CN106213514A

CN106213514A - A kind of chrysanthemum health-care oral liquid improving immunity and preparation method thereof

Info

Publication number: CN106213514A
Application number: CN201610628995.5A
Authority: CN
Inventors: 马佳
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-08-02
Filing date: 2016-08-02
Publication date: 2016-12-14

Abstract

The invention discloses a kind of chrysanthemum health-care oral liquid improving immunity, crude drug includes: Flos Chrysanthemi 10～50 parts, Herba Taxilli 10～20 parts, Rhizoma Polygonati 10～20 parts, Folium Mori 10～20 parts, Fructus Corni 10～20 parts, Rhizoma Curcumae 10～20 parts, Fructus Schisandrae Chinensis 10～20 parts, the Cortex Eucommiae 10～20 parts, Rhizoma Polygonati Odorati 10～20 parts, Herba Portulacae 10～20 parts, Radix Trichosanthis 10～20 parts, Fructus Gardeniae 10～20 parts, Cortex Lycii 10～20 parts, Herba Leonuri 10～20 parts, Cortex Albiziae 10～20 parts, Radix Rhodiolae 10～20 parts, Cortex Moutan 10～20 parts, Semen Cuscutae 10～20 parts, Herba Sedi 10～20 parts.In the present invention, Flos Chrysanthemi energy spleen invigorating lung moistening blood fat reducing, blood fat reducing, blood pressure lowering, reduction cholesterol, reduction blood glucose, make the composition of blood be purified, the present invention does not has the unpleasant taste of Chinese medicine being difficult to and swallowing, and makes people be prone to accept, can be with long-term taking.

Description

A kind of chrysanthemum health-care oral liquid improving immunity and preparation method thereof

Technical field

The present invention relates to the health product containing the raising immunity deriving from plant composition, improve immunity particularly to one Chrysanthemum health-care oral liquid of power and preparation method thereof.

Background technology

Over millions of years, the mankind are at one environment being not only suitable for existence but also being fraught with risks of life, and the mankind are able to survival, also obtain Obtained outstanding immunity.Immunity is the product of biological evolution process thus.

Immunity is the defense mechanism of human body self, is that any foreign body of human bioequivalence and the external intrusion of elimination is (viral, thin Bacterium etc.)；Process aging, damage, dead, the own cells of degeneration and identification and process vivo mutations cell and virus infects carefully The ability of born of the same parents.Immunology Today is thought, immunity is human bioequivalence and the physiological reaction getting rid of " dissident ".This is performed in human body Function is immune system.

Immunity can be divided into by the difference of its acquisition pattern: 1.Innate immunity, is that people is once being born.Such as swine fever Swinery is propagated quickly, but has no chance with the mankind.This is because the mankind innately would not obtain this disease；2.Acquired immunity, be People obtains after being born in life process naturally, or passively obtains by the method for human assistance.

The health of hypoimmunity is prone to infected or cancer stricken；Immunity is extraordinary also can produce insalubrious knot Really, as caused anaphylaxis, autoimmune disease etc..

A variety of causes makes immune system can not normally play protective effect, in the case, easily cause antibacterial, virus, Funguses etc. infect, and therefore hypoimmunity the most directly shows is exactly liable to illness.Because of the most ill, increase the weight of disappearing of body Consumption, thus typically have a delicate constitution, reductions of malnutrition, lethargy, fatigue and weak, appetite, the performance such as sleep disorder, give birth to Sick, having an injection to take medicine has become homely food.The most sick will being lot more time to is recovered, and usually recurrent exerbation.Grow this Health and intelligent development can be caused in the past bad, the most easily induced major disease.

Underlying causes be hypoimmunity or immunity unsound.When immune function of human body is lacked of proper care, or immune system is not When perfecting, following point will recurrent exerbation:--flu recurrent exerbation, tonsillitis recurrent exerbation, asthma recurrent exerbation, a gas Pipe inflammation recurrent exerbation, pneumonia recurrent exerbation, diarrhoea recurrent exerbation ... so necessarily can't neglect.

Immunity refers to that body resists external invasion and attack, safeguards the ability of homoiostasis.Air is filled with various The microorganism of various kinds: antibacterial, virus, mycoplasma, chlamydia, fungus etc..In the case of body immunity is low, they are all The pathogen of sense mornig shift can be become.Although human body can produce corresponding antibody to different pathogen, to resist subinfection again, But antibody has specificity and time-bounded, such as streptococcus antibody can only protect in short period of time body not by streptococcic again Secondary infringement, also can not resist the infection of other viruses.The people of hypoimmunity cannot resist the invasion and attack of cold virus at all, this It is only the true cause that he frequently catches a cold.

Flos Chrysanthemi, perennial catananche, is the famous and precious ornamental flower cultivated through long-term artificial selection, also referred to as skill Chrysanthemum, kind has reached over thousands of kind.Flos Chrysanthemi is one of China's ten big famous flowers, China's cultivation history of existing more than 3,000 year, China chrysanthemum Spend incoming Europe, about start at late Ming & early Qing.The wherein good fortune Flos Chrysanthemi in river, Feitian, place of production Dabieshan Mt. in Hubei Province Macheng, the Hangzhoupro of Tongxiang, Zhejiang The Dendranthemamorifolium (Huizhou City Flos Chrysanthemi) of Flos Chrysanthemi and underfooting, Mount Huang is the most famous.Originate in the Flos Chrysanthemi of Hui nationality, the Flos Chrysanthemi of Chuzhou, Sichuan The Flos Chrysanthemi in middle river, the moral chrysanthemum in Deqing, Zhejiang, the Flos Chrysanthemi (one of four-Huai medicine) of Jiyuan, Henan have the highest drug effect.Particularly Dendranthemamorifolium, it is grown among high mountain cloud and mist, adopts the anima in Mount Huang, draws the elite of South Mountain, Anhui water, and its nonstaining property is to existing For people, there is higher consumption value.

Effect of Flos Chrysanthemi and effect: taste is micro-pungent, sweet, bitter, cold nature.Energy dispelling wind and heat pathogens, liver heat removing and eyesight improving, suppressing the hyperactive liver sun, removing toxic substances. For cold anemopyretic, heating giddy；Liver Channel has heat；The many tear of conjunctival congestion, or the hepatic and renal YIN deficiency, eyes is dim-sighted；Excessive rising of liver-YANG, dizziness head Bitterly；Skin infection swells and ache.Modern times are again for coronary heart disease, hypertension.

Blood pressure lowering: Flos Chrysanthemi has blood pressure lowering, eliminates cancerous cell, coronary artery dilator and antibacterial effect, long-term drink energy Increase human body is calcareous, regulation myocardial function, reduction cholesterol, is suitable for middle-aged and elderly people and prevents to drink during epidemic conjunctivitis.

Improving eyesight: Flos Chrysanthemi, in addition to smearing eyes and can eliminating edema, usually can steep one cup of chrysanthemum scented tea and drink, can eliminate eye Eyeball is tired.If drinking the chrysanthemum scented tea of 3-4 cup every day, also there is certain effect to recovering vision.

Refresh oneself: Flos Chrysanthemi is a kind of nerve tonic, can strengthen the resistance of blood capillary, delaying sanility, physical strength reinforcing. Flos Chrysanthemi has good sedation, often eats and people's limbs can be made light, refreshment.The nutritive value of Flos Chrysanthemi

The main component of Flos Chrysanthemi has volatile oil (0.20-/0-0.85%), adenine, choline, stachydrine, echinacoside and flavone Compounds.The volatile oil composition such as mainly have Borneolum Syntheticum, Camphora, chrysanthanone and acetic acid Borneolum Syntheticum cruel, flavones ingredient has luteolin, celery Dish element, acacetin etc..Additionally, possibly together with abundant vitamin, aminoacid, trace element etc. in Flos Chrysanthemi.Vitamin E in Flos Chrysanthemi Content is higher.

Compendium of Material Medica: wind heat, ophthalmalgia is intended to take off, lacrimation, and foster mesh goes blind, makees pillow improving eyesight." herbal classic ": all dizziness due to wind swell and ache, Mesh is intended to take off, lacrimation, the dead flesh of skin, aversion to wind arthralgia chiefly caused by damp pathogen.For a long time clothes profit vim and vigour, make light of one's life by commiting suicide and resistance to always prolong life." not Lu ": treat lumbago and go happy, Except irritable feverish sensation in the chest, pacify the intestines and stomach, profit five pulse conditions of ZANG-organs, adjust extremity.Amplification on Canon of Materia Medica: have modern times more than 20 to plant, only single leaf is spent little and yellow, greenery Color depth is little and thin, should wait and the person of opening is also.

Flos Chrysanthemi dispelling wind is more weak, and heat clearing away power is good, often joins Folium Mori for affection due to external wind and heat with using, it is possible to join Radix Scutellariae, Fructus Gardeniae controls intenseness of heat Fidgety disease such as grade.Flos Chrysanthemi controls conjunctival congestion and swelling pain, no matter belongs to liver-fire or wind heat causer, all can apply, because of this product can clearing away liver-fire, again Wind heat can be dissipated, often coordinate Periostracum Cicadae, Fructus Atriplicis Sibiricae equivalent to use.Such as deficiecny of liver-YIN, eyes is dim-sighted, then the polygamy Radix Rehmanniae, Fructus Lycii equivalent are used.Chrysanthemum The merit of flower heat-clearing and toxic substances removing is favourable, for surgery key medicine, is mainly used in the disease of pathopyretic ulcer, red and swollen heat pain, swells and ache especially for furuncle Poison has good efficacy, both oral administration especially, can mash again external application.The normal product with the heat-clearing and toxic substances removing such as Herba Violae, Herba Taraxaci are joined clinically Close application.Flos Chrysanthemi energy pancake liver-yang, the vertigo that excessive rising of liver-YANG is caused, often apply with the compatibility such as Concha Margaritifera, Pueraria lobata.

Flos Chrysanthemi one medicine, mainly divides Flos Chrysanthemi, Herba Tagetis Patulae, Herba Dendranthematis indici.Yellow, Bai Liangju, has dispelling wind and heat pathogens, improves immunity, heat clearing away Effect of removing toxic substances.Flos Chrysanthemi sweet in the mouth, heat clearing away power are the most weak, are longer than raising immunity；Herba Tagetis Patulae bitter in the mouth, the power that expels the heat-evil is relatively strong, is usually used in Dispelling wind and heat pathogens；Flos Chrysanthemi Indici taste is the most bitter, and the strength of heat-clearing and toxic substances removing is the strongest.The stem of Herba Dendranthematis indici, leaf, function to spend similar, no matter for oral administration with External application, the most powerful.Folium Mori and Flos Chrysanthemi, all energy dispelling wind and heat pathogens, let out clearly lung liver, therefore swollen in affection due to external wind and heat, fever and headache and conjunctival congestion The diseases such as pain, two medicines are mutually the most auxiliary for using.But effect of Folium Mori dispelling wind lung heat clearing is preferable, therefore controls xeropulmonary cough, often with Folium Mori not Use Flos Chrysanthemi；Flos Chrysanthemi is then longer than suppressing the hyperactive liver sun, and can heat-clearing and toxic substances removing.

For most of hyperpietics, single medicine treatment still uncontrollable blood pressure, and drug dose increases Often increasing the weight of (cough caused such as ACEI) with untoward reaction, patient is often difficult to stand, at this moment according to different classes of depressor Hypotensive Mechanism on synergism so that antihypertensive effect increase and do not increase or less increase untoward reaction, Wo Menyi As select two or more antihypertensive drug use in conjunction of low dose so that reach mark blood pressure.

As the saying goes " being three points of poison of medicine ", the various health product sold the most on the market, dragons and fishes jumbled together for medicine, and great majority are simply The amusement of false propaganda, have does not only have health-care components, also results in the huge injury of the person.Chinese medicine odor is poor, A lot of people are reluctant long-term taking；Even if taking, be three points of poison of medicine, allow people's long-term taking time also produce resisting psychology.How chrysanthemum The efficacy exertion of flower does not the most injure human body to maximum, and is obviously improved mouthfeel, enables a person to accept, is that we are in the urgent need to address Problem.

Summary of the invention

The technical problem to be solved is, the immunity of modern is just becoming more and more fragile, environmental pollution, Irregular, the rhythm of life of working and resting is fast, eat unhealthy, do not know controlling desire, cause the sickness rate of various disease all constantly rising.Especially Its family of so-called office, the especially group of people at high risk of hypoimmunity.Most people are sub-health states, in overdraw originally With regard to unsound health.The symptom of most people is easy catching a cold, eyes are sour and astringent, insufficiency of the spleen weak；Lack of appetite xerostomia；Quench one's thirst；Deficiency of the kidney waist Knees soreness；Impotence and seminal emission；Tinnitus mesh is dark；Early whitening of beard and hair；Body void is won thin；Wind favus disease.What is safely and effectively active substance Health product, can be greatly improved immunity, health invigorating？Always people expect the key of solution problem.Chinese medicine odor is poor, very Many people are reluctant long-term taking；Even if taking, be three points of poison of medicine, allow people's long-term taking time also produce resisting psychology.

For solving above-mentioned technical problem, the present invention provides a kind of chrysanthemum health-care oral liquid improving immunity, its described chrysanthemum Flower health care oral liquid can include the crude drug of following weight portion: Flos Chrysanthemi 10～50 parts, Herba Taxilli 10～20 parts, Rhizoma Polygonati 10～ 20 parts, Folium Mori 10～20 parts, Fructus Corni 10～20 parts, Rhizoma Curcumae 10～20 parts, Fructus Schisandrae Chinensis 10～20 parts, the Cortex Eucommiae 10～20 parts, beautiful Bamboo 10～20 parts, Herba Portulacae 10～20 parts, Radix Trichosanthis 10～20 parts, Fructus Gardeniae 10～20 parts, Cortex Lycii 10～20 parts, Herba Leonuri 10 ～20 parts, Cortex Albiziae 10～20 parts, Radix Rhodiolae 10～20 parts, Cortex Moutan 10～20 parts, Semen Cuscutae 10～20 parts, Herba Sedi 10～20 Part.

The chrysanthemum health-care oral liquid of described raising immunity, can also include following heavy in its described chrysanthemum health-care oral liquid Amount part crude drug: Flos Chrysanthemi 10～40 parts, Herba Taxilli 10～15 parts, Rhizoma Polygonati 10～15 parts, Folium Mori 10～15 parts, Fructus Corni 10～ 15 parts, Rhizoma Curcumae 10～15 parts, Fructus Schisandrae Chinensis 10～15 parts, the Cortex Eucommiae 10～15 parts, Rhizoma Polygonati Odorati 10～15 parts, Herba Portulacae 10～15 parts, sky Pollen 10～20 parts, Fructus Gardeniae 10～20 parts, Cortex Lycii 10～20 parts, Herba Leonuri 10～20 parts, Cortex Albiziae 10～20 parts, Radix Rhodiolae 10～20 parts, Cortex Moutan 10～20 parts, Semen Cuscutae 10～20 parts, Herba Sedi 10～20 parts.

The chrysanthemum health-care oral liquid of described raising immunity, can also include following heavy in its described chrysanthemum health-care oral liquid Amount part crude drug: Flos Chrysanthemi 10～30 parts, Herba Taxilli 10～20 parts, Rhizoma Polygonati 10～20 parts, Folium Mori 10～20 parts, Fructus Corni 10～ 20 parts, Rhizoma Curcumae 10～20 parts, Fructus Schisandrae Chinensis 10～20 parts, the Cortex Eucommiae 10～20 parts, Rhizoma Polygonati Odorati 10～20 parts, Herba Portulacae 10～20 parts, sky Pollen 10～15 parts, Fructus Gardeniae 10～15 parts, Cortex Lycii 10～15 parts, Herba Leonuri 10～15 parts, Cortex Albiziae 10～15 parts, Radix Rhodiolae 10～15 parts, Cortex Moutan 10～15 parts, Semen Cuscutae 10～15 parts, Herba Sedi 10～15 parts.

For solving above-mentioned technical problem, the present invention also provides for the preparation side of a kind of chrysanthemum health-care oral liquid improving immunity Method, the preparation method of its described health care oral liquid comprises the following steps:

A. the extraction of Flos Chrysanthemi, as component 1；

B. the preparation of other raw materials, as component 2；

C. by 2-in-1 also to above two extracting solution component 1 and component, add dextrin after concentration and be in harmonious proportion, be prepared as after disinfection Health care oral liquid.

In described step a, the Flos Chrysanthemi chopping that can will gather in the fall, soaked and be placed in lid stainless steel cask, added 70% ethanol, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；Will Bottom percolator filter plate gauze bag parcel pave after again the drug sample after moistening expansion is mixed pine do dissipate, then use rustless steel Powder contained by spoon, loads percolator uniformly, fills 10-12 cm thick, even by T-bar pressure, then presses aforesaid operations, dress in layer Entering, suitably pressurize, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens percolation Cylinder baiting valve below, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and There is ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control Percolation speed is generally 1000g medical material outflow per minute 2～3ml, and filtrate puts into liquid container, and is fallen by ethanol during emptying Enter liquid container；Being merged by percolate and stand, stand for standby use, as component 1.

In described step b, remaining raw material can be steeped in 10 times amount ethanol after 2-3 days, heating extraction 2 times, each 1-2 Hour, taking supernatant, united extraction liquid, 100-110 mesh filters, then the ultrafiltration post that molecular weight is 6000-10000 through damming surpasses Filter, the filtrate of 1.25 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, stand for standby use, become component 2.

In described step c, the two kinds of extracting solution that above-mentioned steps can be extracted, put in economic benefits and social benefits vacuum concentrator and mix, First concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C of deepfreezes 24 hours；Cold preservation liquid is added The filter aid kieselguhr of 0.3%, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml extractum Han 0.1g, adds Dextrin is in harmonious proportion, and is prepared as the health care oral liquid that keeps healthy after disinfection.

For solving above-mentioned technical problem, the present invention also provides for the preparation side of a kind of chrysanthemum health-care oral liquid improving immunity Method, the preparation method of described chrysanthemum health-care oral liquid can also comprise the following steps:

A. the preparation of Flos Chrysanthemi, as component 1；

B. remaining crude drug described chopping is extracted as component 2；

C. component 1 and component 2 are mixed, add proper honey after concentration and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.

In described step a, the Flos Chrysanthemi of collection can be steeped in 10 times amount ethanol after 2-7 days, heating extraction 2 times, often Secondary 1-2 hour, taking supernatant, united extraction liquid, 100-110 mesh filters, then the ultrafiltration that molecular weight is 6000-10000 through damming Post ultrafiltration, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heat and be concentrated into paste, stand for standby use, in groups Divide 1.

In described step b, can be mixed by remaining raw medicinal material, shred 100～120 mesh sieves, after sieving, fine powder is standby, Coarse granule puts into acid and alkali-resistance infusion kettle, at room temperature, impregnates 15～30 days together with more than 70 degree ethanol, is then heated to reflux carrying Take 2 times, each 1～2 hour, 2 extracting solution are merged and stands, filter, after separation, take filtrate；By filtered through gauze, residue adds Entering 50-60% ethanol, 60 DEG C-70 DEG C are continued extraction 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, is condensed into Pasty state becomes component 2.

The present invention uses Flos Chrysanthemi to be primary raw material.Blood circulation promoting and blood stasis dispelling of the present invention, spleen invigorating lung moistening, blood fat reducing, blood pressure lowering, reduction gallbladder Sterin, reduction blood glucose, make the composition of blood be purified, but also can improve microcirculation, the fragility of reduction blood capillary, fall Its permeability low, cures mainly deficiency of YIN chronic cough；Xeropulmonary cough；Insufficiency of the spleen weak；Lack of appetite xerostomia；Add some blood circulation promoting and blood stasis dispelling, spleen invigorating profit The Chinese crude drug of wet yin nourishing, the most mouthfeel of these medical materials is light, does not affect the taste of Flos Chrysanthemi, does not has the unpleasant Chinese medicine being difficult to and swallowing Taste, make people be prone to accept, can with long-term taking, can preferably improve sub-health population easy catching a cold, eyes are sour and astringent, sleep quality not Height, insufficiency of the spleen weak；Lack of appetite xerostomia；Quench one's thirst；Deficiency of the kidney soreness of the waist and knees；Impotence and seminal emission；Tinnitus mesh is dark；Early whitening of beard and hair；Body void is won thin；Wind The symptom of favus disease, is especially suitable for the sufferer that old man, child, health are thin and weak, more can preferably reach to improve effect of immunity.

Detailed description of the invention

The health-care effect of Chinese medicine is very strong, if Western medicine easily causes health a large amount of side effect occur, makes people occur bad Reaction, the toxic and side effects effect that is little and that can take for a long time of that Chinese medicine becomes apparent from.

Human immunity is the defensive enginery of human body pathogenic microorganism etc. to external world, or perhaps system of defense, normally In the case of, it ensure that human body is not encroached on by extraneous pathogenic microorganism.The body immunity generally said refers to human body Immune system resists the ability of the infringements such as exotic disease pathogenic microorganism.In the case of body immunity is normal, human body self can Resist the infringement of considerable pathogenic bacteria, it is to avoid human body is caused damage.Immunity plays important work in human life mechanism With, and the nutrition of human body, fatigue, mood, environment, disease, medication, radiation etc. cause the immunity degradation of self.More and more Research shows, the regulation of body immunity is increasingly played a significant role by Chinese medicine.This experimental result shows, the present invention makes tea can Improve cyclophosphamide immunogenicity and decline the organ index of mouse immune organ, macrophages phagocytic capacity and the increment of T cell Ability, the tentative confirmation present invention immunity to hypoimmunity mice of making tea can have potentiation.

Flos Chrysanthemi one medicine, mainly divides Flos Chrysanthemi, Herba Tagetis Patulae, Herba Dendranthematis indici.Yellow, Bai Liangju, has dispelling wind and heat pathogens, improves immunity, heat clearing away Effect of removing toxic substances.Flos Chrysanthemi sweet in the mouth, heat clearing away power are the most weak, are longer than raising immunity；Herba Tagetis Patulae bitter in the mouth, the power that expels the heat-evil is relatively strong, is usually used in Dispelling wind and heat pathogens；Flos Chrysanthemi Indici taste is the most bitter, and the strength of heat-clearing and toxic substances removing is the strongest.The stem of Herba Dendranthematis indici, leaf, function to spend similar, no matter for oral administration with External application, the most powerful.Folium Mori and Flos Chrysanthemi, all energy dispelling wind and heat pathogens, let out clearly lung liver, therefore swollen in affection due to external wind and heat, fever and headache and conjunctival congestion The diseases such as pain, two medicines are mutually the most auxiliary for using.But effect of Folium Mori dispelling wind lung heat clearing is preferable, therefore controls xeropulmonary cough, often with Folium Mori not Use Flos Chrysanthemi；Flos Chrysanthemi is then longer than suppressing the hyperactive liver sun, and can heat-clearing and toxic substances removing.The present invention uses Flos Chrysanthemi.

Folium Mori are the dried leaves of moraceae plants Mulberry.Gather after first frost, remove impurity, dry and obtain, be that one dissipates wind heat Medicine, both oral administration, it is possible to external application.It is cold in nature, sweet in the mouth, hardship, has effect of dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, can treat Anemopyretic cold, lung-heat type cough, dizziness headache, the disease that conjunctival congestion is dim-sighted.In modern times, doctor trained in Western medicine using Folium Mori and Folium Mori biological preparation as Improve diabetes and the medicine of other various difficult miscellaneous diseases and use, it is believed that its drug effect is extremely wide.Have clearing away lung-heat and moistening for dryness, cough-relieving, Reduce phlegm and internal heat, reduce phlegm, control night sweat；Tonifying liver, liver heat removing and eyesight improving, treatment dizziness and blurred vision, have a sleepless night, eliminate eye strain；Subside a swelling, purify the blood ' treatment Dysentery, suffer from abdominal pain, lose weight, except tinea pedis, sharp large and small intestinal；Anti-stress, removing heat from blood, lowering blood pressure and blood fat, prevention myocardial infarction, brain overflow Blood, dispel headache, long hair；Blood sugar lowering, anti-sugar are sick.

Herba Taxilli (formal name used at school: Taxillus sutchuenensis (Lecomte) Danser), another name peach tree is parasitic, Melia azedarach L. Parasitic etc..Twig, Ye Mi, by brown or bronzing stellate hair, have scattered candelabra hair, sprig black sometimes, and without hair, tool dissipates Rawhide hole.Originate in the ground such as Yunnan, Sichuan, Gansu, Shaanxi, Shanxi, Henan, Guizhou, Hubei, Hunan.There is a wind-damp dispelling, liver and kidney tonifying, Bone and muscle strengthening, antiabortive effect.

Cortex Eucommiae Cortex Eucommiae free amino acid is few, a small amount of protein contained, be with most foodstuffs as complete egg In vain, the detection 8 kinds of aminoacid to needed by human can i.e. be hydrolyzed.Determine 15 kinds of mineral elements contained by the Cortex Eucommiae, wherein have zinc, The trace element such as copper, ferrum, and the macroelement such as calcium, phosphorus, potassium, magnesium.The medicinal Cortex Eucommiae, is the dry tree of the Eucommiaceae plant Cortex Eucommiae Skin, is Chinese famous and precious tonic herb.Its sweet in the mouth, warm in nature.There are liver and kidney tonifying, bone and muscle strengthening, Chong and Ren Meridians regulating, consolidate through antiabortive merit Effect.The lumbago and skelalgia or aching and limp unable that insufficiency of kidney-YANG causes can be treated, the diseases such as born of the same parents' tire that deficiency of liver-QI causes is not solid, scrotum pruritus due to damp pathogen." god Agriculture book on Chinese herbal medicine warp " in be listed in top grade.

Fructus Schisandrae Chinensis is magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill. or Central China five tastes The dry mature fruit of sub-Schisandra sphenanthera Rehd.et Wils..The former practises title " Radix Schisandrae Bicoloris ", the latter Practise and claim " Fructus Schisandrae Sphenantherae ".Pluck during fruit maturation in autumn, dry after drying or steaming, remove carpopodium and impurity." the Xin Xiuben such as Tang Grass " carry " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste ", therefore have the name of Fructus Schisandrae Chinensis.Fructus Schisandrae Chinensis is divided into two kinds of south, north.Ancient doctor Book claim it, profound and, meeting and, be listed in the top grade Chinese medicine in Sheng Nong's herbal classic the earliest, can the power of strengthening by means of tonics, medical value is high, There is the effect of building body, share treatment insomnia with fine jade treasure Ganoderma.

Cortex Lycii heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quench one's thirst, hypertension, carbuncle Swollen, malignant boil." herbal classic ": " pathogen in main five, hankers quenching one's thirst, general arthralgia." " not Lu ": " main air is wet, and lower breast side of body gas, exopathogenic heat is had a headache, and mends Internal injury great Lao is hissed suction, hard muscle, reinforcing YIN-essence, profit intestine and small intestine, resistance to cold and summer-heat.″

Fructus Gardeniae (formal name used at school: Gardenia iasminoides Ellis) is called: Yellow Fructus Gardeniae, Fructus Gardeniae, white toad, be that Rubiaceae is planted The fruit of thing Fructus Gardeniae.The fruit of Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, has hepatoprotective, profit Gallbladder, blood pressure lowering, calmness, stop blooding, the effect such as detumescence.It is usually used in treating icterohepatitis, bruise, hypertension, sugar at tcm clinical practice The diseases such as urine is sick.Containing safran glycosides base, weld can be made.

Herba Leonuri acrid in the mouth is bitter, cool, invigorates blood circulation, silt of dispelling, regulating menstruation, disappear water, treats menoxenia, and vaginal bleeding during pregnancy is had difficult labour, and afterbirth is not Under, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Herba Leonuri has inducing diuresis to remove edema, shrinks uterus work Effect, be that ancient Chinese medicine doctor is for treating gynopathic key medicine.Herba Leonuri can all herbal medicine, effective ingredient be Herba Leonuri element, Herba Leonuri is containing multiple alkaloid and benzoic acid, potassium chloride etc. such as leonurine, stachydrine, leonuridine, leonurinines.Herba Leonuri Preparation has the effect of excited animal uterus, similar to pituitrin, and uterus is had strong and lasting by Herba Leonuri extractum and decoct Excitation, not only can strengthen its contractility, its tensity and shrinkage factor can be improved simultaneously.

Spica Prunellae is pungent, bitter, cold.Return liver, gallbladder meridian, effect；Clearing away heat-fire, improving eyesight, mass dissipating and swelling eliminating.Conjunctival congestion and swelling pain, have a headache dizzy Dizzy, mesh pearl nyctalgia.This product bitter cold master enters Liver Channel, and kind removing fire from the liver is with improving eyesight.With controlling flaming up of liver-fire, conjunctival congestion and swelling pain, Folium Mori, chrysanthemum can be joined Flower, Semen Cassiae etc. are medicinal.Among this product liver heat removing and eyesight improving, nourishing the liver of slightly holding concurrently, to join Radix Angelicae Sinensis, Fructus Lycii, can be used for deficiecny of liver-YIN, mesh pearl aches Bitterly, to night more particularly；Also Rhizoma Cyperi, Radix Glycyrrhizae use can be joined, as Spica Prunellae dissipates (" Zhang Shi doctor is logical ").

Herba Portulacae, Classification system: Portulaca oleracea L. is Portulacaceae annual herb plant.Plumpness is many Juice, without hair, high 10～30cm, be born in the area without shade such as roadside, field and ruins, flower garden.All there is distribution domestic various places.This kind is eaten for medicine Dual purpose plant.Herb hyoscine, have clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, antiinflammatory, quench the thirst, diuresis；Seed improving eyesight.Modern study, Herba Portulacae is possibly together with abundant SL3 fatty acid and vitamin A sample material.SL3 fatty acid is to form cell membrane, especially brain cell Material necessary to film and eye cell membrane；Vitamin A sample material can maintain epithelial tissue such as skin, cornea and conjunctival normally Function, participates in the synthesis of rhodopsin, strengthens retinal photoreceptor performance, also assists in internal many oxidizing processs.

Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing receives antiperspirant.Controlling the chest and abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, the deficiency of YIN Heating, menoxenia, metrorrhagia, leukorrhagia." Japan hanako materia medica ": " control wind and mend consumptive disease, all diseases of main woman, and antenatal rear all diseases, the logical moon Water, relieving restlessness of bringing down a fever, QI invigorating, control the hot disease of sky row, pestilence miasma mania and irritation, married woman's blood is transported, and hemorrhoidal hamorrhage rushes down blood, hemorrhoid complicated by anal fistula carbuncle on the back, skin ulcer scabies, has a headache, Improving eyesight, conjunctival congestion, bulbar conjunctiva polyp." hepatic injury caused by D-galactosamine and SGPT are raised by Radix Paeoniae Alba extract obvious antagonism, energy Making SGPT reduce, and make hepatocellular pathological changes and downright bad recovery normal. the ethanol extraction of the Radix Paeoniae Alba can make aflatoxin B1 cause The lactic acid dehydrogenase that showed of acute liver injury of rats and the gross activity of isozyme raise and be minimized. white peony root's total glycoside can Suppression carbon tetrachloride induced mice Plasma glutamate-pyruvate transaminase and lactic acid dehydrogenase raise, and liver organization is bitten acid denaturation, necrosis has necessarily Antagonism. it is believed that, the hepatic injury caused by carbon tetrachloride is to destroy because of membrane structure generation peroxidation, makes In blood, glutamate pyruvate transaminase and lactic acid dehydrogenase raise, and white peony root's total glycoside may have protective effect to hepatocyte injury, therefore can make Transaminase reduces.

Rhizoma Polygonati Odorati, formal name used at school: Polygonatum odoratum (Mill.) Druce, for Liliaceae herbaceos perennial.Root Stem horizontal walk, meat yellow-white, close raw most fibrous roots.Blade face is green, below Lycoperdon polymorphum Vitt.Flower axil is raw, usual 1～3 pieces bunches of lifes.In Yuan Chaning State southwest, but wild distribution is the widest.Cold-resistant, the most resistance to the moon, like wet environment, suitable growth is in abundant the loosening containing humus Soil." stem is tetanic, like bamboo arrow shaft, has joint for Collective Notes to the Canon of Materia medica cloud." therefore have the name of Rhizoma Polygonati Odorati.The rhizome of plant can hyoscine, Chinese medicine name is also Rhizoma Polygonati Odorati, excavates autumn, cleans, and shines to softness, repeatedly rubs, and dry in the sun, to without hard-core, is dried, or after steaming thoroughly, Rub to translucent, dry, cut sheet or section is used.Rhizoma Polygonati Odorati is extracted flavonoid substances and is combined shape with Folium Mori extract deoxynojirimycin Become a kind of novel substance to wash pancreas sugar element (cics) clearly, there is the effects such as blood sugar lowering, blood fat, blood pressure

Fructus Corni sarcocarp is contained within 16 kinds of aminoacid, it addition, containing element necessary to a large amount of human bodies.It addition, containing raw Saponin raw sugar, polysaccharide, malic acid, tartaric acid, phenols, resin, tannin and the composition such as vitamin A, C that reason activity is stronger.Its taste Sour and astringent, there is nourishing, stomach invigorating, diuresis, invigorating the liver and kidney, the effect such as replenishing QI and blood.Cure mainly hypertension, soreness of waist and knee joint, vertigo and tinnitus, sexual impotence The diseases such as seminal emission, menorrhagia.The ripe dry fruit of Fructus Corni, is rare medicinal herbs Fructus Corni after enucleation.Really medicine is used as medicine, for receiving Holding back property hematinic and analeptic；Can stomach invigorating, invigorating the liver and kidney, eliminate-poverty blood, lumbago, nerve and the disease such as have a weak heart.Its nature and flavor are sour and astringent, enter Liver, kidney channel.Sour and astringent convergence, has the effect of nourishing liver and kidney, reinforcing the kindey to control nocturnal emission, it is adaptable to the soreness of the waist and knees caused by deficiency of the liver and kindey, seminal emission Lingering diarrhea, the disease of vertigo and tinnitus.Fructus Evodiae meat contains abundant nutrient substance and functional component, the Compendium of Material Medica collection of Ming Dynasty's Li Shizhen (1518-1593 A.D.) The experience of ancient Chinese medicine doctor application Fructus Corni, is classified as Fructus Corni controlling nocturnal emission with astringent drugs of enriching blood, liver and kidney tonifying, regulating QI, qi-restoratives, improving eyesight and keeps fit it Medicine Rhizoma Curcumae is pungent, bitter, temperature.Return liver, spleen channel.Effect removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate Distending pain, accumulation, women's blood stasis amenorrhea, traumatic injury is had a pain eating accumulation.Promoting the circulation of QI to relieve pain, removing blood stasis removing food stagnancy: for qi depression to blood stasis it Amenorrhea, chest and hypochondrium, stomachache and lump in the abdomen lump etc..Often join Rhizoma Sparganii.Promoting digestion and removing stagnation: for the stomach abdominal distention and pain of eating accumulation, Chang Peijiao Fructus Hordei Germinatus, Semen Arecae Prepareta.Rhizome claims " Rhizoma Curcumae ", hyoscine, cure mainly " coagulation of QI-blood, trusted subordinate's distending pain, lump in the abdomen, accumulation, dyspepsia does not disappears, woman Female's blood stasis amenorrhea, traumatic injury is had a pain." tuber claims " green filament Radix Curcumae ", has promoting QI circulation for relieving depression, removing blood stasis with potent drugs, the function of pain relieving.

Radix Rhodiolae: Latin name Rhodiola rosea, English name Roseroot, is Crassulaceae renascent herb or filling Wood plant, is grown in the rare wild plant in the high and cold pollution-free area of height above sea level 800 2500 meters.Owing to its growing environment is disliked Bad, as anoxia, cold drying, blast, irradiated by ultraviolet, day and night temperature big, thus there is the strongest vitality and special Adaptability.Commonly use traditional medicine for Asia, there is stimulation nervous system, increase work efficiency, allaying tiredness and prevention height Mountain diseases etc. act on.Confirmed Radix Rhodiolae is more than 200 kinds, and central about kind more than 20 is the conventional of Asia traditional medicine Medicine, the least premium Herba hylotelephii erythrosticti, Radix Rhodiolae, Rhodiola rosea L., Radix Rhodiolae etc..Especially Rhodiola rosea L., by extensively General research.Nineteen sixties Soviet scientists finds, it has adaptive significances, health can be assisted to reply steady State.That is to improve body-defence various from chemistry, the biological or stimulation of physical factor for Radix Rhodiolae.Relevant Radix Rhodiolae Research, in addition to traditional resistance to compression function, scientist is also absorbed in some new discoveries, including anticancer and anti-diabetic etc..Ming Dynasty Lee Time treasure's Compendium of Material Medica to record " Radix Rhodiolae, herbal classic is top grade, eliminating evil bad odor, mends various symptoms and signs of deficiency " be " in known tonic institute rare ". " Chinese medicine voluminous dictionary " is recorded: and Radix Rhodiolae " cold in nature, sweet-puckery flavor.Promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough.Controlling hemoptysis, spitting of blood, pneumonia is coughed.” " modern practical book on Chinese herbal medicine " says that its effect has seven, one, central inhibitory action.Two, antifatigue effect.Three, cardiotonic.Four, anti- Scorching effect.Five, suppression blood glucose rising effect.Six, Hardy dwarfing.Seven, resisting microwave radiation effect ".

Cortex Moutan, has another name called Cortex Moutan, Chinese medicine name.It is dried root bark for cohosh Paeonia suffruticosa.Originate in the ground such as Anhui, Shandong.Autumn Excavate root season, remove radicula, strip root bark, dry.Life is used or is fried and uses.Compendium of Material Medica: " nourishing YIN to lower pathogenic fire solves speckle poison, sore-throat relieving Larynx, diuresis stasis.Descendant is specially to control fire mutually with yellow tiller, does not knows that the merit of Cortex Moutan more wins also.Red colored person profit, the person of spending in vain mends, and people is also Seldom realize, preferably distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action；The first of Cortex Moutan Alcohol extraction thing has suppression Platelet；Paeonol has central inhibitory actions such as calmness, cooling, antipyretic, analgesia, spasmolytic and anti-dynamic Pulse atherosclerosis, diuresis, antiulcer etc. act on.

Rhizoma Polygonati is conventional tonic Chinese medicine, has the medication history of more than 2000 year in China, perennial for Liliaceae Polygonatum Herbaceous plant, its rhizome medicinal.Rhizoma Polygonati is flat, sweet in the mouth, returns spleen, lung, kidney channel, has effect of spleen reinforcing lung moistening, supplementing QI and nourishing YIN, uses In diseases such as treatment body void weak, shortness of breath and palpitation, dryness of the lung dry cough, tinea corporis.In recent years, Rhizoma Polygonati and HUANGJING ZANYU CAPSULE thereof are ground by people Studying carefully and deepen continuously, from Rhizoma Polygonati plant, the chemical composition of isolated has alkaloid, flavone, quinones, lignanoid, polysaccharide, steroid Body saponin and trace element etc..

Semen Cuscutae: Cuscuta chinensis is dicotyledon scammonia section plant Semen Cuscutae, Cuscuta australis, cuscuta japonica Choisy etc. Seed, can the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, effect of solid tire stopping leak.Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For Impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen kidney vaginal bleeding during pregnancy, fetal movement Uneasy, spleen is suffered from a deficiency of the kidney and is rushed down；Externally treating leucoderma.

Herba Sedi, Chinese medicine name.Dry herb for crassulaceae plants Herba Sedi.Sweet, light, cool.There are dampness removing jaundice eliminating, heat clearing away solution Effect of poison.It is usually used in jaundice due to damp-heat, dysuria, carbuncle skin infection.Return liver, gallbladder, small intestine meridian.Effect dampness removing jaundice eliminating, heat clearing away solution Poison.Cure mainly for jaundice due to damp-heat, dysuria, carbuncle skin infection.

Specific embodiment 1:

The preparation of Flos Chrysanthemi: the Flos Chrysanthemi that condition of gathering in 9～November is good, decontamination of winnowing with a dustpan, clean, dry；White by dry Flos Chrysanthemi is put in ethanol and is extracted, as component 1.

The preparation of other raw materials: other raw materials steep in 10 times amount ethanol after 2-3 days, heating extraction 2 times, becomes component 2.

Mixing: the Flos Chrysanthemi extract prepared and other raw material extracting solution are mixed, after concentration, adds dextrin, as mouth Take liquid.

Specific embodiment 2:

The Flos Chrysanthemi about 4000g chopping that autumn will gather, is soaked and has been placed in lid stainless steel cask, added 70% ethanol Liquid, quality is coarse grained 0.8-1 times, stirs, moistening airtight placement more than 1 hour, makes fully to expand；At the bottom of percolator Drug sample after moistening expansion is mixed pine after paving and is done to dissipate by portion's filter plate gauze bag parcel again, then contains powder with rustless steel spoon, Load percolator uniformly, fill 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, and loading in layer, suitably add Pressure, medicated powder loads 2/3 eminence that must not exceed percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens below percolator Baiting valve, and put a container, then it is slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol stream Go out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed Generally 1000g medical material outflow per minute 2～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into reservoir Cylinder；Being merged by percolate and stand, stand for standby use, as component 1.By remaining raw material Herba Taxilli 1000g, Rhizoma Polygonati 1000g, Folium Mori 1000g, Fructus Corni 1000g, Rhizoma Curcumae 1000g, Fructus Schisandrae Chinensis 1000g, Cortex Eucommiae 1000g, Rhizoma Polygonati Odorati 1000g, Herba Portulacae 1000g, variola Powder 1000g, Fructus Gardeniae 1000g, Cortex Lycii 1000g, Herba Leonuri 1000g, Cortex Albiziae 1000g, Radix Rhodiolae 1000g, Cortex Moutan 1000g, Semen Cuscutae 1000g, Herba Sedi 1000g, steep in 10 times amount ethanol after 2-3 days, and heating extraction 2 times each 1-2 hour, takes Clear liquid, united extraction liquid, 100-110 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 through damming, and ultrafiltrate subtracts Pressure concentrates the filtrate of 1.25, stand for standby use when relative density is 80 DEG C, becomes component 2.Two kinds of extracting solution that above-mentioned steps is extracted, Putting in economic benefits and social benefits vacuum concentrator and mix, first concentrating the filtrate to relative density when 80 DEG C is the concentrated solution of 1.32, sets to 0～5 DEG C Deepfreeze 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, It is concentrated into every 1ml extractum Han 0.1g, after adding dextrin mediation disinfection, is prepared as health care oral liquid.

Specific embodiment 3:

The Flos Chrysanthemi about 5000g chopping that autumn will gather, steeps in 10 times amount ethanol after 2-7 days by the Flos Chrysanthemi of collection, Heating extraction 2 times, each 1-2 hour, takes supernatant, united extraction liquid, and 100-110 mesh filters, then through the molecular weight that dams is The ultrafiltration post ultrafiltration of 6000-10000, the extractum of 1.36 when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C, heating is concentrated into cream Shape, stand for standby use, become component 1.By remaining raw medicinal material Herba Taxilli 1100g, Rhizoma Polygonati 1200g, Folium Mori 1100g, Fructus Corni 1100g, Rhizoma Curcumae 1200g, Fructus Schisandrae Chinensis 1200g, Cortex Eucommiae 1100g, Rhizoma Polygonati Odorati 1200g, Herba Portulacae 1100g, Radix Trichosanthis 1200g, Fructus Gardeniae 1200g, Cortex Lycii 1100g, Herba Leonuri 1100g, Cortex Albiziae 1100g, Radix Rhodiolae 1100g, Cortex Moutan 1100g, Semen Cuscutae 1100g, Herba Sedi 1200g, mixing, shredded 100～120 mesh sieves, after sieving, fine powder is standby, and coarse granule puts into acid and alkali-resistance infusion kettle, Under room temperature, impregnate together with more than 70 degree ethanol 15～30 days, then heating and refluxing extraction 2 times, each 1～2 hour, by 2 times Extracting solution merges standing, filters, takes filtrate after separation；By filtered through gauze, adding 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued Continuous extraction 2h, every 10min stir once, and filtered through gauze merges lixiviating solution, and being condensed into pasty state becomes component 2.Above-mentioned steps is carried The two kinds of extracting solution taken, put in economic benefits and social benefits vacuum concentrator and mix, and first concentrating the filtrate to relative density when 80 DEG C is 1.32 Concentrated solution, sets to 0～5 DEG C of deepfreezes 24 hours；The filter aid kieselguhr adding 0.3% by cold preservation liquid, filters, and filtrate is inserted double again In effect vacuum concentrator, it is concentrated into every 1ml extractum Han 0.1g, after adding dextrin mediation disinfection, is prepared as health care oral liquid.

Pharmacological toxicity is tested

Acute toxicity testing

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Experiment thing: this Invention decoction liquor.

Two, method:

1, LD50 calculates: using improvement karber's method, mice is randomly divided into 5 groups, often group 10, male and female half and half, by this The bright distilled water that adds dissolves, and is made into Cmax, is administered by the maximum allowable capacity of mice, and institute is followed successively by 18 to dosage by crude drug amount, 14.4,11.5,9.2,7.4 (g.kg-1), after animal fasting (can't help water) 18 hours, are administered (interval half at twice in one day Hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): take mice 20, each 10 of male and female.The present invention adds distilled water dissolve, It is made into maximum concentration, by the maximum tolerated dose of animal, can twitch with injection filling hello device and be as the criterion.Little at animal fasting (can't help water) 18 Shi Hou, is administered (interval half an hour) in one day at twice, each 0.5ml (every ml 0.36g Han crude drug), total dose be 18g crude drug/ Kg.d, 300 times of quite clinical adult's 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum allowable capacity (18g/Kg.d), have no little Mus is dead, does not i.e. measure LD50, seeks maximum tolerated dose only, in 7 day observation period, and its appetite of animal, activity, hair color, essence God's states etc. are all normal, grow normal, there are no death.I.e. select and be equivalent to 300 times of doses of clinical dosage, there is no bad instead Should occur, show that acute toxicity is minimum, MTD ＞ 18g/Kg.d.

Experimental example 2: long term toxicity test data

The present invention decocts agent through the gastric infusion long-term toxicity test for animals result of 6 months: SD rat is divided into three groups, often Organizing 30, male and female half and half (are divided into high, medium and low three dosage groups, often group 10), wherein first group through gavage to normal saline； Second group is 0.25g, 2.5g and 12.5g/kg.d through gavage to the dosage of the present invention；3rd group through gavage to the agent of lovastatin Amount is 0.5mg, 5.0mg and 50.0mg/kg.d.During being administered, observe the clinical manifestation after each treated animal is administered, blood respectively The indexs such as, blood biochemistry, organ coefficient and histopathology carry out the evaluation of drug toxicity.Result of study: major toxicity reacts Show lovastatin 50mg/kg.d and 5.0mg group, show SD rat upon administration and occur in that sialorrhea, hair be fluffy, busy, abdomen Rush down, reaction and the symptom such as step, total food ration and losing weight；Blood test display total white blood cells increased, erythrocyte Sum, content of hemoglobin and platelet count are decreased obviously (the equal ＜ of P 0.05)；Blood biochemistry checking display ALT, AST, ALP Raising 1～8 times (equal ＜ of P 0.05) with CK, creatinine and blood urea nitrogen have raised (the equal ＜ of P 0.05), but have not caused animal dead；Group Knit pathological analysis result display lovastatin 50mg/kg.d group and occur in that the Liver and kidney pathological change similar to people.And physiology salt Water group and tri-dosage groups of 0.25g, 2.5g and 12.5g/kg.d of the present invention and lovastatin 0.5mg/kg.d dosage group are whole Similar reaction does not all occur during administration, during convalescent period observes, occurs that the symptom of each treated animal of reaction fades away extensive Multiple normal condition.The visible present invention is not only able to reduce the toxic and side effects of lovastatin, and can make the clinic nothing of lovastatin Toxic agent amount increases to 5～25 times (equal ＜ of P 0.01).

Test example 3: cumulative toxicity is tested:

The present invention decocts agent to mice by 7.69,19.18 and 43.21g crude drugs/kg continuous use 15 weeks (1.0ml/100g Body weight, every day 2 times) and drug withdrawal 3 weeks after, result shows: Chinese medicine preparation of the present invention is to the hair of rat, behavior, defecation, body The indexs such as weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, and internal organs naked eyes do not find difference change Changing and histological indications shows, after medication 15 weeks and drug withdrawal 3 weeks, each internal organs of rat are all without obvious change.The present invention is described Chinese medicine preparation is little to toxicity after rat long-term prescription, does not also have difference reaction, application safety after drug withdrawal.

Pharmacological experiment illustrates:

Clinical experiment: containing Rhizoma Polygonati, Radix Rehmanniae Preparata and Gynostemma pentaphyllum in inventive formulation, there is rich in nutrition, QI and blood regulating it Effect.We observe the present invention impact on hypoimmunity mice immunologic function, existing by as follows for result of study report.

1 materials and methods

The 1.1 experiment material present invention (self-control, specification: 8g/ bottle, prepare by the method for specific embodiment 2), injection ring phosphorus Amide (Hengrui Medicine Co., Ltd., Jiangsu Prov. produces, specification: 0.1g, lot number: 20080602), phytohaemagglutinin is (purchased from Sigma Company), RPMI-1640 (purchased from Hyclone company of the U.S.), newborn calf serum (Chinese yunnan Deng Chuan Die Quan biological anteserum factory Produce, lot number: 20080607002), four thiazole salts (MTT), dimethyl sulfoxide (DMSO)；Kunming mice (test by Shandong University Animal factory produces)；Microplate reader (U.S. Thermo Fisher Scientific Co., Ltd produce, model: MultiskanMK3), (U.S. Thermo Fisher Scientific Co., Ltd produce CO2 incubator, model: Thermo Scientific 3110)。

1.2 experimental technique

1.2.1 the preparation of medicinal liquid: prepare by the preparation method of embodiment 2.

1.2.2 packet: 72 mices are divided into 6 groups, blank group (NS, 0.9% sodium chloride injection 20ml/kg), Cyclophosphamide (CTX) matched group (40mg/kg), CTX+ 2.4g/kg of the present invention high dose group (high dose group), the CTX+ present invention 0.6g/kg low dose group, often group 12.Each group 1 time/d of gavage respectively, detects the present invention to mouse immune after the continuous 14d of 1ml/d Organ, macrophage phagocytic function, the impact of lymphopoiesis situation.

1.2.3 immunologic function Testing index

1.2.3.1 immune organ quality: cervical dislocation weighs weight after putting to death mice, takes out thymus and spleen immediately, Weigh after blotting residual blood with filter paper (mg), with thymus, the ratio of quality (mg) and the weight (g) of spleen, as thymus, spleen Index, thymus (spleen) organ index=Organ weight (mg)/weight (g).

1.2.3.2 phagocytic function: put to death 3d before animal, the starch meat soup of lumbar injection 5% activates mouse macrophage, adopts With half intracorporal method detection Peritoneal Macrophage Phagocytosis, so that 100 macrophages to swallow the macrophage number of chicken red blood cell The number (phagocytic index) of (phagocytic rate) and each macrophage phagocytic chicken red blood cell is as evaluation index.

1.2.3.3T detection (mtt assay) the Con A of lymphopoiesis ability stimulates mice spleen lymphocytes proliferation ability Detection: cervical dislocation is put to death and is taken out spleen after mice under aseptic condition, with 0.9% sodium chloride solution flushing spleen surface blood, It is placed in mortar, adds RPMI1640 culture fluid, grind to form single cell suspension, with 1000r min^-1Rotating speed is centrifugal abandons supernatant, Wash 2 times with Hanks ' liquid, be resuspended in RPMI1640 culture fluid.Regulation cell concentration is to 3 × 106/ml, and point holes adds In 24 well culture plates, every hole 1ml.One hole adds 75 μ l ConA liquid, and another hole, as comparison, puts 37 DEG C, in 5%CO2 incubator Cultivating 72h, before terminating cultivating, the every hole of 4h adds 10 μ l MTT, cultivates after terminating, inhales and abandon supernatant, and every hole adds DMSO 1ml, enzyme Mark instrument surveys OD value in 570nm, deducts and is not added with the OD value in ConA hole and represents lymphopoiesis ability adding the OD value in ConA hole.

Data are analyzed by 1.3 statistical method application SPSS13.0 softwares, and measurement data represents with (-x ± s), adopts Use variance analysis.Inspection level is α=0.05.

2 results

2.1 present invention on mouse immune organ mass affect CTX matched group immune organ thymus, index and spleen index is below Blank group, statistically significant with blank group comparing difference (P ＜ 0.01).High and low dose group immunity device of the present invention Official's thymus, index and spleen index, apparently higher than CTX matched group, compare with CTX matched group, and difference is statistically significant, and (P ＜ 0.05, is shown in Table 1).

Table 1 present invention impact (x ± s, mg/g) on ionization radiation injury mouse immune organ organ index

Group	Mice (only)	Thymus index	Spleen index
				Blank group	12	8.32±0.37	7.35±0.43
CTX matched group	12	4.26±0.17Δ	4.35±0.23△
				High dose group	12	6.38 ± 0.27**	5.78 ± 0.25**
Low dose group	12	5.69 ± 0.23**	4.48±0.16*

Note: compare with blank group, Δ P ＜ 0.01；Compare with CTX matched group, * P ＜ 0.05, * * P ＜ 0.01. CTX=cyclophosphamide

2.2 present invention affect CTX matched group phagocytic percentage to mouse monokaryon one peritoneal macrophage phagocytic activity, gulp down Bite index and be below blank group, have statistics (P ＜ 0.01), high and low dose of the present invention with blank group comparing difference Group phagocytic percentage, phagocytic index apparently higher than CTX matched group, compare with CTX matched group, difference have statistics (P ＜ 0.05, It is shown in Table 2).

Table 2 present invention is on Phagocytosis By The Peritoneal Macrophages In Mice and lymphopoietic impact (-x ± s)

Note: compare with blank group, Δ P ＜ 0.01；Compare with CTX matched group, * P ＜ 0.05, * * P ＜ 0.01

Human immunity is the defensive enginery of human body pathogenic microorganism etc. to external world, or perhaps system of defense, normally In the case of, it ensure that human body is not encroached on by extraneous pathogenic microorganism.The body immunity generally said refers to human body Immune system resists the ability of the infringements such as exotic disease pathogenic microorganism.In the case of body immunity is normal, human body self can Resist the infringement of considerable pathogenic bacteria, it is to avoid human body is caused damage.Immunity plays important work in human life mechanism With, and the nutrition of human body, fatigue, mood, environment, disease, medication, radiation etc. cause the immunity degradation of self.More and more Research shows, the regulation of body immunity is increasingly played a significant role by Chinese medicine.This experimental result shows, the present invention makes tea can Improve cyclophosphamide immunogenicity and decline the organ index of mouse immune organ, macrophages phagocytic capacity and the increment of T cell Ability, the tentative confirmation present invention can have potentiation to the immunity of hypoimmunity mice.

Flos Chrysanthemi not only can effectively spleen invigorating lung moistening blood fat reducing, blood circulation promoting and blood stasis dispelling, spleen invigorating lung moistening, blood fat reducing, blood pressure lowering, reduction gallbladder Sterin, reduction blood glucose, make the composition of blood be purified, but also can improve microcirculation, the fragility of reduction blood capillary, fall Its permeability low, cures mainly deficiency of YIN chronic cough；Xeropulmonary cough；Insufficiency of the spleen weak；Lack of appetite xerostomia；Add some blood circulation promoting and blood stasis dispelling, spleen invigorating profit The Chinese crude drug of wet yin nourishing, the most mouthfeel of these medical materials is light, does not affect the taste of Flos Chrysanthemi, does not has the unpleasant Chinese medicine being difficult to and swallowing Taste, make people be prone to accept, can with long-term taking, can preferably improve sub-health population easy catching a cold, eyes are sour and astringent, insufficiency of the spleen weak； Lack of appetite xerostomia；Quench one's thirst；Deficiency of the kidney soreness of the waist and knees；Impotence and seminal emission；Tinnitus mesh is dark；Early whitening of beard and hair；Body void is won thin；The disease of wind favus disease Shape, is especially suitable for the sufferer that old man, child, health are thin and weak, more can preferably reach to improve effect of immunity.

Claims

1. the chrysanthemum health-care oral liquid improving immunity, it is characterised in that described chrysanthemum health-care oral liquid includes following The crude drug of weight portion: Flos Chrysanthemi 10～50 parts, Herba Taxilli 10～20 parts, Rhizoma Polygonati 10～20 parts, Folium Mori 10～20 parts, Fructus Corni 10 ～20 parts, Rhizoma Curcumae 10～20 parts, Fructus Schisandrae Chinensis 10～20 parts, the Cortex Eucommiae 10～20 parts, Rhizoma Polygonati Odorati 10～20 parts, Herba Portulacae 10～20 parts, Radix Trichosanthis 10～20 parts, Fructus Gardeniae 10～20 parts, Cortex Lycii 10～20 parts, Herba Leonuri 10～20 parts, Cortex Albiziae 10～20 parts, red scape They 10～20 parts, Cortex Moutan 10～20 parts, Semen Cuscutae 10～20 parts, Herba Sedi 10～20 parts.

Improve the chrysanthemum health-care oral liquid of immunity the most according to claim 1, it is characterised in that described chrysanthemum health-care is administered orally Liquid also includes the crude drug of following weight portion: Flos Chrysanthemi 10～40 parts, Herba Taxilli 10～15 parts, Rhizoma Polygonati 10～15 parts, Folium Mori 10 ～15 parts, Fructus Corni 10～15 parts, Rhizoma Curcumae 10～15 parts, Fructus Schisandrae Chinensis 10～15 parts, the Cortex Eucommiae 10～15 parts, Rhizoma Polygonati Odorati 10～15 parts, Herba Portulacae 10～15 parts, Radix Trichosanthis 10～20 parts, Fructus Gardeniae 10～20 parts, Cortex Lycii 10～20 parts, Herba Leonuri 10～20 parts, Herba Albiziae Skin 10～20 parts, Radix Rhodiolae 10～20 parts, Cortex Moutan 10～20 parts, Semen Cuscutae 10～20 parts, Herba Sedi 10～20 parts.

Improve the chrysanthemum health-care oral liquid of immunity the most according to claim 1, it is characterised in that described chrysanthemum health-care is administered orally Liquid also includes the crude drug of following weight portion: Flos Chrysanthemi 10～30 parts, Herba Taxilli 10～20 parts, Rhizoma Polygonati 10～20 parts, Folium Mori 10 ～20 parts, Fructus Corni 10～20 parts, Rhizoma Curcumae 10～20 parts, Fructus Schisandrae Chinensis 10～20 parts, the Cortex Eucommiae 10～20 parts, Rhizoma Polygonati Odorati 10～20 parts, Herba Portulacae 10～20 parts, Radix Trichosanthis 10～15 parts, Fructus Gardeniae 10～15 parts, Cortex Lycii 10～15 parts, Herba Leonuri 10～15 parts, Herba Albiziae Skin 10～15 parts, Radix Rhodiolae 10～15 parts, Cortex Moutan 10～15 parts, Semen Cuscutae 10～15 parts, Herba Sedi 10～15 parts.

4. improving a preparation method for the chrysanthemum health-care oral liquid of immunity as according to any one of claims 1 to 3, it is special Levying and be, the preparation method of described health care oral liquid comprises the following steps:

A. the extraction of Flos Chrysanthemi, as component 1；

B. the preparation of other raw materials, as component 2；

C. by 2-in-1 also to above two extracting solution component 1 and component, add dextrin after concentration and be in harmonious proportion, after disinfection, be prepared as health care Oral liquid.

Improve the preparation method of the chrysanthemum health-care oral liquid of immunity the most according to claim 4, it is characterised in that: described step In rapid a, the Flos Chrysanthemi chopping that autumn will gather, to be soaked and be placed in lid stainless steel cask, added 70% ethanol, quality is thick 0.8-1 times of grain, stirs, moistening airtight placement more than 1 hour, makes fully to expand；By filter plate gauze bottom percolator Drug sample after moistening expansion is mixed pine and is done to dissipate by bag parcel again after paving, then contain powder with rustless steel spoon, and uniform loading oozes Filter cylinder, fill 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, and loading in layer, suitably pressurize, medicated powder filling Must not exceed 2/3 eminence of percolator；Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts One container, is then slowly added into 70% ethanol；Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, Close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medicine Material outflow per minute 2～3ml, filtrate is put into liquid container, and is poured ethanol during emptying into liquid container；Percolate is merged Standing, stand for standby use, as component 1.

Improve the preparation method of the chrysanthemum health-care oral liquid of immunity the most according to claim 4, it is characterised in that described step In rapid b, remaining raw material is steeped in 10 times amount ethanol after 2-3 days, heating extraction 2 times, each 1-2 hour, take supernatant, merge Extracting solution, 100-110 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 through damming, ultrafiltrate concentrating under reduced pressure phase The filtrate of 1.25 when being 80 DEG C to density, stand for standby use, become component 2.

Improve the preparation method of the chrysanthemum health-care oral liquid of immunity the most according to claim 4, it is characterised in that described step In rapid c, two kinds of extracting solution that above-mentioned steps is extracted, put in economic benefits and social benefits vacuum concentrator and mix, first concentrate the filtrate to 80 DEG C Time relative density be the concentrated solution of 1.32, set to 0～5 DEG C of deepfreezes 24 hours；The filter aid diatom that cold preservation liquid is added 0.3% Soil, filters, and filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml extractum Han 0.1g, adds dextrin and is in harmonious proportion, disinfection After be prepared as keep healthy health care oral liquid.

8. improving a preparation method for the chrysanthemum health-care oral liquid of immunity as according to any one of claims 1 to 3, it is special Levying and be, the preparation method of described chrysanthemum health-care oral liquid can also comprise the following steps:

A. the preparation of Flos Chrysanthemi, as component 1；

B. remaining crude drug described chopping is extracted as component 2；

Improve the preparation method of the chrysanthemum health-care oral liquid of immunity the most according to claim 8, it is characterised in that described step In rapid a, the Flos Chrysanthemi of collection is steeped in 10 times amount ethanol after 2-7 days, heating extraction 2 times, each 1-2 hour, take supernatant, United extraction liquid, 100-110 mesh filters, then the ultrafiltration post ultrafiltration that molecular weight is 6000-10000 through damming, and ultrafiltrate decompression is dense The extractum of 1.36 when contracting relative density is 80 DEG C, heating is concentrated into paste, stand for standby use, becomes component 1.

Improve the preparation method of the chrysanthemum health-care oral liquid of immunity the most according to claim 8, it is characterised in that described In step b, being mixed by remaining raw medicinal material, shredded 100～120 mesh sieves, after sieving, fine powder is standby, and coarse granule puts into acid and alkali-resistance Infusion kettle, at room temperature, impregnates 15～30 days, then heating and refluxing extraction 2 times together with more than 70 degree ethanol, and each 1～2 is little Time, 2 extracting solution are merged and stands, filter, after separation, take filtrate；By filtered through gauze, residue adds 50-60% ethanol, 60 DEG C-70 DEG C continue extraction 2h, every 10min and stir once, and filtered through gauze merges lixiviating solution, and being condensed into pasty state becomes component 2.