CN101703228A - Health-care composition for strengthening immunity and preparation method thereof - Google Patents

Health-care composition for strengthening immunity and preparation method thereof Download PDF

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CN101703228A
CN101703228A CN200910212408A CN200910212408A CN101703228A CN 101703228 A CN101703228 A CN 101703228A CN 200910212408 A CN200910212408 A CN 200910212408A CN 200910212408 A CN200910212408 A CN 200910212408A CN 101703228 A CN101703228 A CN 101703228A
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portions
health
chinese
immunity
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赵祎乾
张馨
赵祎坤
马亦飞
周天易
施云西
李楚君
张丽
杨壬淦
杨豪语
李佳霏
王嫣图
戚玮琛
陆翔宇
张致恺
张雯
李慧
李旻
胡肖然
石瑛
洪小明
张爱玲
赵伟华
程鹏
冯莉
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Abstract

The invention discloses a health-care composition which is used for strengthening immunity and takes Chinese medicinal herbs as main raw materials and a preparation method thereof. The health-care composition is made in a common oral formulation (or externally applied formulation) by mainly taking Chinese medicinal herbs of flos caryophyllata, dark plum fruit, liquoric root, dahurian angelica root, honeysuckle flower, heartleaf houttuynia herb, barbary wolfberry fruit, cape jasmine fruit, Indian buead, mulberry leaf, exocarpium citri rubrum, lotus leaf, chrysanthemum, black sesame, tangerine peel, peppermint, wrinkled gianthyssop herb and the like which are edible and medicinal and appropriate imvite as raw materials in a certain weight ratio. The health-care composition mainly takes Chinese medicaments and has the health-care function of strengthening the immunity.

Description

A kind of health composition that strengthens immunity and preparation method thereof
Technical field
The present invention relates to a kind of health composition that increases immunity, specifically it is to be food, to be that the Chinese herbal medicine and an amount of imvite of medicine is that raw material is made again to have immunologic function with some, and preparation method thereof.
Technical background
In the world wide, the cause of disease specificity death rate and the incidence of disease (as following table):
Figure G2009102124084D0000011
(the data record is from " the 2009 world healths statistics " of the World Health Organization in upward showing)
Be not difficult to find out that from last data communicable disease is that the cause of disease specificity death rate is the highest, it is imperative to improve popular immunity so.Like this, people expect health, can the especially surprise attack of communicable disease of prevent disease.The present invention utilizes advanced biological purification technique and high-tech powder process technology pure Chinese herbal medicine, makes a kind of health composition that strengthens immunity, helps people to improve self epidemic prevention ability to disease.
In April, 2009, large-scale H1N1 swine influenza virus is broken out in Mexico, and current situation about breaking out about the H1N1 swine flu develops rapidly, and the country of global zones of different is affected.Minister Chen Zhu of the Ministry of Public Health says: " by October 22, the whole nation reported the Influenza A H1N1 confirmed cases 31966 examples altogether, wherein imported 2116 examples overseas, infected 29850 examples within the border, had cured 25735 examples.Bulletin of the World Health Organization, the whole world has 194 countries and regions report Influenza A H1N1 confirmed cases and surpasses 399000 examples, death 4735 examples.”
As seen, respiratory tract is the new main route of transmission of Influenza A H1N1.For the function of internal organ and appearance and with external environment, the substantial connection in season, the classical works of the traditional Chinese medical science---opinion is arranged in the Huangdi's Internal Classics: " the lung person, the dominator of QI, the position of storing soul are also; Its Hua Zaimao, it fills at skin ... ".This has just shown the sagacity of Ancient Chinese for the sage.So people protect the autoimmune function of skin, not just directly or strengthened the immune system of human body self indirectly.
The present invention's invention adds flavor according to " danxi's experiential therapy " Yupingfeng San, and the Radix picrorrhizae in the tissue substance is solely gone into blood system and heat-clearing; The Radix picrorrhizae root contains the bitter glucoside I of kutkin, Radix picrorrhizae, II, III etc., and dermatophytes such as blue hair tinea seedling are had inhibitory action in various degree. the root of Dahurain angelica, the hot temperature of distinguishing the flavor of is nontoxic, its fragrance is strong, also fragrant grass is also. hot loosing it, temperature with and it, fragrance and hot is so can moisten; Contained oxygen peucedanin in vitro test has antibacterial action to 11 kinds of bacterial strains, Imperatorin also has the antibacterial action xanthotoxin, MIC to Bacillus tuberculosis H37RV is 100mc g/ml, and the water logging agent also has certain inhibitory action to pathomycetes such as Microsporon audouinis.The pigment of the yellow that safflower contains has antifatigue effect.Tea in addition, the god that clears away heart-fire, cool liver and gall are washed heat, respectful lung stomach; Tealeaves contains fat purine Alkaloid, still contains a large amount of tannic acids in addition, so convergence, effect such as antibacterial are arranged.
By the service function of the present invention for human body contribution, make human body can therefrom obtain wind dispelling, antibiotic medicine, and and sharp blood vessels, and not withered consumption, the barrier of using of having safeguarded human body self health with then gaining everything and lose nothing.
Summary of the invention
Task of the present invention is in line with improving the policy of human body self to the immunity of disease, a kind of composition of development with increase immunity, resemble that doctor Director-General Margaret Chan of the World Health Organization says: " find realization ' people enjoys health ' target direct way ", improving people's quality of life.
Task of the present invention realizes that by following technical proposal this immunizing health composition comprises the following raw medicaments in portion by weight material:
20~120 parts of 20~90 portions of peppermints of 20~120 portions of fruits of Chinese wolfberry of 20~120 portions of dark plums of cloves
Real 20~120 parts of 10~120 portions of Chinese scholartrees of 20~120 parts of orange 20~90 parts of Poria cocos of the root of Dahurain angelica
20~120 parts of 20~120 portions of honeysuckles of 20~90 portions of fruits of Chinese wolfberry of 20~120 parts of orange peels of mulberry leaf
20~120 parts of 20~120 parts of chrysanthemums of 20~120 portions of wrinkled giant hyssops of 20~120 portions of Radix Glycyrrhizaes of bitter orange flower
50~360 parts in 50~360 parts of glutinous rice of 20~120 portions of mung beans of 20~120 portions of cordate houttuynias of rose
50~360 parts in 50~360 parts of sesame oil of 20~120 parts of honey of 20~90 portions of wrinkled giant hyssops of cape jasmine
20~90 parts of 10~60 parts of rhodiola roots of 10~60 portions of golden cypresses of 50~360 parts of roots of large-flowered skullcap of olive oil
30~180 parts of 10~60 parts of Radixs Astragali of 10~60 portions of coptiss of windproof 10~60 parts of bighead atractylodes rhizomes
10~60 parts of 10~60 parts of pearls of 10~60 parts of storaxs of 10~60 parts of purlin perfume (or spice) of Kaempferia galanga
30~180 parts of 10~60 parts of Radix Angelicae Sinensis of 10~90 portions of rhizoma cyperis of 10~60 parts of safflowers of moutan bark
10~60 parts of 10~90 portions of Asian puccoons of 10~60 parts of dragon's blood of 10~60 parts of banksia rose of agalloch eaglewood
Styrax smokes 10~60 parts of 50~360 parts of Jehol Ligusticum Rhizomes of 10~60 parts of suet of Lu Xiang for 10~60 parts
0.2~20 part of 10~90 parts of imvite of 10~60 parts of Chinese wax of 10~60 portions of Chinese honey locusts of wilsonii
In the above proportioning, the weight of the present composition is calculated with the crude drug raw material, this proportioning composition can be made into the described preparation 1000ml of capsule 1000ml. and refers to the finished product of making composite preparation of the present invention, as to make tissue substance of the present invention be 1000 of capsules, 1000 in tablet, granule 1000ml, 1000 of pills, powder 1000mg, 1000 of sublimed preparation, 1000 of pills, paste 1000ml, fat agent 1000ml or creme 1000ml etc., each 1~20ml can use 50~1000 times altogether.
When producing, can increase or reduce by the pharmacology composition of prescription and the corresponding part by weight of science, can obtain the health composition sieve side that multiple the present invention increases immunity.Is unit as large-scale production with kilogram, ton or milligram, and weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.For the colony that specific demand is arranged, can correspondingly adjust, adjustment amount increases or minimizing is no more than 100%, and effect is constant.
The present invention increases the health composition of immunity, form by above-mentioned prescription, to contain be food, be that medicine is main herbal raw material again, adds an amount of imvite, through science purification technique and the processing of high-tech superfine powder grinding technique, make by the galenic pharmacy routine techniques.Described pharmaceutically active substance can obtain by extracting herbal raw material respectively, also can obtain by the co-extracted herbal raw material.
The present invention increases the health composition of immunity, is dissolved in the characteristic of wine at active ingredient in the prior art and impurity polysaccharide etc., has proposed to prepare with wine dipper alcohol precipitation, immersion method the preparation method of described maintenance active material.
The present invention increases the health composition of immunity, also discloses a kind of said herbal medicine preparation of compositions method:
The first step: get each raw medicinal material by prescription;
Second step: respectively raw medicinal material rhodiola root, safflower are carried out vacuum drying, be lower than 10% to water content;
The 3rd step: the rhodiola root after the vacuum drying, safflower raw medicinal material were added 5~15 times of weight 42~65% liquor dippings respectively 10~40 hours, filtration residue adds 5~15 times of weight 42~65% liquor dippings again, continuous backflow 2~3 times, each 1~5 hour, merge extract and concentrate, dry, pulverized 160 mesh sieves;
The 4th step: all the other medicinal materials are with pulverizing 160 mesh sieves through rhodiola root, safflower residue behind 42~65% liquor dipping in will filling a prescription;
The 5th step: will soak after the imvite coarse crushing 24~72 hours, filter and to add water and reflux 2~3 times, the time 1~5 hour, merge maceration extract and reflux extracting liquid to concentrate, dry, pulverized 160 mesh sieves;
The 6th step: earlier, went into oil (sesame oil, olive oil) three with raw medicinal materials such as Radix Angelicae Sinensis, Radix Glycyrrhizae, Asian puccoon, the roots of Dahurain angelica, slow fire little withered look of torturing in the big spoon, thin thin,tough silk filtering in oily reentrant spoon, is fried in shallow oil and is rolled down whole dragon's bloodization to the greatest extent;
The 7th step: inferior down suet, Chinese wax (can add as external application, take and needn't add), low baking temperatureization it; A moment is waited in cooling to be cooled, grinds superfine pearl powder under the side, stirs evenly, and waits and has got to one day.
Each constituent content of pure natural composition that strengthens immunity that has that makes as stated above is that the raw material through pulverizing has a spot of loss.
Advantage of the present invention is: according to traditional Chinese medicine health theory, being food two with free of contamination, natural some is again the Chinese herbal medicine of medicine, and adding an amount of imvite is that raw material combines through scientific matching.Also be the invention provides and a kind ofly employ advanced biological purification technique and high-tech powder extra-fine grinding technology is carried out the processing of raw material, and keep its natural component, technological operation is simple, makes pulvis (the pulvis method for making promptly can be made into formed product of the present invention routinely).By serving masses, can be people provides autoprotection to reduce the barrier of virus infections.
Compared with prior art, composition provided by the invention has the enhancing body immunity.And to add conventional be capsule, tablet, granule, pill, powder, sublimed preparation, pill, paste, fat agent or creme.By the processing of wine, water and oil, promptly adopt the wine dipper alcohol deposition method, remove gelatinized starch, keep the effective active components such as alkaloid in the Chinese herbal medicine, and utilize the activation body of the special physicochemical property of imvite for preparation of the present invention, improve the absorption of preparation active ingredient.
The invention theory
Since founder, Britain's doctor's qin of the human immunity practice of 19 beginning of the century of 18 end of the centurys were received the discovery varicella vaccine, the immunity inoculation practice was day by day abundant; Pasteur (Louis's Pasteur LouisPasteur, 1821-1895.9.25, French microbiologist, chemist, modern age microbiological founder.Hew out classical mechanics as newton, Pasteur has been opened up microorganism field) " about the lactic acid fermented record " 1857 years delivered be the classical paper that microorganism educational circles generally acknowledges; Successfully develop multiple vaccines such as fowl cholera vaccine, rabies vacciness after 1880 again, its theory and immunization have caused the major transformation of medical practice.
1908, Nobel's physiology and medical science prize have been presented to because phagocytosis (English: phagocytosis, a kind of immunization ways of carrying out by white blood cell) research Russian Mei Qinikefu [И л ь я И л ь и ч М e ч н и к о в (on July 16th, 1 1916 on May 16th, 1845), be born in Ukraine, be a microbiologist of Russia and immunologist, one of pioneer of immune system research.Also because find the benefit of lactic acid bacteria to human body, make people be referred to as " father of lactic acid bacteria "], and find that trypan-red is to the specific German Ai Lixi of the treatment caused disease of trypanosoma [Ehrlich, Eugen (1862~1922), first humoral immunity theory " side chain is said " has been proposed, i.e. " acceptor is said "], this is the beginning that the physician explores modern theory of immunity.
Along with the reach of science, people recognize the extensive knowledge and profound scholarship of traditional medicine gradually.Modern pharmacological research finds, the polysaccharide in the Chinese herbal medicine has immunological regulation, effect such as antitumor, antiviral, and it is universally acknowledged that the immunoloregulation function of the Radix Astragali has obtained, Ancient Chinese generation the good recipe of bringing down a fever also cast the refreshing medicine of antimalarial of today.
Week, adopted Puritanism was awarded and team, because of initiative artemisine compound medicine---Coartem (Coartem) is won 2009 annual European inventor's prizes (non-European countries class).Up to now, Coartem (Coartem), about 630,000 people's life has been saved in assistance.And sweet wormwood in " Book of Songs ", just has such description: " ring of cry of a deer deer, the wormwood artemisia (wormwood artemisia cries sweet wormwood, abrotanum again, feverfew) of food open country ".Afterwards, in the medical book " 52 Bingfang ", just first sweet wormwood is classified as antipyretic [B.C. 340 years, alchemist of the Eastern Jin Dynasty and medical scholar Ge Hong have been situated between first the antimalarial characteristic of sweet wormwood]." General Records of Holy Universal Relief " [original name " General Records of Holy Universal Relief of having stable political situation ", (1111-1118) Song Hui ancestor Zhao Ji imperial edict collects well-known doctor through the country in the period of having stable political situation the Northern Song Dynasty, and go out to drive the mansion hide write] etc. application is all arranged in the medical book.So Chinese herbal medicine more and more obtains the numerous approval of world medical circle with its original advantage, remarkable bidirectional modulation function and less toxicity, side effect.Chinese herbal medicine for the human contribution of having done not only in the past, the present and the future can continue, and has still that more pharmacology awaits development, wider application.The Radix Astragali is generally acknowledged by common people as typical case's representative, the antibiotic effect of sweet wormwood heat-clearing of Chinese herbal medicine immunopotentiator.
The present invention increases in the health composition preparation of immunity, the sweet Wen Yiqi of the Radix Astragali, and strengthening exterior and reducing sweat then outward, interior then big tonifying spleen lung is main ingredient in the side.Bighead atractylodes rhizome strengthening the spleen and replenishing qi, the prosperous then soil of spleen can be given birth to gold, makes the lung qi abundance, to escort sun admittedly, associates with the Radix Astragali, then replenishes qi to invigorate the spleen, and the power of strengthening exterior and reducing sweat is more outstanding; Windproofly walk table and go ailment said due to cold or exposure, close the Radix Astragali, the bighead atractylodes rhizome with tonifying QI for expelling pathogen.And windproof the Radix Astragali is then eliminating evil and just do not hinder, and the Radix Astragali gets windproof then solid table and do not stay heresy; The Radix Astragali is joined Poria cocos, and all deficiency of vital energy persons with the about the whole body of mediator's body surface are good at strengthening the spleen and replenishing qi especially, for controlling deficiency of vital energy lassitude hypodynamia key medicine, also are traditional qi-invigorating herbs.The chrysanthemum wind-dispelling heat-dissipating is with the heresy of the wind-heat of Xie Zaibiao; Honeysuckle is clearing heat and detoxicating, and assistant is dispelled rheumatism with the root of Dahurain angelica; The golden cypress killing parasites to relieve itshing is taken the coptis, the root of large-flowered skullcap, the logical fire that rushes down three warmers of cape jasmine, and heat conduction is descending, is combined into the clearing heat and detoxicating merit of purging intense heat.The wilsonii general glycoside of the non-starchiness polysaccharide of the Radix Astragali, wilsonii plays an important role at the raising immunology in addition, also multiple tired animal model is all had antifatigue, anti-inflammatory, anti-ageing many-sided effect of waiting for a long time.
In addition,, fight outward because of ailment said due to cold or exposure again, or water loses the fire institute that stagnates and stagnates, also can cause all sores of freckle by the strongly fragrant grandson's network of fire. in control with purging intense heat and detonicating, benefiting qi and nourishing blood is to manage; Controlling outward should be with dispelling wind pathogens, and dispersing stagnated fire is method. and be to be so incensed that Wen Zehang, blood gets Wen Zesheng. and the present invention increases in the health composition preparation of immunity, the sweet thoughts of returning home warp of pearl, mental-tranquilization; The sweet hot nourishing the liver of Radix Angelicae Sinensis and give birth to painstaking effort is the product of nourshing blood and promoting blood circulation, use can with the blood myogenic, the skin moisten pain relieving is the good merchantable brand of regenerating tissue to heal wond; Safflower suffering and the medicine of sweetness and bitterness temperature Liver Channel blood system, promoting blood circulation has the merit of removing pattogenic heat from the blood and toxic material from the body again concurrently, wine is good, can improve lymphocytic conversion ratio; Dragon's blood is the fat liquid of wood, as people's human fat and blood, for the panacea of blood, the two all walks blood system Radix Angelicae Sinensis and dragon's blood, and the root of Dahurain angelica can " longue skin, moist color; can make face fat ", with the suffering temperature of the root of Dahurain angelica, moisten gas with and blood, and Radix Angelicae Sinensis gets the root of Dahurain angelica, and the power that nourishes blood increases, and the root of Dahurain angelica gets Radix Angelicae Sinensis, especially can live pain by skin moisten, Asian puccoon is clearing heat and detoxicating, and hygroscopic is held back sore, help dragon's blood to remove necrotic tissue and promoting muscle growing. the hot dissipating bind of mung bean flour, the Chinese honey locust skin moisten closes face, windproof exploitation and can loose general for controlling wind; Jehol Ligusticum Rhizome is evacuated outer evil, and the hot fragrant row of Kaempferia galanga looses, and is capable to help blood. and all medicines match, and outer ailment said due to cold or exposure of fighting must be loose, interior strongly fragrant fiery must sending out, skin moisten supports, and can show the youth to reside.
The present invention increases in the health composition preparation of immunity, collects cloves, storax, purlin perfume (or spice), agalloch eaglewood, the banksia rose, rhizoma cyperi, wrinkled giant hyssop, styrax, smokes incense drugs such as Lu Xiang in a stove, focuses on tourette production of aromatic, the inducing resuscitation of having one's ideas straightened out; Various active such as Radix Glycyrrhizae is sweet flat, and contained enoxolone has the effect of cortex hormone of aadrenaline sample, anti-inflammatory is arranged, antitumor; The slow pain of Chinese wax myogenic, and make excipient, all medicines share, play altogether dispel rheumatism, clearing heat and detoxicating, antibacterial desinsection, resuscitation with aromatics, the effect of corruption, the clean skin of lustrous and transparent flesh of dispelling of invigorating blood circulation.Having is that outer ailment said due to cold or exposure of fighting must be loose, interior strongly fragrant fiery must sending out, and residual poison must be separated, its fire poison descends then all disease self-balancing.This, described " universe not to be easily to know, and is female with simple energy as " easily pass ".Yi Zeyi knows, general regulations easily from.……。Easily letter and the world manages.”
The health composition that the present invention increases immunity adds flavor according to " danxi's experiential therapy " Yupingfeng San, has both preserved the marrow place of ancient prescription, has expanded its actual effect application in the modern life again.The health composition that strengthens immunity by the present invention is the contribution effect of human body, allow people therefrom the present invention strengthen in the health composition of immunity and obtain active principles such as polysaccharide, improve cytophagous function, strengthen self body immunity to reach, unreally be a kind of immunity, favourable anti-ageing good recipe of prolonging the health care of going forward side by side of declining of reasonably, effectively strengthening disease.
Description of drawings
Fig. 1 is the preparation process flow chart of the present invention's health composition of increasing immunity.
Activity experiment
The present invention increases the health composition of immunity to the comparative study of immune function of mice impact.
1, experiment material:
(1) composition of the present invention
(2) BALB/C mice (male)
(3) sheep red blood cell
(4) mouse cytokine detection kit
2, experimental technique:
(1) Balb/c mouse (female) is divided into groups by following scheme, 7 every group, stomach was raised mouse in continuous 15 days, and preparation consumption of the present invention is by the mouse weighing scale.
A. physiological saline group 0.1ml/ only
B. present composition given the test agent group (hereinafter to be referred as the test sample group) 5mg/kg 0.125mg/ only
Stomach was raised mouse in continuous 20 days, and the consumption of the present composition is by the mouse weighing scale.
(2) mensuration of serum hemolysin content
After stomach is raised 10 days, injection 2% sheep red blood cell (SRBC) 0.2ml in every mouse peritoneal, and continue stomach and raise to 15 days; Get mouse orbit blood, centrifugal rear collection serum. after getting 64 times of serum dilutions, add in the 96 hole circle base plates, and add successively 2%SRBC, the fresh GPC of dilution in 1: 8, and establish increase serum not and do not add the blank pipe of complement, put be incubated 15~30min in 37 ℃ of waters bath with thermostatic control after, sentence control tube in 540nm and make blank, the OD value when mensuration is respectively managed OD value .SRBC HD50 respectively is the OD value after 1ml 2%SRBC is dissolved in 7ml distilled water.
The amount of hemolysin is with HD50 value (HC50) expression, calculate the HC of given the test agent group by following formula50Be significantly higher than the HC of control group50, can judge this experimental result positive.
Figure G2009102124084D0000061
(3) mouse NK killing ability detects (LDH method for releasing)
The endochylema of living cells contains LDH. Under normal circumstances, LDH can not permeate through cell membranes, and after cell was subject to killing and wounding of NK cell, LDH was discharged into the extracellular. LDH can make the lithium lactate dehydrogenation, and then makes NAD be reduced into NADH, and through hydrogen carrier PMS (PMS) reduction p-Iodonitrotetrazolium violet (INT), INT accepts H-and is reduced into aubergine formazan compounds the latter again. In ELIASA 490nm colorimetric estimation.
Mouse boosting cell suspension (5 * 106/ ml) add in the 96 porocyte culture plates 100 μ l/ holes. The YAC-1 target cell that subculture in vitro separately is cultivated is centrifugal, adjusts cell concentration 1 * 105/ ml. 100 μ l/ holes, 1 * 104/ porocyte. Put 37 ℃, 5%CO2Incubator is cultivated 4h, and establishes Spontaneous release and maximum release group as the yin and yang attribute contrast of experiment. Centrifugal 1000r/min, 5min. Draw supernatant 100 μ l, add LDH substrate solution 100 μ l, leave standstill 3min. Adding subsequently 1NHCL ends. Measure OD value (OD) at ELIASA 490nm place. Calculate the percentage that kills and wounds of NK cell.
Figure G2009102124084D0000071
(4) detection of mouse cytokine
Eyeball of mouse is got blood, and room temperature is placed, centrifugal acquisition mice serum; Collect spleen cell through post-stimulatory cells and supernatant, measure respectively different cell factors according to cytokines measurement kit operating instruction.
3, experimental result:
Table 1: the mensuration of serum hemolysin content
Group Mean value Standard deviation P value *
The physiological saline group   92.54   8.92
The test sample group   112.34   16.48   0.0083
Table 2: on the impact of T cell subsets
Group   L3T4(CD4)   Lyt2(CD8)
Normal group (NS)   42.00±4.81   15.11±5.24
Preparation of the present invention   37.59±2.09   15.17±8.08
Table 3: on the impact of Function of lymphocyte transform
Group SI mean value The SI standard deviation   RR
Normal group   14.29   1.23   100.3
The test sample group   16.98   3.53   118.0
Table 4: on the impact of NK cell killing function
Group Killing activity (50: 1) %
Normal group   16.4±9.3
The test sample group   20.6±2.3
Table 5: on the impact of cell factor generation
Group   IL-4   INF -γ   IL-6   TNF-α
Normal group   18.1±3.4   902.6±305.7   70.5±37.3   5.5±1.5
The test sample group   16.6±9.2   1512.2±251.4   272.8±82.2   5.8±2.3
Experimental result shows: within the specific limits, the NK cytoactive is directly proportional with effect target ratio. Calculate the NK cytoactive by above-mentioned formula, the NK cytoactive of present composition given the test agent group is significantly higher than the NK cytoactive of control group, can judge this experimental result positive. To the immunoregulation effect of mouse mainly to more obvious take T cell and NK cell as main immunization of cell.
The present invention increases the health composition given the test agent group of immunity, not only immunosuppressive effect is had antagonism, has simultaneously the forward immunoregulation effect, can improve the immunologic function of mouse body.
The selection of imvite
China finds that there are two places in the place of production of attapulgite: one in Shanxi large recessed mountain one band, relevant with cretaceous volcanic rock; One six directions in Jiangsu and Anhui two provinces boundary, a day long band, the basalt that erupts during with Miocene Epoch to the Pliocene Epoch is relevant. The clay pit in area, Luhe can be divided into four kinds of ore type, namely attapulgite be stained with, montmorillonitic clay, hydromica Concave-convex clay rod and dolomite Concave-convex clay rod. Montmorillonitic clay, be by tufa stone or volcanic rock under the effect of seawater or underground water, through after the long-term chemical weathering, deposition forms in alkaline medium (pH=7~8.5) environment. A kind of moisture layer aluminosilicate mineral, tool dispersion suspension, caking property, melt sex change, lubricity, plasticity and good adsorptivity.
The present invention increases in the health composition and preparation method of immunity, selects imvite and Jiangning phreatic water in six directions bamboo town, Nanjing. Select exactly imvite to have special physicochemical properties, the Buddhist monk is contained multiple to people, constant or trace element that animal bodies is useful, to promote to improve health.
Get Nanjing six directions bamboo town imvite, analyze with XR (f) S according to JY/T016-1996, the result is as follows for its analyzing and testing:
Measurement unit: wt%ppm
??Al2O3 ??CaO ??Fe2O3 ??K2O ??MgO ??MnO ??Na2O ??P2O5 ??SiO2 ??TiO2
Imvite ??15.16 ??1.26 ??7.82 ??1.41 ??3.48 ??0.05 ??0.13 ??0.04 ??58.06 ??1.14
??Rb ??Sr ??y ??Zr ??Nb ??U ??Th ??Pb ??Mo ??As
Imvite ??78 ??78 ??16 ??178 ??21 ??1 ??9 ??9 ??4 ??8
??Zn ??Ni ??Sb ??Ga ??Co ??Cr ??V ??Ba ??Hf ??Cu
Imvite ??91 ??54 ??6 ??18 ??12 ??130 ??120 ??245 ??6 ??48
Get Jiangning phreatic water, analyze according to GB/T5750-2006, the result is as follows for its analyzing and testing:
Measurement unit: mg/l
Measured value ??Al ??Cd ??CaCO3 ??Cd ??Hg ??Cr ??Cu ??Mn
Phreatic water ??<0.001 ??<0.0001 ??135.3 ??<0.003 ??<0.0002 ??<0.004 ??0.001 ??0.011
Measured value ??As ??Pb ??Si ??Sr ??Zn ??Fe ??Se ??PH
Phreatic water ??<0.06 ??0.002 ??7.04 ??0.21 ??0.025 ??0.08 ??<0.005 ??7.78
Experimental result:
The present invention increases the health composition of immunity, selected Nanjing six directions bamboo town imvite and Jiangning phreatic water, contain a large amount of mineral matters, various trace elements, reach rare earth element, as alkalinous metal Rb and constant and elements such as trace elements zn, Cu etc., rare earth yttrium.Rare earth element has the character of similar trace element, and it has the 4f electron structure of underfill, and produces diversified electron energy level therefrom; The metal activity is only second to alkali metal and alkali earth metal, and more active than other metallic elements.The present invention is exactly with its very active biochemical property; in preparation of the present invention, play catalyst (activation body); fully show the present invention and increase pharmaceutically active substance in the health composition of immunity; allow as the mode of vitamin with coenzyme; participate in the work of ferment catalytic reaction; impel the physiological function activity acceleration of being gone in the body, promote immunity with the vigor that improves human body.
The specific embodiment
Pharmacology composition of prescription and corresponding part by weight by science increase or reduce, and can obtain the health composition sieve side that multiple the present invention increases immunity.
(1) embodiment 1, get:
20~120 parts of 10~120 parts of roots of Dahurain angelica of 20~90 parts of Poria cocos of 20~120 portions of fruits of Chinese wolfberry of cloves
20~120 parts of 20~120 portions of honeysuckles of 20~90 portions of wrinkled giant hyssops of 20~90 parts of orange peels of cape jasmine
50~360 parts of 20~120 parts of honey of 20~120 portions of roses of 20~120 portions of cordate houttuynias of Radix Glycyrrhizae
10~60 parts of 50~360 parts of pearls of 50~360 parts of sesame oil of 50~360 parts of glutinous rice of mung bean
20~90 parts of 10~90 parts of rhodiola roots of 30~180 parts of safflowers of 50~360 parts of Radix Angelicae Sinensis of suet
30~180 parts of 10~60 parts of Radixs Astragali of 10~60 parts of windproof 10~60 parts of bighead atractylodes rhizomes of rhizoma cyperi
10~60 parts of 10~90 portions of Asian puccoons of 10~60 parts of dragon's blood of 10~60 parts of banksia rose of agalloch eaglewood
Styrax smokes 0.2~20 part of 10~60 parts of imvite of 10~60 portions of Chinese honey locusts of Lu Xiang for 10~60 parts
10~90 parts of Chinese wax
The above-mentioned raw materials medicinal material is processed as follows:
The first step: get each raw medicinal material by prescription;
Second step: respectively raw medicinal material rhodiola root, safflower, the fruit of Chinese wolfberry are carried out vacuum drying, be lower than 10% to water content;
The 3rd step: the rhodiola root after the vacuum drying, safflower, fruit of Chinese wolfberry raw medicinal material were added 5~15 times of weight 42~65% liquor dippings respectively 10~40 hours, filtration residue adds 5~15 times of weight 42~65% liquor dippings again, continuous backflow 2~3 times, each 1~5 hour, merge extract and concentrate, dry, pulverized 160 mesh sieves;
The 4th step: all the other medicinal materials are with pulverizing 160 mesh sieves through rhodiola root, safflower, fruit of Chinese wolfberry residue behind 42~65% liquor dipping in will filling a prescription;
The 5th step: will soak after the imvite coarse crushing 24~72 hours, filter and to add water and reflux 2~3 times, the time 1~5 hour, merge maceration extract and reflux extracting liquid to concentrate, dry, pulverized 160 mesh sieves;
The 6th step: earlier with raw medicinal materials such as Radix Angelicae Sinensis, Radix Glycyrrhizae, Asian puccoon, the roots of Dahurain angelica, went into spunyarn oil three, slow fire little withered look of torturing in the big spoon, thin thin,tough silk filtering in oily reentrant spoon, is fried in shallow oil and is rolled down whole dragon's bloodization to the greatest extent;
The 7th step: inferior down suet, Chinese wax (can add as external application, take and needn't add), low baking temperatureization it; A moment is waited in cooling to be cooled, grinds superfine pearl powder under the side, stirs evenly, and waits and has got to one day.
(2) embodiment 2, get:
20~120 parts of 20~90 portions of peppermints of 20~120 portions of fruits of Chinese wolfberry of 20~120 portions of dark plums of cloves
Real 20~120 parts of 10~120 portions of Chinese scholartrees of 20~120 parts of orange 20~90 parts of Poria cocos of the root of Dahurain angelica
20~120 parts of 20~120 portions of honeysuckles of 20~90 portions of fruits of Chinese wolfberry of 20~120 parts of orange peels of mulberry leaf
20~120 parts of 20~120 parts of chrysanthemums of 20~120 portions of wrinkled giant hyssops of 20~120 portions of Radix Glycyrrhizaes of bitter orange flower
50~360 parts in 50~360 parts of glutinous rice of 20~120 portions of mung beans of 20~120 portions of cordate houttuynias of rose
50~360 parts in 50~360 parts of sesame oil of 20~120 parts of honey of 20~90 portions of wrinkled giant hyssops of cape jasmine
20~90 parts of 10~60 parts of rhodiola roots of 10~60 portions of golden cypresses of 50~360 parts of roots of large-flowered skullcap of olive oil
30~180 parts of 10~60 parts of Radixs Astragali of 10~60 portions of coptiss of windproof 10~60 parts of bighead atractylodes rhizomes
10~60 parts of 10~60 parts of pearls of 10~60 parts of storaxs of 10~60 parts of purlin perfume (or spice) of Kaempferia galanga
30~180 parts of 10~60 parts of Radix Angelicae Sinensis of 10~90 portions of rhizoma cyperis of 10~60 parts of safflowers of moutan bark
10~60 parts of 10~90 portions of Asian puccoons of 10~60 parts of dragon's blood of 10~60 parts of banksia rose of agalloch eaglewood
Styrax smokes 10~60 parts of 50~360 parts of Jehol Ligusticum Rhizomes of 10~60 parts of suet of Lu Xiang for 10~60 parts
0.2~20 part of 10~90 parts of imvite of 10~60 parts of Chinese wax of 10~60 portions of Chinese honey locusts of wilsonii
The above-mentioned raw materials medicinal material is processed as follows:
The first step: get each raw medicinal material by prescription;
Second step: respectively raw medicinal material rhodiola root, safflower, the fruit of Chinese wolfberry are carried out vacuum drying, be lower than 10% to water content;
The 3rd step: the rhodiola root after the vacuum drying, safflower, fruit of Chinese wolfberry raw medicinal material were added 5~15 times of weight 42~65% liquor dippings respectively 10~40 hours, filtration residue adds 5~15 times of weight 42~65% liquor dippings again, continuous backflow 2~3 times, each 1~5 hour, merge extract and concentrate, dry, pulverized 160 mesh sieves;
The 4th step: all the other medicinal materials are with pulverizing 160 mesh sieves through rhodiola root, safflower, fruit of Chinese wolfberry residue behind 42~65% liquor dipping in will filling a prescription;
The 5th step: will soak after the imvite coarse crushing 24~72 hours, filter and to add water and reflux 2~3 times, the time 1~5 hour, merge maceration extract and reflux extracting liquid to concentrate, dry, pulverized 160 mesh sieves;
The 6th step: earlier with raw medicinal materials such as Radix Angelicae Sinensis, Radix Glycyrrhizae, Asian puccoon, the roots of Dahurain angelica, went into olive oil three, slow fire little withered look of torturing in the big spoon, thin thin,tough silk filtering in oily reentrant spoon, is fried in shallow oil and is rolled down whole dragon's bloodization to the greatest extent;
The 7th step: inferior down suet, Chinese wax (can add as external application, take and needn't add), low baking temperatureization it; A moment is waited in cooling to be cooled, grinds superfine pearl powder under the side, stirs evenly, and waits and has got to one day.
(3) embodiment 3, get:
10~120 parts in 20~120 parts of Poria cocos of real 20~120 portions of fruits of Chinese wolfberry of 20~120 portions of Chinese scholartrees of the root of Dahurain angelica
30~180 parts of 10~60 parts of Radixs Astragali of 10~60 portions of coptiss of windproof 10~60 parts of bighead atractylodes rhizomes
20~120 parts of 10~60 parts of chrysanthemums of 10~60 portions of golden cypresses of 20~90 parts of roots of large-flowered skullcap of cape jasmine
30~180 parts of 20~120 parts of Radix Angelicae Sinensis of 20~120 portions of Radix Glycyrrhizaes of orange 20~90 parts of mulberry leaf
20~120 parts of 20~120 portions of wrinkled giant hyssops of 10~90 portions of bitter orange flowers of 10~60 parts of dragon's blood of purlin perfume (or spice)
50~360 parts in 50~360 parts of olive oil of 10~60 parts of honey of 20~90 parts of pearls of rhodiola root
0.2~20 part of 50~360 parts of imvite of 50~360 parts of suet of 50~360 parts of glutinous rice of mung bean
10~90 parts of Chinese wax
The above-mentioned raw materials medicinal material is processed as follows:
The first step: get each raw medicinal material by prescription;
Second step: respectively raw medicinal material rhodiola root, the fruit of Chinese wolfberry are carried out vacuum drying, be lower than 10% to water content;
The 3rd step: the rhodiola root after the vacuum drying, fruit of Chinese wolfberry raw medicinal material were added 5~15 times of weight 42~65% liquor dippings respectively 10~40 hours, filtration residue adds 5~15 times of weight 42~65% liquor dippings again, continuous backflow 2~3 times, each 1~5 hour, merge extract and concentrate, dry, pulverized 160 mesh sieves;
The 4th step: all the other medicinal materials are with pulverizing 160 mesh sieves through rhodiola root, fruit of Chinese wolfberry residue behind 42~65% liquor dipping in will filling a prescription;
The 5th step: will soak after the imvite coarse crushing 24~72 hours, filter and to add water and reflux 2~3 times, the time 1~5 hour, merge maceration extract and reflux extracting liquid and concentrate, dry, pulverized 160 mesh sieves:
The 6th step: earlier, go into olive oil with raw medicinal materials such as Radix Angelicae Sinensis, Radix Glycyrrhizae, the roots of Dahurain angelica, slow fire little withered look of torturing in the big spoon, thin thin,tough silk filtering in oily reentrant spoon, is fried in shallow oil and is rolled down whole dragon's bloodization to the greatest extent;
The 7th step: inferior down suet, Chinese wax (can add as external application, take and needn't add), low baking temperatureization it; A moment is waited in cooling to be cooled, grinds superfine pearl powder under the side, stirs evenly, and waits and has got to one day.
(4) embodiment 4, get:
20~120 parts of 20~120 parts of roots of Dahurain angelica of 20~90 portions of peppermints of 20~120 portions of fruits of Chinese wolfberry of dark plum
10~120 parts in 20~120 parts of Poria cocos of 20~120 portions of bitter orange flowers of 20~90 portions of fruits of Chinese wolfberry of orange peel
20~90 parts of 20~120 parts of rhodiola roots of 20~120 parts of chrysanthemums of 20~120 portions of wrinkled giant hyssops of Radix Glycyrrhizae
30~180 parts of 10~60 parts of Radixs Astragali of 10~60 parts of windproof 10~60 parts of bighead atractylodes rhizomes of Kaempferia galanga
30~180 parts of 10~60 parts of Radix Angelicae Sinensis of 10~90 portions of rhizoma cyperis of 10~60 parts of safflowers of moutan bark
10~60 parts of 10~90 portions of Asian puccoons of 10~60 parts of dragon's blood of 10~60 parts of banksia rose of agalloch eaglewood
50~360 parts in 50~360 parts of olive oil of 20~120 parts of honey of 20~90 portions of wrinkled giant hyssops of cape jasmine
50~360 parts in 50~360 parts of olive oil of 50~360 parts of glutinous rice of 20~120 portions of mung beans of cordate houttuynia
0.2~20 part of 50~360 parts of imvite of 20~120 parts of suet of 10~60 portions of cloves of pearl
10~90 parts of Chinese wax
The above-mentioned raw materials medicinal material is processed as follows:
The first step: get each raw medicinal material by prescription;
Second step: respectively raw medicinal material rhodiola root, the fruit of Chinese wolfberry are carried out vacuum drying, be lower than 10% to water content;
The 3rd step: the rhodiola root after the vacuum drying, fruit of Chinese wolfberry raw medicinal material were added 5~15 times of weight 42~65% liquor dippings respectively 10~40 hours, filtration residue adds 5~15 times of weight 42~65% liquor dippings again, continuous backflow 2~3 times, each 1~5 hour, merge extract and concentrate, dry, pulverized 160 mesh sieves;
The 4th step: all the other medicinal materials are with pulverizing 160 mesh sieves through rhodiola root, fruit of Chinese wolfberry residue behind 42~65% liquor dipping in will filling a prescription;
The 5th step: will soak after the imvite coarse crushing 24~72 hours, filter and to add water and reflux 2~3 times, the time 1~5 hour, merge maceration extract and reflux extracting liquid to concentrate, dry, pulverized 160 mesh sieves;
The 6th step: earlier with raw medicinal materials such as Radix Angelicae Sinensis, Radix Glycyrrhizae, the roots of Dahurain angelica, went into olive oil three, slow fire little withered look of torturing in the big spoon, thin thin,tough silk filtering in oily reentrant spoon, is fried in shallow oil and is rolled down whole dragon's bloodization to the greatest extent;
The 7th step: inferior down suet, Chinese wax (can add as external application, take and needn't add), low baking temperatureization it; A moment is waited in cooling to be cooled, grinds superfine pearl powder under the side, stirs evenly, and waits and has got to one day.
(5) embodiment 5, get:
20~120 parts of 10~120 parts of roots of Dahurain angelica of 20~90 parts of Poria cocos of 20~120 portions of fruits of Chinese wolfberry of cloves
20~120 parts of 20~120 parts of chrysanthemums of 20~90 portions of wrinkled giant hyssops of 20~90 parts of orange peels of cape jasmine
50~360 parts of 20~120 parts of honey of 10~60 portions of roses of 20~120 parts of wilsoniis of Radix Glycyrrhizae
10~60 parts of 50~360 parts of pearls of 50~360 parts of sesame oil of 50~360 parts of glutinous rice of mung bean
20~90 parts of 10~90 parts of rhodiola roots of 30~180 parts of safflowers of 50~360 parts of Radix Angelicae Sinensis of suet
30~180 parts of 10~60 parts of Radixs Astragali of 10~60 parts of windproof 10~60 parts of bighead atractylodes rhizomes of rhizoma cyperi
10~60 parts of 10~90 portions of Asian puccoons of 10~60 parts of dragon's blood of 10~60 parts of banksia rose of agalloch eaglewood
Styrax smokes 10~60 parts of 10~60 parts of Jehol Ligusticum Rhizomes of 10~60 portions of Chinese honey locusts of Lu Xiang for 10~60 parts
0.2~20 part of 10~90 parts of imvite of Chinese wax
The above-mentioned raw materials medicinal material is processed as follows:
The first step: get each raw medicinal material by prescription;
Second step: respectively raw medicinal material rhodiola root, safflower, the fruit of Chinese wolfberry are carried out vacuum drying, be lower than 10% to water content;
The 3rd step: the rhodiola root after the vacuum drying, safflower, fruit of Chinese wolfberry raw medicinal material were added 5~15 times of weight 42~65% liquor dippings respectively 10~40 hours, filtration residue adds 5~15 times of weight 42~65% liquor dippings again, continuous backflow 2~3 times, each 1~5 hour, merge extract and concentrate, dry, pulverized 160 mesh sieves;
The 4th step: all the other medicinal materials are with pulverizing 160 mesh sieves through rhodiola root, safflower, fruit of Chinese wolfberry residue behind 42~65% liquor dipping in will filling a prescription;
The 5th step: will soak after the imvite coarse crushing 24~72 hours, filter and to add water and reflux 2~3 times, the time 1~5 hour, merge maceration extract and reflux extracting liquid to concentrate, dry, pulverized 160 mesh sieves;
The 6th step: earlier with raw medicinal materials such as Radix Angelicae Sinensis, Radix Glycyrrhizae, Asian puccoon, the roots of Dahurain angelica, went into spunyarn oil three, slow fire little withered look of torturing in the big spoon, thin thin,tough silk filtering in oily reentrant spoon, is fried in shallow oil and is rolled down whole dragon's bloodization to the greatest extent;
The 7th step: inferior down suet, Chinese wax (can add as external application, take and needn't add), low baking temperatureization it; A moment is waited in cooling to be cooled, grinds superfine pearl powder under the side, stirs evenly, and waits and has got to one day.

Claims (5)

1. health composition that strengthens immunity, make by following bulk drugs:
20~120 parts of 10~120 parts of roots of Dahurain angelica of 20~90 parts of Poria cocos of 20~120 portions of fruits of Chinese wolfberry of cloves
20~120 parts of 20~120 portions of honeysuckles of 20~90 portions of wrinkled giant hyssops of 20~90 parts of orange peels of cape jasmine
50~360 parts of 20~120 parts of honey of 20~120 portions of roses of 20~120 portions of cordate houttuynias of Radix Glycyrrhizae
10~60 parts of 50~360 parts of pearls of 50~360 parts of sesame oil of 50~360 parts of glutinous rice of mung bean
20~90 parts of 10~90 parts of rhodiola roots of 30~180 parts of safflowers of 50~360 parts of Radix Angelicae Sinensis of suet
30~180 parts of 10~60 parts of Radixs Astragali of 10~60 parts of windproof 10~60 parts of bighead atractylodes rhizomes of rhizoma cyperi
10~60 parts of 10~90 portions of Asian puccoons of 10~60 parts of dragon's blood of 10~60 parts of banksia rose of agalloch eaglewood
Styrax smokes 10~60 parts of illiteracies of 10~60 portions of Chinese honey locusts of Lu Xiang for 10~60 parts and takes off 0.2~20 part
10~90 parts of Chinese wax.
2. the health composition of enhancing immunity according to claim 1, make by following bulk drugs:
20~120 parts of 20~90 portions of peppermints of 20~120 portions of fruits of Chinese wolfberry of 20~120 portions of dark plums of cloves
Real 20~120 parts of 10~120 portions of Chinese scholartrees of 20~120 parts of orange 20~90 parts of Poria cocos of the root of Dahurain angelica
20~120 parts of 20~120 portions of honeysuckles of 20~90 portions of fruits of Chinese wolfberry of 20~120 parts of orange peels of mulberry leaf
20~120 parts of 20~120 parts of chrysanthemums of 20~120 portions of wrinkled giant hyssops of 20~120 portions of Radix Glycyrrhizaes of bitter orange flower
50~360 parts in 50~360 parts of glutinous rice of 20~120 portions of mung beans of 20~120 portions of cordate houttuynias of rose
50~360 parts in 50~360 parts of sesame oil of 20~120 parts of honey of 20~90 portions of wrinkled giant hyssops of cape jasmine
20~90 parts of 10~60 parts of rhodiola roots of 10~60 portions of golden cypresses of 50~360 parts of roots of large-flowered skullcap of olive oil
30~180 parts of 10~60 parts of Radixs Astragali of 10~60 portions of coptiss of windproof 10~60 parts of bighead atractylodes rhizomes
10~60 parts of 10~60 parts of pearls of 10~60 parts of storaxs of 10~60 parts of purlin perfume (or spice) of Kaempferia galanga
30~180 parts of 10~60 parts of Radix Angelicae Sinensis of 10~90 portions of rhizoma cyperis of 10~60 parts of safflowers of moutan bark
10~60 parts of 10~90 portions of Asian puccoons of 10~60 parts of dragon's blood of 10~60 parts of banksia rose of agalloch eaglewood
Styrax smokes 10~60 parts of 50~360 parts of Jehol Ligusticum Rhizomes of 10~60 parts of suet of Lu Xiang for 10~60 parts
0.2~20 part of 10~90 parts of imvite of 10~60 parts of Chinese wax of 10~60 portions of Chinese honey locusts of wilsonii.
3. according to the health composition of claim 1, it is characterized in that its formulation is the formulation that allows on any pharmacy.
4. according to the health composition of claim 3, it is characterized in that described formulation is capsule, tablet, granule, pill, powder, sublimed preparation, pill, paste, fat agent or creme.
5. the preparation method of claim 1 or 2 described health compositions is characterized in that this method comprises the steps:
The first step: get each raw medicinal material by prescription;
Second step: respectively raw medicinal material rhodiola root, safflower are carried out vacuum drying, be lower than 10% to water content;
The 3rd step: the rhodiola root after the vacuum drying, safflower raw medicinal material were added 5~15 times of weight 42~65% liquor dippings respectively 10~40 hours, filtration residue adds 5~15 times of weight 42~65% liquor dippings again, continuous backflow 2~3 times, each 1~5 hour, merge extract and concentrate, dry, pulverized 160 mesh sieves;
The 4th step: all the other medicinal materials are with pulverizing 160 mesh sieves through rhodiola root, safflower residue behind 42~65% liquor dipping in will filling a prescription;
The 5th step: soaked 24~72 hours after illiteracy taken off coarse crushing, filter and add water and reflux 2~3 times, the time 1~5 hour, merging maceration extract and reflux extracting liquid concentrated, dry, pulverized 160 mesh sieves;
The 6th step: earlier, went into oil (sesame oil, olive oil) three with raw medicinal materials such as Radix Angelicae Sinensis, Radix Glycyrrhizae, Asian puccoon, the roots of Dahurain angelica, slow fire little withered look of torturing in the big spoon, thin thin,tough silk filtering in oily reentrant spoon, is fried in shallow oil and is rolled down whole dragon's bloodization to the greatest extent;
The 7th step: inferior down suet, Chinese wax (can add as external application, take and needn't add), low baking temperatureization it; A moment is waited in cooling to be cooled, grinds superfine pearl powder under the side, stirs evenly, and waits and has got to one day.
CN200910212408A 2009-11-10 2009-11-10 Health-care composition for strengthening immunity and preparation method thereof Pending CN101703228A (en)

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Cited By (7)

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Publication number Priority date Publication date Assignee Title
CN102396628A (en) * 2011-11-05 2012-04-04 安徽省天旭茶业有限公司 Heat-clearing and detoxifying health-care Chinese herbal tea and preparation method thereof
CN102911812A (en) * 2012-11-02 2013-02-06 李旻 Materia medica medicated soap composition and preparation method thereof
CN103168883A (en) * 2012-09-24 2013-06-26 甘肃创兴生物工程有限责任公司 Pathogenic microorganism preventing antiviral tea beverage granules capable of boosting immunity and preparation method thereof
CN104293621A (en) * 2014-10-11 2015-01-21 李文霞 Selenium-enriched health rice wine and preparation method thereof
CN106213514A (en) * 2016-08-02 2016-12-14 马佳 A kind of chrysanthemum health-care oral liquid improving immunity and preparation method thereof
CN106360544A (en) * 2016-08-25 2017-02-01 明光市昊昊蜂业有限公司 Cooling and internal-heat-relieving honey composition
CN106418529A (en) * 2016-08-02 2017-02-22 马佳 Preparation method of chrysanthemum oral liquid capable of improving immunity and oral liquid thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102396628A (en) * 2011-11-05 2012-04-04 安徽省天旭茶业有限公司 Heat-clearing and detoxifying health-care Chinese herbal tea and preparation method thereof
CN103168883A (en) * 2012-09-24 2013-06-26 甘肃创兴生物工程有限责任公司 Pathogenic microorganism preventing antiviral tea beverage granules capable of boosting immunity and preparation method thereof
CN102911812A (en) * 2012-11-02 2013-02-06 李旻 Materia medica medicated soap composition and preparation method thereof
CN104293621A (en) * 2014-10-11 2015-01-21 李文霞 Selenium-enriched health rice wine and preparation method thereof
CN104293621B (en) * 2014-10-11 2016-03-02 李文霞 A kind of selenium-enriched health care rice wine and preparation method thereof
CN106213514A (en) * 2016-08-02 2016-12-14 马佳 A kind of chrysanthemum health-care oral liquid improving immunity and preparation method thereof
CN106418529A (en) * 2016-08-02 2017-02-22 马佳 Preparation method of chrysanthemum oral liquid capable of improving immunity and oral liquid thereof
CN106360544A (en) * 2016-08-25 2017-02-01 明光市昊昊蜂业有限公司 Cooling and internal-heat-relieving honey composition

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Application publication date: 20100512