semen Cuscutae Oral liquid can include the crude drug of following weight portion: Semen Cuscutae 10～50 parts, Herb Gynostemmae Pentaphylli 10～20 parts, Herba Artemisiae Scopariae 10～20 Part, Rhizoma Polygonati 10～20 parts, Fructus Corni 10～20 parts, Radix Notoginseng 10～20 parts, Herba Rabdosiae Lophanthoidis 10～20 parts, Radix Codonopsis 10～20 parts, Fructus Lycii 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, the Rhizoma Atractylodis Macrocephalae 10～20 parts, Fructus Schisandrae Chinensis 10～20 parts, Fructus Ligustri Lucidi 10～20 Part, Radix Polygalae 10～20 parts, Radix Rhodiolae 10～20 parts, Radix Trichosanthis 10～20 parts, Radix Paeoniae Rubra 10～20 parts, Rhizoma Curculiginis 10～20 parts, Semen Maydis Must 10～20 parts, Semen Platycladi 10～20 parts, Semen Plantaginis 10～20 parts, Radix Bupleuri 10～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Spica Prunellae 10～ 20 parts.

The Semen Cuscutae oral liquid of described slow down aging, can also include following weight portion in its described Semen Cuscutae oral liquid Crude drug: Semen Cuscutae 10～30 parts, Herb Gynostemmae Pentaphylli 10～15 parts, Herba Artemisiae Scopariae 10～15 parts, Rhizoma Polygonati 10～15 parts, Fructus Corni 10～15 Part, Radix Notoginseng 10～15 parts, Herba Rabdosiae Lophanthoidis 10～15 parts, Radix Codonopsis 10～15 parts, Fructus Lycii 10～15 parts, Radix Polygoni Multiflori Preparata 10～15 parts, Radix Rehmanniae Preparata 10～15 parts, the Rhizoma Atractylodis Macrocephalae 10～15 parts, Fructus Schisandrae Chinensis 10～15 parts, Fructus Ligustri Lucidi 10～15 parts, Radix Polygalae 10～20 parts, Radix Rhodiolae 10～20 Part, Radix Trichosanthis 10～20 parts, Radix Paeoniae Rubra 10～20 parts, Rhizoma Curculiginis 10～20 parts, Stigma Maydis 10～20 parts, Semen Platycladi 10～20 parts, car First sub 10～20 parts, Radix Bupleuri 10～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Spica Prunellae 10～20 parts.

The Semen Cuscutae oral liquid of described slow down aging, can also include following weight portion in its described Semen Cuscutae oral liquid Crude drug: Semen Cuscutae 10～40 parts, Herb Gynostemmae Pentaphylli 10～20 parts, Herba Artemisiae Scopariae 10～20 parts, Rhizoma Polygonati 10～20 parts, Fructus Corni 10～20 Part, Radix Notoginseng 10～20 parts, Herba Rabdosiae Lophanthoidis 10～20 parts, Radix Codonopsis 10～20 parts, Fructus Lycii 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, the Rhizoma Atractylodis Macrocephalae 10～20 parts, Fructus Schisandrae Chinensis 10～20 parts, Fructus Ligustri Lucidi 10～20 parts, Radix Polygalae 10～15 parts, Radix Rhodiolae 10～15 Part, Radix Trichosanthis 10～15 parts, Radix Paeoniae Rubra 10～15 parts, Rhizoma Curculiginis 10～15 parts, Stigma Maydis 10～15 parts, Semen Platycladi 10～15 parts, car First sub 10～15 parts, Radix Bupleuri 10～15 parts, the Rhizoma Anemarrhenae 10～15 parts, Spica Prunellae 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for the preparation method of the Semen Cuscutae oral liquid of a kind of slow down aging, The preparation process of its described Semen Cuscutae oral liquid includes following aspect:

A. the screening of Semen Cuscutae, dry in the sun；

B. the Semen Cuscutae dried well is steeped and extract into ethanol, become component 1；

C. other raw material soaking ethanol heating extraction described are become extractum, for component 2；

The most again above two component is merged, be condensed into after pasty state adds Mel or dextrin mediation canned.

In described step a, ripe Semen Cuscutae fruit of can gathering in 9～October, together cut off with host, dry, lay Seed, decontamination of winnowing with a dustpan, clean, dry.

In described step b, the Semen Cuscutae that dry in the sun is good can be soaked and be placed in lid stainless steel cask, be added 70% ethanol Liquid, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；At the bottom of percolator Drug sample after moistening expansion is mixed pine after paving and is done to dissipate by portion's filter plate gauze bag parcel again, then contains powder with rustless steel spoon, Load percolator uniformly, fill 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, and loading in layer, suitably add Pressure, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens below percolator Baiting valve, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol stream Go out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed Generally 1000g medical material outflow per minute 2～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into reservoir Cylinder；Being merged by percolate and stand, stand for standby use, as component 1.

In described step c, can take in the ethanol that other starting material left raw materials steep 5-10 times amount, soak 24 hours, add Heat extraction 2 times, each 1-2 hour, united extraction liquid, take supernatant after standing, be then placed in concentrating under reduced pressure tank, recovered under reduced pressure Ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, and when the relative density of sucking filtration to filtrate is 20 DEG C, the extractum of 1.06, becomes Component 2.

In described step d, the extractum that above-mentioned steps obtains can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C Relative density is the concentrated solution of 1.05, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr that cold preservation liquid is added 0.3%, Filtering, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml crude drug amount Han 0.1g；Unguentum after concentration adds Mel and adjusts With make oral liquid.

For solving above-mentioned technical problem, the present invention also provides for the preparation method of the Semen Cuscutae oral liquid of a kind of slow down aging, Its preparation process can also be:

A. the preparation of Semen Cuscutae, as component 1；

B. remaining crude drug described chopping is extracted as component 2；

C. component 1 and component 2 are mixed, add proper honey after concentration and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step b, can be mixed by remaining raw medicinal material, shred 100～120 mesh sieves, after sieving, fine powder is standby, Coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, impregnates 15～30 days together with more than 70 degree ethanol, is then heated to reflux carrying Take 2 times, each 1～2 hour, 2 extracting solution are merged and stands, filter, after separation, take filtrate；By filtered through gauze, residue adds Entering 50-60% ethanol, 60 DEG C-70 DEG C are continued extraction 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, is condensed into Pasty state becomes component 2.

Useful the having technical effect that of the present invention, Semen Cuscutae is listed in top grade in Shennong's Herbal.Its abnormal smells from the patient is pungent, Sweet, flat nontoxic.Function with cure mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, and legs and feet are weak Unable, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, The diseases such as habitual abortion；Adding some blood circulation promoting and blood stasis dispelling, the Chinese crude drug of invigorating spleen to remove dampness yin nourishing, the most mouthfeel of these medical materials is light, Do not affect the taste of Semen Cuscutae tea, there is no the unpleasant taste of Chinese medicine being difficult to and swallowing, make people be prone to accept, can obvious slow down aging, Can preferably improve sub-health population easy catching a cold, eyes are sour and astringent, sleep quality is the highest, insufficiency of the spleen weak；Lack of appetite xerostomia；Quench one's thirst；Kidney Lose soreness of the waist and knees；Impotence and seminal emission；Tinnitus mesh is dark；Early whitening of beard and hair；Body void is won thin；The symptom of wind favus disease, can preferably reach to prolong Slow old and feeble effect.

Detailed description of the invention

People in middle age, physical function started progressively old and feeble, and this is the irreversible natural law.Go out and appear tired asthenia, libido Decline, especially precipitate psychosocial burden.Man, to the middle age, should bear family and the important task of society, the most also will be in the face of work Make the various change such as condition, physical function, in terms of dietary habit, life style and mental status, the most only carry out necessary tune Whole, physical condition could be full of energy ground and adapt to the needs of new change.Investigate according to bioscience man, the number of times of biological cell division Being directly proportional to the life-span, such as, the frequency dividing cell of dolphin is 80 times, and its average life is then up to 150 years old.And human body Old and feeble reason human body life just most basic composition unit--cell occurs in that decay.Along with the increase at age, cell is again Raw division is increasingly slower, and the aged cells of accumulation makes the function of organ constantly decline, and aging even pathological changes occurs, and people is the most therewith Day by day old and feeble.

The Chinese medicine research to life lengthening, has long history, precious document to record and abundant reality Trample experience.Shennong's Herbal describes relevant antiaging agent, is the most valuable document of antiaging agent.The Han Wei Six Dynasties To the Tang Dynasty, the medical research of defying age, coming into one's own further, big physician's Sun Simiao emphasizes that defying age should be with reinforcement, dietetic therapy Be main, also made the contribution of preciousness for slow down aging, until the Ming Dynasty, great medical scholar's Li Shizhen (1518-1593 A.D.) summarize bright Wanli year with The experience of front tradition antiaging agent, his written Compendium of Material Medica has been collected medication of prolonging life 253 kinds, has also been collected and prolonged life The side of lengthening one's life 89 is first.Some of which prescription is the most still used as aged healthcare products, and meanwhile, he also praises highly antiaging agent also should be dialectical Using and advocate and use nontoxic animal and plant medicine, the experience of ancients is the data that modern research on anti-senescence provides preciousness.New China becomes After Li, especially since 20 century 70s, China's geriatrics emerges, along with geriatrics is ground by the traditional Chinese medical science, the combination of Chinese and Western medicine That studies carefully progressively gos deep into, and the research of antiaging agent is increasingly subject to pay attention to, and defying age compound medicine is ground by various places medical personal Study carefully in the ascendant.Currently, China will step into aging society, furthers investigate anti-aging compound recipe medicine, will be conducive to China The realization of " healthy aging " target.

" Semen Cuscutae ", has another name called SEMEN CUSCUTAE, Herba cuscutae real, without ma rattan, dodder laurel, Tu rattan, Tu thread, wild Vulpes silk, bean parasitism, Caulis Fibraureae Son, trailing plants SIZI etc., for the seed of convolvulus cuscuta plant.There is the merit of " continuous wound absolutely, tonifying for the deficiency, the strong people of benefit "." Mingyi Bielu " The effect that calling it has " supporting flesh reinforcing YIN-essence, hard muscles and bones ".Motherland's medical science is thought, Semen Cuscutae acrid-sweet flavor, and property is put down, and enters liver, kidney two warp.Have The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive effect.Can be used for soreness of waist and knee joint, sexual impotence, premature ejaculation, seminal emission, the enuresis, the frequent micturition heeltap, ear Ring, dizziness dim eyesight, visual deterioration, threatened abortion, the inferior disease of band..

" book on Chinese herbal medicine converges and says ": " warming the spleen helps the medicine of stomach also for Semen Cuscutae, tonifying kidney and nourishing liver.But mend and the highest, temperature and the driest, therefore enter kidney Warp, void can mend, in fact can be in order to, cold can temperature, heat can be cool, wet can be dry, dry can moisten.If non-Cortex Phellodendri, the Rhizoma Anemarrhenae, bitter cold and The warmest, there is the gas rushing down kidney channel；If non-Cortex Cinnamomi, Fructus Alpiniae Oxyphyllae, hot and the coolest, there is the dry of kidney channel；If non-Herba Cistanches, trivial sun, Gan Xianer Stagnant gas, has wet person's ratio of raw kidney channel also.Hinder absolutely as " legendary god of farming's book on Chinese herbal medicine " is referred to as continuing, physical strength profiting, improving eyesight essence, all by tonifying kidney and nourishing liver, temperature Levying of taste of reason is tested also.″

" book on Chinese herbal medicine is newly organized ": " Semen Cuscutae, can reuse, also can be the most special.The people that chance is had a guilty conscience, day and night dream, the essence frequency person of letting out, With Semen Cuscutae three liang, ten bowls of water, liquor three bowls, point three clothes, early, noon, each clothes in evening i.e. stop.And lose the most again.This be the heart, liver, Kidney three is through neat sick, and extreme misery two is empty caused.The positive reinforcing the heart of Semen Cuscutae, liver, the panacea of kidney, the other taste that condition is the most miscellaneous, then power is especially special, so Can directly enter three through to receive effect also.He is as uneasy in night dream, and two blurred visions are dark, and biped is weak, one of all can use, two liang, same to Radix Ginseng, ripe Ground, the Rhizoma Atractylodis Macrocephalae, mountain sprout etc, with more than make outstanding contributions.″

" book on Chinese herbal medicine justice ": " Herba cuscutae is that yin nourishing dredging collateral is top grade.Its taste is micro-pungent, then have sun in the moon, keep and can walk, and grows with other The relatively greasy stagnant person of cloudy all medicines is the most different.Among Miao's secondary alcohol meaning five tastes, pungent logical four gas, " warp " Yan Xin is to moisten it, and the genus of Semen Cuscutae is Also, scorching with pungent perfume (or spice) is pungent, and widely different different, institute's solution is the most true and pertinent." herbal classic " continuous wound absolutely, tonifying for the deficiency, physical strength profiting, fertile strong people, in Among nourishing, all there are logical hundred arteries and veins of a surname, the meaning of Wen Yunyang sum.Juice goes to face, the function of the most soft and moist skin.Clothes then cloudy liquid mesh enough for a long time Self-evident." not Lu " so-called strong flesh of yin nourishing, hard muscles and bones, the also justice of negative and positive two tune.The cold essence of stem is sliding, then Yuanyang is uncomfortable and Zhiyin is not taken the photograph Also, drown have the heeltap, then kidney yang not cloth and air is not lifted yet.Dry yearningly with regard to bitter taste, bright drying up for cloudy liquid, cold blood becomes long-pending, is also Not declaring of yang-energy, only this kind YIN nourishing liquid and compress sun and, circulate hundred arteries and veins, so controlling it.With regarding Radix Rehmanniae generation specially in nourishing YIN, keep And do not walk person, intrinsic.″

Herba Rabdosiae Lophanthoidis, Classification system Rabdosia serra (Maxim.) Hara, Herba Rabdosiae Lophanthoidis is traditional herbal medicine, is commonly called as Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) Deng, there is clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, effect of cool the blood dissipate blood stasis, be used for treating acute icterohepatitis, acute cholecystitis, dysentery The diseases such as disease, enteritis, traumatic injury stasis of blood pain.Herba Rabdosiae Lophanthoidis has clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, effect of cool the blood dissipate blood stasis, is used for treating urgency Property icterohepatitis, acute cholecystitis, dysentery, enteritis, the difficulty in urination, the disease such as traumatic injury stasis of blood pain.Herba Rabdosiae Lophanthoidis is can not to treat slowly in fact Property hepatitis, if the icteric hepatitis B of samples can do acute treatment with Herba Rabdosiae Lophanthoidis, be that chronic viral hepatitis B is also intended to Do to regular hospital and treat targetedly, the most likely delay treatment, and then increase the difficulty cured.Chinese herbal medicine small stream is yellow Grass has certain effect to hepatitis, but, treatment small three positive effect is the most very limited.

Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and for clearing away heat-fire class medicine, its concrete effect is clear Diarrhea of heat type fire, promoting the production of body fluid to quench thirst, evacuation of pus is subsided a swelling.Cure mainly: control that calentura is thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For controlling Treat diabetes, conventional it with drugs for nourishing yin with the use of, to reach the effect for the treatment of both the principal and secondary aspects of a disease." book on Chinese herbal medicine converges and says ": Radix Trichosanthis, moves back the five internal organs Hot and suffocating, as heart-fire is contained and dry tongue and mouth, lung-fire is contained and pharyngeal swelling sore throat, and spleen-fire is contained and dispute tooth swells, and phlegm-fire is contained and coughed the most peaceful.If The swollen migratory arthralgia caused by wind of the side of body of liver-fire, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle are not burst, and pyretic toxicity does not dissipates, or five types of jaundice yellow skin and eye, and little water If if drenching puckery, it is caused by all burning hot pent-up, only this agent energy relieving stagnation, drops phlegm-fire, and can control it.Its property is sweet cold again, kind can control thirsty, Control from tonic empty thirsty, control fire from the medicine of a cold nature thirsty, control from gas medicine and strongly fragrant yearningly control excessive thirst from blood medicine, be to control thirsty key medicine also.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen food Few, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce oncocyte The rate of increase, lower tumor tissue aggressive, improve body antitumor reaction ability.Rhizoma Atractylodis Macrocephalae volatile oil is to mice Emhorn ascites Cancer, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc. have inhibitory action.Atractylodes lactone B lumbar injection is to mice The sarcoma people.Also effect is significantly inhibited." property of medicine opinion " carries it: monarch, and sweet in the mouth is pungent, nontoxic.The main big migratory arthralgia of energy, diarrhea due to disorder of qi for many years, trusted subordinate Distending pain, the broken dyspepsia that disappears, appetizing, remove sputum, except cold and heat, let out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells vomiting, Cold type of pain in abdomen, vomits and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Rhizoma Polygonati is used as medicine with rhizome.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney benefiting functions.For treating weakness of the spleen and stomach, body is tired Weak, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat such as is quenched one's thirst the disease.The most effective in cure for diabetes.Stir-baked RHIZOMA POLYGONATI with yellow rice wine is also known as processing Rhizoma Polygonati.After steaming with the adjuvant such as wine and Semen sojae atricolor for clean Rhizoma Polygonati, the person of being used as medicine is dried in section.Have the merit of meridians of escaping concurrently.Rhizoma Polygonati has fall blood Pressure, blood sugar lowering, blood fat reducing, atherosclerosis, slow down aging and antibacterial etc. acts on, and polygonatum polysaccharide has immune activation and makees With.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough etc. of YIN-deficiency of the lung and kidney.For weakness of the spleen and stomach.Both tonifying spleen-yin, again strengthening the spleen Gas, obtains dizzy for deficiency of kidney essence, soreness of the waist and knees, early whitening of beard and hair and quenching one's thirst.Rhizoma Polygonati strengthening bone and muscle, benefit marrow, bleach and send out；Suitably Few for the cough expectorant caused by lack of lung-YIN, dry cough without phlegm, the disease such as hemoptysis.

Fructus Corni sour in the mouth, adstringency, tepor.Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, the acid of waist knee joint Bitterly, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapses, and interior-heat quenches one's thirst, and for astringent drug, it contains cornin, Mo Luo Iridoid glycosides and Saponin, ursolic acid, the winestones such as glycoside, 7-O-methyl not sieve glycoside, Cornuside, sweroside, loganin The multiple active ingredients such as acid, gallic acid, malic acid, Fructus Corni tannin 1,2,3.There are obvious diuresis, blood fat reducing, antibacterial and rising The effect of blood leucocyte, to disease and the something lost caused by deficiency of kidney yin such as the vertigo and tinnitus caused by treatment deficiency of both the liver and kidney, the soreness of waist The diseases such as essence, frequent micturition have obvious curative effects.It is usually used in the menorrhagia caused by human female void because it has astringing to arrest bleeding effect again, collapses Leakage carries inferior disease, and the commonly encountered diseases of andrology, gynecological is all had good therapeutical effect, is largely used to the production of tonification medicine, therefore quilt It is classified as one of 40 kinds of large kinds of traditional Chinese medicines, has market widely at Chinese medicine circle.

Fructus Schisandrae Chinensis temperature；Sour, sweet；Return lung, the heart, kidney channel；Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, Emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, deficient pulse of losing heart, and interior-heat is quenched one's thirst, palpitation and insomnia." this Grass is through dredging " carry: the main QI invigorating person of Fructus Schisandrae Chinensis, all gas of lung master, acid can be received, and is just entering lung tonifying the lung, therefore QI invigorating is also.Its main cough with dyspnea person, The deficiency of vital energy is then above stopped up and is not returned unit, and sour flavor having the property of astringing is taken the photograph gas and returned unit, then cough with dyspnea is from removing.Impairment caused by overstrain is won thin, tonifying for the deficiency, reinforcing YIN-essence, benefit Man's essence." not Lu " supports the five internal organs, heat extraction, flesh person in raw the moon, the special the kidney invigorating of Fructus Schisandrae Chinensis, tonifying five ZANG-organs of holding concurrently, kidney storing essence, and essence is contained then cloudy strong, Receipts are taken the photograph, and vital qi returns unit, and public region is warmed up, digesting food, steam waste matter and change precise and tiny, the most smart spontaneous, and essence is raw then cloudy long, thus main as above All diseases are also.

Radix Codonopsis is traditional tonic that China is conventional, and ancient times are top grade with the Radix Codonopsis that area, Shangdang, Shanxi produces, and have benefit Middle QI invigorating, effect of strengthening spleen and tonifying lung.Modern study, Radix Codonopsis contains various saccharides, phenols, sterol, volatile oil, baicalin glucose Glycoside, Saponin and Alkaloid, have enhancing immunity, expansion blood vessel, blood pressure lowering, improve the work such as microcirculation, enhancing hemopoietic function With.In addition the leukopenia caused chemotherapy radiotherapy has castering action.Radix Codonopsis has invigorating the spleen and replenishing QI, effect of strengthening spleen and tonifying lung. For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI, With taste, relieving thirst and restlessness.Middle feeble QI is weak, in order to adjust benefit, the most smooth and proper.”

Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, after mixing steaming with Semen sojae atricolor liquor Dry and be used as medicine for Radix Polygoni Multiflori Preparata.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treating scrofula Scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation；Radix Polygoni Multiflori Preparata function invigorating the liver and kidney, benefiting essence-blood, crow beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, Vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body are empty.Radix Polygoni Multiflori Preparata of the present invention It it is the good merchantable brand of invigrating kidney.

Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, and belongs to goatweed, is a kind of first-class Chinese crude drug, has YIN nourishing effect of enriching blood, Can be used for blood deficiency and yellow complexion, dizziness, palpitation and insomnia, menoxenia, the disease such as metrorrhagia, also can be used for the hectic fever hectic fever due to YIN-deficiency of deficiency of kidney yin, robber Antiperspirant, pass out semen, the disease such as quench one's thirst, be one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.This quality is moistened into kidney, kind taste Tonifying kidney-yin, life essence-filling, marrow-benefitting, for the key medicine of tonifying kidney-yin.Ancients call it " big tonifying five ZANG-organs is Kidney-Yin ", " the true water of big benefit ".Often and Rhizoma Dioscoreae, mountain Fructus Evodiae equivalent use, treats the hepatic and renal YIN deficiency, soreness of the waist and knees, seminal emission, night sweat, tinnitus, deafness and quench one's thirst, can invigorating the liver and kidney, beneficial marrow, Such as LIUWEI DIHUANG WAN.

Fructus Lycii: sweet, flat.Folium Lycii: bitter, sweet；Cool in nature.Function: Fructus Lycii: nourishing the liver, nourishing kidney, lung moistening.Folium Lycii: qi-restoratives benefit Essence, clearing away heat to improve acuity of vision.Lycium barbarum polysaccharide is a kind of water soluble polysaccharide, is topmost active component in Fructus Lycii, and relative molecular mass is 68-200, becomes domestic and international study hotspot.The most again with immunomodulating and the most study of antitumor action of lycium barbarum polysaccharide.Existing Existing a lot of research show lycium barbarum polysaccharide have promotion immunity, defying age, antitumor, removing free radical, resisting fatigue, radioprotective, Protect the liver, reproductive function protection and the effect such as improvement.

Fructus Ligustri Lucidi is for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.. This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly take effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii equivalent use, control beard and hair early In vain, often join the same use of Fructus Mori, fever due to yin deficiency, often join Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, beard and hair The whitest, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains neat pier Fruit acid, to rat skin lower injection, it is possible to decrease serum glutamic pyruvic transminase, has the hepatic injury of Carbon Tetrachloride Induced and substantially protects work With, and liver cell regeneration can be promoted. oleanolic acid also can make in liver that triglyceride accumulation reduces, hepatocellular degeneration necrosis substantially subtracts Gently, glycogen accumulation increases, serum γglobulin declines；Hepatocyte mitochondrial swelling seen from ultrastructure becomes with endosomal vesicle Property alleviates, hepatic tissue interstitial inflammation habituation.

Rhizoma Curculiginis has reinforcing the kidney and supporting YANG, benefiting essence-blood, bone and muscle strengthening and the effect of promoting the circulation of blood detumescence, is mainly used in insufficiency of kidney-YANG, sexual impotence The diseases such as seminal emission, chronic consumptive disease internal injury and bones and muscles pain.Modern pharmacology activity research display Rhizoma Curculiginis has regulation immunity, antioxidation, guarantor Liver, hyperglycemia, kidney invigorating and YANG supporting and osteoporosis, antiinflammatory and adaptation former state etc. act on.

Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis；Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis etc..Pharmacology Learning research and have function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, coronary dilating etc. acts on.All herbal medicine, can flu-prevention, Control heatstroke, catch a cold, heavy sensation of the body of having a headache, suffer from abdominal pain, vomit, chest and diaphragm distension, vapour lock dyspepsia, food stagnation of child abdominal distention, diarrhoea, menorrhagia, The diseases such as bleeding not during menses, skin itching and edema, its heat radiation is delivered function, is especially better than Herba Menthae.In Yunnan, Guizhou, Sichuan San Sheng make Herba Moslae purchase and use.Herb can carry again aromatic oil, fresh stem and leaf oil-containing 0.07-0.2%, scapus leaf oil-containing 0.15-4%, oil Proportion (15 DEG C) 0.868-0.910, optical rotation (20 DEG C)-20 °-70 °, alcohol content (in terms of cephrol) 2-3%, containing phenol amount (with Thymol meter) containing about 7%, in addition to for preparing essence, also act as distillers yeast dispensing.In addition it is again good nectariferous plant.[2]

Radix Polygalae is warm in nature, bitter in the mouth, pungent, has Fructus Alpiniae Oxyphyllae of calming the nerves, the function eliminated the phlegm, subside a swelling, the insomnia caused for disarmony between the heart and kidney Dreaminess, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Shennong's Herbal: main cough with dyspnea damaging the spleen and stomach, mends Deficiency, evil removing gas, profit nine orifices, Fructus Alpiniae Oxyphyllae is intelligent, and normal hearing and eyesight is not forgotten, strong will times power.Compendium of Material Medica: Radix Polygalae, enters kidney meridian Warp, non-heart channel medicine is also.Its merit specially in strong will benefit essence, is controlled forgetful.The institute of lid essence and will, all kidney channel hides also.Kidney channel is not enough, then ambition Decline, it is impossible to above lead in the heart, therefore confuse forgetful." Lingshu Jing, Miraculous Pivot " cloud, kidney storing essence, essence conjunction will, unchecked rage tending to damage the will of the kidney, will is hindered then Its foreword of forgetfulness, spinal column cannot bend and stretch in pitching, withered skin and hairs.Cloud again, the forgetful person of people, QI of the upper portion of the body being insufficient, the therapeutic method to keep the adverse QI flowing downwards has a surplus, the intestines and stomach Real and cardiopulmonary are empty, void then seek defend stay under, for a long time it, not with time on, therefore forgetful also.Speak out " three categories of etiologic factors side " Radix Polygalae wine and control carbuncle, cloud There is outstanding service, cover the Li Er of also the kidney invigorating.

Radix Notoginseng hardship sweet, micro-, temperature.Return liver, stomach warp.Effect dissipating blood stasis stops blooding, subduing swelling and relieving pain.Cure mainly for spitting blood, spit blood, nosebleed Blood, has blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling." book on Chinese herbal medicine is looked for the truth ": specially enter liver stomach.Double enter heart large intestine.Have another name called mountain Paint.Shi Zhen says.Or cloud energy alloy skin ulcer.As painted viscous thing also." Bencao Congxin ": dissipate blood analgesic therapy.Control hematemesis and epistaxis.Dysentery metrorrhagia.Mesh Red carbuncle.

The main active ingredient of Herb Gynostemmae Pentaphylli be gypenoside, Herb Gynostemmae Pentaphylli glucoside (polysaccharide), water-soluble amino acid, flavonoid, Multivitamin, trace element, mineral etc..Medical material Ji Yuan: for the herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli.Nature and flavor: bitter in the mouth；Micro- Sweet；Cool in nature.Gui Jing: return lung；Spleen；Kidney channel.Effect: replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing.Effect is classified: qi-restoratives medicine；Change Expectorant medicine；Antipyretic.Cure mainly: body void is weak；Nephrasthenia emission；Leukopenia；Hyperlipemia；Viral hepatitis；Chronic gastrointestinal Scorching；Chronic tracheitis.

Radix Rhodiolae (formal name used at school: Rhodiola rosea L.), another name: Rhodiola rosea L., sweep sieve agate boolean (Tibetan name) etc.；For Herbaceos perennial, high 10-20 centimetre.Root is sturdy, cone, and meat is isabelline, the most fibrous root of collar portion tool, and rhizome is short, Thick shape, cylindrical, by the lepidiod leaf of most imbricate arrangements.It is grown in the high and cold pollution-free area of height above sea level 1800-2500 rice, Its growing environment is severe, thus has the strongest vitality and special adaptability.Can make medicinal, it is possible to QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae Nourish heart, be to act on Chinese medicine widely simply.Also there is the biggest cosmetic result, skin care item can be made, it is possible to be edible.Have QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae is nourished heart, effect of hemostasis with astringents, dissipating blood stasis for subsidence of swelling.Cure mainly deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, cough up Blood, leucorrhea diarrhoea, traumatic injury etc..First medical science ancient books and records Shennong's Herbal of ancient Chinese, is classified as Radix Rhodiolae in medicine Product, take Radix Rhodiolae and make light of one's life by commiting suicide QI invigorating, the most always prolong life, and nontoxic many clothes, long clothes are not hurted sb.'s feelings.Energy the kidney invigorating, regulates the flow of vital energy and nourishes blood, and cures mainly the whole body the most weary Power, uncomfortable in chest etc.；Also there is promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the effect under leukorrhagia stopping.

Spica Prunellae has the effect of improving eyesight of relieving inflammation or internal heat, and can control conjunctival congestion and swelling pain, headache etc..This product decoct, water-leach liquor, alcohol-water Leachate and alcohol leaching liquid all can obviously reduce laboratory animal blood pressure, and stem, leaf, fringe and herb all have a hypotensive effect, but fringe Act on more apparent；This product water decoction-alcohol sedimentation liquid mouse peritoneal is injected, and has obvious antiinflammatory action；This product decoct is in vitro to dysentery bar Bacterium, Bacillus typhi, vibrio cholera, escherichia coli, Bacillus proteus, staphylococcus and Bacillus tuberculosis all have certain suppression to make With.Spica Prunellae compatibility Radix Angelicae Sinensis, Radix Paeoniae Alba Spica Prunellae liver heat removing scattered silt；Radix Angelicae Sinensis, the Radix Paeoniae Alba nourish blood and enrich blood. and three 5 is with having solution stagnation of liver-QI, nourishing the liver Effect of blood is used for treating all diseases caused by hepatic depression and blood deficiency. Spica Prunellae compatibility Flos Chrysanthemi Spica Prunellae clearing away liver-fire, suppressing the hyperactive liver sun；Flos Chrysanthemi heat clearing away is cool Liver. Papillary have liver heat removing, cool liver, suppressing the hyperactive liver merit for treating flaming up of liver-fire, wind-heat of liver channel causes conjunctival congestion and swelling pain；Or on liver-yang High cause headache, dizziness.

Radix Bupleuri nature and flavor are bitter, be slightly cold, and return liver, gallbladder meridian.There are reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, cold and heat Contact, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.Reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, yang invigorating is lifted Fall into, preventing the attack (or recurrence) of malaria of bringing down a fever." herbal classic is met former ": " Radix Bupleuri, children's's five kinds of child malnutrition is won heat, all malaria cold and heat, suitable used it.Varioliform exanthema has cold and heat after seeing a little, Or the lower heat and pain of the side of body, with it in expelling pathogenic factors from the exterior medicine, do not make heat stay in shaoyang channel, then in the future without the trouble grited one's teeth.”

Stigma Maydis sweet in the mouth, light, property is put down.There is inducing diuresis to remove edema；Effect of liver heat removing function of gallbladder promoting.Main edema, dribbling urination, jaundice, gallbladder Capsulitis, cholelithiasis, hypertension, diabetes, galactostasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the wide intestinal therapeutic method to keep the adverse QI flowing downwards.Control married woman's breast to tie, galactostasis, red Swollen pain, heating of being afraid of cold, headache body is stranded." south of the Five Ridges gather medicinal herbs record ": and Carnis Sus domestica decocts soup and controls diabetes.Control again dribbling urination sandstone, bitter Unbearably painful, pan-fried soup is taken in small doses at short intervals.

The flat sweet in the mouth of Semen Platycladi, the heart, kidney, large intestine channel.Tool tranquilizing by nourishing the heart, effect of loosening bowel to relieve constipation.Control palpitation with fear, have a sleepless night, lose The diseases such as essence, night sweat, constipation, energy tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine makes the secret disease that Dengs." medicine Change justice ": Semen Platycladi, the saturating heart of fragrance, body profit grows blood.Same Poria cum Radix Pini, Semen Ziziphi Spinosae, the Radix Rehmanniae, Radix Ophiopogonis, for product clear in turbid, cure mainly mind void timid, Palpitation with fear severe palpitation, color is wan and sallow, skin pruritus due to dryness, and the merit of the blood that all nourishes heart is also.Take again abnormal smells from the patient the denseest, turbid in return kidney, same to Radix Rehmanniae Preparata, Carapax et Plastrum Testudinis, Fructus Lycii, Radix Achyranthis Bidentatae, for packing bone marrow, cure mainly damage of kidney-YIN, back severe disease, and foot knee joint is weak, and the dry power of night sweat due to yin deficiency, all nourishing kidney is also. Sweet in the mouth also can delay liver, and the deficiency of tonifying liver gallbladder is the most reliable, but the flat power of property is delayed, the most multiplex for wonderful.

Semen Plantaginis this product is sweet in flavor and cold in property, enters kidney, bladder, liver, lung meridian, function relieving stranguria by diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, Removing heat-phlegm, for medicinal herbs most in use.Diuretic, heat clearing away, improving eyesight, eliminate the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough Coughing excessive phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view." herbal classic ": " main stranguria due to disorder of QI, pain relieving, dredging water passages urine, dehumidify numbness." Collective Notes to the Canon of Materia medica: " is main Asthenia." " not Lu ": " man's damaging the spleen and stomach, woman drenches drip, loss of appetite.Support lung reinforcing YIN-essence benefit essence.Swelling pain is treated in improving eyesight.″

The Rhizoma Anemarrhenae is bitter, cold.Return lung, stomach, kidney channel.Effect clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.Cure mainly calentura excessive thirst, lung-heat type cough, bone Steaming hectic fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.This product matter cold in nature is moistened, and has a laxation effect, therefore Deficiency and coldness of spleen and stomach, diarrhea with loose stool person avoid clothes.

Specific embodiment 1:

First Semen Cuscutae is screened, dry in the sun；

Being steeped by Semen Cuscutae into ethanol, extraction, as component 1 again；

Again by remaining raw material Herb Gynostemmae Pentaphylli, Herba Artemisiae Scopariae, Rhizoma Polygonati, Fructus Corni, Radix Notoginseng, Herba Rabdosiae Lophanthoidis, Radix Codonopsis, Fructus Lycii, Radix Polygoni Multiflori Preparata is ripe Ground, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, Radix Polygalae, Radix Rhodiolae, Radix Trichosanthis, Radix Paeoniae Rubra, Rhizoma Curculiginis, Stigma Maydis, Semen Platycladi, Semen Plantaginis, Radix Bupleuri, The Rhizoma Anemarrhenae, Spica Prunellae, extracts, as component 2；

By two kinds of component mixing, add Mel or dextrin mediation ultraviolet radiation for sterilizing and disinfecting bottling.

Specific embodiment 2:

Maturation of gathering in 9～October Semen Cuscutae fruit, together cuts off with host, dries, lay seed, and decontamination of winnowing with a dustpan is washed Only, dry.About 5000g, puts into the Semen Cuscutae that dry in the sun is good in the pot that completes and goes green grass or young crops, complete 30-45 minute at 70-100 DEG C, Stir-fry in being then placed in big iron pan, start to stir-fry 20-30 minute, naturally shady and cool after taking-up；By Semen Cuscutae bubble good for dry in the sun Enter in 10 times amount ethanol after 24 hours, heating extraction 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-110 mesh Filter, then the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 through damming, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C The extractum of 1.36, heating is concentrated into paste, stand for standby use, becomes component 1.

Take other raw materials Herb Gynostemmae Pentaphylli 1200g, Herba Artemisiae Scopariae 1200g, Rhizoma Polygonati 1100g, Fructus Corni 1200g, Radix Notoginseng 1200g, small stream again Dendrobium denneanum Kerr. 1100g, Radix Codonopsis 1200g, Fructus Lycii 1200g, Radix Polygoni Multiflori Preparata 1100g, Radix Rehmanniae Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1200g, Fructus Schisandrae Chinensis 1200g, female Loyal sub-1200g, Radix Polygalae 1200g, Radix Rhodiolae 1100g, Radix Trichosanthis 1200g, Radix Paeoniae Rubra 1200g, Rhizoma Curculiginis 1100g, Stigma Maydis 1200g, Semen Platycladi 1200g, Semen Plantaginis 1200g, Radix Bupleuri 1200g, Rhizoma Anemarrhenae 1100g, Spica Prunellae 1200g, add in the ethanol of 5-10 times amount Soaking 24 hours, heating extraction 2 times, each 1-2 hour, take supernatant, united extraction liquid, 100-120 mesh filters, then through damming Molecular weight is the ultrafiltration post ultrafiltration of 5000-10000, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating It is concentrated into paste, stand for standby use, becomes component 2.

Two kinds of components being inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted economic benefits and social benefits again and is concentrated in vacuo In device, it is concentrated into every 1ml crude drug amount Han 0.1g, then adds Mel and be in harmonious proportion, become oral liquid.

Specific embodiment 3:

Maturation of gathering in 9～October Semen Cuscutae fruit, together cuts off with host, dries, lay seed, and decontamination of winnowing with a dustpan is washed Only, dry.Semen Cuscutae about 4000g good for dry in the sun, soaked and be placed in lid stainless steel cask, added 70% ethanol, matter Amount, for coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；To filter bottom percolator Drug sample after moistening expansion is mixed pine and is done to dissipate by plate gauze bag parcel again after paving, then contain powder, uniformly with rustless steel spoon Loading percolator, fill 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitably pressurize, Medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the blowing below percolator Valve, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about About 20L, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation speed general For 1000g medical material outflow per minute 2～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into liquid container；Will Percolate merges standing, and stand for standby use, as component 1.

Taking other raw materials Herb Gynostemmae Pentaphylli 1100g, Herba Artemisiae Scopariae 1200g, Rhizoma Polygonati 1100g, Fructus Corni 1200g, Radix Notoginseng 1200g, small stream is yellow Grass 1100g, Radix Codonopsis 1200g, Fructus Lycii 1200g, Radix Polygoni Multiflori Preparata 1100g, Radix Rehmanniae Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1200g, Fructus Schisandrae Chinensis 1200g, Fructus Ligustri Lucidi Sub-1200g, Radix Polygalae 1200g, Radix Rhodiolae 1100g, Radix Trichosanthis 1200g, Radix Paeoniae Rubra 1200g, Rhizoma Curculiginis 1100g, Stigma Maydis 1200g, cypress Sub-core 1100g, Semen Plantaginis 1200g, Radix Bupleuri 1200g, Rhizoma Anemarrhenae 1100g, Spica Prunellae 1200g, take crude drug clean dry；Soak water In 12 hours, be then placed in extraction pot heated and boiled 1 hour, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 45 Minute, to filter, filtrate is standby；Filtering residue adds water, for the third time heated and boiled half an hour, filters；Three filtrates are combined, powder End is placed in 70-90% ethanol immersion 1-2 hour, is heated to 60 DEG C-70 DEG C in water-bath, extraction 2h, every 10min stirring one Secondary, by filtered through gauze, residue adds 50-60% ethanol, 60 DEG C-70 DEG C are continued extraction 2h, every 10min and stir once, gauze Filter, merge lixiviating solution, be condensed into pasty state, become component 2；Component 1 and component 2 are mixed.Then add Mel to be in harmonious proportion, make oral Liquid；Ultraviolet disinfection, packs and get final product.

Specific embodiment 4:

Maturation of gathering in 9～October Semen Cuscutae fruit, together cuts off with host, dries, lay seed, and decontamination of winnowing with a dustpan is washed Only, dry.About 3500g, then take other raw materials Herb Gynostemmae Pentaphylli 1100g, Herba Artemisiae Scopariae 1200g, Rhizoma Polygonati 1100g, Fructus Corni 1200g, three Seven 1200g, Herba Rabdosiae Lophanthoidis 1100g, Radix Codonopsis 1200g, Fructus Lycii 1200g, Radix Polygoni Multiflori Preparata 1100g, Radix Rehmanniae Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1200g, the five tastes Sub-1200g, Fructus Ligustri Lucidi 1200g, Radix Polygalae 1200g, Radix Rhodiolae 1100g, Radix Trichosanthis 1200g, Radix Paeoniae Rubra 1200g, Rhizoma Curculiginis 1100g, beautiful Rice palpus 1200g, Semen Platycladi 1100g, Semen Plantaginis 1200g, Radix Bupleuri 1200g, Rhizoma Anemarrhenae 1100g, Spica Prunellae 1200g, by all raw materials Put in 10 times amount ethanol, heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged and stands；Again by above-mentioned second The medicinal residues of the component raw medicinal material of alcohol extraction add 10 times amount water heating and refluxing extraction 2 times, each 1～2 hour, extract 2 times Liquid merges standing；Being merged by above two extracting solution, concentrating under reduced pressure relative density is the filtrate of 1.35 (80 DEG C), reclaims ethanol, By gained filtrate adjustment proportion to 1.06, reduce pressure to obtain extractum, then adds Mel and is in harmonious proportion, city oral liquid, ultraviolet disinfection, and packaging is i.e. ?.

Pharmacological toxicity is tested

One, test material:

(1) laboratory animal: mouse NIH, body weight 25-28g, male and female half and half；Rats Wistar body weight 130-160g, male and female Half and half, rat, the feedstuff of mice are provided by Shandong medical college animal experimental center.

(2) test medicine:

1, medicine of the present invention: the oral liquid that embodiment 2 is made, should with distilled water diluting during three batch equal amount of mixture experiments With.

2, positive control medicine: JINGUI SHENQI WAN, commercially available.

Two, test method and result:

(1) healthy mice 80 of body weight 25-28g is taken, female, male half and half, it is respectively classified into four groups by sex and body weight, often group 20.1, taking medicine of the present invention for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, 4.2g crude drug/kg/ D, takes positive control drug JINGUI SHENQI WAN for the 4th group, and dosage is 6g crude drug/kg/d, is used in conjunction 15 days.

Result of the test: 1,2,3 groups of mices are remarkably reinforced than 4 groups of mice sexual excitation degree, the number of copulations ratio of 1,2,3 groups of mices The number of copulations of 4 groups of mices increases by 3 times average every day.

Result of the test shows that medicine of the present invention has obvious excitation to central nervous system, so medicine pair of the present invention In regulation function of human body balance, QI invigorating, enrich blood, slow down aging enhancing metabolism, neurolysis, sexual hypofunction has treatment Foundation.

Animal acute toxicity test of the present invention

One, test material

(1) animal mouse NIH kind male and female half and half, body weight 20-22g, Shandong medical college Animal Lab. provide.

(2) test medicine: the oral liquid that the present invention is made, is diluted with distilled water into suspension.

Two, test method and result:

Mice maximum tolerance determination: take healthy mice 32, male and female half and half, divided three groups within 24 hours, gavage intestinal 0.6ml/ is only every time, and gross weight 1.8ml is equivalent to crude drug in whole 4.0g, i.e. 100g crude drug/kg/d, is equivalent to clinical 65 kilograms of people 857 times.After mice administration, feedstuff has no animal dead for 12 days and does not goes out, shows toxic reaction routinely.Hence it is demonstrated that the present invention Medicine has no side effect, and clinical practice is safe and reliable.

The long-term toxicity test for animals of pharmaceutical composition of the present invention

One, test material and method

(1) test medicine: the oral liquid (prepared by the method for embodiment 2) that the embodiment of the present invention is made.

(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight with Machine is grouped, four groups, often group 35.1, taking test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/ d.4 groups compare the distilled water to respective volume amount, rat equal gavage enteral administration, often organize and be once used in conjunction 6 months, put to death half, remaining All death in 12 days is observed in lower 1/2 drug withdrawal.

Two, test index

(1) general status includes body weight, diet, emotion, movable energy.

(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin meter Number.

(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.

(4) pathologic diagnosis: take half animal after experimental result and weigh, sacrificed by decapitation, take blood, simultaneously solution treat others for earnest, Liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.

Three, result of the test: show through rat chronic toxicity test, with heavy dose coloclysis of the present invention six months, to rat Growth, body weight increase, all have no side effect brain, Liver and kidney function.Do not find to damage to each histoorgan, the blood circulation of rat Evil changes, and medication group compares no significant difference with matched group.Illustrate that medicine of the present invention has warming and recuperating the kidney-YANG, QI invigorating, enriches blood, delays The drug effects such as old and feeble enhancing metabolism, avirulence.

Pharmacological experiment:

Clinical trial:

Materials and methods

1, material (1) animal: healthy male Wistar rat 40, body weight 180 ± 20g；Adult female rat, 150 ± 20g, 90.(animal credit number: SCX2008012621) is provided by Shandong Traditional Chinese Medicine University's Experimental Animal Center.Commonly Feedstuff: produced by Shandong Province's animal science institute, the quality certification number: Shandong animal feed 200802031.(2) main agents valeric acid Estradiol (progynova): first miraculous cure industry group (Guangzhou) branch company of France produces, lot number: 03713-2；Gentamycin: Shandong, Shandong Kang Chenxin Pharmaceutical limited company produces, and specification: 2ml:8 ten thousand u/ props up, batch number: the 01124306 quasi-font size of traditional Chinese medicines H37021973.Picric acid, heparin, normal saline, platform expect that blue solution, TYH culture fluid, distilled water Deng Dong university of TCM are attached Prepared by hospital preparation center, middle Shandong.(3) Chinese medicine preparation, JINGUI SHENQI WAN, commercially available, oral.Ball, twice on the one.

Oral liquid of the present invention: Fructus Rosae Laevigatae 30g, Herb Gynostemmae Pentaphylli, Herba Artemisiae Scopariae, Rhizoma Polygonati, Fructus Corni, Radix Notoginseng, Herba Rabdosiae Lophanthoidis, Radix Codonopsis, Fructus Lycii, Radix Polygoni Multiflori Preparata, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Fructus Schisandrae Chinensis, Fructus Ligustri Lucidi, Radix Polygalae, Radix Rhodiolae, Radix Trichosanthis, Radix Paeoniae Rubra, Rhizoma Curculiginis, Stigma Maydis, Semen Platycladi, car Front son, Radix Bupleuri, the Rhizoma Anemarrhenae, each 10g of Spica Prunellae.Prepare by embodiment method 3.

(4) instrument: key instrument: microscope: binocular microscope PHSO mono-16O0x manufacturer: the sharp rich educational facilities in Shanghai Company limited.General Instrument: syringe, irrigation stomach device, micro sample adding appliance, ice machine, homogenizer, EP pipe, mosquito forceps etc..The court carries Supply.

2. method

(1) preparation of female Mus in rutting period

All 90 female Mus, every day gavage estradiol valerate suspension 1ml, and with vaginal smear examination keratinocyte demonstrate,prove It is real that " (estradiol valerate suspension compound method: be dissolved in 30ml distilled water by 1mg estradiol valerate, makes the valeric acid of 3.3% Female two liquor-saturated solution 120ml, every ml 0.033mg Han crude drug, good the day use)

(2) male Mus packet

Male Mus packet uses random digits table, and male rat 40 is only randomly divided into 4 groups: (the rear all letters of blank group Claim blank group), overfatigue, sexual overstrain add gentamycin kidney-yang deficiency model group, (then be all called for short model group), JINGUI SHENQI WAN Treatment group (then be all called for short golden deficient ball group), treatment group of the present invention (then be all called for short invention group), often group 10.

(3) modeling

Each group experiment is carried out 5 weeks altogether, blank group: routine feeding 2 weeks；Every gavage tap water 4ml/d later, maintains 3 weeks, Model group: test the 1st week: make every male Mus with 3 rutting period the same cage of female Mus, and change female Mus in rutting period every day, to induce room (if finding pregnant female Mus, the female Mus in rutting period the most more renewed) is not saved in room；Test the 2nd week: in depth of water 50cm, water temperature 30 DEG C, In the swimming trunk of volume 0.36ml, forcing every male Mus swimming, swim every day 1 time, duration 1 hour, if finding the rat tired power of essence To the greatest extent, after sinking can not on when emerging, picked up rapidly and " make it take a momentary rest, put in water the most again, to induce overstrain Excessively；And coordinate male Mus lumbar injection gentamycin 150mg/kg every afternoon every simultaneously, rear every day gavage tap water 4ml/ D, maintains 3 weeks.Shenqi pill group: modeling method is with above-mentioned model group, and after 2 weeks, every gavage shenqi pill suspension 4ml/d is (containing crude drug 0.55g), this method perfusion maintains 3 weeks.Of the present invention group: modeling method is with above-mentioned model group, and after 2 weeks, every gavage present invention is suspended Liquid 4ml/d (containing crude drug 0.55g), this method perfusion maintains 25 days.

(4) ordinary circumstance observation

Whether record body weight, figure, coat gloss, perpendicular hair phenomenon, fear of cold are afraid of cold, whether like crowded together, instead Answer the whether shrinkage of sensitivity, autonomic activities situation, diet, defecation situation, scrotum, and a record swimming time.

(5) specimen collection

Rats by intraperitoneal injection pentobarbital that (100mg/kg), anaesthetizes, and after anaesthetizing successfully, cuts, and takes out rapidly double Kidney, bilateral kingfisher ball and attached kingfisher, peeling outer layer tissue and peplos, wash away bloodstain with normal saline, after filter paper blots surface moisture, with Analytical balance is weighed.

(6) the detection process of sperm quality

Sperm count: sperm suspension instills in cell counting pond, carries out sperm count by automatic counting of red blood.Use high power The sperm count of 5 medium squares in the big lattice of mirror counting central authorities.

Sperm mobility is analyzed: under 25 DEG C～28 DEG C of room temperatures, take the attached tail same area of starting in side, correct amount 100mg Attached start tissue, put in the vial preheated in 37 DEG C of water-baths equipped with 2ml normal saline, shred into sperm suspension.37℃ After water-bath stands 2min, draw 0.01ml, drip immediately on the blood cell counting plate of 37 DEG C of preheatings, quickly see under microscope Examine, with reference to motility of sperm grade scale, record the quantity of motile sperms at different levels in about 200 sperms, obtain its percentage rate.

Living spermatozoa percentage is observed: uses Yihong test, takes sperm suspension and firmly each 1 mixing of 5% Yihong aqueous solution, and 305 Rear high power lens inspection, the sperm lived is not colored, and dead sperm dyes pale red or faint yellow, calculates 200 living spermatozoa percentage.

Sperm Morphologic Study: sperm suspension drawn by suction pipe, filters through 4 layers of lens paper, draws filtrate smear, uses after drying Methanol fixes smin, 2% eosin stains 1h, rinses with water, is dried, and under microscope mirror, every animal checks 200 1 500 completely Sperm (every treated animal at least counts 1000 complete sperms), obtains rate of teratosperm.

(7) statistical procedures

Application SPSS13.0 Chinesizing version software carries out data process, observes each index and all uses t to check, data-x ±-s Represent.

(2) result

1. ordinary circumstance

Model group compares with blank group: the obvious weak asthenia of model group animal, lassitude, it is the most blunt, independently to react Activity reduces the most in a large number；Hogback, roll up, it is seen that multiple rats flock together, be afraid of cold performance substantially；Hair is the most sparse, fur Glossiness is poor, the most perpendicular hair phenomenon (common after swimming) often occurs；Feed, amount of drinking water all reduce；Urine amount gradually increases Many (being judged by bedding and padding dry and wet degree in cage), have thin during stool；Swimming adheres to that the time progressively shortens, owing to fatigue is not propped up, " bottoming out " is caused the most gradually to increase.

Of the present invention group: food-intake relatively model group, shenqi pill group increase, body weight relatively model group, shenqi pill group are increased slightly, medicine The thing intervention later stage erects hair phenomenon and gradually decreases, and partial rat erects hair phenomenon and disappears, and fur gloss is preferable, and autonomic activities is the most relatively Many, during swimming, anti-fatigue ability is stronger.

The deficient ball group of gold: food-intake still compared with normal group is on the low side, loses weight, and has perpendicular hair phenomenon, but relatively model group has improvement, hair Sparse phenomenon is inconspicuous, and coat gloss relatively model group makes moderate progress, and autonomic activities is general, and during swimming, anti-fatigue ability is poor.

2. testis, kidney weight

Table 1 one 1 rats with deficiency of kidney-Yang testis, the comparison of kidney weight (g)

Group	Testicular weight	Kidney weight
			Blank group	3.4789±0.2255*	2.5704±0.2598
Model group	3.24±0.2268	2.9363±0.6304
			The deficient ball group of gold	3.7222±0.2195*	3.213±0.4742
Of the present invention group	3.9231±0.3216	3.324±0.5218

Note: testicular weight: compare with model group .P ＜ 0.05

From table 1 one 1, model group is compared with blank group, and testicular weight substantially reduces, statistically significant (P ＜ 0.05), golden deficient ball group, of the present invention group compare with model group, testicular weight the most substantially increases. the most statistically significant (P ＜ 0.05), but golden deficient ball group compares with of the present invention group, the increase not statistically significant (P ＞ 0.05) of guilt ball weight.Illustrate that gold is deficient Ball, the present invention all have increases the effect of rats with deficiency of kidney-Yang testicular weight, and each group of kidney weight compares, equal not statistically significant (P ＞ 0.05).Therefore, illustrate that rat kidney total amount is had no significant effect by this experimental model and pharmaceutical intervention group.

3, sperm quantity, sperm motility.

Table 1 one 2 rats with deficiency of kidney-Yang sperm quantity (105), the comparison of sperm motility

Note: sperm quantity: compare with model group, * P ＜ 0.05；Sperm motility: compare with model group, #P ＜ 0.01, with Shenqi pill group compares, ##P ＜ 0.05

From table 1 one 2, model group rats sperm quantity, sperm motility are significantly lower than blank group (respectively P ＜ 0.05, P ＜ 0.01), of the present invention group of sperm quantity and activity ratio are above model group (respectively P ＜ 0.05, P ＜ 0.01), gold Deficient ball group activity ratio is significantly higher than model group (P ＜ 0.01), and sperm quantity is improved trend compared with model group, but without statistics Meaning (P ＞ 0.05), and of the present invention group of sperm motility is higher than golden deficient ball group (P ＜ 0.05).

Illustrate that golden deficient ball, the present invention all can improve rat spermatozoa quantity and activity ratio, and effect of the present invention is better than shenqi pill.

4. living spermatozoa percentage, abnormal rate

Table 1 one 3 rats with deficiency of kidney-Yang living spermatozoa percentage, the comparison of rate of teratosperm

Group	Living spermatozoa percentage	Rate of teratosperm
			Blank group	78.2222±4.3237#	2.01±1.25##
Model group	66.875±3.9074	3.43±0.5244
			Shenqi pill group	71.28±5.5936*	2.34±1.5593
Of the present invention group	82.312±5.6127#	2.45±1.0133&

Note: living spermatozoa percentage: compare with model group, #P ＜ 0.01, * P ＜ 0.05；Rate of teratosperm: with model group ratio Relatively, ##P ＜ 0.05 ， &P ＜ 0.02 is from table 1 one 3, and model group rats living spermatozoa percentage is substantially less than blank group (P ＜ 0.01), rate of teratosperm then higher than blank group (P ＜ 0.05), golden deficient ball group, of the present invention group compare with model group, sperm survival Rate is higher than model group (respectively P ＜ 0.05, P ＜ 0.01), and of the present invention group of ball group deficient with gold compares and be improved living spermatozoa percentage Trend, but not statistically significant (P ＞ 0.05).Of the present invention group of rate of teratosperm is significantly lower than model group (P ＜ 0.01), golden deficient ball Rate of teratosperm is then improved inconspicuous (P ＞ 0.05) by group.Visible, golden deficient ball, of the present invention group all can improve living spermatozoa percentage, fall Low abnormal rate, but effect of the present invention is slightly better than golden deficient ball.

Three, rats with deficiency of kidney-Yang effect of Sex Gland Hormone assay

Gonad axis associated hormone has very important effect, simultaneously in promoting emerald green ball sexual cell growth and development process Maintain stablizing of emerald green ball During spermatogenesis.Therefore, rats with deficiency of kidney-Yang gonad axis associated hormone is contained by the different the kidney invigorating method of further investigation The mensuration of amount, has most important theories and clinical value on disclosing different the kidney invigorating method to the impact of sexual cell and During spermatogenesis.

(1) materials and methods

1. material

(1) animal is with experiment one

(2) reagent: rat starts ketone (T), rat follotropin (FSH), rat corpora lutea generates element (LH), EUSA inspection Test agent box: ADL Products.

(3) key instrument is with experiment two

2. method

(1) animal packet, model copy, administration etc. are all with experiment one.

(2) after experiment modeling, medication takes blood respectively after terminating, measure T, FSH, LH, and experimental procedure is substantially with experiment two

(3) statistical procedures

Using SPSS13.0 software to process, the t inspection that two groups are compared, data-x ±-s represents

(2) result

1. the change of testosterone (T)

The comparison of testosterone (ng/mI) level respectively organized by table 3 one 1

Group	After modeling	After medication
			Blank group	8.5784±1.7983	9.8363±1.0709
Model group	6.6527±0,985*	6.8565±1.3841
			The deficient ball group of gold	6.6147±0.7825*	7.3152±1.1624
Of the present invention group	6.8239±1.1712*	8.3227±1.3526#

Note: after modeling, compares with blank group, * P ＜ 0.05；Of the present invention group, compare before and after medication, #P ＜ 0.05.By table 3 One 1 understand, modeling three groups, and testosterone levels all declines (P ＜ 0.05), and after medication, golden deficient ball group highland ketone level has rise trend, but Not statistically significant (P ＞ 0.05), recovers after of the present invention group of testosterone levels relatively modeling substantially (P ＜ 0.05), the present invention couple is described Rats with deficiency of kidney-Yang highland ketone level has restitution, and effect is better than shenqi pill.

2. the change of Folliculogenesis element (FSH)

The comparison of table 3 one 2 respectively group Folliculogenesis element (Iu/L) level

Group	After modeling	After medication
			Blank group	5.2434±1.9621	5.3787±1.705
Model group	3.2173±0.988*	3.1959±1.1164
			The deficient ball group of gold	2.8434±1.5472*	4.9322±1.8652
Of the present invention group	3.2225±1.3435	5.2323±1.1275#

Note: after modeling, compares with blank group, * P ＜ 0.05；Comparing before and after Yougui Wan, the kidney-Yang-Reinforcing Bolus group medication, #P ＜ 0.05 is by table 3-2 Understand, rat Folliculogenesis element level can be caused after modeling significantly lower than blank group (P ＜ 0.05), after medication, shenqi pill group and this After invention modeling, compare with model group and rats with deficiency of kidney-Yang FSH is had the trend of recovery, but not statistically significant (P ＞ 0.05), this Compare FSH level before and after invention group medication to recover substantially (P ＜ 0.05), to become apparent from comparing rise after shenqi pill group medication, but Not statistically significant (P ＞ 0.05).Illustrating that modeling process can make rat FSH level decline, rat FSH level is had extensive by the present invention Effect, and effect again is better than shenqi pill.

3. the change of lutropin (LH)

The comparison of table 3 one 3 lutropin (mIu/ml) level

Group	After modeling	After medication
			Blank group	3.9015±0.7149	4.0827±0.9956
Model group	3.1396±0.521*	2.7863±1.84
			The deficient ball group of gold	3.2155±0.5289*	3.4098±0.7299
Of the present invention group	3.3176±0.6943*	3.7434±0.7665

Note: after modeling, compares with blank group, and * P ＜ 0.05 is from table 3 one 3, and after modeling, each group rat LH level is less than Blank group (P ＜ 0,05) is statistically significant.After medication, golden deficient ball group, of the present invention group of LH level all have rise trend, but divide Not with compare not statistically significant (P ＞ 0.05) before medication.Illustrate that modeling process may result in rat LH level and declines, golden deficient ball, Of the present invention group there may be recover LH level effect, but medication the latter two compare no significant difference (P ＞ 0.05).

By modeling, model group animal occurs that the yang deficiency such as obvious weak asthenia, active movement minimizing promote unable being made The performance become；Meanwhile, also occur in that due to kidney yang deficiency, unable the rousing oneself of the mind and occur that lethargy is depressed, bradykinesia etc. Performance, hogback, rolls up, gathering etc. be afraid of cold performance belong to yang deficiency can not be warm not as good as caused；Hair is sparse, and gloss etc. owed by fur is long Phase suffers from a deficiency of the kidney, and fur loses in moistening foster caused；Feed, amount of drinking water all reduce, just the pool is probably due to insufficiency of kidney-YANG, YANG failing to warm spleen-YANG, and spleen loses strong Fortune is caused；Urine many genus insufficiency of kidney-YANG, it is impossible to caused by activating QI row water.Pharmaceutical intervention group, experimental rat Kidney-Yang Deficiency Syndrome all has difference Degree is improved, and is now compared as follows: treated animal autonomic activities of the present invention, fur gloss intensity, and especially food-intake is improved and is better than kidney Gas ball group.Shenqi pill treated animal food-intake is even not as good as model group animal, and other aspects improve no significant difference.Kidney qi is described Ball, the present invention all can improve the symptom of the insufficiency of kidney-YANG of experimental rat in various degree, and effect of the present invention is slightly better than golden deficient ball group.

People in middle age, physical function started progressively old and feeble, and this is the irreversible natural law.Go out and appear tired asthenia, libido Decline, especially precipitate psychosocial burden.Man, to the middle age, should bear family and the important task of society, the most also will be in the face of work Make the various change such as condition, physical function, in terms of dietary habit, life style and mental status, the most only carry out necessary tune Whole, physical condition could be full of energy ground and adapt to the needs of new change.Modern medicine study shows, old and feeble essence is stem cell Decline, the decline of immunity, the degeneration of tissue organ function, the decline of defying age gene；Therefore, scientist thinks and to improve The immunity of human body, the most basic way is the aging course of delaying human body.It is alive for evermore to pursue, and delays life, is that the mankind are several Dream over thousand, the problem about Human Longevity is studied the most long-term and unremittingly by human sciences family.This experiment is demonstrate,proved from a side Real, the present invention can obvious slow down aging level, and then aging can be effective against further.

Claims

1. the preparation method of the Semen Cuscutae oral liquid of a slow down aging, it is characterised in that include following aspect:

A. the screening of Semen Cuscutae, dry in the sun；

The preparation method of the Semen Cuscutae oral liquid of slow down aging the most according to claim 1, it is characterised in that described step a In, ripe Semen Cuscutae fruit of gathering in 9～October, together cut off with host, dry, lay seed, decontamination of winnowing with a dustpan, clean, shine Dry.

The preparation method of the Semen Cuscutae oral liquid of slow down aging the most according to claim 1, it is characterised in that described step b In, the Semen Cuscutae that dry in the sun is good to be soaked and has been placed in lid stainless steel cask, added mass percent 70% ethanol, quality is thick 0.8-1 times of granule, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By filter plate yarn bottom percolator Drug sample after moistening expansion is mixed pine and is done to dissipate by cloth bag parcel again after paving, then contain powder with rustless steel spoon, load uniformly Percolator, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, and loading in layer is suitably pressurizeed, and medicated powder is filled out Dress must not exceed 2/3 eminence of percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and Put a container, be then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and there have ethanol to flow out about 20L to be left The right side, closes baiting valve, covers cylinder of filtering, dipping 24 hours, then opens baiting valve and carries out percolation, controls percolation speed generally 1000g medical material outflow per minute 2～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into liquid container；To ooze Filtrate merges standing, and stand for standby use, as component 1.

The preparation method of the Semen Cuscutae oral liquid of slow down aging the most according to claim 1, it is characterised in that described step c In, take in the ethanol that other starting material left raw materials steep weight 5-10 times amount, soak 24 hours, heating extraction 2 times, each 1-2 Hour, united extraction liquid, take supernatant after standing, be then placed in concentrating under reduced pressure tank, decompression recycling ethanol, be concentrated into medicinal liquid dense Degree is 0.6g crude drug/mL, and the extractum of 1.06 when the relative density of sucking filtration to filtrate is 20 DEG C becomes component 2.

The Semen Cuscutae oral liquor of slow down aging the most according to claim 1, it is characterised in that in described step d, Extractum above-mentioned steps obtained is inserted in economic benefits and social benefits vacuum concentrator, and when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, Set to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate inserts economic benefits and social benefits vacuum again In concentrator, it is concentrated into every 1ml crude drug amount Han 0.1g；Unguentum after concentration adds Mel mediation and makes oral liquid.

6. the preparation method of the Semen Cuscutae oral liquid of a slow down aging, it is characterised in that comprise the following steps:

A. the preparation of Semen Cuscutae, as component 1；

B. remaining crude drug described chopping is extracted as component 2；

The preparation method of the Semen Cuscutae oral liquid of slow down aging the most according to claim 6, it is characterised in that described step b In, remaining raw medicinal material is mixed, shredded 100～120 mesh sieves, after sieving, fine powder is standby, and coarse granule puts into acid and alkali-resistance dipping Pot, at room temperature, impregnates 15～30 days, then heating and refluxing extraction 2 times, every time together with mass percent more than 70% ethanol 1～2 hour, 2 extracting solution are merged and stands, filter, after separation, take filtrate；By filtered through gauze, residue adds 50-60% second Alcohol, 60 DEG C-70 DEG C are continued extraction 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, and being condensed into pasty state becomes component 2。

8. the Semen Cuscutae oral liquid of a slow down aging, it is characterised in that include the crude drug of following weight portion: Semen Cuscutae 10～ 50 parts, Herb Gynostemmae Pentaphylli 10～20 parts, Herba Artemisiae Scopariae 10～20 parts, Rhizoma Polygonati 10～20 parts, Fructus Corni 10～20 parts, Radix Notoginseng 10～20 parts, small stream Dendrobium denneanum Kerr. 10～20 parts, Radix Codonopsis 10～20 parts, Fructus Lycii 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Rehmanniae Preparata 10～20 parts, the Rhizoma Atractylodis Macrocephalae 10～20 Part, Fructus Schisandrae Chinensis 10～20 parts, Fructus Ligustri Lucidi 10～20 parts, Radix Polygalae 10～20 parts, Radix Rhodiolae 10～20 parts, Radix Trichosanthis 10～20 parts, Radix Paeoniae Rubra 10～20 parts, Rhizoma Curculiginis 10～20 parts, Stigma Maydis 10～20 parts, Semen Platycladi 10～20 parts, Semen Plantaginis 10～20 parts, Radix Bupleuri 10 ～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Spica Prunellae 10～20 parts.

The Semen Cuscutae oral liquid of slow down aging the most according to claim 8, it is characterised in that include the raw material of following weight portion Medicine: Semen Cuscutae 10～30 parts, Herb Gynostemmae Pentaphylli 10～15 parts, Herba Artemisiae Scopariae 10～15 parts, Rhizoma Polygonati 10～15 parts, Fructus Corni 10～15 parts, three 7 10～15 parts, Herba Rabdosiae Lophanthoidis 10～15 parts, Radix Codonopsis 10～15 parts, Fructus Lycii 10～15 parts, Radix Polygoni Multiflori Preparata 10～15 parts, Radix Rehmanniae Preparata 10～15 Part, the Rhizoma Atractylodis Macrocephalae 10～15 parts, Fructus Schisandrae Chinensis 10～15 parts, Fructus Ligustri Lucidi 10～15 parts, Radix Polygalae 10～20 parts, Radix Rhodiolae 10～20 parts, sky Pollen 10～20 parts, Radix Paeoniae Rubra 10～20 parts, Rhizoma Curculiginis 10～20 parts, Stigma Maydis 10～20 parts, Semen Platycladi 10～20 parts, Semen Plantaginis 10 ～20 parts, Radix Bupleuri 10～20 parts, the Rhizoma Anemarrhenae 10～20 parts, Spica Prunellae 10～20 parts.

The Semen Cuscutae oral liquid of slow down aging the most according to claim 8, it is characterised in that include the former of following weight portion Material medicine: Semen Cuscutae 10～40 parts, Herb Gynostemmae Pentaphylli 10～20 parts, Herba Artemisiae Scopariae 10～20 parts, Rhizoma Polygonati 10～20 parts, Fructus Corni 10～20 parts, Radix Notoginseng 10～20 parts, Herba Rabdosiae Lophanthoidis 10～20 parts, Radix Codonopsis 10～20 parts, Fructus Lycii 10～20 parts, Radix Polygoni Multiflori Preparata 10～20 parts, Radix Rehmanniae Preparata 10～ 20 parts, the Rhizoma Atractylodis Macrocephalae 10～20 parts, Fructus Schisandrae Chinensis 10～20 parts, Fructus Ligustri Lucidi 10～20 parts, Radix Polygalae 10～15 parts, Radix Rhodiolae 10～15 parts, Radix Trichosanthis 10～15 parts, Radix Paeoniae Rubra 10～15 parts, Rhizoma Curculiginis 10～15 parts, Stigma Maydis 10～15 parts, Semen Platycladi 10～15 parts, Semen Plantaginis 10～15 parts, Radix Bupleuri 10～15 parts, the Rhizoma Anemarrhenae 10～15 parts, Spica Prunellae 10～15 parts.