CN105327302A

CN105327302A - Pharmaceutical composition for regulating yin-yang and qi and blood to treat tumors and preparation method of pharmaceutical composition

Info

Publication number: CN105327302A
Application number: CN201410386028.3A
Authority: CN
Inventors: 王长林
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-08-07
Filing date: 2014-08-07
Publication date: 2016-02-17

Abstract

The invention discloses a pharmaceutical composition for regulating yin-yang and qi and blood to treat tumors and a preparation method of the pharmaceutical composition. The formulation is formed by the compatibility of Chinese herbal materials such as Cortex Cinnamomi, Rhizoma Dioscoreae, Poria, rhizoma Atractylodis Macrocephalae and Radix Angelicae Sinensis. The formulation has the effects such as tonifying yin and yang, tonifying qi and blood, eliminating dampness and heat, and regulating qi activity. It is clinically proved that the formulation treats both symptoms and root causes, takes a short treatment course, acts fast, is suitable for conditioning insufficient anti-pathogenic energy caused by the injury of qi, blood, yin and yang due to disease progression and conditioning anti-pathogenic energy after surgery or chemo-radiotherapy.

Description

Drug regimen of one group of coordinating YIN and YANG QI and blood treatment tumor and preparation method thereof

Technical field

The present invention relates to compatibility of drugs combination of one group of coordinating YIN and YANG QI and blood treatment tumor and preparation method thereof, be specifically the compatibility of drugs combination of raw material and the Chinese medicine preparation of preparation with Chinese crude drug, belong to Chinese materia medica field.

Background technology

Tumor be body various cause tumor diathesis effect under, the cellular abnormality hypertrophy of local organization and the neoplasm that formed, often show as local lump.Tumor cell is different from the cell of normal structure, and it grows not according to Normocellular metabolism rule, and becomes unfettered and control, and causes cell to present abnormal form, function and metabolism, so that destroy the structure of normal structure organ and affect its function.Growth of tumour cell is vigorous, the normal growth in persistence.The traditional traditional Chinese medical science of China thinks that tumor is a kind of disease belonging to general, and tumor is divided into the optimum and large class of malignant tumor two, and common sign is weak, and body is empty, appetite is poor, lose weight than comparatively fast, and according to different phase with heating and pain.Benign tumor poor growth, with surrounding tissue boundary clear, does not shift, little to human health damage.Malignant growth is rapid, can be transferred to other position of health, also can produce harmful substance, destroys normal organ structure, body function is lacked of proper care, life-threatening.

The pathogenesis of tumor, the traditional Chinese medical science is thought: condense with the vital QI being weakened and pathogen being violent of human body, qi depression to blood stasis, zang-fu disharmony, phlegm-damp, the internal and external factor such as scorchingly hot interior knot is relevant.

For the pathogenesis of tumor, the present invention instructs, and adopt nourishing YIN sun, replenishing QI and blood, eliminating damp-heat, the methods such as regulating functional activities of qi, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, reaches desirable therapeutic effect.

Clinical proof, this serial prescription treating both the principal and secondary aspects of a disease, short treating period, instant effect, be applicable to this disease progression, injures negative and positive of qi and blood and the positive QI-insufficiency that causes, and after operation or chemicotherapy, the tune of healthy energy is multiple.

Summary of the invention

The present invention, in order to treat breast nodule, the invention provides to form with the compatibility of Cortex Cinnamomi, Rhizoma Dioscoreae, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis etc. Chinese crude drug.Its concrete Chinese crude drug has:

Colla cornus cervi: sweet, salty, temperature.Return Liver Channel, kidney channel.Temperature compensation Liver and kidney, beneficial intensive culture blood.

Rhizoma Zingiberis Preparatum: pungent, heat.Return stomach, spleen, Liver Channel.Warming spleen and stomach for dispelling cold, warming middle-JIAO stops blooding.

Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.

Cortex Cinnamomi: pungent, sweet, heat.GUIXIN, spleen, liver, kidney channel.Complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation.

Rhizoma Dioscoreae: sweet, warm, flat.Return lung, spleen, kidney channel.Strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, life lengthening.

Radix Scrophulariae: bitter, salty, cool.Return lung, kidney channel.Removing heat from blood YIN nourishing, eliminating fire and detoxication.

Cortex Moutan: bitter, pungent, is slightly cold.GUIXIN, liver, kidney channel clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.

Cortex Lycii: sweet, cold.Return lung, kidney channel.Removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.

Radix Codonopsis: sweet is flat.Return spleen, lung meridian.Spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.

The Radix Paeoniae Alba: bitter, sour, is slightly cold.Return liver, spleen channel.Nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.

Radix Bupleuri: pungent, bitter, is slightly cold.Evacuation is brought down a fever, soothing liver-QI for relieving depression, elevate a turnable ladder yang-energy.

Radix Scutellariae: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.

Rhizoma Cimicifugae: pungent, micro-sweet, is slightly cold.Return lung, spleen, stomach, large intestine channel.Deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.

Fructus Aurantii: bitter, pungent, sour, is slightly cold.Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Radix Glycyrrhizae Preparata: sweet is flat.GUIXIN, lung, spleen, stomach warp.Spleen reinforcing stomach function regulating, Yiqi and vein recovery.

Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.

Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.Enrich blood YIN nourishing, beneficial essence fills out marrow.

Rhizoma Atractylodis Macrocephalae (parched with bran): bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.

Rhizoma Alismatis: sweet, light, cold.Return kidney, urinary bladder channel promoting diuresis to eliminate damp pathogen, expel the heat-evil, change turbid blood fat reducing.

The present invention treats the drug matching combination of tumor, be instruct with Chinese medical theory, employing nourishing YIN sun, replenishing QI and blood, eliminating damp-heat, the prescription of regulating functional activities of qi function, the preparation be made up of the Chinese crude drug of following weight proportion: Fructus Aurantii 15(9-40), Rhizoma Cimicifugae 10(6-40), Radix Scutellariae 10(9-30), Radix Bupleuri 15(3-30), Radix Codonopsis 30(10-50), Rhizoma Atractylodis Macrocephalae (parched) 15(9-45), Radix Angelicae Sinensis 15(6-40), Radix Paeoniae Alba 30(9-40), Polyporus 10(9-30), Rhizoma Alismatis 15(6-30), Poria 30(9-40), Cortex Moutan 10(9-30), Radix Scrophulariae 30(10-40), Cortex Lycii 15(9-30), Fructus Corni 15(6-30), Rhizoma Dioscoreae 30(6-30), Colla cornus cervi 15(6-30), Rhizoma Zingiberis Preparatum 10(6-30), Cortex Cinnamomi 10(6-30), Radix Rehmanniae Preparata 30(9-50), Radix Glycyrrhizae 5(3-20), Radix Glycyrrhizae Preparata 5(3-20).

Dosage form of the present invention is tablet, capsule, pill, mixture, granule.

Each dosage form preparation method of the present invention: prescription mixing pressed by medical material, decoct with water secondary, 10 times of water gagings, decoct 2 hours for the first time, second time 8 times of water gagings, decoct 1 hour, merging filtrate, filter, filtrate is concentrated into relative density 1.12(60 DEG C), let cool, add ethanol and make alcohol content be 65%, leave standstill 6 hours; Get supernatant and reclaim ethanol, be concentrated into appropriate, drying and crushing or directly add suitable adjuvant and make corresponding dosage form.

Detailed description of the invention

Embodiment 1: take Fructus Aurantii 9 parts by weight ratio, Rhizoma Cimicifugae 18 parts, Radix Scutellariae 20 parts, Radix Bupleuri 9 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 9 parts, Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 10 parts, Polyporus 15 parts, Rhizoma Alismatis 24 parts, 15 parts, Poria, Cortex Moutan 20 parts, Radix Scrophulariae 15 parts, Cortex Lycii 10 parts, Fructus Corni 6 parts, Rhizoma Dioscoreae 10 parts, Colla cornus cervi 10 parts, Rhizoma Zingiberis Preparatum 18 parts), Cortex Cinnamomi 15 parts, 15 parts, Radix Rehmanniae Preparata, 9 parts, Radix Glycyrrhizae, Radix Glycyrrhizae Preparata 9 parts, decoct with water secondary, 10 times of water gagings for the first time, decoct 2 hours, second time 8 times of water gagings, decoct 1 hour, merging filtrate, filter, filtrate is concentrated into relative density 1.12(60 DEG C), let cool, adding ethanol makes alcohol content be 65%, leave standstill 6 hours, get supernatant and reclaim ethanol, be concentrated into appropriate, add starch appropriate, granulate, dry, tabletting, makes tablet.

Claims

1. one group of coordinating YIN and YANG QI and blood treats drug regimen of tumor and preparation method thereof, it is characterized in that, be made up of following Chinese crude drug compatibility: Fructus Aurantii, Rhizoma Cimicifugae, Radix Scutellariae, Radix Bupleuri, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Radix Angelicae Sinensis, the Radix Paeoniae Alba, Polyporus, Rhizoma Alismatis, Poria, Cortex Moutan, Radix Scrophulariae, Cortex Lycii, Fructus Corni, Rhizoma Dioscoreae, Colla cornus cervi, Rhizoma Zingiberis Preparatum, Cortex Cinnamomi, Radix Rehmanniae Preparata, Radix Glycyrrhizae, Radix Glycyrrhizae Preparata.

2. the drug matching combination of the treatment tumor described in patent requirements 1, is characterized in that, has eliminating damp-heat, adjusts the prescription of punching removing toxic substances, supplementing QI and nourishing YIN, the preparation be made up of the Chinese crude drug of following weight proportion:

Fructus Aurantii 9-40 part, Rhizoma Cimicifugae 6-40 part, Radix Scutellariae 9-30 part, Radix Bupleuri 3-30 part, Radix Codonopsis 10-50 part, Rhizoma Atractylodis Macrocephalae (parched) 9-45 part, Radix Angelicae Sinensis 6-40 part, Radix Paeoniae Alba 9-40 part, Polyporus 9-30 part, Rhizoma Alismatis 6-30 part, Poria 9-40 part, Cortex Moutan 9-30 part, Radix Scrophulariae 10-40 part, Cortex Lycii 9-30 part, Fructus Corni 6-30 part, Rhizoma Dioscoreae 6-30 part, Colla cornus cervi 6-30 part, Rhizoma Zingiberis Preparatum 6-30 part, Cortex Cinnamomi 16-30 part, Radix Rehmanniae Preparata 9-50 part, Radix Glycyrrhizae 3-20 part, Radix Glycyrrhizae Preparata 3-20 part.

3. the prescription described in patent requirements 2, is characterized in that: described dosage form is tablet, capsule, pill, mixture, granule.

4. the preparation method of dosage form described in patent requirements 3, is characterized in that: medical material, by prescription mixing, decocts with water secondary, 10 times of water gagings for the first time, decoct 2 hours, second time 8 times of water gagings, decoct 1 hour, merging filtrate, filter, filtrate is concentrated into relative density 1.12(60 DEG C), let cool, adding ethanol makes alcohol content be 65%, leaves standstill 6 hours; Get supernatant and reclaim ethanol, be concentrated into appropriate, drying and crushing or directly add suitable adjuvant and make corresponding dosage form.