CN103990010A

CN103990010A - Pharmaceutical composition for treating cancer and preparation method thereof

Info

Publication number: CN103990010A
Application number: CN201410091485.XA
Authority: CN
Inventors: 王长林
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-03-13
Filing date: 2014-03-13
Publication date: 2014-08-20

Abstract

The invention discloses a traditional Chinese medicine composition for treating cancer and a preparation method thereof. The prescription comprises coptis root, Caulis Clematidis armandii, rhizoma alismatis, desmodium, dittany bark, and Herba Hedyotis. The corresponding compatibility has the efficacies of clearing heat, eliminating dampness, regulating thoroughfare vessels, detoxifying, supplementing Qi and nourishing yin. Clinical application proves that the combined prescription has the advantages of simultaneous treatment of principal and subordinate symptoms, short course of treatment and quick effectiveness, and is suitable for damp-heat syndrome type of cancer at all stages.

Description

Drug regimen and the preparation method for the treatment of cancer

Technical field

The present invention relates to drug matching combination of one group for the treatment of cancer card and preparation method thereof, the Chinese medicine preparation of specifically preparing taking Chinese crude drug as raw material, belongs to Chinese materia medica field.

Background technology

World Health Organization (WHO): cancer is one group of common name that can affect the various diseases at any position of health.Other term using is cancer card and vegetation.A defined feature of cancer is to produce fast abnormal cell, and these cells surmount its common border growth and can attack adjoining position and being diffused into other organ of health.This process is referred to as transfer.Transfer is the lethal main cause of cancer.

Cancer be body in environmental pollution, chemical contamination (chemical toxicant), ionizing radiation, free radical toxin, microorganism (antibacterial, fungus, virus etc.) and metabolism toxin, inherited character, endocrine is unbalance, cause the result of health normal cell generation canceration under the effect of the various carcinogen of immunologic function disorder etc., carcinogenic factor.Often show as: the cellular abnormality hypertrophy of local organization and the local lump that forms.Cancer is that organism normal cell is in many reasons, multistage and the caused one large class disease of repeatedly suddenling change.

The feature of cancerous cell is: unrestrictedly, hypertrophy without end, the nutrient substance in patient body is consumed in a large number; Cancerous cell discharges multiple toxin, makes human body produce series of symptoms; Cancerous cell also can be transferred to whole body growth and breeding everywhere, cause that human body is become thin, unable, anemia, inappetence, heating and serious organ function impaired etc.

The etiology and pathogenesis of cancer, inventor thinks, and primary disease and vital QI being weakened and pathogen being violent are invaded human body by the damp and hot poison in the world, make yang blood and qi reverse contraryization, and visceral dysfunction causes yin-Yang from causing absolutely.

For the pathogenesis of cancer, the present invention, taking Chinese medical theory as guidance, adopts eliminating damp-heat, adjusts the methods such as punching removing toxic substances, supplementing QI and nourishing YIN, and determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, has fundamentally controlled the important paathogenic factor that cancer is demonstrate,proved, and reaches and dispels the cause of disease, recovers the gasification of human body.

Clinical proof, this combination prescription treating both the principal and secondary aspects of a disease, short treating period, instant effect, the different times of applicable all damp and hot pattern of syndrome cancers.

Summary of the invention

The present invention, in order to treat cancer card, provides the composition with Chinese crude drug compatibilities such as Rhizoma Coptidis, Caulis Clematidis Armandii, Rhizoma Alismatis, Herba Lysimachiae, favus skin, Herba Hedyotidis Diffusaes, and its concrete Chinese crude drug has:

Rhizoma Coptidis: hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.

Flos Lonicerae: sweet, cold.Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, dispelling wind and heat pathogens.

Rhizoma Smilacis Glabrae: sweet, light, flat.Return liver, stomach warp.Removing toxic substances, dehumidifying, easing joint movement.

Herba Scutellariae Barbatae: pungent, bitter, cold.Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, blood stasis dispelling diuresis.

Radix Codonopsis: sweet, flat.Return spleen, lung meridian.Spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.

Radix Adenophorae: sweet, be slightly cold.Attach to the lung and stomach meridians.Nourishing YIN and clearing away lung-heat, the raw dregs of stomach reinforcing, reduces phlegm, QI invigorating.

The Radix Paeoniae Alba: bitter, sour, be slightly cold.Return liver, spleen channel.Nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, suppressing liver-YANG.

Radix Polygoni Multiflori: bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel.Removing toxic substances, eliminating carbuncle, preventing the attack (or recurrence) of malaria, loosening bowel to relieve constipation.

Radix Polygoni Multiflori Preparata: bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel.Invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening, changes turbid blood fat reducing.

Radix Bupleuri: pungent, bitter, be slightly cold.Evacuation is brought down a fever, soothing liver-QI for relieving depression, elevate a turnable ladder yang-energy.

Radix Scutellariae: hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.

Rhizoma Cimicifugae: pungent, micro-sweet, be slightly cold.Return lung, spleen, stomach, large intestine channel.Deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.

Fructus Aurantii: bitter, pungent, sour, be slightly cold.Return spleen, stomach warp.Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Radix Glycyrrhizae Preparata: sweet, flat.GUIXIN, lung, spleen, stomach warp.Spleen reinforcing stomach function regulating, Yiqi and vein recovery.

Radix Trichosanthis: acid, sweet, bitter, cold.Return stomach, lung meridian.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.

Herba Lysimachiae: sweet, salty, be slightly cold.Return liver, gallbladder, kidney, urinary bladder channel.Eliminating damp-heat, treating stranguria, detumescence.

Favus skin: hardship, cold.Return spleen, stomach, urinary bladder channel.Heat clearing and damp drying, the removing toxic substances of dispeling the wind.

Radix Gentianae: hardship, cold.Return liver, gallbladder meridian.Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.

Rhizoma Alismatis: sweet, light, cold.Return kidney, urinary bladder channel promoting diuresis to eliminate damp pathogen, expel the heat-evil, change turbid blood fat reducing.

Caulis Clematidis Armandii: hardship, cold.GUIXIN, small intestinal, urinary bladder channel.Inducing diuresis for treating stranguria syndrome, the relieving restlessness that clears away heart-fire, the stimulating milk secretion of stimulating the menstrual flow.

Herba Hedyotidis Diffusae: micro-hardship, micro-sweet, is slightly cold.GUIXIN, liver, spleen channel.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema.

Herba Artemisiae Scopariae: bitter, pungent, be slightly cold.Return spleen, stomach, liver, gallbladder meridian.Clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cortex Moutan 3-15 part

Fructus Gardeniae: hardship, cold.GUIXIN, lung, tri-jiao channel.Pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Externally used detumescence pain relieving.

Poria: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.

Semen Coicis: sweet light, cool.Return spleen, lung, kidney channel.Spleen invigorating, tonifying the lung, heat clearing away, dampness removing.

Polyporus: sweet, light, flat.Return kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen.

Semen Plantaginis: sweet, cold.Return liver, kidney, lung, small intestine meridian.Clearing away heat and promoting diuresis is treating stranguria, eliminating dampness by diuresis antidiarrheal, and improving eyesight, eliminates the phlegm.

Rhizoma Atractylodis Macrocephalae (parched): bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.

Herba Solani Lyrati: sweet, bitter, cold.Mild toxicity.Return liver, gallbladder, kidney channel.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.

Herba Lobeliae Chinensis: pungent, light, cold.GUIXIN, small intestinal, lung meridian.Heat-clearing and toxic substances removing, inducing diuresis to remove edema.

The Radix Aucklandiae: pungent, bitter, temperature.Return lung, spleen, Liver Channel.Promoting the circulation of QI to relieve pain, intestinal stasis relieving in tune.

Cortex Magnoliae Officinalis: pungent, bitter, temperature.Return stomach, spleen, large intestine channel.Dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.

The present invention is the drug matching combination for the treatment of cancer.Effect is eliminating damp-heat, adjusts and rush removing toxic substances, supplementing QI and nourishing YIN.It is the preparation of being made by the Chinese crude drug of following weight proportion: Rhizoma Coptidis 3-10 part Caulis Clematidis Armandii 3-6 part Rhizoma Alismatis 6-30 part Herba Lysimachiae 10-60 part favus skin 6-30 part Herba Hedyotidis Diffusae 10-60 part Radix Trichosanthis 6-30 part Flos Lonicerae 10-100 part Rhizoma Smilacis Glabrae 6-30 part Herba Scutellariae Barbatae 10-60 part Radix Gentianae 3-6 part Herba Artemisiae Scopariae 10-60 part Radix Codonopsis 10-60 part Radix Adenophorae (Radix Glehniae) 6-30 part Radix Paeoniae Alba 6-60 part Radix Polygoni Multiflori 10-50 part Radix Polygoni Multiflori Preparata 10-50 part Radix Bupleuri 6-24 part Radix Scutellariae 6-30 part Rhizoma Cimicifugae 3-15 part Fructus Aurantii 5-30 part Radix Glycyrrhizae 3-15 part Radix Glycyrrhizae Preparata 3-15 part Cortex Moutan 3-15 part Fructus Gardeniae 3-30 part Poria 3-60 part Semen Coicis 3-60 part Polyporus 3-10 part Semen Plantaginis 10-30 part Rhizoma Atractylodis Macrocephalae 10-30 part Herba Solani Lyrati 3-6 part Herba Lobeliae Chinensis 6-20 part Radix Aucklandiae 3-15 part Cortex Magnoliae Officinalis 3-15 part.

Dosage form of the present invention is tablet, capsule, pill, mixture, granule.

Each dosage form preparation method of the present invention: medical material mixes by prescription, decoct with water secondary, 10 times of water gagings for the first time, decoct 2 hours, 8 times of water gagings for the second time, decoct 1 hour, merging filtrate, filters, filtrate is concentrated into relative density 1.10 (60 DEG C), let cool, adding ethanol, to make alcohol content be 65%, leaves standstill 6 hours; Get supernatant and reclaim ethanol, be concentrated into appropriate, drying and crushing or directly add suitable adjuvant to make corresponding dosage form.

Detailed description of the invention

Embodiment 1: take 20 parts of 45 portions of Radix Paeoniae Albas of 6 parts of Flos Loniceraes of 6 parts of Radix Trichosanthis of 3 parts of Herba Hedyotidis Diffusaes of 9 parts of favus skins of 6 portions of Herba Lysimachiaes of 9 portions of Rhizoma Alismatis of 3 portions of Caulis Clematidis Armandiis of Rhizoma Coptidis, 15 parts of Radix Adenophorae (Radix Glehniae) of 50 parts of Radix Codonopsis of 24 portions of Herba Artemisiae Scopariaes of 6 portions of Radix Gentianaes of 12 parts of Rhizoma Smilacis Glabraes, 9 Herba Scutellariae Barbatae by the present invention's weight proportion of writing out a prescription) 6 parts of 3 parts of Cortex Magnoliae Officinalis of 6 parts of Radix Aucklandiae of 3 portions of Herba Lobeliae Chinensis of 10 parts of Herba Solani Lyratis of 10 parts of Rhizoma Atractylodis Macrocephalaes of 3 portions of Semen Plantaginiss of 3 portions of Polyporus of 3 parts of Semen Coicis of 9 parts of Poria of 6 portions of Fructus Gardeniaes of 6 parts of Cortex Moutans of 3 parts of Radix Glycyrrhizae Preparatas of 30 portions of Radix Glycyrrhizaes of 9 parts of Fructus Aurantiis of 30 parts of Rhizoma Cimicifugaes of 15 parts of Radix Scutellariaes of 45 parts of Radix Bupleuri of 30 parts of Radix Polygoni Multiflori Preparatas of Radix Polygoni Multiflori, decoct with water secondary, 10 times of water gagings for the first time, decoct 2 hours, 8 times of water gagings for the second time, decoct 1 hour, merging filtrate, filter, filtrate is concentrated into relative density 1.10 (60 DEG C), let cool, adding ethanol, to make alcohol content be 65%, leave standstill 6 hours, get supernatant and reclaim ethanol, be concentrated in right amount, add starch appropriate, granulate, dry, tabletting, makes tablet.

Claims

1. the drug matching combination of one group for the treatment of cancer card, is characterized in that, is made up of following Chinese crude drug compatibility:

Rhizoma Coptidis, Caulis Clematidis Armandii, Rhizoma Alismatis, Herba Lysimachiae, favus skin, Herba Hedyotidis Diffusae, Radix Trichosanthis, Flos Lonicerae, Rhizoma Smilacis Glabrae, Herba Scutellariae Barbatae, Radix Gentianae, Herba Artemisiae Scopariae, Radix Codonopsis, Radix Adenophorae (Radix Glehniae), the Radix Paeoniae Alba, Radix Polygoni Multiflori, Radix Bupleuri, Radix Scutellariae, Rhizoma Cimicifugae, Fructus Aurantii, Radix Glycyrrhizae, Radix Glycyrrhizae Preparata etc.

2. patent requires the drug matching combination of the treatment tumor described in 1, it is characterized in that, has eliminating damp-heat, adjusts the prescription that rushes removing toxic substances, supplementing QI and nourishing YIN, the preparation of being made up of the Chinese crude drug of following weight proportion:

The sweet 3-15 of Rhizoma Coptidis 3-10 Caulis Clematidis Armandii 3-6 Rhizoma Alismatis 6-30 Herba Lysimachiae 10-60 favus skin 6-30 Herba Hedyotidis Diffusae 10-60 Radix Trichosanthis 6-30 Flos Lonicerae 10-100 Rhizoma Smilacis Glabrae 6-30 Herba Scutellariae Barbatae 10-60 Radix Gentianae 3-6 Herba Artemisiae Scopariae 10-60 Radix Codonopsis 10-60 Radix Adenophorae (Radix Glehniae) 6-30 Radix Paeoniae Alba 6-60 Radix Polygoni Multiflori 10-50 Radix Polygoni Multiflori Preparata 10-50 Radix Bupleuri 6-24 Radix Scutellariae 6-30 Rhizoma Cimicifugae 3-15 Fructus Aurantii 5-30

Radix Glycyrrhizae Preparata 3-15 Cortex Moutan 3-15 Fructus Gardeniae 3-30 Poria 3-60 Semen Coicis 3-60 Polyporus 3-10 Semen Plantaginis 10-30 Rhizoma Atractylodis Macrocephalae 10-30 Herba Solani Lyrati 3-6 Herba Lobeliae Chinensis 6-20 Radix Aucklandiae 3-15 Cortex Magnoliae Officinalis 3-15.

3. patent requires the prescription described in 2, it is characterized in that: described dosage form is tablet, capsule, pill, mixture, granule.

4. patent requires the preparation method of dosage form described in 3, it is characterized in that: medical material mixes by prescription, decocts with water secondary, 10 times of water gagings for the first time, decoct 2 hours, 8 times of water gagings for the second time, decoct 1 hour, merging filtrate, filter, filtrate is concentrated into relative density 1.10 (60 DEG C), lets cool, adding ethanol, to make alcohol content be 65%, leaves standstill 6 hours; Get supernatant and reclaim ethanol, be concentrated into appropriate, drying and crushing or directly add suitable adjuvant to make corresponding dosage form.